Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from...
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Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from other centres – Generate bone marrow chimeras Or generate
Immune System Objectives To select genes that are embryonic
lethal Or accept bone marrow from other centres Generate bone
marrow chimeras Or generate conditional mutants for EUCOMM allels
Analyse phenotypes of these mutants and Establish the course of
embryonic lethality
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Members of the Network Principal Investigator Werner Muller,
University of Manchester, Faculty of Life Science, AV Hill
Building, M13 9PT Manchester; Email: [email protected]
Co-Investigators Immunology: Richard Grencis, Kathryn Else, Mark
Travis, Sheena Cruikshank, Douglas Millar, Dr. Mat Hardman, Paul
Lyons, Jim Middleton Immune Toxicology: Ian Kimber Neurobiology:
Emmanuel Pinteaux, Stuart Allan Cardiology: Ludwig Neyses,
Elizabeth Cartwright, Delvac Oceandy Developmental Biology: Mike
Dixon, Kathryn Hentges Human Genetics: Yanick Crow Bioinformatics:
Andy Brass, Robert Stevens Manchester Centre for Nuclear Hormone
Research in Disease: David Ray
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Example 1 Analysis of a B cell phenotype for an embryonic
lethal mutation (polymerase beta)
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Example2 Analysis of a complex phenotype for an embryonic
lethal mutation using conditional gene targeting (gp130)
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neurological, cardiac, hematopoietic, immunological, hepatic
and pulmonary
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Immune System Objectives To select genes that are embryonic
lethal Or accept bone marrow from other centres Generate bone
marrow chimeras Or generate conditional mutants for EUCOMM allels
Analyse phenotypes of these mutants and Establish the course of
embryonic lethality