IMARS HIGHLIGHTS · Otto Heinrich Warburg, Nobel prize winner (1931) a German physiologist, found that cancer tissues consume large amounts of glucose compared to normal tissue and

© 2013 International Maillard Reaction Society 1

IMARS

HIGHLIGHTS

Research Commentaries for the Members of

The International Maillard Reaction Society

A Non-profit Research and Education Organization in Biomedicine and Food Science

Volume 13

Number 2

March 22, 2018

IMARS Highlights www.imars.org Volume 13, Number 2

March 22, 2018

© 2013 International Maillard Reaction Society 2

IMARS HIGHLIGHTS

Research Commentaries for the Members of

The International Maillard Reaction Society

A Non-profit Research and Education Organization in Biomedicine and Food Science

Volume 13

Number 2

March 22, 2018

Editor Reiko Inagi (JP) Contributing Editors Josephine M. Forbes (AUS) Vincenzo Fogliano (IT) Alejandro Gugliucci (USA) Toshio Miyata (JP) Monika Pischetsrieder (DE) Alan Stitt (NI) Varoujan Yaylayan (CA) Rosario Zamora (ES) Ryoji Nagai (JP) Fred Tessier (FR) Norma Frizzell (USA) Kiyotaka Nakagawa (JP) Yukio Fujiwara (JP) IMARS Established in 2005, the International Maillard Reaction Society gathers researchers and clinicians involved in the field of carbonyl reactions in foods, biology and medicine. It promotes research on Maillard Reaction and protein glycation and their numerous applications. It also organizes regular international congresses on the same theme, in addition to those that have been taken place since 1979. www.imars.org


March 22, 2018

IMARS HIGHLIGHTS

Volume 13, Number 2, March 22, 2018

CONTENTS OF THIS ISSUE: - Editorial comment

Reiko Inagi - Potential usability of Amadori-glycated phosphatidylethanolamine as a

glycoconjugated biomaterial Taiki Miyazawa, Reina Kamiyoshihara, Teruo Miyazawa and Kiyotaka Nakagawa

- Highlights of the glycation literature (January 2018-March 2018)

16 11

5

4


March 22, 2018

4

Editorial comments

In this issue, Prof. Kiyotaka Nakagawa and his colleagues at Graduate School of Agricultural Science, Tohoku University, Sendai, Japan, kindly published the mini review, entitled “Potential usability of Amadori-glycated phosphatidylethanolamine as a glycoconjugated biomaterial”. This article highlights the potential use of Amadori-glycated phosphatidylethanolamine (Amadori-PE) as a glycoconjugated biomaterial for targeting glucose transporter-mediated transport. Of note, the liposomes containing Amadori-PE are predominantly taken up by the cells, which highly express glucose transporters. They demonstrated that Amadori-PE may be significantly beneficial as biomaterials.

In this year, the 13th International Symposium on the Maillard reaction (ISMR) will be held in Montreal, Canada (September 10-13). On behalf of the IMARS president Prof. Varoujan A. Yaylayan, I would like to invite all of the IMARS members to submit your abstracts.

IMARS committees are very much looking forward to seeing you and to deepening our fruitful scientific discussion in Montreal!

Reiko Inagi,Ph.D. Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine email: [email protected]


March 22, 2018

5

Potential usability of Amadori-glycated phosphatidylethanolamine as a glycoconjugated biomaterial

(short review) Taiki Miyazawa1, Reina Kamiyoshihara2, Teruo Miyazawa3,4, Kiyotaka Nakagawa2*

1Institute of Biomaterials & Bioengineering, Tokyo Medical and Dental University,

Tokyo 101-0062, Japan 2Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural

Science, Tohoku University, Sendai 980-0845, Japan 3Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center

(NICHe), Tohoku University, Sendai 980-8579, Japan 4Food and Health Science Research Unit, Graduate School of Agricultural Science,

Tohoku University, Sendai 980-0845, Japan

*Corresponding author. Tel: +81-22-757-4416 Fax: +81-22-757-4417.

E-mail address: [email protected] (K. Nakagawa).

1. Introduction

A large number of biomaterials (e.g. liposomes, micelles and nanoparticles)

have been used for treatment in various diseases such as cancer [1, 2], because these

biomaterials have held a several beneficial abilities by modifying their formulation

and surfaces. On the other hand, Amadori-glycated phosphatidylethanolamine

(Amadori-PE, Figure 1B, D) is a Maillard reaction product that contains a saccharide

moiety in its chemical structure [3-9]. Because of its chemical structure, it has a

potential for use as biomaterials. In this short review, we focused on the potential use

of Amadori-PE as a glycoconjugated biomaterial for targeting glucose transporter

(GLUT)-mediated transport.

2. Prevalence of GLUT on cancer cells

Otto Heinrich Warburg, Nobel prize winner (1931) a German physiologist,

found that cancer tissues consume large amounts of glucose compared to normal

tissue and high amounts of aerobic glycolysis [10]. This phenomenon is called

“Warburg effect” and it is well recognized as characteristic of cancer [11]. Based on

this phenomenon, GLUT is widely overexpressed on cancer cells.

3. Glycoconjugated drug for cancer treatment

Cellular transporters are well known as important determinants governing

drug uptake into target organs. Among them, glycoconjugation-mediated cancer

treatment via GLUT is one of the investigated approaches. A glucose analog, 2-deoxy-

2-(18F) fluoro-D-glucose (18F-FDG, Figure 1E) is used to visualize tumors by positron


March 22, 2018

6

emission tomography (PET) [12]. In addition, clinical approaches for glycoconjugated

anticancer drugs are on the way. 1-β-D-glucose conjugated ifosfamide mustard,

Glufosfamide (Figure 1F), is already in human clinical trials. For example, 13

Japanese patients with various solid tumors (colorectal cancer, non-small cell lung

cancer, thymic cancer, thymoma, gallbladder cancer, gastric cancer and uterine

corpus-endometrial cancer) who relapsed after standard chemotherapy or no effective

standard therapy were subjected to human clinical trial of Glufosfamide [13]. As a

result, 8 patients showed disease stabilization, 4 patients showed progressive disease

and one patient showed partial response. However, our knowledge concerning the

clinical dynamics of glycoconjugated anticancer drug is still scarce. More

investigation for clarifying the effectiveness of these glycoconjugated drugs would be

of vital importance.

Figure 1. Chemical structures of related compounds in this review.

4. Amadori-glycated PE as a liposome carrier for cancer treatment

In this section, we introduce our recent research related to Amadori-PE [14].

As mentioned in the introduction, liposomes are well known biomaterial for

controlling the retention of encapsulated drugs in circulation, sustained release,

dispersibility, delivery to specific tissues and so on by modifying its chemical

structure of the lipid formulation and associated surfaces [2]. Generally, liposomes are

prepared from phosphatidylcholine (PC, Figure 1A). However, liposomes comprised

of 100% PC exhibit poor membrane fusion, cellular uptake, and selective targeting

capacities [15, 16]. To overcome these limitations, we focused on preparing liposomes

HN

OH

CH2OH

OH

OHO

HN

OH

CH2OH

OH

O

OO

OH

OHOH

CH2OH

OP

O

O

O

OR1

O

O

R2

OH

OP

O

O

O

OR1

O

O

R2

OH

H2NO

P

O

O

O

OR1

O

O

R2

OH

N+

OP

O

O

O

OR1

O

O

R2

OH

OHO

18F

OHOH

CH2OH

P

O HN

NH Cl

Cl

OO

OH

OHOH

CH2OH

Phosphatidylcholine(PC)

Phosphatidylethanolamine(PE)

Amadori-glycated phosphatidylethanolamine(reacted with glucose, GPE)

Amadori-glycated phosphatidylethanolamine(reacted with lactose, LPE)

2-Deoxy-2-(18F) fluoro-D-glucose(18F-FDG)

Glufosfamide

A B

C D

E F

R = R = Palmitic acid

1 2


March 22, 2018

7

from mixtures of PC and 2 kinds of Amadori-PE (glucose-PE (GPE) and lactose-PE

(LPE), Figure 1B, D). We hypothesized that liposomes prepared from mixtures of PC

and Amadori-PE should exhibit enhanced membrane fusion and cellular uptake

capacities due to the presence of the phosphatidylethanolamine (PE, Figure1C) sites

[15], while the presence of the saccharide moiety would allow for targeting of cells

that highly express GLUTs on their membranes [17]. Thus, we examined the uptake

of GPE and LPE containing liposomes into cells, to evaluate their potential for use in

biomaterials. To confirm the cellular uptake capacity of liposomes, we used human

intestinal epithelial (Caco-2) cells as a model cancer cells and lipophilic polyphenol

curcumin (CUR) as a model drug [18, 19].

Figure 2. A: Average particle size of liposomes prepared from different ratios of PC and glycated PE (glucose-PE (GPE) and lactose-PE (LPE)). Mean±SD, n=3. Means

significantly differed at **P < 0.01. B: Cellular uptake of Curcumin (CUR)-encapsulated liposomes. Liposomes were prepared from phosphatidylcholine (PC)

and Amadori-glycated phosphatidylethanolamine (Amadori-PE) (glucose-PE (GPE), lactose-PE (LPE)) or non-glycated PE. The ratio of PC to Amadori-PE (or non-

glycated PE) was adjusted to 3:1 in all groups. Statistical significance between groups was assessed by Dunnett’s test. Data are mean±SD, n=3. (Modified from Miyazawa et

al., [14]).

As a result, we optimized the preparation of Amadori-PE (or non-glycated PE)

containing liposomes with around 100 nm mean diameters (Figure 2A) [14]. In

addition, cellular uptake study demonstrated that liposomes containing Amadori-PE

(GPE and LPE) tended to increase the uptake of CUR into Caco-2 cells compared

with liposomes containing non-glycated PE (Figure 2B) [14]. It can be inferred that

liposomes containing Amadori-PE are taken up by Caco-2 cells due to the presence of

the saccharide moiety, which binds to GLUTs [20]. On the other hand, levels of

cellular uptake of liposomes containing GPE tended to be higher than those of

liposomes containing LPE (GPE: P =0.08, LPE: P =0.27, Figure 2B). GLUTs are

known to recognize the structure of monosaccharides at the time of sugar uptake into

PC:PE(3:1)

PC:GPE(3:1)

PC:LPE(3:1)

0

5

10

15

20

25

Am

ount

of

CU

R (

pm

ol/

10

cel

l)

P = 0.08

P = 0.27

10 100 1000 10000

Particle size (nm)

Rel

ativ

e in

ten

sity

(%

)

1

100

0

PC:PE=3:1123±4 nm

PC:GPE=3:1107±3** nm

PC:LPE=3:1120±4 nm

A B

cells [17]. Additionally, site o

recognized by GLUT 5 of certain tumors (including Cac

system [20-22]. Therefore, it is speculated that Amadori

monosaccharide is more easily recognized by

increased cellular uptake compared with LPE, which contains the

(Figure 3). This phenomenon can be utilized to enhance the selective targeting and

subsequent cellular uptake of liposomes.

Figure 3. Assumed behav

5. Conclusion

It is considered that liposomes containing Amadori

cells that highly express GLUTs. These characteristics should allow fo

potential applications, such as increased uptake of encapsulated drugs to target cells

following intravenous injection, and enhancement of absorption of encapsulated

nutrients in the intestine. Taken together, the results of this study suggest that

Amadori-PE may have an imminent potential for use as biomaterials in the future.

6. References

1) Moghimi SM, Hunter AC, Murray JC, Nanomedicine: current status and future

prospects. FASEB J. 19, 311

2) Allen TM, Cullis PR, Liposomal drug delivery systems: from concept t

applications. Adv Drug Deliv Rev

3) Oak JH, Nakagawa K, Miyazawa T, UV analysis of Amadori

phosphatidylethanolamine in foods and biological samples.

529 (2002).

4) Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H,

Miyazawa T, Ion-trap tandem mass spectrometric analysis of Amadori

phosphatidylethanolamine in human plasma with or without diabetes.

46, 2514-2524 (2005).

5) Miyazawa T, Oak JH, Nakagawa K, A convenient method for preparation of high

IMARS www.imars.org Volume 13, Number 2

March 2

8

[17]. Additionally, site of fructosyl moiety of Amadori-PE might be specifically

recognized by GLUT 5 of certain tumors (including Caco-2 cells) and digestive

22]. Therefore, it is speculated that Amadori-PE, which contains the

monosaccharide is more easily recognized by GLUT 5, which resulted in the

increased cellular uptake compared with LPE, which contains the disaccharide

his phenomenon can be utilized to enhance the selective targeting and

subsequent cellular uptake of liposomes.

behavior of liposomes used in the study. (Modified from Miyazawa et al., [14])

It is considered that liposomes containing Amadori-PE are taken up by the

cells that highly express GLUTs. These characteristics should allow fo

ications, such as increased uptake of encapsulated drugs to target cells



n imminent potential for use as biomaterials in the future.

Moghimi SM, Hunter AC, Murray JC, Nanomedicine: current status and future

, 311-330 (2005).

Allen TM, Cullis PR, Liposomal drug delivery systems: from concept t

Adv Drug Deliv Rev. 65, 36-48 (2013).

Oak JH, Nakagawa K, Miyazawa T, UV analysis of Amadori

phosphatidylethanolamine in foods and biological samples. J Lipid Res.

Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H,

trap tandem mass spectrometric analysis of Amadori

phosphatidylethanolamine in human plasma with or without diabetes. J Lipid Res

yazawa T, Oak JH, Nakagawa K, A convenient method for preparation of high

IMARS Highlights , Number 2

March 22, 2018

PE might be specifically

2 cells) and digestive

PE, which contains the

GLUT 5, which resulted in the

disaccharide

his phenomenon can be utilized to enhance the selective targeting and

(Modified from

E are taken up by the

cells that highly express GLUTs. These characteristics should allow for various

ications, such as increased uptake of encapsulated drugs to target cells



n imminent potential for use as biomaterials in the future.

Moghimi SM, Hunter AC, Murray JC, Nanomedicine: current status and future

Allen TM, Cullis PR, Liposomal drug delivery systems: from concept to clinical

Oak JH, Nakagawa K, Miyazawa T, UV analysis of Amadori-glycated

. 43, 523-

Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H,

trap tandem mass spectrometric analysis of Amadori-glycated

J Lipid Res.

yazawa T, Oak JH, Nakagawa K, A convenient method for preparation of high-


March 22, 2018

9

purity, amadori-glycated phosphatidylethanolamine and its prooxidant effect. Ann

N Y Acad Sci. 1043, 276-279 (2005).

6) Shoji N, Nakagawa K, Asai A, Fujita I, Hashiura A, Nakajima Y, Oikawa S,

Miyazawa T, LC-MS/MS analysis of carboxymethylated and carboxyethylated

phosphatidylethanolamines in human erythrocytes and blood plasma. J Lipid Res.

51, 2445-2453 (2010)

7) Sookwong P, Nakagawa K, Fujita I, Shoji N, Miyazawa T, Amadori-glycated

phosphatidylethanolamine, a potential marker for hyperglycemia, in

streptozotocin-induced diabetic rats. Lipids. 46, 943-952 (2011)

8) Miyazawa T, Nakagawa K, Shimasaki S, Nagai R, Lipid glycation and protein

glycation in diabetes and atherosclerosis. Amino Acids. 42, 1163-1170 (2012)

9) Suzuki K, Nakagawa K, Miyazawa T, Augmentation of blood lipid glycation and

lipid oxidation in diabetic patients. Clin Chem Lab Med. 2, 1-6 (2013)

10) Koppeno WH, Bounds PL, Dang CV, Otto Warburg's contributions to current

concepts of cancer metabolism. Nat Rev Cancer. 11, 325-327 (2011).

11) Otto AM, Warburg effect(s) - a biographical sketch of Otto Warburg and his

impacts on tumor metabolism. Cancer Metab. 4, 5 (2016).

12) Avril N, GLUT1 expression in tissue and (18)F-FDG uptake. J Nucl Med. 45,

930-932 (2004).

13) Shimizu T, Okamoto I, Tamura K, Satoh T, Miyazaki M, Akashi Y, Ozaki T,

Fukuoka M, Nakagawa K, Phase I clinical and pharmacokinetic study of the

glucose-conjugated cytotoxic agent D-19575 (glufosfamide) in patients with solid

tumors. Cancer Chemother Pharmacol. 65, 243-250 (2010).

14) Miyazawa T, Kamiyoshihara R, Shimizu N, Harigae T, Otoki Y, Ito J, Kato S,

Miyazawa T, Nakagawa K, Amadori-glycated phosphatidylethanolamine enhances

the physical stability and selective targeting ability of liposomes. R Soc Open Sci.

5, 171249 (2018).

15) Hwang TL, Lee WR, Hua SC, Fang JY, Cisplatin encapsulated in

phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in

vivo intratumor drug accumulation against melanomas. J Dermatol Sci. 46, 11-20

(2007).

16) Farhood H, Serbina N, Huang L, The role of dioleoyl phosphatidylethanolamine

in cationic liposome mediated gene transfer. Biochim Biophys Acta. 1235, 289-

295 (1995).

17) Calvaresi EC, Hergenrother PJ, Glucose conjugation for the specific targeting and

treatment of cancer. Chem Sci. 4, 2319-2333 (2013).

18) Nakagawa K, Zingg JM, Kim SH, Thomas MJ, Dolnikowski GG, Azzi A,

Miyazawa T, Meydani M, Differential cellular uptake and metabolism of

curcuminoids in monocytes/macrophages: regulatory effects on lipid

accumulation. Br J Nutr. 112, 8-14 (2014).

19) Li L, Braiteh FS, Kurzrock R, Liposome-encapsulated curcumin: in vitro and in


March 22, 2018

10

vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 104,

1322-1331 (2005).

20) Mahraoui L, Rousset M, Dussaulx E, Darmoul D, Zweibaum A, Brot-Laroche E,

Expression and localization of GLUT-5 in Caco-2 cells, human small intestine,

and colon. Am J Physiol. 263, 312-318 (1992).

21) Douard V, Ferraris RP, Regulation of the fructose transporter GLUT5 in health

and disease. Am J Physiol Endocrinol Metab. 295, E227-E237 (2008).

22) Zamora-León SP, Golde DW, Concha II, Rivas CI, Delgado-López F, Baselga J,

Nualart F, Vera JC, Expression of the fructose transporter GLUT5 in human breast

cancer. Proc Natl Acad Sci U S A. 93, 1847-1852 (1996).


March 22, 2018

11

Highlights of the glycation literature (January 2018 - March2018) Papers of Editors’ Choice Rabbani N, Thornalley PJ. Advanced glycation end products in the pathogenesis of

chronic kidney disease. Kidney Int. 2018 Feb 22. [Epub ahead of print] Antoniotti GS, Coughlan M, Salamonsen LA, Evans J. Obesity associated advanced

glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation competence. Hum Reprod. 2018 Feb 20. [Epub ahead of print]

Tong QH, Yan TY, Tao T, Zhang L, Xie LQ, Lu H. Reductive Amination Combining Dimethylation for Quantitative Analysis of Early Stage Glycated Proteins. Anal Chem. 2018 Feb 21. [Epub ahead of print]

Hagiwara S, Sourris K, Ziemann M, Tieqiao W, Mohan M, McClelland AD, Brennan E, Forbes J, Coughlan M, Harcourt B, Penfold S, Wang B, Higgins G, Pickering R, El-Osta A, Thomas MC, Cooper ME, Kantharidis P. RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis. Diabetes. 2018 Feb 15. [Epub ahead of print]

Taguchi K, Yamagishi SI, Yokoro M, Ito S, Kodama G, Kaida Y, Nakayama Y, Ando R, Yamada-Obara N, Asanuma K, Matsui T, Higashimoto Y, Brooks CR, Ueda S, Okuda S, Fukami K. RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice. Sci Rep. 2018 Feb 8;8(1):2686.

Rojas A, Añazco C, González I, Paulina A. Extracellular matrix glycation and RAGE activation. A missing piece in the puzzle of the association between diabetes and cancer. Carcinogenesis. 2018 Jan 24. [Epub ahead of print]

Chen Y, Filipov NM, Guo TL. Dietary Glycation Products Regulate Immune Homeostasis: Early Glycation Products Promote Prostate Cancer Cell Proliferation through Modulating Macrophages. Mol Nutr Food Res. 2018 Feb;62(3).

Niihata K, Takahashi S, Kurita N, Yajima N, Omae K, Fukuma S, Okano T, Nomoto Y, Omori K, Fukuhara S; Sukagawa Study Group. Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study. J Am Med Dir Assoc. 2018 Mar;19(3):235-239.

Cardoso HB, Wierenga PA, Gruppen H, Schols HA. Maillard induced glycation behaviour of individual milk proteins. Food Chem. 2018 Jun 30;252:311-317.

Baldensperger T, Jost T, Zipprich A, Glomb MA. Novel α-Oxoamide Advanced-Glycation Endproducts within the N(6)-Carboxymethyl Lysine and N(6)-Carboxyethyl Lysine Reaction Cascades. J Agric Food Chem. 2018 Feb 13. [Epub ahead of print]

Sowndhar Rajan B, Manivasagam S, Dhanusu S, Chandrasekar N, Krishna K, Kalaiarasu LP, Babu AA, Vellaichamy E. Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid. Food Chem Toxicol. 2018 Feb 10;114:237-245.

1. Ahmed A, Shamsi A, Khan MS, Husain FM, Bano B. Methylglyoxal induced

glycation and aggregation of human serum albumin: Biochemical and biophysical approach. Int J Biol Macromol. 2018 Feb 23. [Epub ahead of print]

2. Cheng K, Yang A, Hu X, Zhu D, Liu K. Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat


March 22, 2018

12

Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway. Med Sci Monit. 2018 Feb 26;24:1178-1184.

3. König A, Vicente Miranda H, Outeiro TF. Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease. J Parkinsons Dis. 2018;8(1):33-43.

4. Liu C, Chen K, Lu Y, Fang Z, Yu G. Catalpol provides a protective effect on fibrillary Aβ(1-42) -induced barrier disruption in an in vitro model of the blood-brain barrier. Phytother Res. 2018 Feb 26. [Epub ahead of print].

5. Anwar A, Abruzzo PM, Pasha S, Rajpoot K, Bolotta A, Ghezzo A, Marini M, Posar A, Visconti P, Thornalley PJ, Rabbani N. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis. Mol Autism. 2018 Feb 19;9:3. eCollection 2018.

6. Cournot M, Burillo E, Saulnier PJ, Planesse C, Gand E, Rehman M, Ragot S, Rondeau P, Catan A, Gonthier MP, Feigerlova E, Meilhac O, Hadjadj S. Circulating Concentrations of Redox Biomarkers Do Not Improve the Prediction of Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus. J Am Heart Assoc. 2018 Feb 25;7(5).

7. Liu GX, Tu ZC, Yang W, Wang H, Zhang L, Ma D, Huang T, Liu J, Li X. Investigation into allergenicity reduction and glycation sites of glycated β-lactoglobulin with ultrasound pretreatment by high-resolution mass spectrometry. Food Chem. 2018 Jun 30;252:99-107.

8. Preetha Rani MR, Anupama N, Sreelekshmi M, Raghu KG. Chlorogenic acid attenuates glucotoxicity in H9c2 cells via inhibition of glycation and PKC α upregulation and safeguarding innate antioxidant status. Biomed Pharmacother. 2018 Feb 22;100:467-477.

9. Jiang X, Wang X, Tuo M, Ma J, Xie A. RAGE and its emerging role in the pathogenesis of Parkinson's disease. Neurosci Lett. 2018 Feb 22. [Epub ahead of print]

10. Matsuura W, Harada S, Liu K, Nishibori M, Tokuyama S. Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice. Brain Res. 2018 Feb 21. [Epub ahead of print]

11. Prasanna G, Jing P. Cyanidin-3-O-glucoside functions like chemical chaperone and attenuates the glycation mediated amyloid formation in albumin. Arch Biochem Biophys. 2018 Feb 20. [Epub ahead of print]

12. Lam D, Momeni Z, Theaker M, Jagadeeshan S, Yamamoto Y, Ianowski JP, Campanucci VA. RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose. PLoS One. 2018 Feb 23;13(2):e0193312. doi: 10.1371/journal.pone.0193312. eCollection 2018. PubMed PMID: 29474476.

13. Thompson K, Chen J, Luo Q, Xiao Y, Cummins TR, Bhatwadekar AD. Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. PLoS One. 2018 Feb 23;13(2):e0193280. eCollection 2018.

14. Sun P, Cheng KW, He Y, Liu B, Mao X, Chen F. Screening and identification of inhibitors of advanced glycation endproduct formation from microalgal extracts. Food Funct. 2018 Feb 23. [Epub ahead of print]

15. Kim JH, Kim KA, Shin YJ, Kim H, Majid A, Bae ON. Methylglyoxal induced advanced glycation end products (AGE)/receptor for AGE (RAGE)-mediated angiogenic impairment in bone marrow-derived endothelial progenitor cells. J Toxicol Environ Health A. 2018 Feb 23:1-12.

16. Krajewska-Włodarczyk M, Owczarczyk-Saczonek A, Placek W, Osowski A, Wojtkiewicz J. Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy. Int J Mol Sci. 2018 Feb 22;19(2). pii:


March 22, 2018

13

17. Polverino F, Celli BR, Owen CA. COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar;8(1):2045894018758528.

18. Milione S, Di Caterino M, Monaco L, Rinaldi L. Mediation of inflammation, obesity and fatty liver disease by advanced glycation endoproducts. Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):578-579.

19. Schulz BL, Phung TK, Bruschi M, Janusz A, Stewart J, Mehan J, Healy P, Nouwens AS, Fox GP, Vickers CE. Process proteomics of beer reveals a dynamic proteome with extensive modifications. J Proteome Res. 2018 Feb 19. [Epub ahead of print]

20. Xu X, Chen Z, Zhu X, Wang D, Liang J, Zhao C, Feng X, Wang J, Zou H, Sun L. S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κB pathways. Iran J Basic Med Sci. 2018 Feb;21(2):194-201.

21. Spanos C, Maldonado EM, Fisher CP, Leenutaphong P, Oviedo-Orta E, Windridge D, Salguero FJ, Bermúdez-Fajardo A, Weeks ME, Evans C, Corfe BM, Rabbani N, Thornalley PJ, Miller MH, Wang H, Dillon JF, Quaglia A, Dhawan A, Fitzpatrick E, Bernadette Moore J. Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease. Proteome Sci. 2018 Feb 14;16:4. eCollection 2018.

22. Forbes JM, Thorburn DR. Mitochondrial dysfunction in diabetic kidney disease. Nat Rev Nephrol. 2018 Feb 19. [Epub ahead of print] Review.

23. Wang ZJ, Zhang HB, Chen C, Huang H, Liang JX. Effect of PPARG on AGEs-induced AKT/MTOR signaling-associated human chondrocytes autophagy. Cell Biol Int. 2018 Feb 17. [Epub ahead of print]

24. Oikonomou E, Mourouzis K, Fountoulakis P, Papamikroulis GA, Siasos G, Antonopoulos A, Vogiatzi G, Tsalamadris S, Vavuranakis M, Tousoulis D. Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance. Heart Fail Rev. 2018 Feb 17. [Epub ahead of print]

25. Garaschuk O, Semchyshyn HM, Lushchak VI. Healthy brain aging: Interplay between reactive species, inflammation and energy supply. Ageing Res Rev. 2018 Feb 13;43:26-45.

26. Elkomy NMIM, Ibrahim IAAE, Elshazly SM, El-Fayoumi HM. Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline-1 receptor. Eur J Pharmacol. 2018 Feb 13;824:148-156.

27. Ibuki A, Kuriyama S, Toyosaki Y, Aiba M, Hidaka M, Horie Y, Fujimoto C, Isami F, Shibata E, Terauchi Y, Akase T. Aging-like physiological changes in the skin of Japanese obese diabetic patients. SAGE Open Med. 2018 Feb 6;6:2050312118756662. eCollection 2018.

28. Hou S, Tian T, Qi D, Sun K, Yuan Q, Wang Z, Qin Z, Wu Z, Chen Z, Zhang J. S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition. Cell Death Dis. 2018 Feb 15;9(3):277.

29. Jia G, Hill MA, Sowers JR. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018 Feb 16;122(4):624-638.

30. Downs CA, Johnson NM, Tsaprailis G, Helms MN. RAGE-induced changes in the proteome of alveolar epithelial cells. J Proteomics. 2018 Feb 12;177:11-20.

31. Svensson RB, Smith ST, Moyer PJ, Magnusson SP. Effects of maturation and advanced glycation on tensile mechanics of collagen fibrils from rat tail and Achilles tendons. Acta Biomater. 2018 Feb 13. [Epub ahead of print]

32. Rodríguez-Mortera R, Luevano-Contreras C, Solorio-Meza S, Caccavello R, Bains Y, Garay-Sevilla ME, Gugliucci A. Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents. Clin Chem Lab Med. 2018 Feb 15. [Epub ahead of print]


March 22, 2018

14

33. Duburcq T, Durand A, Tournoys A, Gnemmi V, Gmyr V, Pattou F, Jourdain M, Tamion F, Besnier E, Préau S, Parmentier-Decrucq E, Mathieu D, Poissy J, Favory R. Sodium lactate improves renal microvascular thrombosis compared to sodium bicarbonate and 0.9% NaCl in a porcine model of endotoxic shock: an experimental randomized open label controlled study. Ann Intensive Care. 2018 Feb 14;8(1):24.

34. Li J, Wu PW, Zhou Y, Dai B, Zhang PF, Zhang YH, Liu Y, Shi XL. Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy. Cell Death Dis. 2018 Feb 14;9(2):225.

35. Shahriyary L, Riazi G, Lornejad MR, Ghezlou M, Bigdeli B, Delavari B, Mamashli F, Abbasi S, Davoodi J, Saboury AA. Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study. Arch Biochem Biophys. 2018 Feb 11. [Epub ahead of print]

36. Wang JS, Hung YJ, Lu YC, Tsai CL, Yang WS, Lee TI, Hsiao YC, Sheu WH. Difference between observed and predicted glycated hemoglobin at baseline and treatment response to vildagliptin-based dual oral therapy in patients with type 2 diabetes. Diabetes Res Clin Pract. 2018 Feb 11;138:119-127.

37. Khan MI, Su YK, Zou J, Yang LW, Chou RH, Yu C. S100B as an antagonist to block the interaction between S100A1 and the RAGE V domain. PLoS One. 2018 Feb 14;13(2):e0190545.

38. Jende JME, Groener JB, Oikonomou D, Heiland S, Kopf S, Pham M, Nawroth P, Bendszus M, Kurz FT. Diabetic neuropathy differs between type 1 and type 2 diabetes Insights from magnetic resonance neurography. Ann Neurol. 2018 Feb 14. [Epub ahead of print]

39. Tabassum A, Mahboob T. Role of peroxisome proliferator-activated receptor-gamma activation on visfatin, advanced glycation end products, and renal oxidative stress in obesity-induced type 2 diabetes mellitus. Hum Exp Toxicol. 2018 Jan 1:960327118757588. [Epub ahead of print]

40. Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A; ECLIPSE Study Investigators. Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype. Eur Respir J. 2018 Feb 7;51(2).

41. Mo J, Jin R, Yan Q, Sokolowska I, Lewis MJ, Hu P. Quantitative analysis of glycation and its impact on antigen binding. MAbs. 2018 Feb 13:0. [Epub ahead of print]

42. Tan JY, Zhao F, Deng SX, Zhu HC, Gong Y, Wang W. Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling. Mol Med Rep. 2018 Feb 13. [Epub ahead of print]

43. Niu G, Guo J, Tian Y, Zhao K, Li J, Xiao Q. α‑lipoic acid can greatly alleviate the

toxic effect of AGES on SH‑SY5Y cells. Int J Mol Med. 2018 Feb 8. [Epub ahead of print]

44. Li J, Yan Y, Li D, Li X, Lin X, Liu Z, Xu T, Du F. Nephroprotective effects of diacylglycerol on diabetic nephropathy in type 2 diabetic rats. Exp Ther Med. 2018 Feb;15(2):1918-1926.

45. Parveen A, Jin M, Kim SY. Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy. Phytomedicine. 2018 Jan 15;39:146-159.

46. Mukamal KJ, Siscovick DS, de Boer IH, Ix JH, Kizer JR, Djoussé L, Fitzpatrick AL, Tracy RP, Boyko EJ, Kahn SE, Arnold AM. Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study. J Am Geriatr Soc. 2018 Feb;66(2):289-296.

47. Maietta M, Colombo R, Corana F, Papetti A. Cretan tea (Origanum dictamnus L.) as a functional beverage: an investigation on antiglycative and carbonyl trapping activities. Food Funct. 2018 Feb 12. [Epub ahead of print]


March 22, 2018

15

48. Duda-Sobczak A, Zozulinska-Ziolkiewicz D, Wyganowska-Swiatkowska M. Type 1 Diabetes and Periodontal Health. Clin Ther. 2018 Feb 8. pii: S0149-2918(18)30013-4. [Epub ahead of print]

49. Bihani O, Rai T, Panda D. Interaction of proteins with lemon-juice/glutathione-derived carbon nanodot: Interplay of induced-aggregation and co-solubilization. Int J Biol Macromol. 2018 Feb 7. [Epub ahead of print]

50. Justino AB, Miranda NC, Franco RR, Martins MM, Silva NMD, Espindola FS. Annona muricata Linn. leaf as a source of antioxidant compounds with in vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase, non-enzymatic glycation and lipid peroxidation. Biomed Pharmacother. 2018 Feb 6;100:83-92. [Epub ahead of print]

51. Dong Q, Liang Y, Yan X, Markey SP, Mirokhin YA, Tchekhovskoi DV, Bukhari TH, Stein SE. The NISTmAb tryptic peptide spectral library for monoclonal antibody characterization. MAbs. 2018 Feb 9:0. [Epub ahead of print]

52. Ashraf JM, Ansari MA, Fatma S, Abdullah SMS, Iqbal J, Madkhali A, Hamali AH, Ahmad S, Jerah A, Echeverria V, Barreto GE, Ashraf GM. Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases. Mol Neurobiol. 2018 Feb 8. [Epub ahead of print]

53. Gregório PC, Favretto G, Sassaki GL, Cunha RS, Becker-Finco A, Pecoits-Filho R, Souza WM, Barreto FC, Stinghen AEM. Sevelamer reduces endothelial inflammatory response to advanced glycation end products. Clin Kidney J. 2018 Feb;11(1):89-98.

54. Jabaudon M, Berthelin P, Pranal T, Roszyk L, Godet T, Faure JS, Chabanne R, Eisenmann N, Lautrette A, Belville C, Blondonnet R, Cayot S, Gillart T, Pascal J, Skrzypczak Y, Souweine B, Blanchon L, Sapin V, Pereira B, Constantin JM. Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study. Sci Rep. 2018 Feb 8;8(1):2603.

55. Shen Y, Ding FH, Dai Y, Wang XQ, Zhang RY, Lu L, Shen WF. Reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion. Cardiovasc Diabetol. 2018 Feb 8;17(1):26.

56. Lin JA, Wu CH, Yen GC. Perspective of Advanced Glycation End Products on Human Health. J Agric Food Chem. 2018 Feb 21. [Epub ahead of print]

57. Hu Z, Deng B, Tan X, Gan H, Li C, Nada SS, Sullivan MA, Li J, Jiang X, Li E, Gilbert RG. Diurnal changes of glycogen molecular structure in healthy and diabetic mice. Carbohydr Polym. 2018 Apr 1;185:145-152.

58. Houjeghani S, Kheirouri S, Faraji E, Jafarabadi MA. l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial. Nutr Res. 2018 Jan;49:96-106.

59. Wendel U, Persson N, Risinger C, Bengtsson E, Nodin B, Danielsson L, Welinder C, Nordin Fredrikson G, Jansson B, Blixt O. A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer. PLoS One. 2018 Feb 8;13(2):e0191872. eCollection 2018.

60. Ghelani H, Razmovski-Naumovski V, Pragada RR, Nammi S. Attenuation of Glucose-Induced Myoglobin Glycation and the Formation of Advanced Glycation End Products (AGEs) by (R)-α-Lipoic Acid In Vitro. Biomolecules. 2018 Feb 8;8(1).

61. Hipkiss AR. Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson's Disease. Neurotox Res. 2018 Feb 7. [Epub ahead of print]


March 22, 2018

16

62. Wang B, Yu J, Wang T, Shen Y, Lin D, Xu X, Wang Y. Identification of megakaryocytes as a target of advanced glycation end products in diabetic complications in bone marrow. Acta Diabetol. 2018 Feb 8. [Epub ahead of print]

63. Cao P, Sun J, Sullivan MA, Huang X, Wang H, Zhang Y, Wang N, Wang K. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. Int J Biol Macromol. 2018 Feb 2;111:1133-1139.

64. Gajahi-Soudahomme A, Catan A, Giraud P, Assouan Kouao S, Guerin-Dubourg A, Debussche X, Le Moullec N, Bourdon E, Bravo SB, Paradela-Dobarro B, Alvarez E, Meilhac O, Rondeau P, Couprie J. Glycation of human serum albumin impairs binding to the glucagon-like peptide-1 analogue liraglutide. J Biol Chem. 2018 Feb 2. [Epub ahead of print]

65. Riedinger C, Mendler M, Schlotterer A, Fleming T, Okun J, Hammes HP, Herzig S, Nawroth PP. High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans. J Biol Chem. 2018 Feb 2. [Epub ahead of print]

66. Liu H, Chen X, Zhang D, Wang J, Wang S, Sun B. Effects of Highland Barley Bran Extract Rich in Phenolic Acids on the Formation of N(ε)-Carboxymethyllysine in a Biscuit Model. J Agric Food Chem. 2018 Feb 16. [Epub ahead of print]

67. Twigg SM. Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes. J Cell Commun Signal. 2018 Feb 6. [Epub ahead of print]

68. Kuzan A, Chwiłkowska A, Maksymowicz K, Bronowicka-Szydełko A, Stach K, Pezowicz C, Gamian A. Correction to: Advanced glycation end products as a source of artifacts in immunoenzymatic methods. Glycoconj J. 2018 Feb 7. [Epub ahead of print].

69. Wu B, Yu L, Hu P, Lu Y, Li J, Wei Y, He R. GRP78 protects CHO cells from ribosylation. Biochim Biophys Acta. 2018 Feb 2;1865(4):629-637.

70. Kabel AM, Omar MS, Alhadhrami A, Alharthi SS, Alrobaian MM. Linagliptin potentiates the effect of l-dopa on the behavioural, biochemical and immunohistochemical changes in experimentally-induced Parkinsonism: Role of toll-like receptor 4, TGF-β1, NF-κB and glucagon-like peptide 1. Physiol Behav. 2018 Feb 8;188:108-118.

71. Palma-Duran SA, Kontogianni MD, Vlassopoulos A, Zhao S, Margariti A, Georgoulis M, Papatheodoridis G, Combet E. Serum levels of advanced glycation end-products (AGEs) and the decoy soluble receptor for AGEs (sRAGE) can discriminate non-alcoholic fatty liver disease in age-, sex- and BMI-matched normo-glycemic adults. Metabolism. 2018 Jan 31. [Epub ahead of print]

72. Thomas CJ, Cleland TP, Sroga GE, Vashishth D. Accumulation of carboxymethyl-lysine (CML) in human cortical bone. Bone. 2018 Feb 2;110:128-133.

73. Lin YW. Structure and function of heme proteins regulated by diverse post-translational modifications. Arch Biochem Biophys. 2018 Mar 1;641:1-30.

74. Al-Khazraji BK, Appleton CT, Beier F, Birmingham TB, Shoemaker JK. Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review. Osteoarthritis Cartilage. 2018 Feb 2. [Epub ahead of print]

75. Cosson E, Gary F, Nguyen MT, Bianchi L, Sandre-Banon D, Biri L, Jaber Y, Cussac-Pillegand C, Banu I, Chiheb S, Carbillon L, Valensi P. Gradual increase in advanced glycation end-products from no diabetes to early and regular gestational diabetes: A case-control study. Diabetes Metab. 2018 Feb 2. [Epub ahead of print]

76. Ma H, Johnson SL, Liu W, DaSilva NA, Meschwitz S, Dain JA, Seeram NP. Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free


March 22, 2018

17

Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects. Int J Mol Sci. 2018 Feb 3;19(2).

77. Klaus A, Baldensperger T, Fiedler R, Girndt M, Glomb MA. Influence of Transketolase-Catalyzed Reactions on the Formation of Glycolaldehyde and Glyoxal Specific Posttranslational Modifications under Physiological Conditions. J Agric Food Chem. 2018 Feb 14;66(6):1498-1508.

78. Agawane SB, Gupta VS, Kulkarni MJ, Bhattacharya AK, Koratkar SS. Chemo-biological evaluation of antidiabetic activity of Mentha arvensis L. and it's role in inhibition of advanced glycation end products. J Ayurveda Integr Med. 2018 Feb 2. [Epub ahead of print]

79. Dhulekar J, Simionescu A. Challenges in vascular tissue engineering for diabetic patients. Acta Biomater. 2018 Jan 25. [Epub ahead of print]

80. Peeters SA, Engelen L, Buijs J, Theilade S, Rossing P, Schalkwijk CG, Stehouwer CDA. Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes. J Diabetes Complications. 2018 Mar;32(3):325-329.

81. Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC. Elevations of novel cytokines in bacterial meningitis in infants. PLoS One. 2018 Feb 2;13(2):e0181449. eCollection 2018.

82. Shi Y, Zhang L, Teng J, Miao W. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Mol Med Rep. 2018 Jan 25. [Epub ahead of print]

83. Yang R, Wang WX, Chen HJ, He ZC, Jia AQ. The inhibition of advanced glycation end-products by five fractions and three main flavonoids from Camellia nitidissima Chi flowers. J Food Drug Anal. 2018 Jan;26(1):252-259.

84. Cho HJ, Xie C, Cai H. AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression. Transl Neurodegener. 2018 Jan 23;7:1. eCollection 2018.

85. Tachibana M. [The Immunosuppressive Function of Myeloid-derived Suppressor Cells Is Regulated by the HMGB1-TLR4 Axis]. Yakugaku Zasshi. 2018;138(2):143-148.

86. Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, Shuck SC, Ciminera AK, De Jesus LR, Ouyang C, Chen MY, Termini J. Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. Int J Mol Sci. 2018 Jan 30;19(2).

87. Batkulwar K, Godbole R, Banarjee R, Kassaar O, Williams RJ, Kulkarni MJ. Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease. ACS Chem Neurosci. 2018 Feb 14. [Epub ahead of print]

88. Zhu D, Su Y, Fu B, Xu H. Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis. Mol Neurobiol. 2018 Jan 30. [Epub ahead of print]

89. Kawahara M, Tanaka KI, Kato-Negishi M. Zinc, Carnosine, and Neurodegenerative Diseases. Nutrients. 2018 Jan 29;10(2).

90. Zhu Y, Snooks H, Sang S. Complexity of Advanced Glycation End Products in Foods: Where Are We Now? J Agric Food Chem. 2018 Feb 14;66(6):1325-1329.

91. Siddiqui Z, Ishtikhar M, Moinuddin, Ahmad S. d-Ribose induced glycoxidative insult to hemoglobin protein: An approach to spot its structural perturbations. Int J Biol Macromol. 2018 Jan 31;112:134-147.


March 22, 2018

18

92. Mukai H, Svedberg O, Lindholm B, Dai L, Heimbürger O, Barany P, Anderstam B, Stenvinkel P, Qureshi AR. Skin autofluorescence, arterial stiffness and Framingham risk score as predictors of clinical outcome in chronic kidney disease patients: a cohort study. Nephrol Dial Transplant. 2018 Jan 25. [Epub ahead of print]

93. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J. Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Clin Transplant. 2018 Jan 29. [Epub ahead of print]

94. Kan S, Wu J, Sun C, Hao J, Wu Z. Correlation between RAGE gene promoter methylation and diabetic retinal inflammation. Exp Ther Med. 2018 Jan;15(1):242-246.

95. Mardente S, Mari E, Massimi I, Tafani M, Guerriero R, Morsilli O, Pulcinelli FM, Bianchi ME, Zicari A. From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis. Front Immunol. 2018 Jan 12;8:1946. eCollection 2017.

96. Wang B, Liu T, Wu Z, Zhang L, Sun J, Wang X. Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents. J Enzyme Inhib Med Chem. 2018 Dec;33(1):416-423.

97. Zhang Y, Yang X, Qiu C, Liu F, Liu P, Liu Z. Matrine suppresses AGE-induced HAEC injury by inhibiting ROS-mediated NRLP3 inflammasome activation. Eur J Pharmacol. 2018 Mar 5;822:207-211.

98. Jamwal S, Sharma S. Vascular endothelium dysfunction: a conservative target in metabolic disorders. Inflamm Res. 2018 Jan 25. [Epub ahead of print]

99. Ou J, Huang J, Zhao D, Du B, Wang M. Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats. Food Funct. 2018 Feb 21;9(2):851-860.

100. Lu M, Luo Y, Hu P, Dou L, Huang S. Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling. Iran J Basic Med Sci. 2018 Jan;21(1):83-88.

101. Gawandi S, Gangawane S, Chakrabarti A, Kedare S, Bantwal K, Wadhe V, Kulkarni A, Kulkarni S, Rajan MGR. A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects. Indian J Clin Biochem. 2018 Jan;33(1):81-85.

102. Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis. 2018 Jan 25;9(2):119.

103. Lechuga-Sancho AM, Gallego-Andujar D, Ruiz-Ocaña P, Visiedo FM, Saez-Benito A, Schwarz M, Segundo C, Mateos RM. Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age. PLoS One. 2018 Jan 25;13(1):e0191547. eCollection 2018.

104. Das S, Hussain MS, Maras JS, Kumar J, Shasthry SM, Nayak S, Arora V, Vijayaraghavan R, Sharma S, Maiwall R, Sarin SK. Modification Patterns of Urinary Albumin Correlates With Serum Albumin and Outcome in Severe Alcoholic Hepatitis. J Clin Gastroenterol. 2018 Jan 24. [Epub ahead of print]

105. Sponder M, Campean IA, Emich M, Fritzer-Szekeres M, Litschauer B, Graf S, Dalos D, Strametz-Juranek J. Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity? Heart Vessels. 2018 Jan 24. [Epub ahead of print]

106. Abd El-Salam MH, El-Shibiny S. Glycation of whey proteins: Technological and nutritional implications. Int J Biol Macromol. 2018 Jan 29;112:83-92.

107. Tiefensee Ribeiro C, Gasparotto J, Teixeira AA, Portela LVC, Flores VNL, Moreira JCF, Gelain DP. Immune neutralization of the receptor for advanced glycation


March 22, 2018

19

endproducts reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide. J Biochem. 2018 Jan 22. [Epub ahead of print]

108. Abar O, Dharmar S, Tang SY. The effect of aminoguanidine (AG) and pyridoxamine (PM) on ageing human cortical bone. Bone Joint Res. 2018 Jan;7(1):105-110.

109. Shuck SC, Wuenschell GE, Termini JS. Product Studies and Mechanistic Analysis of the Reaction of Methylglyoxal with Deoxyguanosine. Chem Res Toxicol. 2018 Feb 19;31(2):105-115.

110. Ansari NA, Chaudhary DK, Dash D. Modification of histone by glyoxal: Recognition of glycated histone containing advanced glycation adducts by serum antibodies of type 1 diabetes patients. Glycobiology. 2018 Jan 19. [Epub ahead of print]

111. Aalaei K, Rayner M, Sjöholm I. Chemical methods and techniques to monitor early Maillard reaction in milk products; A review. Crit Rev Food Sci Nutr. 2018 Jan 23:1-11.

112. Panda D, Bai X, Sabbagh Y, Zhang Y, Zaun HC, Karellis A, Koromilas AE, Lipman M, Karaplis AC. Defective Interplay Between mTORC1 Activity and Endoplasmic Reticulum Stress-Unfolded Protein Response in Uremic Vascular Calcification. Am J Physiol Renal Physiol. 2018 Jan 10. [Epub ahead of print]

113. Marinucci L, Balloni S, Fettucciari K, Bodo M, Talesa VN, Antognelli C. Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H(2)O(2) and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis. Free Radic Biol Med. 2018 Jan 20;117:6-17.

114. Tsukahara R, Haniu H, Matsuda Y, Tsukahara T. The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction. Mol Cell Endocrinol. 2018 Jan 20. [Epub ahead of print]

115. Huang YJ, Zhang L, Shi LY, Wang YY, Yang YB, Ke B, Zhang TY, Qin J. Caloric restriction ameliorates acrolein-induced neurotoxicity in rats. Neurotoxicology. 2018 Jan 31;65:44-51. [Epub ahead of print]

116. Khan MA, Arif Z, Khan MA, Moinuddin, Alam K. Methylglyoxal produces more changes in biochemical and biophysical properties of human IgG under high glucose compared to normal glucose level. PLoS One. 2018 Jan 19;13(1):e0191014. eCollection 2018.

117. Al-Sowygh ZH, Ghani SMA, Sergis K, Vohra F, Akram Z. Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control. Clin Implant Dent Relat Res. 2018 Jan 19. [Epub ahead of print]

118. Yang W, Tu Z, Wang H, Zhang L, Song Q. Glycation of ovalbumin after high-intensity ultrasound pretreatment: Effects on conformation, IgG/IgE binding ability and antioxidant activity. J Sci Food Agric. 2018 Jan 18. [Epub ahead of print]

119. Andley UP, Tycksen E, McGlasson-Naumann BN, Hamilton PD. Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract. PLoS One. 2018 Jan 16;13(1):e0190817. eCollection 2018.

120. Abedini A, Cao P, Plesner A, Zhang J, He M, Derk J, Patil SA, Rosario R, Lonier J, Song F, Koh H, Li H, Raleigh DP, Schmidt AM. RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity. J Clin Invest. 2018 Feb 1;128(2):682-698.

121. Ghelani H, Razmovski-Naumovski V, Pragada RR, Nammi S. (R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro. BMC Complement Altern Med. 2018 Jan 15;18(1):13.

122. Pouran B, Moshtagh PR, Arbabi V, Snabel J, Stoop R, Ruberti J, Malda J, Zadpoor AA, Weinans H. Non-enzymatic cross-linking of collagen type II fibrils is tuned via osmolality switch. J Orthop Res. 2018 Jan 15. [Epub ahead of print]


March 22, 2018

20

123. Liao YH, Chen CY, Chen CN, Wu CY, Tsai SC. An Amino Acids Mixture Attenuates Glycemic Impairment but not Affects Adiposity Development in Rats Fed with AGEs-containing Diet. Int J Med Sci. 2018 Jan 1;15(2):176-187. eCollection 2018.

124. Schweitzer C, Cougnard-Gregoire A, Rigalleau V, Dartigues JF, Malet F, Rougier MB, Delyfer MN, Helmer C, Korobelnik JF, Delcourt C. Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):75-84.

125. Volpina OM, Samokhin AN, Koroev DO, Nesterova IV, Volkova TD, Medvinskaya NI, Nekrasov PV, Tatarnikova OG, Kamynina AV, Balasanyants SM, Voronina TA, Kulikov AM, Bobkova NV. Synthetic Fragment of Receptor for Advanced Glycation End Products Prevents Memory Loss and Protects Brain Neurons in Olfactory Bulbectomized Mice. J Alzheimers Dis. 2018;61(3):1061-1076.

126. Kehm R, König J, Nowotny K, Jung T, Deubel S, Gohlke S, Schulz TJ, Höhn A. Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 2018 May;15:387-393.

127. Garud MS, Kulkarni YA. Gallic acid attenuates type I diabetic nephropathy in rats. Chem Biol Interact. 2018 Feb 25;282:69-76.

128. Na M, Mohammad M, Fei Y, Wang W, Holdfeldt A, Forsman H, Ali A, Pullerits R, Jin T. Lack of Receptor for Advanced Glycation End products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound healing. J Infect Dis. 2018 Jan 10. [Epub ahead of print]

129. Fang F, Yu Q, Arancio O, Chen D, Gore SS, Yan SF, Yan SS. RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity. Hum Mol Genet. 2018 Jan 10. [Epub ahead of print]

130. Xiao Z, Yin X, Han L, Sun B, Shen Z, Liu W, Yu F. A comprehensive approach for evaluating charge heterogeneity in biosimilars. Eur J Pharm Sci. 2018 Mar 30;115:19-24.

131. Isami F, West BJ, Nakajima S, Yamagishi SI. Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population. J Int Med Res. 2018 Jan 1:300060517736914. [Epub ahead of print]

132. Choi YJ, Ock SY, Jin Y, Lee JS, Kim SH, Chung Y. Urinary Pentosidine levels negatively associates with trabecular bone scores in patients with type 2 diabetes mellitus. Osteoporos Int. 2018 Jan 10. [Epub ahead of print]

133. Mirlohi MS, Yaghooti H, Shirali S, Aminasnafi A, Olapour S. Increased levels of advanced glycation end products positively correlate with iron overload and oxidative stress markers in patients with β-thalassemia major. Ann Hematol. 2018 Jan 9. [Epub ahead of print]

134. Banevicius M, Vilkeviciute A, Kriauciuniene L, Liutkeviciene R, Deltuva VP. The Association Between Variants of Receptor for Advanced Glycation End Products (RAGE) Gene Polymorphisms and Age-Related Macular Degeneration. Med Sci Monit. 2018 Jan 10;24:190-199.

135. Murakami Y, Fujino T, Hasegawa T, Kurachi R, Miura A, Daikoh T, Usui T, Hayase F, Watanabe H. Receptor for advanced glycation end products (RAGE)-mediated cytotoxicity of 3-hydroxypyridinium derivatives. Biosci Biotechnol Biochem. 2018 Feb;82(2):312-319.

136. Abe K, Misaka T. Food functionality research as a new national project in special reference to improvement of cognitive and locomotive abilities. Biosci Biotechnol Biochem. 2018 Jan 10:1-11.

137. Vanholder R, Pletinck A, Schepers E, Glorieux G. Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update. Toxins (Basel). 2018 Jan 8;10(1).


March 22, 2018

21

138. Birgin E, Gebhardt C, Hetjens S, Fischer S, Rückert F, Reichenberger MA. Extracorporal Shock Wave Therapy Enhances Receptor for Advanced Glycated End-Product-Dependent Flap Survival and Angiogenesis. Ann Plast Surg. 2018 Jan 5. [Epub ahead of print]

139. van Steen SC, Woodward M, Chalmers J, Li Q, Marre M, Cooper ME, Hamet P, Mancia G, Colagiuri S, Williams B, Grobbee DE, DeVries JH; ADVANCE Collaborative Group. Haemoglobin glycation index and risk for diabetes-related complications in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Diabetologia. 2018 Jan 8. [Epub ahead of print]

140. Lévy BI, Taddei S. Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes. Curr Med Res Opin. 2018 Feb 19:1-14. [Epub ahead of print]

141. Sell DR, Nemet I, Liang Z, Monnier VM. Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes. Glycoconj J. 2018 Jan 5. [Epub ahead of print]

142. Kuzan A, Chwiłkowska A, Maksymowicz K, Bronowicka-Szydełko A, Stach K, Pezowicz C, Gamian A. Advanced glycation end products as a source of artifacts in immunoenzymatic methods. Glycoconj J. 2018 Jan 5. [Epub ahead of print]

143. Gyengesi E, Liang H, Millington C, Sonego S, Sirijovski D, Gunawardena D, Dhananjayan K, Venigalla M, Niedermayer G, Münch G. Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. Pharm Res. 2018 Jan 5;35(1):22.

144. Zacharski LR, Shamayeva G, Chow BK. Iron reduction response and demographic differences between diabetics and non-diabetics with cardiovascular disease entered into a controlled clinical trial. Metallomics. 2018 Feb 21;10(2):264-277.

145. Saum K, Campos B, Celdran-Bonafonte D, Nayak L, Sangwung P, Thakar C, Roy-Chaudhury P, Owens AP Iii PhD. Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel-Like Factor 2. J Am Heart Assoc. 2018 Jan 4;7(1).

146. Rasheed S, Sánchez SS, Yousuf S, Honoré SM, Choudhary MI. Drug repurposing: In-vitro anti-glycation properties of 18 common drugs. PLoS One. 2018 Jan 4;13(1):e0190509.

147. Song R, Shi Q, Yang P, Wei R. In vitro membrane damage induced by half-fin anchovy hydrolysates/glucose Maillard reaction products and the effects on oxidative status in vivo. Food Funct. 2018 Feb 21;9(2):785-796.

148. Zhu X, Zhou L, Li R, Shen Q, Cheng H, Shen Z, Zhu H. AGER promotes proliferation and migration in cervical cancer. Biosci Rep. 2018 Jan 30;38(1).

149. Lee S, Piao C, Kim G, Kim JY, Choi E, Lee M. Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury. Eur J Pharm Sci. 2018 Mar 1;114:275-284.

150. Maria Z, Campolo AR, Scherlag BJ, Ritchey JW, Lacombe VA. Dysregulation of insulin-sensitive glucose transporters during insulin resistance-induced atrial fibrillation. Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):987-996.

151. Ramachandra Bhat L, Vedantham S, Krishnan UM, Rayappan JBB. A non-enzymatic two step catalytic reduction of methylglyoxal by nanostructured V(2)O(5) modified electrode. Biosens Bioelectron. 2018 Apr 30;103:143-150.

152. Abbasi S, Gharaghani S, Benvidi A, Rezaeinasab M. New insights into the efficiency of thymol synergistic effect with p-cymene in inhibiting advanced glycation end products: A multi-way analysis based on spectroscopic and electrochemical methods in combination with molecular docking study. J Pharm Biomed Anal. 2018 Feb 20;150:436-451.


March 22, 2018

22

153. Lei X, He J, Ren C, Zhou Y, Chen X, Dou J. Protective effects of the Chinese herbal medicine prescription Zhujing pill on retina of streptozotocin-induced diabetic rats. Biomed Pharmacother. 2018 Feb;98:643-650.

154. Huang J, Wang Y, Yang L, Peng X, Zheng J, Ou S. Effect of maize bran feruloylated oligosaccharides on the formation of endogenous contaminants and the appearance and textural properties of biscuits. Food Chem. 2018 Apr 15;245:974-980.

155. Paulus WJ, Dal Canto E. Distinct Myocardial Targets for Diabetes Therapy in Heart Failure With Preserved or Reduced Ejection Fraction. JACC Heart Fail. 2018 Jan;6(1):1-7.

156. Li N, Yang H, Wang M, Lü S, Zhang Y, Long M. Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling. Mol Biol Cell. 2018 Feb 15;29(4):408-418.

157. Zhang N, Tu Z, Wang H, Liu G, Wang Z, Huang T, Qin X, Xie X, Wang A. Liquid Chromatography High-Resolution Mass Spectrometry Identifies the Glycation Sites of Bovine Serum Albumin Induced by d-Ribose with Ultrasonic Treatment. J Agric Food Chem. 2018 Jan 24;66(3):563-570.

158. Franco RR, da Silva Carvalho D, de Moura FBR, Justino AB, Silva HCG, Peixoto LG, Espindola FS. Antioxidant and anti-glycation capacities of some medicinal plants and their potential inhibitory against digestive enzymes related to type 2 diabetes mellitus. J Ethnopharmacol. 2018 Apr 6;215:140-146.

159. Zhan D, Guo L, Zheng L. Inhibition of the receptor for advanced glycation promotes proliferation and repair of human periodontal ligament fibroblasts in response to high glucose via the NF-κB signaling pathway. Arch Oral Biol. 2018 Mar;87:86-93.

160. Kamdem RST, Wafo P, Dawe A, Nganteng DND, Ogechukwu UB, Rasheed S, Ogechukwu OE, Makhloufi G, Ali Z, Khan IA, Choudhary MI, Janiak C, Proksch P. Bioactive chemical constituents of Duboscia macrocarpa Bocq., and X-ray diffraction study of 11β, 12β-epoxyfriedours-14-en-3α-ol. Fitoterapia. 2018 Mar;125:65-71.

161. Compston J. Type 2 diabetes mellitus and bone. J Intern Med. 2018 Feb;283(2):140-153.

162. Bai W, Zhou J, Zhou N, Liu Q, Cui J, Zou W, Zhang W. Hypoxia-increased RAGE expression regulates chemotaxis and pro-inflammatory cytokines release through nuclear translocation of NF-κ B and HIF1α in THP-1 cells. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2282-2288.

163. Yu G, Liang Y, Zheng S, Zhang H. Inhibition of Myeloperoxidase by N-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress-Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of Stroke. J Pharmacol Exp Ther. 2018 Feb;364(2):311-322.

164. Collier TA, Nash A, Birch HL, de Leeuw NH. Effect on the mechanical properties of type I collagen of intra-molecular lysine-arginine derived advanced glycation end-product cross-linking. J Biomech. 2018 Jan 23;67:55-61.

165. Wang H, Chen F, Du YF, Long Y, Reed MN, Hu M, Suppiramaniam V, Hong H, Tang SS. Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice. Neuropharmacology. 2018 Mar 15;131:143-153.

166. Zhang J, Guo Y, Wang Y, Song L, Zhang R, Du Y. Long-term treadmill exercise attenuates Aβ burdens and astrocyte activation in APP/PS1 mouse model of Alzheimer's disease. Neurosci Lett. 2018 Feb 14;666:70-77.

167. Zhou L, Wang W, Yang C, Zeng T, Hu M, Wang X, Li N, Sun K, Wang C, Zhou J, Ren M, Yan L. GADD45a Promotes Active DNA Demethylation of the MMP-9 Promoter via Base Excision Repair Pathway in AGEs-Treated Keratinocytes and in Diabetic Male Rat Skin. Endocrinology. 2018 Feb 1;159(2):1172-1186.


March 22, 2018

23

168. Ali MY, Jung HA, Jannat S, Choi JS. Dihydroxanthyletin-type coumarins from Angelica decursiva that inhibits the formation of advanced glycation end products and human recombinant aldose reductase. Arch Pharm Res. 2018 Feb;41(2):196-207.

169. Beaudoin GAW, Li Q, Bruner SD, Hanson AD. An unusual diphosphatase from the PhnP family cleaves reactive FAD photoproducts. Biochem J. 2018 Jan 11;475(1):261-272.

170. Al-Hussaini H, Kilarkaje N. Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys. Toxicol Appl Pharmacol. 2018 Jan 15;339:97-109.

171. Chapman S, Mick M, Hall P, Mejia C, Sue S, Abdul Wase B, Nguyen MA, Whisenant EC, Wilcox SH, Winden D, Reynolds PR, Arroyo JA. Cigarette smoke extract induces oral squamous cell carcinoma cell invasion in a receptor for advanced glycation end-products-dependent manner. Eur J Oral Sci. 2018 Feb;126(1):33-40.

172. Chen Z, Chen Q, Huang J, Gong W, Zou Y, Zhang L, Liu P, Huang H. CK2α promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells. Biochem Pharmacol. 2018 Feb;148:41-51.

173. Salimi F, Jafari-Nodooshan S, Zohourian N, Kolivand S, Hamedi J. Simultaneous anti-diabetic and anti-vascular calcification activity of Nocardia sp. UTMC 751. Lett Appl Microbiol. 2018 Feb;66(2):110-117.

174. Yang W, Tu Z, Wang H, Zhang L, Kaltashov IA, Zhao Y, Niu C, Yao H, Ye W. The mechanism of reduced IgG/IgE-binding of β-lactoglobulin by pulsed electric field pretreatment combined with glycation revealed by ECD/FTICR-MS. Food Funct. 2018 Jan 24;9(1):417-425.

175. Koska J, Saremi A, Howell S, Bahn G, De Courten B, Ginsberg H, Beisswenger PJ, Reaven PD; VADT Investigators. Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes. Diabetes Care. 2018 Mar;41(3):570-576.

176. Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E. High mobility group box 1 orchestrates tissue regeneration via CXCR4. J Exp Med. 2018 Jan 2;215(1):303-318.

177. Sternberg Z, Kolb C, Chadha K, Nir A, Nir R, George R, Johnson J, Yu J, Hojnacki D. Fingolimod anti-inflammatory and neuroprotective effects modulation of RAGE axis in multiple sclerosis patients. Neuropharmacology. 2018 Mar 1;130:71-76.

178. Lee KJ, Yoo JW, Kim YK, Choi JH, Ha TY, Gil M. Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-κB pathway. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2195-2201.

179. Nuhn JAM, Perez AM, Schneider IC. Contact guidance diversity in rotationally aligned collagen matrices. Acta Biomater. 2018 Jan 15;66:248-257.

180. Smith KR, Granberry M, Tan MCB, Daniel CL, Gassman NR. Dihydroxyacetone induces G2/M arrest and apoptotic cell death in A375P melanoma cells. Environ Toxicol. 2018 Mar;33(3):333-342.

181. Fei HX, Zhang YB, Liu T, Zhang XJ, Wu SL. Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease. Biosci Biotechnol Biochem. 2018 Jan;82(1):57-64.

182. Mayer O, Seidlerová J, Černá V, Kučerová A, Karnosová P, Hronová M, Wohlfahrt P, Fuchsová R, Filipovský J, Cífková R, Topolčan O, Pešta M. Serum Vitamin D Status,


March 22, 2018

24

Vitamin D Receptor Polymorphism, and Glucose Homeostasis in Healthy Subjects. Horm Metab Res. 2018 Jan;50(1):56-64.

183. Yoshioka K. Skin Autofluorescence is a Noninvasive Surrogate Marker for Diabetic Microvascular Complications and Carotid Intima-Media Thickness in Japanese Patients with Type 2 Diabetes: A Cross-sectional Study. Diabetes Ther. 2018 Feb;9(1):75-85.

184. Kazakov AS, Shevelyova MP, Ismailov RG, Permyakova ME, Litus EA, Permyakov EA, Permyakov SE. Calcium-dependent interaction of monomeric S100P protein with serum albumin. Int J Biol Macromol. 2018 Mar;108:143-148.

185. Kazemi F, Divsalar A, Saboury AA. Structural analysis of the interaction between free, glycated and fructated hemoglobin with propolis nanoparticles: A spectroscopic study. Int J Biol Macromol. 2018 Apr 1;109:1329-1337.

186. Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. Epilepsy Behav. 2018 Jan;78:57-61.

187. Pei Z, Deng Q, Babcock SA, He EY, Ren J, Zhang Y. Inhibition of advanced glycation endproduct (AGE) rescues against streptozotocin-induced diabetic cardiomyopathy: Role of autophagy and ER stress. Toxicol Lett. 2018 Mar 1;284:10-20.

188. Yao Q, Liang Y, Shao Y, Bian W, Fu H, Xu J, Sui L, Yao B, Li M. Advanced glycation end product concentrations in follicular fluid of women undergoing IVF/ICSI with a GnRH agonist protocol. Reprod Biomed Online. 2018 Jan;36(1):20-25.

189. Soh S, Jun JH, Song JW, Shin EJ, Kwak YL, Shim JK. Ethyl pyruvate attenuates myocardial ischemia-reperfusion injury exacerbated by hyperglycemia via retained inhibitory effect on HMGB1. Int J Cardiol. 2018 Feb 1;252:156-162.

190. Wang J, Zou L, Yuan F, Lv L, Tian S, Li Z, Lin H. Inhibition of advanced glycation endproducts during fish sausage preparation by transglutaminase and chitosan oligosaccharides induced enzymatic glycosylation. Food Funct. 2018 Jan 24;9(1):253-262.

191. Tominaga T, Fujioka K, Hijikuro M, Tada T, Nishikawa Y. Mechanism of increased microbial autofluorescence by heat treatment. Lett Appl Microbiol. 2018 Feb;66(2):118-123.

192. Muñiz A, Garcia AH, Pérez RM, García EV, González DE. In Vitro Inhibitory Activity of Acca sellowiana Fruit Extract on End Products of Advanced Glycation. Diabetes Ther. 2018 Feb;9(1):67-74.

193. Lee IS, Jung SH, Kim JS. Polyphenols from Euphorbia pekinensis Inhibit AGEs Formation In Vitro and Vessel Dilation in Larval Zebrafish In Vivo. Planta Med. 2018 Feb;84(3):176-181. doi: 10.1055/s-0043-120447. Epub 2017 Nov 17. PubMed PMID: 29165729.

194. Leu JG, Chiang MH, Chen CY, Lin JT, Chen HM, Chen YL, Liang YJ. Adenine accelerated the diabetic wound healing by PPAR delta and angiogenic regulation. Eur J Pharmacol. 2018 Jan 5;818:569-577.

195. Rabbani N, Thornalley PJ. Glyoxalase 1 Modulation in Obesity and Diabetes. Antioxid Redox Signal. 2018 Jan 2.

196. Borg DJ, Yap FYT, Keshvari S, Simmons DG, Gallo LA, Fotheringham AK, Zhuang A, Slattery RM, Hasnain SZ, Coughlan MT, Kantharidis P, Forbes JM. Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets. 2018 Jan 2;10(1):10-24.

197. Yu X, Tan J, Diamond SL. Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions. J Thromb Haemost. 2018 Feb;16(2):316-329.

198. Niño SA, Martel-Gallegos G, Castro-Zavala A, Ortega-Berlanga B, Delgado JM, Hernández-Mendoza H, Romero-Guzmán E, Ríos-Lugo J, Rosales-Mendoza S,


March 22, 2018

25

Jiménez-Capdeville ME, Zarazúa S. Chronic Arsenic Exposure Increases Aβ((1-42)) Production and Receptor for Advanced Glycation End Products Expression in Rat Brain. Chem Res Toxicol. 2018 Jan 16;31(1):13-21.

199. Chen W, Chan Y, Wan W, Li Y, Zhang C. Aβ(1-42) induces cell damage via RAGE-dependent endoplasmic reticulum stress in bEnd.3 cells. Exp Cell Res. 2018 Jan 1;362(1):83-89.

200. Lee KH, Choi EM. Effects of bergenin on methylglyoxal-induced damage in osteoblastic MC3T3-E1 cells. J Appl Toxicol. 2018 Apr;38(4):585-593.

201. Tang Y, Yu C, Wu J, Chen H, Zeng Y, Wang X, Yang L, Mei Q, Cao S, Qin D. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. Int J Mol Med. 2018 Jan;41(1):251-263.

202. Gligorijević N, Zámorová Križáková M, Penezić A, Katrlík J, Nedić O. Structural and functional changes of fibrinogen due to aging. Int J Biol Macromol. 2018 Mar;108:1028-1034.

203. Xu S, Li L, Yan J, Ye F, Shao C, Sun Z, Bao Z, Dai Z, Zhu J, Jing L, Wang Z. CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration. Biomed Pharmacother. 2018 Jan;97:1020-1031.

204. Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T. Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum Reprod Update. 2018 Jan 1;24(1):86-105.

205. Zaman A, Arif Z, Moinuddin, Alam K. Fructose-human serum albumin interaction undergoes numerous biophysical and biochemical changes before forming AGEs and aggregates. Int J Biol Macromol. 2018 Apr 1;109:896-906.

206. Gasparotto J, Girardi CS, Somensi N, Ribeiro CT, Moreira JCF, Michels M, Sonai B, Rocha M, Steckert AV, Barichello T, Quevedo J, Dal-Pizzol F, Gelain DP. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018 Jan 5;293(1):226-244.

207. Oh S, Son M, Choi J, Lee S, Byun K. sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model. Biochem Biophys Res Commun. 2018 Jan 1;495(1):807-813.

208. Santos G, Barateiro A, Gomes CM, Brites D, Fernandes A. Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment. Neuropharmacology. 2018 Feb;129:69-83.

209. Hu Q, Yu B, Chen Q, Wang Y, Ling Y, Sun S, Shi Y, Zhou C. Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid β related transporters RAGE and LRP 1 in a rat model of Alzheimer's disease. Mol Med Rep. 2018 Jan;17(1):827-834.

210. Pongprayoon P, Mori T. The critical role of dimer formation in monosaccharides binding to human serum albumin. Phys Chem Chem Phys. 2018 Jan 31;20(5):3249-3257.

211. Hudson BI, Lippman ME. Targeting RAGE Signaling in Inflammatory Disease. Annu Rev Med. 2018 Jan 29;69:349-364.

212. Das S, Karn A, Sarmah R, Rohman MA, Koley S, Ghosh P, Roy AS. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

213. Wang Y, Li H, Zhang Y. Understanding the viscoelastic behavior of arterial elastin in glucose via relaxation time distribution spectrum. J Mech Behav Biomed Mater. 2018 Jan;77:634-641.


March 22, 2018

26

214. Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ. Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling. Inflammation. 2018 Feb;41(1):260-275.

215. Iborra RT, Machado-Lima A, Okuda LS, Pinto PR, Nakandakare ER, Machado UF, Correa-Giannella ML, Pickford R, Woods T, Brimble MA, Rye KA, Lu R, Yokoyama S, Passarelli M. AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages. J Diabetes Complications. 2018 Jan;32(1):1-10.

216. Karbasforooshan H, Karimi G. The role of SIRT1 in diabetic retinopathy. Biomed Pharmacother. 2018 Jan;97:190-194.

217. Hause F, Schlote D, Simm A, Hoffmann K, Santos AN. Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice. Biogerontology. 2018 Feb;19(1):95-100.

218. Kashyap SR, Osme A, Ilchenko S, Golizeh M, Lee K, Wang S, Bena J, Previs SF, Smith JD, Kasumov T. Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes. J Clin Endocrinol Metab. 2018 Feb 1;103(2):388-396.

219. Benvidi A, Rezaeinasab M, Gharaghani S, Abbasi S. Monitoring the protective ability of thymoquinone mixture with p-cymene against bovine serum albumin (BSA) glycation: MCR-ALS analysis based on combined spectroscopic and electrochemical methods. Int J Biol Macromol. 2018 Feb;107(Pt B):2465-2474.

220. Moshtagh PR, Korthagen NM, van Rijen MHP, Castelein RM, Zadpoor AA, Weinans H. Effects of non-enzymatic glycation on the micro- and nano-mechanics of articular cartilage. J Mech Behav Biomed Mater. 2018 Jan;77:551-556.

221. Pradeep SR, Srinivasan K. Alleviation of oxidative stress-mediated nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. Food Funct. 2018 Jan 24;9(1):134-148.

222. Tu DG, Chang YL, Chou CH, Lin YL, Chiang CC, Chang YY, Chen YC. Preventive effects of taurine against d-galactose-induced cognitive dysfunction and brain damage. Food Funct. 2018 Jan 24;9(1):124-133.

223. Dunmore SJ, Al-Derawi AS, Nayak AU, Narshi A, Nevill AM, Hellwig A, Majebi A, Kirkham P, Brown JE, Singh BM. Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes. Diabetes. 2018 Jan;67(1):131-136.

224. Itokawa M, Miyashita M, Arai M, Dan T, Takahashi K, Tokunaga T, Ishimoto K, Toriumi K, Ichikawa T, Horiuchi Y, Kobori A, Usami S, Yoshikawa T, Amano N, Washizuka S, Okazaki Y, Miyata T. Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress. Psychiatry Clin Neurosci. 2018 Jan;72(1):35-44.

225. Costa EV, Soares LN, Pinheiro MLB, Maia BHLNS, Marques FA, Barison A, Almeida JRGS, Sousa IL, Galaverna RS, Heerdt G, Morgon NH, Acho LDR, Lima ES, da Silva FMA, Koolen HHF. Guaianolide sesquiterpene lactones and aporphine alkaloids from the stem bark of Guatteria friesiana. Phytochemistry. 2018 Jan;145:18-25.

226. Iacobini C, Menini S, Blasetti Fantauzzi C, Pesce CM, Giaccari A, Salomone E, Lapolla A, Orioli M, Aldini G, Pugliese G. FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice. Br J Pharmacol. 2018 Jan;175(1):53-66.

227. Holik AK, Lieder B, Kretschy N, Somoza MM, Ley JP, Hans J, Somoza V. The advanced glycation end product N(ϵ) -carboxymethyllysine and its precursor glyoxal increase serotonin release from Caco-2 cells. J Cell Biochem. 2018 Mar;119(3):2731-2741.


March 22, 2018

27

228. Arif Z, Neelofar K, Arfat MY, Zaman A, Tarannum A, Parveen I, Ahmad S, Khan MA, Badar A, Islam SN. Hyperglycemia induced reactive species trigger structural changes in human serum albumin of type 1 diabetic subjects. Int J Biol Macromol. 2018 Feb;107(Pt B):2141-2149.

229. Tan B, Shen L, Yang K, Huang D, Li X, Li Y, Zhao L, Chen J, Yi Q, Xu H, Tian J, Zhu J. C6 glioma-conditioned medium induces malignant transformation of mesenchymal stem cells: Possible role of S100B/RAGE pathway. Biochem Biophys Res Commun. 2018 Jan 1;495(1):78-85.

230. Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells. J Biochem. 2018 Feb 1;163(2):143-153.

231. Tamaki J, Kouda K, Fujita Y, Iki M, Yura A, Miura M, Sato Y, Okamoto N, Kurumatani N. Ratio of Endogenous Secretory Receptor for Advanced Glycation End Products to Pentosidine Predicts Fractures in Men. J Clin Endocrinol Metab. 2018 Jan 1;103(1):85-94.

232. Santos-Bezerra DP, Machado-Lima A, Monteiro MB, Admoni SN, Perez RV, Machado CG, Shimizu MH, Cavaleiro AM, Thieme K, Queiroz MS, Machado UF, Giannella-Neto D, Passarelli M, Corrêa-Giannella ML. Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients. Diab Vasc Dis Res. 2018 Jan;15(1):81-89.

233. Fraige K, Dametto AC, Zeraik ML, de Freitas L, Saraiva AC, Medeiros AI, Castro-Gamboa I, Cavalheiro AJ, Silva DHS, Lopes NP, Bolzani VS. Dereplication by HPLC-DAD-ESI-MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae). Phytochem Anal. 2018 Mar;29(2):196-204.

234. Chand SK, Singh RG, Pendharkar SA, Bharmal SH, Petrov MS. Interplay between innate immunity and iron metabolism after acute pancreatitis. Cytokine. 2018 Mar;103:90-98.

235. Wang Y, Zhang W, Zhao H, Wang Y, Lu C, Li X, Wang Y, Xiao Y, Wang Y, Wang B. Fasting blood soluble RAGE may be causally implicated in impaired glucose metabolism in Chinese patients with primary hypertension. Gene. 2018 Jan 10;639:11-17.

236. Katakami N. Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus. J Atheroscler Thromb. 2018 Jan 1;25(1):27-39.

237. Wang B, Yee Aw T, Stokes KY. N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes. Redox Biol. 2018 Apr;14:218-228.

238. Suh KS, Chon S, Choi EM. Cytoprotective effects of xanthohumol against methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells. J Appl Toxicol. 2018 Feb;38(2):180-192.

239. Jiang Y, Shang S, Li P, Chen C, Dang L, Wang J, Huo K, Deng M, Wang J, Qu Q. Pulse pressure is associated with plasma amyloid-β transport dysfunction. J Hypertens. 2018 Mar;36(3):569-579.

240. Sharma I, Tupe RS, Wallner AK, Kanwar YS. Contribution of myo-inositol oxygenase in AGE:RAGE-mediated renal tubulointerstitial injury in the context of diabetic nephropathy. Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F107-F121.

241. Hafsa J, Hammi KM, Cerf DL, Limem K, Majdoub H, Charfeddine B. Characterization, antioxidant and antiglycation properties of polysaccharides extracted from the medicinal halophyte Carpobrotus edulis L. Int J Biol Macromol. 2018 Feb;107(Pt A):833-842.

242. Kandaraki EA, Chatzigeorgiou A, Papageorgiou E, Piperi C, Adamopoulos C, Papavassiliou AG, Koutsilieris M, Diamanti-Kandarakis E. Advanced glycation end


March 22, 2018

28

products interfere in luteinizing hormone and follicle stimulating hormone signaling in human granulosa KGN cells. Exp Biol Med (Maywood). 2018 Jan;243(1):29-33.

243. Suh KS, Chon S, Choi EM. Bergenin increases osteogenic differentiation and prevents methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblasts. Cytotechnology. 2018 Feb;70(1):215-224.

244. Banerjee S. Glyoxal-induced modification enhances stability of hemoglobin and lowers iron-mediated oxidation reactions of the heme protein: An in vitro study. Int J Biol Macromol. 2018 Feb;107(Pt A):494-501.

245. Żurawska-Płaksej E, Rorbach-Dolata A, Wiglusz K, Piwowar A. The effect of glycation on bovine serum albumin conformation and ligand binding properties with regard to gliclazide. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 15;189:625-633.

246. Flückiger R, Cocuzzi E, Nagaraj RH, Shoham M, Kern TS, Medof ME. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol Immunol. 2018 Jan;93:246-252.

247. Franklin TC, Wohleb ES, Zhang Y, Fogaça M, Hare B, Duman RS. Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biol Psychiatry. 2018 Jan 1;83(1):50-60.

248. Fan Y, Yi J, Zhang Y, Yokoyama W. Fabrication of curcumin-loaded bovine serum albumin (BSA)-dextran nanoparticles and the cellular antioxidant activity. Food Chem. 2018 Jan 15;239:1210-1218.

249. Lin DPL, Dass CR. Weak bones in diabetes mellitus - an update on pharmaceutical treatment options. J Pharm Pharmacol. 2018 Jan;70(1):1-17.

250. Ahmad S, Hassan A, Abbasi WM, Rehman T. Phytochemistry and pharmacological potential of Cassia absus - a review. J Pharm Pharmacol. 2018 Jan;70(1):27-41.

251. Chen F, Ghosh A, Hu M, Long Y, Sun H, Kong L, Hong H, Tang S. RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model. Neurotox Res. 2018 Feb;33(2):284-299.

252. Beyer B, Schuster M, Jungbauer A, Lingg N. Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact. Biotechnol J. 2018 Jan;13(1).

253. Dos Santos MM, Prestes AS, de Macedo GT, Ecker A, Barcelos RP, Boligon AA, Souza D, de Bem AF, da Rocha JBT, Barbosa NV. Syzygium cumini leaf extract inhibits LDL oxidation, but does not protect the liproprotein from glycation. J Ethnopharmacol. 2018 Jan 10;210:69-79.

254. Khaki PSS, Feroz A, Siddiqui AA, Qadri SM, Amin F, Bano B. Glycation induced conformational alterations in caprine brain cystatin (CBC) leads to aggregation via passage through a partially folded state. Int J Biol Macromol. 2018 Jan;106:917-929.

255. Khorasani MMY, Andam-Shahsavari P, Zainodini N, Khoramdelazad H, Nosratabadi R. Association of S100 calcium-binding protein A12, receptor for advanced glycation endproducts, and nuclear factor-κB expression with inflammation in pulp tissues from tooth caries. J Investig Clin Dent. 2018 Feb;9(1).

256. Srivastava RAK. Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease. Mol Cell Biochem. 2018 Mar;440(1-2):167-187.

257. Niu C, Han Y, Wang J, Zheng F, Liu C, Li Y, Li Q. Comparative analysis of the effect of protein Z(4) from barley malt and recombinant Pichia pastoris on beer foam stability: Role of N-glycosylation and glycation. Int J Biol Macromol. 2018 Jan;106:241-247.

258. Heimfarth L, Delgado J, Mignori MR, Gelain DP, Moreira JCF, Pessoa-Pureur R. Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling. Arch Toxicol. 2018 Jan;92(1):513-527.


March 22, 2018

29

259. Hiroshima Y, Sakamoto E, Yoshida K, Abe K, Naruishi K, Yamamoto T, Shinohara Y, Kido JI, Geczy CL. Advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide increase calprotectin expression in human gingival epithelial cells. J Cell Biochem. 2018 Feb;119(2):1591-1603.

260. Zhao X, Liao YN, Huang Q. The impact of RAGE inhibition in animal models of bacterial sepsis: a systematic review and meta-analysis. J Int Med Res. 2018 Jan;46(1):11-21.

261. Chen Q, Huang J, Gong W, Chen Z, Huang J, Liu P, Huang H. MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5. Mol Cell Endocrinol. 2018 Jan 15;460:123-133.

262. Allam MM, El Gazzar WB. Exendin-4, a glucagon-like peptide-1 receptor agonist downregulates hepatic receptor for advanced glycation end products in non-alcoholic steatohepatitis rat model. Arch Physiol Biochem. 2018 Feb;124(1):10-17.

263. Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao X, Tian XY, Wong WT, Luo JY, Huang Y. Inhibition of miR-92a Suppresses Oxidative Stress and Improves Endothelial Function by Upregulating Heme Oxygenase-1 in db/db Mice. Antioxid Redox Signal. 2018 Feb 10;28(5):358-370.

264. Minor JM, Rickey LM, Bergenstal RM. Evaluating Interventions and Titrations Using Fasting Blood Glucose. J Diabetes Sci Technol. 2018 Jan;12(1):226-227.

265. Han L, Li F, Yu Q, Li D. In vitro antioxidant and cytoprotective properties of Maillard reaction products from phloridzin-amino acid model systems. J Sci Food Agric. 2018 Jan;98(2):590-597.

266. Panwar P, Butler GS, Jamroz A, Azizi P, Overall CM, Brömme D. Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases. Matrix Biol. 2018 Jan;65:30-44.

267. Syed A, Zhu Q, Smith EA. Lateral diffusion and signaling of receptor for advanced glycation end-products (RAGE): a receptor involved in chronic inflammation. Eur Biophys J. 2018 Jan;47(1):39-48.

268. Downs CA, Dang VD, Johnson NM, Denslow ND, Alli AA. Hydrogen Peroxide Stimulates Exosomal Cathepsin B Regulation of the Receptor for Advanced Glycation End-Products (RAGE). J Cell Biochem. 2018 Jan;119(1):599-606.

269. Curzytek K, Kubera M, Trojan E, Wójcik K, Basta-Kaim A, Detka J, Maes M, Rygula R. The effects of pessimism on cell-mediated immunity in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt C):295-303.

270. Maciążek-Jurczyk M, Szkudlarek A, Chudzik M, Pożycka J, Sułkowska A. Alteration of human serum albumin binding properties induced by modifications: A review. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:675-683.

271. Miyamoto H, Kohzuma T, Ohnishi A. Changes in the albumin glycation site, plasma pentosidine and esRAGE concentrations before and after intensive diabetic treatment in patients with abnormally high glycated albumin levels. Ann Clin Biochem. 2018 Jan;55(1):84-91.

272. Vasto S, Accardi G, Aiello A, Di Gaudio F, Barera A, Indelicato S, Galimberti D, Italiano E, Monastero R, Rizzo C, Caruso C, Candore G. Dietary Supplements as Surrogate of Mediterranean Diet in Healthy Smoking Subjects. Rejuvenation Res. 2018 Feb;21(1):37-43.

273. Zhao X, Liao YN, Huang Q. Small interfering RNA targeting receptor for advanced glycation end products protects the rats from multibacterial sepsis. Ir J Med Sci. 2018 Feb;187(1):225-229.

274. Siddhartha VT, Pindiprolu SKSS, Chintamaneni PK, Tummala S, Nandha Kumar S. RAGE receptor targeted bioconjuguate lipid nanoparticles of diallyl disulfide for improved apoptotic activity in triple negative breast cancer: in vitro studies. Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):387-397.


March 22, 2018

30

275. Kuo HL, Huang CC, Lin TY, Lin CY. IL-17 and CD40 ligand synergistically stimulate the chronicity of diabetic nephropathy. Nephrol Dial Transplant. 2018 Feb 1;33(2):248-256.

276. Gąsiorowski K, Brokos B, Echeverria V, Barreto GE, Leszek J. RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration. Mol Neurobiol. 2018 Feb;55(2):1463-1476.

277. Moris D, Theocharis S, Davakis S, Patelis N, Agrogiannis G, Vlachos IS, Spartalis E, Athanasiou A, Bakoyiannis C, Perrea DN, Georgopoulos S. Serum Calprotectin as a Novel Biomarker in Abdominal Aortic Aneurysm Pathogenesis and Progression: Preliminary Data from Experimental Model in Rats. Curr Vasc Pharmacol. 2018 Jan 26;16(2):168-178.

278. Gonzalez-Reyes RE, Rubiano MG. Astrocyte´s RAGE: More Than Just a Question of Mood. Cent Nerv Syst Agents Med Chem. 2018 Jan 26;18(1):39-48.

279. Gupta RK, Gupta K, Sharma A, Das M, Ansari IA, Dwivedi PD. Maillard reaction in food allergy: Pros and cons. Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):208-226.

Documents

IMARS HIGHLIGHTS · Otto Heinrich Warburg, Nobel prize winner (1931) a German physiologist, found that cancer tissues consume large amounts of glucose compared to normal tissue and