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Imaging in the Courtroom:Alchemy is Back in Vogue
University of Denver Sturm College of Law 3/4/2011
Jonathan D. Brodie, Ph.D., M.D.
Dept. of Psychiatry
© 2011 Jonathon D. Brodie
What is an Image?
the vivid representation of anatomy or physiology
the pictorial or graphic display of data Images are sexy, can convey an
enormous amount of information AND can be used in a courtroom
© 2011 Jonathon D. Brodie
Anonymous Defense Attorney:
Images are sexy
Anonymous Defense Attorney:
Images are sexy
© 2011 Jonathon D. Brodie
Normal Control
Methamphetamine Abuser
© 2011 Jonathon D. Brodie
PET Imaging of Amyloid Deposits in Alzheimer’s Disease vs Normal Controls
Source: Klunk, et al. Ann Neurol 2004: 55:306-319.
PET imaging with a novel tracer, Pittsburgh Compound-B (PIB), can provide quantitative information on amyloid deposits in living subjects.
© 2011 Jonathon D. Brodie
Principles of Neuroimaging (I)
Objective is to detect some property of the brain (as measured by attenuation of x-rays, magnetic moments or dipoles, electrical signals, radioactive events) without invading it
Recognize that each imaging technique has a characteristic sensitivity, precision, accuracy and fidelity with respect to a physical and/or physiological process and generally in an artificial environment divorced from the very circumstances and behaviors that engendered the test.
© 2011 Jonathon D. Brodie
Structural ImagingCAT
X-Ray
MRI
Anatomy
CAT
X-Ray
MRI
© 2011 Jonathon D. Brodie
Computerized Tomography (CT) Imaging
(Similar image reconstruction, but based on absorption of x-rays)
© 2011 Jonathon D. Brodie
Proton density, recovery (T1) and decay (T2 and T2*) times.
• By ‘weighting’ the pulse sequence (and point at which data is collected) different images of the brain are obtained
• Weighting is achieved by manipulating TE (time to echo) and TR (time to repetition of the pulse sequence)
T1 weighted Density weighted T2 weighted
© 2011 Jonathon D. Brodie
Functional Imaging
PET
f MRI
EEGFunction
© 2011 Jonathon D. Brodie
f MRI Paradigms (VF & Pharm)
© 2011 Jonathon D. Brodie
fMRI Setup
© 2011 Jonathon D. Brodie
Statistical Mapsuperimposed on
anatomical MRI image
~2s
Functional images
Time
Condition 1
Condition 2 ...
~ 5 min
Time
fMRISignal
(% change)
ROI Time Course
Condition
Activation Statistics
Region of interest (ROI)
© 2011 Jonathon D. Brodie
f MRI from Stimulus to Publication
Courtesy SPM-Website © 2011 Jonathon D. Brodie
K-Space – an MRI literature name for Fourier
space
Source: Traveler’s Guide to K-space (C.A. Mistretta)http://www.cis.rit.edu/htbooks/mri/ © 2011 Jonathon D. Brodie
PET Function
© 2011 Jonathon D. Brodie
Imaging Alcohol’s Effects on the Human Brain
FDG/PET scan demonstrates acute reductions of brain metabolism with alcohol intoxication. ( Volkow et al)
sober
intoxicated
Same subjectO
HOHO OH
OH
18F
© 2011 Jonathon D. Brodie
Principles of Neuroimaging (II)
Applying a model to interpret the signal
Interpreting the reconstructed data in an experimental context or design
Statistical analysis and comparisons
Experimental conclusions or clinical inferences
© 2011 Jonathon D. Brodie
PET Analysis by within subject Subtraction:
Individual Variance and Mean Difference
Stimulation: flickering checkerboardControl: blank screen
© 2011 Jonathon D. Brodie
Even Identical twins are not the same
© 2011 Jonathon D. Brodie