Imagine - Spring 2012 - University of Chicago Medicine

Imagine reaching deep into the lungs to detect

and heal without surgery

Targeting lung cancer

VOLUME 1 SPRING 2012

ALSO INSIDE

Collaboration expands optionsfor patients with heart failure

Imagine being awake while undergoing brain surgery

Kids Health Expert help for kids who can’t sleep: New at-home studies to diagnose sleep disorders

The University of Chicago Medicine

from Overseas

A Special Place for Kids

AdoptedOUR ADOPTION CENTER PROVIDES EXPERTISE, SUPPORT FOR FAMILIES

GREETINGS FROM THE FOREFRONT OF MEDICINE,

Welcome to Imagine, our new quarterly magazine to keep you updated on all that’s happening at the University of Chicago Medicine.

To be at the forefront of medicine requires the best minds working in collaboration, imagining and exploring the possibilities of curing and preventing disease. Our physicians and researchers go beyond “what if” and lead the way in making state-of-the-art diagnoses and treatments available to patients throughout the Chicago area and different parts of the world.

It’s an exciting time at the University of Chicago Medicine, as we will open a brand new hospital in less than a year. We imagined a setting where the patient always comes first, where world-class expertise and research give patients hope and where compassion is threaded through everything we do. This new 10-story hospital will transform the patient experience and serve as an inspiration as our physicians and researchers perform the most complex specialty care. It is truly at the forefront of care and discovery.

In this issue of Imagine, you will read about how the University of Chicago Medicine is addressing the greatest health challenges in lung cancer, end-stage heart disease, brain tumors and children’s sleep problems. You will meet some extraordinary physicians and clinicians who are solving the problems of heart defibrillators, helping parents who have adopted overseas keep their children healthy, and even one who has written a play about community violence.

And in each issue we’ll introduce you to our wonderful South Side community, where the arts, science, architecture, music and more are burgeoning. In this issue, we feature our long-time partner in scientific endeavors, the world-renowned Museum of Science and Industry.

Being part of the prestigious University of Chicago means our physicians and researchers are collaborating with other scientists and researchers to imagine what is possible on behalf of our patients and community.

We are proud to share our stories with you. Thank you for your support. We hope you enjoy learning more about us.

L ast August, Chicagoans Patrick and Erin Rams traveled to Ethiopia to pick up their daughter, a beautiful little girl whose name means “blessing.”

�e first few weeks at home weren’t easy. Bereket was 4½ years old and didn’t speak any English. “Her world was flipped upside down,” Erin Rams said.

Fortunately, the family found a doctor who not only understood but knew how to help. Medical Director Larry Gray, MD, and his team at the Adoption Center at the University of Chicago Medicine’s Comer Children’s Hospital are experts on the medical and emotional needs of children adopted from overseas.

“It’s an amazing support system,” Patrick Rams said.�e center provides its highly specialized care in a warm,

child-friendly setting. Many children arrive with medical problems rarely seen in the U.S., such as extreme malnourish-ment. Gray recalls one child who had been here more than a year and had gained virtually no weight. “�ey called us, and we found the parasite others weren’t familiar with,” he said.

“We take care of the medical issues, but it’s not a disease-oriented or medical model,” Gray said. “�at’s unusual in a medical center.” Indeed, the theme of a family’s first

visit is “Celebration.”Today, Bereket is thriving. In short order, she not only

learned English but has blossomed into one of the most popular preschoolers in her class.

Gray also provides pre-adoption consultations. He reviews medical records from the orphanage, counsels couples on relevant health issues and even gives them his phone number to take on their trip.

“I have been humbled by the number of families who open up their homes to kids who have significant medical and developmental needs and are languishing in foreign orphan-ages,” Gray said.

Chris and Sue Stepaniak’s little boy Jack, 2, was born with a rare bladder defect that will require a series of complex surgeries. When the Western Springs, Ill., couple brought him home from Russia in October, he weighed only 17 pounds. Now he is rocketing up the growth charts.

“Not only has he learned to walk here, but now he walks around the house telling the dog off,” Gray said, grinning.

For more information or to make an appointment, please visit adoption.uchicago.edu or call 1-888-UCH-0200.

240 private inpatient rooms in our

new hospital, opening in January 2013

1 of only 40National Cancer

Institute-designated comprehensive cancer

centers in the U.S.

Melissa Gilliam, MD, MPH, chief of family planning, professor of obstetrics/gynecology and pediatrics, and associate dean for diversity, was recognized for her work to prevent teen pregnancy and address the societal problems that contribute to it.

21 adult and pediatric specialties

ranked among the best in the nation by

U.S. News & World Report

Bereket Rams and Larry Gray, MD

The University of Chicago Medicine and Biological Sciences has been at the forefront of medical care, research and teaching for more than 90 years. Located in historic Hyde Park on the South Side of Chicago, the University of Chicago Medicine and Biological Sciences includes:

Patient Care:

Bernard A. Mitchell Hospital (adult)

Comer Children’s Hospital

Duchossois Center for Advanced Medicine

Numerous outpatient locations throughout the Chicago area

Teaching Programs:

Pritzker School of Medicine

Master’s and doctoral degree programs

Postdoctoral programs

Research:

Medical and basic science units

Among our many honors and acknowledgements: 12 Nobel laureates; ranked 10th of all U.S. medical schools; one of only 40 National Cancer Institute-designated comprehensive cancer centers; 21 adult and pediatric specialties ranked among the best in the country by U.S. News & World Report; ranked second in nation for National Institutes of Health grant support per researcher.

University of Chicago Medicine and Biological Sciences Executive Leadership

Kenneth S. Polonsky, MD, Dean of the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical Affairs for the University of Chicago

Sharon O’Keefe, president of the University of Chicago Medical Center

Richard Baron, MD, dean for clinical practice, chair of the University of Chicago Medicine Department of Radiology

T. Conrad Gilliam, PhD, dean for research and graduate education, Biological Sciences Division

Holly J. Humphrey, MD, dean for medical education, Pritzker School of Medicine

Imagine is published quarterly by the University of Chicago Medicine.

Editors:

Ginny Lee-Herrmann

Anna Madrzyk

Email us at: [email protected]

Design: Group Chicago

Contributing writers: Laura Ramos Hegwer, Diane Kastiel, JoAnn Milivojevic, Rob Mitchum, Stephen Phillips, Anita Slomski and Mary Wroblewski

Contributing photographers: Andrew Campbell, David Christopher, Megan Doherty, Bart Harris, Jean Lachat, Bruce Powell and Victor Powell

Address:

The University of Chicago Medicine5841 S. Maryland Ave.Chicago, IL 60637

Comer Children’s Hospital at the University of Chicago Medicine5721 S. Maryland Ave.Chicago, IL 60637

Telephone: 1-773-702-1000

Appointments: 1-888-UCH-0200

Follow the University of Chicago Medicine on Twitter at twitter.com/UChicagoMed or visit our Facebook page at facebook.com/UChicagoMed. You can read more about our news and research at uchospitals.edu/news and at sciencelife.uchospitals.edu.

This publication does not provide medical advice or treatment suggestions. If you have medical problems or concerns, contact a physician who will determine your treatment. Do not delay seeking medical advice because of something you read here. For urgent needs, call 911 right away.

Kenneth S. Polonsky, MD

Dean of the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical Affairs for the University of Chicago

Sharon O’Keefe

President of the University of Chicago Medical Center

uchospitals.edu uchicagokidshospital.org IMAGINE 3IMAGINE SPRING 2012 The University of Chicago Medicine 1-888-UCH-0200

By the Numbers

887 physicians ranked among the best of the best in Chicago

magazine’s 2012 Top Doctors issue

from Overseas

A Special Place for Kids

AdoptedOUR ADOPTION CENTER PROVIDES EXPERTISE, SUPPORT FOR FAMILIES

GREETINGS FROM THE FOREFRONT OF MEDICINE,

Welcome to Imagine, our new quarterly magazine to keep you updated on all that’s happening at the University of Chicago Medicine.

To be at the forefront of medicine requires the best minds working in collaboration, imagining and exploring the possibilities of curing and preventing disease. Our physicians and researchers go beyond “what if” and lead the way in making state-of-the-art diagnoses and treatments available to patients throughout the Chicago area and different parts of the world.

It’s an exciting time at the University of Chicago Medicine, as we will open a brand new hospital in less than a year. We imagined a setting where the patient always comes first, where world-class expertise and research give patients hope and where compassion is threaded through everything we do. This new 10-story hospital will transform the patient experience and serve as an inspiration as our physicians and researchers perform the most complex specialty care. It is truly at the forefront of care and discovery.

In this issue of Imagine, you will read about how the University of Chicago Medicine is addressing the greatest health challenges in lung cancer, end-stage heart disease, brain tumors and children’s sleep problems. You will meet some extraordinary physicians and clinicians who are solving the problems of heart defibrillators, helping parents who have adopted overseas keep their children healthy, and even one who has written a play about community violence.

And in each issue we’ll introduce you to our wonderful South Side community, where the arts, science, architecture, music and more are burgeoning. In this issue, we feature our long-time partner in scientific endeavors, the world-renowned Museum of Science and Industry.

Being part of the prestigious University of Chicago means our physicians and researchers are collaborating with other scientists and researchers to imagine what is possible on behalf of our patients and community.

We are proud to share our stories with you. Thank you for your support. We hope you enjoy learning more about us.

L ast August, Chicagoans Patrick and Erin Rams traveled to Ethiopia to pick up their daughter, a beautiful little girl whose name means “blessing.”

�e first few weeks at home weren’t easy. Bereket was 4½ years old and didn’t speak any English. “Her world was flipped upside down,” Erin Rams said.

Fortunately, the family found a doctor who not only understood but knew how to help. Medical Director Larry Gray, MD, and his team at the Adoption Center at the University of Chicago Medicine’s Comer Children’s Hospital are experts on the medical and emotional needs of children adopted from overseas.

“It’s an amazing support system,” Patrick Rams said.�e center provides its highly specialized care in a warm,

child-friendly setting. Many children arrive with medical problems rarely seen in the U.S., such as extreme malnourish-ment. Gray recalls one child who had been here more than a year and had gained virtually no weight. “�ey called us, and we found the parasite others weren’t familiar with,” he said.

“We take care of the medical issues, but it’s not a disease-oriented or medical model,” Gray said. “�at’s unusual in a medical center.” Indeed, the theme of a family’s first

visit is “Celebration.”Today, Bereket is thriving. In short order, she not only

learned English but has blossomed into one of the most popular preschoolers in her class.

Gray also provides pre-adoption consultations. He reviews medical records from the orphanage, counsels couples on relevant health issues and even gives them his phone number to take on their trip.

“I have been humbled by the number of families who open up their homes to kids who have significant medical and developmental needs and are languishing in foreign orphan-ages,” Gray said.

Chris and Sue Stepaniak’s little boy Jack, 2, was born with a rare bladder defect that will require a series of complex surgeries. When the Western Springs, Ill., couple brought him home from Russia in October, he weighed only 17 pounds. Now he is rocketing up the growth charts.

“Not only has he learned to walk here, but now he walks around the house telling the dog off,” Gray said, grinning.

For more information or to make an appointment, please visit adoption.uchicago.edu or call 1-888-UCH-0200.

240 private inpatient rooms in our

new hospital, opening in January 2013

1 of only 40National Cancer

Institute-designated comprehensive cancer

centers in the U.S.

Melissa Gilliam, MD, MPH, chief of family planning, professor of obstetrics/gynecology and pediatrics, and associate dean for diversity, was recognized for her work to prevent teen pregnancy and address the societal problems that contribute to it.

21 adult and pediatric specialties

ranked among the best in the nation by

U.S. News & World Report

Bereket Rams and Larry Gray, MD

The University of Chicago Medicine and Biological Sciences has been at the forefront of medical care, research and teaching for more than 90 years. Located in historic Hyde Park on the South Side of Chicago, the University of Chicago Medicine and Biological Sciences includes:

Patient Care:

Bernard A. Mitchell Hospital (adult)

Comer Children’s Hospital

Duchossois Center for Advanced Medicine

Numerous outpatient locations throughout the Chicago area

Teaching Programs:

Pritzker School of Medicine

Master’s and doctoral degree programs

Postdoctoral programs

Research:

Medical and basic science units

Among our many honors and acknowledgements: 12 Nobel laureates; ranked 10th of all U.S. medical schools; one of only 40 National Cancer Institute-designated comprehensive cancer centers; 21 adult and pediatric specialties ranked among the best in the country by U.S. News & World Report; ranked second in nation for National Institutes of Health grant support per researcher.

University of Chicago Medicine and Biological Sciences Executive Leadership

Kenneth S. Polonsky, MD, Dean of the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical Affairs for the University of Chicago

Sharon O’Keefe, president of the University of Chicago Medical Center

Richard Baron, MD, dean for clinical practice, chair of the University of Chicago Medicine Department of Radiology

T. Conrad Gilliam, PhD, dean for research and graduate education, Biological Sciences Division

Holly J. Humphrey, MD, dean for medical education, Pritzker School of Medicine

Imagine is published quarterly by the University of Chicago Medicine.

Editors:

Ginny Lee-Herrmann

Anna Madrzyk

Email us at: [email protected]

Design: Group Chicago

Contributing writers: Laura Ramos Hegwer, Diane Kastiel, JoAnn Milivojevic, Rob Mitchum, Stephen Phillips, Anita Slomski and Mary Wroblewski

Contributing photographers: Andrew Campbell, David Christopher, Megan Doherty, Bart Harris, Jean Lachat, Bruce Powell and Victor Powell

Address:

The University of Chicago Medicine5841 S. Maryland Ave.Chicago, IL 60637

Comer Children’s Hospital at the University of Chicago Medicine5721 S. Maryland Ave.Chicago, IL 60637

Telephone: 1-773-702-1000


Follow the University of Chicago Medicine on Twitter at twitter.com/UChicagoMed or visit our Facebook page at facebook.com/UChicagoMed. You can read more about our news and research at uchospitals.edu/news and at sciencelife.uchospitals.edu.

This publication does not provide medical advice or treatment suggestions. If you have medical problems or concerns, contact a physician who will determine your treatment. Do not delay seeking medical advice because of something you read here. For urgent needs, call 911 right away.

Kenneth S. Polonsky, MD

Dean of the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical Affairs for the University of Chicago

Sharon O’Keefe

President of the University of Chicago Medical Center


By the Numbers

87 physicians ranked among the best of the best in Chicago

magazine’s 2012 Top Doctors issue

Living Well with Diabetes: Sunday Brunch with the Experts11 a.m., Sunday, May 6Duchossois Center for Advanced Medicine5758 S. Maryland Ave., ChicagoKovler Diabetes Center’s sixth annual “Living Well with Diabetes” community event features Food Network chef Michael Digby, NBC 5 fitness expert Andrea Metcalf and diabetes experts from the University of Chicago Medicine. The free event includes a healthy brunch, food demonstration, Q&A and goodie bag. Cosponsored by the Urban Health Initiative. Seating is limited; register by May 1.

National Cancer Survivors DayNoon to 3 p.m., Sunday, June 3Westin Hotel Wellington Ballroom909 N. Michigan Ave., ChicagoJoin us for an afternoon of sharing, encouragement and family fun. Featured speakers are David H. Song, MD, MBA, chief of plastic and reconstructive surgery at the University of Chicago Medicine; fashion designer Barbara Bates, a breast cancer survivor; and master of ceremonies Mary Ann Childers. The free event includes music, refreshments and children’s activities. Register by May 31.

What Every Man Should Know About Testicular Cancer6:30 to 7:30 p.m., Wednesday, June 6Gilda’s Club Chicago537 N. Wells St., ChicagoNine out of 10 cases of testicular cancer occur in men between the ages of 20 and 54, the American Cancer Society reports. Join Walter M. Stadler, MD, director of the Genitourinary Program at the University of Chicago Medicine and named one of Chicago magazine’s top doctors, for a discussion on early detection and treatment strategies for this highly curable malignancy.

IMAGINE THAT!

F ifty-two-year-old businessman and avid baseball player Laurence Cavanaugh wasn’t ready to hang up his glove after a dive for the ball led to a fractured shoulder and torn ligaments. “Fortunately,” said Cavanaugh, “it wasn’t my throwing arm.”

�ankfully, his decision to see J. Martin Leland III, MD, sports medicine and orthopaedic surgeon at the University of Chicago Medicine, got him back on the field in relatively short order, after minimally invasive surgery to repair the damage from that great play.

Leland, who practices in Hyde Park and in Matteson, Ill., specializes in the joints that are most commonly injured in

sports — shoulders and knees.His first step was to recommend

physical therapy for Cavanaugh, who lives in Crown Point, Ind. �at helped the bone heal. �e next step was to fix the problems in the joint. Leland repaired the tissues using an arthroscope, a slim instrument inserted into the joint through a small incision.

Leland, who conducts ongoing research to find state-of-the-art treatments, is a sought-after educator and lecturer, offering his expertise to students, physicians and athletic trainers across Chicagoland.

His practice includes some of the most complex sports medicine surgeries,

Kenneth S. Polonsky, MD, is Dean of the Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical A�airs. He also is a leading diabetes researcher.

<conversation>with the Dean

>> What’s new at the University of Chicago Medicine?As we prepare for the opening of our new hospital in January 2013, we are transforming the patient experience to deliver compassionate, expert care with ease of access and state-of-the-art technology. It’s not only a magnificent facility, but a setting that provides support for our clinicians and staff to do their best work. And we have teams working on all the details of your visit, from additional parking we’re planning to new signage that will make it easy to get where you or your family need to be.

>> How does the new building re�ect the commitment to compassionate patient care?Many of our patients face complicated procedures and extended stays. �e new hospital will have private rooms spacious enough for family members to comfortably spend the night. And the nights can be tranquil and quiet, thanks to blackout shades and a state-of-the-art communications system that does not rely on overhead paging. �e building also will support very advanced technology for day-to-day care of patients with complex diseases.

>> What inspires you about the University of Chicago Medicine?Every day, I’m inspired by our brilliant, dedicated physi-

cians, researchers and care teams who collaborate to heal, to teach, to discover and to solve even the most difficult and challenging cases.

>> What makes you excited about the future?We are ideally positioned to be among the leaders in translational research, and therefore patient care, as we translate basic discoveries made in the laboratory into bedside care. �at means our patients often have access to innovative treatments before they are widely available.

>> Tell us about diabetes research at the University of Chicago Medicine.�e University of Chicago has a rich history of diabetes research dating back more than 100 years. Our ground-breaking work on the genetics of diabetes has received international recognition. We are at the forefront of customized diabetes diagnosis and treatment based on genetics, as well as research that may lead to novel therapies for this common disease.

To register for community events, please call 1-888-UCH-0200.

To view videos about orthopaedic injury prevention and treatment, please go to uchospitals.edu/specialties/ orthopaedic-surgery/video.html.

uchospitals.edu/physicians/j-martin-leland.html

twitter.com/DrMartinLeland

Getting Back in theGameOrthopaedic surgeon specializes in minimally invasive surgery for sports injuries

J. Martin Leland III, MD

Helping Your Fellow RatCalling someone a rat is no compliment. Maybe it should be. A team of University of Chicago neuroscientists found rats show empathy for

fellow rats in distress. In the study, published in Science, rats repeatedly acted to free fellow rats from a clear plastic tube. And

they were equally likely to free their cage mates as they were to nudge open a tube �lled with chocolate chips, a favorite treat. “This is the �rst evidence of helping behavior triggered by empathy in rats,” said Jean Decety, PhD.

Secrets to Living to 100People born in September, October or November have higher odds of cracking the century mark, a new study found. Seasonal di�erences in diet

and infection rates may be why. In past studies, researchers Leonid A. Gavrilov, PhD, and Natalia S. Gavrilova, PhD, of the University of Chicago’s Center on Aging, also found that chances for longevity are higher for people born to young mothers, those who have a slender or medium build at age 30 or who are farmers or spend their childhoods on a farm.

Time to Try Diet, Exercise FirstMiddle-aged adults recently diagnosed with diabetes and hypertension have time to learn how to control their high blood pressure without medication, but not too much time. The consequences of delaying e�ective hypertension treatment for up to a year were small — a two-day reduction in quality-adjusted life expectancy, University of Chicago Medicine researchers found. “Our results indicate that it’s OK to spend from six months

to a year, perhaps even longer, to make the di�cult lifestyle changes that are necessary and will pay o� in the long run,” said study author Neda Laiteerapong, MD.

Finding a Fin-Limb LinkUniversity of Chicago professor Neil Shubin’s 2004 discovery of the fossil Tiktaalik roseae made National Geographic’s list of 10 projects “that have made the greatest di�erence in understanding the Earth” — out of 10,000 projects the magazine has funded to date. Tiktaalik, which has �shlike features with limb joints, provided the missing link between �sh and the �rst animals that walked on land.

Read more at sciencelife.uchospitals.edu.


including multiligament knee reconstruc-tions and proximal hamstring repairs.

Leland’s experience and expertise also help patients quickly sort through the best treatment options — from the simple to the complex.

Whether your sport is downhill skiing, golf, volleyball or baseball, chances are you can’t escape a few aches and pains. Of course, not all injuries require surgery. A lot can heal through time and nonsurgical treatments.

“About 90 percent of my patients are nonoperative,” said Leland, former team physician for the Chicago Blackhawks. “My role is to help educate them on what’s going on in their body and how to continue being active without causing further damage.”

Nearly all of Leland’s surgeries are arthroscopic. �e small incisions signifi-cantly reduce pain and speed healing. Leland also works closely with physical therapists during rehabilitation. “I use very structured rehabilitation protocols and strength measurements to get patients to recover as quickly as possible,” he said.

Most patients can expect to return to full activities in anywhere from two weeks to six months, depending on the extent of the injury, Leland said.

As for Cavanaugh, he was happily back in center field just a few months after his surgery.

IMAGINE_4_5_FCv9_4C.pdf 1 4/11/12 2:33 PM

Living Well with Diabetes: Sunday Brunch with the Experts11 a.m., Sunday, May 6Duchossois Center for Advanced Medicine5758 S. Maryland Ave., ChicagoKovler Diabetes Center’s sixth annual “Living Well with Diabetes” community event features Food Network chef Michael Digby, NBC 5 fitness expert Andrea Metcalf and diabetes experts from the University of Chicago Medicine. The free event includes a healthy brunch, food demonstration, Q&A and goodie bag. Cosponsored by the Urban Health Initiative. Seating is limited; register by May 1.

National Cancer Survivors DayNoon to 3 p.m., Sunday, June 3Westin Hotel Wellington Ballroom909 N. Michigan Ave., ChicagoJoin us for an afternoon of sharing, encouragement and family fun. Featured speakers are David H. Song, MD, MBA, chief of plastic and reconstructive surgery at the University of Chicago Medicine; fashion designer Barbara Bates, a breast cancer survivor; and master of ceremonies Mary Ann Childers. The free event includes music, refreshments and children’s activities. Register by May 31.

What Every Man Should Know About Testicular Cancer6:30 to 7:30 p.m., Wednesday, June 6Gilda’s Club Chicago537 N. Wells St., ChicagoNine out of 10 cases of testicular cancer occur in men between the ages of 20 and 54, the American Cancer Society reports. Join Walter M. Stadler, MD, director of the Genitourinary Program at the University of Chicago Medicine and named one of Chicago magazine’s top doctors, for a discussion on early detection and treatment strategies for this highly curable malignancy.

IMAGINE THAT!

F ifty-two-year-old businessman and avid baseball player Laurence Cavanaugh wasn’t ready to hang up his glove after a dive for the ball led to a fractured shoulder and torn ligaments. “Fortunately,” said Cavanaugh, “it wasn’t my throwing arm.”

�ankfully, his decision to see J. Martin Leland III, MD, sports medicine and orthopaedic surgeon at the University of Chicago Medicine, got him back on the field in relatively short order, after minimally invasive surgery to repair the damage from that great play.

Leland, who practices in Hyde Park and in Matteson, Ill., specializes in the joints that are most commonly injured in

sports — shoulders and knees.His first step was to recommend

physical therapy for Cavanaugh, who lives in Crown Point, Ind. �at helped the bone heal. �e next step was to fix the problems in the joint. Leland repaired the tissues using an arthroscope, a slim instrument inserted into the joint through a small incision.

Leland, who conducts ongoing research to find state-of-the-art treatments, is a sought-after educator and lecturer, offering his expertise to students, physicians and athletic trainers across Chicagoland.

His practice includes some of the most complex sports medicine surgeries,

Kenneth S. Polonsky, MD, is Dean of the Biological Sciences Division and the Pritzker School of Medicine, and executive vice president for Medical A�airs. He also is a leading diabetes researcher.

<conversation>with the Dean

>> What’s new at the University of Chicago Medicine?As we prepare for the opening of our new hospital in January 2013, we are transforming the patient experience to deliver compassionate, expert care with ease of access and state-of-the-art technology. It’s not only a magnificent facility, but a setting that provides support for our clinicians and staff to do their best work. And we have teams working on all the details of your visit, from additional parking we’re planning to new signage that will make it easy to get where you or your family need to be.

>> How does the new building re�ect the commitment to compassionate patient care?Many of our patients face complicated procedures and extended stays. �e new hospital will have private rooms spacious enough for family members to comfortably spend the night. And the nights can be tranquil and quiet, thanks to blackout shades and a state-of-the-art communications system that does not rely on overhead paging. �e building also will support very advanced technology for day-to-day care of patients with complex diseases.

>> What inspires you about the University of Chicago Medicine?Every day, I’m inspired by our brilliant, dedicated physi-

cians, researchers and care teams who collaborate to heal, to teach, to discover and to solve even the most difficult and challenging cases.

>> What makes you excited about the future?We are ideally positioned to be among the leaders in translational research, and therefore patient care, as we translate basic discoveries made in the laboratory into bedside care. �at means our patients often have access to innovative treatments before they are widely available.

>> Tell us about diabetes research at the University of Chicago Medicine.�e University of Chicago has a rich history of diabetes research dating back more than 100 years. Our ground-breaking work on the genetics of diabetes has received international recognition. We are at the forefront of customized diabetes diagnosis and treatment based on genetics, as well as research that may lead to novel therapies for this common disease.

To register for community events, please call 1-800-UCH-0200.

To view videos about orthopaedic injury prevention and treatment, please go to uchospitals.edu/specialties/ orthopaedic-surgery/video.html.

uchospitals.edu/physicians/j-martin-leland.html

twitter.com/DrMartinLeland

Getting Back in theGameOrthopaedic surgeon specializes in minimally invasive surgery for sports injuries

J. Martin Leland III, MD

Helping Your Fellow RatCalling someone a rat is no compliment. Maybe it should be. A team of University of Chicago neuroscientists found rats show empathy for

fellow rats in distress. In the study, published in Science, rats repeatedly acted to free fellow rats from a clear plastic tube. And

they were equally likely to free their cage mates as they were to nudge open a tube �lled with chocolate chips, a favorite treat. “This is the �rst evidence of helping behavior triggered by empathy in rats,” said Jean Decety, PhD.

Secrets to Living to 100People born in September, October or November have higher odds of cracking the century mark, a new study found. Seasonal di�erences in diet

and infection rates may be why. In past studies, researchers Leonid A. Gavrilov, PhD, and Natalia S. Gavrilova, PhD, of the University of Chicago’s Center on Aging, also found that chances for longevity are higher for people born to young mothers, those who have a slender or medium build at age 30 or who are farmers or spend their childhoods on a farm.

Time to Try Diet, Exercise FirstMiddle-aged adults recently diagnosed with diabetes and hypertension have time to learn how to control their high blood pressure without medication, but not too much time. The consequences of delaying e�ective hypertension treatment for up to a year were small — a two-day reduction in quality-adjusted life expectancy, University of Chicago Medicine researchers found. “Our results indicate that it’s OK to spend from six months

to a year, perhaps even longer, to make the di�cult lifestyle changes that are necessary and will pay o� in the long run,” said study author Neda Laiteerapong, MD.

Finding a Fin-Limb LinkUniversity of Chicago professor Neil Shubin’s 2004 discovery of the fossil Tiktaalik roseae made National Geographic’s list of 10 projects “that have made the greatest di�erence in understanding the Earth” — out of 10,000 projects the magazine has funded to date. Tiktaalik, which has �shlike features with limb joints, provided the missing link between �sh and the �rst animals that walked on land.

Read more at sciencelife.uchospitals.edu.


including multiligament knee reconstruc-tions and proximal hamstring repairs.

Leland’s experience and expertise also help patients quickly sort through the best treatment options — from the simple to the complex.

Whether your sport is downhill skiing, golf, volleyball or baseball, chances are you can’t escape a few aches and pains. Of course, not all injuries require surgery. A lot can heal through time and nonsurgical treatments.

“About 90 percent of my patients are nonoperative,” said Leland, former team physician for the Chicago Blackhawks. “My role is to help educate them on what’s going on in their body and how to continue being active without causing further damage.”

Nearly all of Leland’s surgeries are arthroscopic. �e small incisions signifi-cantly reduce pain and speed healing. Leland also works closely with physical therapists during rehabilitation. “I use very structured rehabilitation protocols and strength measurements to get patients to recover as quickly as possible,” he said.

Most patients can expect to return to full activities in anywhere from two weeks to six months, depending on the extent of the injury, Leland said.

As for Cavanaugh, he was happily back in center field just a few months after his surgery.

For survivors of lung cancer, even a lingering cough from a cold can be a worrisome sign. Robert Krull, 67, knows that fear all too well.

After surgeons at the University of Chicago Medicine removed cancer from Krull’s left lung in 2005, he gave up his

two-pack-a-day cigarette habit. But his emphy-sema, family history of lung cancer and the damage caused by 40 years of

smoking left the Long Beach, Ind., lawyer at risk for recurrence. Two years after the surgery, a CT scan revealed an ominous mass on Krull’s right lung. “I was terrified at first and then angry that the cancer had come back when I thought I’d done everything right with my treatment,” Krull said.

Krull’s pulmonologist, D. Kyle Hogarth, MD, also suspected cancer. But rather than have Krull undergo another extensive surgery to biopsy the mass, Hogarth, director of bronchoscopy and minimally invasive diagnostics at the University of Chicago Medicine, used a technology called electromagnetic navigation bronchoscopy to sample the abnormal tissue. Also known by its trade name, superDimension iLogic System, the high-tech device allows Hogarth to insert a scope through a patient’s mouth and maneuver it far into the lung to biopsy growths that previously required invasive measures to reach.

�e University of Chicago Medicine is a leader in electromagnetic navigation bronchoscopy in the Midwest, Hogarth said. In 2004, he was among the first

pulmonologists in Illinois to adopt superDimension.

A pioneer of several noninvasive technologies to prevent, detect and treat lung cancer, Hogarth wants to give individuals at risk for the disease a fighting chance. “More people die from lung cancer every year than from breast, colon and prostate cancers combined because lung cancer is typically diagnosed too late,” said Hogarth, who codirects a University of Chicago Medicine clinic for people at risk of lung cancer and other malignancies.

Hogarth leads a multidisciplinary team of specialists devoted to finding and treating lung cancer at its earliest stages, as well as reducing individuals’ risks of getting cancer. “We want the same early detection and vastly improved outcomes for patients with lung cancer that survivors of breast and colon cancers get from mammography and colonoscopy,” Hogarth said.

Reaching lesions deep in the lungUntil recently, the lungs’ complex and narrow branching system has made minimally invasive diagnosis and treatment of early-stage lung cancer challenging. More than 70 percent of cancerous lesions start in areas that are outside the direct view of a broncho-scope, a tube with a light and a camera that can inspect the airways for abnor-malities and biopsy them. “I can go into the first and second branches of the upper lobe of the lung with conventional bronchoscopy, but then the airways narrow as they continue branching,” Hogarth said. Sometimes a biopsy is obtained by sticking a needle through the chest wall into the lung.

GPSfor your lungsNew technology allows doctors to reach deep into the lungs to diagnose lesions without a scalpel

Cancer Centers

Robert Krull, left, and D. Kyle Hogarth, MD

Leading the Fight Against Cancer

Ranked #1 in Illinois and #14 in nation by U.S. News & World ReportMore than 350 cancer clinical trials

210 University of Chicago laboratory and clinical scientists focusing their efforts on cancer

1 of only a few programs nationwide with NCI-sponsored Phase I, Phase II and Phase III clinical trials of anticancer drugs or procedures

Highest overall rating from the American College of Surgeons Commission on Cancer uchospitals.edu/cancer

continued on page 9

The University of Chicago Medicine’s leading-edge

cancer care is available at multiple locations

throughout Chicagoland.

New center at Silver CrossThe University of Chicago

Medicine Comprehensive Cancer Center at Silver Cross Hospital

opens by summer in New Lenox, Ill. The new

$21.6 million, 20,000-square-foot outpatient cancer center, a joint venture between the University of Chicago Medicine and Silver

Cross Hospital, will provide state-of-the-art chemotherapy and radiation therapy, as well

as access to innovative clinical trials not usually found in a

community setting. Patients can receive comprehensive cancer care for adult, gynecologic and

pediatric cancers.

Schererville, Ind.Gynecologic oncology cancer

care is offered at the University of Chicago Health Specialists

in Schererville, Ind.

Naperville — Palos Heights — Merrillville, Ind.

Compassionate and personalized pediatric cancer

care from University of Chicago Medicine children’s

cancer specialists is available at offices at Edward Hospital

in Naperville, Ill., and in Palos Heights, Ill., and

Merrillville, Ind.

ElginUniversity of Chicago Medicine

physicians provide radiation oncology services

at Sherman Hospital’s Cancer Care Center in Elgin, Ill.

AT THE FOREFRONT

�e University of Chicago Medicine’s pulmonology program is ranked #1 in the state by U.S. News &World Report.



For survivors of lung cancer, even a lingering cough from a cold can be a worrisome sign. Robert Krull, 67, knows that fear all too well.

After surgeons at the University of Chicago Medicine removed cancer from Krull’s left lung in 2005, he gave up his

two-pack-a-day cigarette habit. But his emphy-sema, family history of lung cancer and the damage caused by 40 years of

smoking left the Long Beach, Ind., lawyer at risk for recurrence. Two years after the surgery, a CT scan revealed an ominous mass on Krull’s right lung. “I was terrified at first and then angry that the cancer had come back when I thought I’d done everything right with my treatment,” Krull said.

Krull’s pulmonologist, D. Kyle Hogarth, MD, also suspected cancer. But rather than have Krull undergo another extensive surgery to biopsy the mass, Hogarth, director of bronchoscopy and minimally invasive diagnostics at the University of Chicago Medicine, used a technology called electromagnetic navigation bronchoscopy to sample the abnormal tissue. Also known by its trade name, superDimension iLogic System, the high-tech device allows Hogarth to insert a scope through a patient’s mouth and maneuver it far into the lung to biopsy growths that previously required invasive measures to reach.

�e University of Chicago Medicine is a leader in electromagnetic navigation bronchoscopy in the Midwest, Hogarth said. In 2004, he was among the first

pulmonologists in Illinois to adopt superDimension.

A pioneer of several noninvasive technologies to prevent, detect and treat lung cancer, Hogarth wants to give individuals at risk for the disease a fighting chance. “More people die from lung cancer every year than from breast, colon and prostate cancers combined because lung cancer is typically diagnosed too late,” said Hogarth, who codirects a University of Chicago Medicine clinic for people at risk of lung cancer and other malignancies.

Hogarth leads a multidisciplinary team of specialists devoted to finding and treating lung cancer at its earliest stages, as well as reducing individuals’ risks of getting cancer. “We want the same early detection and vastly improved outcomes for patients with lung cancer that survivors of breast and colon cancers get from mammography and colonoscopy,” Hogarth said.

Reaching lesions deep in the lungUntil recently, the lungs’ complex and narrow branching system has made minimally invasive diagnosis and treatment of early-stage lung cancer challenging. More than 70 percent of cancerous lesions start in areas that are outside the direct view of a broncho-scope, a tube with a light and a camera that can inspect the airways for abnor-malities and biopsy them. “I can go into the first and second branches of the upper lobe of the lung with conventional bronchoscopy, but then the airways narrow as they continue branching,” Hogarth said. Sometimes a biopsy is obtained by sticking a needle through the chest wall into the lung.

GPSfor your lungsNew technology allows doctors to reach deep into the lungs to diagnose lesions without a scalpel

Cancer Centers

Robert Krull, left, and D. Kyle Hogarth, MD

Leading the Fight Against Cancer

Ranked #1 in Illinois and #14 in nation by U.S. News & World ReportMore than 350 cancer clinical trials

210 University of Chicago laboratory and clinical scientists focusing their efforts on cancer

1 of only a few programs nationwide with NCI-sponsored Phase I, Phase II and Phase III clinical trials of anticancer drugs or procedures

Highest overall rating from the American College of Surgeons Commission on Cancer uchospitals.edu/cancer

continued on page 9

The University of Chicago Medicine’s leading-edge

cancer care is available at multiple locations

throughout Chicagoland.

New center at Silver CrossThe University of Chicago

Medicine Comprehensive Cancer Center at Silver Cross Hospital

opens by summer in New Lenox, Ill. The new

$21.6 million, 20,000-square-foot outpatient cancer center, a joint venture between the University of Chicago Medicine and Silver

Cross Hospital, will provide state-of-the-art chemotherapy and radiation therapy, as well

as access to innovative clinical trials not usually found in a

community setting. Patients can receive comprehensive cancer care for adult, gynecologic and

pediatric cancers.

Schererville, Ind.Gynecologic oncology cancer

care is offered at the University of Chicago Health Specialists

in Schererville, Ind.

Naperville — Palos Heights — Merrillville, Ind.

Compassionate and personalized pediatric cancer

care from University of Chicago Medicine children’s

cancer specialists is available at offices at Edward Hospital

in Naperville, Ill., and in Palos Heights, Ill., and

Merrillville, Ind.

ElginUniversity of Chicago Medicine

physicians provide radiation oncology services

at Sherman Hospital’s Cancer Care Center in Elgin, Ill.

AT THE FOREFRONT

�e University of Chicago Medicine’s pulmonology program is ranked #1 in the state by U.S. News &World Report.



On Christmas Eve 2009, Glenn Bovard and his wife were celebrating near their home in Valparaiso, Ind., when Bovard suffered a massive heart attack.

Bovard, 64, is a resilient sort. In 1968, the truck he was driving in Vietnam hit a land mine. �e explosion killed seven fellow U.S. soldiers. Bovard sustained widespread burns. In 1974, he began a 33-year career with the Indiana State Police.

But this was the closest call yet for the retired trooper. He was rushed to nearby Porter Hospital, then transferred to the University of Chicago Medicine, where

Valluvan Jeevanandam, MD, chief of cardiac and thoracic surgery, performed emergency surgery to

implant a ventricular assist device (VAD) into his failing heart.

�e HeartMate® II consists of a tube

that runs between the heart’s left ventricle — the pumping capacity of which often is impaired in heart failure patients — and the aorta, from which blood is circulated around the body. Inside the tube, a rotor boosts the patient’s blood flow. �e device is connected via a “driveline” that goes through the skin to a control unit that sits like a fanny pack on the patient’s waist. It is powered by two batteries secured under the patient’s arms. To stow the gear, which weighs around 7 pounds, Bovard bought two photographer’s jackets.

�e device offers a stopgap for patients awaiting transplantation. It also is a permanent therapy that some patients can live with for years.

University of Chicago Medicine physicians implanted 58 VADs in 2011, among the highest number at any U.S. institution.

�e burgeoning VAD program complements the University of Chicago Medicine’s long-standing leadership in heart transplantation. Jeevanandam alone has performed approximately 1,200

transplants. And under his aegis, the University of Chicago Medicine has helped pioneer “total transplant,” whereby — when possible — all of the diseased heart is removed and the full donor heart is implanted. �is promotes improved heart performance and fewer complications compared to the standard procedure, in which the new heart is grafted onto parts of the diseased heart that are left intact.

VADs and transplants take their place within a panoply of therapies for advanced congestive heart failure at the University of Chicago Medicine. Physi-cians credit the broad range of treatment options to a team approach to care and close collaboration between medicine and surgery.

Indeed, Jeevanandam and his colleagues work tirelessly to prevent patients from needing a VAD or transplant in the first place.

“With medical intervention, we often can prevent patients from needing those advanced therapies,” said Allen S. Anderson, MD, director of the Advanced Heart Failure Program.

Surgically, the first step often is to try to repair or reconstruct the patient’s heart. “We don’t rush to the easiest therapy,” Jeevanandam said. “Doing a transplant or putting in a VAD can often be easier than reconstructing a heart, but preserving a patient’s own heart is almost always preferable, if possible.”

After decades of patching up Walter Zimmerman’s heart, doctors near his home in Cary, Ill., had reached the limits of what they could do for the retired plastics industry sales executive. Zimmer-man was referred to the University of Chicago Medicine, where he received a VAD in November 2010.

Beforehand, “my son came to me with tears in his eyes,” recalled Zimmerman, 73. “He said, ‘You don’t have to do this. You’ve been through an awful lot.’”

“I said, ‘I’ve got to do it for you guys.’ ‘No, do it for yourself,’ he replied. ‘No difference,’ I said.”

Zimmerman was back on his feet soon after VAD surgery.

While Bovard, too, was happy with his VAD, it was determined that his next step, after his body recovered, would be a heart transplant. After consulting with Jeevanandam, he decided to proceed.

He still chokes up recalling coming around following his transplant, last June. “I could feel the heart beat; it was amazing.”

Today, Bovard wears a mask to safeguard against germs when he’s out, but he drives, does household chores and even has taken in a show in Chicago. �e regimen of pills he must take daily to prevent his body from rejecting the organ is down from 32 to between 18 and 20.

“�ings are good and getting better,” he said.

Glenn Bovard

In other cases, surgery is required to obtain a tissue sample.

But superDimension’s navigation catheters allow Hogarth to safely maneuver a bronchoscope virtually anywhere in the lung. After receiving anesthesia for the outpatient procedure, Krull was positioned on an electromagnetic panel that functions as a sort of GPS, guiding the sensor-equipped scope toward the lesion. Hogarth tracked the scope’s exact location on a three-dimensional road map of Krull’s lungs projected on a plasma screen.

Even patients with the most challenging lung problems — advanced emphysema, those with only one lung or with severe heart disease — can have suspicious growths biopsied with superDimension. �is technology will reduce the number of undiagnosed lesions, Hogarth said.

If lung cancer is found, superDi-mension also can improve treatment. Hogarth uses the navigational scope, for example, to implant tiny metal tags around a tumor, allowing radiation oncologists to more precisely and safely aim the beam at only the cancerous tissue.

When Krull woke from the 30-minute superDimension proce-dure, he found Hogarth grinning at him. Instead of cancer, Hogarth found what appeared to be a fungal infection in Krull’s lung, which was confirmed by a pathologist. “I was elated,” said Krull, who played golf the next day.

Finding cancer earlyAs of his last visit, Krull is cancer-free. Hogarth wants to increase the

chances of keeping him that way by checking his lungs annually for tiny lung cancers and premalignant lesions. �ese growths distort the tissues around them and make the airway thicker, changes that are invisible on a CT scan. �e Univer-sity of Chicago Medicine is one of

the only hospitals in the Midwest that offers autofluorescence bronchoscopy to screen for precan-cerous changes in cells in individuals at risk for developing lung cancer.

Autofluorescence bronchoscopy causes abnormal tissue to glow a different color than healthy tissue and “more than doubles the number of premalignant lesions we can detect,” Hogarth said. “Like a polyp in the colon, we can laser it out while we’re in there and potentially prevent cancer from developing.”

Seven years after being treated for lung cancer, Krull says he feels and looks healthier than he has in a long time. “Friends mention that I don’t have a gray pallor since I stopped smoking, and I’m not afraid to buy green bananas,” Krull joked.

And for Hogarth, there is no greater gratification than knowing that the more than 700 bronchosco-pies he performs each year are “quite literally, helping to nip lung cancer in the bud.”


uchospitals.edu/physicians/d-kyle-hogarth.html

Collaboratingto �x a broken heart

Team offers hope to patients with advanced heart failure

Allen S. Anderson, MD, left, and Valluvan Jeevanandam, MD

AT THE FOREFRONT

Four of the 11 heart-liver-kidneytransplants performed in the U.S.

were done at theUniversity of Chicago Medicine.

“�is technology more than doubles the number of premalignant lesions we can detect.”D. KYLE HOGARTH, MD

CONTINUED FROM PAGE 7

Multidisciplinary team strives to improve lung cancer outcomes

GPSfor your lungs

Zimmerman, too, is living life to the fullest, having been able to continue with the VAD rather than having a transplant.

�e physical encumbrance is “a small price to pay,” he said, for precious moments with his family.

He has flown to California to see his grandchildren and doesn’t let the VAD cramp his style on the golf course, tying the batteries behind him so he can drive the ball.

One thing Zimmerman can’t do anything about is his short game. But after he groused about it, the club pro couldn’t resist. “Well, you never could putt or chip,” he shot back.uchospitals.edu/specialties/heart/services/heart-failure

On Christmas Eve 2009, Glenn Bovard and his wife were celebrating near their home in Valparaiso, Ind., when Bovard suffered a massive heart attack.

Bovard, 64, is a resilient sort. In 1968, the truck he was driving in Vietnam hit a land mine. �e explosion killed seven fellow U.S. soldiers. Bovard sustained widespread burns. In 1974, he began a 33-year career with the Indiana State Police.

But this was the closest call yet for the retired trooper. He was rushed to nearby Porter Hospital, then transferred to the University of Chicago Medicine, where

Valluvan Jeevanandam, MD, chief of cardiac and thoracic surgery, performed emergency surgery to

implant a ventricular assist device (VAD) into his failing heart.

�e HeartMate® II consists of a tube

that runs between the heart’s left ventricle — the pumping capacity of which often is impaired in heart failure patients — and the aorta, from which blood is circulated around the body. Inside the tube, a rotor boosts the patient’s blood flow. �e device is connected via a “driveline” that goes through the skin to a control unit that sits like a fanny pack on the patient’s waist. It is powered by two batteries secured under the patient’s arms. To stow the gear, which weighs around 7 pounds, Bovard bought two photographer’s jackets.

�e device offers a stopgap for patients awaiting transplantation. It also is a permanent therapy that some patients can live with for years.

University of Chicago Medicine physicians implanted 58 VADs in 2011, among the highest number at any U.S. institution.

�e burgeoning VAD program complements the University of Chicago Medicine’s long-standing leadership in heart transplantation. Jeevanandam alone has performed approximately 1,200

transplants. And under his aegis, the University of Chicago Medicine has helped pioneer “total transplant,” whereby — when possible — all of the diseased heart is removed and the full donor heart is implanted. �is promotes improved heart performance and fewer complications compared to the standard procedure, in which the new heart is grafted onto parts of the diseased heart that are left intact.

VADs and transplants take their place within a panoply of therapies for advanced congestive heart failure at the University of Chicago Medicine. Physi-cians credit the broad range of treatment options to a team approach to care and close collaboration between medicine and surgery.

Indeed, Jeevanandam and his colleagues work tirelessly to prevent patients from needing a VAD or transplant in the first place.

“With medical intervention, we often can prevent patients from needing those advanced therapies,” said Allen S. Anderson, MD, director of the Advanced Heart Failure Program.

Surgically, the first step often is to try to repair or reconstruct the patient’s heart. “We don’t rush to the easiest therapy,” Jeevanandam said. “Doing a transplant or putting in a VAD can often be easier than reconstructing a heart, but preserving a patient’s own heart is almost always preferable, if possible.”

After decades of patching up Walter Zimmerman’s heart, doctors near his home in Cary, Ill., had reached the limits of what they could do for the retired plastics industry sales executive. Zimmer-man was referred to the University of Chicago Medicine, where he received a VAD in November 2010.

Beforehand, “my son came to me with tears in his eyes,” recalled Zimmerman, 73. “He said, ‘You don’t have to do this. You’ve been through an awful lot.’”

“I said, ‘I’ve got to do it for you guys.’ ‘No, do it for yourself,’ he replied. ‘No difference,’ I said.”

Zimmerman was back on his feet soon after VAD surgery.

While Bovard, too, was happy with his VAD, it was determined that his next step, after his body recovered, would be a heart transplant. After consulting with Jeevanandam, he decided to proceed.

He still chokes up recalling coming around following his transplant, last June. “I could feel the heart beat; it was amazing.”

Today, Bovard wears a mask to safeguard against germs when he’s out, but he drives, does household chores and even has taken in a show in Chicago. �e regimen of pills he must take daily to prevent his body from rejecting the organ is down from 32 to between 18 and 20.

“�ings are good and getting better,” he said.

Glenn Bovard

In other cases, surgery is required to obtain a tissue sample.

But superDimension’s navigation catheters allow Hogarth to safely maneuver a bronchoscope virtually anywhere in the lung. After receiving anesthesia for the outpatient procedure, Krull was positioned on an electromagnetic panel that functions as a sort of GPS, guiding the sensor-equipped scope toward the lesion. Hogarth tracked the scope’s exact location on a three-dimensional road map of Krull’s lungs projected on a plasma screen.

Even patients with the most challenging lung problems — advanced emphysema, those with only one lung or with severe heart disease — can have suspicious growths biopsied with superDimension. �is technology will reduce the number of undiagnosed lesions, Hogarth said.

If lung cancer is found, superDi-mension also can improve treatment. Hogarth uses the navigational scope, for example, to implant tiny metal tags around a tumor, allowing radiation oncologists to more precisely and safely aim the beam at only the cancerous tissue.

When Krull woke from the 30-minute superDimension proce-dure, he found Hogarth grinning at him. Instead of cancer, Hogarth found what appeared to be a fungal infection in Krull’s lung, which was confirmed by a pathologist. “I was elated,” said Krull, who played golf the next day.

Finding cancer earlyAs of his last visit, Krull is cancer-free. Hogarth wants to increase the

chances of keeping him that way by checking his lungs annually for tiny lung cancers and premalignant lesions. �ese growths distort the tissues around them and make the airway thicker, changes that are invisible on a CT scan. �e Univer-sity of Chicago Medicine is one of

the only hospitals in the Midwest that offers autofluorescence bronchoscopy to screen for precan-cerous changes in cells in individuals at risk for developing lung cancer.

Autofluorescence bronchoscopy causes abnormal tissue to glow a different color than healthy tissue and “more than doubles the number of premalignant lesions we can detect,” Hogarth said. “Like a polyp in the colon, we can laser it out while we’re in there and potentially prevent cancer from developing.”

Seven years after being treated for lung cancer, Krull says he feels and looks healthier than he has in a long time. “Friends mention that I don’t have a gray pallor since I stopped smoking, and I’m not afraid to buy green bananas,” Krull joked.

And for Hogarth, there is no greater gratification than knowing that the more than 700 bronchosco-pies he performs each year are “quite literally, helping to nip lung cancer in the bud.”


uchospitals.edu/physicians/d-kyle-hogarth.html

Collaboratingto �x a broken heart

Team offers hope to patients with advanced heart failure

Allen S. Anderson, MD, left, and Valluvan Jeevanandam, MD

AT THE FOREFRONT

Four of the 11 heart-liver-kidneytransplants performed in the U.S.

were done at theUniversity of Chicago Medicine.

“�is technology more than doubles the number of premalignant lesions we can detect.”D. KYLE HOGARTH, MD

CONTINUED FROM PAGE 7

Multidisciplinary team strives to improve lung cancer outcomes

GPSfor your lungs

Zimmerman, too, is living life to the fullest, having been able to continue with the VAD rather than having a transplant.

�e physical encumbrance is “a small price to pay,” he said, for precious moments with his family.

He has flown to California to see his grandchildren and doesn’t let the VAD cramp his style on the golf course, tying the batteries behind him so he can drive the ball.

One thing Zimmerman can’t do anything about is his short game. But after he groused about it, the club pro couldn’t resist. “Well, you never could putt or chip,” he shot back.uchospitals.edu/specialties/heart/services/heart-failure

getting kids to sleepOur children’s sleep specialists offer

innovative, state-of-the-art care, including a new home sleep studies program

Improving Pacemaker SafetyCardiologist develops mathematical model to

reduce the risk from heart-device wires

University of Chicago Medicine children’s sleep specialists are pioneering a new program to make the diagnosis of sleep apnea easier on kids and more affordable for parents. Instead of spend-ing the night in a sleep laboratory, your child can be monitored in the comfort of his own bed.

�e simple, lightweight device uses wireless technology, which makes it easy for parents to put it on and take it off their child. Data from the home sleep study is transmitted to University of Chicago Medicine board-certified pediatric sleep specialists for interpreta-tion. If treatment is needed, our sleep specialists can work with your child’s primary physician to suggest the best course for follow-up care.

“We want to offer families a test that is simple, not costly, that can be done at home and that will allow us to provide answers to their children’s sleep problems quickly,” said Hari Bandla, MD, chief of pediatric sleep medicine.

Meanwhile, Gozal is leading a research team working on developing an even simpler test. �eir work on a urine test to diagnose sleep apnea in children is supported by a grant from the National Institutes of Health.

University of Chicago Medicine scientists also are aggressively exploring new treatments, including drugs aimed at making the standard treatment for sleep apnea — removal of the tonsils and adenoids — more successful. �ese new

treatments might even allow some children to avoid surgery.

Snoring is the primary symptom of obstructive sleep apnea, but only about 20 percent of children who snore have the disorder. �e others may be simple snorers with stuffy noses or allergies. Regardless, snoring in children should not be taken lightly.

“No child should snore,” Bandla said. “�at is the message.”

In most cases, the home sleep study will provide enough data to tell if a child’s snoring is caused by apnea. Children with

AT THE FOREFRONT

University of Chicago sleepscientists discovered rapid eye

movement (REM) sleepin 1953.

To find out if a home sleep study is right for your child, please call 1-888-UCH-0200. Visit uchicagokidshospital.org/home-sleep to learn more.

Martin C. Burke, DO


All too often, the sweet dreams of childhood are just a myth.Some children snore like little buzz saws. Others struggle to sleep at night, which makes them

cranky all day.Expert diagnosis and treatment from the pediatric sleep specialists at the University of Chicago

Medicine can help get children — and their weary parents — back on track to restful sleep.“A sleepless child is not the only one who is sleepless in the house,” said David Gozal, MD,

chair of pediatrics and one of the world’s foremost experts on children’s sleep disorders.Along with providing comprehensive care for children with sleep disorders, physician-scientists

and researchers at Comer Children’s Hospital at the University of Chicago Medicine are studying why sleep disorders occur and the best ways to treat them. �at gives families access to innovative, state-of-the-art treatments often not available elsewhere.

“We have extensive expertise, and we can offer a variety of diagnostic tools and treatments, many of which were developed here,” Gozal said.

Sleep disorders are surprisingly common in kids, and can cause behavior, learning and health problems. Fifteen percent of preschoolers suffer from insomnia. Up to 4 percent have sleep apnea, an obstruction of the air passages that disrupts normal sleep patterns. For children with obesity, the rate is as high as 10 percent.

more complex sleep problems may need a more comprehensive overnight study in a hospital or clinic. Our children’s sleep specialists have the ability to analyze data from sleep studies that are conducted at the University of Chicago Medicine main campus in Hyde Park, the Institute of Sleep Medicine of DuPage Medical Group in Naperville, Ill., and Adventist Hinsdale Hospital in Hinsdale, Ill. Out- patient care by our pediatric sleep medicine specialists is available on the main campus and at our clinics in Westmont, Ill., Naperville, Ill., and Merrillville, Ind.

“We understand parents have busy schedules,” Gozal said. �at’s why our sleep medicine specialists work hard to minimize the number of return visits a family has to make, to streamline treatment plans and to work in collaboration with the child’s pediatrician, he said.

For the most challenging cases, a multidisciplinary University of Chicago Medicine team may include a sleep specialist, ear, nose, and throat surgeon, craniofacial surgeon and orthodontist working together to treat the child. Behavioral therapy also is offered to families who need help establishing healthier daytime and nighttime routines.

Our sleep experts also diagnose and treat many other disorders that disrupt kids’ sleep. �ese include bed-wetting, narcolepsy, parasomnias, period limb movement disorder, restless leg syndrome, sleepwalking, trouble falling asleep or awakening and teen sleep problems.

It’s important to nip children’s sleep disorders in the bud, because they can have serious consequences. Kids who don’t get enough sleep may be crabby at home and struggle in school. �eir parents are almost certainly frazzled.

In a recent study, Gozal measured the sleep of more than 300 children ages 4 to 10. He found that children with disturbed sleep have a risk of obesity that’s up to four times higher than kids who get enough sleep. Long-term disrupted sleep is linked to obesity, diabetes and altered cardiovascular function in adults.

“Our mandate is not only to make sure children are healthy, but to make sure they become healthy adults,” Gozal said.

Pacemakers and implantable cardioverter-de�brillators (ICDs) can be lifesavers. But sometimes the “wiring” that connects them to the heart needs to be removed to treat dangerous infections and other complications, such as when a wire in the heart fails to function normally.

Making sure your physician knows when to remove these “leads” when there is an infection or before they fail is key.

Researchers at the University of Chicago Medicine have developed a mathematical tool to help physicians do just that. Now they are turning it into a mobile app that physicians will be able to use when patients come in to have the battery on their pacemaker or ICD replaced.

The tool was developed by a team of physicians led by Martin C. Burke, DO, interim chief of cardiology and director of the Heart Rhythm Center, who presented their �ndings at the recent American Heart Association meeting in Orlando, Fla.

By helping predict lead problems before they occur, the tool may allow more patients to bene�t from these heart devices, Burke said.

“Approximately 60 percent of patients who are currently eligible to receive an ICD don’t get this therapy,” Burke said. “A major reason is the perceived risk of wire complications.”

This includes many younger patients, such as those in their 50s, who delay getting an ICD because of concerns about what will happen to the leads over time.

“With this model, patients and their doctors will feel more comfortable knowing that we are able to address problems before they happen,” Burke said. “Knowing when to extract or not based on safety to the patient is the most attractive piece of this research.”

When leads have problems, University of Chicago Medicine physicians can remove them using state-of-the-art laser techniques. Due to their extensive expertise, University of Chicago Medicine heart rhythm physicians were the �rst in the country to test a promising new type of ICD that does not use leads in the heart.uchospitals.edu/physicians/martin-burke.html

getting kids to sleepOur children’s sleep specialists offer

innovative, state-of-the-art care, including a new home sleep studies program

Improving Pacemaker SafetyCardiologist develops mathematical model to

reduce the risk from heart-device wires

University of Chicago Medicine children’s sleep specialists are pioneering a new program to make the diagnosis of sleep apnea easier on kids and more affordable for parents. Instead of spend-ing the night in a sleep laboratory, your child can be monitored in the comfort of his own bed.

�e simple, lightweight device uses wireless technology, which makes it easy for parents to put it on and take it off their child. Data from the home sleep study is transmitted to University of Chicago Medicine board-certified pediatric sleep specialists for interpreta-tion. If treatment is needed, our sleep specialists can work with your child’s primary physician to suggest the best course for follow-up care.

“We want to offer families a test that is simple, not costly, that can be done at home and that will allow us to provide answers to their children’s sleep problems quickly,” said Hari Bandla, MD, chief of pediatric sleep medicine.

Meanwhile, Gozal is leading a research team working on developing an even simpler test. �eir work on a urine test to diagnose sleep apnea in children is supported by a grant from the National Institutes of Health.

University of Chicago Medicine scientists also are aggressively exploring new treatments, including drugs aimed at making the standard treatment for sleep apnea — removal of the tonsils and adenoids — more successful. �ese new

treatments might even allow some children to avoid surgery.

Snoring is the primary symptom of obstructive sleep apnea, but only about 20 percent of children who snore have the disorder. �e others may be simple snorers with stuffy noses or allergies. Regardless, snoring in children should not be taken lightly.

“No child should snore,” Bandla said. “�at is the message.”

In most cases, the home sleep study will provide enough data to tell if a child’s snoring is caused by apnea. Children with

AT THE FOREFRONT

University of Chicago sleepscientists discovered rapid eye

movement (REM) sleepin 1953.

To find out if a home sleep study is right for your child, please call 1-888-UCH-0200. Visit uchicagokidshospital.org/home-sleep to learn more.

Martin C. Burke, DO


All too often, the sweet dreams of childhood are just a myth.Some children snore like little buzz saws. Others struggle to sleep at night, which makes them

cranky all day.Expert diagnosis and treatment from the pediatric sleep specialists at the University of Chicago

Medicine can help get children — and their weary parents — back on track to restful sleep.“A sleepless child is not the only one who is sleepless in the house,” said David Gozal, MD,

chair of pediatrics and one of the world’s foremost experts on children’s sleep disorders.Along with providing comprehensive care for children with sleep disorders, physician-scientists

and researchers at Comer Children’s Hospital at the University of Chicago Medicine are studying why sleep disorders occur and the best ways to treat them. �at gives families access to innovative, state-of-the-art treatments often not available elsewhere.

“We have extensive expertise, and we can offer a variety of diagnostic tools and treatments, many of which were developed here,” Gozal said.

Sleep disorders are surprisingly common in kids, and can cause behavior, learning and health problems. Fifteen percent of preschoolers suffer from insomnia. Up to 4 percent have sleep apnea, an obstruction of the air passages that disrupts normal sleep patterns. For children with obesity, the rate is as high as 10 percent.

more complex sleep problems may need a more comprehensive overnight study in a hospital or clinic. Our children’s sleep specialists have the ability to analyze data from sleep studies that are conducted at the University of Chicago Medicine main campus in Hyde Park, the Institute of Sleep Medicine of DuPage Medical Group in Naperville, Ill., and Adventist Hinsdale Hospital in Hinsdale, Ill. Out- patient care by our pediatric sleep medicine specialists is available on the main campus and at our clinics in Westmont, Ill., Naperville, Ill., and Merrillville, Ind.

“We understand parents have busy schedules,” Gozal said. �at’s why our sleep medicine specialists work hard to minimize the number of return visits a family has to make, to streamline treatment plans and to work in collaboration with the child’s pediatrician, he said.

For the most challenging cases, a multidisciplinary University of Chicago Medicine team may include a sleep specialist, ear, nose, and throat surgeon, craniofacial surgeon and orthodontist working together to treat the child. Behavioral therapy also is offered to families who need help establishing healthier daytime and nighttime routines.

Our sleep experts also diagnose and treat many other disorders that disrupt kids’ sleep. �ese include bed-wetting, narcolepsy, parasomnias, period limb movement disorder, restless leg syndrome, sleepwalking, trouble falling asleep or awakening and teen sleep problems.

It’s important to nip children’s sleep disorders in the bud, because they can have serious consequences. Kids who don’t get enough sleep may be crabby at home and struggle in school. �eir parents are almost certainly frazzled.

In a recent study, Gozal measured the sleep of more than 300 children ages 4 to 10. He found that children with disturbed sleep have a risk of obesity that’s up to four times higher than kids who get enough sleep. Long-term disrupted sleep is linked to obesity, diabetes and altered cardiovascular function in adults.

“Our mandate is not only to make sure children are healthy, but to make sure they become healthy adults,” Gozal said.

Pacemakers and implantable cardioverter-de�brillators (ICDs) can be lifesavers. But sometimes the “wiring” that connects them to the heart needs to be removed to treat dangerous infections and other complications, such as when a wire in the heart fails to function normally.

Making sure your physician knows when to remove these “leads” when there is an infection or before they fail is key.

Researchers at the University of Chicago Medicine have developed a mathematical tool to help physicians do just that. Now they are turning it into a mobile app that physicians will be able to use when patients come in to have the battery on their pacemaker or ICD replaced.

The tool was developed by a team of physicians led by Martin C. Burke, DO, interim chief of cardiology and director of the Heart Rhythm Center, who presented their �ndings at the recent American Heart Association meeting in Orlando, Fla.

By helping predict lead problems before they occur, the tool may allow more patients to bene�t from these heart devices, Burke said.

“Approximately 60 percent of patients who are currently eligible to receive an ICD don’t get this therapy,” Burke said. “A major reason is the perceived risk of wire complications.”

This includes many younger patients, such as those in their 50s, who delay getting an ICD because of concerns about what will happen to the leads over time.

“With this model, patients and their doctors will feel more comfortable knowing that we are able to address problems before they happen,” Burke said. “Knowing when to extract or not based on safety to the patient is the most attractive piece of this research.”

When leads have problems, University of Chicago Medicine physicians can remove them using state-of-the-art laser techniques. Due to their extensive expertise, University of Chicago Medicine heart rhythm physicians were the �rst in the country to test a promising new type of ICD that does not use leads in the heart.uchospitals.edu/physicians/martin-burke.html

Brain cancer is among the most

difficult malignancies to treat. Physician-scientists at the University of Chicago Medicine are researching innovative ways to make treatment easier.

Maciej S. Lesniak, MD, director of neuro-oncology research at the University of Chicago Medicine, is collaborating with scientists at the University of Chicago’s Center for Nanoscale Materials and the Materials Science Division at Argonne National Laboratory on a novel therapy that uses magnetic nanoparticles to destroy cancer cells.

And Bakhtiar Yamini, MD, assistant professor of surgery at the University of Chicago Medicine, collaborated with a Nebraska biotechnology company to design a nanoparticle “shell” capable of selectively targeting therapeutics to brain tumor cells.

Lesniak recently was awarded a five-year, $3 million grant from the National Institutes of Health to begin testing the nanomagnetic therapy in animal models.

“�ere have been advances in therapy for brain cancer, but they haven’t been significant enough to make a tremendous difference in terms of extending life,” Lesniak said.

Lesniak and his team are at the forefront of research with a total of $13 million in NIH grants to study brain tumor treatments, including gene therapy, immunotherapy and neural stem cells.

�e nanomedicine technique developed by the University of Chicago Medicine and Argonne scientists uses magnetic

A doctor-patient relationshipinspired one of the largest donations

ever pledged to theUniversity of Chicago Medicine.

University of Chicago studies conducted in two Chicago suburbs

lead to the �uoridation of water — and fewer cavities — nationwide.

World’s �rst successful living-donor liver transplant.

First successful heart-liver-kidney transplant.

Bruce A. Beutler, MD, a 1981 graduate of the Pritzker School of Medicine, wins the Nobel Prize, becoming one of 87 Nobel laureates associated with the University of Chicago.

1972 20111946-61 1989

1999A cardiac surgeon performs the �rst heart transplant, on a dog.

Early1900s

The Matthew and Carolyn Bucksbaum Family Foundation is giving $42 million to the University of Chicago to create a unique program to improve doctor-patient communication.

The Bucksbaums’ longtime physician, Mark Siegler, MD, will lead the initiative.

“Our doctor, Mark Siegler, showed us what good doctoring involved, and it was just as much about compassion and communication as his outstanding clinical competence,” Carolyn “Kay” Bucksbaum said.

“In Dr. Siegler, I have had a doctor who is interested in my husband and me as persons, not just diseases, although we’ve confronted him with a few of them. I have so valued that. A special mark of Dr. Siegler’s character is his extreme kindness and interest in what makes us tick.”

The Bucksbaum Institute for Clinical Excellence will train medical students, junior faculty members and senior clinicians to serve as role models and mentors in communication and shared decision making.

According to a 2001 study by the Commonwealth Fund, one in �ve U.S. adults had trouble communicat-ing with doctors and one in 10 felt they had been treated disrespectfully during a recent health care visit.

Kay Bucksbaum hopes the Bucksbaum Institute will address this problem by becoming a clinical and teaching model nationwide, emulated by other academic medical centers.

“This is a transformative gift, the kind that has an impact sustained over generations,” said Holly J. Humphrey, MD, dean for medical education at the University of Chicago Pritzker School of Medicine.

Eye

sw

ide

open

Patient awake, talking as surgeon removeslemon-size tumor from her brain

�e next big thing in brain cancer treatment might be very, very small

Anna Litchfield and Maciej S. Lesniak, MD

Surgery can be a daunting experience for anyone, though thanks to general anesthesia, it’s not typically a memorable one. �at’s not so for patients who go through an awake craniotomy — a unique procedure that allows surgeons to react based on feedback from the patient during removal of a brain tumor.

“I remember them waking me up, using a flashlight and talking to me,” said Anna Litchfield, 50, who was operated on in August by Maciej S. Lesniak, MD, director of neurosurgical oncology at the

University of Chicago Medicine. “I remember Dr. Lesniak saying, ‘Anna, are you OK?’ and I remember saying, ‘Great, Dr. L!’”

Awake craniotomies typically are used to remove tumors nestled close to functional areas of the brain. As the surgeon carefully removes the tumor, a neurologist monitors the patient to minimize damage to critical parts of the brain.

“When tumors are in what we call eloquent, functional areas, the margin of error is a millimeter,” Lesniak said.

Donald F. Steiner, MD, discovers the proinsulin molecule, paving the way for the �rst synthetic insulin.

1965A birthplace of modern chemotherapy. A University of Chicago doctor uses nitrogen mustard — the active agent in the mustard gas used as a weapon in World War I — to treat leukemia and lymphoma.

1943


He and his team perform one of the highest numbers of awake craniotomies in the Chicago area — more than 30 each year. Each surgery utilizes an interdisci-plinary, experienced team of neurosur-geons, neurologists, anesthesiologists and operating room nurses.

“Dr. Lesniak showed me very quickly that he not only understood me as a patient, but also supported my journey,” Litchfield said. “I decided if there’s anybody on this planet I would literally let in my head, it would be him.”

For most of the procedure, the patient is in a state of “twilight” anesthesia, similar to what is used for dental procedures. �e procedure can last up to eight hours.

“Often I find my role is to distract the patient,” said Leo Towle, PhD, professor of neurology, surgery and pediatrics. “We talk about their kids, their hobbies.”

�e conversation is more than small talk. �roughout the surgery, the neurologist runs tests to make sure there is no loss of function. “�ey’re under the drapes asking them questions, showing them cards, asking them to count back, and I listen,” Lesniak said. “It’s like music: When there’s a note or something that sounds off, I know that we are approaching a critical area.”

�e lemon-size tumor on the right side of Litchfield’s brain was invading into the motor cortex, so it was important to monitor her ability to move the limbs on the left side of her body. When the team observed muscle weakness, the surgery was immediately stopped.

Litchfield, a teacher from Lake Forest, Ill., experienced some neurological deficits after surgery, but has seen full recovery of normal function after rehabilitation. In a procedure where the surgical team could not continually test the patient, the damage could have been permanent, Lesniak said.

microdiscs so tiny that calling them “microscopic” would be an exaggeration.

Antibodies attached to the microdiscs are capable of recognizing brain cancer cells. Once the discs reach their targets, a weak magnetic field — about the same strength as a refrigerator magnet — is applied to the cancer cells. �e discs start to rotate, which severely disrupts the cell functions. �e cancer cells self-destruct.

In theory, this therapy is potentially less toxic than the standard weapons to treat brain cancer, such as radiation and chemotherapy, which work by damaging cancer cells’ DNA but also harm healthy cells.

“�e great thing about this approach is it changes the mindset from trying to use pharmaceutical agents to do something to a cell to actually damaging the cell in a mechanical fashion,” Lesniak said.

Yamini’s NIH-funded research with nanoparticles, meanwhile, essentially tags the particles so physicians will be able to monitor their path in the desired area of the brain by MRI.

“People have previously used both targeting and image guidance in the treatment of other cancers, but bringing these two strategies together in one vehicle is something that would be really useful,” Yamini said.

If testing of the nanoparticle delivery system is successful in animal models, the next step is a clinical trial for dogs with brain tumors whose owners decide to volunteer their sick pets in order to receive a leading-edge treatment.uchospitals.edu/physicians/maciej-lesniak.html

uchospitals.edu/physicians/bakhtiar-yamini.html

Surgeon proves blood loss causes most cases of surgical shock, leading to the widespread use of blood transfusions during surgery.1930s

First hormone therapy for cancer. The 75-year-old prostate cancer patient lives another 13 years. Today, hormone therapy is used to treat several types of cancer, including breast cancer.

Janet Rowley, MD, identi�es the �rst chromosomal abnormality in leukemia, leading to the recognition of the genetic basis of cancer. In 2009, Rowley receives the Presidential Medal of Freedom, the highest civilian honor bestowed in the U.S.

At the Forefront of Medicine®

Archival Photograph Files, Special Collections Research Center, University of Chicago Library


Brain cancer is among the most

difficult malignancies to treat. Physician-scientists at the University of Chicago Medicine are researching innovative ways to make treatment easier.

Maciej S. Lesniak, MD, director of neuro-oncology research at the University of Chicago Medicine, is collaborating with scientists at the University of Chicago’s Center for Nanoscale Materials and the Materials Science Division at Argonne National Laboratory on a novel therapy that uses magnetic nanoparticles to destroy cancer cells.

And Bakhtiar Yamini, MD, assistant professor of surgery at the University of Chicago Medicine, collaborated with a Nebraska biotechnology company to design a nanoparticle “shell” capable of selectively targeting therapeutics to brain tumor cells.

Lesniak recently was awarded a five-year, $3 million grant from the National Institutes of Health to begin testing the nanomagnetic therapy in animal models.

“�ere have been advances in therapy for brain cancer, but they haven’t been significant enough to make a tremendous difference in terms of extending life,” Lesniak said.

Lesniak and his team are at the forefront of research with a total of $13 million in NIH grants to study brain tumor treatments, including gene therapy, immunotherapy and neural stem cells.

�e nanomedicine technique developed by the University of Chicago Medicine and Argonne scientists uses magnetic

A doctor-patient relationshipinspired one of the largest donations

ever pledged to theUniversity of Chicago Medicine.

University of Chicago studies conducted in two Chicago suburbs

lead to the �uoridation of water — and fewer cavities — nationwide.

World’s �rst successful living-donor liver transplant.

First successful heart-liver-kidney transplant.

Bruce A. Beutler, MD, a 1981 graduate of the Pritzker School of Medicine, wins the Nobel Prize, becoming one of 87 Nobel laureates associated with the University of Chicago.

1972 20111946-61 1989

1999A cardiac surgeon performs the �rst heart transplant, on a dog.

Early1900s

The Matthew and Carolyn Bucksbaum Family Foundation is giving $42 million to the University of Chicago to create a unique program to improve doctor-patient communication.

The Bucksbaums’ longtime physician, Mark Siegler, MD, will lead the initiative.

“Our doctor, Mark Siegler, showed us what good doctoring involved, and it was just as much about compassion and communication as his outstanding clinical competence,” Carolyn “Kay” Bucksbaum said.

“In Dr. Siegler, I have had a doctor who is interested in my husband and me as persons, not just diseases, although we’ve confronted him with a few of them. I have so valued that. A special mark of Dr. Siegler’s character is his extreme kindness and interest in what makes us tick.”

The Bucksbaum Institute for Clinical Excellence will train medical students, junior faculty members and senior clinicians to serve as role models and mentors in communication and shared decision making.

According to a 2001 study by the Commonwealth Fund, one in �ve U.S. adults had trouble communicat-ing with doctors and one in 10 felt they had been treated disrespectfully during a recent health care visit.

Kay Bucksbaum hopes the Bucksbaum Institute will address this problem by becoming a clinical and teaching model nationwide, emulated by other academic medical centers.

“This is a transformative gift, the kind that has an impact sustained over generations,” said Holly J. Humphrey, MD, dean for medical education at the University of Chicago Pritzker School of Medicine.

Eye

sw

ide

open

Patient awake, talking as surgeon removeslemon-size tumor from her brain

�e next big thing in brain cancer treatment might be very, very small

Anna Litchfield and Maciej S. Lesniak, MD

Surgery can be a daunting experience for anyone, though thanks to general anesthesia, it’s not typically a memorable one. �at’s not so for patients who go through an awake craniotomy — a unique procedure that allows surgeons to react based on feedback from the patient during removal of a brain tumor.

“I remember them waking me up, using a flashlight and talking to me,” said Anna Litchfield, 50, who was operated on in August by Maciej S. Lesniak, MD, director of neurosurgical oncology at the

University of Chicago Medicine. “I remember Dr. Lesniak saying, ‘Anna, are you OK?’ and I remember saying, ‘Great, Dr. L!’”

Awake craniotomies typically are used to remove tumors nestled close to functional areas of the brain. As the surgeon carefully removes the tumor, a neurologist monitors the patient to minimize damage to critical parts of the brain.

“When tumors are in what we call eloquent, functional areas, the margin of error is a millimeter,” Lesniak said.

Donald F. Steiner, MD, discovers the proinsulin molecule, paving the way for the �rst synthetic insulin.

1965A birthplace of modern chemotherapy. A University of Chicago doctor uses nitrogen mustard — the active agent in the mustard gas used as a weapon in World War I — to treat leukemia and lymphoma.

1943


He and his team perform one of the highest numbers of awake craniotomies in the Chicago area — more than 30 each year. Each surgery utilizes an interdisci-plinary, experienced team of neurosur-geons, neurologists, anesthesiologists and operating room nurses.

“Dr. Lesniak showed me very quickly that he not only understood me as a patient, but also supported my journey,” Litchfield said. “I decided if there’s anybody on this planet I would literally let in my head, it would be him.”

For most of the procedure, the patient is in a state of “twilight” anesthesia, similar to what is used for dental procedures. �e procedure can last up to eight hours.

“Often I find my role is to distract the patient,” said Leo Towle, PhD, professor of neurology, surgery and pediatrics. “We talk about their kids, their hobbies.”

�e conversation is more than small talk. �roughout the surgery, the neurologist runs tests to make sure there is no loss of function. “�ey’re under the drapes asking them questions, showing them cards, asking them to count back, and I listen,” Lesniak said. “It’s like music: When there’s a note or something that sounds off, I know that we are approaching a critical area.”

�e lemon-size tumor on the right side of Litchfield’s brain was invading into the motor cortex, so it was important to monitor her ability to move the limbs on the left side of her body. When the team observed muscle weakness, the surgery was immediately stopped.

Litchfield, a teacher from Lake Forest, Ill., experienced some neurological deficits after surgery, but has seen full recovery of normal function after rehabilitation. In a procedure where the surgical team could not continually test the patient, the damage could have been permanent, Lesniak said.

microdiscs so tiny that calling them “microscopic” would be an exaggeration.

Antibodies attached to the microdiscs are capable of recognizing brain cancer cells. Once the discs reach their targets, a weak magnetic field — about the same strength as a refrigerator magnet — is applied to the cancer cells. �e discs start to rotate, which severely disrupts the cell functions. �e cancer cells self-destruct.

In theory, this therapy is potentially less toxic than the standard weapons to treat brain cancer, such as radiation and chemotherapy, which work by damaging cancer cells’ DNA but also harm healthy cells.

“�e great thing about this approach is it changes the mindset from trying to use pharmaceutical agents to do something to a cell to actually damaging the cell in a mechanical fashion,” Lesniak said.

Yamini’s NIH-funded research with nanoparticles, meanwhile, essentially tags the particles so physicians will be able to monitor their path in the desired area of the brain by MRI.

“People have previously used both targeting and image guidance in the treatment of other cancers, but bringing these two strategies together in one vehicle is something that would be really useful,” Yamini said.

If testing of the nanoparticle delivery system is successful in animal models, the next step is a clinical trial for dogs with brain tumors whose owners decide to volunteer their sick pets in order to receive a leading-edge treatment.uchospitals.edu/physicians/maciej-lesniak.html

uchospitals.edu/physicians/bakhtiar-yamini.html

Surgeon proves blood loss causes most cases of surgical shock, leading to the widespread use of blood transfusions during surgery.1930s

First hormone therapy for cancer. The 75-year-old prostate cancer patient lives another 13 years. Today, hormone therapy is used to treat several types of cancer, including breast cancer.

Janet Rowley, MD, identi�es the �rst chromosomal abnormality in leukemia, leading to the recognition of the genetic basis of cancer. In 2009, Rowley receives the Presidential Medal of Freedom, the highest civilian honor bestowed in the U.S.

At the Forefront of Medicine®

Archival Photograph Files, Special Collections Research Center, University of Chicago Library


Get to know our wonderful South Side

Doriane C. Miller, MD, never

expected to become a

playwright. At a brainstorming session with community members on Chicago’s South Side, everyone loved the idea of tackling the issue of teen depression through drama. But no one knew how to write a play.

So Miller, an associate professor of medicine and director of the Center for Community Health and Vitality, did some research on playwriting techniques. Then, one evening she just started to write. By early morning, she had written half the play.

“It Shoudda Been Me,” a unique collaboration between the University of Chicago Medicine and eta Creative Arts Foundation’s Showfolk Cultural Enrich-ment Series for Youth, runs through June 15.

The play is about a 15-year-old top student whose grades plummet within months after his best friend is killed in a drive-by shooting. The storyline illustrates the need to recognize signs of depression among youth and seek out options for healing, Miller said.

Miller drew on what she has heard from young patients who have been exposed to street violence. These teens often act nonchalantly, she said, but “many of these young people exhibited symptoms of anxiety and depression, not unlike people exposed to war.”

Performances of “It Shoudda Been Me” are at 10 a.m. and noon select weekdays at eta Creative Arts Foundation Inc., 7558 S. South Chicago Ave. For ticket information, visit etacreativearts.org.

THE MUSEUM OF SCIENCEAND INDUSTRY

400,000 square feet of exhibit space makes it the largest science center in the

Western Hemisphere

Only remaining building from the 1893 World’s Columbian Exposition

1.4 million visits each year

Doriane C. Miller

museum staff on principles of psychologi-cal science featured in the Your Mind section of YOU! �e Experience. And several days a week, visitors to the exhibit get a chance to participate in psychology experiments conducted by Epley’s team of behavioral scientists.

“We thought this might be an interest-ing educational experience for museum visitors,” Epley said.

To listen to a podcast on Epley’s research into intuition and decision making, please visit msichicago.org/online-science/podcast/nicholas-epley.

For more information on the museum, visit msichicago.org

T he University of Chicago Medicine campus is located in Hyde Park, a vibrant and historic city neighborhood just a 10-minute drive along the lakefront from downtown Chicago. One of our close neighbors is the world-renowned Museum of Science and Industry.

“I grew up going to the museum and always loved visiting it,” said David Meltzer, MD, PhD, associate professor of medicine, who served on the advisory board for YOU! �e Experience, a 15,000-square-foot exhibit that explores the human mind, body and spirit.

“Serving on the advisory board, I was so impressed with the pool of expertise the museum has to draw on, and how carefully they think about their mission and how to best realize it,” Meltzer said. “�ey really think about the audiences they want to reach and try to understand what will engage them.”

University of Chicago Booth School of Business faculty members Nicholas Epley, PhD, and Reid Hastie, PhD, worked with

McBride consulted widely about the best place for treatment. All roads led to the University of Chicago Medicine.

“I knew the university had a stellar program,” she said. But conferring with luminaries during an American Associa-tion for Cancer Research meeting “sealed the deal.”

“Hands-down, they said, ‘Go to the University of Chicago.’”

McBride registered as a patient with Olufunmilayo I. Olopade, MD, an international leader in breast cancer research. McBride’s mastectomy and

subsequent breast reconstruction were performed by Nora Jaskowiak, MD, and David H. Song, MD, MBA, respectively.

“�ey’re remarkable,” she said. “�ey worked so well together,

and listened to me every step of the way.”Today, McBride draws upon her

experiences for inspiration in her role at the Noreen Fraser Foundation.

Philanthropy is especially important amid shrinking science budgets, she said.

Olufunmilayo I. Olopade, MD

curing breast cancer

Michelle McBride admits she’s “driven.” “I’m always trying to raise a little more

money,” said McBride, vice president of the Noreen Fraser Foundation, a nonprofit dedicated to supporting research into women’s cancers.

For McBride, it’s personal.On Dec. 11, 2011, she turned 39 years

and 24 days old. It’s not a milestone most of us would mark, but for McBride, of Glencoe, Ill., it held special significance. Both her mother and grandmother had died young, and McBride had, on that day, lived longer than her mom had. “When your mother dies young, it’s natural to assume you’ll die young too — especially when your grandmother also died early,” explained McBride. “My husband and I were up until midnight; I turned to the clock and said, ‘I made it.’”

For McBride, a mother of three, it had been an arduous journey. Sensitized to her familial risk of cancer by watching her mother succumb to the disease at 39 and the knowledge that her grandmother had died of it at 44, she underwent a test in 2006 that found a particular genetic mutation. It meant her odds of getting breast cancer were 87 percent. She stood a 27 percent chance of developing ovarian cancer.

“I cried,” she recalled. “I was sad my mother didn’t have the chance to learn what I had about our genetic makeup and to do something that could have prevented her death.”

McBride, a former attorney, embarked on a course of screening and self-education that culminated in her decision — in her mid-30s and without any indication of cancer — to have her breasts and ovaries removed.

She documented her experiences in a series of moving online journal entries.

“I am trying to break a pattern that is woven into my genetic fiber,” she wrote after deciding on the mastectomy.

Michelle McBride with her daughters London, 7, and Lola, 4

Michelle McBride supports research so other women will be spared the tough decisions she faced

For information on how to support cancer research at the University of Chicago Medicine, please contact Amanda Nunnink at [email protected].

To learn more about the Noreen Fraser Foundation, visit noreenfraserfoundation.org.

Residents of several city neighborhoods have been vaccinated against the �u this season, thanks to students at the University of Chicago Pritzker School of Medicine.

Under physician supervision, �rst- and second-year students administered more than 500 �u vaccines to community members during �u vaccine drives in Chicago’s Chinatown and Little Village neighborhoods and on the city’s South Side.

Pritzker students gained an appreciation for Chicago’s diverse neighborhoods and immigrant populations and had the chance to talk with community members in Spanish and Chinese.

Along with giving �u shots, the future physicians took blood pressure readings and administered glucose screenings at the Chinatown Health Fair. Students also participated in Community Prostate Awareness Day on the South Side, giving free PSA tests to screen for prostate cancer.

STUDENTS GIVE BACK TO IMPROVE COMMUNITY HEALTH

Pritzker School of Medicine student David Bluhm immunizes a young soccer player at the ¡Gol…A Tú Salud! Health Fair.


“We’re making such strides in research that it’s imperative to continue supporting groundbreaking work.”

One project the foundation supports — through a $150,000 grant — is Olopade’s pioneering 4,000-patient study of triple-negative breast cancer, a virulent cancer that disproportionately strikes women of African descent.

“�eir funding is vital,” said Olopade. “We want to prevent breast cancer through better risk assessment, improved guidance on lifestyle changes, new therapies and less-invasive procedures.

“Our hope is that one day women like Michelle will be spared the tough decisions she faced.”

Support Comer Children’s Hospital at theUniversity of Chicago Medicine through

the House of Dreams Charity Raffle.Enter at houseofdreamsraffle.org for the

chance to win a house or$1 million in cash.

Get to know our wonderful South Side

Doriane C. Miller, MD, never

expected to become a

playwright. At a brainstorming session with community members on Chicago’s South Side, everyone loved the idea of tackling the issue of teen depression through drama. But no one knew how to write a play.

So Miller, an associate professor of medicine and director of the Center for Community Health and Vitality, did some research on playwriting techniques. Then, one evening she just started to write. By early morning, she had written half the play.

“It Shoudda Been Me,” a unique collaboration between the University of Chicago Medicine and eta Creative Arts Foundation’s Showfolk Cultural Enrich-ment Series for Youth, runs through June 15.

The play is about a 15-year-old top student whose grades plummet within months after his best friend is killed in a drive-by shooting. The storyline illustrates the need to recognize signs of depression among youth and seek out options for healing, Miller said.

Miller drew on what she has heard from young patients who have been exposed to street violence. These teens often act nonchalantly, she said, but “many of these young people exhibited symptoms of anxiety and depression, not unlike people exposed to war.”

Performances of “It Shoudda Been Me” are at 10 a.m. and noon select weekdays at eta Creative Arts Foundation Inc., 7558 S. South Chicago Ave. For ticket information, visit etacreativearts.org.

THE MUSEUM OF SCIENCEAND INDUSTRY

400,000 square feet of exhibit space makes it the largest science center in the

Western Hemisphere

Only remaining building from the 1893 World’s Columbian Exposition

1.4 million visits each year

Doriane C. Miller

museum staff on principles of psychologi-cal science featured in the Your Mind section of YOU! �e Experience. And several days a week, visitors to the exhibit get a chance to participate in psychology experiments conducted by Epley’s team of behavioral scientists.

“We thought this might be an interest-ing educational experience for museum visitors,” Epley said.

To listen to a podcast on Epley’s research into intuition and decision making, please visit msichicago.org/online-science/podcast/nicholas-epley.

For more information on the museum, visit msichicago.org

T he University of Chicago Medicine campus is located in Hyde Park, a vibrant and historic city neighborhood just a 10-minute drive along the lakefront from downtown Chicago. One of our close neighbors is the world-renowned Museum of Science and Industry.

“I grew up going to the museum and always loved visiting it,” said David Meltzer, MD, PhD, associate professor of medicine, who served on the advisory board for YOU! �e Experience, a 15,000-square-foot exhibit that explores the human mind, body and spirit.

“Serving on the advisory board, I was so impressed with the pool of expertise the museum has to draw on, and how carefully they think about their mission and how to best realize it,” Meltzer said. “�ey really think about the audiences they want to reach and try to understand what will engage them.”

University of Chicago Booth School of Business faculty members Nicholas Epley, PhD, and Reid Hastie, PhD, worked with

McBride consulted widely about the best place for treatment. All roads led to the University of Chicago Medicine.

“I knew the university had a stellar program,” she said. But conferring with luminaries during an American Associa-tion for Cancer Research meeting “sealed the deal.”

“Hands-down, they said, ‘Go to the University of Chicago.’”

McBride registered as a patient with Olufunmilayo I. Olopade, MD, an international leader in breast cancer research. McBride’s mastectomy and

subsequent breast reconstruction were performed by Nora Jaskowiak, MD, and David H. Song, MD, MBA, respectively.

“�ey’re remarkable,” she said. “�ey worked so well together,

and listened to me every step of the way.”Today, McBride draws upon her

experiences for inspiration in her role at the Noreen Fraser Foundation.

Philanthropy is especially important amid shrinking science budgets, she said.

Olufunmilayo I. Olopade, MD

curing breast cancer

Michelle McBride admits she’s “driven.” “I’m always trying to raise a little more

money,” said McBride, vice president of the Noreen Fraser Foundation, a nonprofit dedicated to supporting research into women’s cancers.

For McBride, it’s personal.On Dec. 11, 2011, she turned 39 years

and 24 days old. It’s not a milestone most of us would mark, but for McBride, of Glencoe, Ill., it held special significance. Both her mother and grandmother had died young, and McBride had, on that day, lived longer than her mom had. “When your mother dies young, it’s natural to assume you’ll die young too — especially when your grandmother also died early,” explained McBride. “My husband and I were up until midnight; I turned to the clock and said, ‘I made it.’”

For McBride, a mother of three, it had been an arduous journey. Sensitized to her familial risk of cancer by watching her mother succumb to the disease at 39 and the knowledge that her grandmother had died of it at 44, she underwent a test in 2006 that found a particular genetic mutation. It meant her odds of getting breast cancer were 87 percent. She stood a 27 percent chance of developing ovarian cancer.

“I cried,” she recalled. “I was sad my mother didn’t have the chance to learn what I had about our genetic makeup and to do something that could have prevented her death.”

McBride, a former attorney, embarked on a course of screening and self-education that culminated in her decision — in her mid-30s and without any indication of cancer — to have her breasts and ovaries removed.

She documented her experiences in a series of moving online journal entries.

“I am trying to break a pattern that is woven into my genetic fiber,” she wrote after deciding on the mastectomy.

Michelle McBride with her daughters London, 7, and Lola, 4

Michelle McBride supports research so other women will be spared the tough decisions she faced

For information on how to support cancer research at the University of Chicago Medicine, please contact Amanda Nunnink at [email protected].

To learn more about the Noreen Fraser Foundation, visit noreenfraserfoundation.org.

Residents of several city neighborhoods have been vaccinated against the �u this season, thanks to students at the University of Chicago Pritzker School of Medicine.

Under physician supervision, �rst- and second-year students administered more than 500 �u vaccines to community members during �u vaccine drives in Chicago’s Chinatown and Little Village neighborhoods and on the city’s South Side.

Pritzker students gained an appreciation for Chicago’s diverse neighborhoods and immigrant populations and had the chance to talk with community members in Spanish and Chinese.

Along with giving �u shots, the future physicians took blood pressure readings and administered glucose screenings at the Chinatown Health Fair. Students also participated in Community Prostate Awareness Day on the South Side, giving free PSA tests to screen for prostate cancer.

STUDENTS GIVE BACK TO IMPROVE COMMUNITY HEALTH

Pritzker School of Medicine student David Bluhm immunizes a young soccer player at the ¡Gol…A Tú Salud! Health Fair.


“We’re making such strides in research that it’s imperative to continue supporting groundbreaking work.”

One project the foundation supports — through a $150,000 grant — is Olopade’s pioneering 4,000-patient study of triple-negative breast cancer, a virulent cancer that disproportionately strikes women of African descent.

“�eir funding is vital,” said Olopade. “We want to prevent breast cancer through better risk assessment, improved guidance on lifestyle changes, new therapies and less-invasive procedures.

“Our hope is that one day women like Michelle will be spared the tough decisions she faced.”

Support Comer Children’s Hospital at theUniversity of Chicago Medicine through

the House of Dreams Charity Raffle.Enter at houseofdreamsraffle.org for the

chance to win a house or$1 million in cash.

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For more inFormation, visit nhp.uchospitals.edu

Our New HospitalAt the ForeFront oF CAre And disCoverysm

opening January 2013

Our new hospital will provide patients and their physicians with a facility capable of transforming itself as rapidly as medicine is changing.

Its design is committed not simply to today’s ideal, but to a vision of perpetual and unpredictable change in patient care and clinical research. This vision is built on the University of Chicago Medicine’s fundamental

commitment to discovery, innovation and collaboration.

5841 s. maryland ave.

Chicago, iL 60637


Physician referrals: 1-800-824-2282

nhp.uchospitals.edu

FAst FACts About the new hospitAl

1.2 million total square feet

550 average number of construction workers on a peak day

2 million+ total estimated work hours to build the NHP

96 hours How long the new hospital can operate in case of a power outage

1,800 additional planned parking spaces. garage to be built north of the hospital

2 Wireless bands — one reserved for hospital use, one for patients and visitors

100,000 total number of plants on the roof — hardy, drought-resistant sedums

“A hospital has not only the goal but the obligation to be inspirational. When you come as a patient, or with a family member, the experience of the architecture is something that has to give you not only hope, but clarity, peace.”raFaeL viÑoLy | Architect

The new hospital is designed for family-centered care and improved commun-ication among all members of the patient’s care team.

privACy And

ComFort Our 240 inpatient rooms are all single occupancy and spacious enough to accommodate family for overnight stays. Each room will have a flat-screen TV and a reading light, so a family member can read without disturb-ing the patient.

Spirit-lifting

views All patient rooms are on the perimeter of the build-ing for greater privacy. Large windows provide spectacular views of the University of Chicago campus and the Chicago skyline.

room serviCe

Patients will be able to order what they want to eat, when they want to eat (within dietary restrictions).

peACe And quiet

Dual-layer window coverings include a blackout layer to darken the room for

better sleep. The new paging system does not rely on overhead pages.

FAmily support

The 10th floor will have two exercise rooms for patients and their families to use. Family members will be able to follow their loved one’s progress from pre-op to recovery on electronic boards — similar to the ones in airports — in the surgery waiting area. Patients will be identified by number for privacy.

a healing environment for patients and families

ArchitecturAl drAwing of A pAtient room

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“ The new hospital will empower us to deliver world-class, leading-edge care to patients facing the most challenging, complex conditions and to drive new breakthrough treatments for patients.”

KeNNetH S. PoloNSKy, MD Dean of the Biological Sciences Division and the Pritzker School of Medicine and Executive Vice President for Medical Affairs

“ The new hospital will allow us to make a great leap forward, especially in the field of integrated multispecialty care — a hallmark of future cancer care.”

everett e. voKeS, MD Physician-in-Chief and Chair of the Department of Medicine

“ It is a design for the future that allows rapid integration of new technologies for advanced care in a way that maintains the patient and family at the center of the care.”

Jeffrey B. MAttHewS, MD surgeon-in-Chief and Chair of the Department of Surgery

Leading-edge Care

ArchitecturAl drAwing of the new hoSpitAl

the neW hospital:an economic engine for the community

The new hospital is the largest single health-care investment in the history of the University of Chicago Medicine.

And from the beginning of construction in 2009, the $700 million project has fostered the participation of minority- and women-owned enterprises.

The massive project continues a renewed tradition of commitment by the University of Chicago Medicine to making a significant impact not just on the medical health, but also on the economic health of the surrounding community. As an employer and provider, the medical center provides stability and growth for the South Side.

The University of Chicago Medicine launched its initiative to improve participation by minority- and women-owned businesses in construction and other projects more than a decade ago.

“ This building offers a tremendous opportunity to transform how we care for patients, from innovative technology that delivers the most advanced clinical treatments and improves safety, to amenities that offer a superior healing environment.”

SHAroN o’Keefe President of the University of Chicago Medical Center

ArchitecturAl drAwing of the lobby

ArchitecturAl drAwing of the new hoSpitAl

programmed for 28 operating rooms with leading-edge technology

green roof planted with 100,000 drought-resistant plants

two exercise rooms for patients and their families to use

two floors of expansion space for future technology

retail space along 57th street

Cancer care

Our New Hospital

the Sky lobby’s floor-to-ceiling glass windows offer panoramic views of the city

240 private inpatient rooms, including iCu

pharmacy

Blood bank

Heliport

integrated diagnostic and interventional platform includes cardiac, gastrointestinal,

neurological and vascular services

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Documents

Imagine - Spring 2012 - University of Chicago Medicine