1© 2014 Amplify, Inc.

IDENTIFY MOLECULES AND ORGANELLES

As you get to know the simulation, it’s important to take a moment to write down what

you’re observing in the cell.

A key part of science is taking good notes and figuring out how best to present your

information to others. Throughout this entire lesson on cells, we’ll be discussing

different ways of presenting what you learn. We’ll start with a simple list.

There are six kinds of molecules in the simulation. Can you find and name them all?

There are seven kinds of organelles in the simulation. Can you find and name them all?

MoleculesSmall structures that travel throughout thebody, cells and organelles and keep them allfunctioning.

OrganellesStructures inside the cell that perform basic jobs using the molecules to keep the cell healthy and alive.

Student Name ________

2© 2014 Amplify, Inc.

UNDERSTANDING SCALES INSIDE THE BODY

Student Name ________

Order the following items by size, with smallest at the top and biggest at the bottom.

Organelle Cell Tissue Molecule Organ Human

3© 2014 Amplify, Inc.

INVESTIGATION OF ORGANELLES

Use the simulator to continue your investigation into the cell, organelles, and

molecules. Figure out which molecule or molecules enter and which molecule or

molecules leave for each organelle listed below. This is the first step to making a larger

model for tracing how all molecules travel through a cell.

Student Name ________

4© 2014 Amplify, Inc.

CELLULAR INPUTS/OUTPUTS

You have investigated what’s happening inside the cell, but how does the cell system

connect to the rest of the organism? Can you figure out which molecules the cell gets

from outside? And what molecules does the cell produce and send outside the cell?

Student Name ________

Cell Membrane

Bloodstream

Leaves t

he cell

Leaves t

he cell

Enters the Cell

Enters the Cell

5© 2014 Amplify, Inc.

SESSION 2 EXIT TICKET

Use the words in the box below to complete the sentences below.

Which molecule goes into the mitochondria?

______________ goes into the mitochondria.

Which molecule is made by ribosomes?

Ribosomes produce _______________.

Student Name ________

Glucose Carbon dioxide ATP mRNA Proteins

6© 2014 Amplify, Inc.

WORKING WITH GRAPHS: CHOKING Student Name ________

With a partner, create a graph that shows the effects of choking on the molecules

inside a cell. Which molecules will you graph to provide the best description? How are

they affected -- do their numbers go up or down?

[ ]No oxygen

Time

Am

ou

nt

of

Mo

lecu

les

CHOKING

High

Low

7© 2014 Amplify, Inc.

WORKING WITH GRAPHS: STARVING Student Name ________

With a partner, create a graph that shows the effects of starving on the molecules

inside a cell. Which molecules will you graph to provide the best description? How are

they affected -- do their numbers go up or down?

[ ]No Glucose

Time

Am

ou

nt

of

Mo

lecu

les

in t

he

Cel

l

STARVING

High

Low

8© 2014 Amplify, Inc.

REVIEW YOUR MODELS: ANIMAL CELL

Fill in the labels on the drawing below to show how you think the system works.

Student Name ________

Ribosome

Cell Membrane

Nucleus

Mitochondria

9© 2014 Amplify, Inc.

CHOKING HYPOTHESIS

Using the model for a cell, put an “X” over organelles that won’t work when a cell

doesn’t get oxygen.

Student Name ________

Ribosome

Cell Membrane

Nucleus

Mitochondria

Carbon Dioxide (CO2)

Protein (cellular tools)

mRNA(instructions)

ATP(energy)

Glucose (sugar)

Oxygen(O2)

Write an explanation for your answers: What do you think happens in the cell when

someone’s choking? Using your model, think about the effect on organelles, molecules,

and the cell as a whole. Be specific!

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10© 2014 Amplify, Inc.

STARVING HYPOTHESIS

Using the model for a cell, put an “X” over organelles that won’t work when a cell

doesn’t get glucose.

Student Name ________

Ribosome

Cell Membrane

Nucleus

Mitochondria

Carbon Dioxide (CO2)

Protein (cellular tools)

mRNA(instructions)

ATP(energy)

Glucose (sugar)

Oxygen(O2)

Write an explanation for your answers: What do you think happens in the cell when

someone’s starving? Using your model, think about the effect on organelles, molecules,

and the cell as a whole. Be specific!

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11© 2014 Amplify, Inc.

SESSION 3 EXIT TICKET

Sum up what happens when someone chokes or starves. Talk about both the whole body

and the cell.

What evidence have you found in the cell to support this?

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Student Name ________

12© 2014 Amplify, Inc.

EXPLORING INSULIN IN THE CELL PREDICTION

You’ve made a decision as a class on which organelles you’re going to investigate. Write

down which they are and explain why we have chosen those.

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Student Name ________

13© 2014 Amplify, Inc.

CELL MEMBRANE RESEARCHERS

You are a Cell Membrane Researcher. Your job is to think about how the cell membrane

works with glucose.

The cell membrane allows ______________ and ________________ to enter the cell.

Student Name ________

Glucose

14© 2014 Amplify, Inc.

CELL MEMBRANE RESEARCHERS

What about the glucose? If the cell membrane stops working, the amount of glucose

inside the cell will:

a. go up

b. go down

c. stay the same

Why do you think that?

______________________________________________________________________________

______________________________________________________________________________

______________________________________________________________________________

Student Name ________

Glucose

15© 2014 Amplify, Inc.

MITOCHONDRIA RESEARCHERS

You are a Mitochondria Researcher. Your job is to think about how the mitochondria

works with glucose.

The mitochondria uses _________ and _________ to make _________ and _________.

Student Name ________

Glucose

16© 2014 Amplify, Inc.

MITOCHONDRIA RESEARCHERS

What about the glucose? If the mitochondria stops working, the amount of glucose

inside the cell will:

a. go up

b. go down

c. stay the same

Why do you think that?

______________________________________________________________________________

______________________________________________________________________________

______________________________________________________________________________

Student Name ________

Glucose

17© 2014 Amplify, Inc.

MITOCHONDRIA PREDICTION Student Name ________

You have predicted that if insulin acts on the mitochondria, without insulin, glucose

inside the cell will increase.

Glucose

18© 2014 Amplify, Inc.

MITOCHONDRIA PREDICTION Student Name ________

Translate the prediction you made into a graph.

Time when insulin stops[ ]

High

Low

Time

Am

ou

nt

of

Glu

cose

in C

ell

19© 2014 Amplify, Inc.

CELL MEMBRANE PREDICTION Student Name ________

You have predicted that if insulin acts on the cell membrane, without insulin, glucose

inside the cell will decrease.

Glucose

20© 2014 Amplify, Inc.

CELL MEMBRANE PREDICTION Student Name ________

Translate the prediction you made into a graph.

Time when insulin stops[ ]

High

Low

Time

Am

ou

nt

of

Glu

cose

in C

ell

21© 2014 Amplify, Inc.

COMPETING CLAIMS

Fill in the table below as a way of organizing your investigation.

Student Name ________

Mitochondria research

Hypothesis: State what you are investigating.

Insulin helps the mitochondria Insulin helps the cell membrane

The amount of glucose in the cell will increase

The amount of glucose in the cell will decrease

The cell can’t use the glucose that comes in, so it piles up unused

No more glucose can come into the cell

Prediction: Without insulin, would the amount of glucose increase or decrease inside the cell?

Reasoning: Why would the amount of glucose increase or decrease?

Cell Membrane research

22© 2014 Amplify, Inc.

SESSION 4 EXIT TICKET

Based on what you observed in the simulation, circle the organelle that insulin

acts on.

You’ve just completed a challenging scientific investigation! Scientists often write up

reports after they conclude an investigation. Describe what you researched and what

you discovered. Make sure your answer includes the answer to these questions:

1. What happens in the bloodstream when you have diabetes?

2. What organelle does insulin work on?

3. What happens inside a diabetic cell without insulin?

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Student Name ________

Mitochondria or Cell Membrane

23© 2014 Amplify, Inc.

MAPPING THE ORGANELLES

Please fill out the diagram below, writing the organelles in the correct area -- plants

only, animals only, or plants and animals.

Plant AnimalPlant and Animal

Student Name ________

24© 2014 Amplify, Inc.

INVESTIGATION OF PLANT CELL ORGANELLES

Do the mitochondria, nucleus and ribosome do the same thing in the plant cell as they

did in the animal cell? And what about this new organelle, the chloroplast? What does

that do? How does it contribute to the system?

Fill the labels with the appropriate input and outputs for the plant cell’s organelles.

Student Name ________

25© 2014 Amplify, Inc.

REVIEW YOUR PLANT CELL MODEL WORKSHEET

Input the correct molecules into the drawing to show how the plant cell system works.

Student Name ________

26© 2014 Amplify, Inc.

SESSION 5 EXIT TICKET

1. “All life on Earth is dependent on plants.” Do you agree or disagree with this

statement?

Explain your reasoning.

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2. “Some animals, like lions, survive by only eating other animals for food. What do

you think would happen to lions if all the plants on Earth disappeared?”

A. Since lions do not eat plants, lions would survive if there were no plants.

B. Since lions only depend on animals for their food, lions would survive if there

were no plants.

C. Since lions are at the top of the food web and eat everything that is lower in the

food web, lions would survive if there were no plants.

D. Since lions eat animals that eat plants, lions would not survive if there were no

plants.

Student Name ________

Agree Disagree