ICESA 2019icesa2019.gaics.org/site/userdata/1257/file/Conference Program of I… · ICESA 2019 Osaka International House Foundation, Osaka, Japan August 28-30, 2019 3 Welcome from

ICESA 2019

2019 International Conference on

Engineering, Science and Applications

http://ICESA2019.gaics.org

Conference Organizers

Global Academic-Industrial Cooperation Society

Kuwait University

Ara Institute of Canterbury

Ritsumeikan University

Osaka International House Foundation, Osaka, Japan

August 28-30, 2019

ICESA 2019


August 28-30, 2019

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Contents

Welcome from the ICESA Conference Chairs ................................................................................................3

Committee ...........................................................................................................................................................4

Keynote Speaker 1 ..............................................................................................................................................6

Keynote Speaker 2 ..............................................................................................................................................7

Conference Schedule ..........................................................................................................................................8

Conference Floor Map ..................................................................................................................................... 11

Guidelines for Presenting Authors and Session Chairs ................................................................................ 12

Session: C4 ........................................................................................................................................................ 13

ICESA_0063 .................................................................................................................................................. 14 Electro-magnetic smart cement/concrete based on desired electromagnetic transport through structure ICESA_0070 .................................................................................................................................................. 15 River Flow Analysis and Implications in Water Resource Management and Policy Design ICESA_0071 .................................................................................................................................................. 16 Challenges in Marine Environmental Management – A Call for Scientific Innovation in Fighting Plastic

Pollution

Session: B5 ......................................................................................................................................................... 17

ICESA_0055 .................................................................................................................................................. 18 Building a Quality-based Risk Management Taxonomy for Information Systems Development and

Management ICESA_0057 .................................................................................................................................................. 19

Modeling and Analysis of System Risk Exposure Using the Petri Net Model ICESA_0062 .................................................................................................................................................. 20 Numerical Simulation of Droplet Drying and Solute Precipitation ICESA_0069 .................................................................................................................................................. 21 Response Delay Improvement of Following Vehicle Prototype

Session: Room Sakura (east) 2 ........................................................................................................................ 22

ICESA_0029 .................................................................................................................................................. 24 Fuzzy Decision Modeling for a Closed-loop Supply Chain with Asymmetric Information ICESA_0032 .................................................................................................................................................. 25 Optimization of the insecticidal activity of Photorhabdus luminescens 0805-P2R fermentation conditions on

Plutella xylostella ICESA_0034 .................................................................................................................................................. 26 Gallic Acid from Mangroves as potent sPLA2 inhibitory compound: Binding Studies ICESA_0037 .................................................................................................................................................. 27 A Collusive Cheating Method for Visual Cryptography Schemes ICESA_0043 .................................................................................................................................................. 28 A Formal Description Method of Asynchronous Event Sequences Using Shuffle Expressions ICESA_0045 .................................................................................................................................................. 29 An intelligent wearable biosensor for blood pressure prediction based on photoplethysmography

ICESA_0046 .................................................................................................................................................. 30 Low-Complexity Beam Selection for Massive MIMO Systems ICESA_0058 .................................................................................................................................................. 31 Uptake and Accumulation of Maize、Vetiver and Physic Nut for PCDD/Fs-contaminated Soil ICESA_0060 .................................................................................................................................................. 32

ICESA 2019


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Self-Assembled Activin A- and Bone Morphogenetic Protein 4-Grafted Poly(vinyl alcohol)-Alginate-

Gelatin Hydrogel with Retinoic AcidLoaded Solid Lipid Nanoparticles for Pancreatic Differentiation of iPS

Cells ICESA_0061 .................................................................................................................................................. 33

Apolipoprotein E-Conjugated Phosphatidic Acid-Liposomes with Encapsulated Quercetin- and Rosmarinic

Acid against Phosphorylation of Mitogen-Activated Protein Kinases In Vivo

Access to Conference Venue ............................................................................................................................ 34

Osaka City Route Map ..................................................................................................................................... 37

ICESA 2019


August 28-30, 2019

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Welcome from the ICESA Conference Chairs

On behalf of the Organizing Committee, we are honored and delighted to welcome you to the 2019

International Conference on Engineering, Science and Applications (ICESA), held at Osaka

International House Foundation, Osaka, Japan on August 28-30, 2019, which is jointly together with

the International Conference on Education and Learning (ICEL), International Conference on

Hospitality, Tourism, and Sports Management (HTSM), International Conference on Health, Nutrition,

and Exercise Science (HNES), and International Conference on Industry, Business and Social Sciences

(IBSS). Together these conferences form the 2019 Global Academic-Industrial Cooperation Society

(GAICS) Joint Conference in Osaka, Japan.

These five conferences operate separately but are managed and organized under the Global

Academic-Industrial Cooperation Society (GAICS). The 2019 GAICS Joint Conference in Osaka,

Japan is a prestigious gathering of researchers held to share and strengthen interdisciplinary research

around the world. This event is a great opportunity for all attendees to share new findings and research

results, as well as seek collaborative opportunities across disciplines.

We know that the success of the conference depends ultimately on the many people who have

participated and have worked with us in planning and organizing both the technical program and

supporting social arrangements. Therefore, we would like to take this opportunity to express our

heartfelt thanks to all committee members, reviewers, session chairs, presenters, and organization staff.

In addition, a special thanks would like to be given to Dr. Yuko Yato and Dr. Yukako Wada for helping

host the conference and to Dr. Kassem A. Saleh and Dr. Masafumi Terada for their keynote speech.

If Kyoto was the city of the courtly nobility and Tokyo was the city of the samurai, then Osaka was

the city of the merchant class. Osakans take pride in shedding the conservatism found elsewhere in

Japan, and this spirited city – Japan's third-largest – is a place where people are a bit brasher and

interactions are peppered with playful jabs. Greater Osaka has an extensive network of railway lines,

comparable to that of Greater Tokyo. Major stations within the city include Umeda, Namba,

Shinsaibashi, Tennōji, Kyōbashi, and Yodoyabashi.

Finally, we hope this conference will be a great success and will be fruitful to all participants in

both academic and social aspects. We also hope that you will enjoy your stay in Osaka.

Dr. Kassem A. Saleh, ICESA 2019 Conference Chair

Dr. Mehdi Asgarkhani, ICESA 2019 Conference Co-Chair

August 28, 2019

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Committee

Conference Chair

Professor Kassem Saleh.

Conference Chair of ICESA 2019

Kuwait University, Kuwait

Conference Co-Chair

Mehdi Asgarkhani, Ph.D.

Conference Co-Chair of ICESA 2019

Department of Computing

Acting Chair, Canterbury Board of the Institute of IT

Professionals

Ara Institute of Canterbury, New Zealand

Local Conference Chair

Yuko Yato, Ph.D.

Conference Local Chair

Ritsumeikan University Osaka Ibaraki Campus, Osaka, Japan

Local Conference Co-Chair

Yukako Wada, Ph.D.

Conference Local Co-Chair

Ritsumeikan University Biwako-Kusatsu Campus, Shiga, Japan

ICESA 2019


August 28-30, 2019

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Advisory Committee Members Sebastian Blankemeyer, Germany

Mona Nagieb Eskander, Egypt

Hussein Mishbak, United Kingdom

Chika Yoshida, Japan

International Committee Members Beum-Soo An, Pusan National University, Korea

Sri Andayani, Brawijaya University, Indonesia

Mehdi Asgarkhani, Ara Institute of Canterbury, New Zealand

Somayeh Ghasemzadeh Baraki, Azad university of Tehran, Iran

Bloul Benattia, University Boumerdes, Algeria

Mohamed Boumaza, Université de Bejaia, Algeria

Michel Chalhoub, Notre Dame University, Lebanon

Yung Hyun Choi, Dongeui University , Korea

Foundere Coulibaly, National Laboratory of Public Health, Lvory Coast

Mahmoud Elsayed, Fayoum University, Egypt

Mona Eskander, Electronics Research Institute, Egypt

Mohamad Fadjar, University of Brawijaya, Indonesia

Mitra Gholami, Iran University of Medical Sciences, Iran

Endang Herawati, Brawijaya University, Indonesia

Woo Tae Hong, Pukyong National University, Korea

Riccardo Introzzi, Politecnico di Torino, Italy

Reza Jafarinia, Islamic Azad university, Iran

Joonhyeon Jeon, Dongguk University, Korea

Woocheol Lee, Pukyong National University, Korea

Kwangmo Lim, The University of Suwon, Korea

En Lu, China University of Mining and Technology, China

Kai Long Mak, The Hong Kong Polytechnic University, Hong Kong

Sarah Makled, Faculty of Science , Egypt

Hussein Mishbak, The university of Manchester, UK

Sweta Mohan, Indian Institute of Technology (Banaras Hindu University), India

Meena Momand, Kobe Institute of Computing, Japan

Aumnad Phdungsilp, Dhurakij Pundit University, Thailand

Prayitno, State polytechnic of malang, Indonesia

Prissana Sangkhum, Chulalongkorn University, Thailand

Tsutomu Sekine, Seikei University, Japan

Lianchao Sheng, China University of Mining and Technology, China

Teera Siriteerakul, King Mongkut's Institute of Technology, Thailand

Weiguang Wang, The University of Manchester, UK

Wenjing Wang, The University of Queensland, Australia

Hyun Kyoung Yang, Pukyong National University, Korea

Emil Yankov, University of Ruse, Bulgaria

Chika Yoshida, Kobe Institute of Computing Graduate School, Japan

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August 28-30, 2019

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Keynote Speaker 1

Kassem A. Saleh, Ph.D., PMI PMP-RMP

Dr. Kassem A. Saleh received his BSc, MSc, and PhD in

Computer Science from the University of Ottawa in Canada. Dr.

Saleh worked as a Software Design Engineer at Northern Telecom

in 1984 and then as a Computer Systems Specialist at Mediatel,

Bell Canada, from 1985 to 1991. Kassem was on the faculty of

Concordia University in 1992, Kuwait University from 1992 to

2000, and the American University of Sharjah from 2000 to 2007.

He is currently Professor in Information Sciences at Kuwait

University. His research interests include software engineering,

information security, quality and risk management and project

management. Dr. Saleh has published more than 130 refereed

journal and conference papers and one textbook on Software

Engineering and has presented numerous tutorials, lectures and

invite talks at international conferences and universities. The

Journal of Systems and Software has ranked Dr. Saleh among the

top ten scholars in the field of systems and software engineering

in eight of its annual assessments published from 1996 to 2003.

Dr Saleh holds professional certifications in software engineering

(IEEE CSEM), information security (ISC2 CISSP), project (PMI

PMP) and risk management (PMI PMP-RMP), quality

engineering (ASQ CQE, ASQ CSQE) and business analysis (PMI

PMP-BA).

TOPIC: Risk Management for Successful Projects and Operations - Why and How?

Abstract

Risks are facts of our lives whether personally or at work. Risks can be positive (opportunities) or

negative (threats). They should be managed and treated properly, continuously and systematically

otherwise undesirable situations and outcomes, and missed opportunities may result leading to

business failures, loss of competitiveness and disasters. The proper use of risk management skills is

one of the major requirements for planning and executing successful projects and operations in

enterprises. In this talk, you will be exposed to the systematic processes that need to be performed to

manage risks and deal with them should they become a reality. In particular, we will talk about the

various risk response strategies used to treat positive and negative risks.

ICESA 2019


August 28-30, 2019

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Keynote Speaker 2

Masafumi Terada, Ph.D., ATC Dr. Terada is the assistant professor at Ritsumeikan University

where he holds academic appointments in Faculty of Sport and

Health Science. He earned his BS from University of Nebraska

at Kearney, and his MS and Ph.D. from the University of

Toledo. He also completed post-doctoral training at the

University of Kentucky. His primary area of research deals with

ankle and knee injuries to reduce the long-term consequences of

these conditions over the lifespan. He studies these injuries from

a multifactorial perspective using diverse tools ranging from

laboratory- based outcome measures of biomechanics and

motor control to patient-generated outcome measures. In his

career, Dr. Terada has over 30 published and/or in-press peer-

reviewed manuscripts in scientific journals and has presented

over 60 abstracts at international, national and regional

scientific meetings.

TOPIC: An Interdisciplinary Approach to Sport Injury Prevention and Management

Abstract

Participation in sports and physical activities has an important role in a healthy lifestyle. However, it

is associated with an inherent risk of musculoskeletal injury. Musculoskeletal injuries represent the

second greatest cause of disability worldwide. With increasing government and society emphasis on

sport and physical activity, the number of musculoskeletal injuries will remain constant or increase as

more individuals participate in physical activities. It is critical to establish a more cost-effective and

efficient method for preventing and managing musculoskeletal injury. Successful sports health care is

interdisciplinary in nature. An interdisciplinary approach plays an integral role in reducing risk of

sustaining of musculoskeletal injuries during sports and physical activities. The interdisciplinary

approach provides the current best evidence regarding the use of translating the novel biomechanics

techniques into clinical practice. Therefore, collaborations within the broader fields of sports medicine

can improve clinical outcomes for patients with a musculoskeletal injury. This talk will feature an

interdisciplinary team that has shown a unique set of skills that enable us to tackle the cutting-edge

approaches of preventing and managing sport injury. At the conclusion of the program, participants

will be able to explain the benefits of a collaborative approach to sport injury prevention and

management.

ICESA 2019


August 28-30, 2019

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IBSS, ICEL, ICESA, HTSM, HNES 2019

Conference Schedule

August 28, 2019 (Wednesday)

08:00-15:30 Half-Day Local Tour

15:30-17:30 Check In & Welcome Reception Party

Time Event

08:00-15:30 Industry Tour

08:00-08:15 Meet Up

Osaka International House Foundation

08:15 Departure

09:15

Visit

The Momofuku Ando Instant

Ramen Museum

12:00 Lunch Time

13:30

Visit

The Entrepreneurial Museum of

Challenge and Innovation

15:00 Return

15:30 Arrival


15:30-17:30 Check In & Welcome Reception Party


ICESA 2019


August 28-30, 2019

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Conference Schedule

August 29, 2019 (Thursday)

ICESA International Committee Meeting at 15:00 in Room 1 Floor 3rd

Time

Room

Event

(Session) A (Session) B (Session) C Sakura (east)

09:00-16:00 Check In

09:30-10:30

Room Sakura (east)

Opening Ceremony

Keynote Speeches

Distinguished Papers Award

10:30-10:50 Coffee & Tea Break

10:50-12:10

A1 B1 C1 Room Sakura (east) 1

HTSM

(Oral)

#0030 #0048

#0082 #0090

HTSM

(Oral)

#0040 #0042

#0083 #0092

HNES

(Oral)

#0040 #0046

HTSM

(Oral)

#0136 #0138

IBSS (Poster)

#0044 #0056

#0057 #0072

HNES(Poster)

#0028 #0029 #0031 #0033

#0041 #0043 #0047

12:10-13:20 Lunch Time

13:20-14:40


HTSM

(Oral)

#0036 #0053

#0077

ICEL

(Oral)

#0027 #0036

#0044 #0109

IBSS

(Oral)

#0037 #0051

#0067 #0113

ICESA

(Poster)

#0029 #0032 #0034 #0037

#0043 #0045 #0046 #0058

#0060 #0061


15:00-16:20


HTSM

(Oral)

#0044 #0065

#0079

ICEL

(Oral)

#0068 #0070

#0072

IBSS

(Oral)

#0052 #0054

#0070 #0077

HTSM (Poster)

#0049 #0057 #0071

#0101 #0104 #0145

ICEL (Poster)

#0043 #0049 #0064

#0088 #0090 #0096

#0101 #0102 #0104


16:40-18:00


HTSM

(Oral)

#0099 #0118

#0132

ICEL

(Oral)

#0071 #0094

#0107

ICESA

(Oral)

#0063 #0070

#0071

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Conference Schedule

August 30, 2019 (Friday)


Time

Room

Event

(Session) A (Session) B (Session) C

09:00-16:00 Check In

09:30-10:50

A5 B5 C5

HTSM

(Oral)

#0066 #0102

#0106 #0125

ICESA

(Oral)

#0055 #0057

#0062 #0069

IBSS

(Oral)

#0036 #0042

#0060 #0074


11:10-12:30

A6 B6 C6

HTSM

(Oral)

#0001 #0085

#0087 #0088

ICEL

(Oral)

#0065 #0082

#0086 #0093

IBSS

(Oral)

#0048 #0068

#0076 #0079 #0082

12:30-13:20 Lunch Time

13:20-14:40

A7 B7 C7

HTSM

(Oral)

#0069 #0121

#0141 #0149

ICEL

(Oral)

#0054 #0061

#0062 #0069

IBSS

(Oral)

#0062 #0063

#0088 #0091


15:00-16:20

A8 B8 C8

HTSM

(Oral)

#0123 #0134

#0137 #0140

ICEL

(Oral)

#0038 #0046

#0078 #0089

IBSS

(Oral)

#0083 #0098

#0110 #0105

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Conference Floor Map

2F

3F

Sakura (east)

A B C

1

2

3

4

International Committee

Meeting

ICESA 2019


August 28-30, 2019

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Guidelines for Presenting Authors and Session Chairs

Presentations are brief discussions of a focused topic delivered to a group of listeners in order to

impart knowledge or to stimulate discussion. Begin your presentation by telling your audience what

your topic is and what you will be covering. A notebook is equipped with an LCD projector for every

session room. Each speaker must bring his/her own USB memory stick for transferring the file(s) to

the notebook setup at each session. No overhead projectors will be provided. Please arrive at your

session early so that you have time to test the connection to the projector and know the session chair

and colleagues going to present at this session. Visual aids (such as maps, photos, film clips, graphs,

diagrams, and charts) can enrich and enhance the effectiveness of a presentation.

During the presentation, the Session Chair’s role is to coordinate the smooth running of the

session. Please begin and end the session on time. The order of presentations are printed in the session

program. If a speaker cancels or does not show up, the original time schedule should be adhered to

rather sliding every talk forward. As a session chair, please check the session program before you start

chairing the session. In case that one of your session’s speakers cancels at the very last minute, you

might have available a short talk of your own to help maintain the continuity of the session. Each

session normally contains 80 minutes, with the time per presentation determined by the number of

papers in the session. Equal time should be given to each paper. A well-prepared Session Chair can

help ensure that the speakers give high quality, trouble-free talks and that the audience appreciates the

entire session.

Finally, thank you for your participation and contribution to the conference.

ICESA 2019


August 28-30, 2019

13

ICESA_0063

Electro-magnetic smart cement/concrete based on desired electromagnetic transport through

structure

Viren vasava k, Pandit Deendayal Petroleum University, India

Shrey patel, Pandit Deendayal Petroleum University, India

ICESA_0070

River Flow Analysis and Implications in Water Resource Management and Policy Design

Michel Soto Chalhoub, Notre Dame University, Lebanon

ICESA_0071

Challenges in Marine Environmental Management – A Call for Scientific Innovation in Fighting

Plastic Pollution

Michel Soto Chalhoub, Notre Dame University, Lebanon

Session: C4 16:40-18:00 | 29-Aug-2019 Meeting Room C4

Session Chair: Dr. Kassem Saleh. ICESA

ICESA 2019


August 28-30, 2019

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ICESA_0063

Electro-magnetic smart cement/concrete based on desired

electromagnetic transport through structure

viren vasava k, shrey patel*

Civil Engineering, Pandit Deendayal Petroleum University,

Raisan,gandhinagar, gandhinagar, India

*Corresponding Author: [email protected]

Abstract

Magnetic concrete is a magnetic permeable concrete. Application of magnetic permeable concrete is

to get an optimum electromagnetic signals in mobile, Wi-Fi or any other devices in which

electromagnetic radiation is used. To achieve an optimum mix design of concrete at which proportion

we can get a desired electromagnetic signals. To reduce environmental pollution of radiation and

minimize the energy loss. Addition of ferromagnetic agents in concrete.as a ferromagnetic agent using

of iron content with different percentage and found out optimum mix design at which we get optimum

radiation measured by electromagnetic radiation tester in terms of micro tesla unit and using of

experiment measurement of magnetic field along axis. research work focus on safe radiation. As a

Ferromagnetic doping agents using of Iron scrap powder. It works as a smart concrete. It is a mixture

of cement, iron scrap powder, sand and PVA fibers. If structure constructed by magnetic concrete, then

it is easy to inspect reinforcement which covered under a concrete and forecasting structure life and

other strength analysis of structure. Reduction of environmental radiation pollution in highly intense

radiation zone and Increase the influence of electrical transport with the use of ferromagnetic agents

and minimize the energy loss. This research is focused on developing a doped ferromagnetic

engineered cementitious composite capable of efficient electromagnetic permittivity.

Keyword: Smart concrete, Magnetic permeability, Desired Electromagnetic signals, Ferromagnetic

agents

ICESA 2019


August 28-30, 2019

15

ICESA_0070

River Flow Analysis and Implications in Water Resource Management

and Policy Design

Michel Soto Chalhoub*

Civil and Environmental Engineering, Notre Dame University, Louaize, Zouk Mosbeh, Lebanon


Abstract

Several decisions related to public policies in sustainable development depend on engineering analysis

and the fluid mechanics of surface and ground water. Engineering analysis methodologies have a

notable impact on predictions of quantities of water and the timing of its availability, and therefore on

public policy decisions. We direct our attention to seasonal watercourses which are refuges to

ecosystems typically meandering and traversing inhabited rural areas. A mathematical model is

presented for fluid flow parameters proposing a modification to classical open channel methods. The

necessity of this modification is due to frequent river bents extending into weedy catchment basins.

We termed it “hybrid method” because it combines formulation with simplified field measurement to

adjust flow parameters. It is shown that the hybrid method provides improved results that are closer to

real life fluid flow behavior. Simplified cross-sectional shapes can be used for human-made canals but

natural watercourse sections are a complex function of location along the river, and vary in time due

to erosion and sediment transport. The relationship between the present results and policy decisions is

illustrated with a linear regression using data collected from seasonal watercourses in the East

Mediterranean. A dependent variable was formulated in a previous research stage to represent end-

user willingness to engage in sustainable development projects related to local surface water resources.

Four independent variables were defined as the extent to which engineering outcomes serve as a basis

for public policy decision; local surface water could meet household demand; local surface water could

meet irrigation and agricultural demand; and water resource project management entrusted to local

governing bodies. Results showed a statistically significant correlation with the four variables, while

it is positive for the first and third, and negative for the second and fourth. This relationship justifies

future research to extend into a cross-sectional analysis of seasonal watercourses to better harness

surface water resources in rural areas.

Keyword: Fluid mechanics, seasonal rivers, Watercourses, Sustainable planning, Public policy and

local community, Water resource management.

ICESA 2019


August 28-30, 2019

16

ICESA_0071

Challenges in Marine Environmental Management – A Call for

Scientific Innovation in Fighting Plastic Pollution

Michel Soto Chalhoub*

Civil and Environmental Engineering, Notre Dame University, Louaize, Zouk Mosbeh, Lebanon


Abstract

Marine plastic pollution is increasingly causing concerns related to ecosystems and human health. We

address plastic pollution in the East Mediterranean, discuss the lack of public policies, and provide

recommendations to be implemented hand-in-hand with the private sector. Empirical data collected on

the East Mediterranean shore is used to explore the extent of damage in the marine environment. It is

shown that remedial actions and preventive measures need to be managed in parallel with local

government and local communities. Secondary data show that plastic pollution is a regional problem

because it is transported by waves and currents. A linear regression model was developed to gauge

public attitudes in Lebanon, with dependent variable, Y, representing readiness of local communities

to fight plastic pollution. The independent variables were defined as (X1) the establishment of national

policies specific to plastic littering, (X2) incentives for sorting at the household level, (X3) developing

collaborative treaties at a regional level, and (X4) engineering innovation and advocacy to transition

into a plastic-free end-use. A statistically significant and positive correlation was found with the first

and fourth variables, but a negative correlation with the second. It is important to introduce innovative

products such as bio-degradable substitutes, and innovative processes such as plastic-to-fuel. Pollution

in the Mediterranean is a shared environmental cause that requires cross-border cooperation but

respondents were skeptical about prospects of regional collaboration or long term strategies. It is

recommended to sponsor engineering innovation research, and cross-border communities of experts

and policy-makers to overcome barriers to collaborative environmental preservation.

Keyword: Plastic pollution, Mediterranean, Regional environmental collaboration,

Policydevelopment, private sector advocacy.

ICESA 2019


August 28-30, 2019

17

ICESA_0055

Building a Quality-based Risk Management Taxonomy for Information Systems Development

and Management

Kassem Saleh, Kuwait University, Kuwait

ICESA_0057

Modeling and Analysis of System Risk Exposure Using the Petri Net Model

Mansour Jaragh, Kuwait University, Kuwai

Kassem Saleh, Kuwait University, Kuwait

ICESA_0062

Numerical Simulation of Droplet Drying and Solute Precipitation

Chih-Ang Chung, National Central University, Taiwan

Bo-Hsuang Wu, National Central University, Taiwan

ICESA_0069

Response Delay Improvement of Following Vehicle Prototype

Yun-Shuai Yu, National Formosa University, Taiwan

Session: B5 09:30-10:50 | 30-Aug-2019 Meeting Room B

Session Chair: Dr. Mansour Jaragh ICESA

ICESA 2019


August 28-30, 2019

18

ICESA_0055

Building a Quality-based Risk Management Taxonomy for

Information Systems Development and Management

Kassem saleh*

Information Sciences, Kuwait University, Kuwait


Abstract

The proper dealing with quality and risks is critical for a executing a successful information system (IS) development project or for the ongoing operation and evolution of an IS. However, both quality and risks are strongly intertwined and have to be considered in tandem. Earlier for example, the word risk did not even appear in the ISO 9001 standard on quality. Only in the recent revision of the standard, an emphasis on risk considerations was added. In a study on the assessment of project management maturity, both quality and risk management in the information systems industry had the lowest maturity scores of, 2.88 and 2.75 out of 5, respectively, among the various project management knowledge areas and among the four industries, including information systems, considered in the study. This shows clearly that there is room for improvements to be made in both the quality and risk domains of information systems project management. We can argue that having low maturity in risk management is a significant contributor to the low maturity in quality management. The improper considerations of risks would definitely affect the quality of the delivered product, in addition to affecting the other three project success criteria related to schedule, budget and scope. In this paper, we show how quality and risks in information system development and evolution are related leading us to develop a quality-based risk taxonomy and risk breakdown structure that can be used as a generic tool to identify risks while developing or managing an information system and its risks.

Keyword: Information Systems, Quality Management, Risk Management, Risk Taxonomy

ICESA 2019


August 28-30, 2019

19

ICESA_0057

Modeling and Analysis of System Risk Exposure Using the Petri Net

Model

Mansour jaragh2, Kassem saleh1*

1Information Sciences, Kuwait University, Kuwait

2computer engineering, Kuwait University, Kuwait


Abstract

Petri nets are used to model system operations and workflows. They are able to model both sequential

and concurrent behaviors of systems and their associated mathematical formulations are useful to

quantitatively analyze the model. The overall system behavior can be described and analyzed by

generating a reachability graph whose nodes are the steady states that the system goes through. The

basic Petri net model can be used and extended to model and quantitatively analyze various qualities

of a system such as time performance and risks. In this paper, we augment the Petri net-based model

with risk information associated with both places and transitions of the net. This information includes

the risk exposure representing the risk likelihood and risk impact related to the specific place or

transition. The model can then be analyzed to compute the overall system risk exposure and the

exposure at each steady state of the generated system reachability graph.

Keyword: Petri net, Reachability, Risk exposure, Risk management

ICESA 2019


August 28-30, 2019

20

ICESA_0062

Numerical Simulation of Droplet Drying and Solute Precipitation

Chih-Ang Chung*, Bo-Hsuang Wu

National Central University, Zhongda Rd, Taoyuan City, Taiwan


Abstract

Functional powders can have complicated structures. Important applications of functional powders

include, but not limited to, the pharmaceutical particles such as oral tablets and capsules and inhaled

aerosols through the nose into the lung. Functional powders can be manufactured using spray drying.

The powders in spray drying are formed in a heated reactor where a solution of precursors is atomized

to form droplets. The solvent in the droplet then evaporate and the solutes are left to form the product

powder. Experiments show that the particle structure is influenced by the relative ratio of droplet

evaporation rate and solute diffusion and precipitation rate. The final powder may appear as solid,

hollow spheres, or even bucking and crumpling shells. The droplet evaporation and solute precipitation

is a coupled heat and mass transfer problem. The entire drying process comprises four stages:

temperature adjustment, constant-temperature evaporation, solid crust formation, and solid shell

thickening. Each of the drying stages has been modeled, respectively. However, a comprehensive

model that can describe the whole process from the very beginning of droplet evaporation to the end

of particle formation is still developing. This paper is aimed to develop a fully comprehended model

that can include all of the four different stages using the same set of equations. The formation of solid

and hollow particles from solute precipitation of a liquid droplet was then investigated by a simulative

approach. The simulation model describes the evolution of the solute concentration, temperature

gradient, as well as size change of the droplet. The model also accounts for the vapor concentration

and temperature gradient in the ambient gas. The volume of fluid method (VOF) was adopted to

capture the liquid-gas interface. The entire drying process was analyzed using a sodium chloride

aqueous solution droplet as an example. Influence of ambient temperature on the final structure of the

precipitate particle was studied. Two distinct particle structures have been discussed. The droplet

solidifies into a solid particle when the ambient temperature is low, while a hollow sphere when the

ambient temperature is high. The mechanisms underlying these two particle structures are discussed.

Keyword: Droplet drying, Function powder, Solute precipitation, Volume of Fluid Method

ICESA 2019


August 28-30, 2019

21

ICESA_0069

Response Delay Improvement of Following Vehicle Prototype

Yun-Shuai Yu*

Department of Computer Science and Information Engineering,

National Formosa University, Yunlin County, Taiwan


Abstract

Following vehicles is an emerging technology that can facilitate people to walk without carrying heavy

things in their hands. In our previous work, we have developed a following vehicle prototype using

Robot Operating System, ROS, which is the most popular software framework for the development of

robots, including wheeled robots. The adoption of ROS is for the control of the movement of our

wheeled robot. In addition, the person who is being followed by our prototype has to carry a lightweight

radio transmitter which could be a smartphone or a wearable electronic device. Our prototype estimates

the distance between itself and its user based on the power present in received radio signals from the

radio transmitter. Weak signals mean the user is far away from our prototype so it should move forward.

On the contrary, strong signals cause the prototype to stop for the avoidance of collision. The

preliminary experimental results show that the prototype can correctly follow the movement of its user

in a linear direction but the response delay is obvious.

In this study, we analyzed the relationship between the delay and our software components. First, we

found that the sleeping period between consecutive operations for distance estimation is originally set

as 1000ms. This period enables the user to shut down the following functionality of the proposed

prototype. However, the long idle period leads to unnecessary response delay. Second, the sleeping

period between two consecutive ROS messages sent by our software components is also set as 1000ms.

Without the sleeping period, the underlying ROS can’t deliver any ROS messages between its

processes. Nevertheless, the sleeping period is still too long. As a consequence, both the sleeping

periods are set as 100ms in the current study and the response delay is reduced. It is worth noting that

the response delay sometimes increases a lot. We inferred that the reason may be due to multipath

fading. In the future, we are planning to apply a machine learning algorithm to achieve more accurate

distance estimations.

Keyword

Keyword: ROS, Robot, Following Vehicle, Delay

ICESA 2019


August 28-30, 2019

22

ICESA_0029

Fuzzy Decision Modeling for A Closed-loop Supply Chain with Asymmetric Information

Shih-Pin Chen, National Chung Cheng University, Taiwan

ICESA_0032

Optimization of the insecticidal activity of Photorhabdus luminescens 0805-P2R fermentation

conditions on Plutella xylostella

Chienyan Hsieh, National Kaohsiung Normal University, Taiwan

Yu-Ting Wang, National Kaohsiung Normal University, Taiwan

Hui-liang Wang, National Kaohsiung Normal University, Taiwan

Li-Hsin Wu, National Pingtung University of Science and Technology, Taiwan

Feng-Chia Hsieh, Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taiwan

ICESA_0034

Gallic Acid from Mangroves as potent sPLA2 inhibitory compound: Binding Studies

Tanvira Paul, VIT University, India

Dr. R. Seenivasan, VIT University, India

ICESA_0037

A Collusive Cheating Method for Visual Cryptography Schemes

Kai-Hui Lee, Ming Chuan University, Taiwan

Pei-Ling Chiu, Ming Chuan University, Taiwan

ICESA_0043

A Formal Description Method of Asynchronous Event Sequences Using Shuffle Expressions

Shinya Abe, Tokyo Metropolitan Industrial Technology Research Institute, Japan

Session: Room Sakura (east) 2 13:20-14:40 | 30-Aug-2019 Meeting Room Sakura (east) 2

Poster: ICESA

ICESA 2019


August 28-30, 2019

23

ICESA_0045

An intelligent wearable biosensor for blood pressure prediction based on photoplethysmography

Chia-Wei Chen, National Yang Ming University, Taiwan

Ching-Fu Wang, National Yang Ming University, Taiwan

Bo-Wei Chen, National Yang Ming University, Taiwan

Ssu-Ju Li, National Yang Ming University, Taiwan

Chin Chou, National Yang Ming University, Taiwan

You-Yin Chen, National Yang Ming University, Taiwan

ICESA_0046

Low-Complexity Beam Selection for Massive MIMO Systems

I-kuang Chen, National United University, Taiwan

Tsui-Tsai Lin, National United University, Taiwan

ICESA_0058

Uptake and Accumulation of Maize、Vetiver and Physic Nut for PCDD/Fs-contaminated Soil

Yu-Ming Wu, Cheng Shiu University, Taiwan

Shan-Mei Chen, Cheng Shiu University, Taiwan

ICESA_0060

Self-Assembled Activin A- and Bone Morphogenetic Protein 4-Grafted Poly(vinyl alcohol)-

Alginate-Gelatin Hydrogel with Retinoic AcidLoaded Solid Lipid Nanoparticles for Pancreatic

Differentiation of iPS Cells

Yung-Chih Kuo, National Chung Cheng University, Taiwan

I-Hsuan Lee, National Chung Cheng University, Taiwan

Rajendiran Rajesh, National Chung Cheng University, Taiwan

ICESA_0061

Apolipoprotein E-Conjugated Phosphatidic Acid-Liposomes with Encapsulated Quercetin- and

Rosmarinic Acid against Phosphorylation of Mitogen-Activated Protein Kinases In Vivo

Yung-Chih Kuo, National Chung Cheng University, Taiwan

Yung-I Lou, Providence University, Taiwan

Rajendiran Rajesh, National Chung Cheng University, Taiwan

Session: Room Sakura (east) 2 13:20-14:40 | 30-Aug-2019 Meeting Room Sakura (east) 2

Poster: ICESA

ICESA 2019


August 28-30, 2019

24

ICESA_0029

Fuzzy Decision Modeling for a Closed-loop Supply Chain with

Asymmetric Information

Shih-Pin Chen*

Department of Business Administration, National Chung Cheng University,

Ming-Hsiung, Chia-Yi, Taiwan


Abstract

This paper investigates decision-making in a closed-loop supply chain (CLSC) under information

asymmetry between SC members, in which the asymmetric information is described by fuzzy sets.

The proposed analysis method is based on Zadeh’s extension principle in fuzzy theory and

optimization theory. The problem is first formulated as a fuzzy optimization model with several fuzzy

parameters. To conserve the fuzziness of the asymmetric information of the supply chain, a pair of

two-level mathematical programs is proposed to identify the lower and upper bounds of the fuzzy

performance at different possibility levels so that the complete membership function can be described.

Notably, this paper devises an analysis method to provide a likely interval of the fuzzy maximal profit

with a known possibility level rather than a singleton. Several example scenarios are solved to

demonstrate the validity of the proposed analysis method. In addition, the managerial implications and

insights are also assessed and discussed via analytical and numerical results for reference by decision-

makers.

Keyword: Closed-loop Supply Chain, Extension Principle, Fuzzy Set Theory, Game Theory,

Information Asymmetry

ICESA 2019


August 28-30, 2019

25

ICESA_0032

Optimization of the insecticidal activity of Photorhabdus luminescens

0805-P2R fermentation conditions on Plutella xylostella

Chienyan Hsieh1*, Yu-Ting Wang1, Hui-liang Wang1, Li-Hsin Wu2, Feng-Chia Hsieh3

1Department of Biotechnology,

National Kaohsiung Normal University, Taiwan 2Department of Plant Medicine,

National Pingtung University of Science and Technology, Taiwan 3Biopesticides Division,

Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taiwan


Abstract

Photorhabdus luminescens is an entomopathogenic gram-negative rod-shaped bacterium isolated from

luminescent insects that have been infected by the insect nematode of the Heterorhabditidae. It was

was observed to kill insects by secreting high molecular weight toxin complexes. In this study, a third-

instar Plutella xylostella larva was orally administered for bioassay. In the LB medium, the cell

concentration reached the highest at 20 hours, and the cell concentration decreased as the culture time

increased, while the insecticidal activity increased. It was observed that the main insecticidal active

factor, in addition to the bacteria itself, the insecticidal active substance in the supernatant was also

confirmed to be larger than 210 kDa. After 20 hours of incubation with LB, the mortality to P.

xylostella from the fermentation broth with diluted 50 times and the supernatant with 5 times diluted

were 18.89%, and 91.11%, respectively. The 88% mortality was found in the retentates with larger

than 21KDa after UF membrane treatment. It shows that the supernatant of P. luminescens has

insecticidal activity, and the main insecticidal toxin complexes were found with a molecular weight

greater than 210kDa. Using L9(34) Taguchi orthogonal experimental design, the optimal medium for

insecticidal activity was studied factors included nitrogen source (A), carbon source (B), dissolved

oxygen (C), and cultivation time (D). After response analysis, the optimum conditions for the

insecticidal fermentation broth were A3B2C3D2, while the optimum conditions for the insecticidal

supernatant were A2B2C3D2. The mode-predicted insecticidal activity was 84% of the 50-fold diluted

fermentation broth obtained from the A3B2C3D2, and the 5-fold diluted supernatant was 109.6%. The

experimental results of insecticidal activity were improved by using A3B2C3D2, with the 100-fold

diluted fermentation broth being 92.2% and the 10-fold diluted supernatant being 97.8%.

Keyword: Photorhabdus luminescens, Plutella xylostella, insecticidal activity

ICESA 2019


August 28-30, 2019

26

ICESA_0034

Gallic Acid from Mangroves as potent sPLA2 inhibitory compound:

Binding Studies

Tanvira Paul1, Dr. R. Seenivasan2*

1Department of Biotechnology, VIT University, Vellore, Tamil Nadu, India 2Center for Nanobiotechnology, VIT University, Vellore, Tamil Nadu, India


Abstract

Secretory phospholipase A2 (sPLA2) is one of the major enzyme components of animal venom and is

also the first enzyme in the pro-inflammatory pathway. This enzyme is deeply associated with the

inflammatory processes of several conditions like atherosclerosis, rheumatoid arthritis, respiratory

distress symptom etc. However, the most commonly used non-steroidal anti-inflammatory drugs that

are used for treatment purposes are associated with severe side effects like gastrointestinal ulceration,

cardiovascular complications, bleeding etc. As such selective inhibition of sPLA2 enzyme is an

important criterion for a potent anti-inflammatory drug, which is why, inhibition mediated by bioactive

compound(s) are becoming a lucrative field of research owing to its potential in the drug development

process. In this current study, Acanthus ilicifolius L. (roots) and Lumnitzera racemosa Willd. (leaves),

mangrove plant species were collected, based on literature survey and folkloric use of these plant

extracts (for the treatment of snake, bee and wasp bites), in order to investigate and unravel their

unexplored anti-inflammatory potential. Aqueous plant extracts were prepared and tested for bee

venom sPLA2 inhibition studies by the agarose egg yolk plate method and the leaf extracts were found

to exhibit about 80% inhibition at 1:20 (w/w) ratio of sPLA2 : Plant extract. The UHPLC MS/MS

analysis aided us in identifying and constructing a library of bioactive compounds found in these

extracts. This eventually helped us select, gallic acid [GA] (bio-mining information-based selection)

for inhibition and interaction/binding studies by optical spectrometry and molecular dynamics

simulation. GA at a concentration ratio of 1:20μM exhibited 98% inhibition of sPLA 2. UV-Vis,

fluorescence spectroscopy and circular dichroism studies revealed about the binding and simultaneous

formation of a sPLA2-GA complex. This complex formation is responsible for the secondary and

tertiary structural alterations that ultimately leads to sPLA2 inhibition. Finally, the in silico molecular

docking and molecular dynamics simulation studies further substantiated the results obtained in our in

vitro experiments and provided evidence that GA is capable of efficiently inhibiting sPLA2 (binding

affinity of 5.29kcal/mol and formation of eight hydrogen bonds). Moreover, in the MDS system, the

complex formed showed proper convergence with less deviation from the starting structure (near to

0.35nm) throughout the 25ns simulations after GA binding. These results cumulatively proved that

sPLA2-GA complex remains stable in the dynamic system and efficiently inhibits sPLA2. Hence, GA

holds great potential to serve as a lead molecule for the development of more specific and potent

inhibitor molecules.

Keyword: Secretory phospholipase A2 (sPLA2) , Bee venom, gallic acid (GA), Antiinflammatory,

mangroves

ICESA 2019


August 28-30, 2019

27

ICESA_0037

A Collusive Cheating Method for Visual Cryptography Schemes

Kai-Hui Lee1, Pei-Ling Chiu2*

1Dept. of Computer Science & Information Engineering, Ming Chuan University, Taiwan 2Dept. of Risk Management & Insurance, Ming Chuan University, Taiwan


Abstract

The visual cryptography scheme (VCS) allows dealer shares a secret image by encrypting it as n shares

and distributes the shares to n different participants. The VCSs are proved a secure method for sharing

secret images. However, the noise-like shares cannot be identified by the participants, such that the

honest participants will suffer collusive cheating from malicious participants. In a (k,n)-VCS, when k

(malicious) participants stacked their shares and got the secret image, the k-1 participants can alter

their shares to cheat an honest participant (i.e., the k+1 participant). As k-1 fake shares and the honest

participant’s share were stacked, a fake secret image is revealed. Previous researches pointed out some

cheating methods that may be fail to cheat the honest participants successfully due to the malicious

participants need to know more details related to the VCS. In this study, we develop a collusive

cheating method that the cheaters don’t need to know the encryption details of the VCS. The proposed

method aims to make cheating in size invariant (k,n)-VCSs (or probabilistic VCSs). In this study, the

basic assumptions about the collusive cheating method include: the blackness level of each share are

equal, images by stacking any r shares (2<=r=k, has the same blackness level (B2) and contrast. The

collusive cheating problem is formulated as a mathematic optimization model subject to obey above-

mentioned conditions B1 and B2. The objective of the model is to maximize the contrast of the fake

secret image. We use an optimizer (i.e., CPLEX) to solve the model. Fig. 1 shows an experimental

result of the proposed method. The experimental results indicate that the proposed method can make

cheating successfully.

Keyword: Threshold visual cryptography scheme, Pixel expansion, Collusive cheating

ICESA 2019


August 28-30, 2019

28

ICESA_0043

A Formal Description Method of Asynchronous Event Sequences Using

Shuffle Expressions

Shinya Abe*

Tokyo Metropolitan Industrial Technology Research Institute, Japan


Abstract

In system operations testing, it is important to determine whether event sequences generated at runtime

are those intended by the developers. Automated testing is desirable but it requires developers to

formally describe rules for event sequences. Regular expressions are generally used to describe event

sequences because they allow easy descriptions and facilitate analysis using test automation tools.

However, regular expressions are known to have insufficient descriptive ability in systems where

events are asynchronously executed in parallel. For example, describing the operation of a semaphore-

based synchronization mechanism requires maintaining the current state; however, this is difficult

using regular expressions because they cannot store values. Regular expressions can describe

concurrency in an event sequence, but such expressions involve many sums and are thus not concise.

I therefore propose a description method for asynchronous event sequences using shuffle expressions

and provide description examples for typical asynchronous problems. This paper describes our method

and gives an example description for a web system that multiple users can access asynchronously and

concurrently access.

Keyword: Formal Description, Asynchronous Event Sequence, Shuffle Expression

ICESA 2019


August 28-30, 2019

29

ICESA_0045

An intelligent wearable biosensor for blood pressure prediction based

on photoplethysmography

Chia-Wei Chen, Ching-Fu Wang, Bo-Wei Chen, Ssu-Ju Li, Chin Chou, You-Yin Chen*

National Yang Ming University, Taiwan


Abstract

Blood pressure (BP) is one of the crucial vital signs for screening cardiovascular activity. In recent

studies, In order to estimate BP all the time from wearable device, photoplethysmography (PPG) and

electrocardiography (ECG) have become widely recognized as a low-cost non-invasive detection

technology for effectively estimating BP which has been recently studied improved by previous studies.

However, there are still some limitation with recording ECG and PPG simultaneously, such as

electrode of ECG connecting to both sides of the body, only awake status and without medical

regulation definition. Instead, all-day monitoring wearable device using only PPG-based wristbands

have been conducted as a convenient tool for healthcare. In order to estimate BP using PPG-based

wristbands for simpler design and more convenient user scenario. More advanced technique should be

implemented for intelligent wearable biosensor. The non-invasive optical blood pressure dynamic

monitor would estimate the characteristic of 15 sec PPG waveform, and using PPG morphology

characteristic, age and sexual to build up a database model, and using exponential Gaussian process

regression (GPR) model which is a kind of machine learning method to manage the long-term trend of

blood pressure. Combing the machine learning model and the personalized calibration method, the

results of the proposed algorithm are met by the Association for the Advancement of Medical

Instrumentation (AAMI) standard. Also, the dynamic BP variation has been validated as long-term BP

trend for clinical use.

Keyword: Blood pressure, Photoplethysmography, Machine learn, Wearable device

ICESA 2019


August 28-30, 2019

30

ICESA_0046

Low-Complexity Beam Selection for Massive MIMO Systems

I-kuang Chen, Tsui-Tsai Lin*

Department of Electronic Engineering, National United University,

No. 2 Lien-Da, Nan-hsih Li, Miaoli, Taiwan


Abstract

With the rapid growth of user equipment for mobile communications and the increase of diverse

multimedia service, heavy demand for mobile network traffic and spectrum resources is getting more

and more urgent. 5G technology is currently developed worldwide, which not only provides high data

transmission rate and excellent QoS but also supports fruitful internet-of-thing applications or

machine-type communications for device-to-device links. Millimeter wave (mmWave) massive

multiple-input multiple-out (MIMO) possesses the advantages of significantly increased data

transmission rate, higher spectrum efficiency, and larger spatial freedom, and has been recognized as

a major candidate for the air interface of 5G wireless communications. However, to realize massive

MIMO in mmWave frequencies confronts the rigorous challenges of unaffordable transceiver

complexity and energy consumption due to the requirement of a dedicated high-cost radio-frequency

chain for each antenna. As a remedy, the lens antenna array technique, which transforms the

transmitted signal in the spatial domain into the beamspace to enjoy the channel sparsity, has been

developed. To achieve the performance-complexity optimization, the beam selection is necessary to

determine an optimal set of the dominant beams with strong signal power using the feature of the

sparse beamspace channel. Nevertheless, most of existing schemes suffer from the problems of

prohibitive complexity and a poor trade-off between the sum-rate performance and energy efficiency.

In this paper, a low-complexity beam selection is proposed. The corresponding procedure is

summarized as follows: (1) Find the strongest beam for each user; (2) Determine the surviving beams

with power larger than a given threshold; (3) Perform the interference-aware (IA) beam selection for

the set of surviving beams. Computer simulations have been conducted to demonstrate that the

proposed beam selection can promise performance comparable to that of the optimal full system.

Furthermore, the performance of the proposed scheme is close to that of the conventional IA approach,

which requires a large amount of computational complexity.

Keyword: MmWave, Massive multiple-input multiple-output (MIMO), 5G, Beam selection.

ICESA 2019


August 28-30, 2019

31

ICESA_0058

Uptake and Accumulation of Maize、Vetiver and Physic Nut for

PCDD/Fs-contaminated Soil

YU-MING WU*, Shan-Mei Chen

Department of Food and Beverage Management,

Cheng Shiu University, Kaoshiung, Taiwan


Abstract

A greenhouse pot experiment was conducted to investigate the translocation and distribution of

PCDD/Fs in maize (Zea mays), vetiver (Vetiveria zizanioides) and physic nut (Jatropha curcas L.) and

the effect of plant root on microorganisms in the rhizosphere soil. The result showed three plants were

able to grow in the highconcentration of PCDD/Fs-contaminated soil. PCDD/Fs were detected in the

root and shoot of three plant after test, but roots took up most of the PCDD/Fs compared with shoots.

Due to the differences of plant species, the distribution of PCDD/Fs in the plant tissue was different.

The root of maize and the shoot of vetiver could absorb the highest concentrations. The root

bioconcentration factors (BAF) of PCDD/Fs was calculated and correlated with log Kow. The log Kow

values express the hydrophilic or hydrophobic of pollutants. PCDD/Fs congeners were taken up by the

roots of plant, and the translocation of PCDD/Fs to the shoot was inversely related to congeners

hydrophobicity. The high log Kow was a main factor that influence the uptake and translocate of

PCDD/Fs by plants. As the numbers of chlorine of PCDD/Fs increases, log BAF of plants were lower.

In our study, the most efficient plant species for the uptake of PCDD/Fs promoted the growth of the

highest number of total bacteria compared to the unplanted.

Keyword: Dioxin, Furan, Phytoremediation, Bioaccumulation

ICESA 2019


August 28-30, 2019

32

ICESA_0060

Self-Assembled Activin A- and Bone Morphogenetic Protein 4-Grafted

Poly(vinyl alcohol)-Alginate-Gelatin Hydrogel with Retinoic

AcidLoaded Solid Lipid Nanoparticles for Pancreatic Differentiation of

iPS Cells

Yung-Chih Kuo*, I-Hsuan Lee, Rajendiran Rajesh

Department of Chemical Engineering, National Chung Cheng University,

168, University Rd., Min-Hsiung, Chia-Yi, Taiwan


Abstract

A three-dimensional scaffold enables the formation of realistic tissue architecture and promotes

physiological responses to activate the differentiation of induced pluripotent cells (iPSCs) into

pancreatic islets. Poly(vinyl alcohol) (PVA), alginate (Alg) and gelatin (Gel) were conjugated with

methacrylic anhydride (MA) and were photo-crosslinked to prepare PVAMA-AlgMA-GelMA

hydrogel scaffolds using a water-in-oil self-assembly method. The swelling ratio, porosity and cell

entrapment in the hydrogel were investigated with various molar percentages of polymer matrix.

PVAMA and AlgMA assisted in improving the water content of the hydrogel, which created high

porosity for the migration of iPSCs, and GelMA enhanced the cell entrapment efficiency. The

selfassembled scaffolds with composition of PVAMA:AlgMA:GelMA = 1:1:2 were grafted with

activin A and bone morphogenic protein 4 (BMP4) to induce iPSCs to definitive endoderm (DE)

lineage, followed by treatment with retinoic acid-loaded solid lipid nanoparticles for controlled release

and guided differentiation of DE cells into insulinproducing cells. Flow cytometry analysis and

immunochemical staining evidenced that the scaffolds with crosslinked BMP4 boosted the role of

surface activin A at activin A:BMP4 = 3:1 in endodermal differentiation of iPSCs to produce the

highest level of insulin after pancreatic induction and glucose stimulation. The iPSC-laden PVAMA-

AlgMAGelMA hydrogel constructs composed of repeated units and modified with activin A and

BMP4 can be promising in generating pancreas-mimetic structure and supporting the functions of

pancreatic islets.

Keyword: Hydrogel Scaffold, Photo-Crosslinking, Induced Pluripotent Stem Cells, Activin A, Bone

Morphogenetic Protein 4

ICESA 2019


August 28-30, 2019

33

ICESA_0061

Apolipoprotein E-Conjugated Phosphatidic Acid-Liposomes with

Encapsulated Quercetin- and Rosmarinic Acid against

Phosphorylation of Mitogen-Activated Protein Kinases In Vivo

Yung-Chih Kuo1*, Yung-I Lou2, Rajendiran Rajesh1

1Department of Chemical Engineering, National Chung Cheng University,

168, University Rd., Min-Hsiung, Chia-Yi, Taiwan 2Department of Accounting, Providence University,

200, Taiwan Boulevard, Taichung, Taiwan


Abstract

An efficacious Alzheimer’s disease (AD) treatment modality requires combined pharmaceuticals in

specific drug delivery system. Quercetin (QUE) and rosmarinic acid (ROA) were loaded in

phosphatidic acid (PHA)-liposomes (LP) with surface apolipoprotein E (ApE), followed by covalent

crosslinking to activate biological pathways for penetrating the blood–brain barrier (BBB) and

redeeming the neuronal apoptosis from attack of β-amyloid1-42 (Aβ42) and neurofibrillary tangles.

Thin-film hydration method was utilized to prepare LP, followed by grafting with ApE, and

QUE/ROA-ApEPHA-LP was applied to AD Wistar rat model. The conjugation of LP with PHA

improved QUE and ROA activity against neurotoxicity of Aβ42. The fluorescent images of brain

capillaries revealed that surface modification with ApE improved the permeation ability of QUE/ROA-

ApE-PHA-LP across the BBB. In addition, the highest therapeutic efficacy was obtained in the case

of QUE/ROA-ApE-PHA-LP, compared to other QUE/ROA formulations studied in an in vivo AD

model. The cellular and molecular evidence from AD rats included the decrease in Aβ42 plaque

formation and interleukin-6 secretion, increase in the neuronal count in Nissl staining, and reduction

in the expression of phosphorylated JNK, ERK1/2, p38 kinase, S202 of tau protein and caspase-3. The

use of ApE-PHA-LP as a multiple-targeting formulation enhances QUE and ROA ability to infiltrate

the BBB, docks Aβ42 plaques and can be a potent approach to rescue degenerated neurons from AD.

Keyword: Liposome, Apolipoprotein, Mitogen-Activated Protein Kinase, Alzheimer’s Disease

ICESA 2019


August 28-30, 2019

34

Access to Conference Venue


Osaka International House Foundation is a public-service corporation founded by

Osaka City with permission from the Ministry of Foreign Affairs, with the purpose of

contributing to the internationalization of Japan. Based in Osaka, International House,

Osaka (i-house) acts as a focal point for international exchange activities within the

Kansai Region. By exploring the history, culture and other local aspects of Japan and

other countries the Foundation strives to help foster a mutual understanding and

friendship between citizens, and deepen relationships between Japan and other

countries of the world.

Website: http://www.ih-osaka.or.jp/english/

Address: 〒543-0001 2-6 Uehommachi 8-chome Tennoji-Ku, Osaka, 543-0001 Japan

Phone : +81 (6) 6773-8989

Fax : +81 (6) 6773-8421

http://www.ih-osaka.or.jp/english/

ICESA 2019


August 28-30, 2019

35

ICESA 2019


August 28-30, 2019

36

Access to International House, Osaka

*Subway:

[Tanimachi 9-chome Station] (Tanimachi and Sennichimae Lines) Exit No.3 or 5.

10minutes walk.

[Shitennoji-mae Yuhigaoka Station] (Tanimachi Line) Exit No.1 or 2.

10minutes walk.

*Kintetsu Railway

[Osaka-Uehommachi Station] 5minutes walk.

*City bus

[Uehommachi 8-chome Bus Stop] 1minutes walk.

ICESA 2019


August 28-30, 2019

37

Osaka City Route Map

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Documents

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