Society for 2050: What Science and Technology

Society for 2050: What Science and Technology

IARU-GSC Workshop Poster Presentations by GLAFS-UTokyo Students

Can Do to Build a Dynamic Aged Society

November 4, 2016

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Poster Presentations by GLAFS-UTokyo Students November 4, 2016

Ito Hall Event Space, B2F, Ito International Research Center 11:40-12:50 List of Poster Presentations

Number Presentation

Time Presenter Title

1 11:40-12:15 Community-based Action Research Group1 (Presenter: Nobutada Yokouchi)

Practice for supporting the decision-making of the persons with dementia: A field study of “Dementia cafe”

2 12:15-12:50 Community-based Action Research Group2 (Presenter: Ayako Baba)

Appropriate Allocation of Long Term Care Insurance (LTCI) Services for Home Care:Inquiries about the combination of services and related factors

3 11:40-12:15 Community-based Action Research Group3 (Presenter: Ryosuke Takada)

Actual conditions of falls in elderly Japanese living in single-family house: A qualitative study

4 12:15-12:50 Community-based Action Research Group4&5 (Presenters: Takayuki Hamada, Kazuki Kaneko)

Development of programs and facilitation techniques to build a community of healthy elderly

5 11:40-12:15 Community-based Action Research Group6 (Presenters: Ou Fu, Kazuma Kaito)

Dining style and residents’ meal satisfaction in senior care facility

6 12:15-12:50 Community-based Action Research Group7 (Presenters: Ningjia Yang, Shoma Arita, Taiyu Okatani, Keita Suzuki)

Needs assessments of support robots for seniors with mild physical and cognitive impairment

7 11:40-12:15 Ryota Mugiyama

Cumulative Disadvantage Process in Japan: Does Employment and Marital History Affect Income and Wealth Inequality among Elderly People?

8 12:15-12:50 Miho Ishimaru et al. Association between perioperative oral care and postoperative complications: a high-dimensional propensity score matched analysis

9 11:40-12:15 Kojiro Morita et al.

Association between dementia and reduction in discharge to home in nursing home residents: A retrospective cohort study using a nation-wide elderly care insurance claim database in Japan

10 12:15-12:50 Hiroshige Matsumoto The use of a socialization place by senior citizens in Japan

11 11:40-12:15 Mariko Sakka

The difference of demographic and psychological characteristics between working and non-working caregiver for an elderly person with dementia

12 12:15-12:50 Chie Fukui et al. Factors associated to family conflict for family caregivers of people with dementia in long-term care facilities

13 11:40-12:15 Fumika Horinuki Improving healthcare professionals' communication for supporting cancer patient

14 12:15-12:50 Ayako Ishii Effects of nursing aid use on patients' fall and nurses' overtime hours in Japanese acute care wards: A nationwide survey

15 11:40-12:15 Satomi Nukina

Self-management interventions to prevent exacerbations of Chronic Obstructive Pulmonary Disease and improve patients’quality of life: the role of home-care nursing in community-based care (Research Thesis)

16 12:15-12:50 Taichi Goto et al. Identifying a wound pain biomarker for non-communicative patients: applicability test of a pain evaluation method for rat wound model

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Li List of Poster Presentations (Continued)

Number Presentation Time Presenter Title

17 11:40-12:15 Nana Shinozaki

Dietary phosphorus intakes estimated by two 24-hour urine collections and by 4-day dietary records and their associated factors in Japanese adults

18 12:15-12:50 Aya Fujiwara Dietary fiber intake and the sources in the current Japanese diet

19 11:40-12:15 Yuri Kominami Developing a novel method to control fish meat texture inducing proteolysis in fish skeletal muscle

20 12:15-12:50 Hazuki Yoshinaga Study on fish lipid metabolism with future perspective of developing novel technology for controlling fish meat texture

21 11:40-12:15 Mio Doke et al. Progranulin is required for estrogen receptor α expression in astrocytes

22 12:15-12:50 Sakiko Taniguchi et al. The analysis of the hippocampal synaptic function of the senescence-accelerated mouse prone 8

23 11:40-12:15 Hisashi Moriizumi Feedback-modification of MKK4 leads to cell death

24 12:15-12:50 Sayaka Hirukawa Vaccine Strategy for The Elderly

25 11:40-12:15 Atsuhiko Yasuhara Characterization of the antigenic properties of influenza A(H1N1)pdm09 virus

26 12:15-12:50 Yoshiyuki Nakagawa Development of Smart Hydrogel Materials Applicable for 3D Tissue Construction via Bioprinting

27 11:40-12:15 Ren Komatsu

Free Viewpoint Image Generation for Robot Teleoperation in Indoor Environments Using Body Mounted Cameras and a Laser Rangefinder

28 12:15-12:50 Akihiro Kubota Navigation system for the minimally invasive surgery by compensating body motion

29 11:40-12:15 Emiko Uchiyama et al. Developing frailty evaluation system to prevent falls in daily lives from human motion: Preliminary examinations

30 12:15-12:50 Shujirou Imaeda Mechanism of falls in the elderly related with Architectural factors: A qualitative study

31 11:40-12:15 Kyoungmin Kim Geographical Factors in Siting Providers and Users of Home-visit and Day-care Services : Focusing on Service Area of the Facility Type

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #1 「Community-based Action Research Group 1」 11:40-12:15 Practice for supporting the decision-making of the persons with dementia: A field study of “Dementia cafe” Nobutada Yokouchi1, Fumika Horinuki2, Hiroko Okada3, Yuka Sumikawa4, Makoto Suto5, Chie Fukui6, Ryogo Ogino7, Park Hyosook7, Mahiro Fujisaki7, Satoko Nagata4, Norio Higuchi8, Jun Goto7 1 Department of Social Gerontology, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 2 Department of Gerontological Home Care and Long-term Care Nursing/ Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 3 Department of Health Communication, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 4 Department of Community Health Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 5 Lifelong Learning Infrastructure Management Course, Graduate School of Education, The University of Tokyo. 6 Department of Family Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 7 Institute of Gerontology, The University of Tokyo. 8 Graduate Schools for Law and Politics, Faculty of Law, The University of Tokyo. 【Background】Recently, there has been an increasing demand on the practice for supporting the decision-making of the persons with dementia, aiming to improve their well-beings. While “Dementia cafe” is considered as a place where the tacit knowledge is aggregated. 【Objective】The purpose of this study is to explore the practices exercised in “Dementia cafe” to empower the decision-makings of the persons with mild dementia. 【Methods】Participatory observation was conducted to observe the interaction among the persons with dementia, their families, and staffs in two cafes respectively. Further interviews on the family members and the staffs were conducted for triangulating the information regarding the practices being observed. 【Results】Several types of practices were explored as tentative results, while the most prevailing one is empowerment of the persons by their families and staffs.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #2 「Community-based Action Research Group 2」 12:15-12:50 Appropriate Allocation of Long Term Care Insurance (LTCI) Services for Home Care — Inquiries about the combination of services and related factors— Ayako Baba1, Akihiro Fujita2, Emiko Ando3, Mariko Sakka4, Maho Haseda45, Eunji Hwang6, Ryota Mugiyama6, Wang Tiantian7, Taiki Yoshino8, Gota Yamaguchi9, Kim Kyuwon10, Miho Ishimaru11, Yasutaka Fukui12, Mari Kimata12, Ikuko Sugawara12

1 Division of Clinical Psychology, Department of Integrated Education and Science, Graduate School of Education, The University of Tokyo. 2 Department of Urban Engineering, School of Engineering, The University of Tokyo. 3 Department of mental he alth, Graduate School of Medicine, The University of Tokyo. 4 Department of Family Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 5 Department of Health Education and Sociology, Graduate School of Medicine, The University of Tokyo. 6 Department of Sociology, Graduate School of Humanities and Sociology, The University of Tokyo. 7 Department of General Systems Studies, Graduate School of Arts and Sciences, The University of Tokyo. 8 Department of Social Psychology, Graduate School of Humanities and Sociology, The University of Tokyo. 9 Department of Precision Engineering, Graduate School of Engineering, The University of Tokyo. 10

Department of Precision Engineering, School of Engineering, The University of Tokyo. 11 Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo. 12 Institute of Gerontology, The University of Tokyo. The Japanese government has promoted an integrated community care system that provides long-term comprehensive care for older people. However, little is known about how to combine the various Long Term Care Insurance (LTCI) services together and what factors constrain users’decision-making. Therefore, this research was designed to identify combinations of services at each care level while focusing on four factors: health condition, family relationship, residential environment, and regional resources. Latent class analysis was used to analyze K city’s LTCI recipient data and questionnaire surveys. The following findings were indicated: (1) the number of combinations decreased when the level of care required is high; (2) selected combination patterns depended more on family relationships (especially with primary caregiver) than residential issues; (3) community-based service users tended to live in regions with sufficient services. These findings led us to a further study of older peoples’ decision-making processes relating to home care, despite inequalities in social networks.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #3 「Community-based Action Research Group 3」 11:40-12:15 Actual conditions of falls in elderly Japanese living in single-family house: A qualitative study Shujirou Imaeda1, Tomoki Tanaka2, Sakiko Taniguchi3, Emiko Uchiyama4, Hiroshige Matsumoto5, Kyoungmin Kim1, Mio Choki1, Ryosuke Takada1, Kojiro Morita5, Suthutvoravut Unyaporn2, Akiko Nishino7, Bo-Kyung Son7. 1 Department of Architecture, Graduate School of Engineering, The University of Tokyo. 2 Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo. 3

Department of Food and Physiological Models, Graduate School of Agricultural and Life Sciences, The University of Tokyo. 4 Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo. 5 Department of Community Health Nursing, Graduate School of Medicine, The University of Tokyo. 6 Department of Clinical Epidemiology & Health Economics, Graduate School of Medicine, The University of Tokyo. 7 Institute of Gerontology, The University of Tokyo. Aim: To identify the risk factors of falls and fall-related fractures in elderly adults living in the residential area depending on their architectural environment and physical condition. Setting: Suburban area in Aoba Ward, Yokohama City, Japan. Methods: To assess actual conditions of falls using by home-visit interview. Results: Ten elderly adults aged 67 to 98 (90% women) were participated in this study. Five of subjects experienced fall-related fracture, and 3 of them fell in their home, including the approach. Ten of 15 falls were caused with difference in level. Six of them were caused with missing a step on stairs. After an experience of falls, 3 subjects changed their living environment such as renovation of housing, moving and living together with their children. Taken together, it is considered that the injury degree when falling in their home was more severe compared to that when falling outside among subjects of this study. Conclusion: the actual location of falls and how the elderly fall were revealed and our results would be helpful to develop an intervention to prevent falls with architectural and physical approach.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #4 「Community-based Action Research Group 4/5」 12:15-12:50 Development of programs and facilitation techniques to build a community of healthy elderly Kazuki Kaneko1, Takayuki Hamada2, Shingo Yoshida3, Satomi Kikuoka4, Jang Hyewon 5, Mio Doke6, Makoto Suto7, Yaka Matsuda7, Yukitsugu Komazawa2, Takashi Miyabe5, Aya Fujiwara8, Unyaporn Suthutvoravut9, Rogie Royce Carandang10, Masayuki Anekawa11, Yoshifumi Kurata2, Ryogo Ogino12, Mari Kimata12, Takahiro Miura12, Jun Goto12. 1 Department of Precision Engineering, Graduate School of Engineering, the University of Tokyo. 2

Department of Urban Engineering, Graduate School of Engineering, The University of Tokyo. 3

Department of Agricultural and Resource Economics, Graduate School of Agricultural and Life Sciences, The University of Tokyo. 4 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo. 5 Department of Sociology, Graduate School of Humanities and Sociology, The University of Tokyo. 6 Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo. 7

Department of Integrated Education and Science, Graduate School of Education, The University of Tokyo. 8 Department of Social and Preventive Epidemiology, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. 9 Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo. 10 Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo. 11Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo. 12 Institute of Gerontology, The University of Tokyo. One of the challenges of a hyper-aged society is to provide opportunities for elderly active social participation. These activities are intended to prevent reduction in the overall Quality of Life, such as prevention of physical frailty and strengthening of social capital for life support. Building an autonomous group of people who shares the same hobbies and preferences are likely to influence elderly participation. Our aim is to develop programs and facilitation techniques that will encourage participation from those elderly people who secluded themselves from social activities. The study was conducted in a cross-sectoral approach targeting two districts. In Kashiwa city, Chiba, we developed facilitation methods to guide the elderly in starting up their own group through holding of movie screenings. We conducted a case study about an allotment in Okutama city, Tokyo, and revealed the elements necessary to make the group of elderly attractive and more sustainable.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #5 「Community-based Action Research Group 6」 11:40-12:15 Dining style and residents’ meal satisfaction in senior care facility Ou Fu1, Kazuma Kaito2, Unyaporn Suthutvoravut3, Sayaka Hirukawa4, Tomoki Tanaka3, Mai Takase5, Tsutomu Hashidume6, Mari Kimata6, Hiroshi Murayama6

1 Department of Applied Biochemistry, Graduate School of Agriculture and Life Science, The University of Tokyo. 2 Department of Chemical System Engineering, School of Engineering, The University of Tokyo. 3 Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo. 4 Department of Bacteriology, Graduate School of Frontier Science, The University of Tokyo. 5 Department of Aquatic Bioscience, Graduate School of Agriculture and Life Science, The University of Tokyo. 6 Institute of Gerontology, The University of Tokyo. Dining style (i.e., lonely eating and social dining) is a determinant of meal satisfaction. However, dining style of residents in senior care facility and their corresponding satisfaction remain unclear. The main focus of the group is to study senior dining and aim to achieve better dining condition. In this study, we aimed to assess actual dining styles among residents in assisted living facilities and explore factors related to these dining styles. Among 190 respondents for the questionnaire survey, approximately 13.7% felt lonely during their meals (February, 2016). They had higher risk of depression and lower diet-related QoL compared to those who did not feel lonely, despite dining style. Many of the interviewed residents (n=10) dined at cafeteria and engaged in social dining, but were generally unsatisfied with their dining condition. Primary reason was “fixation of seats”: the seats are not assigned, but naturally became semi-fixed over time. This research enlightening that some residents had negative feelings for their dining emphasized the necessity to tackle this.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #6 「Community-based Action Research Group 7」 12:15-12:50 Needs assessments of support robots for seniors with mild physical and cognitive impairment Ren Komatsu2, Nana Shinozaki1, Satomi Nukina1, Hisashi Moriizumi5, Atsuhito Yasuhara5, Ningjia Yang2, Mingzhen Zhang2, Kazuki Kaneko2, Akihiro Kubota2, Yoshiyuki Nakagawa2, Ziaratnia Sayyed Ali2, Hazuki Yoshinaga3, Mio Doke3, Taichi Goto1, Chand Krishant1, Ayako Ishii1, Yuka Sumikawa1, Yukihiro Tsuruta3, Taiyu Okatani4, Yuki Kinoshita4, Keita Suzuki4, Shoma Arita4, Yuri Kominami3, Rumiko Tsuchiya1, Takahiro Miura6, Akiko Nishino6, Atsushi Hiyama7, Katsuya Iijima6, Toshiaki Tanaka6, Junichiro Okata2,6

1 Graduate School of Medicine, The University of Tokyo. 2 Graduate School of Engineering, The University of Tokyo. 3 Graduate School of Agricultural and Life Sciences, The University of Tokyo. 4 Graduate School of Information Science and Technology, The University of Tokyo. 5 Graduate School of Frontier Science, The University of Tokyo. 6 Institute of Gerontology, The University of Tokyo. 7 Research Center for Advanced Science and Technology, The University of Tokyo. Various types of support robots are invented for supporting elderly people with severe impairments or frailties. However, it remains unclear the needs of robots for the healthy elderly with mild physical or cognitive impairment. By discovering the needs, which is our object in this study, we can make them accustomed to caregiving by robots at early stages of decline in their abilities. In this poster, we introduce our preliminary evaluation about communication robots, where we asked elderly participants to answer impressions. The scores on the system usability scale (SUS) and interview results indicate that mammal-like communication robots were more preferable to older age groups. Also, seniors with minor physical disorders tended to prefer automated robots. Our future work includes interview survey with a broader range of questions to unearth the potential needs, toward our ultimate goal of developing a guideline for robot creation for senior people at physical or cognitive ability decline.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #7 11:40-12:15 Cumulative Disadvantage Process in Japan: Does Employment and Marital History Affect Income and Wealth Inequality among Elderly People? Ryota Mugiyama

Department of Sociology, Graduate School of Humanities and Sociology, The University of Tokyo.

In Rapidly aging Japan, economic inequality among elderly people is important issue for well-being, but little is known about the processes of generating inequality among them. This presentation examined the impacts of early employment and marital history upon subsequent annual income from public pension and wealth in later life. Using recent retrospective social survey data in Japan, we find that older men who had engaged in white collar job or worked in large firm enjoy more income from public pension and accumulate wealth. Women who had widowed or divorced suffered lower income and wealth, but youth employment statuses are only weakly associated with their economic statuses.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #8 12:15-12:50 Association between perioperative oral care and postoperative complications: a high-dimensional propensity score matched analysis Miho Ishimaru, Sachiko Ono, Hiroki Matsui, Hideo Yasunaga Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan. Objective: The purpose of this study was to evaluate the association between perioperative oral care and postoperative pneumonia and other surgical complications after cancer resection. Methods: We identified patients who underwent cancer resections between 2014 and 2015 in a Japanese healthcare administrative claims database. The patients were divided into the groups with and without perioperative oral care. High-dimensional propensity score matching methods and conventional propensity score matching method were performed to balance patients’ characteristics between the groups. Chi-square test was performed to compare the occurrence of postoperative pneumonia and other surgical complications. Results: We identified 4995 eligible patients including 621 patients with perioperative oral care. The proportions of postoperative pneumonia and other surgical complications were not significantly different between the groups in either high dimensional propensity score or conventional propensity score matched analyses. Conclusions: The present study did not show a significant association between perioperative oral care and postoperative complications following cancer surgery.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #9 11:40-12:15 Association between dementia and reduction in discharge to home in nursing home residents: A retrospective cohort study using a nation-wide elderly care insurance claim database in Japan Kojiro Morita, RN, PHN, MPH, Sachiko Ono, Hideo Yasunaga, MD, PhD

Department of Clinical Epidemiology and Health Economics, School of Public Health, Graduate School of Medicine, The University of Tokyo. Purpose We investigated whether dementia was associated with reduction in discharge to home among nursing home residents in Japan. Methods Using a Japanese nation-wide elderly care insurance claim database, we identified 412,929 residents from 1,539 nursing homes between April 2012 and March 2014. Primary outcome was discharge to home. Multivariable competing-risks Cox regression was used with adjustment for residents’ characteristics and regional social economic status. Residents’ level of care needed and several medical conditions were time-varying covariates at monthly interval. Death, admission to hospital, or admission to other long term care facility were treated as competing risks. Results Overall, 87,419 residents (21.2%) experienced discharge to home during two-year follow-up. Twenty-nine percent of residents had dementia. In the multivariable analysis, dementia was significantly associated with reduction in discharge to home (adjusted cause-specific hazard ratio, 0.73; 95% CI, 0.70-0.76) Conclusion Only twenty-one percent of nursing home residents experienced discharge to home. Policy makers should improve the current supporting system for elderly residents with dementia to promote their discharge to home.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #10 12:15-12:50 The use of a socialization place by senior citizens in Japan Hiroshige Matsumoto

Department of Community Health Nursing, Graduate School of Medicine, The University of Tokyo. The present study examined how senior citizens use a socialization place (SP), a public space where senior citizens could socialize with other seniors without making prior appointments. Data were from participant observation over nine months at an SP in a suburban housing complex in Tokyo, in-depth formal and informal interviews (12 users, 6 staff), and related documents, which were analyzed qualitatively. Six styles of regular use emerged: Park, School, Library, Meeting-room, Shipping, and Event style. Frequency of SP use and the level of cohesion within the group were two properties that distinguished the six styles. The seniors rarely changed their style because each person’s physical condition and social background largely determined the use style. These pluralistic styles of SP use were influenced by the various features of the SP that allowed seniors with various conditions to use the facility.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #11 11:40-12:15 The difference of demographic and psychological characteristics between working and non-working caregiver for an elderly person with dementia Mariko SAKKA Department of Family Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. Objective: Providing care for an elderly person with dementia has been described as a stressful experience. Moreover, workers resigned from their company due to providing care for older parents with dementia. The aim of this study was to clarify the difference of demographic and psychological characteristics between working and non-working family caregiver who have an elderly person with dementia. Methods: I used baseline data of 48 working and 16 non-working family caregivers that were collected from longitudinal survey in Japan. Fisher’s exact tests and Welch’s t-tests were used to compare demographic and psychological characteristics between working and non-working family caregiver. Results: Caregiver’s age, contents of care, caregiver’s role strain, and the rate of primary caregiver are significantly different between working and non-working family caregiver. Conclusion: There are the differences of demographic and psychological characteristics between working and non-working family caregiver. Future research considers these characteristics to examine support for family caregiver.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #12 12:15-12:50 Factors associated to family conflict for family caregivers of people with dementia in long-term care facilities Chie Fukui, Mariko Sakka, Iori Sato, Kiyoko Kamibeppu

Department of Family Nursing, Graduate School of Medicine, school of Health Sciences and Nursing, The University of Tokyo. Purpose: The purpose of this study was to explore factors associated to family conflict for family caregivers of people with dementia in long-term care facilities (LTCF). Design and Methods: Individual interviews with 12 family caregivers of people with dementia in LTCF were conducted in 2015. The interviews were audiotaped, transcribed and analyzed. Results: Nine family caregivers recognized that there are some differences of opinion about caregiving among family members. Analyses revealed five categories; characteristics by family member, knowledge of caregiving, supports from family members to family caregiver, actions and attitudes toward family caregiver, actions and attitudes toward person with dementia. Conclusion: Family conflict was varied by the combination of factors associated to family conflict. It was suggested that staffs in LTCF multilaterally determine family conflict.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #13 11:40-12:15 Improving healthcare professionals’ communication for supporting cancer patients Fumika Horinuki, Noriko Yamamoto-Mitani Department of Gerontrogical Home Care and Long-term Care Nursing/ Palliative Care Nursing, Graduate School of Medicine, The University of Tokyo. Background: Knowledge about health communication from the perspective of cancer patients is limited. Master thesis: Qualitative, semi-structured interviews were conducted with 14 bereaved families of cancer patients. Data were analyzed using grounded theory to develop categories and assess the relationship among them. From the standpoint of the bereaved families, the patient’s experiencing ownership of one’s illness process enabled them to live to the fullest possible despite multiple constraints. Two approaches used by healthcare professionals (HCPs) in communication play a crucial part in this experiencing ownership of one’s illness process: acknowledging the patient’s way of life and letting the patient catch up with the disease. Doctoral thesis: I would like to re-evaluate health communication from the viewpoint of cancer patients and HCPs. I would also like to evaluate the relationship between HCPs’ communication and patient outcomes by qualitative interviews to cancer patients and HCPs and a longitudinal study based on a questionnaire survey and chart review of cancer patients.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #14 12:15-12:50 Effects of nursing aid use on patients’ fall and nurses’ overtime hours in Japanese acute care wards: A nationwide survey Ayako Ishii, Noriko Yamamoto-Mitani Department of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. The increase in older patients in Japanese acute care wards has led to an increase in licensed nurses’ workload. In Japan, the scope of nursing practice is rather unclear and there has been much discussion that nurses are spending time for jobs that could be covered by non-licensed workers. Nursing aids (NAs) might be used effectively for reducing nurses’ workload. However, it has been reported that NAs are underused due to the lack of standards for NAs’ work contents and necessary education, and little has been known on activities of NAs and their effect on healthcare quality. We conducted a cross-sectional questionnaire survey across Japan, aiming to clarify (1) NAs’ activities in the ward and education provided for them and (2) the association between the number of NAs and patients’ fall and nurses’ overtime hours. The results would help us explore effective use of NAs and needed education that may lead to improving the nurses’ work environment and patient care quality.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #15 11:40-12:15 Self-management interventions to prevent exacerbations of Chronic Obstructive Pulmonary Disease and improve patients’quality of life: the role of home-care nursing in community-based care Satomi Nukina, Noriko Yamamoto

Department of Gerontological Home Care and Long-term Care Nursing/ Palliative Care Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo. The number of patients with chronic obstructive pulmonary disease (COPD) has increased in Japan’s aging society. Exacerbations of COPD affect patients’ quality of life and are an economic burden to society. Although exacerbations can be prevented through self-management, a survey found that many patients did not practice self-management effectively because they lacked information. Home-care nursing might be able to support patients’ self-management behaviors by providing needed information. However, it is not clear how patients practice self-management and what support they receive, including home-care nursing. This study will clarify: (1) actual situations for which patients utilize medical and health-care services, (2) patients’ difficulties with self-management and (3) effective support from home-care nursing. To achieve these aims, we will (1) analyze data pertaining to health-care and long-term care insurance fees, (2) interview patients and healthcare professionals, and (3) conduct a cross-sectional survey to home-care nursing agencies.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #16 12:15-12:50 Identifying a wound pain biomarker for non-communicative patients: applicability test of a pain evaluation method for rat wound model Taichi Goto1,2, Gojiro Nakagami1, Takeo Minematsu1, Masamichi Shinoda3, Hiromi Sanada1 1 Department of Gerontological Nursing/ Wound Care Management, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. 2 Global Leadership Initiative for an Age-Friendly Society, The University of Tokyo Bunkyo-ku, Tokyo, Japan. 3 Department of Physiology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan. Cognitively impaired elderly patients with chronic wounds such as pressure injuries, diabetic foot ulcers, and venous leg ulcers, are sometimes non-communicative and unable to express their wound pain. Therefore, there is a need to identify a biomarker, using basic animal research, to aid in objective evaluation of wound pain and to provide appropriate care. However, a method to evaluate pain in the dorsal wound rat model, a common wound model, is yet to be determined. Therefore, establishing this method is the first step required. Here, we report results showing that the von Frey Test (VFT), a method of pain evaluation that involves observing the behavior towards a stimuli, was able to differentiate a less painful situation induced by morphine hydrochloride, and a painful situation induced by λ-carrageenan, from the respective control groups. These results suggest that the VFT can be applied for evaluation of wound pain. This study was approved by the Animal Research Committee of The University of Tokyo.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #17 11:40-12:15 Dietary phosphorus intakes estimated by two 24-hour urine collections and by 4-day dietary records and their associated factors in Japanese adults. Nana Shinozaki Graduate School of Medicine, The University of Tokyo Objectives: This cross-sectional study estimated dietary phosphorus intakes by 24-hour urine collections (UC) and by dietary records (DR) and examined their associated factors. Methods: 161 men and 163 women aged 20-69 years throughout Japan completed two-day UC and 4-day DR. For estimating dietary phosphorus intake by UC, the phosphorus absorption rate was assumed by a comprehensive literature review. Results: Phosphorus intake estimated by UC was higher than that estimated by DR (mean: 1393 vs 1176 mg for men; 1081 vs 1018 mg for women), although they were significantly correlated (r=0.29 for men, r=0.31 for women). Estimated dietary phosphorus intake by UC was positively associated with body mass index for both sexes and physical activity for women, and that by DR was positively associated with age in women. Conclusions: Despite the moderate correlation between estimated dietary phosphorus intake by UC and that by DR was demonstrated, their associations with age, body mass index, physical activity were different in Japanese adults.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #18 12:15-12:50 Dietary fiber intake and the sources in the current Japanese diet Aya Fujiwara Department of Social and Preventive Epidemiology, Graduate School of Medicine, The University of Tokyo

In an aged society, prevention of non-communicable diseases is required for extension of healthy life expectancy. Increasing dietary fiber intake reduces the incidence of non-communicable diseases such as cardiovascular disease and diabetes. National survey, however, suggested insufficient intake of dietary fiber in Japanese. To increase the intake effectively, the information of the dietary sources must be needed. In the present study, dietary fiber intake and the sources in the current Japanese diet were estimated by 4d diet records. Healthy men (n=196) and women (n=196) aged 20-69 years were recruited from twenty areas in Japan. Age was positively associated with dietary fiber intake and the sources differed between age categories. Therefore food groups recommended as the sources of dietary fiber should be set with consideration of the target generation. Contrary to the general expectance, dietary fiber intake from root vegetables was lower than other vegetables, and those from semi-refined cereals were much lower than refined cereals, predictively.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #19 11:40-12:15 Developing a novel method to control fish meat texture inducing proteolysis in fish skeletal muscle Yuri Kominami Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Many studies showed that fish intake is associated with increase of healthy life expectancy. Fish intake affects not only physiological or physical condition but also mental health or cognitive performance. A previous study showed that a diet high in fish and fish products is associated with better cognitive performance in a dose-dependent manner. However the risk of accidental deglutition increases with aging. Especially for many elderly people who have trouble in deglutition find it difficult to bite off fish meat and swallow them smoothly. This study focused on obtaining soft fish meat via inducing proteolysis artificially. The mechanism of proteolysis in fish skeletal muscle induced by acute stress will be explored. This study will contribute to develop a novel method to control cultured fish meat texture and it will lead to supply soft fish meat for elderly people.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #20 12:15-12:50 Study on fish lipid metabolism with future perspective of developing novel technology for controlling fish meat texture Hazuki Yoshinaga Laboratory of Marine Biochemistry, Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Fish meat is known to be beneficial for human health due to its high quality protein and functional components, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, fish meat can be difficult for with deglutition disorder to swallow and choking accidents are reported every year. Texture of fish meat is affected by lipid content in fish muscle. If the lipid content in fish meat can be adjusted to a satisfactory level, we may be able to provide fish meat with safer texture for the elderly people. This study aimed to establish a method to control lipid contents of fish meat by manipulating the content of dietary amino acids. Short term feeding trial was performed with rainbow trout Oncorhynchus mykiss. Fishes fed lysine-deficient diet had approximately two-fold more lipid contents in muscle, compared to the control group. This result could contribute to development of new method for controlling fish meat texture.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #21 11:40-12:15 Progranulin is required for estrogen receptor α expression in astrocytes Mio Doke, Takashi Matsuwaki, Keitaro Yamanouchi and Masugi Nishihara Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

We have shown that progranulin (PGRN), a multifunctional growth factor, mediates some of

estrogen actions in the brain such as sexual differentiation and enhancement of adult neurogenesis. Estrogen also has potent neuroprotective actions through suppression of neuroinflammation and neurodegeneration. Since PGRN expression is facilitated by estrogen, PGRN may play important roles in estrogen actions to overcome cognitive impairment with senescence. To evaluate the underlying mechanism of the role of PGRN as a mediator of estrogen actions, the localization of estrogen receptor α (ERα) in the brain of wild-type (WT) and PGRN-deficient (KO) mice was investigated. In both genotypes, ERα was localized in neurons but not in microglia. Interestingly, ERα expression in astrocytes was discernible only in WT mice but not in KO mice irrespective of sex, sexual maturity or presence of estrogen. These results suggest that PGRN plays a crucial role in the expression of ERα in astrocytes.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #22 12:15-12:50 The analysis of the hippocampal synaptic function of the senescence-accelerated mouse prone 8. Sakiko Taniguchi, Koichi Ito Department of Food and Physiological Models, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Senescence-accelerated mouse (SAM) is an experimental animal model which shows a short lifespan and rapid advancement of senescence. Especially, SAM prone 8 (SAMP8) shows age-related impairment of learning and memory, and thus, it is a good model for studying age-related cognitive dysfunction. However, the synaptic features related to cognitive function of SAMP8 have been poorly understood. We evaluated the synaptic strength by using hippocampal slices obtained from SAMP8 with extracellular recordings to elucidate the synaptic features of SAMP8. Both field EPSP (the representative of synaptic transmission) and long-term potentiation; LTP (the representative of synaptic plasticity) declined with age and the LTP of SAMP8 attenuated earlier than that of SAM resistant 1 (SAMR1), the control strain. Our study will be helpful for future studies on aging because it is the first report evaluating the synaptic function quantitatively at SAMP8 hippocampus and corroborates the past behavioral studies of SAMP8.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #23 11:40-12:15 Feedback-modification of MKK4 leads to cell death Moriizumi Hisashi, Takanori Nakamura and Mutsuhiro Takekawa Division of Cell Signaling and Molecular Medicine, IMS, The University of Tokyo

Cancer is the top cause of death in Japan, and its death rate has increased every year. One of the

reasons is that aging of Japanese society is proceeding. In general, as people become older, gene mutations are accumulated and lead to cancer. Many mutations are found in constituent genes of SAPK (p38/JNK) pathways, which is the signaling systems that dictate cell fate decisions in response to environmental stress. Among all, MKK4 is the only gene that can activate both p38 and JNK, Importantly, mutational inactivation of MKK4 has been frequently found in many cancers, suggesting that MKK4 functions as a tumor suppressor. The precise molecular mechanism by which MKK4 inhibits cancer development, however, remains unclear. Here, we have found that JNK directly modifies MKK4 by a feedback-regulatory manner. Next we investigated the physiological significance of the feedback-regulation. As a result, it enhanced cell death in response to various stresses such as anticancer drugs. We are currently investigating the molecular mechanism as to how this modification promotes apoptosis.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #24 12:15-12:50 Vaccine Strategy for The Elderly Sayaka Hirukawa Department of Computational Biology and Medical Science, Graduate School of Frontier Science, The University of Tokyo

Considering to realization of age-friendly society, we cannot ignore the infections disease that seriously injure the elderly person’s health. Respiratory tract infection including pneumonia is major cause of death of the elderly over 80 years of age. Furthermore, there is a high possibility that one become bedridden after recovering from that kind of infectious disease. Pathogens that cause pneumonia are influenza virus, MRSA, and Pseudomonas aeruginosa and so on. We can prevent influenza virus infection by vaccine. On the other hand, there is not vaccines for MRSA and Pseudomonas aeruginosa. Therefore we need to develop vaccines to prevent pneumonia. Our groups has reported certain form of Helicobacter pylori is taken up by peyer’s patches that is lymph node and can induce immune response efficiently. This report suggest this form of Helicobacter pylori can be used as vaccine antigen. I will present the vaccine strategy using Helicobacter pylori.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #25 11:40-12:15 Characterization of the antigenic properties of influenza A(H1N1)pdm09 virus Atsuhiro Yasuhara1, Seiya Yamayoshi1, Mutsumi Ito1, Ryuta Uraki1, Sumiho Nakatsu1, Kohei Oishi1, Priyanka Soni1, Toru Takenaga1, Chiharu Kawakami2, Emi Takashita3, Tadahiro Sasaki4, Kazuyoshi Ikuta4, Shinya Yamada1 and Yoshihiro Kawaoka1,5,6 1 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo. 2 Yokohama City Institute of Public Health, Yokohama, Kanagawa. 3 Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo. 4 Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka. 5 Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, USA. 6 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo.

Influenza has a great impact on the morbidity and mortality rates of elderly people. The influenza A(H1N1)pdm09 virus first appeared and caused over 18,300 deaths in 2009. Vaccination is an important strategy to protect against influenza. Vaccines mainly induce neutralizing antibodies to hemagglutinin (HA), a surface glycoprotein of influenza virus. However, mutations in HA occur easily, enabling the virus to escape from antibody neutralization. This is known as “antigenic drift”. To date, antigenic drift of the A(H1N1)pdm09 virus has not been reported. Nonetheless, to be prepared for the future antigenic drift of the A(H1N1)pdm09 virus, it is important to understand its precise antigenic site. Therefore, we analyzed the antigenic properties of A(H1N1)pdm09 HA. We generated 13 neutralizing monoclonal antibodies specific to A(H1N1)pdm09 virus and analyzed the epitopes of these antibodies. As a result, we identified 10 amino acids as antigenic sites of A(H1N1)pdm09 HA.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #26 12:15-12:50 Development of Smart Hydrogel Materials Applicable for 3D Tissue Construction via Bioprinting Yoshiyuki Nakagawa Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo In the era of hyper-aged society, there is a growing demand for medical techniques that can minimize decrease in quality of life (QOL) as a result of various diseases arising from aging. Regenerative medicine is a fascinating approach to meet this demand. Regenerative medicine is an emerging research field, where people try to regenerate tissues for transplantation aiming at recovery of various physical functions. Recent progress in regenerative medicine has paved the way for regenerating some thin tissues such as retinal pigment epithelium or skin. On the other hand, regeneration of thick, three-dimentional (3D) tissues is a big challenge in this field. Recently, 3D bioprinting technologies have attracted great interests as a tool for fabricating such thick tissues. However, limited choices of materials applicable for bioprinting (bioinks) are a bottle-neck in the field of bioprinting. In this study, novel ionically cross-linkable gels that can be potentially used for bioinks for bioprinting are demonstrated.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #27 11:40-12:15 Free Viewpoint Image Generation for Robot Teleoperation in Indoor Environments Using Body Mounted Cameras and a Laser Rangefinder Ren Komatsu Graduate School of Engineering, The University of Tokyo

Robot teleoperation is useful for elderly people with severe impairments or frailties to bring necessary things to them. In the conventional method, operators need to teleoperate robots watching images first person perspective images, and it is difficult to understand relation between robots and obstacle. Therefore, a lot of research has been done to present images for safety robot teleoperation. Operators greatly benefit from free viewpoint images of the environment around the robots in indoor environments. Using free viewpoint images, they can easily find guide maps which is effective for self-localization and overall perspective of environments without moving robots. In this paper, a novel free view point image generation method is proposed. We use multiple cameras and a laser rangefinder mounted on a robot, and generate images with the assumption that walls are perpendicular to the floor surface. Experimental results show that our system can generate free viewpoint images in real time.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #28 12:15-12:50 Navigation system for the minimally invasive surgery by compensating body motion Akihiro Kubota Graduate School of Engineering, The University of Tokyo

The surgery for the elderly has physical invasion and mental invasion. Size and postoperative recovery time of the holes is proportional. Deliria occurs because of surgery. Though it is effective that a small camera called endoscope reduces such invasiveness compared with conventional abdominal surgery, this surgery has a problem that the field of view is narrow and operation of surgical tool is difficult. Therefore engineering support is needed. In this study, field of view expansion is developed to support the operation of the physician. Previously, 3d image mapping framework such as SLAM and SFM assumes that object is rigid. Therefore, we use inertial measurement unit sensor attached to stereo endoscope and 3D reconstruction of object in front of camera is done by triangulation. Currently, position and pose estimation of endoscope could be done. In the future, we will cope with 3D and moving object.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #29 11:40-12:15 Developing frailty evaluation system to prevent falls in daily lives from human motion: Preliminary examinations Emiko Uchiyama, Takano Wataru, Yoshihiko Nakamura Department of Mechano-Informatics, Graduate school of Information Science and Technology In this research, we aim at constructing frailty evaluation system that supports predictions of risks of falls in many situations in daily lives from only a short motion motions in clinical situations. In this poster session, we show our experimental system and results of preliminary analysis on motion capture. In the preliminary experiment, we put 35 markers onto a subject and captured motions when a subject was walking, climbing up/down stairs, doing 2-step test, and standing on one leg. At the same time, we put 8 EMGs onto a subject and measured muscle activities. We analyzed the motions by biomechanical approaches. Through inverse kinematics and inverse dynamics, we acquired joint angles, joint torques, and subsequently muscle activities. Using machine learning to combine these data with other types of data, such as motion data taken at other surroundings, brain activity data, or questionnaires, we can construct a system that associate human motions with other risk factor of fallings.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #30 12:15-12:50 Mechanism of falls in the elderly related with Architectural factors: A qualitative study Shujirou Imaeda Nishide Laboratory, Department of Architecture, Graduate School of Engineering, The University of Tokyo

Introduction: To explore the mechanism of falls and to classify the type of falls are purpose of this study in order to identify the architectural and environmental factors which cause the fall and fracture. Method: A home-visit interview is performed in Bunkyo Ward and Aoba Ward to reveal how people fall in residential area. Result: In both areas 18 people who have experience of fall cooperated with this interview and 8 people have multiple falls. Total number of falls are 34 and how to fall could be classified in 6 types. 15 cases are related with steps including stair, but there are 3 types of fall. 8 cases of them caused by their belief that there was no steps in the last step of stairs, their feet were not rise as they thought or they didn't notice step itself. Conclusion: The actual situation of falls of the elderly and the architectural factors related with falls were revealed. The results of this study would be helpful to suggest how prevent the falls inside home and how renovate the house.

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Poster Presentations by GLAFS-UTokyo Students Ito Hall Event Space, B2F #31 11:40-12:15 Geographical Factors in Siting Providers and Users of Home-visit and Day-care Services : Focusing on Service Area of the Facility Type Kim Kyoungmin Department of Architecture, Graduate School of Engineering, The University of Tokyo, Tokyo

This study aims to identify optimal geographic distributions of providers (or “living spheres”) for elderly in a municipality. To accomplish this, we analyze time-distance about service attribute of day-care and home-visit service. In addition, we classify the regional difference of urban and rural area.

A network analysis based on Geographic Information System (GIS) date was conducted using Long-Term Care Insurance (LTCI) records of clients and their chosen providers in Kashiwa City, Chiba Prefecture.

It was found that day-care service is subject to the average of time-distance (14.3 min.), while home-visit service is subject to the number of users (94 persons). And, in the urban area, the average time-distance of home-visit service is shorter than the average time-distance of all areas, but in the rural area, the average time-distance of day-care service is longer.

Time-distance and other geographical considerations should be taken into account when new providers are established, and especially in planning “Relocation of architectural function ” as good environments for frail older people.

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