Univerzita Karlova v Praze, 1. lékařská fakulta, Laboratoř biokybernetiky a počítačové podpory výuky

HumMod – Golem Edition Human Physiology Model

J.Kofránek, M.Mateják, P.Privitzer, T.KulhánekJ.Šilar, F.Ježek, S.Matoušek

History

• 1972 – A.Guyton & col.: Overall circulation• 1978 – N.Ikeda & col.: Body fluids• from 1997 – J.Kofranek & col.:Physiolibrary• 2005 – S.Andersen & col.: OSA• 2008 – T.Coleman & col.: QHP 2008 beta 2• 2010 – T.Coleman & col. : HumMod

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

DS 2009• T.Coleman

DS 2009

VascularCompartments QHPViewSpl

anch

nicV

eins

Equations

2833 files in 772 folders2833 files in 772 folders

HumMod GolemEdition

CardioVascular

Metabolism

Heat

Water

Proteins

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

Gases

Electrolytes

Nerves

Hormones

Status

Oxygen

Carbondioxyd

Titratable Hydrogen Ion

Respiratory Center

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

Gases

Concentration Conpartement

Tissues Oxygen

Blood O2 Diffusion

Alveolar Ventilation

Breathing

Blood O2 Measurement

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

Oxygen

Concentration Conpartement

Tissues: H+ in blood, IST and ICF

Renal Acidification: H+ and NH4+

Blood pH Measurement

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

Titratable Hydrogen Ion

Model Setup/Inputs• Initial state values (~150)

– Masses, Volumes, ..– Steady State

• Parameters and Constants (~4000)– Characterizations of Elementary things– Identification (Also Indirect Meassurement)

• Simple Environment Model– Meat, Air, Exercise, Intravenous Nutritions,

Transfusion, Dialysis, Hemorrhage, ...

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

HumMod.Library

• Domains:– Hydraulic (mmHg, ml/min, ..)– Concentration (mol/ml, mol/min, ..)– Osmotic (mol/ml, ml/min, ..)– Termoenergetic (K, kCal/min, ..)

• Simple blocks:– Resistance, Accumulation, Pump, Outflow, Absorbtion, Chemical

reaction ..

Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

HumMod Golem Edition

heart

pulmonaryCir?

systemicCircula?

systemicCirculation

redCells

bloodPropert?

busConnector

Carotid Artery ?

(initial 10?

Sy?

8?m?_?ml

periph?

peripheral

volumeC?

85?veins

00

1?_?ml

coll?

gra?

40

legsArtysml/?

0

hyd?

(initial 5?(initial ?

100legsVeins

ml/?

hyd?0

k=9?

G

leftC?

leftCoro?right?

rightCor?

splanchnicCirculation

Low erTorsoVeinHeight

Exercise_MusclePump_Effect

SystemicArtys_Pressure

SystemicVeins_Pressure

Gravity_Gz

LeftHeart_BloodFlow

q_inq_out

busConnector

(initial 10? GITract

GITract

06?m?_?mlS?

liver

SplanchnicVeins_Pressure

PortalVein_V0

q_inq_out

busConnector

A2Effect

ADHEf?

11.2min.?____ml

Anesth?

Viscosity

Vascul?

AplhaR?

GITract

PO2On?

AlphaBlocade_Effect

AlphaPool_Effect

GangliaGeneral_NA

ADHPool_Log10Conc

A2Pool_Log10Conc

GITract_PO2

GITract_Function_Failed

Anesthesia_VascularConductance

Viscosity_ConductanceEffect

q_in q_out

organBloodFl?

BloodFlow

TotalAgonism

HU?

NE?

TotalAgonism

+

NE?

HU?

sw itch1

booleanConst?

Sw itch

Setting

Symps?

curveActivity

Sym

psEffect

GangliaGeneral_NA

AlphaPool_Effect

AlphaBlockade_Effect

yBase

y

Univerzita Karlova v Praze, 1. lékařská fakulta, Laboratoř biokybernetiky a počítačové podpory výuky

Thank you for attention

Marek Mateják marek.matejak@lf1.cuni.cz Jiří Kofránek kofranek@cesnet.czPavol Privitzer

HumMod Golem Edition

...

tissuesMetabolismliverMetabolism

Glucose

KetoAcids

CellProte? GILumen

Urea

Lipidsheat

lactate

aminoAcids

busConnector

GlycogenGLU_TO_GLY

LM_Glycogen?

LM_Glycogen?

LM_FA_Gluc? LM_Gluconeo?AA_TO_GLUGLU_TO_FA

Insulin?

Insulin?

Insulin?

75min

____mg

70min

____mg

42min

____mg

MassE?Glucos?LiverF?

Insulin?75min

____mg

MassE?Glucos?

LiverF?

Glucag?

Epinep?

.?

0? 0.6Glucos?LiverF?

Glucag?Glucos?Amino?LiverF?

LM_KetoacidsFA_TO_KA

1?LiverF?

FattyA?Glucag?

2.2min

____mg

m?

m?

LM_FA_Amin?AA_TO_FA

Insulin?

34min

____mg

0.? Amino?LiverF?

0.3

0.3

GLY_TO_GLU

1?

gl?

LiverFunctionEffectPortalVein_Glucagon

PortalVein_Glucose

PortalVein_Glucose

PortalVein_Glucose

EpiPool_Epi

liver_GlucoseToCellStorageFlow

s?s?

s? s?

Glucose

LM_Fatty?

Ketoacids

busConnector

s?

AminoAc?

s?

Urea

LM_Keto?

curve

curve

product

yBase

y

u

HumMod Golem Edition

vasopressin

aldosteroneangiotens?

atriopeptin

erythropo?

glucagoninsulin

renin

thyrotropin thyroxine

catechols

leptin

busConnector

InsulinPool

secretionsynth?

clear?

Portal?InsulinS?

k=?

gain

KAEffect

MassE?

1

Glucos?

Functio?

BasicF? 0.0?

uU/l k=1?

mU?

u?

I

k=(1/20)/Libr?

InsulinSynthe?

-

feedback

Ik=(1/?

LM_I?

-

feedback1

PortalVein_PlasmaFlow

ECFV_Vol

PortalVein_Insulin

Insulins?

busConnector

Insulin

LM_Insulin_InsulinDela?

curve

curveproduct

yBase

y

u