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*HumicAcid.info Editor's Note:
The term (Humic Acid) or (Humic Acids) or (Humic Substances) has
been substituted inthe following statements where the original
wording was in scientific terms that detailed
chemical compositions of Humic Acid.
Extracts From:
"Medical Aspects and Applicationsof Humic Substances"
Regarding the Anti-Inflammatory Activity ofHumic Substances
Prof. Dr. Renate Klocking & Dr. rer. nat. Bjorn
HelbigInstitute for Antiviral Chemotherapy,
Friedrich Schiller University,Jena, Germany
ANTI-INFLAMMATORY EFFECTSVarious healing effects of peat therapy
were attributed to the anti-inflammatory activity
of (Humic Substances). Taugner (1963) showed in the rat paw
edema model thatsodium humate significantly inhibits the
development of various edemas compared withuntreated controls.
As found by Klocking et al. (1968) in the same model, ammonium
humate isolated frompeat water exceeds the anti-inflammatory effect
of sodium humate and is twice as
effective as acetylsalicylic acid (aspirin) and amino-phenazone,
respectively. Amosovaet al. (1990), in evaluating the biologic
activity of HA from Tambukan therapeutic mud in
animals, found (Humic Acid) (10 mg/kg) to suppress both phases
of the inflammatoryprocess: the exudation (by 44 %) and the
proliferation process (by 50-55%).
The anti-inflammatory effect of (Humic Substances) has been
supported by a plausiblebiochemical explanation. As demonstrated by
Schewe et al. (1991), naturally occurring
(Humic Acid), and even more synthetic (Humic Acid)-like
polymers, inhibit thelipoxygenase pathway of the arachidonic acid
(AA) cascade. AA is an integral part of
the cell membrane, and the substrate for the synthesis of
eicosanoid-basedinflammation mediators such as leukotrienes,
thromboxane and prostacyclin.
Recently, (Humic Acid) (sodium humate) as well as various
synthetic HA-like polymerswere also found to suppress the
heat-induced (42 8C, 6 h) AA release of human pro-monocytic
U937cells (Dunkelberg et al., 1997; Klocking et al., 1997). The
inhibition of
AA release was most pronounced in cells treated with nontoxic
concentrations (20
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mg/mL) of 3,4-DHPOP (96%) and 3,4-DHTOP (92%), respectively
(Table 3). CHOP,sodium humate, KOP and BOP protected cells from
membrane damage at 65 90%.These findings may be indicative for
membrane-protective activities of (Humic Acid)
type substances.
Unlike 5-lipoxygenase, phospholipase A (porcine pancreas), the
rate-limiting key
enzyme of the AA cascade, is strongly activated at low (Humic
Acid) concentrations (0.1 1 mg/mL) and normalized or slightly
inhibited at high (Humic Acid) concentrations
(Klocking et al., 1999). The shape of the dose-response curve
suggests (HumicSubstances) to have a regulatory function on PLA
activity.
In referring to the function of (Humic Substances) as electron
donor-acceptor system,Jurcsik (1994) discussed the behavior of
(Humic Substances) as the consequence of a`buffering effect'; this
means that (Humic Acids) are able to produce as well as to
bindactivated oxygen species. This regulatory system is assumed to
be important for the
favorable influence of (Humic Substances) on wound healing and
killing of cancer cells(Jurcsik, 1994).
DISCLAIMER: This website presents a collection of statements
from around the worldabout the benefits of Humic Acid. This
information is provided for informational purposesonly. These
statements were variously made over several decades of time. There
are many
sources of Humic Acid around the globe, and they differ
significantly in their physical andchemical properties. This
website does not intend to provide medical advice, nor does
itintend to suggest that all Humic Acid preparations will be of
equal benefit. Nothing herein isintended to be an endorsement of or
a solicitation to purchase any particular Humic Acid
preparation. The FDA has not evaluated any statement made on
this website. Theinformation herein is not intended to diagnose any
disease, nor is it intended to prescribeany preparation that claims
to diagnose, treat, cure or prevent any disease.
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