Cellular Basis of Learning and MemoryBIPN 148

Spring 2007April 2-June 8, 2007

This course will examine the cellular and molecular mechanisms that underlielearning and memory. Top ics covered will include the role of the hippocampus inlearning and memory, neurotransmitter systems and receptors involved inlearning and memory, and biochemical mechanisms of synaptic plasticity.Emphasis will be placed on discussing experiments from the primary literature. Asolid background in cell and molecular biology is expected.

Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended.

Times: MWF at 3:00Location: CSB2Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP07/

Recommended Text Ghosh and Scanziani 2007 Lecture NotesLecture notes are available for purchase through University Readers athttp://www.universityreaders.com/students

Grading: Weekly Quizzes: 40%Group paper: 20%Group presentation: 10%Final Exam: 30%Grading is on a curve.

Discussion Sessions/TA office hours (optional)Monday, 10-11 (Lara Pickle and Lauren Hollingsworth)Thursday, 4-5 (Dan Keller, 111 5 Pacific Hall)

CONTACT INFORMATION

PROFESSORSAnirvan Ghosh, Pacific Hall 1123, aghosh@ucsd.edu, 822 4142.Massimo Scanziani, CMG 2nd Floor, massimo@ucsd.edu, 822 3839

TEACHING ASSISTANTSDan Keller, dkeller@salk.eduLara Pickle, larapickle@gmail.comLauren Hollingsworth, lholling@ucsd.edu

Office Hours for Professors by appointment

HUMAN MEMORY

DECLARATIVE(EXPLICIT)

NONDECLARATIVE(IMPLICIT)

FACTS EVENTS

PROCEDURAL (SKILLS AND

HABITS)

PRIMING SIMPLE CLASSICAL

CONDITIONING

NONASSOCIATIVELEARNING

EMOTIONAL RESPONSES

SKELETAL MUSCULATURE

MEDIAL TEMPORAL

LOBE

STRIATUM NEOCORTEX AMYGDALA CEREBELLUM REFLEXPATHWAYS

Subdivisions of Human Memory

Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.

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Ivan Pavlov

Classical Conditioning(an example of implicit memory)

Implicit Memory: Pavlovian Associative Conditioning

Conditioned Stimulus

UnconditionedStimulus

Conditioned Stimulus

UnconditionedResponse

ConditionedResponse

TRAINING

CONTEXTUAL TEST CUED TEST

•Animal is placed in novel context•Hears a tone•Receives foot shock

•Animal is returned to same context•Test for freezing behavior

•Animal is placed in modified context•Hears a tone•Test for freezing behavior

Implicit Memory: Fear Conditioning

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LiCl NaClgr

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Implicit memory: Conditioned Taste Aversion

DAY 1

DAY 2

1st Exposure to Food Item

2nd Exposure to Food Item

Injection of LiCl or NaCl

Grams Ingested on 2nd Exposure(LiCl treated group compared to NaCl treated

control)

A B

Implicit Memory: Neophobia

DAY 1

DAY 2

1st Exposure to Food Item

A

Grams Ingested(1st exposure compared to second exposure)

B

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2nd Exposure to Food Item

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Hermann Ebbinghaus(Distinction between short-term

and long term memory)

Ebbinghaus Test

ZOGMIFXELRICDAJNEQSORYANQIJGEB

Memorize this set of words

Wait for 1 minute

(keep the words in mind!)

Write down the words in sequence

Did anyone get all 10 right?

Sensory Information

Working Memory/Short term Memory(Minutes)

Long Term Memory(Hours/Days/Years)

By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory

Working Memory Requires Frontal Lobe Function

Declarative Memory Required the Hippocampus