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 http://onlinelibrary.wiley.com/doi/10.1111/php.12229/abstract? deniedAccessCustomisedMessage=user!sAuthenticated="alse Biochemical Composition and Antioxidant Properties of Lavandula angustifolia Miller Essential Oil are Shielded by Propolis Against UV Radiations 1. Gismondi Angelo, 2. Canuti Lorena, 3. Grispo Marta and 4. Canini Antonella *  Article first published online 2! "A # 2$14 %&' 1$.1111(php.1222)  Abstract + radiations are principal causes of sin cancer and aging. -untan creams ere de/eloped to protect epidermis and derma la0ers against photodegradation and photooidation. he addition of antioidant plant etracts i.e. essential oil to sunscreens is habituall0 performed, to increase their + protecti/e effects and to contrast pro5 radical and c0totoic compounds present in these solutions. According to these obser/ations, in the present or, the alteration of chemical composition and bioacti/e properties of Lavandula angustifolia Miller essential oil, eposed to + light, as in/estigated. + induced a significant deterioration of la/ender oil biochemical profile. Moreo/er, the antioidant acti/it0 of this solution, in in vitro tests and directl0 on 617581$ melanoma cells, greatl0 decreased after + treatment. &ur results also shoed that essential oil as shielded from + stress b0 propolis addition. 9/en after + treatment, bee glue highl0 protected la/ender oil secondar0 metabolites from degradation and also preser/ed their antiradical properties, both inin vitroantioidant assa0s and in cell oidati/e damage e/aluations. his research proposed propolis as highl0 efficient + protecti/e and antiradical additi/e for sunscreens, cosmetics and alimentar0 or pharmaceutical products containing pl ant etracts.

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http://onlinelibrary.wiley.com/doi/10.1111/php.12229/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=falseBiochemical Composition and Antioxidant Properties ofLavandula angustifoliaMiller Essential Oil are Shielded by Propolis Against UV Radiations1. Gismondi Angelo,2. Canuti Lorena,3. Grispo Marta and

4. Canini Antonella*Article first published online: 28 JAN 2014

DOI:10.1111/php.12229

Abstract

UV radiations are principal causes of skin cancer and aging. Suntan creams were developed to protect epidermis and derma layers against photodegradation and photooxidation. The addition of antioxidant plant extracts (i.e. essential oil) to sunscreens is habitually performed, to increase their UV protective effects and to contrast pro-radical and cytotoxic compounds present in these solutions. According to these observations, in the present work, the alteration of chemical composition and bioactive properties ofLavandula angustifoliaMiller essential oil, exposed to UV light, was investigated. UV induced a significant deterioration of lavender oil biochemical profile. Moreover, the antioxidant activity of this solution, inin vitrotests and directly on B16-F10 melanoma cells, greatly decreased after UV treatment. Our results also showed that essential oil was shielded from UV stress by propolis addition. Even after UV treatment, bee glue highly protected lavender oil secondary metabolites from degradation and also preserved their antiradical properties, both inin vitroantioxidant assays and in cell oxidative damage evaluations. This research proposed propolis as highly efficient UV protective and antiradical additive for sunscreens, cosmetics and alimentary or pharmaceutical products containing plant extracts.