12
A warm welcome to Bronwyn Davidson, who has replaced June Younes as the new Review Group Secretary. Bronwyn is from East London, South Africa and is now living in Aberdeen. The group would like to thank June Younes for all her assistance and wish her well in her new job. Edition 8 1 June 2005 COCHRANE Edition 8 INCONTINENCE REVIEW GROUP June 2005 H E A L T H S E R V I C E S R E S E A R C H U N I T What do we do? The Cochrane Collaboration is an international organisation that aims to help people make well- informed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions. The Cochrane Incontinence Group is a Collaborative Review Group (CRG) of the Cochrane Collaboration. We undertake systematic reviews of randomised controlled trials on different interventions designed to prevent or treat incontinence and related conditions, or aid rehabilitation. The group is concentrating on interventions where incontinence is the primary problem. The problems covered include urinary and faecal incontinence, enuresis, day-time wetting in children, encopresis, postprostatectomy incontinence, use of urinary catheters including catheter-related urinary tract infections (but not other infections), enterocutaneous and enterovesical fistulae, neurogenic incontinence and retention, interstitial cystitis, postoperative urinary retention and rectal or vaginal prolapse. In this issue Staff news ............................................................1 Profile of our Co-ordinating Editor Adrian Grant ........................................................2 Abstract of a newly published review: Surgical management of pelvic organ prolapse in women ................................................................3 In The Cochrane Library ..................................4 Collaborators required ......................................6 What the new Information Management System of the Cochrane Collaboration means to review authors ...................................7 What does the Cochrane Collaboration logo illustrate .......................................................8 Forthcoming meetings 2005 ............................9 The editorial team and Cochrane centres Worldwide ...........................................................10 Contact details form.........................................11 Visit the Cochrane Collaboration online at www.cochrane.org Staff News THE COCHRANE COLLABORATION

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Page 1: HSRU Cochrane Newsletter 2005incontinence.cochrane.org/sites/incontinence.cochrane.org/files/... · inconclusive, although about 10% of women developed new symptoms after surgery

A warm welcome to Bronwyn Davidson, who hasreplaced June Younes as the new Review GroupSecretary. Bronwyn is from East London, SouthAfrica and is now living in Aberdeen.

The group would like to thank June Younes for allher assistance and wish her well in her new job.

Edition 8 1 June 2005

C O C H R A N EEdition 8 INCONTINENCE REVIEW GROUP June 2005

HE

A

LT H • S E RV I CE

S

•R

ES

E A R C H • U

NI T

What do we do?

The Cochrane Collaboration is an internationalorganisation that aims to help people make well-informed decisions about healthcare bypreparing, maintaining and promoting theaccessibility of systematic reviews of theeffects of healthcare interventions. TheCochrane Incontinence Group is a CollaborativeReview Group (CRG) of the CochraneCollaboration.

We undertake systematic reviews ofrandomised controlled trials on differentinterventions designed to prevent or treatincontinence and related conditions, or aidrehabilitation. The group is concentrating oninterventions where incontinence is the primaryproblem. The problems covered include urinaryand faecal incontinence, enuresis, day-timewetting in children, encopresis,postprostatectomy incontinence, use of urinarycatheters including catheter-related urinarytract infections (but not other infections),enterocutaneous and enterovesical fistulae,neurogenic incontinence and retention,interstitial cystitis, postoperative urinaryretention and rectal or vaginal prolapse.

In this issue

Staff news ............................................................1

Profile of our Co-ordinating EditorAdrian Grant ........................................................2

Abstract of a newly published review: Surgical management of pelvic organprolapse in women ................................................................3

In The Cochrane Library ..................................4

Collaborators required ......................................6

What the new Information Management System of the Cochrane Collaboration means to review authors ...................................7

What does the Cochrane Collaboration logo illustrate.......................................................8

Forthcoming meetings 2005 ............................9

The editorial team and Cochrane centresWorldwide...........................................................10

Contact details form.........................................11

Visit the CochraneCollaboration online at

www.cochrane.org

Staff News

THE COCHRANECOLLABORATION

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Cochrane Incontinence Review Group

Profile of our Co-ordinating Editor Adrian Grant

Edition 8 2 June 2005

I was greatly influenced by working with Sir IainChalmers in the 12 years before he first establishedthe Cochrane Collaboration in 1992. During the1980s Iain and I were at the National PerinatalEpidemiology Unit in Oxford. (After qualifying as adoctor I had undergone basic training in obstetricsand gynaecology and then epidemiology, hence mykeenness to work in that Unit.) By the time I joinedIain he had already started to collect references torandomised controlled trials in perinatal medicine.Over time, this developed into a formal register oftrial reports and became the basis for systematicreviews and meta-analyses, such as in the landmarkbook, Effective Care in Pregnancy and Childbirthpublished in 1989. This work was the ‘pilot’ for whatlater became the Cochrane Collaboration.

During my time in Oxford, I was also involved in aseries of trials of obstetric and midwiferyinterventions during delivery and the puerperium. Iwas struck by how commonly women reportedincontinence after childbirth (consistently 20% to25%) and developed a research interest in trying toreduce this risk.

When in 1994 I moved to direct the Health ServicesResearch Unit in Aberdeen where I am now based, Idiscovered that some of my new colleagues had abroader interest in incontinence research. Whendiscussing with them what research to do next, Ifound myself needing up-to-date systematic reviews

(as we had developed in the perinatal field) butdiscovered that these were not available. So Icontacted the then recently established CochraneCentre about this. When I discovered that no onewas covering incontinence I hesitantly offered toorganise an exploratory meeting to see if a CochraneIncontinence Group would have support. Ultimatelythis led to the Group being established with itseditorial base in Aberdeen under my co-ordinatingeditorship!

Ten years on, many (but not all) of the key decisionpoints in the prevention and treatment of urinaryand faecal incontinence are now covered with over40 Cochrane reviews. This represents hard work bylarge numbers of contributors. We have found thatthe evidence base is often weak. However, higherquality new trials are consistently being conductedand reported. For this reason, in addition toensuring fuller coverage, a key role now for theGroup is ensuring that our reviews are kept up todate in the light of new evidence.

We have come a long way but there is still a greatdeal to do. I am so much looking forward tocontinuing to work with all our collaborators todeliver information that really is helpful to decision-making for the prevention and treatment ofincontinence.

AAddrriiaann GGrraanntt

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Cochrane Incontinence Review Group

Edition 8 3 June 2005

Consumer SynopsisThere was not enough evidence about the effects ofdifferent types of surgery for pelvic organ prolapse.

Pelvic organs, such as the uterus, bladder or bowel,may protrude into the vagina due to weakness in thetissues that normally support them. The symptomsthat they cause vary, depending on the type ofprolapse. The types of surgery also vary, dependingon the type of prolapse and associated symptoms.The impact of pelvic organ prolapse surgery onbowel, bladder and sexual function can beunpredictable. The review of trials demonstratedthat abdominal sacral colpopexy may be better thanthe vaginal sacrospinous colpopexy for uterine orvault prolapse. Limited evidence suggests thatvaginal surgery may be better than transanalsurgery for posterior vaginal wall prolapse. However,there was not enough evidence about most types ofcommon prolapse surgery.

AbstractBBaacckkggrroouunndd:: Pelvic organ prolapse may occur in up to50% of parous women. A variety of urinary, boweland sexual symptoms may be associated withprolapse.

OObbjjeeccttiivveess:: To determine the effects of surgery inthe management of pelvic organ prolapse.

SSeeaarrcchh ssttrraatteeggyy:: We searched the CochraneIncontinence Group trials register (8 June 2004)and reference lists of relevant articles. We alsocontacted researchers in the field.

SSeelleeccttiioonn ccrriitteerriiaa:: Randomised or quasi-randomisedcontrolled trials that included surgical operationsfor pelvic organ prolapse.

Four investigators were contacted for additionalinformation with two responding.

MMaaiinn rreessuullttss:: Fourteen randomised controlled trialswere identified evaluating 1004 women. Abdominalsacral colpopexy was better than vaginalsacrospinous colpopexy in terms of a lower rate ofrecurrent vault prolapse (Relative risk 0.23, 95% CI0.07 to 0.77) and less dyspareunia (Relative risk0.39, 95% CI 0.18 to 0.86), but the trend towards alower re-operation rate for prolapse followingabdominal sacrocolpopexy was not statisticallysignificant (Relative risk 0.46, 95% CI 0.19 to 1.11).However, the vaginal sacrospinous colpopexy wasquicker and cheaper to perform and women had anearlier return to activities of daily living. The datawere to evaluate other clinical outcomes and adverseevents.

For the anterior vaginal wall prolapse, standardanterior repair was associated with more recurrentcystoceles than when supplemented by vicryl meshoverlay (Relative risk 1.39, 95% CI 1.02 to 1.90) butdata on morbidity and other clinical outcomes weretoo few for reliable comparisons.

For posterior vaginal wall prolapse, the vaginalapproach was associated with a lower rate ofrecurrent rectocele and/or enterocele than thetransanal approach (Relative risk 0.24, 95% CI 0.09to 0.64), although there was a higher blood loss andpostoperative narcotic use. However, data on theeffect of surgery on bowel symptoms and the use ofpolyglactin mesh overlay on the risk of recurrentrectocele were insufficient for meta-analysis.

Meta-analysis on the impact of pelvic organ prolapsesurgery on continence issues was limited andinconclusive, although about 10% of womendeveloped new symptoms after surgery. However,more women with occult stress urinary incontinencedeveloped postoperative stress urinary incontinenceafter endopelvic fascia placation alone than afterendopelvic fascia plication and tension-free vaginaltape (Relative risk 5.5, 95% CI 1.36 to 22.32).

Abstract of a newly published review:Surgical management of pelvic organ prolapse in women

Maher C, Baessler K, Glazener CMA, Adams EJ, Hagen S

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Cochrane Incontinence Review Group

Edition 8 4 June 2005

AAuutthhoorrss'' ccoonncclluussiioonnss:: Abdominal sacrocolpopexy isassociated with a lower rate of recurrent vaultprolapse and dyspareunia than the vaginalsacrospinous colpopexy. These benefits must bebalanced against a longer operating time, longer timeto return to activities of daily living and increasedcost of the abdominal approach. The use of apolyglactin mesh overlay at the time of anteriorvaginal wall repair may reduce the risk of recurrentcystocele. Posterior vaginal wall repair may bebetter than transanal repair in the management ofrectoceles in terms of recurrence of prolapse.Adequately powered randomised controlled clinicaltrials are urgently needed.

Citation: Maher C, Baessler K, Glazener CMA, Adams EJ, Hagen S.Surgical management of pelvic organ prolapse in women. TheCochrane Database of Systematic Reviews 2004, Issue 4.Art.No.: CD004014. DOI: 10.1002/14651858.CD004014. pub2.

Chris Maher and Kaven Baessler at the ICI in Monaco

7. Absorbent products for containing urinaryand/or faecal incontinence in adults BrazzelliM, Shirran E, Vale L.

8. Adrenergic drugs for urinary incontinence inadults Alhasso A, Glazener CMA, Pickard R,N’Dow J.

In The Cochrane Library from the Cochrane Incontinence Review Group

Most Recent Reviews

In issue 3, 2005 we have published 6 new reviews:1. Antibiotic policies for short-term catheter

bladder drainage in adults Niël-Weise BS, vanden Broek PJ.

2. Plugs containing faecal incontinence DeutekomM, Dobben A.

3. Prevention and treatment of urinaryincontinence after stoke in adults Thomas LH,Barrett J, Cross S, French B, Leathley M,Sutton C, Watkins C.

4. Serotonin and noradrenaline reuptakeinhibitors (SNRI) for stress urinaryincontinence Mariappan P, Ballantyne Z, N’DowJMO, Alhasso AA.

5. Urinary catheter policies for short-termbladder drainage in adults Niël-Weise BS, vanden Broek PJ.

6. Which anticholinergic drug for overactivebladder symptoms in adults Hay-Smith J,Herbison P, Ellis G, Morris A.

Other Published Cochrane Reviews

9. Alarm interventions for nocturnal enuresis in childrenGlazener CMA, Evans JHC, Peto RE.

10. Anterior vaginal repair for urinary incontinence inwomen Glazener CMA, Cooper K.

11. Anticholinergic drugs versus placebo for overactivesyndrome in adults Hay-Smith J, Herbison P, Ellis G,Moore K.

12. Behavioural and cognitive interventions with orwithout other treatments for defaecation disordersin children Brazzelli M, Griffiths P.

13. Biofeedback and/or sphincter exercises for thetreatment of faecal incontinence in adults Norton C,Hosker G, Brazzelli M.

14. Bladder neck needle suspension for urinaryincontinence in women Glazener CMA, Cooper K.

15. Bladder training for urinary incontinence in adultsWallace SA, Roe B, Williams K, Palmer M.

16. Catheter policies for management of long-termvoiding problems in patients with neurogenic bladderdisorders Jamison J, Maguire S, McCann J.

17. Complementary and miscellaneous interventions fornocturnal enuresis in children Glazener CMA, EvansJHC, Cheuk DKL.

18. Conservative management of postprostectomyurinary incontinence Hunter KF, Moore KN, Cody DJ,Glazener CMA.

19. Conservative management of pelvic organ prolapse inwomen Hagen S, Stark D, Maher C, Adams E.

20. Desmopressin for nocturnal enuresis in childrenGlazener CMA, Evans JHC.

21. Drug treatment for faecal incontinence in adultsCheetham M, Brazzelli M, Norton C, Glazener CMA.

22. Drugs for nocturnal enuresis in children (other thandesmopressin and tricyclics) Glazener CMA, EvansJHC, Peto RE.

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Cochrane Incontinence Review Group

Edition 8 5 June 2005

23. Electrical stimulation for faecal incontinencein adults Hosker G, Norton C, Brazzelli M.

24. Habit retraining for the management ofurinary incontinence in adult OstaszkiewiczJ, Johnson L, Roe B.

25. Laparoscopic colposuspension for urinaryincontinence in women Moehrer B, Ellis G, CareyM, Wilson PD.

26. Management of faecal incontinence andconstipation in adults with central neurologicaldiseases Coggrave M, Wiesel PH, Norton C,Brazzelli M.

27. Mechanical devices for pelvic organ prolapse inwomen Adams E, Thomson A, Maher C, Hagen S.

28. Oestrogens for urinary incontinence in womenMoehrer B, Hextall A, Jackson S.

29. Open retropubic colposuspension for urinaryincontinence in women Lapitan MC, Cody DJ,Grant AM.

30. Pelvic floor muscle training for urinaryincontinence in women Hay-Smith EJC, Bø K,Berghmans LCM, Hendriks HJM, de Bie RA, vanWaalwijk van Doorn ESC.

31. Periurethral injection therapy for urinaryincontinence in women Pickard R, Reaper J,Wyness L, Cody DJ, McClinton S, N’dow J.

32. Physical therapies for prevention of urinaryand faecal incontinence in adults Hay-Smith J,Herbison P, Mørkved S.

33. Policies for removal of short-term urethralcatheters Griffiths R, Fernandez R.

34. Prompted voiding for the management ofurinary incontinence in adults Eustice S, Roe B,Paterson J.

35. Simple behavioural and physical interventionsfor nocturnal enuresis in children GlazenerCMA, Evans JHC.

36. Suburethral sling operations for urinaryincontinence in women Bezerra CA, Bruschini H,Cody DJ.

37. Surgery for faecal incontinence in adultsBachoo P, Brazzelli M, Grant A.

38. Surgery for complete rectal prolapse in adultsBrazzelli M, Bachoo P, Grant A.

39. Surgical management of pelvic organ prolapsein women Maher C, Baessler K, Glazener CMA,Adams EJ, Hagen S.

40. Timed voiding for the management of urinaryincontinence in adults Ostaszkiewicz J,Johnston L, Roe B.

41. Tricyclic and related drugs for nocturnalenuresis in children Glazener CMA, Evans JHC,Peto RE.

42. Types of urethral catheters for managementof short-term voiding problems in hospitalisedpatients Brosnahan J, Jull A,Tracy C.

43. Urinary catheter policies for long-termbladder drainage Niël-Wiese BS, van den BroekPJ.

44. Urinary diversion and bladder reconstruction/replacement using intestinal segments forintractable incontinence or followingcystectomy Ghulam N, McClinton S, Yong SM.

45. Urodynamic investigations for management ofurinary incontinence in children and adultsGlazener CMA, Lapitan MC.

46. Weighted vaginal cones for urinaryincontinence Herbison P, Plevnik S, Mantle J.

Other Published Cochrane Reviews (Cont’d)

In The Cochrane Library from the Cochrane Incontinence Review Group

1. Anticholinergic drugs versus non-drug activetherapies for overactive bladder syndrome inadults Patrick K, Alhasso AA, Stewart L.

2. Anticholinergic drugs versus othermedications for overactive bladder syndromein adults Dublin N, Alhasso AA, Stewart L.

3. Conservative management of nocturia in adultsReynard J, Cannon A, Abrams P.

4. Drugs for nocturia in adults Cannon A, AbramsP, Reynard J.

5. Electrical stimulation with non-implantedelectrodes for urinary incontinence in adultsBerghmans B, Bø K, Hendriks E, van Kampen M,de Bie R.

6. Lifestyle interventions for the treatment ofurinary incontinence in adults Nygaard I,Bryant C, Dowell C, Wilson PD.

7. Mechanical devices for urinary incontinence inwomen Ong EK, Glavind K, N’Dow JMO.

8. Neuromodulation with implanted electrodesfor urinary storage and voiding dysfunction inadults Herbison P, Arnold E.

9. Prevention and treatment of urinaryincontinence after stroke in adults Thomas LH,Barrett J, Cross S, French B, Leathley M, LeggL, Sutton C, Watkins C.

10. Sacral nerve stimulation for faecalincontinence in adults Mowatt G, Glazener C,Jarrett M.

Other Published Cochrane Protocols

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Cochrane Incontinence Review Group

Edition 8 6 June 2005

11. Serotonin reuptake inhibitors for stress ormixed urinary incontinence in adults MariappanP, Alhasso AA, N’Dow JMO, Pickard R.

12. Short term urinary catheter policies followingurogenital surgery in adults Phipps S, Lim YN,N’Dow J, Rane A.

13. Surgical management of bladder outletobstruction in adults with neurogenic bladderdysfunction Kalyvas K, N’Dow JMO, Swami S.

14. Surgical management of vesicovaginal and/orurethrovaginal fistulae Lapitan MC, Rienhardt G.

15. Treatment of daytime urinary incontinence inchildren Sureshkumar P, Bower W, Craig JC,Knight JF.

Interested in preparinga systematic review?Do you have an idea foran incontinence relatedsystematic review?

Would you like to preparean incontinence relatedsystematic review butare unsure of a topic?

Collaborators Required

Contact Us

June Cody, Review Group Co-ordinator of theIncontinence Group, will be happy to discuss ideasand methodology with potential reviewers.

CONTACT US! [email protected]

Additional information can be obtained from theCochrane Reviewers’ Handbook available from:

www.cochrane.org/

Training on how to write a protocol and anIntroduction to Analysis will be made availablethrough your nearest Cochrane centre

IInntteerreesstteedd iinn ppeeeerr rreevviieewwiinngg??If you would like to peer-review protocols andreviews, please indicate your areas of interest, youreducational status and if you have special knowledgeor capabilities (ie statistical analysis, scientificmethodology, etc). We will periodically request thatyou peer review a specific protocol or review.

CONTACT US! [email protected]

Other Published Cochrane Protocols (continued)

16. Types of urinary catheters for managementof long-term voiding problems in adults JahnP, Kernig A, Langer G, Preuss M, Seifert-Hühmer A.

17. Urinary catheter policies for short-termmanagement of voiding in adults Niël-WeiseBS, van den Broek PJ.

18. Washout policies for management of long-term voiding problems in catheterised adultsSinclair L, Hagen S, Niël-Weise B.

19. Which anticholinergic drug for urinaryincontinence in adults? Ellis G, Hay-Smith J,Herbison P.

IInntteerreesstteedd iinn hhaanndd sseeaarrcchhiinngg aa jjoouurrnnaall oorraabbssttrraacctt?? If you have access to journals on incontinence andwould be willing to handsearch for trials pleasecontact us.

CONTACT US! [email protected]

If you are interested in translating articles or partsof articles from any language into English, pleasecontact us.

The Cochrane Collaboration requires thatsystematic reviews include relevant studies,published and unpublished, in any language. Peopleare needed therefore to translate these studiesfrom the original language to English.

CONTACT US! [email protected]

We are seeking authors for the following titles:• Management of neuropathic bladder due to

spinal cord injury• Acupuncture for bladder dysfunction and

nocturnal enuresis in children• Artificial sphincters

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Cochrane Incontinence Review Group

Edition 8 7 June 2005

In 2005, the Cochrane Collaboration will graduallyintroduce a new Information Management System(IMS). The main purpose of the new IMS is tosupport more efficient preparation, maintenanceand publication of high quality Cochrane reviews.

The new IMS will integrate the software programscurrently used by Review Groups (Review Manager,ModMan) into one streamlined Internet-basedsystem. Using a standard Internet browser,accurate and up-to-date resources such as contactdetails, protocols, reviews, studies, review grouptopic lists, and other information will be easilyaccessible to all Cochrane entities (with theappropriate access rights).

Additional advantages of the new IMS will includethe avoidance of duplication of data; centralisedback-up and archiving of reviews and otherdocuments; a check-in/check-out system thatensures that authors, editors, and CRG staff arealways working with the latest version of a ReviewManager file; the ability to track reviews duringtheir preparation and maintenance; and theautomation of some administrative and editorialtasks.

Benefits for Authors

•• EEaassyy aacccceessss ttoo pprroottooccoollss aanndd rreevviieewwss,, wwiitthhiimmpprroovveedd vveerrssiioonn ccoonnttrrooll From within Review Manager, you will be able touse the new check-in/check-out system todownload protocols and reviews from thecentral server for editorial review and

comment. The new system will improve versioncontrol so that you will always know which is thelatest version of a review.

•• EEaassiieerr RReevviieeww MMaannaaggeerr ffiillee sshhaarriinngg wwiitthh ccoo--aauutthhoorrss aanndd yyoouurr eeddiittoorriiaall bbaasseeWhen you want to send your review or protocolto co-authors or the staff at your editorialbase, you can simply check it back into thecentral server from Review Manager, where theothers will be able to access it. It will no longerbe necessary to locate the latest version of thefile, export it from Review Manager, and attachit to an email.

•• PPrrootteeccttiioonn ooff yyoouurr RReevviieeww MMaannaaggeerr ffiilleessCentral archiving and back-up of your ReviewManager files will protect you from data loss.

•• AAbbiilliittyy ttoo mmoonniittoorr tthhee pprrooggrreessss ooff yyoouurr rreevviieewwoorr pprroottooccooll tthhrroouugghh tthhee eeddiittoorriiaall pprroocceessssBy logging onto the central server, you will beable to check which stage your draft is at inyour Group’s editorial process.

•• EEaassyy aacccceessss ttoo uupp--ttoo--ddaattee ccoonnttaacctt ddeettaaiillssBy browsing under or searching for People in thenew Information Management System, you willhave access to up-to-date contact details forstaff at your editorial base and other authorsand people within the Collaboration. Contactinformation accessed from the new InformationManagement System, whether for one person ora group of people, can then be easily exported ina format suited to your purpose. You will also beable to check and edit, if necessary, your owncontact details.

More informationIf you would like to find out more about the plansfor the IMS, an introductory paper is availablefrom:

www.cc-ims.net/download/imsg/newims.pdf.

What the new Information Management Systemof the Cochrane Collaboration means to review authors

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Cochrane Incontinence Review Group

Edition 8 8 June 2005

The Cochrane logo was designed by David Mostyn,and illustrates the objectives of the CochraneCollaboration.

The inner circle of the Cochrane logo reflects globalobjectives and international collaboration. Theadditions of the mirror image Cs initially stood forthe “Cochrane Centre”, and subsequently for“Cochrane Collaboration”.

Each horizontal line represents the results of onetrial (the shorter the line, the more certain theresult); and the diamond represents their combinedresults. The vertical line indicates the positionaround which the horizontal lines would cluster ifthe two treatments compared in the trials hadsimilar effects; if a horizontal line touches thevertical line, it means that that particular trialfound no clear difference between the treatments.The position of the diamond to the left of thevertical line usually indicates that the treatmentstudied is beneficial. Horizontal lines or a diamondto the right of the line would usually show that thetreatment did more harm than good. This dependson the outcome being used.

This particular diagram shows the results of asystematic review of randomized controlled trials(RCTs) of a short, inexpensive course of acorticosteroid given to women about to give birthtoo early. Crowley P. Prophylactic corticosteroidsfor preterm birth. The Cochrane Database ofSystematic Reviews 1996, Issue 1. Art. No:CD000065. DOI: 10.1002/14651858. CD000065.

The first of these RCTs was reported in 1972. Thediagram summarises the evidence that would have

What does the Cochrane Collaboration logo illustrate?

been revealed had the available RCTs beenreviewed systematically a decade later: it indicatesstrongly that corticosteroids reduce the risk ofbabies dying from the complications of immaturity.By 1991, seven more trials had been reported, andthe picture had become still stronger.

This treatment reduces the odds of babies of thesewomen dying from the complication of immaturity by30 to 50 per cent.

Because no systematic review of these trials hadbeen published until 1989, most obstetricians hadnot realised that this was so effective. As a result,tens of thousands of premature babies haveprobably suffered and died unnecessarily (andneeded more expensive treatment than wasnecessary). This is just one of many examples of thehuman costs resulting from failure to performsystematic, up-to-date reviews of RCTs of healthcare.

Source/copyright Cochrane CollaborationSecretariat

THE COCHRANECOLLABORATION

Meeting up with reviewers at theInternational Consultation

on Incontinence,Monaco,

June 2004

From left to right: June Cody, Sheila Wallace,Katherine Moore, Adrian Grant, Kate Williams,

Jean Hay-Smith and Mandy Fader

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Cochrane Incontinence Review Group

Edition 8 9 June 2005

COME TOTHE 13TH COCHRANE COLLOQUIUM

MELBOURNE, AUSTRALIA22- 26 OCTOBER 2005

This year’s Colloquium is to be held in Melbourne.Our Co-ordinating Editor, Adrian Grant, will bethere along with June Cody, our Review Group Co-ordinator, as well as two of our editors, Jean Hay-Smith and Peter Herbison. A special meeting isplanned for our Cochrane reviewers andcollaborators during the course of the meeting aswell as our usual Meet the Entities stand – this year‘Breakfast with the Entities’ at 8.00 am on Sunday23 October. The Colloquium is always entertainingas well as educational and is the place to be if youwant to learn more about systematic reviewmethodology, consumer and policy maker issues,widening access to and participation in Cochrane andenhancing the use of evidence in health caredecisions. If you plan to come along please let JuneCody know ([email protected]) so we can contactyou with further details about Incontinence Groupevents during the Colloquium – it would be great tosee you there.

For more details of the Colloquium the website is:

www.cochrane.org.au/colloquium

Key Dates for the Colloquium:

Abstract submission 18 April

Abstract acceptance 16 May

Stipend applications 30 May

Stipend acceptance 27 June

Early registration 15 July

Meeting room request 1 August

Hotel registration 16 September

Cancellation refunds 23 September

Colloquium 22-26 October

The International Continence Society (ICS) AnnualMeeting is being held in Montreal this year (28thAugust to 2nd September). The Incontinence Groupis running a workshop on Monday 29 August from13:00 to 16:00 entitled ‘The Cochrane IncontinenceGroup – What it is About, What it has Done andWhere it is Going’ (Workshop 12). The workshopwill be chaired by Adrian Grant and the speakers willbe: Jean Hay-Smith, Peter Herbison, CarmelaLapitan, Katherine Moore, Christine Norton, DonWilson, James N’Dow and Brian Buckley. We alsoplan to have an exhibition stand at the meeting – wewill email you nearer the time with further details.We look forward to meeting as many of you aspossible in Montreal.

Forthcoming meetings 2005

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Cochrane Incontinence Review Group

Edition 8 10 June 2005

Editorial Base Staff, Aberdeen:Adrian Grant Co-ordinating Editor, AberdeenEmail: [email protected] Cody Review Group Co-ordinatorEmail: [email protected] Wallace Trials Search Co-ordinatorEmail: [email protected] Glazener EditorEmail: [email protected] Davidson SecretaryEmail: [email protected]

THE EDITORIAL TEAM

Australasian Cochrane CentreTel: +61 3 9594 7530Fax: +61 3 9594 7554Email: [email protected]

Brazilian Cochrane CentreTel: +55 11 5575 2970Fax: +55 11 5579 0469Email: [email protected]

Canadian Cochrane CentreTel: +1 905 525 9140 Fax: +1 905 546 0401Email: [email protected]

Chinese Cochrane CentreTel: +86 288 542 2079/2078Fax: +86 288 542 2253/558 2944E-mail: [email protected]

COCHRANE CENTRES WORLDWIDE

Dutch Cochrane CentreTel: +31 20 566 5602Fax: +31 20 691 2683Email: [email protected]

German Cochrane CentreTel: +49 761 203 6715Fax: +49 761 203 6712Email: [email protected]

Iberoamerican Cochrane CentreTel: +34 93 291 9527Fax: +34 93 291 9525Email: [email protected]

Italian Cochrane CentreTel: +39 02 3901 4327Fax: +39 02 355 9048Email: [email protected]

Nordic Cochrane CentreTel: +45 3545 7112Fax: +45 3545 7007Email: [email protected]

South African Cochrane CentreTel: +27 21 938 0911Fax: +27 21 938 0200Email: [email protected]

UK Cochrane CentreTel: +44 1865 516300Fax: +44 1865 516311Email: [email protected]

US Cochrane CenterTel: +1 401-863-9950Fax: +1 401-863-9944E-mail: [email protected]

From left to right: Cathryn Glazener, Christine Norton, June Cody, Jean Hay-Smith, Adrian Grant, DonWilson, Katherine Moore, Carmela Lapitan, Sheila Wallace, Peter Herbison

Editors:Jean Hay-Smith Otago, New ZealandEmail: [email protected] Herbison Statistics and Criticism Editor,Otago, New ZealandEmail: [email protected] Lapitan Manila, PhilippinesEmail: [email protected] Moore Edmonton, CanadaEmail: [email protected] Norton, London, UKEmail: [email protected] Wilson Otago, New ZealandEmail: [email protected]

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Cochrane Incontinence Review Group

Edition 8 11 June 2005

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Cochrane Incontinence Group, Health Services Research UnitUniversity of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UKTel: +44(0)1224 551102 Fax: +44(0)1224 554580 E-mail: j.cody:abdn.ac.uk

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