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3 4 How to use ReFissa ® Tretinoin Cream, USP (Emollient) 0.05% To get the full effect of ReFissa, use it for at least 24 weeks. Each night, gently wash your face with a mild soap or cleanser and pat dry. Let your face dry for 20 to 30 minutes before applying ReFissa. Squeeze a pearl-sized amount (1/4” in diam eter) of ReFissa onto your finger. Dot ReFissa onto cheeks, forehead, and chin. Spread evenly. Avoid the eyes and the skin around the ears, lips, and nostrils. STEP STEP What to expect month by month. he signs of irritation end after a couple of months. If your skin becomes too irritated, consult with your doctor, who may suggest you try using it every other night. Then resume nightly treatment when you can. You may notice that skin is smoother and has a softer texture. wrinkles may begin to diminish. You may see an overall improvement in the texture and appearance of your skin. You may continue to see and feel your skin texture and skin tone improve. Continue to use ReFissa nightly and apply sunscreen daily (SPF 15 or higher). 0-1 1-2 3-4 6-12 1 STEP 2 STEP

How to use ReFissa Tretinoin Cream, USP (Emollient) 0.05%Try these skin care tips while using ReFissa®. Maintain your current skin care program of soap or cleanser and daily sunscreen

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Page 1: How to use ReFissa Tretinoin Cream, USP (Emollient) 0.05%Try these skin care tips while using ReFissa®. Maintain your current skin care program of soap or cleanser and daily sunscreen

3 4

How to use ReFissa® Tretinoin Cream, USP (Emollient) 0.05%

To get the full effect of ReFissa, use it for at least 24 weeks.

Each night, gently wash your face with a mild soap or cleanser and pat dry.

Let your face dry for 20 to 30 minutes before applying ReFissa.

Squeeze a pearl-sized amount (1/4” in diameter) of ReFissa ontoyour finger.

Dot ReFissa onto cheeks, forehead, and chin. Spread evenly. Avoid the eyes and the skin around the ears, lips, and nostrils.

STEPSTEP

What to expect month by month.

he signs of irritation end after a couple of months. If your skin becomes too irritated, consult with your doctor, who may suggest you try using it every other night. Then resume nightly treatment when you can.

You may notice that skin is smoother and has a softer texture.

wrinkles may begin to diminish. You may see an overall improvement in the texture and appearance of your skin.

You may continue to see and feel your skin texture and skin tone improve.

Continue to use ReFissa nightly and apply sunscreen daily (SPF 15 or higher).

0-1

1-2

3-4

6-12

1

STEP

2

STEP

Page 2: How to use ReFissa Tretinoin Cream, USP (Emollient) 0.05%Try these skin care tips while using ReFissa®. Maintain your current skin care program of soap or cleanser and daily sunscreen

Try these skin care tips while using ReFissa®.Maintain your current skin care program of soap or cleanser and daily sunscreen. Continue your usual makeup routine. Avoid the sun (including sunlamps) and always use a sunscreen (minimum SPF 15) when outdoors—even on a cloudy day. Avoid hair and face products that contain alcohol, astringents, menthol, spices, or lime. These ingredients may irritateyour skin. Avoid using electrolysis, hair depilatories, or waxes on your face. Keep hair dye or permanent-wave solutions off your face.

All of the information on this card and more is

Patient Booklet included in the Patient Starter Kit.

The Fine Wrinkles Retinoid

hyperpigmentation, and tactile roughness in patients who use a comprehensive skin care and sunlight-avoidance program (including sunscreen).

ReFissa does not eliminate wrinkles, repair sun-damaged skin, reverse photoaging, or restore more youthful or younger skin.

Do not use if the patient is taking drugs known to be photosensitizers, pregnant, attempting pregnancy, or nursing. ReFissa, early in treatment, may cause redness, itching, burning, stinging, and peeling. If the degree of irritation warrants, patients should be advised to use less medication and decrease the frequency of application.

Please see full prescribing information.

ReFissa is a registered trademark ofSuneva Medical, Inc.

© 2013 Suneva Medical, Inc. All rights reserved.

SM 1321-34 REV00