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Hosea M. Nelson Presented by Eliseo E. Quiroz BRG Meeting July 21, 2020

Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

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Page 1: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Hosea M. NelsonPresented by Eliseo E. Quiroz

BRG Meeting

July 21, 2020

Page 2: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Curriculum Vitae

• Completed B.S. in Chemistry at UC Berkeley in 2004

• Earned Ph.D. in 2012 at Caltech under Brian Stoltz

• From 2012-2015, postdoc appointment with Dean Toste at UC Berkeley

• Joined UCLA faculty in 2015

http://www.thenelsonlab.com/members1.html

Page 3: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Research Interest

• Organic catalysis and synthesis

• Chemical biology

• Structural chemistry

http://www.thenelsonlab.com/research.html

Page 4: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

C-H Insertion

Shao, B.; Bagdasarian, A.; Popov, S.; Nelson, H. M. Science, 2017, 355, 1403-1407

WCA = Weakly coordinating anion

Page 5: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

C-H Insertion

Shao, B.; Bagdasarian, A.; Popov, S.; Nelson, H. M. Science, 2018, 361, 381-387

Page 6: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

C-H Insertion

Wigman, B.; Shao, B.; Bagdasarian, A.; Popov, S.; Nelson, H. M. J. Am. Chem. Soc. 2019, 141, 9140-9144 Wigman, B.; Shao, B.; Bagdasarian, A.; Popov, S.; Nelson, H. M. Org. Lett. 2020, XXX, XXX-XXX

Page 7: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Ring-Opening Metathesis Polymerization

Nistanaki, S.; Nelson, H. M. ACS Macro Lett. 2020, 9, 731-735

Page 8: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Small MoleculeStructure Determination

• Use of the electron cryo-microscopy (cryoEM) method microcrystal electron diffraction (MicroED) to structural determination of small organic molecules on atomic resolution (<1 A).

Jones, C. G.; Martynowycz, M. W., Nelson, H. M. ACS Cent. Sci. 2018, 4, 1587-1592

Page 9: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

Small MoleculeStructure Determination

Jones, C. G.; Martynowycz, M. W., Nelson, H. M. ACS Cent. Sci. 2018, 4, 1587-1592

Page 10: Hosea M. Nelson - sites.science.oregonstate.edusites.science.oregonstate.edu/chemistry/blakemore/... · lor3 (2 mol%) Et3SiH (1.5 equiv) 30 oc, 1-3 h alkyl OTf (2 mol%) Et3SiH (1.5

THANK YOU!!