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© Arthritis Research UK 2010
HORIZON SCANNING: MUSCULOSKELETAL PAIN DISORDERS
JUNE 2010 The object of these Horizon Scanning reports is to highlight recently completed and ongoing clinical trials, research recommendations and new and emerging health technologies. After feedback from pilot Horizon Scanning exercises and following consultation with the Musculoskeletal pain disorders CSG lead, this first Horizon Scanning report only highlights ongoing clinical trials or those completed during 2008/2009. Details of all material included in this report are shown in the appendix, sorted according to anatomical region involved. Further details of each study can be obtained via the links given to the relevant webpage.
CONTENTS SEARCH METHODOLOGY 3
RESULTS 4
ABBREVIATIONS 5
APPENDIX: CLINICAL TRAILS 6
A1: Hand, Wrist, Finger & Thumb pain………………………………………………. 6
Behavioural, education & exercise including physiotherapy 6
Device 7
Drugs including biologics 8
Other including CAM therapies 12
Miscellaneous observational studies 13
A2: Elbow pain ……………………………………………………………………………….. 14
Behavioural, education & exercise including physiotherapy 14
Device 15
Drugs including biologics 16
Other including CAM therapies 17
A3: Shoulder pain ……………………………………………………………………………….. 19
Behavioural, education & exercise including physiotherapy 19
Device 22
2
Drugs including biologics 23
Others including CAM therapies 26
Miscellaneous observational studies 29
A4: Neck pain ……………………………………………………………………………….. 29
Behavioural, education & exercise including physiotherapy 29
Device 32
Drugs including biologics 32
Other including CAM therapies 33
Miscellaneous observational studies 36
A5: Back pain…………………………………………………………………………………. 38
Behavioural, education & exercise including physiotherapy 38
Device 49
Drugs including biologics 52
Other including CAM therapies 70
Miscellaneous observational studies 83
A6: Hip pain ……………………………………………………………………………….. 87
Behavioural, education & exercise including physiotherapy 87
Drugs including biologics 87
Other including CAM therapies 87
Miscellaneous observational studies 88
A7: Knee pain ……………………………………………………………………………….. 88
Behavioural, education & exercise including physiotherapy 88
Drugs including biologics 89
Other including CAM therapies 90
Miscellaneous observational studies 91
A8: Foot, Ankle & Toe pain ………………………………………………………….. 92
Device 92
Drugs including biologics 94
Other including CAM therapies 96
Miscellaneous observational studies 97
A9: Fibromyalgia ……………………………………………………………………………….. 98
Behavioural, education & exercise including physiotherapy 98
Device 103
3
Dietary Supplement 104
Drugs including biologics 105
Other including CAM therapies 114
Miscellaneous observational studies 116
A10: Chronic pain ………………………………………………………………………………. 118
Behavioural, education & exercise including physiotherapy 118
Device 122
Drugs including biologics 123
Other including CAM therapies 131
Miscellaneous observational studies 132
A11: Pain …….………..……………………………………………………………………………. 135
Behavioural, education & exercise including physiotherapy 135
Device 137
Dietry Supplement 138
Drugs including biologics 139
Other including CAM therapies 147
Miscellaneous observational studies 149
SEARCH METHODOLOGY Databases Searched Australian New Zealand Clinical Trials Registry; ClinicalTrials.gov; German Clinical Trials Register; ISRCTN register; MRC Clinical Trials Unit; Nederlands Trials Register; UKCRN Portfolio Database. Keywords searched Hand pain; Wrist pain; Finger pain; Thumb pain; [Meta]carpal pain; Phalangeal pain; Elbow pain; Epicondylitis; Tennis/Golfer’s Elbow; Shoulder pain; Neck pain; Cervical pain; Back pain; Sciatica; Sacroiliac pain; Hip pain; Knee pain; Ankle pain; Foot pain; Toe pain; [Meta]tarsal pain; Chronic [widespread] pain; Fibromyalgia; Pain (as a [musculoskeletal] condition); Musculoskeletal pain. Keywords and phrases were used separately or in combination; truncation was used where possible/applicable. Note: in the case of the Australian New Zealand Clinical Trials Registry the joint/anatomical region was always searched for under the category of musculoskeletal. Conditions excluded from this search
1. Surgical interventions and subsequent rehabilitation programmes, except when
compared to non-surgical interventions
2. Peri- and post-operative pain
4
3. Pain resulting from trauma e.g. fracture, dislocation, rotator cuff tears and whiplash
4. Pain primarily associated with a non-musculoskeletal condition e.g. pelvic pain,
cancer-related pain, infection, pregnancy, hemiplegic/post-stroke etc. including
somatoform pain
5. Pain syndromes e.g. Patellofemoral Pain Syndrome
6. Neuropathic pain
7. Headache
8. Facial pain including Temporomandibular Joint disorders
9. Pain associated with osteoarthritis of the knee or hip: these areas attract a
substantial amount of research and are included in the Osteoarthritis and related
disorders CSG’s Horizon Scanning report, available via the Arthritis Research UK
website. Note however, pain associated with osteoarthritis of other joints and in
general is included in this report.
Date limits This report includes trials that were completed or ongoing between May 2008 and May 2010.
RESULTS
Between May 2008 and May 2010, 792 completed or ongoing clinical trails were identified for musculoskeletal pain: these are tabulated in the appendix divided into anatomically distinct sections:
A1: Hand, Wrist, Finger and Thumb pain (n = 41); A2: Elbow pain (n = 27); A3: Shoulder pain (n = 57); A4: Neck pain (n = 50); A5: Back pain (n = 310); A6: Hip pain (n = 7); A7: Knee pain (n = 17); A8: Foot, Ankle and Toe pain (n = 33); A9: Fibromyalgia (n = 126) A10: Chronic pain (n = 112); A11: Pain (n = 98);
For clarity each section is subdivided according to type of intervention: behavioural, device, dietary supplement, drug, other, within which clinical trials are ordered by completion date. Unless otherwise stated in the table trials involve participants of both genders. Each clinical trial has a weblink which can be followed for further details of the study. In the general pain section (A11), diagnosed rheumatic conditions were only included when the focus of the study was pain associated with the pathology as opposed to the treatment of the disease as a whole (this is particularly pertinent to the drug/biologic trials).
5
ABBREVIATIONS
Adt Adult (18-65 years) CAM Complementary and Alternative Medicine CBT Cognitive Behavioural Therapy/Treatment Child Child (<18 years) Comp Completed CT ID Clinical Trials Identifier Expand Expanded Access Available F-only Female only Grps Groups Hosp Hospital Invite Invite only M-only Male only MSK Musculoskeletal n Enrollement N/K Not known NR Not recruiting OA Osteoarthritis RA Rheumatoid arthritis Rec Recruiting Recruit Recruitment Sen Senior (>65 years) Susp Suspended. Term Terminated Uni. University Wtdwn Withdrawn
6
CLINICAL TRIALS Clinical trials identity number (CT ID): Prefix of NCT denotes National Clinical Trials Identifier and ISRCTN an International Standard Randomized Controlled Trial Number; UKCRN – UK Clinical Research Network; ACTRN – Australian New Zealand Clinical Trials Registry; NTR – Nederland Trial Register; DRK – German clinical Trials Register. Note: Where no end date was given the following were used: completion date for primary outcome measure – italics; last update – preceeded with a ?; start date + final timepoint of outcomes – preceeded with a >.
A1: HAND, WRIST, FINGER & THUMB PAIN
Title Phases: study design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
SARAH: Stretching and Strengthening for Rheumatoid Arthritis of the Hand: The clinical and cost effectiveness of an exercise programme over and above usual care RCT ISRCTN89936343
Standard care + optimized exercise; Standard care
RA, Hand; RA, Wrist
Active 480 Adt Sen
Nov-08 Apr-12 University of Warwick http://www.controlled-trials.com/ISRCTN89936343
Randomised and controlled study of the effect of ergonomics orientation and motor control exercises in patients with WRUED RCT (active) ISRCTN28200443
Ergonomic orientation + motor control training; ergonomics orientation
Work-related upper extremity disorders Nb: exclusion of diagnosed fibromyalia or rheumatic disease
Active 60 Aadt Aug-10 Apr-11 Federal University of Juiz de Fora, Brazil
http://www.controlled-trials.com/ISRCTN28200443
The efficacy of a multidisciplinary treatment program in patients with osteoarthritis of the hands. RCT (active) NTR1191
Multidisciplinary treatment program; Education + instruction about exercises
Hand OA Active 150 N/K Jan-08 Jan-11 Dutch Arthritis Association
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1191
7
Effectiveness of Occupational Therapy in Patients With Rheumatoid Arthritis (RCT) RCT (active), Efficacy Study NCT00400868
Psycho-educational Joint protection education
Rheumatoid Arthritis
Comp 54 Adt Sen
Jul-06 Sep-09 University of Zurich; Zürcher Rheumastifung; Gertrude und Wolfgang Schrader-Dislich Stiftung; Swiss Ligue Against Rheumatism, Zurich, Switzerland
http://ClinicalTrials.gov/show/NCT00400868
Self-management, joint protection education and exercise in hand osteoarthritis: a randomised controlled trial in the community RCT ISRCTN33870549
Joint protection principles + usual care; Hand exercises + usual care; Joint protection + hand exercises + usual care; Usual care
Hand OA Comp 252 Adt Sen
Jun-06 May-08
Keele University http://www.controlled-trials.com/ISRCTN33870549/ISRCTN33870549
Device
Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Phase II: RCT (active), Efficacy Study NCT01093209
Interferential Laser Therapy
Carpal Tunnel Syndrome; Neuropathic Pain
Rec 106 Adt Sen
Feb-10 Mar-11 Hospital Universitario Ramon y Cajal
http://ClinicalTrials.gov/show/NCT01093209
Effect of orthoses in hand osteoarthritis RCT ISRCTN40357804
Orthosis; Exercise Carpo-metacarpal joint OA
Active 60 Adt Sen
Nov-08 Dec-10 Diakonhjemmet Hospital, Norway
http://www.controlled-trials.com/ISRCTN40357804
Effect of Celliant Materials on Pain and Blood Oxygenation in Subjects With Chronic Elbow and Wrist Pain Prospective, Case Control Study NCT00688220
Celliant garment; Placebo celliant garment
Chronic Wrist Pain; Chronic Elbow Pain
Not yet Rec
80 Adt Sen
Dec-09 Dec-10 Southern California Institute for Research and Education; Hologenix, LLC
http://ClinicalTrials.gov/show/NCT00688220
A Clinical Trial of Splinting for DeQuervain's Tenosynovitis Prospective, Cohort Study NCT00438191
Full time splint wear; As needed splint wear
DeQuervain's Tenosynovitis
Rec 80 Adt Sen
Dec-05 Dec-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00438191
8
CMC Arthritis - Neoprene Vs. Thermoplast Short Opponens Splinting Prospective, Cohort Study NCT00438763
Neoprene splint; Thermoplast splint
Carpo-metacarpal Thumb Arthritis
Rec 70 Adt Sen
Dec-05 Dec-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00438763
Effect of Assistive Technology in patients with Hand OsteoArthritis: A randomised, controlled trial RCT ISRCTN61534918
Assistive technology + education; education
Hand OA Comp 70 Adt Sen
Apr-08 Dec-09 Diakonhjemmet Hospital, Norway
http://www.controlled-trials.com/ISRCTN61534918
CMC (Carpometacarpal) OA (Osteoarthritis) Thumb Splint Study Phase II: RCT (active), Efficacy Study NCT00705146
Comfort Cool thumb splint by North Coast Medical; Custom made thermoplastic & neoprene splint
Osteoarthritis, Carpo-metacarpal
Rec 48 Adt Sen
Apr-08 Dec-09 University of British Columbia; Vancouver Foundation
http://ClinicalTrials.gov/show/NCT00705146
Drugs including biologics
Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint Phase IV: RCT (placebo), Safety/Efficacy Study NCT01045694
Botulinum Toxin Type A; Triamcinolone Acetonide; Lidocaine
Basilar Joint Arthritis; Basal Thumb Joint Arthritis; Trapeziometa-carpal Arthritis; Carpometa-carpal Arthritis
Not yet Rec
45 Adt Sen
Jan-10 Nov-13 University of Missouri-Columbia
http://ClinicalTrials.gov/show/NCT01045694
Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Phase III: RCT (placebo), Efficacy Study NCT01068405
Methotrexate; Placebo
Polyarthritis Not yet Rec
64 Adt Sen
Mar-10 Mar-12 Centre Hospitalier Universitaire de Nice
http://ClinicalTrials.gov/show/NCT01068405
Comparison of oral prednisolone and oral indometacin in the treatment of acute gout-like arthritis: a multicentre double-blind randomised trial RCT ISRCTN45724113
Prednisolone; Indometacin
Gouty arthritis Active 400 Adt Sen
Jan-10 Dec-11 Health, Welfare and Food Bureau, Hong Kong
http://www.controlled-trials.com/ISRCTN45724113
9
A double blind, randomised, placebo controlled, multicentre trial of Anti-Tumour Necrotising Factor alpha (Anti-TNFα) chimeric monoclonal antibody (infliximab, Remicade®) in combination with methotrexate in patients with very early inflammatory arthritis RCT ISRCTN21272423
Symptomatic therapy + methotrexate + infliximab; Symtomatic therapy + methotrexate + placebo; Symptomatic therapy + placebo
Early arthritis (hand or foot involvement)
Active 200 Adt Sen
Sep-07 Sep-11 Medical Unviersity of Vienna, Austria
http://www.controlled-trials.com/ISRCTN21272423
Prolotherapy Versus Steroids for Thumb Carpo-metacarpal Joint Arthritis RCT (active), Safety/Efficacy Study NCT00685880
Prolotherapy (10% dextrose solution); Corticosteroid solution
Thumb Carpo-metacarpal Joint Osteoarthritis
Rec 40 Adt Sen
May-08 Jul-11 Mayo Clinic http://ClinicalTrials.gov/show/NCT00685880
The efficacy of Trigger Finger treatment: a randomised, controlled, prospective clinical multicenter trial. RCT (active) NTR1135
Tramcinolone acetonide A-10; „open‟ surgery
Trigger finger Active 490 Adt Sen
Jan-08 Jan-11 University Medical Centre Utrecht
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1135
Brain Imaging To Examine The Effect Of Naproxen In Hand Osteoarthritis Patients Randomized, Crossover Assignment, Pharmacodynamics Study NCT00830050
Naproxen; Placebo Osteoarthritis Not yet Rec
24 Adt Sen
F-
only
May-10 Dec-10 Pfizer; King's College London
http://ClinicalTrials.gov/show/NCT00830050
Efficacy Study of an Anti-Tumor Necrosis Factor (TNF) Alpha Agent in Patients With Hand Osteoarthritis Phase III: RCT (placebo), Efficacy Study NCT00597623
Adalimumab (Humira®); Placebo
Hand Osteoarthritis
Active, NR
84 Adt Sen
Jan-08 Dec-10 Assistance Publique Hôpitaux de Paris; Abbott
http://ClinicalTrials.gov/show/NCT00597623
Corticosteroid Injection for Common Upper Extremity Problems RCT (placebo), Efficacy Study NCT00438672
Dexamethasone Injection; Placebo Injection
Lateral Elbow Pain; deQuervain's Tendonitis; CMC Arthritis
Rec 213 Adt Sen
Apr-03 Oct-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00438672
10
A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb Phase III: RCT NCT00398866
Synvisc (Hylan G-F20; hyaluronan injection); Bupivicaine (local anesthesia injection); Kenalog (triamcinolone; corticosteroid injection)
Osteoarthritis Rec 213 Adt Sen
Aug-06 Aug-10 Hospital for Special Surgery, New York; Genzyme
http://ClinicalTrials.gov/show/NCT00398866
Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Phase II: Single Group Assignment, Safety/Efficacy Study NCT00991068
Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
Carpal Tunnel Syndrome
Active, NR
20 Adt Sen
Sep-09 Apr-10 ZARS Pharma Inc. http://ClinicalTrials.gov/show/NCT00991068
Study Comparing One Versus Two Cortisone Injections for Trigger Finger Parallel Assignment , Efficacy Study NCT00951236
One cortisone injection; Two cortisone Injections
Stenosing Tenosynovitis; Trigger Finger
Rec 392 Adt Sen
May-09 ? Mar-10
Rothman Institute Orthopaedics
http://ClinicalTrials.gov/show/NCT00951236
A randomized, double blind, placebo-controlled trial to evaluate the clinical efficacy and the structure modifying properties of etanercept 50/25 mg sc weekly in patients with erosive OA of the interphalangeal finger joints. RCT (placebo) NTR1192
Etanercept 50mg; Etanercept 25mg
OA; Erosive inflammatory hand
Active 90 Adt Sen
Mar-08 Mar-10 Leiden University Medical Center
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1192
Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Phase III: RCT (placebo), Safety/Efficacy Study NCT00266214
Lidocaine patch 5% Carpal Tunnel Syndrome
Term 310 Adt Sen
Nov-05 ? Feb-10
Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00266214
Efficacy Study of Condrosulf in the Treatment of Symptomatic OA of the Hand Phase IV: RCT (placebo), Safety/Efficacy Study NCT00291499
Chondroitin 4&6 sulfate (Condrosulf); Placebo
Osteoarthrosis Active, NR
160 Adt Sen
Jun-05 Jan-10 IBSA Institut Biochimique SA
http://ClinicalTrials.gov/show/NCT00291499
11
An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study Non-Randomized, Parallel Assignment, Safety/Efficacy Study NCT00198029
Synvisc (hylan G-F20)
Carpo-metacarpal Osteoarthritis
Rec 20 Adt Sen
Oct-04 Dec-09 Hospital for Special Surgery, New York; Genzyme; National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT00198029
Study of Non Inferiority Bi-Profenid® 200mg Versus Bi-Profenid® 300mg Among Patients Presenting of the Post-traumatic or Rheumatologic Acute Affections of the Locomotor Apparatus (BIPROPAIN) Phase III: RCT (dose comparison), Safety/Efficacy Study NCT00810121
Ketoprofen 100 mg; Ketoprofen
Pain Comp 409 Adt Nov-08 Jun-09 Sanofi-Aventis http://ClinicalTrials.gov/show/NCT00810121
Effect of Diacerein on Hand Osteoarthritis Phase IV: RCT (placebo), Safety/Efficacy Study NCT00685542
Diacerein; Placebo Osteoarthritis Rec 86 Adt Sen
Jun-08 Jun-09 Seoul National University Hospital; Myungmoon Pharm. Co.
http://ClinicalTrials.gov/show/NCT00685542
A Study To Assess The Ability Of Tramadol, Naproxen And Oxycodone To Affect The Pain Thresholds Of Patients With Osteoarthritis Of The Thumb Phase I: Randomized, Crossover Assignment, Efficacy Study NCT00743587
Oxycodone; Tramadol; Naproxen; Placebo
Osteoarthritis Thumbs
Comp 36 Adt Sen
Sep-08 Mar-09 Pfizer http://ClinicalTrials.gov/show/NCT00743587
Study to Evaluate the Efficacy of Adalimumab in Patients With Erosive Osteoarthritis of the Interphalangeal Finger Joints Phase II: RCT (placebo), Efficacy Study NCT00296894
Adalimumab (40 mg sc every other week); Placebo
Erosive Osteo-Arthritis
Comp 60 Adt Sen
May-06 Feb-09 University Hospital, Ghent
http://ClinicalTrials.gov/show/NCT00296894
12
A Phase 3, Double-Blind, Randomized, Placebo Controlled Study of the Safety and Efficacy of AA4500 in the Treatment of Subjects With Dupuytren‟s Contracture Followed by an Open-Label Extension Phase RCT (placebo), Efficacy Study ACTRN12607000216415
AA4500 (Clostridial collagenase); Placebo
Dupuytren‟s contracture
Comp 60 Adt Sen
Jul-07 > Jul-08
Auxilium Pharmaceuticals, Inc; Novotech (Australia) Pty Ltd.
http://www.anzctr.org.au/trial_view.aspx?ID=81966
Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis Phase II/III; RCT (placebo), Safety/Efficacy Study NCT00640939
Diclofenac sodium; Matching Placebo
DeQuervain's Tenosynovitis of the Wrist; and other conditions
1
Comp 308 Adt Sen
Dec-07 Jun-08 Cerimon Pharmaceuticals; PPD
http://ClinicalTrials.gov/show/NCT00640939
Other including CAM therapies
Mild Carpal Tunnel Syndrome Randomized, Parallel Assignment NCT00981565
Open carpal tunnel release; Night-cast
Carpal Tunnel Syndrome
Rec 88 Adt Sep-09 Jan-12 North Carelia Central Hospital
http://ClinicalTrials.gov/show/NCT00981565
Stop-rule management in patients with sub-acute chronic pain (WRUEP): a randomized controlled and replicated single case experimental ABCD design. RCT (active) NTR1517
Stop-rule management; Regular rehabilitation
Repetitive strain injury; non-specific work-related upper limb disorders (shoulder, arm elbow, neck, wrist, hand)
Active 12 Adt Nov-08 Nov-10 University Maastricht http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1517
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Phase I/II: RCT (placebo), Efficacy Study NCT00929123
Neural mobilization; Sham neural mobilization; Healthy controls
Carpal Tunnel Syndrome
Active, NR
60 Adt Sen
May-07 Oct-09 National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT00929123
1 Rotator Cuff Tendonitis; Bicipital Tendonitis; Subdeltoid Bursitis of the Shoulder; Subacromial Bursitis of the Shoulder; Medial Epicondylitis of the Elbow; Lateral Epicondylitis of the Elbow
13
Multidisciplinary versus traditional outpatient management of osteoarthritis: a randomised, controlled trial in Norway RCT ISRCTN25778426
Novel multidisciplinary intervention; Usual care
OA, hand; OA, hip; OA, knee; OA, generalised
Comp 400 Adt Sen
Aug-06 Aug-09 National Resource Center for Rehabilitation in Rheumatology, Norway
http://www.controlled-trials.com/ISRCTN25778426
Hyperthermia As A Conservative Treatment For Carpal Tunnel Syndrome. A Randomized "Sham" Controlled Trial RCT (placebo), Safety/Efficacy Study NCT00988923
Hyperthermia; No intervention
Carpal Tunnel Syndrome
Comp 34 Adt Sen
Oct-07 Sep-08 Catholic University of the Sacred Heart
http://ClinicalTrials.gov/show/NCT00988923
Carpal Tunnel Syndrome: Diagnosis and Treatment Trial RCT (active), Safety/Efficacy Study NCT00032227
Early Carpal Tunnel Release; Non-surgical interventions; MR Nerve Imaging for CTS
Carpal Tunnel Syndrome
Comp 116 Adt Sen
Aug-02 Apr-08 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00032227
Miscellaneous observational studies
The course of hand pain and hand problems in community dwelling adults aged 50 years and over in North Staffordshire; 54 month follow-up of the clinical assessment study of the hand (CAS-HA) Cohort study UKCRN ID 6912
Hand pain; hand problems
Active 506 Adt Sen
N/K Jul-10 Keele University http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6912
14
A2: ELBOW PAIN
Title Phases: trial design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis Phase IV: Randomized, Factorial Assignment, Efficacy Study NCT00826462
Physiotherapy + Triamcinolone + Lidocaine + Naproxene; Physiotherapy + Placebo + Lidocaine + Naproxene; Naproxene
Tennis Elbow; Epicondylitis, Lateral Humeral
Rec 174 Adt Sen
Mar-09 Mar-13 University of Oslo; Allmenn-medisinsk forskningsfond, Norway
http://ClinicalTrials.gov/show/NCT00826462
Conservative Treatment for Tennis Elbow RCT (active) ISRCTN65048343
Exercise class; Individual physiotherapy; Supervised home-class
Tennis elbow Comp 90 Adt Jul-06 Oct-09 Department of Health, UK
http://www.controlled-trials.com/ISRCTN65048343
The efficacy of combining physiotherapy and corticosteroid injection in the treatment of tennis elbow: a randomised control trial RCT (placebo) ACTRN12609000051246
Physiotherapy + Corticosteroid injection; Physiotherapy + saline injection; Corticosteroid injection; saline injection
Tennis elbow N/K 132 Adt Sen
Aug-08 > Aug-09
University of Queensland; Griffith University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=82438
Intra-articular Glucocorticoid Treatment of the Elbow RCT (active), Efficacy Study NCT00972530
Immobilisation in a triangular sling following intra-articular injection
Rheumatoid Arthritis
Comp 90 ChildAdt Sen
Jan-06 Dec-08 Department of Research and Development, County Council of Gavleborg and Uppsala University; Meda AB
http://ClinicalTrials.gov/show/NCT00972530
15
Tennis Elbow Trial Randomized, Parallel Assignment, Efficacy Study NCT00888225
Eccentric exercise; Concentric exercise
Lateral Epicondylitis
Comp 205 Adt Sen
Oct-03 Dec-08 Uppsala University; The Swedish Research Council; Amersham Foundation; Uppsala County Council, Sweden
http://ClinicalTrials.gov/show/NCT00888225
Device
Effect of Celliant Materials on Pain and Blood Oxygenation in Subjects With Chronic Elbow and Wrist Pain Observational: Prospective, Case Control NCT00688220
Celliant garment; Placebo celliant garment
Chronic Wrist Pain; Chronic Elbow Pain
Not yet Rec
80 Adt Sen
Dec-09 Dec-10 Southern California Institute for Research and Education; Hologenix, LLC
http://ClinicalTrials.gov/show/NCT00688220
Use of TPD Heat Lamp for Tennis Elbow Pain - a Randomized-Controlled Trial Phase II/III: RCT (placebo), Efficacy Study NCT00725023
TDP© Lamp; Dummy TDP© Lamp
Lateral Epicondylitis
Active, NR
116 Adt Aug-08 Oct-09 Queen's University http://ClinicalTrials.gov/show/NCT00725023
The efficacy of a specific tennis elbow brace („Go-Strap brace‟) compared to a standard counterforce brace in participants with tennis elbow RCT (active), Efficacy study ACTRN12609000354280
“Go-Strap brace”; Standard counterforce brace
Tennis elbow N/K 35 Adt Jun-09 > Jun-09
Griffith University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=83872
Study of LED Phototherapy for Musculoligamentous Lesions RCT (placebo), Efficacy Study NCT00382941
Red and near infrared LED phototherapy device
Tendinopathy; Sprains and Strains; Muscle Spasm; Epicondylitis; Fasciitis
Comp ChildAdt Sen
? Dec-08
Hermano Miguel Foundation
http://ClinicalTrials.gov/show/NCT00382941
16
Drugs including biologics
Treatment of Lateral Epicondylitis: Platelet Rich Plasma Versus Steroid Versus Saline Solution RCT (active), Safety/Efficacy Study NCT01109446
Platelet Rich Plasma; Isotonic Saline Solutions; Triamcinolon-acetonid
Lateral Epicondylitis
Rec 60 Adt Sen
Jan-09 Oct-11 University of Aarhus http://ClinicalTrials.gov/show/NCT01109446
Botulinum Toxin Versus Active Strength Training in the Treatment of Lateral Epicondylitis RCT (active), Efficacy Study NCT00930709
Botulinum toxin type A (Botox®, Allergan); Behavioral: Active strength training and stretching
Epicondylitis, Lateral Humeral; Tennis Elbow
Rec 120 Adult Mar-09 Aug-11 Seinajoki Central Hospital
http://ClinicalTrials.gov/show/NCT00930709
Corticosteroid Injection for Common Upper Extremity Problems RCT (placebo), Efficacy Study NCT00438672
Dexamethasone Injection; Placebo Injection
Lateral Elbow Pain; deQuervain's Tendonitis; CMC Arthritis
Rec 213 Adt Sen
Apr-03 Oct-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00438672
Effectiveness of Botulinum Toxin Injection in the Tennis Elbow Treatment Phase III: RCT (placebo), Efficacy Study NCT00437762
Botulinum Toxin A Injection; Placebo injection
Tennis Elbow Rec 60 Adt Sen
Apr-07 Dec-09 University Hospital, Bordeaux; Ipsen
http://ClinicalTrials.gov/show/NCT00437762
Study to Compare the Pharmacokinetics of a Dexamethasone Iontophoretic Patch to a Dexamethasone Injection Phase I: Randomized, Crossover Assignment, Pharmacokinetics Study NCT00895076
Dexamethasone injection; DexamethasoneIontophoretic Patch
Lateral Epicondylitis (Tennis Elbow)
Active, NR
12 Adult May-09
May-09
Travanti Pharma Inc.; Cetero Research
http://ClinicalTrials.gov/show/NCT00895076
Dexamethasone Iontophoretic Patch for the Treatment of Pain Associated With Lateral Epicondylitis Phase II: RCT (placebo), Safety/Efficacy Study NCT00794976
Dexamethasone Iontophoretic Patch (low dose); Dexamethasone Iontophoretic Patch (high dose); Dexamethasone Passive Patch; Placebo Patch
Lateral Epicondylitis; (Tennis Elbow)
Comp 200 Adt Sen
Oct-08 May-09
Travanti Pharma Inc.; ResearchPoint
http://ClinicalTrials.gov/show/NCT00794976
17
Platelet-rich-plasma Treating Tennis Elbow RCT (active), Safety/Efficacy Study NCT00757289
PRP Injection; Corticosteroid Injection
Pain; Tennis elbow
Comp 100 Adt Sen
Aug-07 Jan-09 Biomet, Inc. http://ClinicalTrials.gov/show/NCT00757289
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Phase III: RCT (placebo), Safety/Efficacy Study NCT00426985
Ketoprofen Topical Patch 20%
Tendonitis; Bursitis
Term 330 Adt Sen
Jan-07 Oct-08 Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00426985
Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00640939
Diclofenac sodium; Placebo
Upper limb conditions
2
including Medial Epicondylitis of the Elbow; Lateral Epicondylitis of the Elbow
Comp 308 Adt Sen
Dec-07 Jun-08 Cerimon Pharmaceuticals; PPD
http://ClinicalTrials.gov/show/NCT00640939
A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis Phase II/III: RCT (historical), Efficacy Study NCT00947765
Autologous blood injection; Local corticosteroid injection
Tennis Elbow; Epicondylitis, Lateral Humeral
Comp 60 Child Adt Sen
Jan-07 Jun-08 Jawaharlal Nehru Medical College
http://ClinicalTrials.gov/show/NCT00947765
Doxycycline for Lateral Epicondylalgia - RCT RCT (placebo), Efficacy Study NCT00631501
Doxycycline; Placebo
Lateral Epicondylalgia (Tennis Elbow)
Rec 34 Adt ? Feb-08
Kaunas University of Medicine; University Hospital, Linkoeping
http://ClinicalTrials.gov/show/NCT00631501
Other including CAM therapies
The Treatment and Advice for Tennis Elbow study RCT (active) ISRCTN87141084
Patient-controlled TENS + usual care; usual care
Tennis elbow Active 240 Adt Sen
May-05
Jun-11 Keele University http://www.controlled-trials.com/ISRCTN87141084
2 Rotator Cuff Tendonitis; Bicipital Tendonitis; Subdeltoid Bursitis of the Shoulder; Subacromial Bursitis of the Shoulder; DeQuervain's Tenosynovitis of the Wrist
18
Stop-rule management in patients with sub-acute chronic pain (WRUEP): a randomized controlled and replicated single case experimental ABCD design. RCT (active) NTR1517
Stop-rule management; Regular rehabilitation
Repetitive strain injury; non-specific work-related upper limb disorders (shoulder, arm elbow, neck, wrist, hand)
Active 12 Adt Nov-08 Nov-10 University Maastricht http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1517
Prolotherapy for the Treatment of Chronic Lateral Epicondylitis Phase II/III: RCT (placebo), Efficacy Study NCT00674622
Prolotherapy; Placebo
Lateral Epicondylitis; Tennis Elbow
Rec 60 Adt Sep-07 Sep-10 University of Pittsburgh; National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT00674622
The effect of acupuncture on lateral elbow pain compared to laser: a randomised controlled pilot study. RCT (placebo) ACTRN12609000928213
Acupuncture; Sham acupuncture
Lateral elbow pain
N/K 24 Adt Oct-09 > Dec-09
University of Technology, Sydney
http://www.anzctr.org.au/trial_view.aspx?ID=320738
Influence of Microcurrent Parameters on Effectiveness in Treatment of Chronic Tennis Elbow Phase II/III: Non-randomized, Parallel Assignment (historical), Efficacy Study NCT00905736
Microcurrent treatment (controlled current); Micocurrent treatment (controlled voltage)
Tennis Elbow Active, NR
24 Adt Sen
Apr-09 Dec-09 University of Hertfordshire
http://ClinicalTrials.gov/show/NCT00905736
Effectiveness of Microcurrent for Treatment of Tennis Elbow Phase II/III: RCT (historical), Efficacy Study NCT00817232
Microcurrent (Elexoma Medic)
Tennis Elbow Active, NR
24 Adt Sen
Dec-08 Dec-09 University of Hertfordshire
http://ClinicalTrials.gov/show/NCT00817232
Lateral Epicondylitis Iontophoresis Randomized Control Trial (LERCT) RCT (placebo), Efficacy Study NCT00435318
Iontophoresis Lateral Epicondylitis
Wtdwn 40 Adt Sen
Feb-07 Jan-09 Vanderbilt University http://ClinicalTrials.gov/show/NCT00435318
19
A3: SHOULDER PAIN
Title Phases: trial design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Operative Versus Non-operative Management of Subacromial Impingement Randomized, Parallel Assignment, Efficacy Study NCT00637013
Physical therapy; Surgery (Subacromial decompression)
Subacromial Impingement Syndrome
Rec 100 Adult Sen
Jun-08 Dec-15 Central Finland Hospital District; Academy of Finland; National Research and Development Centre for Welfare and Health
http://ClinicalTrials.gov/show/NCT00637013
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population Phase III: Single Group Assignment, Efficacy Study NCT01050972
Cognitive, Relaxation and Exercise Therapy
Migraine; Tension Type Headache; Cervical Pain; Shoulder pain
Rec 15000 Child Adt Sen
Jun-09 Nov-11 University of Turin, Italy; Fondazione CRT, Torino; Comune di Torino; Regione Piemonte
http://ClinicalTrials.gov/show/NCT01050972
Physiotherapy for shoulder impingement syndrome RCT (active) ISRCTN86900354
Physiotherapy + home-based exercise; Standard exercise
Shoulder impingement syndrome
Active 90 Adt Sen
Mar-10 Sep-11 Physiotherapie-zentrum T.O. Kromer, Germany
http://www.controlled-trials.com/ISRCTN86900354
Randomized Clinical Trial of Rehabilitation for Subacromial Impingement Syndrome RCT (active), Efficacy Study NCT00633451
Manual Therapy and Exercise; Exercise Only
Shoulder Impingement Syndrome
Rec 100 Adt Sen
Feb-08 Jul-11 Proaxis Therapy; Virginia Commonwealth Uni.; Arcadia Uni.; National Athletic Training Association Research & Education Foundation
http://ClinicalTrials.gov/show/NCT00633451
Subacromial Impingement - The Need of Arthroscopic Subacromial Decompression After Eccentric Physical Therapy Exercises Randomized, Parallel Assignment, Efficacy Study NCT01037673
Exercise program; Movement exercises
Subacromial Impingement Syndrome
Rec 100 Adt Sen
Jan-08 Mar-11 Linkoeping University
http://ClinicalTrials.gov/show/NCT01037673
20
Exercise and Manual Therapy for Shoulder Subacromial Impingement Syndrome Phase II: Single Group Assignment, Efficacy Study NCT00632996
Rehabilitation Shoulder Impingement Syndrome
Rec 225 Adt Sen
Jan-08 Jan-11 Virginia Commonwealth University; National Athletic Trainers' Association REF; University of North Florida; Arcadia University
http://ClinicalTrials.gov/show/NCT00632996
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck RCT (dose comparison) Efficacy Study NCT01027390
Physical training exercise
MSK Disorders Invite 800 Adt Sen
Jan-10 Dec-10 University of Southern Denmark; National Research Centre for the Working Environment, Denmark; University of Copenhagen
http://ClinicalTrials.gov/show/NCT01027390
Effect Study of an Eccentric Training Program and Stretching for Patients With Chronical Rotator Cuff Tendinopathy RCT (active), Efficacy Study NCT00782522
Eccentric training program; Traditional training program
Chronical Rotator Cuff Tendinopathy
Rec 90 Adt Apr-09 Dec-10 University Ghent; BOF
http://ClinicalTrials.gov/show/NCT00782522
The Clinical Efficacy of Belting Stabilization for Shoulder Pain Phase I: RCT (placebo), Efficacy Study NCT00826293
Stabilization belt
Rotator Cuff Impingement Syndrome
Invite 64 Adt Jan-09 Dec-10 Sunnybrook Health Sciences Centre
http://ClinicalTrials.gov/show/NCT00826293
Shoulder Training: Muscle Recruitment Patterns and the Effect of an Exercise Program Controlled trial (active), Efficacy Study NCT00774956
Exercise training program
Shoulder Impingement
Rec 60 Adt Sep-08 Dec-10 University Ghent http://ClinicalTrials.gov/show/NCT00774956
Physical activity to prevent deterioration in cleaners RCT ISRCTN96241850
Physical coordination training; Cognitive behavioural training; Health check
Shoulder pain; Neck pain
Active 400 Adt Aug-07 Dec-10 The Ministry of Culture Committee on Sports Research
http://www.controlled-trials.com/ISRCTN96241850
21
Effect of Kettlebell Training on Musculoskeletal and Cardiovascular Health Randomized, Factorial Assignment NCT01076127
Ketllebell training; Control
MSK Disorders; Neck pain; Shoulder pain; Back pain
Active, NR
40 Adt Mar-10 Aug-10 National Research Centre for the Working Environment, Denmark
http://ClinicalTrials.gov/show/NCT01076127
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers Randomized, Factorial Assignment NCT01071980
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck
Non-specific Pain of the Neck and Shoulder
Comp 522 Adt Jan-09 Feb-10 National Research Centre for the Working Environment, Denmark; University of Copenhagen; University of Southern Denmark
http://ClinicalTrials.gov/show/NCT01071980
Operative or Conservative Treatment for Subacromial Impingment Syndrome? Phase II: RCT (placebo), Efficacy Study NCT00428870
Supervised exercise therapy; Arthroscopic subacromial decompression; diagnostic arthroscopy
Subacromial Impingement Syndrome
Rec 210 Adult Oct-05 Dec-09 Helsinki University http://ClinicalTrials.gov/show/NCT00428870
Shoulder Injury Prevention Program in Swimmers Phase II: RCT (active), Efficacy Study NCT00998777
Shoulder Strengthening
Shoulder Injury Active, NR
48 Adt Sep-09 Nov-09 University of North Carolina, Chapel Hill
http://ClinicalTrials.gov/show/NCT00998777
The Efficacy of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Working Community Phase III: RCT (active), Efficacy Study NCT00551980
Cognitive, Relaxation, and Exercise Therapy
Migraine; Tension Type Headache; Cervical Pain; Shoulder pain
Comp 2895 Child Adt Sen
Oct-07 Nov-09 University of Turin, Italy; Compagnia di San Paolo; Comune di Torino; CPO Piemonte; Regione Piemonte
http://ClinicalTrials.gov/show/NCT00551980
Exercise therapy for shoulder impingement syndrome RCT (active) ISRCTN76701121
Open kinetic chain strengthening; Closed kinetic chain strengthening; range of motion
Chronic shoulder impingement syndrome
Comp 169 N/K Oct-05 Oct-09 Department of Health, UK
http://www.controlled-trials.com/ISRCTN76701121
22
The Shoulder Window of Opportunity Study RCT (active) ISRCTN25817033
Subacromial corticosteroid injection with physiotherapy; physiotherapy alone.
Unilateral shoulder pain; subacromial impingement syndrome
Comp 220 Adt Sen
Mar-06 Mar-09 West Yorkshire Primary Care Research and Development Unit, UK
http://www.controlled-trials.com/ISRCTN25817033
The effect of neck coordination training on sensorimotor function, symptoms and self-rated health and functioning for non-specific neck-shoulder pain RCT ISRCTN92199001
Neck coordination; Strengthening training; Massage; No intervention.
Chronic non-specific neck-shoulder pain
Comp 180 Adt Mar-08 Dec-08 Swedish council for Working Life and Social Research, Sweden
http://www.controlled-trials.com/ISRCTN92199001
Treatment of Myofascial Trigger Points in common shoulder disorders by physical therapy: a randomised controlled trial RCT ISRCTN75722066
Physical therapy + exercise + advice; Wait and see
MSK Chronic shoulder disorders
Comp 104 Adt Sep-07 Sep-08 http://www.controlled-trials.com/ISRCTN75722066
Effects of Eccentric Training for Shoulder Abductors in Subjects With Shoulder Impingement Syndrome Single Group Assignment, Efficacy Study NCT01090271
Isokinetic eccentric training
Shoulder Impingement Syndrome
Comp 25 Adt Oct-07 Jun-08 Universidade Federal de Sao Carlos
http://ClinicalTrials.gov/show/NCT01090271
Device
Transcutaneous Pulse Radiofrequency (PRF) Treatment For Shoulder Pain RCT (placebo) ACTRN12610000171011
Transcutaneous Pulse Radiofrequency (PRF); Inactive PRF
Shoulder pain Not yet Rec
50 Adt Sen
Apr-10 > Oct-10
Frankston Hospital, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=335145
Proposal to Evaluate the Efficacy of the InterX 5000 in the Treatment of Chronic Neck and Shoulder Pain Phase II: RCT (placebo), Efficacy Study NCT00587626
InterX 5000 Treatment; Inactive InterX 5000
Neck Pain; Shoulder Pain; Cervical Pain
Rec 80 Adt Sen
Aug-07 Dec-09 Hamilton Health Sciences; Canadian Memorial Chiropractic College; Neuro Resource Group
http://ClinicalTrials.gov/show/NCT00587626
23
Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Pain, Responders and Non-Responders? Observational: Prospective, Cohort Study NCT00885859
TENStemeco Schwa Medico
Neck Pain; Lower Back Pain; Shoulder Pain
Not yet Rec
62 Adt Sen
Jun-09 Dec-09 Maastricht University Medical Center
http://ClinicalTrials.gov/show/NCT00885859
Efficacy of Interferential Laser Therapy in Shoulder Pain Phase II: RCT (active), Efficacy Study NCT00694538
Interferential Laser therapy
Shoulder MSK Disorders
Comp 200 Adt Sen
Jan-08 Nov-09 Hospital Universitario Ramon y Cajal
http://ClinicalTrials.gov/show/NCT00694538
Randomized Study Comparing Fluoroscopically-Guided Versus Blinded Trochanteric Bursa Injections RCT (active), Efficacy Study NCT00480675
Trochanteric bursa injection under fluoroscopy with depomedrol and bupivacaine; Trochanteric bursa injection with depomedrol and bupivacaine
Bursitis Comp 65 Adt Sen
Mar-07 May-08 Johns Hopkins University
http://ClinicalTrials.gov/show/NCT00480675
Drugs including biologics
Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder Phase IV: RCT (placebo), Efficacy Study NCT01087229
Equimolar oxygen-nitrous oxide mixture
Adhesive Capsulitis
Rec 80 Adt Sen
Mar-10 Apr-12 Centre Hospitalier Universitaire de Nīmes
http://ClinicalTrials.gov/show/NCT01087229
Capsular and Intra-Articular Corticosteroid Injection for Adhesive Capsulitis (Frozen Shoulder): a Randomised, Double Blind, Placebo Controlled Trial RCT (placebo) NCT00840229
Lidocaine; triamcinolone
Adhesive Capsulitis
Not yet Rec
150 Adt Sen
Feb-09 Dec-11 Rikshospitalet HF http://ClinicalTrials.gov/show/NCT00840229
Colchicine Treatment for Chronic Shoulder Pain Related to Calcific Tendonitis RCT (placebo), Efficacy Study NCT00983177
Colchicine; lactose Calcific Tendonitis
Not yet Rec
80 Adt Sen
Mar-10 Oct-11 Bnai Zion Medical Center
http://ClinicalTrials.gov/show/NCT00983177
24
Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder Phase III: RCT (active), Safety/Efficacy Study NCT00876317
Etoricoxib 60 mg; Etoricoxib 90 mg
Soft Tissue Injuries of the Shoulder; Tenosynovitis and Bursitis Affecting the Shoulder
Not yet Rec
300 Adt Sen
Aug-09 Oct-11 Clinica Virgen Milagrosa
http://ClinicalTrials.gov/show/NCT00876317
Comparison of 2 Doses of Corticosteroid Subacromial Injections for the Treatment of Painful Shoulder RCT (dose comparison), Safety/Efficacy Study NCT00914836
Betamethasone Sodium Phosphate 1cc ; Betamethasone Sodium Phosphate 2cc
Tendonitis; Bursitis
Not yet Rec
100 Adt Sen
Jun-09 May-11 HaEmek Medical Center, Israel
http://ClinicalTrials.gov/show/NCT00914836
Timed Release Tablet Prednisone in Polymyalgia Rheumatica Phase II/III: RCT (dose comparison), Efficacy Study NCT00836810
Timed Release Tablet Prednisone; Prednisolone
Polymyalgia Rheumatica
Rec 24 Adt Sen
Oct-09 Feb-11 University Hospitals Bristol NHS Trust
http://ClinicalTrials.gov/show/NCT00836810
Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome Phase II: Single Group Assignment, Safety/Efficacy Study NCT01055444
Heated lidocaine and tetracaine topical patch
Shoulder Impingement Syndrome
Rec 20 Adt Sen
Mar-10 Aug-10 ZARS Pharma Inc. http://ClinicalTrials.gov/show/NCT01055444
Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Glenohumeral Osteoarthritis (OA) Non-Randomized (active), Safety/Efficacy Study NCT00969501
EUFLEXXA Osteoarthritis Active, NR
25 Adt Sen
Aug-09 Jul-10 Georgia Institute for Clinical Research, LLC; Ferring Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00969501
ORTHOVISC Shoulder RCT Phase III: RCT (active), Safety/Efficacy Study NCT00436969
ORTHOVISC Glenohumeral Osteoarthritis
Active, NR
270 Adt Sen
Dec-06 Aug-10 DePuy Mitek http://ClinicalTrials.gov/show/NCT00436969
25
A comparison of the efficacy of corticosteroid and anaesthetic injection into the glenohumeral joint with and without hydrodilatation in patients with frozen shoulders. RCT (active), Efficacy Study ACTRN12610000187044
Corticosteriod and local anaesthetic injection with hydrolation; Corticosteriod and local anaesthetic injection without hydrolation
Frozen Shoulder
Not yet Rec
100 Adt Sen
Mar-10 > Jun-10
Monash Medical Centre, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=335150
Hyaluronic acid versus corticosteroids compared to a placebo in subacromial injections for shoulder cuff impingement RCT (placebo) ISRCTN51511455
Lidocaine + hyaluronic acid; Lidocaine + Triamcinoloni-acetonidum; Lidocaine + saline
Shoulder disorders; complaints of shoulder; painful arc
Comp 159 Adt Sen
Oct-04 Mar-10 Care and Public Health Research Institute, The Netherlands
http://www.controlled-trials.com/ISRCTN51511455
SUPARTZ Versus Placebo in Osteoarthritis of the Shoulder Phase III: RCT (placebo), Safety/Efficacy Study NCT00479687
SUPARTZ; Saline Glenohumeral Osteoarthritis of the Shoulder
Active, NR
300 Adt Sen
May-07 Sep-09 Smith & Nephew, Inc.; Seikagaku Corporation
http://ClinicalTrials.gov/show/NCT00479687
HKT-500 in Adult Patients With Shoulder Pain Phase III: RCT (placebo), Safety/Efficacy Study NCT00680472
HKT-500 & Ketoprofen Topical Patch; Placebo
Pain Comp 368 Adt Sen
Apr-08 Oct-08 Hisamitsu Pharmaceutical Co., Inc.
http://ClinicalTrials.gov/show/NCT00680472
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Phase III: RCT (placebo), Safety/Efficacy Study NCT00426985
Ketoprofen Topical Patch 20%
Tendonitis; Bursitis
Term 330 Adt Sen
Jan-07 Oct-08 Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00426985
26
Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00640939
Diclofenac sodium; Matching Placebo
Upper limb conditions
3
including Rotator Cuff Tendonitis; Bicipital Tendonitis; Subdeltoid Bursitis of the Shoulder; Subacromial Bursitis of the Shoulder
Comp 308 Adt Sen
Dec-07 Jun-08 Cerimon Pharmaceuticals; PPD
http://ClinicalTrials.gov/show/NCT00640939
Other including CAM therapies
Efficacy of Electrotherapy in Subacromial Impingement Syndrome RCT (placebo), Efficacy Study NCT01073956
Medium-wave 448 kHz therapy; Ultrasonic therapy; Inactive electrotherapy
Shoulder Impingement Syndrome
Rec 492 Adt Sen
Feb-10 Jun-12 Fundacio Espai Salut
http://ClinicalTrials.gov/show/NCT01073956
Ultrasound Guided Diagnostic Cervical Medial Branch Block Single Group Assignment, Safety/Efficacy Study NCT00896688
Cervical medial branch blocks using the Quincke spinal needle
Facet Joint Disease; Neck Pain; Shoulder pain
Rec 25 Adt Jan-09 Jan-11 Hamilton Health Sciences
http://ClinicalTrials.gov/show/NCT00896688
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use RCT (active) NCT01050465
Health information prescription
Range of conditions
4
including Back Pain; Fibromyalgia; Knee Pain; Osteoarthritis; Senile Osteoporosis; and Shoulder Pain
Invite 728 Adt Sen
May-09 Dec-10 University of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT01050465
3 Medial Epicondylitis of the Elbow; Lateral Epicondylitis of the Elbow; DeQuervain's Tenosynovitis of the Wrist 4 Acne Vulgaris; Allergic Rhinitis; Anxiety; Asthma; Prostatic Hyperplasia; Bursitis; Chronic Obstructive Pulmonary Disease; Cough; Coronary Artery Disease; Depression; Diabetes Mellitus;
Diarrhea; Gastroesophageal Reflux; Headache; HIV Infections; Hypothyroidism; Hyperlipidemia; Hypertension; Influenza; Sleep Initiation and Maintenance Disorders; Irritable Bowel Syndrome;
27
Stop-rule management in patients with sub-acute chronic pain (WRUEP): a randomized controlled and replicated single case experimental ABCD design. RCT (active) NTR1517
Stop-rule management; Regular rehabilitation
Repetitive strain injury; non-specific work-related upper limb disorders (shoulder, arm elbow, neck, wrist, hand)
Active 12 Adt Nov-08 Nov-10 University Maastricht
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1517
Should the Joint Capsule of the Painful Stiff Shoulder be Ruptured During Intra-articular Hydraulic Distension? Non-Randomized, Parallel Assignment, Efficacy Study NCT00992927
Capsule-preserving Intra-articular Hydraulic Distension; Capsule-rupturing Intra-articular Hydraulic Distension
Adhesive Capsulitis
Rec 50 Adt Sen
Mar-08 Feb-10 Seoul National University Hospital
http://ClinicalTrials.gov/show/NCT00992927
Diaphragmatic Movement Before and After Stellate Gaglion Block : A Ultrasonographic Study Phase IV Primary Purpose: Treatment NCT01054378
M-mode ultrasonography
Head Pain; Neck Pain; Shoulder Pain; Arm Pain; Neural Sensory Hearing Loss
Rec 60 Adt N/K ? Jan-10
Yonsei University http://ClinicalTrials.gov/show/NCT01054378
Effectiveness in the treatment of Subacromial Impingement Syndrome by dry needling of active myofascial trigger points: a randomised controlled trial Observational (on diagnosis); RCT active ISRCTN30907460
Dry needling + Physiotherapy; Physiotherapy alone
Rotator Cuff Tendonitis; Subacromial Impingement Syndrome; Shoulder pain
Comp 132 Adt Sen
Oct-08 Oct-09 Aragones Institute of Health Science, Spain
http://www.controlled-trials.com/ISRCTN30907460
Efficacy Study of Fine Needle Technique on Calcific Tendinitis Phase II: RCT (active), Efficacy Study NCT00506038
Fine needle technique
Tendinitis Term 40 Adt Sen
N/K ? Jun-09
Hadassah Medical Organization
http://ClinicalTrials.gov/show/NCT00506038
Migraine Disorders; Obesity; Obstructive Sleep Apnea; Colonoscopy; Mammography; Sinusitis; Smoking Cessation; Tobacco Use Cessation; Menopause; Urinary Incontinence; Urinary Tract Infection; Vaccination; Vaginitis; Vertigo
28
Development of a Clinical Prediction Rule to Identify Patients With Shoulder Pain Likely to Benefit From Cervicothoracic Manipulation Phase II: Single Group Assignment, Efficacy Study NCT00835302
Cervicothoracic manipulation
Shoulder Pain Active, NR
80 Adt Oct-06 Mar-09 University of Colorado, Denver
http://ClinicalTrials.gov/show/NCT00835302
Ultrasound Evaluation of the Rotator Cable and Associated Structures. NCT00743600
Ultrasound Shoulder Pain Rec N/K Adt Sen
Sep-05 ? Feb-09
University of Michigan
http://ClinicalTrials.gov/show/NCT00743600
Study of the Effect of Neck Treatment on Shoulder Impingement Phase I: Randomized, Parallel Assignment, Efficacy Study NCT00764764
Shoulder treatment; Shoulder and cervical treatment
Shoulder Impingement; Shoulder Pain; Rotator Cuff Tendinitis; Cervical Degenerative Joint Disease
Term 30 Adt Sen
May-08 Dec-08 CAMC Health System
http://ClinicalTrials.gov/show/NCT00764764
Supervised Exercises Compared With Radial Extracorporal Shock Wave Therapy (rESWT) in Patients With SIS Phase III: RCT (active), Efficacy Study NCT00653081
Supervised Exercises; Radial Extracorporeal Shockwave Therapy
Shoulder Pain Active, NR
104 Adt Sen
Jul-06 Dec-08 Ullevaal University Hospital; South Eastern Area Health Service; University of Oslo
http://ClinicalTrials.gov/show/NCT00653081
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow Non-Randomized (Historical), Efficacy Study NCT00634608
Health Information Prescription - MedlinePlus link
Various conditions including
5 Back
Pain; Osteoporosis (Senile) and Shoulder Pain
Active, NR
400 Adt Sen
Feb-08 Oct-08 University of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT00634608
5 Allergic Rhinitis; Asthma; Benign Prostatic Hypertrophy; Bursitis; Depression; Anxiety; Diabetes Mellitus; Esophageal Reflux; HIV Infections; Hyperlipidemia; Hypertension; Insomnia; Irritable
Bowel Syndrome; Obesity; Sinusitis; Symptomatic Menopause; Urinary Incontinence; Urinary Tract Infection; Vaginitis
29
Miscellaneous observational studies
Mechanical Load on the Shoulders While Carrying a Backpack- Towards a Knowledge-Based Backpack Design Prospective, Case-Only study NCT01066975
Healthy; Strain Not yet Rec
5 Adt
M-only
Feb-10 Apr-11 Sheba Medical Center; Tel Aviv University
http://ClinicalTrials.gov/show/NCT01066975
Prevalence of Impaired Glucose Tolerance (IGT) in Patients With Frozen Shoulder Cross-sectional, Case-Crossover study NCT00926094
Frozen Shoulder; Impairment Glucose Tolerance
Rec 50 Adt Apr-09 Jun-10 Hadassah Medical Organization
http://ClinicalTrials.gov/show/NCT00926094
Biopsychosocial Factors' Influence on Shoulder Pain Prospective NCT00187863
Shoulder pain; Pain perception; Pain Assessment
Active, NR
350 Adt Sen
May-05 ? May-08
University of Florida http://ClinicalTrials.gov/show/NCT00187863
A4: NECK PAIN
Title Phases: trial design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
The Value of Traction in the Treatment of Cervical Radiculopathy Phase III: RCT (active) NCT00979108
Physical therapy rehabilitation
Radiculopathy; Neck Pain; Spinal Diseases; MSK Diseases; Neuromuscular Diseases; Intervertebral Disk Displacement
Rec 192 Adt Sen
Jul-09 Jul-12 Intermountain Health Care, Inc.; University of Utah; Wilford Hall Medical Center; Empi, A DJO Company
http://ClinicalTrials.gov/show/NCT00979108
30
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population Phase III: Single Group Assignment, Efficacy Study NCT01050972
Cognitive, Relaxation and Exercise Therapy
Migraine; Tension Type Headache; Cervical Pain
Rec 15000 Child Adt Sen
Jun-09 Nov-11 University of Turin, Italy; Fondazione CRT, Torino; Comune di Torino; Regione Piemonte
http://ClinicalTrials.gov/show/NCT01050972
Neck Pain in Danish Military Pilots and Flight Crew Randomized, Parallel Assignment NCT00812903
Exercise; no intervention
Neck Pain Rec 150 Adt Sen
Mar-09 Jul-11 University of Southern Denmark; Odense University Hospital; Danish Defence; Royal Danish Air Force
http://ClinicalTrials.gov/show/NCT00812903
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck RCT (dose comparison), Efficacy Study NCT01027390
Physical training exercise
MSK Disorders; Neck pain; Shoulder pain
Invite 800 Adt Sen
Jan-10 Dec-10 University of Southern Denmark; National Research Centre for the Working Environment, Denmark; University of Copenhagen
http://ClinicalTrials.gov/show/NCT01027390
Physical activity to prevent deterioration in cleaners RCT ISRCTN96241850
Physical coordination training; Cognitive behavioural training; Health check
Shoulder pain; Neck pain
Active 400 Adt Aug-07 Dec-10 The Ministry of Culture Committee on Sports Research
http://www.controlled-trials.com/ISRCTN96241850
Effect of Kettlebell Training on Musculoskeletal and Cardiovascular Health Randomized, Factorial Assignment NCT01076127
Ketllebell training; Control
MSK Disorders; Neck pain; Shoulder pain; Back pain
Active, NR
40 Adt Mar-10 Aug-10 National Research Centre for the Working Environment, Denmark
http://ClinicalTrials.gov/show/NCT01076127
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers Randomized, Factorial Assignment NCT01071980
Work Place Adjusted Intelligent Physical Exercise Reducing MSK Pain in Shoulder and Neck
Non-specific Pain of the Neck and Shoulder
Comp 522 Adt Jan-09 Feb-10 National Research Centre for the Working Environment, Denmark; University of Copenhagen; University of Southern Denmark
http://ClinicalTrials.gov/show/NCT01071980
31
Effect of Neck Strength Training on Health-related Quality of Life in Females With Neck Pain Randomized, Crossover Assignment NCT01057836
Neck endurance training; Stretching
Neck Pain Comp 180 Adt
F -only
N/K ? Jan-10
Jyväskylä Central Hospital
http://ClinicalTrials.gov/show/NCT01057836
The efficacy of a cognitive and physical intervention to reduce head & muscle pain in a working community Phase III: RCT, Efficacy Study NCT00551980
Cognitive, Relaxation and Exercise Therapy; No intervention
Migraine; Tension Type Headache; Cervical Pain
Comp 2895 Child Adt Sen
Oct-07 Nov-09 University of Turin, Italy
http://ClinicalTrials.gov/show/NCT00551980
Qigong and Exercise for Neck Pain in Adults (QENA) Randomized, Parallel Assignment NCT00615732
Qigong; Exercise therapy
Chronic Neck Pain
Comp 120 Adt Mar-08 Oct-09 Charite University, Berlin, Germany
http://ClinicalTrials.gov/show/NCT00615732
The effectiveness of Global Postural Reeducation Method (GPR) and conventional kinesiotherapy on pain, quality of life and functional disability in subjects with chronic spine pain. RCT (active) ACTRN12609000962235
Global Postural re-education; Kinesiology
Spine, Chronic pain; Chronic neck pain; chronic low back pain
Active NR
150 Adt Oct-07 > Aug-09
Universidade Federal de Sao Paulo
http://www.anzctr.org.au/trial_view.aspx?ID=308378
A randomised clinical trial to determine the effects on the neck range of movement of SNAGs versus exercise RCT ISRCTN39100909
Sustained natural apophysical glide (SNAG); Exercise
MSK Diseases; Neck problems
Comp 40 N/K Feb-07 Aug-09 Department of Health, UK
http://www.controlled-trials.com/ISRCTN39100909
The effect of neck coordination training on sensorimotor function, symptoms and self-rated health and functioning for non-specific neck-shoulder pain RCT ISRCTN92199001
Neck coordination; Strengthening training; Massage; No intervention.
Chronic non-specific neck-shoulder pain
Comp 180 Adt Mar-08 Dec-08 Swedish council for Working Life and Social Research, Sweden
http://www.controlled-trials.com/ISRCTN92199001
Participatory ergonomics for the primary prevention of back and neck pain: a cost-effectiveness study RCT (placebo) ISRCTN27472278
Participative ergonomic program
Back pain; Neck pain; prevention
Comp 3668 Adt Sen
Oct-07 Oct-08 VU University Medical Centre, The Netherlands
http://www.controlled-trials.com/ISRCTN27472278
32
Device
Proposal to Evaluate the Efficacy of the InterX 5000 in the Treatment of Chronic Neck and Shoulder Pain Phase II: RCT (placebo), Efficacy Study NCT00587626
InterX 5000 Treatment; Inactive InterX 5000
Neck Pain; Shoulder Pain; Cervical Pain
Rec 80 Adt Sen
Aug-07 Dec-09 Hamilton Health Sciences; Canadian Memorial Chiropractic College; Neuro Resource Group
http://ClinicalTrials.gov/show/NCT00587626
Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Pain, Responders and Non-Responders? Observational: Prospective, Cohort study NCT00885859
TENStemeco Schwa Medico
Neck Pain; Lower Back Pain; Shoulder Pain
Not yet Rec
62 Adt Sen
Jun-09 Dec-09 Maastricht University Medical Center
http://ClinicalTrials.gov/show/NCT00885859
Electroacupuncture for Chronic Neck Pain Phase II: RCT (placebo), Efficacy Study NCT00826215
Electro-acupuncture; Sham laser acupuncture
Neck Pain Active, NR
200 Adt Sen
Mar-07 Feb-09 Hong Kong Baptist University; The Hong Kong Polytechnic University
http://ClinicalTrials.gov/show/NCT00826215
Drugs including biologics
Trial to Evaluate the Efficacy of Topical Capsaicin to Reduce Pain and Improve Health-related Quality of Life in Adults With Chronic Myofascial Neck Pain Phase II: RCT (placebo), Efficacy Study NCT00795106
Capsaicin; Placebo Myofascial Pain Syndrome
Not yet Rec
60 Adt Sen
Nov-09 Nov-10 Stamford Hospital http://ClinicalTrials.gov/show/NCT00795106
Pregabalin and Radicular Pain Study (PARPS) Phase IV: Single Group Assignment NCT01061697
Pregabalin Cervical Spondylosis; Cervical Spondylotic Myelopathy; Cervical Spondylotic Radiculopathy
Active, NR
50 Adt Sen
Jan-08 Apr-10 Singapore General Hospital; Pfizer
http://ClinicalTrials.gov/show/NCT01061697
33
Oral Dexamethasone for the Treatment of Cervical Radiculopathy Phase II: RCT (placebo), Efficacy Study NCT00308594
Dexa-methasone; placebo
Cervical Radiculopathy
Term 100 Adt Nov-06 Nov-08 University of Manitoba
http://ClinicalTrials.gov/show/NCT00308594
Other including CAM therapies
Chiropractic and Exercise Management of Spinal Dysfunction in Seniors Phase II/III: RCT (active) NCT01057706
Chiropractic; Behavioral: exercise
Neck Disability; Back Disability
Rec 300 Adt Sen
Jan-10 Aug-15 Northwestern Health Sciences University; Health Resources and Services Administration (HRSA)
http://ClinicalTrials.gov/show/NCT01057706
Effectiveness of a general neck exercise program, of acupuncture or of repetitive low-energy shockwave therapy for chronic neck disorders RCT (active) ISRCTN99496264
General neck exercise program; acupuncture; low-energy shockwave thterapy
Neck disorders; Neck pain
Active 350 Adt Sen
Mar-10 Dec-12 German and International Society for Extracorporeal Shock Wave Therapy, Germay
http://www.controlled-trials.com/ISRCTN99496264
The effect of various combinations of naprapathic manual therapy for patients with neck pain and/or back pain RCT (active) ISRCTN92249294
Naprapathic manual therapy; Naprapathic manual therapy excluding spinal manipulation; Naprapathic manual therapy except stretching
Non-specific back pain; Non-specific neck pain
Active 1050 Adt Mar-10 Dec-12 The Scandinavian College of Naprapathic Manual Medicine
http://www.controlled-trials.com/ISRCTN92249294
Treatment of Chronic Thoracic and Neck and Upper Extremity Pain RCT (dose comparison), Safety/Efficacy Study NCT01071369
Thoracic and cervical interlaminar epidural injections; Drug: Xylocaine; Celestone
Back Pain; Neck Pain
Active, NR
240 Adt Sen
Feb-08 Feb-12 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01071369
Effectiveness of Manual Therapy in Patients With Neck Pain. RCT (active), Efficacy Study NCT00713843 & NTR1208
Manual Therapy Utrecht; Physical Therapy
Neck Pain Rec 180 Adt Sen
Sep-08 Dec-11 Radboud University; Stichting Garantiefonds Spaarneland, The Netherlands
http://ClinicalTrials.gov/show/NCT00713843 also http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1208
34
Comparing Two Different Cervical Collars for the Treatment in Patient With Cervical Radiculopathy and Radicular Pain RCT (active), Efficacy Study NCT00880828
FIR cervical collar + Acetaminophen; Conservative cervical collar + Acetaminophen; Drug: Acetaminophen only
Cervical Radiculopathy; Radicular Pain; Acute Neck Pain; Cervico-brachial Pain
Not yet Rec
72 Adt Sen
Aug-10 Oct-11 Taipei Medical University WanFang Hospital
http://ClinicalTrials.gov/show/NCT00880828
Ultrasound Guided Diagnostic Cervical Medial Branch Block Single Group Assignment, Efficacy Study NCT00896688
Cervical medial branch blocks using the Quincke spinal needle
Facet Joint Disease; Neck Pain
Rec 25 Adt Jan-09 Jan-11 Hamilton Health Sciences
http://ClinicalTrials.gov/show/NCT00896688
Stop-rule management in patients with sub-acute chronic pain (WRUEP): a randomized controlled and replicated single case experimental ABCD design. RCT (active) NTR1517
Stop-rule management; Regular rehabilitation
Repetitive strain injury; non-specific work-related upper limb disorders (shoulder, arm elbow, neck, wrist, hand)
Active 12 Adt Nov-08 Nov-10 University Maastricht
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1517
Chiropractic for Back and Neck Pain in an Emergency Department Setting Phase I/II: RCT (placebo), Efficacy Study NCT00964717
Real Chiropractic; Sham Chiropractic
Back Pain; Neck Pain; Anxiety
Rec 90 Adt May-09
May-10
Assaf-Harofeh Medical Center
http://ClinicalTrials.gov/show/NCT00964717
Electroacupuncture and Laser Therapy on Neck Pain Randomized, Parallel Assignment NCT00618878
Electro-acupuncture; Laser Therapy
Chronic Neck Pain
Rec 20 Adt Sen
Oct-08 Feb-10 Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00618878
Acupuncture for Back and Neck Pain in an Emergency Room Setting Phase I/II: RCT (placebo), Efficacy Study NCT00859365
Real Acupuncture; Placebo Acupuncture; No intervention
Back Pain; Neck Pain; Anxiety; Range of Motion
Rec 90 Adt Jan-09 Jan-10 Assaf-Harofeh Medical Center
http://ClinicalTrials.gov/show/NCT00859365
The use of pulsed radiofrequency treatment into the atlantoaxial joint for the management of refractory head and neck pain. Single Group Assignment NTR2034
Pulsed radiofrequency into lateral atlantoaxial joint
Neck pain; Facialgie; Suboccipital pain; irradiating pain
N/K 100 Adt Sen
Jan-08 Jan-10 Orbis Medical Centrum
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2034
35
Cervical Epidural Pressure Measurement Randomized, Parallel Assignment NCT01009385
Cervical epidural steroid injection; Epidural pressure measurement
Head Pain; Neck Pain; Upper Extremity Pain
Invite 30 Adt Sen
Oct-09 Nov-09 Seoul National University Bundang Hospital
http://ClinicalTrials.gov/show/NCT01009385
The Specificity of Cervical Facet Medial Branch Blocks RCT (dose comparison) NCT00613340
Cervical medial branch blocks
Neck Pain; Cervical Facet Arthropathy
Comp 20 Adt Sen
Jan-08 Apr-09 Johns Hopkins University; Army Regional Anesthesia and Pain Management Initiative
http://ClinicalTrials.gov/show/NCT00613340
Relative Effectiveness and Adverse Effects of Cervical Manipulation, Mobilisation and the Activator Instrument in Patients With Sub-acute Non-specific Neck Pain: a Pragmatic Randomised Trial Randomized, Parallel Assignment, Safety/Efficacy Study NCT01029951
Manipulation; Mobilisation; Device: Activator instrument
Neck Pain Comp 47 Adt Jan-07 Mar-09 Anglo-European College of Chiropractic; European Chiropractors Union; National Institute for Chiropractic Research
http://ClinicalTrials.gov/show/NCT01029951
Cross-Disciplinary Workplace Intervention Strategy for Chronic Musculoskeletal Disorders RCT (active), Efficacy Study NCT00369135
Combined intervention
Back Pain; Neck Pain; MSK Abnormalities
Rec 120 Adt Mar-06 Feb-09 Institut Universitaire Romand de Sante au Travail
http://ClinicalTrials.gov/show/NCT00369135
Preventive Care of Chronic Cervical Pain and Disabilities RCT (active) NCT00566930
Spinal manipulation; Spinal manipulation + exercises
Neck Pain Rec 115 Adt Oct-07 Jan-09 Université du Québec à Trois-Rivière; Foundation for Chiropractic Education and Research (FCER)
http://ClinicalTrials.gov/show/NCT00566930
Patients With Neck Pain Likely to Benefit From Thoracic Spine Thrust Mobilization Phase I: Randomized, Parallel Assignment NCT00504686
Manual therapy; Exercise
Neck Pain Comp 140 Adt Jan-07 Dec-08 Franklin Pierce University; Newton-Wellesley Hospital
http://ClinicalTrials.gov/show/NCT00504686
36
The Effect of Chiropractic Manipulation on Spine-related Pain and Balance in Older Adults Single Group Assignment, Efficacy Study NCT00497718
Chiropractic Manipulation
MSK Equilibrium; Back Pain; Neck pain
Comp 75 Adt Sen
Feb-07 Dec-08 Cleveland Chiropractic College
http://ClinicalTrials.gov/show/NCT00497718
Acupuncture for chronic neck pain: a pilot for a randomised controlled trial RCT ISRCTN06223266
Acupuncture + usual GP care; usual GP care
Chronic Neck pain
Comp 30 Adt Sen
May-05
Sep-08 University of York, UK
http://www.controlled-trials.com/ISRCTN06223266
Manual Therapy, Exercise and Traction for Patients With Cervical Radiculopathy: A RCT RCT (placebo), Efficacy Study NCT00695006
Traction; Sham Traction
Cervical Radiculopathy
Active, NR
81 Adt Sen
Sep-06 Jul-08 Rocky Mountain University of Health Professions
http://ClinicalTrials.gov/show/NCT00695006
Chiropractic and Exercise for Seniors With Neck Pain Phase II: RCT (active), Efficacy Study NCT00269308
Chiropractic Manual treatment + home exercise; Supervised rehabilitative exercise + home exercise; Home exercise
Neck Pain Active, NR
240 Adt Sen
Oct-03 Jul-08 Northwestern Health Sciences University; Health Resources and Services Administration (HRSA); Berman Center for Outcomes and Clinical Research
http://ClinicalTrials.gov/show/NCT00269308
Diaphragmatic Movement Before and After Stellate Gaglion Block : A Ultrasonographic Study Phase IV NCT01054378
M-mode ultrasonography
Head Pain; Neck Pain; Shoulder Pain; Arm Pain; Neural Sensory Hearing Loss
Rec 60 Adt N/K ? Jan-10
Yonsei University http://ClinicalTrials.gov/show/NCT01054378
Miscellaneous observational studies
Association Between Neck Pain and Quality of Sleep Prospective NCT00907049
Chronic Neck Pain; Disability
Rec 420 Child Adt Sen
Sep-09 Sep-11 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00907049
Validation of a Novel Sham Cervical Spinal Manipulation Procedure NCT00978094
Chronic Neck Pain
Rec 80 Adt Feb-09 Jun-11 Canadian Memorial Chiropractic College
http://ClinicalTrials.gov/show/NCT00978094
37
The Influence of Coping Strategies and Catastrophizing on Patients With Back and Neck Pain Prospective, Cohort Study NCT00502333
Back Pain; Neck Pain
Rec 1400 Adt Sen
Nov-06 Dec-10 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00502333
Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study Cohort Study NCT00510757
Cervicogenic Headache; Neck Pain; Whiplash; Kyphotic and Reversed Cervical Curves
Rec 200 Adt Jun-07 Jun-10 Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00510757
Unilateral Blindness/ Unilateral Deafness-Relation to Neck Pain Cross-sectional, Case Control NCT00589407
Neck Pain; Unilateral Blindness; Unilateral Deafness
Susp 300 ChildAdt
Oct-05 Oct-09 Hadassah Medical Organization
http://ClinicalTrials.gov/show/NCT00589407
Cervicocephalic kinesthetic sensibility and postural balance in patients with non-traumatic chronic neck pain ISRCTN96873990
Mechanical non-traumatic chronic neck pain
Comp 30 Adt Oct-08 Nov-08 Scandinavian College of Chiropractic (Sweden)
http://www.controlled-trials.com/ISRCTN96873990
The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time NCT00042276
Neck Pain Rec 100 Adt Jul-02 ? Apr-10
National Institutes of Health Clinical Center (CC)
http://ClinicalTrials.gov/show/NCT00042276
38
A5: BACK PAIN
Title Phases: trial design (control) CT ID
Interventions Conditions
Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Interactive Voice Response (IVR)-Based Treatment for Chronic Low Back Pain Randomized, Parallel Assignment, Efficacy Study NCT01025752
Face to face CBT; IVR based CBT
Chronic Low Back Pain
Not yet Rec
230 Adt Sen
Apr-10 Jan-14 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT01025752
Effect of Interventions in Return to Work for Patients With Neck and Low Back Pain RCT (active) NCT00840697
Exercises and work related rehabilitation
Low Back Pain Not yet Rec
600 Adt Aug-09 Apr-13 Ullevaal Uni. Hosp; The Research Council of Norway
http://ClinicalTrials.gov/show/NCT00840697
An Educational and Exercise Program as Secondary Prevention of Recurrent Lower Back Pain in Healthcare Workers RCT (placebo), Efficacy Study NCT00782925
Educational program; Exercise program; Self-led exercises
Acute Low Back Pain
Rec 650 Adt Oct-08 Dec-12 Hospices Civils de Lyon
http://ClinicalTrials.gov/show/NCT00782925
Effectiveness of tailored pain management in patients with chronic back pain RCT ISRCTN25592008
Graded activity exercise + individual CBT; strengthening + stretching exercises + group CBT
Chronic non-specific back pain
Active 120 Adt Sen
Jan-09 Dec-12 Zurzach Rehabilitation Foundation, SPA, Switzerland
http://www.controlled-trials.com/ISRCTN25592008
Ibedrift - A Trial Comparing a New Approach to Musculoskeletal Pain Consisting of Education and Peer Involvement to Treatment as Usual Phase II/ III: Randomized, Parallel Assignment, Efficacy Study NCT00741650
Information and Peer advisor; Information, peer advisor and fast referral
MSK Pain; Low back pain
Active NR
5000 Adt Sen
Sep-08 Dec-12 UNIFOB A/S; RiksHospet HF
http://ClinicalTrials.gov/show/NCT00741650
39
Spinal Cord Stimulator Implant Study RCT (placebo), Efficacy Study NCT00887419
Coping Skills Training; Education
Back Pain Rec 128 Adt Sen
Nov-08 Nov-12 Duke Uni.; Uni. of Michigan
http://ClinicalTrials.gov/show/NCT00887419
Biopsychosocial Education and Chronic Low Back Pain Randomized, Parallel Assignment NCT00600197
Back school Chronic Low Back Pain
Active NR
170 Adt Sen
Jul-08 Sep-12 Tehran Uni. of Medical Sciences
http://ClinicalTrials.gov/show/NCT00600197
Cognitive Interventions and Nutritional Supplementation for Patients With Long-lasting Back Pain Phase I: RCT (placebo), Efficacy Study NCT00463970
Brief Intervention; CBT; Dietary Supplement: Seal oil; Soy oil
Chronic Low Back Pain
Rec 600 Adt Feb-08 Aug-12 UNIFOB A/S; The Research Council of Norway; Uni. of Bergen; Haukeland Uni. Hosp
http://ClinicalTrials.gov/show/NCT00463970
The Value of Traction in Treatment of Lumbar Radiculopathy Phase III RCT (active), Efficacy Study NCT00942227
Physical therapy rehabilitation
Sciatica; Radiculopathy; Spinal Diseases; MSK Diseases; Neuromuscular Diseases; Intervertebral Disk Displacement
Rec 120 Adt Jul-09 Jul-12 Intermountain Health Care, Inc.; Uni. of Utah; Wilford Hall Medical Center; Empi, A DJO Company
http://ClinicalTrials.gov/show/NCT00942227
Rehabilitation of Patients With Modic Changes in the Lumbar Spine Randomized, Parallel Assignment NCT00454792
Exercise; Restitution
Low Back Pain Active NR
100 Adt Mar-07 Jun-12 The Back Research Center, Denmark
http://ClinicalTrials.gov/show/NCT00454792
Improving Patient Choice in Treating Low Back Pain RCT (active) ISRCTN46035546
Physiotherapist trained on informed shared decision making; Physiotherapist not trained on informed shared decision making
Low back pain Active 150 Adt Sen
Apr-10 Mar-12 University of Warwick, UK
http://www.controlled-trials.com/ISRCTN46035546
The COPE LBP trial: Cognitive Patient Education for Low Back Pain RCT (active) ISRCTN04323845
Cognitive intervention; usual care
Non-specific low back pain
Active 300 Adt Jan-09 Dec-11 Oslo University Hospital
http://www.controlled-trials.com/ISRCTN04323845
40
Veterans Walk to Beat Back Pain RCT (active), Efficacy Study NCT00694018
Internet mediated enhanced pedometer intervention; Education and standard care
Back Pain Rec 260 Adt Sen
May-09
Sep-11 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00694018
Work Related Rehabilitation in Patients With Low Back Pain Phase III: RCT (active), Efficacy Study NCT00526604
Work related rehabilitation
Low Back Pain Wtdwn 260 Adt Jan-08 Sep-11 Ullevaal Uni. Hosp http://ClinicalTrials.gov/show/NCT00526604
Treatment of Low Back Pain in Patients With End-stage Renal Disease on Hemodialysis Phase III: RCT (active), Efficacy Study NCT01095783
Physio-therapeutic intervention; Control
Chronic Low Back Pain
Rec 80 Adt Sen
Mar-09 Jul-11 Federal Uni. of Sao Paulo
http://ClinicalTrials.gov/show/NCT01095783
Effectiveness of Group GDS and Individual GDS for Treatment of Low Back Pain in Primary Care RCT (active), Safety/Efficacy Study NCT01060280
Education on active management; Group GDS physiotherapy
Subacute Nonspecific Low Back Pain; Chronic Nonspecific Low Back Pain
Not yet Rec
462 Adt May-10
Jun-11 Kovacs Foundation http://ClinicalTrials.gov/show/NCT01060280
A Bio-psycho-social Exercise Program (RÜCKGEWINN) for Chronic Low Back Pain in Rehabilitation Aftercare Phase II/III RCT (active), Efficacy Study NCT01070849
Educational booklet;IRENA; RÜCKGEWINN
Low Back Pain Rec 456 Adt Nov-09 May-11
Uni. of Erlangen-Nürnberg Medical School; German Federal Pension Fund
http://ClinicalTrials.gov/show/NCT01070849
Recurrent Low Back Pain:Linking Mechanisms to Outcomes Efficacy Study NCT01085604
Core Stabilization Low Back Pain, Mechanical
Rec 80 Adt Aug-09 May-11
Drexel Uni.; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
http://ClinicalTrials.gov/show/NCT01085604
41
Efficacy of Tailored Cognitive-Behavioral Therapy for Chronic Back Pain RCT (active), Efficacy Study NCT00108381
Tailored CBT; Standard care
Back Pain Active NR
162 Adt Sen
Jan-04 Apr-11 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00108381
Evaluation of a risk tailored intervention among low back pain patients in primary care RCT (active) ISRCTN68205910
Risk tailored intervention; usual care
Non-specific low back pain
Active 1200 Adt Mar-09 Mar-11 German Federal ministry of Education and Research
http://www.controlled-trials.com/ISRCTN68205910
The Effect of Two Short Education Programs for Nonspecific Low Back Pain in a Workers' Health Care Organization RCT (active), Efficacy Study NCT00665821
Classic back pain prevention education and CBT; General health education
Low Back Pain Term 657 Adt Sep-08 Feb-11 Kovacs Foundation; Hosp Laboral SOLIMAT
http://ClinicalTrials.gov/show/NCT00665821
High(Deadlift) Versus Low Intensity Motor Control Exercises on Low Back Pain Phase II: RCT (active), Efficacy Study NCT01061632
High intensity motor control exercise (deadlift); Low intensity motor control exercise
Low Back Pain Active NR
70 Adt Jan-10 Jan-11 Luleå Tekniska Universitet
http://ClinicalTrials.gov/show/NCT01061632
Qigong and Exercise Therapy for Low Back Pain in Adults RCT (active), Safety/Efficacy Study NCT00993980
Qigong; Exercise therapy
Low Back Pain Not yet Rec
120 Adt Oct-09 Jan-11 Charite Uni., Berlin, Germany
http://ClinicalTrials.gov/show/NCT00993980
Working Well With Back Pain (Feasibility RCT of Vocational Rehabilitation) Phase I/II: RCT (active), Efficacy Study NCT00817882
Individually targeted vocational rehabilitation; Routine back pain rehabilitation
Low Back Pain Not yet Rec
50 Child Adt Sen
Mar-09 Dec-10 Uni. of Nottingham; Arthritis Research Campaign
http://ClinicalTrials.gov/show/NCT00817882
Treatment for Nonspecific Low Back Pain in Primary Care: a Trial on Different Health Education Booklets Phase II: RCT (placebo), Efficacy Study NCT00361556
The Back Book; The Back Guide; General health book
Low Back Pain Rec 240 Adt Sen
Oct-05 Dec-10 Kovacs Foundation; Spanish Back Pain Research Network (REIDE)
http://ClinicalTrials.gov/show/NCT00361556
42
Supervised Walking In comparison to Fitness Training for back pain RCT (active) ISRCTN17592092
Supervised walking; Fitness training
Chronic low back pain
Active 246 Adt Oct-08 Oct-10 Health Research Board, Ireland
http://www.controlled-trials.com/ISRCTN17592092
The Step Back Up trial: the feasibility of a pedometer driven walking programme for chronic low back pain RCT (active) ISRCTN67030896
Walking; Education Chronic low back pain
Active 50 Adt Sep-09 Sep-10 University of Ulster, UK
http://www.controlled-trials.com/ISRCTN67030896
Treatment of Veterans With Chronic Low Back Pain RCT (active), Efficacy Study NCT00361270
EMG Biofeedback without hypnotic suggestion; Home practice with hypnosis CDs; Therapist-guided hypnosis; Therapist-guided hypnosis + home practice with hypnosis CDs
Low Back Pain, Recurrent
Active NR
162 Adt Sen
Oct-06 Sep-10 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00361270
Telehealth Outreach for Chronic Back Pain Phase I/ II: RCT (active), Efficacy Study NCT00608530
CBT; Rogerian psychotherapy
Pain; Back Pain Rec 130 Adt Sen
Mar-08 Sep-10 Department of Veterans Affairs; Uni. of California, San Diego
http://ClinicalTrials.gov/show/NCT00608530
Managing Non-acute Low Back Symptoms in Occupational Health: Two Trials Phase III: Randomized, Factorial Assignment, Efficacy Study NCT00908102
Back book; Back book and Advice; Physical Medicine Unit; Documentation based care
Low Back Pain, Recurrent; Low Back Pain
Active NR
505 Adt Sep-01 Sep-10 Helsinki Uni.; Uni. of Oulu; Juho Vainio Foundation; Finnish Cultural Foundation; Yrjo Jahnsson Foundation
http://ClinicalTrials.gov/show/NCT00908102
Effect of Yoga Vs. Stretching on Chronic Back Pain Phase II: RCT (active), Safety/Efficacy Study NCT00447668
Yoga; Exercise; Self-care book recommendations
Chronic Non-specific Low Back Pain
Active NR
210 Adt Mar-07 Aug-10 Group Health Cooperative; National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00447668
43
Effect of Kettlebell Training on Musculoskeletal and Cardiovascular Health Randomized, Factorial Assignment NCT01076127
Ketllebell training; Control
MSK Disorders: Neck, Shoulder and Back pain
Active NR
40 Adt Mar-10 Aug-10 National Research Centre for the Working Environment, Denmark
http://ClinicalTrials.gov/show/NCT01076127
Specific Treatment Of Problems of the Spine (STOPS) Trials: Manual Therapy Group RCT (active) ACTRN12609000334202
Physiotherapy including manual therapy; Physiotherapy advice
Subacute low back pain with or without leg pain
N/K 150 Adt Jul-09 > Jul-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=83864
Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE) RCT (active), Efficacy Study NCT00386243
CBT; Pain self-management program; Drug: Co-Analgesic Therapy; Opioid Analgesics
Low Back Pain; Pain; Pain, Intractable
Rec 300 Adt Sen
Dec-07 Jul-10 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00386243
Specific Treatment Of Problems of the Spine (STOPS) Trials: Specific physiotherapy treatment and advice versus advice alone for sub-acute reducible discogenic low back pain: a randomised controlled trial. RCT (active) ACTRN12609000343202
Physiotherapy and physiotherapy advice; Physiotherapy advice alone
Reducible discogenic low back pain
N/K 124 Adt Jun-09 > Jun-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=83878
Improving the effectiveness of primary care for low back pain: the Sub-grouping for Targeted Treatment (STarT Back) trial RCT ISRCTN37113406
Targeted physiotherapy program; usual care
Non-specific low back pain
Active 800 Adt Sen
Apr-07 Jun-10 Keele University, UK
http://www.controlled-trials.com/ISRCTN37113406
Specific Treatment Of Problems of the Spine (STOPS) Trials: Effect of advice versus physiotherapy functional restoration on pain and function for people with multi-factorial persistent low back pain. RCT (active) ACTRN12609000293268
Physiotherapy functional restoration; Physiotherapy advice alone
Multi-factorial persistent low back pain
N/K 150 Adt May-09
> May-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=83875
Early physiotherapy for acute low back pain RCT (active) ISRCTN19037867
Physiotherapy + usual care; usual care
Acute low back pain
Comp 50 Adt Oct-06 May-10
University of Southampton, UK
http://www.controlled-trials.com/ISRCTN19037867
44
Illness perceptions and activity limitations in chronic low back pain. RCT ISRCTN35108886
Cognitive treatment; Waiting list control
Chronic non-specific low back pain
Comp 135 Adt Sen
Dec-04 May-10
Netherlands Organisation for Health Research & Development
http://www.controlled-trials.com/ISRCTN35108886
Specific Treatment Of Problems of the Spine (STOPS) Trials: Effects of advice versus physiotherapy functional restoration on pain and function for people with lumbar disc herniation and associated radiculopathy RCT (active) ACTRN12609000205235
Physiotherapy functional restoration including advice; Physiotherapy advice
Lumbar disc herniation with associated radiculopathy
N/K 150 Adt Jul-09 > Jul-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=83678
Pragmatic randomised controlled trial of yoga for the treatment of chronic low back pain RCT (active) ISRCTN81079604
Yoga; usual care Chronic Low back pain
Comp 262 Adt Apr-07 Mar-10 University of York, UK
http://www.controlled-trials.com/ISRCTN81079604
Classification-Directed Treatment of Low Back Pain Phase I: Randomized, Parallel Assignment, Efficacy Study NCT00802724
Classification-directed treatment; Non-specific treatment
Low Back Pain Rec 100 Adt Jan-07 Mar-10 Eunice Kennedy Shriver National Institute of Child Health & Human Development; Washington Uni. School of Medicine
http://ClinicalTrials.gov/show/NCT00802724
Physiotherapy for sleep disturbance in chronic low back pain trial RCT ISRCTN54009836
Supervised exercise class; usual physiotherapy; walking programme
Chronic low back pain
Comp 60 Adt Sen
Oct-08 Feb-10 Health Research Board, Ireland
http://www.controlled-trials.com/ISRCTN54009836
Prevention of Low Back Pain in the Military RCT (active), Safety/Efficacy Study NCT00373009
Traditional military training; Core stabilization military training; Psychosocial education military training; Combined military training
Low Back Pain Active NR
2700 Adt Feb-07 Feb-10 Uni. of Florida; Brooke Army Medical Center
http://ClinicalTrials.gov/show/NCT00373009
45
Cost-effectiveness of exercise programmes to prevent low back pain and falls (I): low-frequency vibratory exercise RCT ISRCTN31946666
Low-frequency vibratory exercise; Usual care
Chronic low back pain
Comp 60 Adt Sen
Sep-09 Jan-10 University of Extremadura, Spain
http://www.controlled-trials.com/ISRCTN31946666
Specific Treatment of Problems of the Spine (STOPS) Trials: Effects of specific physiotherapy functional restoration and advice versus advice alone for people with sub-acute non-reducible discogenic low back pain. RCT (active) ACTRN12609000412235
Physiotherapy and physiotherapy advice; Physiotherapy advice alone
Lumbar non-reducible discogenic pain
N/K 150 Adt Jun-09 > Dec-09
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=083887
Specific Treatment Of Problems of the Spine (STOPS) Trials RCT (active) ACTRN12609000834257
Physiotherapy and physiotherapy advice; Physiotherapy advice alone
Low back pain with or without sciatica
N/K 200 Adt Jun-09 > Dec-09
Health Networks Australia/ Lifecare Health; La Trobe University
http://www.anzctr.org.au/trial_view.aspx?ID=320630
Working Well with Back Pain - Phase 2 RCT (active) ISRCTN41520665
Group rehabilitation + targeted work-focused intervention; Group rehabilitation
Low back pain Comp 50 Adt Sen
May-09
Oct-09 University of Nottingham, UK
http://www.controlled-trials.com/ISRCTN41520665
Exercise prescription for people with non-specific chronic low back pain RCT (active) ACTRN12608000524392
Exercise prescription informed by patient preference; Usual exercise prescription
Non-specific chronic low back pain
N/K 140 Adt Sen
Oct-08 > Oct-09
Monash University; National Health & Medical Research Council, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=83164
Efficacy of Clinical Pilates versus general exercise for chronic low back pain: a randomised controlled trial. RCT (active), Efficacy study ACTRN12609000536268
Pilates; general exercise
Chronic low back pain
N/K 86 Adt Sen
Jul-09 > Sep-09
University of Melbourne
http://www.anzctr.org.au/trial_view.aspx?ID=308126
Ultrasound Assessment During Exercise RCT (active), Efficacy Study NCT01015846
Exercise; Core stability exercise
Low Back Pain Comp 80 Adt Mar-09 Sep-09 Uni. of Virginia http://ClinicalTrials.gov/show/NCT01015846
46
Postural Re-education in Low Back Pain Phase I: Non-Randomized (active), Efficacy Study NCT00789204
Global Postural Re-education; Standard Exercise Training
Low Back Pain Comp 100 Adt Sen
May-08
Sep-09 Uni. of Bologna http://ClinicalTrials.gov/show/NCT00789204
Pilates and the effectiveness of the transversus abdominis in the individuals with low back pain Single Group Assignment ACTRN12609000927224
Pilates Low back pain Comp 20 Adt Jun-09 > Aug-09
Universidade do Estado de Santa Catarina
http://www.anzctr.org.au/trial_view.aspx?ID=320693
The effectiveness of Global Postural Reeducation Method (GPR) and conventional kinesiotherapy on pain, quality of life and functional disability in subjects with chronic spine pain. RCT (active) ACTRN12609000962235
Global Postural re-education; Kinesiology
Spine, Chronic pain; Chronic neck pain; chronic low back pain
Active NR
150 Adt Oct-07 > Aug-09
Universidade Federal de Sao Paulo
http://www.anzctr.org.au/trial_view.aspx?ID=308378
The role of attention re-training on pain tolerance in adults with acute low back pain RCT (placebo) ACTRN12608000380392
Attention retraining; placebo
Acute low back pain
N/K 128 Adt Sen
Jun-08 > Jun-09
University of Sydney
http://www.anzctr.org.au/trial_view.aspx?ID=82935
Interventional Study of Effects on Spine Height With Two Unloading Positions Single Group Assignment, Efficacy Study NCT01048749
Aquatic vertical suspension.; Land-based supine flexion
Low Back Pain Comp 60 Adt Sen
Aug-08 Jun-09 Texas Tech Uni. Health Sciences Center
http://ClinicalTrials.gov/show/NCT01048749
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain Phase II: RCT (placebo), Efficacy Study NCT00176163
Operant behavioral treatment; THC
Fibromyalgia; Back Pain
Comp 240 Adt Sen
Aug-05 May-09
Uni. of Heidelberg, Germany
http://ClinicalTrials.gov/show/NCT00176163
47
Effectiveness of Cognitive Behavioral Treatment and Mindfulness Based Stress Reduction (MBSR) for Chronic Low Back Pain Phase II: RCT (active), Efficacy Study NCT00360802
CBT; Mindfulness Based Stress Reduction
Chronic Low Back Pain
Comp 330 Adt Sen
May-06
May-09
Kovacs Foundation; Spanish Back Pain Research Network; Fondo de Investigacion Sanitaria; Universitat Autonoma de Barcelona
http://ClinicalTrials.gov/show/NCT00360802
Transmural occupational care for low back pain, a randomised controlled trial and cost-effectiveness evaluation RCT ISRCTN28478651
Graded activity protocol; workplace adaptations
Low back pain Comp 160 Adt Mar-05 Mar-09 TNO Quality of life (Work & Employment), The Netherlands
http://www.controlled-trials.com/ISRCTN28478651
Participatory ergonomics for the primary prevention of back and neck pain: a cost-effectiveness study RCT (placebo) ISRCTN27472278
Participative ergonomic program
Back pain; Neck pain; prevention
Comp 3668 Adt Sen
Oct-07 Oct-08 VU University Medical Centre, The Netherlands
http://www.controlled-trials.com/ISRCTN27472278
Anticipatory Muscle Control and Effect of Stabilizing Exercises in Patients With Subacute and Chronic Low Back Pain RCT (active), Efficacy Study NCT00201513
Exercise or information
Low Back Pain Active NR
99 Adt Jan-06 Oct-08 Norwegian Uni. of Science and Technology; Norwegian Fund for Postgraduate Training in Physiotherapy
http://ClinicalTrials.gov/show/NCT00201513
UK-Back Skills Training Trial (UK-BeST) A multi-centred randomised controlled trial of a primary-care based cognitive behavioural program (CBP) for low back pain (LBP) RCT ISRCTN54717854
Group CBT Low back pain Comp 700 Adt Sen
Oct-03 Oct-08 Department of Health, UK
http://www.controlled-trials.com/ISRCTN54717854
A Trial on the Effect on Low Back Pain Related Disability of Different Health Education Programs for Retired Persons Phase II: RCT (active), Efficacy Study NCT00441038
The Back Guide; The Back Book; Cardiovascular and general health
Low Back Pain Wtdwn 1100 Child Adt Sen
Dec-06 Sep-08 Kovacs Foundation; Conseill Insular de Ibiza y Formentera; Instituto de Asuntos Sociales y Deportes de Mallorca
http://ClinicalTrials.gov/show/NCT00441038
48
Mindfulness Meditation for Chronic Low Back Pain in Older Adults RCT (active), Efficacy Study NCT00494845
Mindfulness (MBSR); Health Education Class
Low Back Pain Active NR
40 Adt Sen
Jul-07 Sep-08 Uni. of Pittsburgh; National Center for Research Resources (NCRR)
http://ClinicalTrials.gov/show/NCT00494845
Health Education vs. Health Education Plus Physical Therapy for Low Back Pain Patients Phase II: RCT (active), Efficacy Study NCT00439764
General health talk; Handout of The Back Book; Back exercise
Low Back Pain Comp 680 Adt Sen
Mar-07 Sep-08 Kovacs Foundation; Consejería de Sanidad, Junta de Castilla y León
http://ClinicalTrials.gov/show/NCT00439764
Back School Efficacy on Low Back Pain and Quality of Life of Workers. COPCORD STUDY (Stage II) Phase III: Single Group Assignment, Efficacy Study NCT00596076
Back School Low Back Pain Comp 30 Adt Feb-08 Sep-08 Tehran Uni. of Medical Sciences
http://ClinicalTrials.gov/show/NCT00596076
Tai chi for long-term low back pain RCT (active) ACTRN12608000270314
Tai Chi; Usual care Long-term low back pain
N/K 160 Adt Sen
Jun-08 > Aug-08
University of Sydney
http://www.anzctr.org.au/trial_view.aspx?ID=82843
BackReady coaching for return to usual activity RCT (active) ACTRN12607000458437
Motor control exercise; Graded activity
Chronic low back pain
N/K 172 Adt Sen
Aug-08 > Aug-08
University of Sydney; University of Queensland
http://www.anzctr.org.au/trial_view.aspx?ID=82246
A pragmatic multicentre randomised controlled trial of yoga therapy for chronic low back pain RCT UKCRN ID 3915
Yoga Chronic low back pain
Active NR
262 Adt N/K Aug-08 University of York http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=3915
Could a Simple Information Booklet Modify Low Back Pain Patients Beliefs After Lumbar Discectomy? Phase III: RCT (active), Efficacy Study NCT00761111
Assessment of the Your Back Operation
Back Pain Active NR
140 Adt Sen
Jun-07 May-08
Uni. Hosp, Clermont-Ferrand
http://ClinicalTrials.gov/show/NCT00761111
Development of a Web-Based Interactive Patient Decision Aid for the Treatment of Acute Low Back Pain and Depression RCT (active), Efficacy Study NCT00525811
Patient dialogue; Patient information
Acute Low Back Pain; Depression
Comp 741 Adt Jun-07 May-08
Uni. Hosp Freiburg http://ClinicalTrials.gov/show/NCT00525811
49
Device
Spinal Cord Stimulation With Precision® SCS System Versus Reoperation for Failed Back Surgery Syndrome Phase IV: Randomized, Parallel Assignment, Efficacy Study NCT01036529
Precision Spinal Cord Stimulation; Procedure: Back Surgery
Failed Back Surgery Syndrome; Leg Pain; Back Pain; Spinal Cord Stimulation
Rec 132 Adt Sen
Feb-10 Aug-15 Boston Scientific Corporation
http://ClinicalTrials.gov/show/NCT01036529
Study Comparing Cortical Function and Dysfunction Tests in Low Back Pain Randomized, Parallel Assignment NCT00924495
Transcranial magnetic stimulation
Chronic Nonspecific Low Back Pain
Rec 80 Adt
M-only
Jun-09 Dec-13 Kuopio Uni. Hosp http://ClinicalTrials.gov/show/NCT00924495
Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain Phase IV: Single Group Assignment, Safety/Efficacy Study NCT01096147
Octad® lead (Spinal cord stimulation)
Failed Back Surgery Syndrome
Rec 300 Adt Sen
Feb-10 Aug-12 Medtronic Neuromodulation Europe
http://ClinicalTrials.gov/show/NCT01096147
PSU Lumbar Support for Prevention of Low Back Pain in Rubber Tapper Phase III: RCT (active), Efficacy Study NCT01017588
PSU lumbar back support
Low Back Pain Not yet Rec
200 Child Adt
Jan-10 Jun-12 Prince of Songkla Uni.
http://ClinicalTrials.gov/show/NCT01017588
Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Joint Pain Using the Sinergy System RCT (placebo), Efficacy Study NCT00802997
Sinergy; Placebo/Sham
Sacroiliac Pain Rec 51 Adt Sen
Jun-08 Dec-11 Coastal Orthopedics & Sports Medicine
http://ClinicalTrials.gov/show/NCT00802997
Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System vs. Conservative Care Phase III: RCT (active), Safety/Efficacy Study NCT00456378
DIAM™ Spinal Stabilization System; Conservative care
Lumbar Degenerative Disc Disease
Rec 306 Adt Sen
Dec-06 Nov-10 Medtronic Spinal and Biologics
http://ClinicalTrials.gov/show/NCT00456378
50
Trial on the Effect of Optically Modified Fiber Mattress Covers on Sleep Disturbances in Patients With Chronic Back Pain RCT (placebo), Safety/Efficacy Study NCT00969540
Specific mattress cover; Placebo garment mattress cover
Back Pain; Insomnia
Active NR
6 Adt Sen
Jun-09 Jun-10 Uni. of California, Irvine
http://ClinicalTrials.gov/show/NCT00969540
A study to investigate the effect of a new postural bio-feedback device on low back pain. RCT (placebo) ACTRN12609000157279
Postural bio-feedback device; Postural device with bio-feedback disabled
Low back pain Active 48 Adt May-09
> May-10
Pro-Active Medical, Melbourne
http://www.anzctr.org.au/trial_view.aspx?ID=83744
The Effectiveness of Wet Cupping on Persistent Non-specific Low Back Pain Randomized, Parallel Assignment, Safety/Efficacy Study NCT00925951
Wet Cupping; Drug: Acetaminophen
Low Back Pain Comp 37 Adt Jun-09 Dec-09 Korea Institute of Oriental Medicine
http://ClinicalTrials.gov/show/NCT00925951
Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Pain, Responders and Non-Responders? Observational: Prospective, Cohort Study NCT00885859
TENStemeco Schwa Medico (TENS)
Neck Pain; Lower Back Pain; Shoulder Pain
Not yet Rec
62 Adt Sen
Jun-09 Dec-09 Maastricht Uni. Medical Center
http://ClinicalTrials.gov/show/NCT00885859
Advanced MR Imaging in Patients With Painful, Degenerative Disc Disease: A Pilot Study Factorial Assignment NCT00706459
Magnetic Resonance Imaging
Degenerative Disc Disease
Rec 105 Adt Mar-05 Dec-09 Uni. of California, San Francisco; National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT00706459
Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain Phase II: RCT (active), Safety/Efficacy Study NCT00469118
DRX9000™ Low Back Pain Term 6 Adt Sen
Feb-09 Nov-09 NEMA Research, Inc.
http://ClinicalTrials.gov/show/NCT00469118
Orthotic Use for Chronic Low Back Pain NCT00976664
Shoe orthotic Chronic Low Back Pain
Rec N/K Adt Sen
N/K ? Sep-09
National Uni. of Health Sciences; Foot Levelers, Inc.
http://ClinicalTrials.gov/show/NCT00976664
51
A Randomized Prospective Study to Evaluate the Effectiveness of Orthopedic Spinal Supports in the Treatment of Low Back Pain Randomized, Parallel Assignment, Efficacy Study NCT00553540
Back supports Low Back Pain Active NR
50 Adt Oct-06 Aug-09 Cleveland Clinic Florida; Integral Orthopedics Inc.
http://ClinicalTrials.gov/show/NCT00553540
Effectiveness of Mechanical Decompression for Low Back Pain Relief RCT (placebo) NCT00704210
SpineMed Table, Cert HealthSciences LLC
Low Back Pain Active NR
128 Adt Sen
Aug-06 Jul-09 State Uni. of New York - Upstate Medical Uni.
http://ClinicalTrials.gov/show/NCT00704210
The Effectiveness of the Logic Back™Support. Non-Randomized, Parallel Assignment (placebo) NCT00754585
Logic Back Grahl Duo Back Model
DB11‐01
Low Back Pain; Posture
Rec 24 Adt
M-only
Aug-08 May-09
Canadian Memorial Chiropractic College; Logic Back; McMaster Uni.
http://ClinicalTrials.gov/show/NCT00754585
Non-Invasive Targeted Electronic Pain Control Device (“Biowave System”) versus Transcutaneous Electrical Nerve Stimulation (TENS) for the Symptomatic Treatment of Chronic Low Back Pain Phase III: RCT (active), Safety/Efficacy Study NCT00277797
Biowave Targeted Non-Invasive Electronic Pain Control Device; TENS device
Chronic Low Back Pain
Active NR
50 Adt Feb-01 Apr-09 Weill Medical College of Cornell Uni.; Biowave Corporation
http://ClinicalTrials.gov/show/NCT00277797
Spinal Cord Stimulation (SCS) for Neuropathic Pain of Back or Lower Extremity Phase IV: RCT (active), Efficacy Study NCT00399841
Precision for Spinal Cord Stimulation
Intractable Neuropathic Pain; Pain; Back Pain; Lower Extremity Pain
Term 13 Adt Sen
Nov-06 Feb-09 Boston Scientific Corporation
http://ClinicalTrials.gov/show/NCT00399841
E-STIM Trial: Comparing the Efficacy of the Empi Select TENS to a Control for the Treatment of Chronic Lower Back Pain RCT (placebo), Efficacy Study NCT00709748
Empi Select TENS Device; Placebo
Lower Back Pain Rec 300 Adt Feb-08 Feb-09 Empi, A DJO Company; Alquest
http://ClinicalTrials.gov/show/NCT00709748
52
Electrical Acupuncture and Laser Therapy for Low Back Pain Phase I/ II: Randomized, Parallel Assignment, Efficacy Study NCT00779818
Electrical acupuncture; Laser
Chronic Low Back Pain
Rec 40 Adt Oct-08 Jan-09 Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00779818
Restoration of Disc Height Reduces Chronic Low Back Pain Observational: Retrospective, Cohort Study NCT00828880
DRX9000; non invasive spinal decompression
Chronic Low Back Pain
Comp Adt Sen
N/K ? Jan-09
NEMA Research, Inc.; Axiom Worldwide, LLC
http://ClinicalTrials.gov/show/NCT00828880
Percutaneous Neuromodulation Therapy (PNT) With Chronic Low Back Pain Patients Phase IV: RCT (placebo), Efficacy Study NCT00290238
Vertis Percutaneous Neuromodulation Therapy (PNT); Transcutaneous Electrical Nerve Stimulation (TENS)
Low Back Pain Term 122 Adt Sen
Dec-05 Sep-08 RS Medical http://ClinicalTrials.gov/show/NCT00290238
Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation in Patients With Chronic Low Back Pain or Lumbo-Radiculalgia Phase IV: RCT (placebo), Efficacy Study NCT00452010
CEFAR PRIMO TENS Class IIA (active); CEFAR PRIMO TENS Class IIA (no active)
Chronic Low Back Pain; Chronic Lumbo-Radiculalgia
Comp 236 Adt Sen
Sep-06 Sep-08 Centre Hospier Universitaire de Saint Etienne; Ministry of Health, France
http://ClinicalTrials.gov/show/NCT00452010
Prometra's Utilization in Mitigating Pain II NCT00866164
Prometra Programmable Pump
Intractable Pain; Back Pain; Leg Pain; Arm Pain; Trunk Pain
Expand N/K Adt Sen
InSet Technologies http://ClinicalTrials.gov/show/NCT00866164
Drugs including biologics
Efficacy of Antidepressants in Chronic Back Pain Phase II: Randomized, Parallel Assignment, Efficacy Study NCT00964886
Desipramine hydrochloride; Desipramine hydrochloride + CBT; CBT; Benztropine mesylate + CBT; Placebo
Back Pain Not yet Rec
200 Adt Sen
Jan-10 Dec-14 Department of Veterans Affairs; Uni. of California, San Diego
http://ClinicalTrials.gov/show/NCT00964886
53
The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery Phase III: RCT (placebo), Efficacy Study NCT01073995
Kenalog; Sensorcaine
Radiculopathy Rec 100 Adt Mar-10 Mar-14 Saint John Regional Hosp
http://ClinicalTrials.gov/show/NCT01073995
Evaluation of the Effectiveness of Transforaminal Epidural Injections in Lumbar Disc Herniation or Radiculitis RCT (active), Safety/Efficacy Study NCT01052571
Lumbar transforaminal epidural injections
Low Back Pain Not yet Rec
120 Adt Sen
Feb-10 Jan-14 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01052571
Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients RCT (active), Safety/Efficacy Study NCT01053572
Celestone; Substitute Celestone; Substitute Hypertonic Sodium Chloride; Substitute hypertonic sodium chloride and Celestone
Low Back Pain Invite 240 Adt Sen
Feb-10 Jan-14 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01053572
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain Phase II: Parallel Assignment, Safety/Efficacy Study NCT00973024
JNJ-42160443; Placebo
Low Back Pain; Low Back Pain, Recurrent
Active NR
360 Adt Sen
N/K Dec-12 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
http://ClinicalTrials.gov/show/NCT00973024
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Phase III: RCT (placebo), Safety/Efficacy Study NCT01011816
Biostat System; Sodium Chloride Injection
Back Pain; Chronic Low Back Pain; Internal Disc Disruption; Degenerative Disc Disease
Rec 260 Adt Sen
Mar-10 Aug-12 Spinal Restoration, Inc.
http://ClinicalTrials.gov/show/NCT01011816
Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Phase IV: RCT (dose comparison), Safety/Efficacy Study NCT00715091
Diclophenac Ankylosing Spondylitis
Not yet Rec
360 Adt Jul-08 Jul-12 Charite Uni., Berlin, Germany
http://ClinicalTrials.gov/show/NCT00715091
54
Intra-Discal Steroid Injection for MODIC I Discopathy Phase IV: RCT (placebo), Safety/Efficacy Study NCT00804531
Visipaque - Hydrocortancyl; Placebo
Chronic Low Back Pain
Active NR
134 Adt Oct-08 Jan-12 Assistance Publique - Hôpitaux de Paris
http://ClinicalTrials.gov/show/NCT00804531
A Study of the Safety and Efficacy of Golimumab in Subjects With Active Ankylosing Spondylitis Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00265083
Golimumab; Placebo
Spondylitis, Ankylosing
Active NR
356 Adt Sen
Nov-05 Jan-12 Centocor, Inc.; Schering-Plough
http://ClinicalTrials.gov/show/NCT00265083
The Effect of PTH(1-84) or Alendronate on Reduction of Back Pain in Postmenopausal Women With an Osteoporosis Related Vertebral Fracture(s) (FP-005-IM) Phase IV: RCT (active), Safety/Efficacy Study NCT00713258
Parathyroid hormone (PTH) (1-84); Alendronate
Back Pain Active NR
300 Adt Sen
F-
only
Apr-08 Dec-11 Nycomed http://ClinicalTrials.gov/show/NCT00713258
Long Term Safety Study of Tanezumab in Chronic Low Back Pain Phase II/III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00924664
Tanezumab 20 mg; Tanezumab 10 mg
Low Back Pain Rec 1040 Adt Sen
Aug-09 Nov-11 Pfizer http://ClinicalTrials.gov/show/NCT00924664
Pilot Study to Assess the Efficacy of Botulinum Toxin A Treatments on Pain and Disability in Sub-Acute Low Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00384371
Botulinum Toxin A; Placebo
Low Back Pain Term 0 Adt Jun-08 Sep-11 Department of Defense
http://ClinicalTrials.gov/show/NCT00384371
Phase 3 Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Low Back Pain Phase III: RCT (active), Safety/Efficacy Study NCT01081912
Hydrocodone bitartrate; Placebo
Chronic Low Back Pain
Rec 340 Adt Sen
Mar-10 Jun-11 Zogenix, Inc. http://ClinicalTrials.gov/show/NCT01081912
55
Treatment of Notalgia Paresthetica With Xeomin Phase III: Randomized, Crossover Assignment, Safety/Efficacy Study NCT01098019
Xeomin; Placebo Notalgia Paresthetica
Rec 20 Adt Sen
Apr-10 May-11
Innovaderm Research Inc.; Merz Pharmaceuticals GmbH
http://ClinicalTrials.gov/show/NCT01098019
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica Phase II: RCT (placebo), Efficacy Study NCT00668434
Prednisone; Placebo
Sciatica Rec 270 Adt Nov-08 May-11
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00668434
Analgesic Efficacy of Intravenous Lidocaine for Postoperative Pain Following Adult Spine Surgery RCT (dose comparison), Efficacy Study NCT01043211
Lidocaine Hydrochoride Injection, without epinephrine; Normal Saline
Back Pain Not yet Rec
100 Adt Sen
Apr-10 Apr-11 Uni. of Alabama at Birmingham
http://ClinicalTrials.gov/show/NCT01043211
Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Subjects Phase I: Randomized, Parallel Assignment, Pharmacokinetics Study NCT00961766
BG00010; Placebo Sciatica Rec 56 Adt Sen
Aug-09 Apr-11 Biogen Idec http://ClinicalTrials.gov/show/NCT00961766
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug (NSAID) Treatment Phase III: Single Group Assignment, Safety Study NCT00984815
HZT-501 OA; RA; Chronic Low Back Pain; Chronic Regional Pain Syndrome; Chronic Soft Tissue Pain
Rec 100 Adt Sen
Sep-09 Mar-11 Horizon Therapeutics, Inc.
http://ClinicalTrials.gov/show/NCT00984815
A Study for Teriparatide in Severe Osteoporosis Observational: Prospective, Cohort Study NCT00696644
Teriparatide Osteoporosis, Post-menopausal; Osteoporosis
Active NR
650 Adt Sen
Jun-08 Feb-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00696644
56
Study of FORTEO Use in Subjects in the Community Setting Observational: Prospective, Cohort Study NCT01078805
FORTEO Osteoporosis Active NR
4126 Child Adt Sen
Aug-03 Feb-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT01078805
Efficacy and Safety of EN3324 in Subjects With Chronic Low Back Pain Phase II: Randomized, Parallel Assignment, Efficacy Study NCT01043263
EN3324; Placebo Chronic Low Back Pain
Rec 240 Adt Sen
Dec-09 Feb-11 Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT01043263
Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00404417
Botulinum Toxin A; Placebo
Chronic Low Back Pain
Active NR
160 Adt Sen
Mar-07 Feb-11 Walter Reed Army Medical Center
http://ClinicalTrials.gov/show/NCT00404417
Vitamin D Treatment to Patients Suffering From Chronic Pain and Vitamin D Hypovitaminosis RCT (placebo), Safety/Efficacy Study NCT01023490
Vitamin D; Placebo Back Pain; Hypo-vitaminosis D
Not yet Rec
40 Adt Sen
Jan-10 Jan-11 Tel-Aviv Sourasky Medical Center
http://ClinicalTrials.gov/show/NCT01023490
Back Pain in Patients With Severe Osteoporosis Observational: Prospective, Cohort Study NCT00761332
Teriparatide; Antiresorptives
Osteoporosis Active NR
600 Adt Sen
Feb-08 Jan-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00761332
Single Injection of REGN475/SAR164877 in Treatment of Vertebral Fracture Pain Phase II: Randomized, Parallel Assignment, Efficacy Study NCT01001715
REGN475/SAR164877; Placebo
Back Pain Rec 100 Adt Sen
Nov-09 Jan-11 Sanofi-Aventis; Regeneron Pharmaceuticals
http://ClinicalTrials.gov/show/NCT01001715
Study of the Efficacy and Safety of Bupivacaine TTS Patch in Patients With Chronic Low Back Pain Phase II: RCT (placebo), Efficacy Study NCT01096966
Bupivacaine TTS (Bupivacaine Patch); Placebo
Chronic Low Back Pain
Rec 260 Adt Sen
Mar-10 Jan-11 King Pharmaceuticals Research and Development; Durect Corporation
http://ClinicalTrials.gov/show/NCT01096966
57
Lumbar Stenosis Outcomes Research II Phase IV: Randomized, Crossover Assignment NCT00652093
Propoxyphene/ acetaminophen; Oxymorphone hydrochloride; Placebo
Neurogenic Intermittent Claudication
Rec 48 Adt Sen
Mar-08 Dec-10 Uni. of Rochester; Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00652093
Combination Disease-Modifying Antirheumatic Drugs (DMARDs) Versus Sulfasalazine in Inflammatory Back Pain Phase III: RCT (placebo), Efficacy Study NCT01040195
Methotrexate, Hydroxy-chloroquine; Placebo
Seronegative Spondylo-arthropathies
Rec 100 Adt Jun-09 Dec-10 Sanjay Gandhi Postgraduate Institute of Medical Sciences
http://ClinicalTrials.gov/show/NCT01040195
A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Phase II/ III: RCT (placebo), Efficacy Study NCT00733096
Etanercept; Methyl-prednisolone; Normal saline
Lumbosacral Radiculopathy
Rec 78 Adt Sen
Aug-08 Dec-10 Johns Hopkins Uni.; Walter Reed Army Medical Center; National Naval Medical Center; Womack Army Medical Center; Landstuhl Regional Medical Center; Massachusetts General Hosp
http://ClinicalTrials.gov/show/NCT00733096
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis Phase IV: RCT (active), Safety/Efficacy Study NCT00784810
Oxycodone/ Naloxone
OA; Back Pain Active NR
244 Adt Sen
Jan-09 Nov-10 Napp Pharmaceuticals Limited
http://ClinicalTrials.gov/show/NCT00784810
Cipralex in Treatment of Depressive Symptoms and Chronic Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00227292
Escitalopram; Placebo
Low Back Pain; Depression
Rec 106 Adt Nov-07 Nov-10 Martin-Luther-Universität Halle-Wittenberg
http://ClinicalTrials.gov/show/NCT00227292
58
Efficacy of AIN457 in Adults (18-65 Years) With Moderate to Severe Ankylosing Spondylitis Phase I/II: RCT (active), Efficacy Study NCT00809159
AIN457; Placebo Ankylosing Spondylitis
Rec 30 Adt Mar-09 Nov-10 Novartis http://ClinicalTrials.gov/show/NCT00809159
NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain Phase III: Randomized, Parallel Assignment, Efficacy Study NCT00986180
NUCYNTA; Oxycodone IR
Pain; Back Pain; Low Back Pain; Back Pain With Radiation
Rec 652 Adt Sen
Sep-09 Oct-10 Ortho-McNeil Janssen Scientific Affairs, LLC; GrÜnenthal
http://ClinicalTrials.gov/show/NCT00986180
Epidural Study of Patients With Chronic Lower Back Pain RCT (dose comparison), Efficacy Study NCT00887003
Bupivacaine; Depo-Medrol
Chronic Low Back Pain
Rec 280 Adt Sen
May-05
Sep-10 Hamilton Health Sciences
http://ClinicalTrials.gov/show/NCT00887003
Double-blind, randomised, placebo-controlled prospective multicenter phase III trial to assess the efficacy and safety of topical propyl nicotinate (Elacur® hot) in adjuvant treatment of chronic non-specific low back pain Phase III: RCT (placebo) DRKS00000183
Propyl nicotinate cream; Placebo cream
Chronic non-specific low back pain
N/K 460 Adt Sen
Aug-10 > Aug-10
Riemser Arzneimittel AG, Germany
http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000183
Pilot Study to Assess the Efficacy of Botulinum Toxin B on Pain and Disability in Subjects With Acute Low Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00384579
Botulinum toxin B; Placebo
Low Back Pain Term 0 Adt Feb-08 Aug-10 Department of Defense
http://ClinicalTrials.gov/show/NCT00384579
SI-6603 Versus Placebo in Patients With Lumbar Disc Herniation Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00634946
SI-6603; Placebo Lumbar Vertebra Hernia
Active, not Rec
195 Adt Sen
Jan-08 Aug-10 Seikagaku Corporation
http://ClinicalTrials.gov/show/NCT00634946
59
Efficacy of Pregabalin in Patients With Radicular Pain Phase IV: RCT (placebo), Efficacy Study NCT00908375
Pregabalin; Sugar Pill
Lumbar Radicular Pain; Failed Back Surgery Syndrome; Spinal Stenosis; Herniated Disc
Rec 38 Adt May-09
Jul-10 Northwestern Uni. http://ClinicalTrials.gov/show/NCT00908375
Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Randomized, Parallel Assignment NCT00619983
Donepezil; Duloxetine; Donepezil & Duloxetine; Gabapentin; Placebo
Diabetic Neuropathic Pain; Chronic Low Back Pain
Rec 60 Adt Sen
Feb-08 Jul-10 Wake Forest Uni.; National Institute of Neurological Disorders and Stroke (NINDS)
http://ClinicalTrials.gov/show/NCT00619983
A Study of Tanezumab in Adults With Chronic Low Back Pain Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00876187
Tanezumab 20mg, 10mg & 5mg IV; Naproxen; Placebos
Low Back Pain Rec 1300 Adt Sen
Jun-09 Jul-10 Pfizer http://ClinicalTrials.gov/show/NCT00876187
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability Phase III: Single Group Assignment, Safety/Efficacy Study NCT00986258
Tapentadol Chronic Pain Due to Low Back Pain
Rec 180 Adt Sen
Sep-09 Jun-10 GrÜnenthal GmbH http://ClinicalTrials.gov/show/NCT00986258
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics Phase III: Single Group Assignment, Safety/Efficacy Study NCT00983385
Tapentadol Chronic Pain; Low Back Pain
Rec 180 Adt Sen
Sep-09 Jun-10 GrÜnenthal GmbH http://ClinicalTrials.gov/show/NCT00983385
60
Efficacy and Safety of Ralfinamide in Patients With Chronic Neuropathic Low Back Pain Phase III: RCT (placebo), Safety/Efficacy Study NCT01019824
Ralfinamide Pain Active NR
400 Adt Sen
Jan-09 Jun-10 Newron Pharmaceuticals S.p.A.; Parexel; CliniRx
http://ClinicalTrials.gov/show/NCT01019824
A Pilot Trial of Intravenous (IV) Pamidronate for Low Back Pain Phase I: Single Group Assignment, Randomized Study NCT00101790
Pamidronate Low Back Pain Active NR
44 Adt Sen
Sep-03 Jun-10 Mount Sinai School of Medicine; National Institute of Neurological Disorders and Stroke (NINDS)
http://ClinicalTrials.gov/show/NCT00101790
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication Randomized, Crossover Assignment NCT00388414
Duloxetine Low Back Pain Active NR
75 Adt Sep-06 Jun-10 Stanford Uni. http://ClinicalTrials.gov/show/NCT00388414
A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain Phase II: RCT (placebo), Safety/Efficacy Study NCT00991172
REGN475; REGN475; Placebo Injection
Sciatica Active NR
150 Adt Nov-09 May-10
Regeneron Pharmaceuticals; Sanofi-Aventis
http://ClinicalTrials.gov/show/NCT00991172
Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected Phase I: Non-Randomized, Parallel Assignment, Efficacy Study NCT01030640
Tanezumab; Placebo
OA Pain; Chronic Low Back Pain; Pain Due to Interstitial Cystitis
Active NR
28 Adt Jan-10 Apr-10 Pfizer http://ClinicalTrials.gov/show/NCT01030640
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults Phase IV: RCT (active), Efficacy Study NCT00696293
Duloxetine + Clinical Management; Duloxetine + Problem Solving Therapy for Depression and Pain (PST-DP).
Major Depressive Disorder; Back Pain; Aged
Comp 80 Adt Sen
May-07
Apr-10 Uni. of Pittsburgh; National Institutes of Health (NIH); Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00696293
61
Study to Assess the Effectiveness and Safety of FLECTOR® Patch for Treatment of Acute Back Strain Phase IV: Single Group Assignment, Efficacy Study NCT01054820
FLECTOR® Patch (diclofenac epolamine topical patch) 1.3%
Acute Back Strain
Comp 123 Adt Sen
Jan-10 Mar-10 Alpharma Pharmaceuticals LLC, a subsidiary of King Pharmaceuticals, Inc.
http://ClinicalTrials.gov/show/NCT01054820
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain RCT (dose comparison), Safety/Efficacy Study NCT00370799
Caudal epidural injection; Caudal Epidural Injection with generic Celestone; Caudal Epidural Injection with Celestone; Caudal Epidural Injection with DepoMedrol
Low Back Pain Active NR
240 Adt Sen
Jan-06 Mar-10 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT00370799
Post-operative Epidural Analgesia After Minimally Invasive Lumbar Decompression and Fusion RCT (placebo) NCT00644111
Bupivicaine, Hydromorphone; Saline Placebo
Low Back Pain Rec 32 Adt Sen
Feb-08 Mar-10 Uni. Health Network, Toronto
http://ClinicalTrials.gov/show/NCT00644111
Paracetamol for low back pain RCT (placebo), Efficacy Study ACTRN12609000966291
Paracetamol, time contingent; PRN Paracetamol; Placebo
Low back pain N/K 1650 Child Adt Sen
Nov-09 > Feb-10
The George Institute of International Health
http://www.anzctr.org.au/trial_view.aspx?ID=320742
A Confirmatory Study of JNS020QD (Fentanyl) in Patients With Osteoarthritis or Low Back Pain Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT01008618
Fentanyl; JNS020 Pain Comp 151 Adt Sen
Sep-08 Feb-10 Janssen Pharmaceutical K.K.
http://ClinicalTrials.gov/show/NCT01008618
62
Double-blind, randomised, multi-centre, placebo-controlled clinical trial to investigate the efficacy and safety of a combination of comfrey root extract plus methyl nicotinate versus a preparation containing methyl nicotinate alone or placebo in patients with conditions of acute upper or low back pain Phase III: RCT (placebo) DRKS00000326
Comfrey root extract + methyl nicotinate; methyl nicotinate
Low back pain; pain in thoracic spine
N/K 390 Adt Nov-09 > Jan-10
Merck Selbst-medikation GmbH
http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000326
Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00771758
Oxycodone IR; Tapentadol IR; placebo
Back Pain Comp 108 Adt Sen
Aug-08 Dec-09 Ortho-McNeil Janssen Scientific Affairs, LLC; GrÜnenthal GmbH
http://ClinicalTrials.gov/show/NCT00771758
D-cycloserine in the Management of Chronic Low Back Pain Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00125528
D-cycloserine; placebo
Low Back Pain; Pain
Not yet Rec
39 Adt Sen
N/K ? Dec-09
Northwestern Uni.; Rehabilitation Institute of Chicago
http://ClinicalTrials.gov/show/NCT00125528
Efficacy and Safety of Extended Release Tramadol HCl/Acetaminophen for the Treatment of Chronic Low-back Pain Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT01112267
Tramadol HCl/ acetaminophen Extended Release; Placebo
Low Back Pain Comp 222 Adt Sen
May-09
Oct-09 Janssen Korea, Ltd., Korea
http://ClinicalTrials.gov/show/NCT01112267
Phase 3 Clinical Trial of Teriparatide in Japan Phase III: RCT (placebo), Safety/Efficacy Study NCT00433160
Teriparatide; Placebo
Osteoporosis Comp 207 Adt Sen
Jan-07 Sep-09 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00433160
Chronic Low Back Pain Research Project Phase II: RCT (placebo), Efficacy Study NCT00108550
Gabapentin; Placebo
Chronic Low Back Pain
Comp 115 Adt Sen
Oct-04 Sep-09 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00108550
63
Study of the Insomnia in Patients With Low Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00365976
Eszopiclone; Placebo
Primary Insomnia
Rec 140 Adt Aug-06 Sep-09 Duke Uni.; Sepracor, Inc.
http://ClinicalTrials.gov/show/NCT00365976
Antibiotic Treatment to Patients With Low Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00302796
Bioclavid Back Pain Rec 162 Adt Mar-06 Sep-09 The Back Research Center, Denmark
http://ClinicalTrials.gov/show/NCT00302796
Treatment With ARRY-371797 in Patients With Active Ankylosing Spondylitis Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00811499
ARRY-371797; Placebo
Ankylosing Spondylitis
Comp 25 Adt Sen
Dec-08 Sep-09 Array BioPharma http://ClinicalTrials.gov/show/NCT00811499
Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip, Knee and/or Lumbar Spine Phase IV: RCT (active), Safety/Efficacy Study NCT00426647
Buprenorphine; Tramadol
OA; Pain, Lumbar spine, hip or knee
Comp 120 Adt Sen
Feb-07 Aug-09 Norpharma A/S; Mundipharma Finland
http://ClinicalTrials.gov/show/NCT00426647
Opiate-Induced Tolerance & Hyperalgesia in Pain Patients Phase IV: Randomized, Parallel Assignment NCT00246532
Morphine; Placebo Chronic Low Back Pain; Opioid-induced Hyperalgesia
Comp 160 Adt Sen
Oct-05 Aug-09 National Institute of General Medical Sciences (NIGMS)
http://ClinicalTrials.gov/show/NCT00246532
The Glucosamine-Study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain Phase IV: RCT (placebo), Efficacy Study NCT00404079
Glucosamine sulphate; Placebo
Low Back Pain Active NR
250 Adt Sen
Dec-06 Aug-09 Ullevaal Uni. Hosp; Stiftelsen Helse og Rehabilitering
http://ClinicalTrials.gov/show/NCT00404079
Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Phase IV: RCT (placebo), Safety/Efficacy Study NCT00647517
Ultracet Ankylosing Spondylitis
Comp 60 Adt Mar-08 Jul-09 Chung Shan Medical Uni.
http://ClinicalTrials.gov/show/NCT00647517
64
A Study for Patient With Chronic Low Back Pain Phase III: RCT (placebo), Safety/Efficacy Study NCT00767806
Duloxetine; Placebo Chronic Low Back Pain
Comp 395 Adt Sen
Sep-08 Jul-09 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00767806
A Study to Evaluate the Safety and Tolerability of Arbaclofen Placarbil (XP19986) in Subjects With Acute Back Spasms Phase II: Randomized, Parallel Assignment NCT00817986
Arbaclofen Placarbil Back Spasms Comp 161 Adt Dec-08 Jul-09 XenoPort, Inc. http://ClinicalTrials.gov/show/NCT00817986
Efficacy Safety of a Combination Thiocolchicoside+Ketoprofen Compared to Thiocolchicoside Twice a Day for 7 Days in Patients Suffering From Acute Non Specific Low Back Pain Phase III: RCT (active), Safety/Efficacy Study NCT00679146
Thiocolchicoside+ Ketoprofen; Thiocolchicoside
Low Back Pain Comp 322 Adt Apr-08 Jun-09 Sanofi-Aventis http://ClinicalTrials.gov/show/NCT00679146
An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain Phase III: Single Group Assignment, Safety/Efficacy Study NCT00487435
CG5503 Pain; OA; Low Back Pain
Comp 1166 Adt Sen
Feb-07 Jun-09 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00487435
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP). Phase III: Randomized, Parallel Assignment NCT00763321
ABT-712; Placebo Chronic Low Back Pain
Comp 223 Adt Sen
Aug-08 Apr-09 Abbott http://ClinicalTrials.gov/show/NCT00763321
65
Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back Phase III: RCT (placebo), Safety/Efficacy Study NCT00671879
Carisoprodol SR 700 mg; Carisoprodol SR 500 mg; Placebo
Lower Back Pain Comp 840 Adt Sen
Apr-08 Mar-09 Meda Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00671879
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP). Phase III: Randomized, Parallel Assignment NCT00761150
ABT-712; Placebo Chronic Low Back Pain
Comp 200 Adt Sen
Aug-08 Mar-09 Abbott http://ClinicalTrials.gov/show/NCT00761150
A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Acetaminophen and Tramadol Combination BID Versus Placebo for the Treatment of Acute Low Back Pain Phase III: Parallel Assignment NCT00643383
Combination drug (Acetaminophen + Tramadol); Placebo
Acute Low Back Pain
Comp 250 Adt Sen
Mar-08 Feb-09 Labopharm Inc. http://ClinicalTrials.gov/show/NCT00643383
Epidural Clonidine for Lumbosacral Radiculopathy RCT (active), Efficacy Study NCT00588354
Clonidine; Triamcinolone
Acute Lumbosacral Radiculopathy Due to Herniated Disk
Active NR
40 Adt Sen
Oct-06 Feb-09 Mayo Clinic http://ClinicalTrials.gov/show/NCT00588354
A Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back Phase III: RCT (active), Safety/Efficacy Study NCT00671502
Carisoprodol; Carisoprodol SR; Placebo
Lower Back Pain Comp 840 Adt Sen
Apr-08 Feb-09 Meda Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00671502
66
Study to Test the Effectiveness of Controlled-Release OROS® Hydromorphone HCl Compared to Placebo in Patients With Chronic Low Back Pain Phase III: RCT (placebo), Efficacy Study NCT00549042
OROS® hydromorphone at 4, 8, 16, and 32 mg tablets used to provide doses of 12-64mg.
Chronic Low Back Pain
Comp 450 Adt Sen
Sep-07 Jan-09 Neuromed Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00549042
Efficacy of Disci/Rhus Toxicodendron Comp.®, in Patients With Chronic Low Back Pain Phase III: RCT (placebo), Efficacy Study NCT00567736
Disci/Rhus toxicodendron comp.®; placebo solution
Chronic Low Back Pain
Comp 150 Adt Sen
Aug-07 Jan-09 Charite Uni., Berlin, Germany; WALA Heilmittel GmbH
http://ClinicalTrials.gov/show/NCT00567736
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940 Phase I: Randomized, Parallel Assignment, Safety Study NCT00689780
AZD1940; Midazolam
Low Back Pain Comp 60 Adt Mar-08 Jan-09 AstraZeneca http://ClinicalTrials.gov/show/NCT00689780
Neuraxial Pethidine After Lumbar Surgery Trial Phase III: RCT (placebo), Safety/Efficacy Study NCT00163553
Pethidine; Placebo Sciatica Rec 60 Adt Sen
Dec-04 ? Jan-09
Austin Health http://ClinicalTrials.gov/show/NCT00163553
Study on Impact of Fentanyl Matrix on Improvement of Pain and Functioning in Spinal Disorder-related Pain Observational: Prospective, Cohort Study NCT00797017
Fentanyl Low Back Pain Comp 1576 Adt Sen
May-08
Dec-08 Janssen Korea, Ltd., Korea
http://ClinicalTrials.gov/show/NCT00797017
A Study to Evaluate the Effectiveness and Safety of CG5503 Extended Release (ER) in Patients With Moderate to Severe Chronic Low Back Pain Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00449176
CG5503; Oxycodone; placebo
Low Back Pain Comp 977 Adt Sen
Feb-07 Dec-08 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00449176
67
Epidural Sacral Injection study: effect of volume and triamcinolone on chronic lumbosacral radiculopathy? RCT (placebo) ISRCTN12574253
Triamcinolone; Saline
Sciatica; Lumbosacral radiculopathy
Comp 240 Adt May-05
Dec-08 University Hospital of North Norway
http://www.controlled-trials.com/ISRCTN12574253
Lumbar Spinal Fibrosis and TNF Alpha Inhibition Phase III: RCT (placebo), Efficacy Study NCT00385086
TNF blocker Post Operative Sciatica by Lumbar Spinal Fibrosis
Rec 40 Adt Sen
Feb-07 Nov-08 Assistance Publique - Hopitaux de Paris
http://ClinicalTrials.gov/show/NCT00385086
Double-Blind Follow-on Safety Study of HZT-501 in Subjects Who Have Completed Participation in HZ-CA-301 or HZ-CA-303 Phase III: RCT (active), Safety Study NCT00613106
Ibuprofen/ famotidine; Ibuprofen
OA; RA; Chronic Low Back Pain; Chronic Regional Pain Syndrome; Chronic Soft Tissue Pain
Comp 300 Adt Sen
Sep-07 Oct-08 Horizon Therapeutics, Inc.
http://ClinicalTrials.gov/show/NCT00613106
Duloxetine Versus Placebo in Chronic Low Back Pain Phase III: RCT (placebo), Safety/Efficacy Study NCT00424593
Duloxetine; Placebo Back Pain Without Radiation
Comp 236 Adt Sen
Jan-07 Oct-08 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00424593
Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain Phase III: RCT (placebo), Efficacy Study NCT00490919
Buprenorphine transdermal delivery systems; Placebo
Low Back Pain Comp 520 Adt Sen
Jun-07 Oct-08 Purdue Pharma LP http://ClinicalTrials.gov/show/NCT00490919
A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain Phase III: Randomized, Parallel Assignment, Efficacy Study NCT00662558
Celecoxib; Tramadol HCL
Low Back Pain Comp 802 Adt Sen
Jan-08 Sep-08 Pfizer http://ClinicalTrials.gov/show/NCT00662558
RN624 In Adult Patients With Chronic Low Back Pain Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00584870
PF-04383119 (RN624); Naproxen; Placebo
Low Back Pain Comp 225 Adt Sen
Jul-07 Sep-08 Pfizer http://ClinicalTrials.gov/show/NCT00584870
68
Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial Phase III: RCT (placebo), Efficacy Study NCT00327730
Eperisone Muscle Spasm; Back Pain
Comp 240 Adt Oct-06 ? Sep-08
Eisai Inc.; Eisai Limited
http://ClinicalTrials.gov/show/NCT00327730
SLURP: Steroid injections in LUmbosacral Radicular Syndrome RCT (active) ISRCTN54386944
Epidural corticosteroid injection (80mg Kenacort); usual care
Lumbosacral Radicular Syndrome
Comp 80 Adt Sep-05 Sep-08 University Medical Centre Groningen, The Netherlands
http://www.controlled-trials.com/ISRCTN54386944/
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Phase III: Randomized, Parallel Assignment, Safety Study NCT00361504
Tapentadol (CG5503) PR; Oxycodone CR
OA, Hip; OA, Knee; Lower Back Pain; Pain
Comp 1122 Adt Sen
Oct-06 Jul-08 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00361504
Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan Phase III: Single Group Assignment, Safety/Efficacy Study NCT00212628
Minodronic acid hydrate
Involutional Osteoporosis
Comp 444 Adt Sen
F-
only
Jun-04 ? Jul-08
Ono Pharma; Astellas Pharma Inc
http://ClinicalTrials.gov/show/NCT00212628
Flurbiprofen Tape for Treatment of Chronic Low Back Pain Phase II: RCT (placebo), Safety/Efficacy Study NCT00759330
Flurbiprofen Tape; Placebo Tape
Chronic Low Back Pain
Comp 120 Adt Sen
Oct-07 Jul-08 Teikoku Pharma USA
http://ClinicalTrials.gov/show/NCT00759330
Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica RCT (placebo), Safety/Efficacy Study NCT00516009
Dexamethasone; Placebo
RADICULAR PAIN
Rec 40 Adt Sen
Aug-07 Jul-08 Ziv Hosp http://ClinicalTrials.gov/show/NCT00516009
69
Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Phase IV: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00873730
Etanercept; Placebo
Ankylosing Spondylitis
Comp 108 Adt Sen
Dec-06 Jun-08 Wyeth http://ClinicalTrials.gov/show/NCT00873730
Adalimumab in Severe and Acute Sciatica Phase II: RCT (placebo), Safety/Efficacy Study NCT00470509
Adalimumab (2 subcutaneous 40 mg injections on day 0 and 7)
Sciatica Comp 61 Adt Sen
May-05
Jun-08 Uni. Hosp, Geneva http://ClinicalTrials.gov/show/NCT00470509
A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Prospective Study NCT00642837
Tramadol/ acetaminophen
Rheumatic Diseases: including Low back pain
Comp 982 Child Adt Sen
Sep-07 May-08
Janssen Korea, Ltd., Korea
http://ClinicalTrials.gov/show/NCT00642837
Study on the Safety and Effectiveness of Switching Between Two Forms of Tapentadol in Patients With Chronic Low Back Pain Phase III: Randomized, Crossover Assignment, Safety/Efficacy Study NCT00594516
CG5503 IR / CG5503 ER; CG5503 ER / CG5503 IR
Low Back Pain Comp 120 Adt Sen
Nov-07 May-08
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00594516
Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain. Phase IV: RCT (active), Efficacy Study NCT00290901
Tramadol Hydrochloride 50mg; Celebrex 200mg
Back Pain Comp 754 Adt Sen
Mar-06 Dec-06 Pfizer http://ClinicalTrials.gov/show/NCT00290901
Safety and Efficacy of Adalimumab in Patients With Active Ankylosing Spondylitis Phase III: RCT (placebo), Safety/Efficacy Study NCT00195819
Adalimumab (D2E7); Placebo
Ankylosing Spondylitis
Comp 82 Adt Sen
Dec-03 Oct-04 Abbott http://ClinicalTrials.gov/show/NCT00195819
70
Other including CAM therapies
Chiropractic and Exercise Management of Spinal Dysfunction in Seniors Phase II/III: RCT (active) NCT01057706
Chiropractic; Behavioral: exercise
Neck Disability; Back Disability
Rec 300 Adt Sen
Jan-10 Aug-15 Northwestern Health Sciences Uni.; Health Resources and Services Administration
http://ClinicalTrials.gov/show/NCT01057706
PRF Treatment for Patients With Chronic Lumbosacral Radicular Pain Compared to Conventional Medical Management RCT (historical), Efficacy Study NCT00991237
Pulsed Radiofrequency
Lumbosacral Radicular Syndrome
Not yet Rec
29 Adt Sen
Feb-10 Mar-14 Maastricht Uni. Medical Center; ZOL Hosp Genk Belgium; Sint Jozef Hosp Bornem en Willebroek Belgium
http://ClinicalTrials.gov/show/NCT00991237
A Randomized, Equivalence Trial of Percutaneous Lumbar Adhesiolysis and Caudal Epidural Steroid Injections RCT (active), Safety/Efficacy Study NCT01053273
Caudal Epidural Injection; Percutaneous adhesiolysis
Low Back Pain Invite 120 Adt Sen
Feb-10 Jan-14 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01053273
Chiropractic and Exercise for Low Back Pain in Adolescents Phase II/III RCT (active), Efficacy Study NCT01096628
Chiropractic + Exercise
Low Back Pain Rec 184 Child Adt
Mar-10 Mar-13 Northwestern Health Sciences Uni.; Uni. of Western States
http://ClinicalTrials.gov/show/NCT01096628
The effect of various combinations of naprapathic manual therapy for patients with neck pain and/or back pain RCT (active) ISRCTN92249294
Naprapathic manual therapy; Naprapathic manual therapy excluding spinal manipulation; Naprapathic manual therapy except stretching
Non-specific back pain; Non-specific neck pain
Active 1050 Adt Mar-10 Dec-12 The Scandinavian College of Naprapathic Manual Medicine
http://www.controlled-trials.com/ISRCTN92249294
Efficacy of orthomanual treatment in addition to usual care in patients with chronic low back pain in an academic pain clinic population. RCT (active) NTR1818
Orthomanual treatment + usual care; usual care
Non-specific low back pain, Chronic
Active 100 Adt Sen?
Aug-09 Aug-12 EMGO Institute, The Netherlands
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1818
71
Radiofrequency Nerve Ablation Versus Sham to Treat Chronic Low Back Pain Caused by Sacroiliac Joint Dysfunction Observational: Prospective, Case-Crossover NCT01104051
Radiofrequency nerve ablation; sham
Sacroiliac Joint Dysfunction
Rec 39 Adt Sen
Apr-10 Apr-12 Coastal Orthopedics & Sports Medicine
http://ClinicalTrials.gov/show/NCT01104051
Treatment of Chronic Thoracic and Neck and Upper Extremity Pain RCT (dose comparison), Safety/Efficacy Study NCT01071369
Thoracic and cervical interlaminar epidural injections; Drug: Xylocaine; Celestone
Back Pain; Neck Pain
Active NR
240 Adt Sen
Feb-08 Feb-12 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01071369
Treatment of Chronic Low Back and Lower Extremity Pain Randomized, Parallel Assignment, Safety/Efficacy Study NCT00681447
Lumbar Interlaminar Epidural
Low Back Pain Invite 180 Adt Sen
Feb-08 Feb-12 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT00681447
The effect of shared decision-making on the recovery of non-chronic low back pain in primary care. RCT (active) NTR1960
Shared decision making (patients & GP); Usual care
Non-chronic low back pain
Active 600 Adt Mar-10 Jan-12 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1960
Effectiveness of a multidisciplinary intervention in subacute low back pain in the working population RCT ISRCTN21392091
Multidisciplinary intervention; Standard clinical practice
Sub-acute low back pain
Active 932 Adt Jan-09 Dec-11 La Marató de TV3 Foundation, Spain
http://www.controlled-trials.com/ISRCTN21392091
A Random Controlled Test (RCT): Acupuncture Treatment on Nonspecific Low Back Pain (NLBP) RCT (placebo), Efficacy Study NCT01049074
Acupuncture Treatment; Sham acupuncture
Low Back Pain Rec 534 Adt Sen
Nov-08 Nov-11 Beijing Hosp of Traditional Chinese Medicine
http://ClinicalTrials.gov/show/NCT01049074
Assess the Effectiveness of Pulse RadioFrequency in Patients With Chronic Lumbar Radicular Pain RCT (placebo), Safety/Efficacy Study NCT01117870
Pulsed RadioFrequency; Placebo
Chronic Lumbar Radicular Pain
Not yet Rec
32 Adt Sen
Jun-10 Aug-11 McMaster Uni. http://ClinicalTrials.gov/show/NCT01117870
72
Clinical Prediction Rule for Clinical Lumbar Instability Single Group Assignment, Efficacy Study NCT01085448
Core Stabilization Low Back Pain, Mechanical
Rec 60 Adt Mar-10 Aug-11 Drexel Uni. http://ClinicalTrials.gov/show/NCT01085448
Effects of Mattress Firmness on Pain in Patients With Chronic Low-Back Pain Crossover Assignment NCT01044121
Mattress Firmness Low Back Pain; Sleep Disruption
Rec 40 Adt Jan-10 Jul-11 Sleep To Live Institute; Duke Uni.
http://ClinicalTrials.gov/show/NCT01044121
Traditional Chinese Medicine in Routine care of Orthopaedic Rehabilitation - sustainability and acceptance by patients of the German Pension Fund RCT (active) ISRCTN40932605
Traditional Chinese Medicine
Chronic back pain; Osteoarthritis
Active 520 Adt Jan-09 Jun-11 Refonet, Germany http://www.controlled-trials.com/ISRCTN40932605
Chiropractic Management of Chronic Lower Back Pain in Older Adults RCT (active), Efficacy Study NCT00475787
Spinal Manipulation Chronic Low Back Pain
Rec 216 Adt Sen
Apr-08 Jun-11 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00475787
The effect of ultrasound as a treatment for long lasting low back pain. RCT (placebo) NTR2251
Continuous therapeutic ultrasound + semi-supervised exercise program; placebo ultrasound + semi-supervised exercise program
Chronic non-specific low back pain
Active 50 Adt Sen?
May-10
May-11
Tehran University Medical School
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2251
Epidural Steroid Injection Versus Epidural Steroid Injection and Manual Physical Therapy and Exercise in the Management of Lumbar Spinal Stenosis; a Randomized Clinical Trial Randomized, Parallel Assignment NCT00786981
Epidural steroid injection plus physical therapy; Epidural steroid injection
Lumbar Spinal Stenosis
Rec 80 Adt Sen
Apr-09 May-11
Franklin Pierce Uni.; Uni. of Colorado, Denver
http://ClinicalTrials.gov/show/NCT00786981
Classification algorithm for low back pain. RCT (active) NTR1176
Classification algorithm; usual care
Non-specific low back pain
Active 150 Adt Sen?
Apr-08 Apr-11 VU University Medical Centre; EMGO Institute, The Netherlands
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1176
73
Dose of Spinal Manipulation for Chronic Low Back Pain Phase II/III: RCT (dose comparison), Efficacy Study NCT00376350
Spinal Manipulation; Light Massage; Pulsed Ultrasound
Low Back Pain Rec 400 Adt Sen
Mar-07 Mar-11 Uni. of Western States; National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT00376350
Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy? RCT (active), Efficacy Study NCT00826124
Epidural steroid injection; Magnetic Resonance Imaging (MRI)
Lumbosacral Radiculopathy
Active NR
131 Adt Sen
Jan-09 Feb-11 Johns Hopkins Uni.; Walter Reed Army Medical Center
http://ClinicalTrials.gov/show/NCT00826124
Ultrasound Guided Diagnostic Lumbar Medial Branch Blocks Single Group Assignment, Safety/Efficacy Study NCT00909272
Lumbar medial branch block; Ultrasound landmarks
Back Pain Not yet Rec
25 Adt Jul-09 Jan-11 Hamilton Health Sciences
http://ClinicalTrials.gov/show/NCT00909272
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use RCT (active) NCT01050465
Health information prescription
Range of conditions
6
including Back Pain; Fibromyalgia; Knee Pain; OA; Senile Osteoporosis and Shoulder Pain
Invite 728 Adt Sen
May-09
Dec-10 Uni. of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT01050465
Prognostic Value of Hyperexcitability of the Central Hypersensitivity in Patients With Acute Low Back Pain Observational: Prospective, Cohort Study NCT00892411
Parameters of central hypersensitivity; Spinal cord hyperexcitability; Descending modulation and cortical reorganization
Pain Measurement; Low Back Pain
Rec 140 Adt Sen
Feb-09 Dec-10 Uni. Hosp Inselspital, Berne
http://ClinicalTrials.gov/show/NCT00892411
6 Acne Vulgaris; Allergic Rhinitis; Anxiety; Asthma; Prostatic Hyperplasia; Bursitis; Chronic Obstructive Pulmonary Disease; Cough; Coronary Artery Disease; Depression; Diabetes Mellitus;
Diarrhea; Gastroesophageal Reflux; Headache; HIV Infections; Hypothyroidism; Hyperlipidemia; Hypertension; Influenza; Sleep Initiation and Maintenance Disorders; Irritable Bowel Syndrome; Migraine Disorders; Obesity; Obstructive Sleep Apnea; Colonoscopy; Mammography; Sinusitis; Smoking Cessation; Tobacco Use Cessation; Menopause; Urinary Incontinence; Urinary Tract Infection; Vaccination; Vaginitis; Vertigo
74
Osteopathic Treatment of Low Back Pain Observational: Prospective, Cohort Study NCT00883987
Low Back Pain Rec 10 Adt Jun-09 Dec-10 Capital District Health Authority, Canada
http://ClinicalTrials.gov/show/NCT00883987
Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients Phase II: RCT (placebo), Efficacy Study NCT00830596
HVLA-SM; LVVA-SM; light effleurage followed by SMT
Low Back Pain Rec 219 Adt Jul-07 Dec-10 Palmer College of Chiropractic; National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00830596
Chiropractic and Self-care for Back-Related Leg Pain RCT (active), Efficacy Study NCT00494065
Home exercise; Chiropractic Spinal Manipulative Therapy + Home exercise
Sub-acute and Chronic Back-related Leg Pain
Active NR
192 Adt Sen
Jun-07 Oct-10 Northwestern Health Sciences Uni.; Department of Health and Human Services
http://ClinicalTrials.gov/show/NCT00494065
Individualized Chiropractic and Integrative Care for Low Back Pain RCT (active), Efficacy Study NCT00567333
Chiropractic care; Multidisciplinary, integrative care
Sub-Acute and Chronic Low Back Pain
Active NR
200 Adt Sen
Jun-07 Oct-10 Northwestern Health Sciences Uni.; Health Resources and Services Administration (HRSA); Berman Center for Outcomes and Clinical Research
http://ClinicalTrials.gov/show/NCT00567333
Efficacy of Different Acupuncture Methods for Chronic Low Back Pain RCT (active), Efficacy Study NCT00758017
Acupuncture 1; Acupuncture 2
Chronic Low Back Pain
Rec 150 Adt Sen
Jan-09 Sep-10 Charite Uni., Berlin, Germany
http://ClinicalTrials.gov/show/NCT00758017
Standardizing Management of Patients With Low Back Pain in Primary Care and Physical Therapy Phase III: RCT (active), Efficacy Study NCT00769626
Usual Care; Early Treatment
Back Pain; Low Back Pain
Rec 130 Adt Sep-08 Aug-10 Intermountain Health Care, Inc.
http://ClinicalTrials.gov/show/NCT00769626
75
Assessment of Acupuncture to Improve Function, Exercise Capacity, and Pain Phase I: Single Group Assignment, Efficacy Study NCT00502619
Acupuncture and treadmill exercise
Chronic Low Back Pain
Rec 16 Adt Sep-07 Aug-10 VA Maryland Health Care System; Samueli Institute for Information Biology
http://ClinicalTrials.gov/show/NCT00502619
The OSTEOPATHIC Trial: The OSTEOPAThic Health Outcomes In Chronic Low Back Pain Trial Phase III: RCT (placebo), Safety/Efficacy Study NCT00315120
Osteopathic manipulation + ultrasound physical therapy; Sham osteopathic manipulation + ultrasound physical therapy; Osteopathic manipulation + Sham ultrasound physical therapy; Sham osteopathic manipulation + sham ultrasound physical therapy
Low Back Pain Rec 488 Adt Sen
Aug-06 Jun-10 Uni. of North Texas Health Science Center; Osteopathic Research Center; National Institutes of Health (NIH); Osteopathic Heritage Foundations
http://ClinicalTrials.gov/show/NCT00315120
Chiropractic for Back and Neck Pain in an Emergency Department Setting Phase I/II: RCT (placebo), Efficacy Study NCT00964717
Real Chiropractic; Sham Chiropractic
Back Pain; Neck Pain; Anxiety
Rec 90 Adt May-09
May-10
Assaf-Harofeh Medical Center
http://ClinicalTrials.gov/show/NCT00964717
Acupuncture Analgesia in Relation to Psychiatric Comorbidity Phase III: RCT (placebo), Efficacy Study NCT00307788
Acupuncture Low Back Pain Active NR
60 Adt May-04
May-10
Brigham and Women's Hosp; National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00307788
Acupuncture for Back Pain: A Mixed Methods Observational Study Evaluating Patient Outcomes and Their Determinants Prospective, cohort study UKCRN ID 4857
Acupuncture Persistent back pain
N/K 500 Adt Sen
N/K May-10
Southampton University Hospitals NHS Trust
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4857
76
A Study to Evaluate Methods to Evaluate Back Pain Randomized, Parallel Assignment, Pharmacodynamics Study NCT01045993
Heat Device; placebo; Drug: marketed analgesic; sham
Pain Rec 60 Adt Jan-10 Apr-10 Wyeth http://ClinicalTrials.gov/show/NCT01045993
Implementing evidence based primary care for back pain Pre-post design ISRCTN55174281
Novel evidence-based clinical practice; current clinical practice
Low back pain Comp 1000 Adt Sen
Oct-07 Apr-10 Keele University, UK
http://www.controlled-trials.com/ISRCTN55174281
Learning to Improve the Management of Back pain In the Community Single Group Assignment ISRCTN30420389
GP practice training Back pain Comp 1000 Adt Oct-07 Mar-10 Bournemouth University, UK
http://www.controlled-trials.com/ISRCTN30420389
Improving the care for people with acute low-back pain by allied health professionals: a cluster randomised controlled trial RCT (active), Safety/Efficacy Study ACTRN12609001022257
Clinical guidelines underpinned by behavioural theory; usual care
Acute non-specific low back pain
N/K 2720 Adt Sen
Nov-09 > Feb-10
Monash University http://www.anzctr.org.au/trial_view.aspx?ID=320855
Assessment of Spinal Stability Observational: Cross-sectional, Case-Only NCT01060358
Method (non-surgical) to measure neuromuscular neutral zones
Spine Stability; Low Back Pain
Rec 25 Adt Aug-09 ? Jan-10
Uni. of Colorado, Denver
http://ClinicalTrials.gov/show/NCT01060358
Acupuncture for Back and Neck Pain in an Emergency Room Setting Phase I/II: RCT (placebo), Efficacy Study NCT00859365
Real Acupuncture; Placebo Acupuncture; No intervention
Back Pain; Neck Pain; Anxiety; Range of Motion
Rec 90 Adt Jan-09 Jan-10 Assaf-Harofeh Medical Center
http://ClinicalTrials.gov/show/NCT00859365
A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain Randomized, Parallel Assignment NCT00732394
MSDR Chronic Low Back Pain
Rec 200 Adt Aug-08 Jan-10 MedAppraise, Inc. http://ClinicalTrials.gov/show/NCT00732394
77
Multiple Emergency Department Acupuncture Trials. (MEDACT) RCT (active) ACTRN12609000989246
Acupuncture; Pharmacologic treatment
Low back pain; Acute migraine; Ankle pain
N/K 505 Adt Sen
Dec-09 > Dec-09
Royal Melbourne Institute of Technology
http://www.anzctr.org.au/trial_view.aspx?ID=320815
Guideline Implementation in Physiotherapy Non-Randomized, Parallel Assignment NCT00962169
Behavioral and managerial; Behavioral and IT
Low Back Pain Rec 30 Child Adt Sen
Jul-09 Dec-09 Radboud Uni. http://ClinicalTrials.gov/show/NCT00962169
Assessing Patient Response to Therapeutic Exercise Based on Clinical Prediction Rule (CPR) for Spinal Manipulation Phase III: Randomized, Crossover Assignment, Efficacy Study NCT00916734
Spinal manipulation; MDT (McKenzie Method)
Low Back Pain Rec 40 Adt Sen
Nov-07 Dec-09 Daemen College http://ClinicalTrials.gov/show/NCT00916734
Effectiveness of Percutaneous Lumbar Epidural Adhesiolysis and Neurolysis on Low Back Pain RCT (active), Safety/Efficacy Study NCT00370994
Percutaneous adhesiolysis with hypertonic saline neurolysis (anesthetic, steroid, 10% sodium chloride solution)
Chronic Low Back Pain
Comp 320 Adt Sen
Jan-06 Dec-09 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT00370994
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response Non-Randomized, Parallel Assignment, Efficacy Study NCT00601341
Lumbosacral joint manipulation; Lumbar passive range of motion; No active intervention
Knee Pain; Hip Pain; Ankle Pain; Lumbopelvic Pain
Rec 276 Adt May-05
Dec-09 University of Virginia
http://ClinicalTrials.gov/show/NCT00601341
Measurement of Substance P in Saliva of Low Back Pain Patients Parallel Assignment (historical) NCT00735735
The taking of a saliva sample from each subject.
Low Back Pain Rec 40 Adt Sen
Feb-09 Oct-09 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00735735
Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain Single Group Assignment NCT00487266
Acupuncture Low Back Pain Rec 180 Adt Sep-06 Sep-09 National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00487266
78
Effect of Massage on Chronic Low Back Pain Phase II/III: RCT (active), Efficacy Study NCT00371384
Massage Chronic Low Back Pain (Non-specific, uncomplicated)
Active NR
399 Adt Aug-06 Sep-09 National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00371384
Chiropractic Dosage for Lumbar Stenosis Phase II: RCT (placebo), Safety/Efficacy Study NCT00527527
Flexion distraction; Placebo control
Lumbar Spinal Stenosis
Active, not Rec
60 Adt Sen
Sep-07 Aug-09 National University of Health Sciences; Foundation for Chiropractic Education and Research (FCER)
http://ClinicalTrials.gov/show/NCT00527527
Education/Exercise and Chiropractic for Chronic Back Pain RCT (active), Efficacy Study NCT00561652
Chiropractic treatment + Education + Exercise; Education + Exercise;
Low Back Pain Comp 30 Adt Sen
Apr-08 Jul-09 Department of Veterans Affairs; Northwestern Health Sciences Uni.
http://ClinicalTrials.gov/show/NCT00561652
Manual and Manipulative Therapy for Low Back Pain Randomized, Parallel Assignment, Efficacy Study NCT00632060
Manual / Manipulative Therapy (M/MT)
Low Back Pain Rec 100 Adt Feb-08 Jul-09 Samueli Institute for Information Biology
http://ClinicalTrials.gov/show/NCT00632060
The Effects of Short Arc Banding Phase I/II: Single Group Assignment, Efficacy Study NCT00885001
Short Arc Banding Chronic Low Back Pain
Rec 30 Adt Apr-09 May-09
Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00885001
Early physiotherapy for acute lower back pain in health care workers UKCRN ID 3292
Early physiotherapy Low back pain Active NR
50 Adt N/K May-09
Southampton City Primary Care Trust
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=3292
The Right Intervention for the Right Patient Randomized, Parallel Assignment, Efficacy Study NCT00459433
Biopsychosocial intervention
Low Back Pain Comp 300 Adt Oct-06 May-09
The Back Research Center, Denmark; European Commission
http://ClinicalTrials.gov/show/NCT00459433
79
Z-Joint Changes in Low Back Pain Following Adjusting RCT (dose comparison), Efficacy Study NCT00284063
Neurtral MRI (lumbar spine); side posture MRI; Neutral MRI; low back adjustment; neutral MRI; Neutral MRI; low back adjustment; side posture MRI; Neutral MRI; side posture position; neutral MRI
Mechanical Low Back Pain
Comp 112 Adt Sen
Feb-06 ? May-09
National Uni. of Health Sciences
http://ClinicalTrials.gov/show/NCT00284063
Changes in Cerebral Blood Flow in Patients Treated With Spinal Cord Stimulation for Low Back and Leg Pain Phase IV: Single Group Assignment, Safety/Efficacy Study NCT00418301
Precision Spinal Cord Stimulation and PET Scan
Pain; Low Back Pain; Leg Pain
Comp 15 Adt Sen
Jan-07 Apr-09 Boston Scientific Corporation
http://ClinicalTrials.gov/show/NCT00418301
Driving out back pain in business drivers UKCRN ID 3293
? Process of care Back pain N/K 60 N/K N/K Apr-09 Loughborough University
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=3293
Traditional Acupuncture and Myofascial Trigger Point Dry Needling and Acupressure for Chronic Low Back Pain RCT (active), Efficacy Study NCT00804089
Traditional needle acupuncture; Myofascial trigger point dry needling; Myofascial trigger point acupressure
Low Back Pain Rec 90 Adt Dec-08 Mar-09 Hermano Miguel Foundation; Ecuadorian Federation of Physiotherapy, Tungurahua Branch; Technical Uni. of Ambato
http://ClinicalTrials.gov/show/NCT00804089
Cross-Disciplinary Workplace Intervention Strategy for Chronic Musculoskeletal Disorders RCT (active), Efficacy Study NCT00369135
Combined intervention
Back Pain; Neck Pain; MSK Abnormalities
Rec 120 Adt Mar-06 Feb-09 Institut Universitaire Romand de Sante au Travail
http://ClinicalTrials.gov/show/NCT00369135
Unguided Sacroiliac Injection: Effect on Refractory Buttock Pain in Patients With Spondyloarthropathies Single Group Assignment, Safety/Efficacy Study NCT00829543
Guide-free sacroiliac corticosteroid injection
Spondyl-arthropathy
Invite 35 Child Adt
Sep-04 Feb-09 Tabriz Uni. http://ClinicalTrials.gov/show/NCT00829543
80
A pragmatic, single blind randomised controlled pilot study for professional kinesiology practice and back pain with initial feasibility study RCT (placebo) ISRCTN76057921
Kinesiology; Sham Kinesiology; Waiting list
Chronic and recurrent low back pain
Comp 150 Adt Sep-07 Jan-09 University of Southampton, UK
http://www.controlled-trials.com/ISRCTN76057921
Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation Randomized, Parallel Assignment, Efficacy Study NCT00484159
Radiofrequency denervation of medial branches + 0.5% bupivacaine + 2% lidocaine;
Low Back Pain Comp 151 Adt Sen
Feb-07 Jan-09 Johns Hopkins Uni. http://ClinicalTrials.gov/show/NCT00484159
The Effect of Chiropractic Manipulation on Spine-related Pain and Balance in Older Adults Single Group Assignment, Efficacy Study NCT00497718
Chiropractic Manipulation
MSK Equilibrium; Back Pain; Neck pain
Comp 75 Adt Sen
Feb-07 Dec-08 Cleveland Chiropractic College
http://ClinicalTrials.gov/show/NCT00497718
Energy Specific Far Infrared Radiation Treatment for Sciatica Phase I: Single Group Assignment, Efficacy Study NCT00573807
Radiation: Far Infrared Radiation (5μm to 20μm wavelength)
Sciatica Active NR
2 Child Adt Sen
Jan-06 Dec-08 GAAD Medical Research Institute Inc.
http://ClinicalTrials.gov/show/NCT00573807
Clinical Research on the Efficacy of Acupuncture Treatment in Chronic Low Back Pain NCT00815529
Acupuncture, Pak-sham needle
Chronic Low Back Pain; Acupuncture
Expand N/K Adult N/K ? Dec-08
Kyunghee Uni. Medical Center; Korea Health Industry Development Institute
http://ClinicalTrials.gov/show/NCT00815529
A Study of a Potential Mechanisms of Spinal Manipulation in the Treatment of Low Back Pain Phase I: Randomized, Parallel Assignment NCT00922220
Spinal manipulative therapy; Stationary bike; Lumbar extension exercise
Low Back Pain Comp 94 Adt Oct-04 Nov-08 Uni. of Florida http://ClinicalTrials.gov/show/NCT00922220
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain RCT (active), Efficacy Study NCT00939107
Spinal manipulation; McKenzie exercises
Low Back Pain Comp 350 Adt Sep-03 Nov-08 Back and Rehabilitation Center, Copenhagen
http://ClinicalTrials.gov/show/NCT00939107
81
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow Non-Randomized (historical), Efficacy Study NCT00634608
Health Information Prescription - MedlinePlus link
Range of conditions
7
including Back Pain; Osteoporosis (Senile); and Shoulder Pain
Active NR
400 Adt Sen
Feb-08 Oct-08 Uni. of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT00634608
Economic Evaluation of an Exercise Program After Multidisciplinary Rehabilitation in Patients With Chronic Low Back Pain Randomized, Parallel Assignment, Efficacy Study NCT00960583
Functional multidisciplinary rehabilitation; Exercise program; Routine follow-up
Chronic Low Back Pain
Comp 105 Adt Jan-05 Oct-08 Uni. of Lausanne http://ClinicalTrials.gov/show/NCT00960583
The Effect of Manipulations of the Lumbar Spine on Six Different Outcome Measures RCT (placebo), Safety/Efficacy Study NCT00739570
AAI signature IV AMCT
Low Back Pain Comp 20 Adt Sen
Jun-08 Aug-08 Universite du Quebec a Montreal
http://ClinicalTrials.gov/show/NCT00739570
Algometer and Category II Pelvic Blocking and Cranial Protocol Randomized, Parallel Assignment NCT00649753
Category II Pelvic Blocking; Category II Pelvic Blocking and Cranial; Cranial Only
Pain; Sacroiliac Joint Dysfunction
Comp 40 Adt Mar-08 Aug-08 Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00649753
A randomised controlled trial of Neuro Emotional Technique for chronic low back pain sufferers. RCT (active) ACTRN12608000002381
Neuro Emotional Technique (NET); Sham NET
Chronic low back pain
N/K 120 Adt Sen
Feb-08 > Aug-08
Macquarie University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=82488
A Pilot MRI Study of Osteopathic Manipulative Treatment of Acute Low Back Pain Single Group Assignment NCT00562562
Osteopathic manipulative treatment
Low Back Pain Rec 6 Adt Sep-07 Aug-08 Ohio Uni.; Collaborating institution: O'Bleness Memorial Hosp, Athens
http://ClinicalTrials.gov/show/NCT00562562
7 Allergic Rhinitis; Asthma; Benign Prostatic Hypertrophy; Bursitis; Depression; Anxiety; Diabetes Mellitus; Esophageal Reflux; HIV Infections; Hyperlipidemia; Hypertension; Insomnia; Irritable
Bowel Syndrome; Obesity; Sinusitis; Symptomatic Menopause; Urinary Incontinence; Urinary Tract Infection; Vaginitis
82
Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Phase IV: Single Group Assignment NCT00443781
Functional Anaesthetic Discography; Provocative discography
Low Back Pain Active NR
100 Adt Sen
Mar-07 ? Aug-08
Medtronic Spine LLC
http://ClinicalTrials.gov/show/NCT00443781
Stepped Care for Depression and Musculoskeletal Pain Phase IV: RCT (active), Efficacy Study NCT00118430
Stepped Care; Antidepressants; Self-management program; Usual Care
Pain, back, hip or knee; Depression
Active, NR
500 Adt Sen
Sep-04 Aug-08 National Institute of Mental Health (NIMH)
http://ClinicalTrials.gov/show/NCT00118430
Spinal Manipulative Therapy for Low Back Pain Phase IV: RCT (active), Efficacy Study NCT00294229
Manipulative therapy
Low Back Pain Active NR
102 Adt Apr-03 ? Aug-08
Uni. of Bern; Swiss Society for Manual Therapy; Uni. Hosp Inselspital, Berne; Wissen-schaftlicher Fonds WFR
http://ClinicalTrials.gov/show/NCT00294229
Integration of the traditional Chinese medicine into the orthopedic rehabilitation: effects on pain and employment prognosis for patients with chronic back pain RCT ISRCTN59155637
Traditional Chinese Medicine + orthopedic rehabilitation; orthopedic rehabilitation
Chronic back pain
Comp 270 Adt Jan-06 Jun-08 Refonet, Germany http://www.controlled-trials.com/ISRCTN59155637
Study Care Versus Usual Care for Acute Mechanical Lower Back Pain RCT (active), Pharmacokinetics Study NCT00135239
Study care; Usual care
Low Back Pain, Mechanical
Comp 88 Adt Jan-06 Jun-08 Uni. of British Columbia
http://ClinicalTrials.gov/show/NCT00135239
Exercise and manual auricular acupuncture: a single-blind, feasibility, randomised controlled trial exploring the effectiveness of a combined approach for chronic low back pain RCT ISRCTN94142364
Auricular acupuncture + individually tailored, supervised exercise; individually tailored supervised exercise
Chronic low back pain
Comp 80 Adt Jun-06 May-08
University of Ulster, UK
http://www.controlled-trials.com/ISRCTN94142364
83
Miscellaneous observational studies
Assessment of SpondyloArthritis Society (ASAS) Classification and Diagnostic Criteria for Early Axial Spondyloarthritis (SpA) Prospective, Cohort Study NCT00328068
Spondylo-arthritis; Spondyl-arthropathy; Spondylitis, Ankylosing
Rec 992 Adt Sen
Jul-06 Jun-13 Charite Uni., Berlin, Germany
http://ClinicalTrials.gov/show/NCT00328068
Cytology Study of Cells From Patients With Low Back Pain Prospective, Case-Only NCT01089478
Back Pain Rec 1500 Adt Sen
Apr-05 Apr-13 Texas Tech Uni. Health Sciences Center
http://ClinicalTrials.gov/show/NCT01089478
Low Back Pain Illness Trajectories: The BeBack Long Term Follow Up Study Cohort Study UKCRN ID 8184
Low back pain Not yet rec
810 Adt Sen
N/K May-12
Keele University http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=8184
Study of Cells From Spinal Cavity of Patients With Low Back Pain Prospective, Case-Only NCT01089491
Low Back Pain Rec 50 Adt Sen
Mar-10 Dec-11 Texas Tech Uni. Health Sciences Center
http://ClinicalTrials.gov/show/NCT01089491
Association Between Low Back Pain and Quality of Sleep Prospective NCT00906152
Quality of Sleep; Subacute or Chronic Low Back Pain; Disability; Catastrophizing; Depression
Rec 420 Child Adt Sen
Sep-09 Sep-11 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00906152
The Influence of Different Factors on Workers' Disability Due to Low Back Pain Prospective NCT00667316
Low Back Pain Rec 7200 Adt Feb-08 Mar-11 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00667316
Back Pain Prevalence in Wheelchair Users and Associated Risk Factors Cross-Sectional NCT00477568
Back Pain Rec 350 Adt Sen
Nov-07 Dec-10 Kovacs Foundation; Instituto de Asuntos Sociales y Deportes de Mallorca
http://ClinicalTrials.gov/show/NCT00477568
84
The Influence of Coping Strategies and Catastrophizing on Patients With Back and Neck Pain Prospective, Cohort Study NCT00502333
Back Pain; Neck Pain
Rec 1400 Adt Sen
Nov-06 Dec-10 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00502333
Patterns of Cerebral Activation to Innocuous and Noxious Heat Stimulations in Neuropathic Pain Cross-Sectional, Cohort NCT00713024
Neuropathic Pain
Rec 150 Adt Sen
Jan-08 Dec-10 National Taiwan Uni. Hosp
http://ClinicalTrials.gov/show/NCT00713024
Spinal Cord Stimulation Research Study Prospective, Case-Only NCT00768872
Chronic Low Back and Leg Pain
Rec 33 Adt Sen
Oct-08 Oct-10 MedtronicNeuro http://ClinicalTrials.gov/show/NCT00768872
Diagnostic accuracy of recently proposed criteria for inflammatory back pain (IBP) in suspected ankylosing spondylitis (AS) and early axial spondyloarthritis (axial SpA) Prospective
Inflammatory back pain; Chronic back pain; Ankylosing spondylitis; Axial spondyloarthritis
Active 550 Adt Sen
Sep-08 Aug-10 Charite – University Medicine Berlin, Germany
http://www.controlled-trials.com/ISRCTN66488490
Clinical assessment of patients with low back-related leg pain in primary care. A consensus study Cross-sectional UKCRN ID 8065
Sciatica; Low back pain; Leg pain
Active 120 Adt Sen
N/K Aug-10 Keele University http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=8065
Prevalence of Back Pain and Associated Risk Factors in 10-12 Year Old Schoolchildren Cross-Sectional NCT00666419
Measurement, weight, and muscle strength test
Low Back Pain Rec 8000 Child Sep-06 Jun-10 Kovacs Foundation; Universitat de les Illes Balears
http://ClinicalTrials.gov/show/NCT00666419
Prevalence of MODIC Changes in Subjects With and Without Low Back Pain Cross-Sectional NCT00479063
Low Back Pain Rec 292 Adt May-08
May-10
Kovacs Foundation http://ClinicalTrials.gov/show/NCT00479063
WHODAS-II for Patients With Nonspecific Low Back Pain Control: Uncontrolled; Single Group Assignment, Efficacy Study NCT00479245
Set of questionnaires (respondent)
Low Back Pain Rec 200 Adt Sen
Apr-07 May-10
Kovacs Foundation http://ClinicalTrials.gov/show/NCT00479245
85
Lumbar Stenosis Outcomes Research (LUSTOR) Phase IV Prospective, Cohort Study NCT00638443
Neurogenic Intermittent Claudication; Lumbar Spinal Stenosis
Rec 37 Adt Sen
Mar-08 May-10
Uni. of Rochester; Pfizer
http://ClinicalTrials.gov/show/NCT00638443
Association of Modic Changes With Chronic Low Back Pain Cross-Sectional NCT00478868
Low Back Pain Rec 219 Adt May-08
Apr-10 Kovacs Foundation http://ClinicalTrials.gov/show/NCT00478868
Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320) Prospective, Cohort Study NCT00726765
Spinal Spondylo-arthropathies; Axial Spondyloarthritis
Active NR
1000 Adt Sen
Jun-08 Apr-10 Schering-Plough http://ClinicalTrials.gov/show/NCT00726765
Screening of Instability of the Spinal Column With Spinal Mouse® and x-Ray Cross-sectional, Case-Only NCT00837538
Instability of Lumbar Spine
Not yet Rec
100 Adt Sen
Feb-09 Feb-10 JyväskyläCentral Hosp
http://ClinicalTrials.gov/show/NCT00837538
Low Back Pain Illness Trajectories. The BaRNS Long Term Individual and Family Follow Up Study Cohort Study UKCRN ID 7005
Low back pain Active NR
358 Adt Sen
N/K Dec-09 Keele University http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=7005
Rehabilitation of Dynamic Muscle, Back Pain and Postural Balance Retrospective, Case Control NCT01011270
Low Back Pain Invite 82 Adt
M-only
Jul-09 Nov-09 Universidade Castelo Branco
http://ClinicalTrials.gov/show/NCT01011270
Assessment of a Specific Neurophysiological Brain Pattern in Patients Suffering From Chronic Back Pain Prospective, Case Control NCT00744575
Back Pain Active NR
72 Adt Sen
Aug-08 Oct-09 Uni. Hosp Freiburg http://ClinicalTrials.gov/show/NCT00744575
Changing perceptions of work ability in people with low back pain: feasibility and economic evaluation (phase 2) UKCRN ID 7086
Low back pain Active NR
50 N/K N/K Oct-09 University of Nottingham
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=7086
86
Validating PROMIS Instruments in Back and Leg Pain Prospective, Case-Only NCT00784251
Leg Pain; Back Pain
Rec 185 Adt Sen
Jul-08 Jul-09 National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT00784251
Genetic Determinants of Ankylosing Spondylitis Severity NCT00056849
Ankylosing Spondylitis
Rec 2000 Adt Sen
Mar-03 ? Jul-09
National Institute of Arthritis and Musculoskeletal and Skin Diseases
http://ClinicalTrials.gov/show/NCT00056849
Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study NCT00056719
Ankylosing Spondylitis
Rec 2000 Adt Sen
Mar-03 ? Jul-09
National Institute of Arthritis and Musculoskeletal and Skin Diseases
http://ClinicalTrials.gov/show/NCT00056719
Dunedin Acute Back Pain Study: Identifying patients at risk to develop chronic low back pain Prospective, Longitudinal Study ACTRN12608000520336
Acute low back pain
N/K 800 Adt Nov-08 > May-09
University of Otago; South Link Health Inc, Dunedin, New Zealand
http://www.anzctr.org.au/trial_view.aspx?ID=83218
Spinal Cord Stimulation Research Study Prospective NCT00737581
Chronic Low Back and Leg Pain.
Comp 30 Adt Sen
Aug-08 Apr-09 MedtronicNeuro http://ClinicalTrials.gov/show/NCT00737581
An investigation into the predictive relationships between physical activity and recovery in a population with acute low back pain Prospective, Longitudinal Study ACTRN12609000282280
Acute low back pain
N/K 80 Adt Mar-08 > Mar-09
University of Otago, New Zealand
http://www.anzctr.org.au/trial_view.aspx?ID=83740
French Validation Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ) Questionnaire Prospective, Cohort Study NCT00706043
Acute Low Back Pain; Chronic Low Back Pain
Not yet Rec
120 Adt Jun-08 ? May-08
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
http://ClinicalTrials.gov/show/NCT00706043
Causes of Low Back Pain in Nurses in Israeli Hospitals Prospective, Cohort Study NCT00681096
Low Back Pain Not yet Rec
350 Adt Sen
Jun-08 ? May-08
Hillel Yaffe Medical Center
http://ClinicalTrials.gov/show/NCT00681096
Changing perceptions of work ability in people with low back pain: feasibility and economic evaluation UKCRN ID 5122
Low back pain Active NR
30 N/K N/K Mar-09 University of Nottingham
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=5122
87
A6: HIP PAIN
Title Phases: study design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Developing an active management booklet for hip and knee pain: an interventional single centre randomised controlled trial RCT (active) ISRCTN24554946
New educational booklet; Patient information regarding osteoarthritis
Hip pain; Knee pain (inclusion not dependent on diagnosis of OA)
Comp 200 Adt Sen
Jan-09 Jun-09 Cardiff University, UK.
http://www.controlled-trials.com/ISRCTN24554946
Drugs including biologics
Osteonecrosis of the Hip and Bisphosphonate Treatment Phase IV: RCT (placebo), Efficacy Study NCT00781261
Zoledronic Acid; Placebo
Osteonecrosis Rec 120 Adt Aug-09 Dec-13 University of Sydney; Novartis
http://ClinicalTrials.gov/show/NCT00781261
Steroid Injection for the Treatment of Greater Trochanteric Pain Syndrome Phase IV: RCT (placebo), Efficacy Study NCT00863889
Depomedrol injection; Lidocaine, Marcaine
Bursitis Rec 50 Child Adt Sen
Mar-09 Feb-10 Emory University http://ClinicalTrials.gov/show/NCT00863889
Other including CAM therapies
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response Non-Randomized, Parallel Assignment, Efficacy Study NCT00601341
Lumbosacral joint manipulation; Lumbar passive range of motion; No active intervention
Knee Pain; Hip Pain; Ankle Pain; Lumbopelvic Pain
Rec 276 Adt May-05
Dec-09 University of Virginia
http://ClinicalTrials.gov/show/NCT00601341
88
Stepped Care for Depression and Musculoskeletal Pain Phase IV: RCT (active), Efficacy Study NCT00118430
Stepped Care; Antidepressants; Self-management program; Usual Care
Pain, back, hip or knee; Depression
Active, NR
500 Adt Sen
Sep-04 Aug-08 National Institute of Mental Health (NIMH)
http://ClinicalTrials.gov/show/NCT00118430
Miscellaneous observational studies
Development of Outcome-Measures for Physically Active Patients With Hip and Groin Pain Prospective NCT00716729
Hip Disability; Groin Disability
Not yet Rec
150 Adt Sen
Jan-09 Dec-10 Amager Hospital; Lundbeck Foundation
http://ClinicalTrials.gov/show/NCT00716729
Prevalence of Femoroacetabular Impingement in Asymptomatic Patients Prospective Cohort Study NCT00606047
Femoroacetabular Hip Impingement Syndrome
Active, NR
200 Child Adt Sen
Aug-07 ? Sep-09
Ottawa Hospital Research Institute
http://ClinicalTrials.gov/show/NCT00606047
A7: KNEE PAIN
Title Phases: study design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
A single centre non-randomised interventional trial of physiotherapy-led exercise versus care as usual for knee pain in older adults in primary care Non-randomized, parallel assignment ISRCTN23294263
Physiotherapy-led exercise; usual care
Knee pain or stiffness
Comp 30 Adt Sen
Sep-09 May-10
Keele University http://www.controlled-trials.com/ISRCTN23294263
89
Developing an active management booklet for hip and knee pain: an interventional single centre randomised controlled trial RCT (active) ISRCTN24554946
New educational booklet; Patient information regarding osteoarthritis
Hip pain; Knee pain (inclusion not dependent on diagnosis of OA)
Comp 200 Adt Sen
Jan-09 Jun-09 Cardiff University, UK.
http://www.controlled-trials.com/ISRCTN24554946
Drugs including biologics
Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy Phase II: Single Group Assignment, Safety/Efficacy Study NCT01111773
Heated Lidocaine and Tetracaine Topical Patch
Patellar Tendinopathy
Not yet Rec
20 Adt Sen
May-10
Sep-10 ZARS Pharma Inc. http://ClinicalTrials.gov/show/NCT01111773
A randomised controlled trial on the effect of zolendronic acid versus placebo on the amount of knee pain in patients with bone marrow oedema-associated knee pain. RCT (placebo) ACTRN12609000399291
Zolendronic acid IV; Saline IV
Knee pain Rec 60 Adt Sen
May-09
May-10
Menzies Research Institute, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=83922
Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-Traumatic Osteonecrosis of the Knee: A Randomized Double-Blind, Placebo-Controlled Trial Phase III: RCT (placebo), Efficacy Study NCT00532220
Ibandronate IV; Placebo
Osteonecrosis of the Knee; Bone Marrow Edema of the Knee
Rec 30 Adt Sen
Dec-07 May-09
University Hospital, Basel, Switzerland
http://ClinicalTrials.gov/show/NCT00532220
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis Phase III: RCT (placebo), Safety/Efficacy Study NCT00426985
Ketoprofen Topical Patch 20%
Tendonitis; Bursitis
Term 330 Adt Sen
Jan-07 Oct-08 Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00426985
90
Ibuprofen plus paracetamol in knee pain RCT (active) ISRCTN77199439
Ibuprofen 400mg; Paracetamol 100mg; Ibuprofen 200mg + Paracetamol 500mg
Knee pain Comp 800 Adt Sen
Jun-07 May-08
RB Corporate Services LTD, UK
http://www.controlled-trials.com/ISRCTN77199439
Other including CAM therapies
Treatment of Medial Compartmental Osteoarthritis Grade 1-4 (According to Kellgren-Lawrence) or Osteonecrosis With TomoFix™ Small or Conservatively Prospective, Cohort Study NCT01048710
High tibial osteotomy; conservation treatment
Osteoarthritis, Knee; Osteonecrosis
Rec 148 Adt Sen
Jul-09 Feb-16 AO Clinical Investigation and Documentation; Synthes Inc.
http://ClinicalTrials.gov/show/NCT01048710
The effect of acupuncture on pain and physical function in patients with chronic knee pain: a randomised placebo-controlled trial. RCT (placebo), Efficacy Study ACTRN12609001001280
Needle Acupuncture; Laser Acupuncture; Sham laser acupuncture; Sham needle acupuncture
Chronic knee pain
Active 280 Adt Sen
Dec-09 > Dec-10
The University of Melbourne, UK
http://www.anzctr.org.au/trial_view.aspx?ID=308156
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use RCT (active) NCT01050465
Health information prescription
Range of conditions
8
including Back Pain; Fibromyalgia; Knee Pain; Osteoarthritis; Senile Osteoporosis; and Shoulder Pain
Invite 728 Adt Sen
May-09
Dec-10 University of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT01050465
8 Acne Vulgaris; Allergic Rhinitis; Anxiety; Asthma; Prostatic Hyperplasia; Bursitis; Chronic Obstructive Pulmonary Disease; Cough; Coronary Artery Disease; Depression; Diabetes Mellitus;
Diarrhea; Gastroesophageal Reflux; Headache; HIV Infections; Hypothyroidism; Hyperlipidemia; Hypertension; Influenza; Sleep Initiation and Maintenance Disorders; Irritable Bowel Syndrome; Migraine Disorders; Obesity; Obstructive Sleep Apnea; Colonoscopy; Mammography; Sinusitis; Smoking Cessation; Tobacco Use Cessation; Menopause; Urinary Incontinence; Urinary Tract Infection; Vaccination; Vaginitis; Vertigo
91
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response Non-Randomized, Parallel Assignment, Efficacy Study NCT00601341
Lumbosacral joint manipulation; Lumbar passive range of motion; No active intervention
Knee Pain; Hip Pain; Ankle Pain; Lumbopelvic Pain
Rec 276 Adt May-05
Dec-09 University of Virginia
http://ClinicalTrials.gov/show/NCT00601341
A randomised controlled trial to evaluate the effectiveness of insoles to treat anterior knee (patella femoral) pain RCT ISRCTN84641129
Orthaheel® regular; Sham insole
Anterior knee pain
Comp 100 Adt Mar-08 Jul-09 SSL International, UK
http://www.controlled-trials.com/ISRCTN84641129
Stepped Care for Depression and Musculoskeletal Pain Phase IV: RCT (active), Parallel Assignment NCT00118430
Stepped Care; Antidepressants; Self-management program; Usual Care
Pain, back, hip or knee; Depression
Active, NR
500 Adt Sen
Sep-04 Aug-08 National Institute of Mental Health (NIMH)
http://ClinicalTrials.gov/show/NCT00118430
Miscellaneous observational studies
The course of knee pain and knee osteoarthritis in community-dwelling adults aged 50 years and over. 6-year follow-up of the Clinical Assessment Study – Knee (CAS-K). Cohort study UKCRN ID 6083
Knee pain; Knee osteoarthritis
Open 835 Adt Sen
N/K Mar-10 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6083
How are decisions made about self-care for knee pain and disability? UKCRN 5137
Knee pain and disability
Active NR
30 N/K N/K Apr-09 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=5137
Knee Pain Progression and Risk Factors UKCRN ID 5640
Knee pain Active NR
5479 N/K N/K Aug-08 University of Nottingham
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=5640
Public Health models of prevention of knee pain and disability in older adults UKCRN ID 4224
Knee pain and disability
Active NR
40 N/K N/K Jun-08 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4224
92
A8: FOOT, ANKLE & TOE PAIN
Title Phases: study designs (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Device
Heel Cushion for Plantar Fasciitis Phase III: RCT (active), Efficacy Study NCT01017406
PSU heel cushion + plantar fascia specific stretching exercise
Plantar Fasciitis Not yet Rec
160 Child Adt
Jan-10 Apr-12 Prince of Songkla University
http://ClinicalTrials.gov/show/NCT01017406
A multicentre randomised controlled trial to determine the efficacy of a simple pressure-relieving insole compared to a sham insole RCT (placebo) ISRCTN02824122
Pressure relieving insoles; sham insole
Scleroderma; Foot pain; Foot problems
Active 140 Adt Sen
Jul-10 Dec-11 University of Leeds, UK
http://www.controlled-trials.com/ISRCTN02824122
Effectiveness of extracorporeal shock wave therapy in patients with proximal plantar fasciitis RCT ISRCTN49594569
Radial extracorporeal shockwave therapy – 3 or 6 sessions; No active treatment
Chronic plantar fasciitis
Active 68 Adt Sep-09 Sep-11 The Hong Kong Polytechnic University
http://www.controlled-trials.com/ISRCTN49594569
Efficacy of customised foot orthoses in improving pain, function and activity in people with Achilles tendinopathy undergoing an eccentric calf muscle exercise program RCT (placebo), Efficacy Study ACTRN12609000829213
Custom foot orthoses + eccentric exercise; Sham foot orthoses + eccentric exercise
Achilles tendinopathy
Active 140 Adt Jul-09 > Jul-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=320486
Effectiveness of radial shock wave treatment or tissue-specific plantar fascia-stretching in patients with chronic plantar heel pain RCT ISRCTN11644582
Radial shock wave therapy (RSWT); Plantar fascia-specific stretching (PFSS); RSWT + PFSS
Plantar fasciopathy
Comp 250 Adt Sen
Jul-07 Jan-10 OrthoTrauma Evaluation Centre, Germany
http://www.controlled-trials.com/ISRCTN11644582
93
A Randomized Controlled Trial of Custom Foot Orthoses for the Treatment of Plantar Heel Pain Randomized, Factorial Assignment, Efficacy Study NCT00765843
Orthoses Plantar Fasciitis Rec 300 Adt Sen
Oct-08 > Oct-09
Rosalind Franklin University of Medicine and Science; Advocate Health Care
http://ClinicalTrials.gov/show/NCT00765843
A randomized controlled trial to evaluate the effectiveness of insoles to treat plantar heel pain RCT (placebo) ISRCTN47272667
Orthaheel® regular; Orthaheel® gel heel pad; Sham insole
Plantar heel pain Comp 150 Adt Mar-08 Jul-09 SSL International, UK
http://www.controlled-trials.com/ISRCTN47272667
Plantar Fasciitis Treated With Dynamic Splinting RCT (active) NCT00650884
Ankle Dorsiflexion Dynasplint System
Plantar Fasciitis Comp 66 Adt Sen
Feb-08 Jan-09 Dynasplint Systems, Inc.
http://ClinicalTrials.gov/show/NCT00650884
Hallux Limitus Treated With Dynamic Splinting: A Randomized, Controlled Trial RCT (active) NCT00717691
Metatarso-phalangeal Extension Dynasplint System; Standard of Care
Hallux Limitus Comp 50 Adt Sen
Jul-08 Dec-08 Dynasplint Systems, Inc.
http://ClinicalTrials.gov/show/NCT00717691
Clinical Evaluation of Placement of Radiofrequency-Based Plasma Microdebridement in the Treatment Algorithm for Foot and Ankle Tendinosis and Plantar Fasciosis Phase IV: Single Group Assignment, Efficacy Study NCT00420875
TOPAZ MicroDebrider
Plantar Fasciosis, Achilles Tendinosis
Wtdwn 90 Adt Jun-07 ? Oct-08
ArthroCare Corporation
http://ClinicalTrials.gov/show/NCT00420875
Bracing and Strengthening for Posterior Tibial Tendon Dysfunction Phase II: RCT (placebo), Efficacy Study NCT00756457
Bracing; Strengthening exercises
Posterior Tibial Tendon Dysfunction
Comp 50 Adt Sen
Jul-07 Sep-08 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00756457
Plantar Fascia-Specific Stretching (PFSS) versus Radial Shock Wave Therapy (SWT) as Initial Treatment of Plantar Fasciopathy RCT (active) ISRCTN03438342
Plantar Fascia-Specific Stretching; Radial Shock Wave Therapy
Plantar Fasciopathy
Comp 100 Adt Sen
Aug-05 Aug-08 OrthoTrauma Evaluation Centre, Germany
http://www.controlled-trials.com/ISRCTN03438342
94
Exercise and Shoe Orthoses in Treatment of Posterior Tibial Tendon Dysfunction Phase I: RCT (active) NCT00279630
Orthoses and Behavioural: Exercise
Tendinopathy Rec 45 Adt Sen
Jun-02 Aug-08 University of Southern California
http://ClinicalTrials.gov/show/NCT00279630
Plantar Fasciosis Treatment Using Coblation Phase IV: RCT (active), Efficacy Study NCT00189592
ArthroCare TOPAZ™ MicroDebrider™ using Coblation; Surgical Fasciotomy
Plantar Fasciosis; Plantar Fasciitis
Comp 45 Adt Sen
Aug-05 Jun-08 ArthroCare Corporation
http://ClinicalTrials.gov/show/NCT00189592
Drugs including biological
Achilles Tendinopathy Management: a randomised controlled trial comparing platelet-rich plasma with an eccentric loading programme RCT ISRCTN95369715
Platelet Rich Plasma injection; eccentric loading exercise programme
Achilles tendinopathy
Active 20 Adt Sen
Feb-10 Feb-12 University of Warwick
http://www.controlled-trials.com/ISRCTN95369715
Comparison of oral prednisolone and oral indometacin in the treatment of acute gout-like arthritis: a multicentre double-blind randomised trial RCT ISRCTN45724113
Prednisolone; Indometacin
Gouty arthritis Active 400 Adt Sen
Jan-10 Dec-11 Health, Welfare and Food Bureau, Hong Kong
http://www.controlled-trials.com/ISRCTN45724113
PRP to Treat Plantar Fasciitis Phase IV: RCT (active), Efficacy Study NCT00758641
PRP obtained with GPS; Kenacort 40 mg/ml triamcinolon acetonide
Plantar Fasciitis Rec 120 Adt Sen
Sep-09 Dec-11 Biomet, Inc.; St. Elisabeth Hospital, Tilburg, Netherlands; Diaconessenhuis Leiden Netherlands; Biomet Nederland BV
http://ClinicalTrials.gov/show/NCT00758641
95
A double blind, randomised, placebo controlled, multicentre trial of Anti-Tumour Necrotising Factor alpha (Anti-TNFα) chimeric monoclonal antibody (infliximab, Remicade®) in combination with methotrexate in patients with very early inflammatory arthritis RCT ISRCTN21272423
Symptomatic therapy + methotrexate + infliximab; Symtomatic therapy + methotrexate + placebo; Symptomatic therapy + placebo
Early arthritis (hand or foot involvement)
Active 200 Adt Sen
Sep-07 Sep-11 Medical Unviersity of Vienna, Austria
http://www.controlled-trials.com/ISRCTN21272423
Treatment of Plantar Fasciitis With Platelet Rich Plasma RCT (active), Efficacy Study NCT01127672
Platelet rich plasma; Corticosteroid injection
Plantar Fasciitis Not yet Rec
50 Adt Sen
May-10
May-11
Loma Linda University
http://ClinicalTrials.gov/show/NCT01127672
Ultrasound guided corticosteroid injection for plantar fasciitis: a randomised controlled trial RCT (placebo), Efficacy Study ACTRN12610000239066
Ultrasound guided dexamethasone sodium phosphate injection; Ultrasound guided saline injection
Plantar fasciitis Not yet Rec
80 Adt Sen
May-10
> Aug-10
La Trobe University http://www.anzctr.org.au/trial_view.aspx?ID=335277
NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control Leg Stiffness and Functional Recovery in Athletes Phase IV: RCT (active), Efficacy Study NCT00792376
Etoricoxib; Diclofenac
Achilles Tendinopathy
Not yet Rec
56 Adt
M-only
Jan-09 Apr-10 Argentine Tennis Association
http://ClinicalTrials.gov/show/NCT00792376
Placebo-Controlled Trial, Testing the Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles Tendinopathy Phase IV: RCT (placebo), Efficacy Study NCT00377910
Aethoxysclerol Chronic Achilles Tendinopathy
Rec 48 Adt Sen
Feb-07 Feb-10 Northern Orthopaedic Division, Denmark; University of Aarhus
http://ClinicalTrials.gov/show/NCT00377910
Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00447876
Botulinum type A toxin (Dysport®)
Chronic Plantar Fasciitis
Comp 40 Adt Sen
Jul-05 Apr-09 Ipsen http://ClinicalTrials.gov/show/NCT00447876
96
Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis Phase III: RCT (placebo), Safety/Efficacy Study NCT00642382
Agilus; Normal saline
Osteoarthritis Term 17 Adt Sen
Apr-08 Dec-08 Carticept Medical, Inc
http://ClinicalTrials.gov/show/NCT00642382
The effectiveness of intra-articular hyaluronan (Synvisc®) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus) RCT (placebo), Efficacy Study ACTRN12607000654459
Hylan GF-20 injection; Saline
OA, 1st
metatatarso-phalangeal joint
N/K 150 Adt Sen
Mar-08 Sep-08 La Trobe University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=82484
Randomised Clinical Trial of Prolotherapy Injections and Eccentric Loading Exercises for Painful Achilles Tendinosis RCT ACTRN12607000276459
Prolotherapy injection + eccentric exercise; eccentric exercise
Achilles Tendinosis
N/K 144 Adt Sen
Jun-07 Jun-08 Griffith University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=81557
Other including CAM therapies
Effectiveness of Podiatry on Plantar Pain Phase IV: RCT (active), Efficacy Study NCT00888394
Chiropody; Device:
Basic orthesis; Advantage orthesis; Chiropody and Advantage orthesis
Heel Pain; Plantar Fasciitis; Plantar Pain
Active, NR
312 Adt Sep-09 May-11
University of Malaga
http://ClinicalTrials.gov/show/NCT00888394
Hyperpronation and Foot-Pains Randomized, Parallel Assignment, Safety/Efficacy Study NCT00736138
Training and pellots?
Arthrosis in Knee Rec 50 Adt Sen
Jan-07 Dec-10 Northern Orthopaedic Division, Denmark
http://ClinicalTrials.gov/show/NCT00736138
Pathological processes and candidate interventions in mechanically induced foot pain UKCRN ID 6050
N/K Foot pain Active 60 N/K N/K May-10
Chapel Allerton Hospital, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6050
Treatment of forefoot problems in the elderly: a randomised controlled trial of standardised shoe advice versus podiatric treatment. RCT (active) NTR2212
Podiatric treatment; Shoe advice education
Forefoot pain Active 200 Adt Sen
Mar-10 Mar-13 EMGO Institute, The Netherlands
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2212
97
Multiple Emergency Department Acupuncture Trials. (MEDACT) RCT (active) ACTRN12609000989246
Acupuncture; Pharmacologic treatment
Low back pain; Acute migraine; Ankle pain
N/K 505 Adt Sen
Dec-09 > Dec-09
Royal Melbourne Institute of Technology
http://www.anzctr.org.au/trial_view.aspx?ID=320815
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response Non-Randomized, Parallel Assignment, Efficacy Study NCT00601341
Lumbosacral joint manipulation; Lumbar passive range of motion; No active intervention
Knee Pain; Hip Pain; Ankle Pain; Lumbopelvic Pain
Rec 276 Adt May-05
Dec-09 University of Virginia
http://ClinicalTrials.gov/show/NCT00601341
Miscellaneous observational studies
The Clinical Assessment Study of the Foot (CAS-F) Cohort Study UKCRN ID 8257
Foot pain Not yet Rec
5000 Adt Sen
N/K Sep-13 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=8257
98
A9: FIBROMYALGIA
Title Phases: trial design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Exercise-based Motivational Interviewing for Fibromyalgia RCT (placebo), Efficacy Study NCT00573612
Attention Control Counseling; Motivational Interviewing
Fibromyalgia Rec 200 Adt Dec-07 Dec-12 Indiana University http://ClinicalTrials.gov/show/NCT00573612
Nutrition and Coping Education for Symptom and Weight Management for Fibromyalgia Phase II: RCT (active), Efficacy Study NCT00925431
Lifestyle Modification; Supportive education
Fibromyalgia; Obesity
Rec 80 Adt Aug-09 Dec-11 University of Utah http://ClinicalTrials.gov/show/NCT00925431
Improving Quality of Life of Fibromyalgia Patients RCT (active), Efficacy Study NCT00715195
Plurifocal educational program; Information
Fibromyalgia Rec 100 Adt Sep-07 Dec-11 Assistance Publique - Hopitaux de Paris; Fondation de France
http://ClinicalTrials.gov/show/NCT00715195
Drug and Talk Therapy for Fibromyalgia Phase IV: RCT (dose comparison), Efficacy Study NCT01038323
CBT + Milnacipran; CBT + placebo; Educational + milnacipran
Fibromyalgia Rec 48 Adt Dec-09 Nov-11 Indiana University; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT01038323
Influence of Pain physiolgy Education on the Pain Inhibition in Fibromyalgia. RCT (active) NCT00857740
Education Fibromyalgia Rec 50 Adt Mar-09 Mar-11 Vrije Universiteit Brussel
http://ClinicalTrials.gov/show/NCT00857740
Effect of One Week Self-management Program in Patients With Fibromyalgia Randomized, Parallel Assignment, Efficacy Study NCT01035125
Self-management program
Fibromyalgia Rec 150 Adt Sen
Dec-08 Mar-11 Revmatis-mesykehuset AS
http://ClinicalTrials.gov/show/NCT01035125
99
Use of guided imagery in patients diagnosed with fibromyalgia: effects on pain, self-efficacy and functional status. RCT (active) NTR2172
Guided imagery; group sessions
Fibromyalgia Active 70 N/K Nov-09 Dec-10 Fonds NutsOhra http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2172
A Pilot Study of Amygdala Retraining Program in Patients With Chronic Fatigue Syndrome, Chronic Fatigue and Fibromyalgia Randomized, Parallel Assignment, Efficacy Study NCT01046370
Amygdala Retraining Program
Chronic Fatigue Syndrome; Chronic Fatigue; Fibromyalgia
Invite 30 Adt Oct-09 Jul-10 Mayo Clinic http://ClinicalTrials.gov/show/NCT01046370
Cognitive Behavioral Insomnia Therapy for Individuals With Fibromyalgia Phase II/III: RCT (placebo), Efficacy Study NCT00321451
CBT for insomnia; Pseudo-desensitization procedure; Usual care
Fibromyalgia; Sleep Initiation and Maintenance Disorders
Rec 111 Adt May-06
Jul-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00321451
Subgroups of Fibromyalgia Syndrome (FMS): Symptoms, Beliefs, and Tailored Treatment Phase II: Randomized, Parallel Assignment NCT00762125
CR+ST; ET; AC treatment
Fibromyalgia Rec 235 Adt
F-only
Dec-05 Jun-10 National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT00762125
Lifestyle Physical Activity to Reduce Pain and Fatigue in Adults With Fibromyalgia RCT (active), Efficacy Study NCT00383084
Lifestyle physical activity (LPA); Fibromyalgia education
Fibromyalgia Rec 160 Adt Sep-06 Jun-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00383084
Yoga for Fibromyalgia RCT (historical), Efficacy Study NCT00966732
Yoga of Awareness Program
Fibromyalgia Active, NR
56 Adt Sen
F-
only
Oct-09 Jun-10 Oregon Health and Science University
http://ClinicalTrials.gov/show/NCT00966732
Clinical trial examining effects of Monosodium glutamate (MSG) on Irritable Bowel Syndrome (IBS) and Fibromyalgia (FM) RCT (placebo), Safety Study NCT00829218
Glutamate additive-free diet; Placebo diet
Irritable Bowel Syndrome; Fibromyalgia
Active, NR
60 Adt Sen
Jan-09 May-10
Oregon Health and Science University; University of Arizona
http://ClinicalTrials.gov/show/NCT00829218
100
Nondrug Treatment Programs for Adults With Fibromyalgia Phase II: RCT (active), Efficacy Study NCT00088777
Behavioral coping skills training + physical therapy; Stress management education + physical therapy
Fibromyalgia Rec 300 Adt Jan-05 Apr-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00088777
Efficacy of a Psychoeducative Program for Improving Quality of Life in Fibromyalgic Patients [Study Protocol] RCT (active), Efficacy Study NCT00550966
Psychoeducative program in fibromyalgic patients
Fibromyalgia Invite 109 Adt Sen
Sep-07 Feb-10 Institut Catala de Salut
http://ClinicalTrials.gov/show/NCT00550966
Effectiveness of the psychological and pharmacological treatment of catastrophisation in patients with fibromyalgia: a controlled randomised trial RCT ISRCTN10804772
Psychological intervention including CBT; Pregabalin (with duloxetine if necessary); usual care
Fibromyalgia Comp 180 Adt Sep-08 Dec-09 The Carlos III Health Institute, Spain
http://www.controlled-trials.com/ISRCTN10804772
Physical Exercise and Its Impact on Signs of Inflammation in Fibromyalgia RCT (active), Safety/Efficacy Study NCT00643006
Physical exercise; Active comparator: low intensive exercise
Physical Function Rec 70 Adt
F-only
Jan-08 Dec-09 Göteborg University http://ClinicalTrials.gov/show/NCT00643006
Comparative effect of two supervised exercise programs on key health outcomes in women with fibromyalgia syndrome RCT ISRCTN43742447
Aerobic exercise sessions; Aerobic and muscle strengthening exercise sessions
Fibromyalgia Comp 54 Adt Sen
Sep-07 Dec-09 University of Seville, Spain
http://www.controlled-trials.com/ISRCTN43742447
Stretching and Strengthening Exercise in Fibromyalgia Patients Randomized, Parallel Assignment NCT01029041
Strengthening Exercises; Stretching exercises
Fibromyalgia Syndrome
Comp 63 Adt
F-only
Aug-07 Nov-09 University of Sao Paulo General Hospital
http://ClinicalTrials.gov/show/NCT01029041
A Computer-Based Intervention for Medically Unexplained Physical Symptoms RCT (placebo), Efficacy Study NCT00468013
Resilience Building Exercises; Journaling
Fibromyalgia; Irritable Bowel Syndrome; Chronic Fatigue Syndrome
Active, NR
60 Adt Sen
Mar-07 Sep-09 University of Medicine and Dentistry New Jersey
http://ClinicalTrials.gov/show/NCT00468013
101
A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Phase IV: RCT (active), Efficacy Study NCT00965601
Cognitive Behavioral Therapy
Fibromyalgia Comp 30 Adt
F-only
Jul-08 Aug-09 Indiana University http://ClinicalTrials.gov/show/NCT00965601
Tai Chi Mind-Body Therapy for Fibromyalgia RCT (placebo), Safety/Efficacy Study NCT00515008
12-week Tai Chi Program.; 12-week Stretching and Wellness Education Program
Fibromyalgia Active, NR
60 Adt Sen
Jun-07 May-09
Tufts Medical Center; National Center for Complementary and Alternative Medicine (NCCAM); American College of Rheumatology Research and Education Foundation
http://ClinicalTrials.gov/show/NCT00515008
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain Phase II: RCT (placebo), Efficacy Study NCT00176163
Operant behavioral treatment; Drug: THC
Fibromyalgia; Back Pain
Comp 240 Adt Sen
Aug-05 May-09
University of Heidelberg, Germay
http://ClinicalTrials.gov/show/NCT00176163
Healing Through Affective Self-Awareness in Fibromyalgia: a Randomized Controlled Trial RCT (active), Efficacy Study NCT00437411
Affective Self-Awareness workshop
Fibromyalgia Active, NR
66 Adt Sen
Apr-07 Apr-09 University of Michigan; St. John Providence Hospital; Blue Care Network of Michigan
http://ClinicalTrials.gov/show/NCT00437411
Sleep intervention in patients with fibromyalgia RCT ISRCTN87743899
Psychological intervention + current practice; current practice.
Fibromyalgia Comp N/K N/K Jul-06 Jan-09 Department of Health, UK
http://www.controlled-trials.com/ISRCTN87743899
Cognitive Behavioral Therapy Trial in Fibromyalgia Randomized, Parallel Assignment, Efficacy Study NCT01004458
CBT; Waiting list Fibromyalgia Comp 48 Adt
F-only
Jan-01 Dec-08 Uppsala University http://ClinicalTrials.gov/show/NCT01004458
102
Effectiveness of Dance on Patients With Fibromyalgia Randomized, Parallel Assignment, Efficacy Study NCT00961805
Dance Fibromyalgia Comp 80 Adt
F-only
Aug-07 Nov-08 Federal University of Sao Paulo
http://ClinicalTrials.gov/show/NCT00961805
HRV Biofeedback in Fibromyalgia RCT (placebo), Efficacy Study NCT00222274
RSA Biofeedback; EEG Biofeedback Condition
Fibromyalgia Syndrome
Active, NR
80 Adt
F-only
Jul-04 Sep-08 University of Medicine and Dentistry New Jersey; Arthritis Foundation
http://ClinicalTrials.gov/show/NCT00222274
The effect of education about pain on illness perceptions in patients with fibromyalgia: a randomised clinical trial with a six-month follow up RCT ISRCTN86684957
Information on pain & sensitisation; Information on possible effects of relaxation exercises and how to perform them. Both groups received follow up phone calls.
Fibromyalgia Comp 200 Adt Oct-08 Jun-08 University of Antwerp
http://www.controlled-trials.com/ISRCTN86684957
Web-Based Education to Enhance Fibromyalgia Management RCT (active), Efficacy Study NCT00423631
Cognitive-behavioral therapy
Fibromyalgia; Fibrositis
Active, NR
170 Adt Sen
Sep-06 Jun-08 University of Michigan
http://ClinicalTrials.gov/show/NCT00423631
Testing Mestinon and Exercise in Fibromyalgia Phase II: RCT (placebo) NCT00535587
Exercise + Pyridostigmine; Pyridostigmine + Placebo; Exercise + Attention control; Attention control + Placebo
Fibromyalgia Comp 178 Adt Sep-02 Jun-08 National Institute of Nursing Research (NINR)
http://ClinicalTrials.gov/show/NCT00535587
Health Promotion for Women With Fibromyalgia Randomized, Parallel Assignment, Efficacy Study NCT00596674
Lifestyle Counts; Attention Control
Fibromyalgia Active, NR
177 Adt Sen
F-
only
Jul-03 May-08
University of Texas at Austin; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
http://ClinicalTrials.gov/show/NCT00596674
103
Device
Transcutaneous Electrical Nerve Stimulation (TENS) and Fibromyalgia (FM) Randomized, Crossover Assignment NCT00932360
Transient Placebo TENS (Rehabilicare Maxima TENS); Active TENS (Rehabilicare Maxima TENS); No TENS
Fibromyalgia Rec 50 Adt Sen
Jun-09 Jun-12 University of Iowa; Orthopedic Section of the American Physical Therapy Association
http://ClinicalTrials.gov/show/NCT00932360
Study of Mattress Type in Fibromyalgia Phase II: Randomized, Crossover Assignment, Efficacy Study NCT01108718
Brand name mattress; Comparison mattress
Fibromyalgia Rec 12 Adt Sen
F-
only
Jul-09 Oct-10 Beth Israel Medical Center
http://ClinicalTrials.gov/show/NCT01108718
The efficacy of cranial electrotherapy stimulation for the reduction of pain in fibromyalgia RCT (placebo) ACTRN12609000711213
Cranial electrotherapy; Sham therapy
Fibromyalgia Active 30 Adt Sen
Aug-08 > Sep-09
Pacific Medistim, Queensland
http://www.anzctr.org.au/trial_view.aspx?ID=308352
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain Phase II: RCT (placebo), Safety/Efficacy Study NCT00524420
rTMS; Sham rTMS Fibromyalgia; Chronic Pain; Depression
Rec 44 Adt
F-only
Feb-08 Sep-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); University of Washington
http://ClinicalTrials.gov/show/NCT00524420
Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia Phase I: Single Group Assignment, Safety/Efficacy Study NCT00294281
Vagus Nerve Stimulation (VNS) Therapy
Fibromyalgia Active, NR
40 Adt Oct-06 Jun-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases
http://ClinicalTrials.gov/show/NCT00294281
Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia Phase I/II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00928720
Cranial electrical stimulation (CES) device (Alpha-Stim); sham device
Fibromyalgia Rec 57 Adt Sen
Jun-09 May-10
University of Virginia
http://ClinicalTrials.gov/show/NCT00928720
104
Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders Phase III: RCT (placebo), Efficacy Study NCT00374673
Repetitive transcranial magnetic stimulation
Fibromyalgia; Irritable Bowel Syndrome; Burning Mouth Syndrome
Rec 90 Adt Sen
Oct-06 Jan-10 Hôpital Ambroise Paré
http://ClinicalTrials.gov/show/NCT00374673
Occipital Transcranial Direct Current Stimulation in Fibromyalgia Phase I/II: RCT (placebo), Safety/Efficacy Study NCT00947622
Transcranial direct current stimulation
Fibromyalgia Rec 35 Adt
F-only
Jul-09 Nov-09 University Hospital, Antwerp
http://ClinicalTrials.gov/show/NCT00947622
Occipital Nerve Stimulation in Fibromyalgia Phase II: Crossover Assignment (placebo) NCT00917176
Occipital nerve stimulation
Fibromyalgia Comp Adt
F-only
NK ? Jun-09
University Hospital, Antwerp
http://ClinicalTrials.gov/show/NCT00917176
Pain Relief Investigation of Neuromodulation Therapy in an Adult Fibromyalgia Population Phase III: RCT (placebo), Safety/Efficacy Study NCT00450905
PRIMA Device Fibromyalgia; Pain
Term 200 Adt Sen
Mar-07 Dec-08 Fralex Therapeutics; PharmaNet; McDougall Scientific Limited
http://ClinicalTrials.gov/show/NCT00450905
Dietary Supplement
Treatment of Chronic Fatigue Syndrome and Fibromyalgia With D-ribose: a Multicenter Study Single Group Assignment, Safety/Efficacy Study NCT01108549
Ribose Fibromyalgia; Chronic Fatigue Syndrome
Comp 257 Adt Sen
Apr-09 Sep-09 Kona Research Center; Bioenergy Life Science, Inc.; Integrative Therapeutics Inc
http://ClinicalTrials.gov/show/NCT01108549
The Role of Ribose in Patients Diagnosed With Fibromyalgia Randomized, Parallel Assignment NCT00566514
D-ribose; dextrose Fibromyalgia Susp 200 Adt Sen
Jul-06 Jul-08 Bioenergy Life Science, Inc.
http://ClinicalTrials.gov/show/NCT00566514
105
Drugs including biologics
Pregabalin In Adolescent Patients With Fibromyalgia Phase IV: Single Group Assignment, Safety Study NCT01020526
Pregabalin Fibromyalgia Not yet Rec
162 Child Adt
Jul-10 Jul-13 Pfizer http://ClinicalTrials.gov/show/NCT01020526
Pediatric Fibromyalgia Study Phase IV: Randomized, Parallel Assignment, Safety/Efficacy Study NCT01020474
Pregabalin, Placebo
Fibromyalgia Not yet Rec
162 Child Apr-10 Jan-13 Pfizer http://ClinicalTrials.gov/show/NCT01020474
Double Blind Trial of Duloxetine in Chronic Fatigue Syndrome Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00375973
Duloxetine Fatigue Syndrome, Chronic
Rec 60 Adt Sep-06 Dec-11 University of Cincinnati; Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00375973
A Study for Adult Patients With Fibromyalgia Phase IV: RCT (placebo), Safety/Efficacy Study NCT00965081
Duloxetine; Placebo Fibromyalgia, Primary; Fibromyalgia, Secondary
Rec 308 Adt Sen
Sep-09 Aug-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00965081
Randomized, Double-Blind, Placebo-Controlled Study Of Pregabalin In Patients With Fibromyalgia Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00830167
Pregabalin; Placebo
Fibromyalgia Rec 498 Adt Sen
Mar-09 Jul-11 Pfizer http://ClinicalTrials.gov/show/NCT00830167
An fMRI Study Of Brain Response In Patients With Fibromyalgia Phase I: Randomized, Crossover Assignment, Pharmacodynamics Study NCT00760474
Pregabalin, then placebo; Placebo, then pregabalin
Fibromyalgia Rec 24 Adt Sen
F-
only
Jan-09 Jun-11 Pfizer http://ClinicalTrials.gov/show/NCT00760474
Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Phase IV: Randomized, Parallel Assignment, Safety/Efficacy Study NCT01077375
Milnacipran; Placebo
Fibromyalgia Rec 100 Adt Sen
Feb-10 Mar-11 Forest Laboratories; Cypress Bioscience, Inc.
http://ClinicalTrials.gov/show/NCT01077375
106
Fibromyalgia Health Outcome Study on Cost of Treatments Observational: Prospective Cohort Study NCT00725101
Treatment for Fibromyalgia
Fibromyalgia Rec 1700 Adt Sen
Jun-08 Mar-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00725101
A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin In Patients With Fibromyalgia Phase III: Single Group Assignment, Safety Study NCT00830128
Pregabalin Fibromyalgia Rec 250 Adt Sen
Jul-09 Feb-11 Pfizer http://ClinicalTrials.gov/show/NCT00830128
A Study for Adolescents With Fibromyalgia Syndrome Phase IV: Single Group Assignment NCT01089621
Duloxetine Fibromyalgia Rec 20 Child Mar-10 Jan-11 Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT01089621
Cyclobenzaprine Extended Release (ER) for Fibromyalgia Phase IV: RCT (placebo), Efficacy Study NCT01041495
Cyclobenzaprine ER (AMRIX); placebo
Fibromyalgia; Pain; Sleep; Fatigue
Rec 60 Adt Jun-09 Dec-10 State University of New York - Upstate Medical University; Cephalon
http://ClinicalTrials.gov/show/NCT01041495
Pilot study to investigate the endocrinological, physiological and pain reducing effects of gamma hydroxybutyric acid in combination with operant behaviour pain therapy on patients with FibroMyalgia Syndrome RCT (placebo) ISRCTN01680675
Gamma hydroxybutyric acid alongside operant behaviour therapy; placebo
Fibromyalgia Active 40 Adt Sen
Oct-06 Dec-10 Charite – University Medicine Berlin
http://www.controlled-trials.com/ISRCTN01680675
Neurotropin to Treat Fibromyalgia Phase II: RCT (placebo), Safety/Efficacy Study NCT00366535
Neurotropin Fibromyalgia Rec 36 Adt Sen
F-
only
Aug-06 Dec-10 National Institute of Nursing Research (NINR)
http://ClinicalTrials.gov/show/NCT00366535
107
Safety and Tolerability Study Comparing Sodium Oxybate Given as an Oral Solution to a Single-blinded Combination of Oral Tablets Plus Oral Solution in Subjects With Fibromyalgia Phase III: Single Group Assignment, Safety Study NCT00803023
Sodium Oxybate; Sodium Oxybate & Tablet; Sodium Oxybate Oral Solution (6 grams)
Fibromyalgia Rec 120 Adt Sen
Mar-10 Dec-10 Jazz Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00803023
Study of T3 for the Treatment of Fibromyalgia Non-Randomized, Crossover Assignment, Efficacy Study NCT00903877
T3 Fibromyalgia Rec 20 Adt May-09
Dec-10 Stanford University http://ClinicalTrials.gov/show/NCT00903877
Maintenance of Efficacy. Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00796601
Esreboxetine; Placebo
Fibromyalgia Wtdwn 650 Adt Sen
May-09
Nov-10 Pfizer http://ClinicalTrials.gov/show/NCT00796601
Growth Hormone in Neuroendocrine Dysfunction With Severe Fibromyalgia Phase III: Randomized, Crossover Assignment, Safety/Efficacy Study NCT00933686
Somatropine; Placebo
Fibromyalgia Active, NR
123 Adt Sen
F-
only
Dec-07 Nov-10 EMD Serono http://ClinicalTrials.gov/show/NCT00933686
Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Phase IV: RCT (placebo), Efficacy Study NCT00755521
Etoricoxib Fibromyalgia Not yet Rec
80 Adt Sen
F-
only
Sep-08 Oct-10 Meir Medical Center
http://ClinicalTrials.gov/show/NCT00755521
Effect of Milnacipran in Patients With Fibromyalgia Phase II: RCT (placebo), Efficacy Study NCT01108731
Minalcipran; Placebo
Fibromyalgia Rec 45 Adt Mar-10 Aug-10 Beth Israel Medical Center; Forest Laboratories
http://ClinicalTrials.gov/show/NCT01108731
108
Efficacy and safety of eslicarbazepine acetate as therapy in patients with fibromyalgia: A double-blind, randomised, placebo-controlled, parallel-group, multicentre clinical trial RCT (placebo) UKCRN ID 6969 & NTR2167
Eslicarbazepine acetate
Fibromyalgia Active 480 Adt Sen
Apr-09 Aug-10 Bial Portela & Ca, S.A
http://public.ukcrn.org.uk/Search/ StudyDetail.aspx?StudyID=6969 http://www.trialregister.nl/trialreg/ admin/rctview.asp?TC=2167
Study of Indoleamine 2,3-dioxygenase Activity and Mirtazapine Efficacy in Fibromyalgia Syndrome Phase IV: RCT (placebo), Safety/Efficacy Study NCT00919295
Mirtazapine; placebo
Fibromyalgia Syndrome
Rec 216 Adt Sen
Dec-08 Aug-10 Mahidol University; University of Texas
http://ClinicalTrials.gov/show/NCT00919295
Pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in fibromyalgia RCT (active) NTR1343
Ketamine (I.V.); Midzolam (I.V.)
Fibromyalgia Active 24 N/K Feb-10 Jul-10 Leiden University Medical Center
http://www.trialregister.nl/trialreg/ admin/rctview.asp?TC=1343
Effects of Low Dose Naltrexone in Fibromyalgia Randomized, Crossover Assignment, Efficacy Study NCT00568555
Naltrexone Fibromyalgia; Persian Gulf Syndrome
Active, NR
60 Adt Jun-07 Jun-10 Stanford University; American Fibromyalgia Syndrome Association
http://ClinicalTrials.gov/show/NCT00568555
Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia Phase IV: RCT (placebo), Efficacy Study NCT01014585
Milnacipran; Placebo
Fibromyalgia Active, NR
425 Child Adt Sen
Nov-09 Jun-10 Forest Laboratories; Cypress Bioscience, Inc.
http://ClinicalTrials.gov/show/NCT01014585
Effects of Pregabalin (Lyrica) on Sleep Maintenance in Subjects With Fibromyalgia Phase III: Randomized, Crossover Assignment, Efficacy Study NCT00883740
Pregabalin; Placebo
Fibromyalgia; Sleep Disorders
Active, NR
100 Adt Sen
Jun-09 Jun-10 Pfizer http://ClinicalTrials.gov/show/NCT00883740
109
Fibromyalgia Treatment Trial With Gabapentin and Osteopathic Manipulative Medicine Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT01107574
Gabapentin and Osteopathic Manipulative Medicine; Gabapentin; Osteopathic Manipulative Medicine
Fibromyalgia Comp 41 Adt Apr-04 Apr-10 Good Samaritan Regional Medical Center, Oregon
http://ClinicalTrials.gov/show/NCT01107574
Safety and Efficacy of AGN 203818 for Pain Associated With Fibromyalgia Syndrome Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00445705
AGN 203818; Placebo
Fibromyalgia Active, NR
650 Adt Sen
F-
only
Apr-07 Apr-10 Allergan http://ClinicalTrials.gov/show/NCT00445705
Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia Phase IV: RCT (active), Safety/Efficacy Study NCT00766350
Amitriptyline; quetiapine
Fibromyalgia Rec 90 Adt Sen
Nov-08 Mar-10 Universidad de Granada; AstraZeneca; Hospital Clinico Universitario San Cecilio
http://ClinicalTrials.gov/show/NCT00766350
Safety and Efficacy Study of Xyrem® (Sodium Oxybate) in Subjects With Fibromyalgia. Phase III: Single Group Assignment, Non-Randomized (active), Safety/Efficacy Study NCT00423605
Xyrem® Fibromyalgia Active, NR
561 Adt Sen
Dec-06 Mar-10 Jazz Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00423605
The effect of ketamine on inhibitory pain mechanimsm in the central nervous system in chronic pain patients. RCT (active) NTR2005
Ketamine (I.V.) Fibromyalgia; Complex Regional Pain Syndrome; Central neuropathic pain
N/K 60 Adt Sen
Jan-09 Jan-10 Leiden University Medical Center
http://www.trialregister.nl/trialreg/ admin/rctview.asp?TC=2005
Study of Milnacipran Added to Pregabalin for Treatment of Fibromyalgia Phase III: RCT (active), Safety/Efficacy Study NCT00797797
Pregabalin; milnacipran
Fibromyalgia Comp 364 Adt Sen
Nov-08 Jan-10 Forest Laboratories http://ClinicalTrials.gov/show/NCT00797797
110
Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Phase IV: RCT (placebo), Efficacy Study NCT00983320
Quetiapine; placebo Fibromyalgia Rec 55 Adt
F-only
Apr-08 Jan-10 Universitaire de Sherbrooke; University of Montreal
http://ClinicalTrials.gov/show/NCT00983320
An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Phase IV: RCT (placebo), Safety/Efficacy Study NCT00678691
Armodafinil; placebo
Fibromyalgia, Primary
Rec 60 Adt Aug-07 Dec-09 State University of New York - Upstate Medical University
http://ClinicalTrials.gov/show/NCT00678691
Quetiapine Compared With Placebo in the Management of Fibromyalgia RCT (placebo), Efficacy Study NCT00710918
Quetiapine; Placebo
Fibromyalgia Rec 42 Adt Jun-08 Dec-09 East Tennessee State University Research Foundation
http://ClinicalTrials.gov/show/NCT00710918
Effect of Milnacipran on Pain Processing and Functional Magnetic Resonance Imaging (fMRI) Activation Patterns in Patients With Fibromyalgia Phase III: RCT (placebo), Safety/Efficacy Study NCT00793520
Milnacipran, Placebo
Fibromyalgia Term 36 Adt Sen
Nov-08 Nov-09 Forest Laboratories http://ClinicalTrials.gov/show/NCT00793520
Evaluation of the Antinociceptive and Analgesic Effects of Milnacipran Phase II: RCT (placebo), Safety/Efficacy Study NCT00757679
Milnacipran Fibromyalgia Syndrome
Rec 80 Adt Sen
F-
only
Sep-06 Oct-09 Pierre Fabre Medicament
http://ClinicalTrials.gov/show/NCT00757679
Trazodone and Its Augmentation With Pregabalin in the Treatment of Fibromyalgia Phase IV: Single Group Assignment, Safety/Efficacy Study NCT00791739
Trazodone, Pregabalin
Fibromyalgia Comp 75 Adt Sen
Apr-08 Oct-09 Universidad de Granada
http://ClinicalTrials.gov/show/NCT00791739
111
A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome Phase IV: RCT (placebo), Safety/Efficacy Study NCT00675896
Quetiapine Fumarate Sustained Release; Placebo
Major Depression, Fibromyalgia
Rec 120 Adt Apr-07 Sep-09 Dr Alexander McIntyre Inc.
http://ClinicalTrials.gov/show/NCT00675896
Calcitonin in the Treatment of Fibromyalgia Phase IV: Randomized, Crossover Assignment, Safety/Efficacy Study NCT00754884
Salmon calcitonin; intranasal saline solution plus glycerol
Fibromyalgia Invite 40 Adt
F-only
Oct-08 Aug-09 Unidad de Investigacion en Enfermedades Cronico-Degenerativas
http://ClinicalTrials.gov/show/NCT00754884
A Study Comparing Duloxetine and Placebo in the Treatment of Fibromyalgia Phase IV: RCT (placebo), Safety/Efficacy Study NCT00673452
Duloxetine hydrochloride; placebo
Fibromyalgia Comp 513 Adt Sen
Jun-08 Jul-09 Eli Lilly and Company; Boehringer Ingelheim Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00673452
Phase 1 Thorough QT (TQT) Study in Young Healthy Volunteers Phase I: Randomized, Crossover Assignment, Safety Study NCT00809289
Esreboxetine; Placebo; Moxifloxacin
Fibromyalgia Comp 40 Adt Dec-08 Jul-09 Pfizer http://ClinicalTrials.gov/show/NCT00809289
Open Label Extension Study of [S,S]-Reboxetine in Patients With Fibromyalgia Phase III: Single Group Assignment, Safety/Efficacy Study NCT00754221
[S,S]-Reboxetine Fibromyalgia Term 800 Adt Sen
May-08
Jun-09 Pfizer http://ClinicalTrials.gov/show/NCT00754221
Long-Term OL Study of [S,S]-RBX in Patients With Fibromyalgia Phase III: Single Group Assignment, Safety Study NCT00607256
[S,S]-Reboxetine Fibromyalgia Term 500 Adt Sen
Nov-07 Jun-09 Pfizer http://ClinicalTrials.gov/show/NCT00607256
Armodafinil for Fibromyalgia Fatigue Phase III: RCT (placebo), Efficacy Study NCT00568919
Armodafinil; Placebo
Fibromyalgia; Fatigue
Comp 60 Adt Sep-07 Jun-09 State University of New York - Upstate Medical University; Martin Morell MD Arthritis Associates
http://ClinicalTrials.gov/show/NCT00568919
112
A Study To Assess Esreboxetine's Effect On Concentration, Memory, Decision Making And Problem Solving In Patients With Fibromyalgia. Phase II: Randomized, Crossover Assignment, Safety/Efficacy Study NCT00752505
Esreboxetine Fibromyalgia Comp 89 Adt Aug-08 Jun-09 Pfizer http://ClinicalTrials.gov/show/NCT00752505
A Safety and Efficacy Study of Xyrem® (Sodium Oxybate) to Treat Fibromyalgia. Phase III: RCT (placebo), Safety/Efficacy Study NCT00423813
Xyrem®; Placebo Fibromyalgia Comp 573 Adt Sen
Dec-06 Jun-09 Jazz Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00423813
A 14-Week, Multi-Center Study of [S,S]-Reboxetine in Patients With Fibromyalgia. Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00612170
[S,S]-Reboxetine; Placebo
Fibromyalgia Comp 1129 Adt Sen
Dec-07 May-09
Pfizer http://ClinicalTrials.gov/show/NCT00612170
Multi-Centre Randomised Double Blind Placebo Controlled Clinical Trial of the Effect of Neurotec in Fibromyalgia Syndrome RCT (placebo) ACTRN12609000065291
Neurotec; Placebo Fibromyalgia syndrome
Comp N/K Adt Sen
Nov-08 > Mar-09
Iran Rheumatology Center
http://www.anzctr.org.au/ trial_view.aspx?ID=83304
This Open-label Study Will Evaluate the Analgesic Effectiveness and Safety Measurement of Tramadol HCl/Acetaminophen in the Treatment of Pain for Fibromyalgia. Phase IV: Single Group Assignment, Safety/Efficacy Study NCT00766675
Ultracet (tramadol HCL/acetaminophen)
Pain; Fibromyalgia
Comp 82 Adt Sen
May-08
Mar-09 Johnson & Johnson Taiwan Ltd
http://ClinicalTrials.gov/show/NCT00766675
Eszopiclone in the Treatment of Insomnia and Fibromyalgia Phase IV: Randomized, Parallel Assignment, Efficacy Study NCT00392041
Eszopiclone; placebo
Fibromyalgia; Insomnia
Comp 95 Adt Aug-06 Mar-09 University of Medicine and Dentistry New Jersey; Sepracor, Inc.
http://ClinicalTrials.gov/show/NCT00392041
113
A Study Evaluating Desvenlafaxine Sustained Release (DVS SR) in Adult Female Outpatients With Fibromyalgia Phase II: Randomized, Parallel Assignment, Efficacy Study NCT00696787
Desvenlafaxine Sustained Release (DVS SR); Lyrica® (Pregabalin); Placebo
Fibromyalgia Term 125 Adt Sen
F-
only
Jun-08 Jan-09 Wyeth http://ClinicalTrials.gov/show/NCT00696787
A Safety and Efficacy Study of Xyrem® in Subjects With Fibromyalgia Phase III: RCT (placebo), Safety/Efficacy Study NCT00371137
Xyrem®; Placebo Fibromyalgia Comp 548 Adt Sen
Aug-06 Dec-08 Jazz Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00371137
Pramipexole ER vs. Placebo in Fibromyalgia Phase II: Parallel Assignment, Safety/Efficacy Study NCT00689052
Pramipexole ER Fibromyalgia Term 61 Adt Sen
Jul-08 Nov-08 Boehringer Ingelheim Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00689052
The Use of Rotigotine for Treatment of Reducing Signs and Symptoms of Fibromyalgia in Adults. Phase II: RCT (placebo), Safety/Efficacy Study NCT00464737
Rotigotine; Placebo Fibromyalgia Syndrome
Comp 230 Adt Mar-07 Nov-08 UCB, Inc. http://ClinicalTrials.gov/show/NCT00464737
FMS European Long-Term Study Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00757731
Milnacipran Fibromyalgia Syndrome
Active, NR
468 Adt Sen
Oct-06 Oct-08 Pierre Fabre Medicament
http://ClinicalTrials.gov/show/NCT00757731
Lidocaine on Manifestations of Fibromyalgia Phase I: Randomized, Parallel Assignment NCT00991848
Lidocaine Fibromyalgia; Chronic Pain
Comp 30 Adt Jan-05 Sep-08 Federal University of Sao Paulo
http://ClinicalTrials.gov/show/NCT00991848
Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical Trial NCT00071708
Duloxetine Hydrochloride
Major Depressive Disorder; Fibromyalgia; Diabetic Peripheral Neuropathic Pain; Generalized Anxiety Disorder
No longer
available
Adt Sen
N/K ? Jul-08
Eli Lilly and Company
http://ClinicalTrials.gov/show/NCT00071708
114
A Study Of Milnacipran In Patients With Fibromyalgia: Effects On 24 Hour Ambulatory Blood Pressure Monitoring Phase III: RCT (placebo), Safety Study NCT00618956
Milnacipran hydrochloride; Placebo
Fibromyalgia Comp 321 Adt Sen
Oct-07 Jul-08 Forest Laboratories; Cypress Bioscience, Inc.
http://ClinicalTrials.gov/show/NCT00618956
Multi-Centre Randomised Double Blind Placebo Controlled Clinical Trial of the Effect of Neurotec in Fibromyalgia Syndrome Single Group Assignment, Efficacy Study ACTRN12608000071325
Neurotec Fibromyalgia syndrome
Comp 10 Adt Sen
Apr-08 > Jun-09
Iran Rheumatology Center
http://www.anzctr.org.au/ trial_view.aspx?ID=82395
Efficacy of Dolasetron in Patients With Fibromyalgia Phase III: RCT (placebo), Safety/Efficacy Study NCT00820326
Dolasetron; Placebo
Fibromyalgia Comp 60 Adt Sen
Mar-04 Jun-08 University Hospital, Limoges
http://ClinicalTrials.gov/show/NCT00820326
Study of Milnacipran for the Treatment of Fibromyalgia Phase III: RCT (placebo), Safety/Efficacy Study NCT00314249
Milnacipran 100mg; Placebo
Fibromyalgia Comp 1025 Adt Sen
Apr-06 Jun-08 Forest Laboratories; Cypress Bioscience, Inc.
http://ClinicalTrials.gov/show/NCT00314249
The use of a natural medicine, S-adenolsylmethionine (SAM-e) in the treatment of Fibromyalgia and Chronic Fatigue Syndrome RCT (placebo), Efficacy Study ACTRN12607000377437
S-adenolsylmethionine (SAM-e); placebo
Fibromyalgia Com 120 Adt Sen
Sep-07 > Apr-08
Deakin University; Nutrition Care Pharmaceuticals
http://www.anzctr.org.au/ trial_view.aspx?ID=82153
Other including CAM therapies
Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET RCT (placebo), Efficacy Study NCT00697398
Transcranial stimulation
Fibromyalgia Rec 40 Adt Oct-08 Oct-11 Assistance Publique Hopitaux De Marseille
http://ClinicalTrials.gov/show/NCT00697398
115
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use RCT (active) NCT01050465
Health information prescription
Fibromyalgia, Knee Pain, Osteoarthritis, Shoulder Pain and other conditions
9
Invite 728 Adt Sen
May-09
Dec-10 University of Missouri-Columbia; National Library of Medicine (NLM)
http://ClinicalTrials.gov/show/NCT01050465
Fibromyalgia Acupuncture Study RCT (placebo), Safety/Efficacy Study NCT00882271
Acupuncture Fibromyalgia Active, NR
50 Adt Sen
Jan-08 Aug-10 Southern California University of Health Sciences
http://ClinicalTrials.gov/show/NCT00882271
Qigong For Treatment Of Fibromyalgia Single Group Assignment NCT00938834
CFQ Qigong Fibromyalgia Pain Not yet Rec
100 Adt Sen
Aug-09 Aug-10 Capital District Health Authority, Canada
http://ClinicalTrials.gov/show/NCT00938834
Developing Biomarkers for Fibromyalgia RCT (placebo) NCT00932061
Traditional Acupuncture; Sham Treatment
Fibromyalgia Rec 60 Adt Sen
Jun-08 May-10
University of Michigan; The Dana Foundation; Department of Defense
http://ClinicalTrials.gov/show/NCT00932061
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain RCT (placebo), Efficacy Study NCT00554320
tDCS; Chronic Pelvic Pain; Interstitial Cystitis; Post Traumatic Stress Disorder; Fibromyalgia; Irritable Bowel Syndrome
Comp 24 Adt
F-only
Jan-09 Jun-09 Summa Health System
http://ClinicalTrials.gov/show/NCT00554320
A Study to Compare Two Ways of Completing Pain and Sleep Questions and to Evaluate a New Daily Questionaire for Assessing Fatigue in Fibromyalgia Patients Randomized, Crossover Assignment NCT00819624
Interactive Voice Response System (IVRS); Personal Digital Assisstant (PDA)
Fibromyalgia Comp 185 Adt Sen
Jan-09 Mar-09 Pfizer http://ClinicalTrials.gov/show/NCT00819624
9 Acne Vulgaris; Allergic Rhinitis; Anxiety; Asthma; Back Pain; Prostatic Hyperplasia; Bursitis; Chronic Obstructive Pulmonary Disease; Cough; Coronary Artery Disease; Depression; Diabetes
Mellitus; Diarrhea; Gastroesophageal Reflux; Headache; HIV Infections; Hypothyroidism; Hyperlipidemia; Hypertension; Influenza; Sleep Initiation and Maintenance Disorders; Irritable Bowel Syndrome; Migraine Disorders; Obesity; Obstructive Sleep Apnea; Senile Osteoporosis; Colonoscopy; Mammography; Sinusitis; Smoking Cessation; Tobacco Use Cessation; Menopause; Urinary Incontinence; Urinary Tract Infection; Vaccination; Vaginitis; Vertigo
116
Multiple Symptoms Study: a feasibility study of a GP with special interest clinic for patients with multiple medically unexplained symptoms (MMUS) RCT ISRCTN63083469
Symptoms Clinic; Usual care
Medically unexplained disorders including fibromyalgia
Comp 120 Adt Oct-09 Apr-10 University of Edinburgh
http://www.controlled-trials.com/ISRCTN63083469
Benefits of Tanning in Fibromyalgia Patients Single Group Assignment, Efficacy Study NCT00447083
Ultraviolet Light Fibromyalgia Syndrome
Comp 19 Adt May-05
Sep-08 Wake Forest University
http://ClinicalTrials.gov/show/NCT00447083
Effectiveness of Acupuncture in Relieving Pain Due to Fibromyalgia Phase I/ II: Randomized, Parallel Assignment, Efficacy Study NCT00142597
Acupuncture Fibromyalgia Comp 80 Adt Sen
F-
only
May-05
May-08
University of Michigan; National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT00142597
Miscellaneous observational studies
Evaluation and Diagnosis of People With Pain and Fatigue Syndromes Observational: Prospective NCT00677157
Fatigue; Fibromyalgia;
Pain; Complex Regional Pain Syndrome; Reflex Sympathetic Dystrophy
Rec 1000 Adt Sen
May-08
N/K National Institute of Nursing Research (NINR)
http://ClinicalTrials.gov/show/NCT00677157
Observational Study of Control Participants for the MAPP Research Network Observational: Prospective Cohort Study NCT01098292
Fibromyalgia; Irritable Bowel Syndrome; Fatigue Syndrome, Chronic
Rec 630 Adt Sen
Dec-09 Dec-12 University of Pennsylvania; National Institute of Diabetes and Digestive and Kidney Diseases; University of Colorado, Denver
http://ClinicalTrials.gov/show/NCT01098292
117
Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine Observational: Prospective, Cohort Study NCT00740233
Gastrointestinal Diseases; Chronic Pain; Stress; Anxiety; Depression including fibromyalgia
Rec 1000 Adt Jun-08 Dec-10 University of California, Los Angeles; National Center for Complementary and Alternative Medicine
http://ClinicalTrials.gov/show/NCT00740233
Fibromyalgia Rehabilitation - Access and Classification of Subgroups Observational: Cross-sectional Study DRKS00000300
Fibromyalgia Active 300 Adt Sen
Jan-10 > Oct-10
Universitäts-klinikum Friekburg Abteilung Qualitätsmanagment und Sozialmedizin
http://drks-neu.uniklinik-freiburg.de/drks_web/ navigate.do?navigationId= trial.HTML&TRIAL_ID=DRKS00000300
Cognitive and Memory Function in Patients With Fibromyalgia Observational: Prospective, Cohort Study NCT00789178
Fibromyalgia; Cognitive Impairment
Not yet Rec
80 Adt Sen
Dec-08 Apr-10 Assaf-Harofeh Medical Center
http://ClinicalTrials.gov/show/NCT00789178
Association Between Hypermobility and Chronic Musculoskeletal Pain Observational: Cross-sectional, Case-control Study NCT01032863
Hypermobility, Joint; Arthralgia; Myofascial Pain Syndromes; Fibromyalgia; Pain Disorder
Comp 112 Adt Dec-09 Mar-10 Amrita Institute of Medical Sciences & Research Center
http://ClinicalTrials.gov/show/NCT01032863
Distraction from pain in Fibromyalgia, Arthritis and healthy volunteers Observational UKCRN ID 4779
Fibromyalgia; Pain; Arthritis
Active 48 N/K N/K Dec-09 N/K http://public.ukcrn.org.uk/Search/ StudyDetail.aspx?StudyID=4779
Determining How the Nervous System Processes Pain in Adults With Fibromyalgia Observational: Cross-sectional, Case-control Study NCT00496886
Fibromyalgia; Rheumatoid Arthritis
Active, NR
120 Adt
F-only
Apr-06 ? May-09
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00496886
Genetics of Fibromyalgia Observational: Retrospective, Family-Based Study NCT00071162
Fibromyalgia; Irritable Bowel Syndrome; Chronic Fatigue Syndrome; Depression
Active, NR
560 Child Adt Sen
Sep-99 ? Mar-09
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00071162
118
The Expectancy of Pain in Fibromyalgia, Osteoarthritis and Healthy Volunteers Observational UKCRN ID 4784
Fibromyalgia; OA Active 48 N/K N/K Dec-08 N/K http://public.ukcrn.org.uk/Search/ StudyDetail.aspx?StudyID=4784
A10: CHRONIC PAIN
Title Phases: trial design (control) CT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
Pain Catastrophizing as a Cause for Systemic Inflammation Observational: Prospective, Case Control Study NCT00823147
Pain Catastrophizing Induction
Chronic MSK Pain
Rec 60 Adt
F-only
Jan-09 Jun-20 Oregon Health and Science Uni.; Oregon Clinical and Translational Research Institute; Office of Research on Women's Health (ORWH)
http://ClinicalTrials.gov/show/NCT00823147
Chronic Pain and Opioid Dependence Assessment and Treatment Single Group Assignment, Efficacy Study NCT00727675
Integrated Cognitive Behavioral Therapy
Chronic Pain; Opioid Dependency
Rec 20 Adt Aug-08 Jul-15 Yale Uni.; National Institute on Drug Abuse (NIDA)
http://ClinicalTrials.gov/show/NCT00727675
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence Phase I/II: Randomized, Factorial Assignment, Efficacy Study NCT00634803
CBT; Educational Counseling; Drug: Buprenorphine
Opiate Dependence; Chronic Pain
Rec 76 Adt Sep-09 Aug-14 Yale Uni. http://ClinicalTrials.gov/show/NCT00634803
Telehealth Therapy for Chronic Pain Randomized, Paralled, Efficacy Study NCT01055639
In-Person Acceptance and Commitment Therapy; Telehealth Acceptance and Commitment Therapy
Chronic Pain Not yet Rec
196 Adt Sen
Feb-10 Sep-13 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT01055639
119
Pain and Substance Use Disorders Randomized, Efficacy Study NCT00982410
CBT; Educational supportive group
Chronic Pain Not yet Rec
128 Adt Sen
Apr-10 Apr-13 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00982410
Telephone Intervention for Pain Study (TIPS) Randomized, Parallel Assignment, Efficacy Study NCT00663663
Telephone-Delivered CBT; Telephone Delivered Education Intervention
Chronic Pain; Multiple Sclerosis; Amputation; Spinal Cord Injuries
Invite 160 Adt Sen
Sep-09 Dec-12 Uni. of Washington http://ClinicalTrials.gov/show/NCT00663663
Contextual Cognitive-Behavioural Therapy (CBT) for the Self-Management of Chronic Pain in the Community: A Feasibility Study Observational UKCRN ID 8111
Contextual CBT Chronic pain Not yet Rec
116 Adt Sen
N/K Mar-12 Bath Royal National Hospital for Rheumatic Diseases
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=8111
Effectiveness of a Training Program in Improving Coping Skills in People With Arthritis Pain Phase II/III: Randomized, Parallel Assignment, Efficacy Study NCT00636454
Coping skills training (CST) for chronic pain; Usual care
OA Rec 272 Adt Sen
May-08
Jan-12 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00636454
Training to improve analgesic prescription for chronic pain Non-randomized, controlled trial ISRCTN93882803
GP training in psychological flexibility; control
GPs treating patients with Chronic pain
Active 196 Adt Sen
Sep-09 Oct-11 University of Bath http://www.controlled-trials.com/ISRCTN93882803
Cognitive Behavioral Smoking Cessation Intervention for Adults With Chronic Pain Randomized, Parallel Assignment, Efficacy Study NCT01091090
CBT; Control Smoking Cessation
Rec 60 Adt Sen
Nov-09 Apr-11 Mayo Clinic http://ClinicalTrials.gov/show/NCT01091090
Prerecorded Autosuggestion in Long-standing Pain Intervention RCT (active), Efficacy Study NCT01039727
Care as usual + 5 specific CDs; Care as usual + email assistance + AoL + CDs
Pain Not yet Rec
100 Adt Sen
Dec-09 Dec-10 Free Uni. Medical Center
http://ClinicalTrials.gov/show/NCT01039727
Telephone-Delivered Cognitive Behavior Therapy for Chronic Pain RCT (active), Efficacy Study NCT00371267
CBT; Pain Education
Pain Active, NR
101 Adt Sen
Oct-06 Oct-10 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00371267
120
Cognitive Behavioral Therapy, Self-Efficacy, and Depression in Persons With Chronic Pain Retrospective NCT01055665
CBT Depression; Chronic Pain
Invite 138 Adt Sen
Oct-09 Sep-10 Mayo Clinic http://ClinicalTrials.gov/show/NCT01055665
Managing Unexplained Symptoms (chronic widespread pain) In primary Care: Involving traditional and Accessible New approaches RCT ISRCTN67013851
Telephone based CBT; prescribed exercise; telephone based CBT + exercise; Treatment as usual
Chronic Widespread Pain
Active 552 Adt Sen
Oct-07 Sep-10 University of Aberdeen
http://www.controlled-trials.com/ISRCTN67013851
Treatment Of Chronic Pain Using Real Time fMRI Phase II: RCT (placebo), Safety/Efficacy Study NCT00528346
Cognitive training using fMRI; Placebo
Chronic Pain Rec 144 Adt Sep-07 Aug-10 Omneuron; National Institute of Neurological Disorders and Stroke (NINDS)
http://ClinicalTrials.gov/show/NCT00528346
Evaluating a Chronic Pain Treatment Program Phase I: Single Group Assignment, Efficacy Study NCT00861302
Mind-body emotional awareness program
Chronic MSK Pain
Rec 100 Adt Sen
Sep-08 Aug-10 Wayne State Uni.; Blue Cross Blue Shield
http://ClinicalTrials.gov/show/NCT00861302
Improving Chronic Pain Treatment in Primary Care RCT (active), Efficacy Study NCT00129480
Assistance with Pain treatment
Pain; Chronic Disease; Depression
Active, NR
401 Adt Sen
Jan-06 Jul-10 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00129480
A Telephone Feedback System for Prevention of Chronic Pain Relapse Phase II: RCT (active), Efficacy Study NCT00266773
Chronic pain therapeutic interactive voice response (TIVR) system
Chronic Pain and Relapse Prevention
Rec 150 Adt Sen
Nov-05 Jul-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Uni. of Vermont; Fletcher Allen Health Care
http://ClinicalTrials.gov/show/NCT00266773
Using Functional MRI to Evaluate Cognitive Behavioral Therapy Treatment Response in Adults With Chronic Pain Phase I/II: RCT (active), Efficacy Study NCT00796536
Group CBT; Pain education
Chronic Pain Not yet Rec
40 Adt Sen
Jun-09 Jun-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00796536
121
Impact of a Course on Stress Reduction Single Group Assignment, Efficacy Study NCT00902863
Yoga Chronic Pain Terminated
5 Adt Sen
Feb-09 Mar-10 Hamilton Health Sciences
http://ClinicalTrials.gov/show/NCT00902863
Behavioral Treatments for Chronic Pain RCT (active), Efficacy Study NCT00371865
CBT; Acceptance-based therapy
Intractable Pain Comp 114 Adt Sen
Oct-06 Sep-09 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00371865
Piloting IVR (Interactive Voice Response) for Chronic Pain Treatment Single Group Assignment, Efficacy Study NCT00651924
IVR-based CBT Chronic Pain Comp 4 Adt Sen
Dec-08 Apr-09 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00651924
I Am Able: Population Based Rehabilitation in a Family Health Team Non-randomized, Parallel Assignment, Efficacy Study NCT00859638
Physiotherapy; Occupational Therapy; Capacity Building
Chronic Conditions; Arthritis; Diabetes; Hypertension; Chronic Pain
Active, NR
119 Adt Sen
May-08
Apr-09 Hamilton Health Sciences; Ontario Neurotrauma Foundation
http://ClinicalTrials.gov/show/NCT00859638
Effect of Music Therapy on Pain RCT (active), Efficacy Study NCT01020032
Individual receptive music therapy by “U sequence" method"
Chronic Pain Comp 87 Adt Sen
Sep-06 Dec-08 Association de Musicothérapie Applications et Recherches Cliniques
http://ClinicalTrials.gov/show/NCT01020032
Treatment of Insomnia Secondary to Chronic Pain RCT (active), Efficacy Study NCT00127790
CBT for Insomnia and/or Pain
Insomnia; Pain Active, NR
44 Adt Sen
Jun-05 Nov-08 Uni. of Rochester; National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health
http://ClinicalTrials.gov/show/NCT00127790
Cognitive group therapy in the treatment of catastrophizing in patients with chronic non-cancer pain. Cohort Study NTR1157
Cognitive Group therapy
MSK pain Comp 6 Adt Jan-08 Oct-08 University Hospital Maastricht
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1157
122
Cognitive Behavioral Therapy for Insomnia in Chronic Pain Patients Phase I: RCT (placebo) NCT00133601
CBT Insomnia; Chronic Pain
Comp 28 Adt Sen
Oct-04 Oct-08 National Institute of Nursing Research (NINR); National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT00133601
Device
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain Phase II: RCT (placebo), Safety/Efficacy Study NCT00524420
rTMS; Sham rTMS Fibromyalgia; Chronic Pain; Depression
Rec 44 Adt
F-only
Feb-08 Sep-10 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Uni. of Washington
http://ClinicalTrials.gov/show/NCT00524420
External peripheral neuromodulation for the relief of chronic pain RCT ISRCTN07743794
External peripheral neuromodulation; Sham
Chronic pain Active 40 Adt Sen
Aug-09 Aug-10 Guy‟s and St Thomas‟ NHS Foundation Trust, UK
http://www.controlled-trials.com/ISRCTN07743794
Does the Spinal Modulation Neurostimulator System provide safe and efficacious pain relief in people with chronic pain? Single Group Assignment ACTRN12609000739213
Spinal modulation Neurostimulator System
Chronic pain Comp 10 Adt Sen
Sep-09 > Sep-09
Five Corners Pty Ltd, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=308358
Prometra Implantable Programmable Pump Single Group Assignment, Safety/Efficacy Study NCT00817596
Infusion Pump (Prometra)
Intractable Pain Active, NR
110 Adt Sen
Jan-07 Apr-09 InSet Technologies http://ClinicalTrials.gov/show/NCT00817596
Prometra's Utilization in Mitigating Pain II NCT00866164
Prometra Programmable Pump
Intractable Pain; Back Pain; Leg Pain; Arm Pain; Trunk Pain
Expand Adt Sen
N/K ? Mar-09
InSet Technologies http://ClinicalTrials.gov/show/NCT00866164
Autonomic Function Testing and Spinal Cord Stimulation in Chronic Visceral Pain Phase IV: Non-randomized (placebo) NCT00678717
Medtronic or ANS spinal cord stimulator; Sham
Chronic Pain Rec 60 Adt Feb-08 Feb-09 Vanderbilt Uni. http://ClinicalTrials.gov/show/NCT00678717
123
The Use of Transcutaneous Electrical Nerve Stimulation (TENS) for Chronic Pain of Predominantly Peripheral Neuropathic Origin RCT (placebo), Efficacy Study NCT00716326
TENS + exercise; Placebo TENS + exercise
Neuropathic Pain Comp 115 Adt Sen
Jan-07 Dec-08 Norwegian Fund for Postgraduate Training in Physiotherapy
http://ClinicalTrials.gov/show/NCT00716326
SynchroMed II Post-Approval Study Phase IV: Observational: Prospective, Cohort Study NCT00773019
SynchroMed® II Programmable Drug Infusion Pump
Severe Spasticity; Chronic Pain
Comp 84 Adt Sen
Nov-04 Nov-08 MedtronicNeuro http://ClinicalTrials.gov/show/NCT00773019
Placebo Transcutaneous Electrical Nerve Stimulation (TENS) NCT00750321
Active TENS; Inactive Placebo; Transient Placebo
TENS Comp Adt N/K ? Sep-08
Uni. of Iowa http://ClinicalTrials.gov/show/NCT00750321
Drugs including biologics
Long-Term Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Pain Phase III: Single Group Assignment, Safety Study NCT01115569
Hydrocodone bitartrate
Chronic Pain Not yet Rec
600 Adt Sen
May-10
Dec-11 Zogenix, Inc. http://ClinicalTrials.gov/show/NCT01115569
QTc and Perceived Sleep Follow up Among Chronic Pain Patients With Opiate Medication Single Group Assignment NCT00999440
Methadone Chronic Pain Not yet Rec
100 Adt Sen
Jan-10 Dec-11 Tel-Aviv Sourasky Medical Center
http://ClinicalTrials.gov/show/NCT00999440
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone Single Group Assignment, Safety Study NCT00945919
Oxymorphone ER Chronic Nociceptive Pain; Neuropathic Pain; Non-cancer Pain
Rec 12 Adt Sen
Jul-09 May-11 Mount Sinai School of Medicine; Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00945919
Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain Phase II/III: RCT (placebo), Safety/Efficacy Study NCT00153192
Marinol (dronabinol) Chronic Pain Active, NR
30 Child Adt Sen
Apr-01 Apr-11 Brigham and Women's Hospital; Solvay Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00153192
124
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug (NSAID) Treatment Phase III: Single Group Assignment, Safety Study NCT00984815
HZT-501 OA; RA; Chronic Low Back Pain; Chronic Regional Pain Syndrome; Chronic Soft Tissue Pain
Rec 100 Adt Sen
Sep-09 Mar-11 Horizon Therapeutics, Inc.
http://ClinicalTrials.gov/show/NCT00984815
Safety Study to Assess Opiate Withdrawal Signs and Symptoms in Opioid Dependent Patients Phase IV: Randomized, Crossover Assignment, Pharmacodynamics Study NCT01100437
EMBEDA™ (morphine sulfate/ naltrexone hydrochloride) whole; EMBEDA™ crushed
Chronic Pain Rec 80 Adt Sen
Apr-10 Dec-10 Alpharma Pharmaceuticals LLC, a subsidiary of King Pharmaceuticals, Inc.
http://ClinicalTrials.gov/show/NCT01100437
A Long-Term Study of JNS020QD (Fentanyl) in Chronic Pain Patients Phase III: Single Group Assignment, Safety/Efficacy Study NCT00788372
Fentanyl Pain Active, NR
138 Adt Sen
Sep-08 Dec-10 Janssen Pharmaceutical K.K.
http://ClinicalTrials.gov/show/NCT00788372
Effect of Ketamine on Opioid-Induced Hyperalgesia Randomized, Parallel Assignment, Efficacy Study NCT00833755
Ketamine Pain; Chronic Pain; Hyperalgesia
Rec 136 Adt Sep-08 Dec-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00833755
Hormone Function in Men Treated for Pain With Opioids or Placebo Phase IV: RCT (placebo), Safety Study NCT00737737
MS Contin Chronic Pain; OA Rec 18 Adt
M-only
Aug-08 Dec-10 National Institute of Nursing Research (NINR)
http://ClinicalTrials.gov/show/NCT00737737
Modulation of Central Hypersensitivity in Musculoskeletal Pain by Intravenous Tropisetron Phase II: Randomized, Crossover Assignment, Efficacy Study NCT00889499
Tropisetron 2mg; Tropisetron 5mg; Placebo
Pain; Chronic Disease
Not yet Rec
30 Adt Sen
Apr-09 Sep-10 Uni. Hospital Inselspital, Berne
http://ClinicalTrials.gov/show/NCT00889499
A population study in patients who do not respond to oral codeine ISRCTN16874724
Oral Codeine Chronic pain Active 150 Adt Sen
Jan-09 Sep-10 Leeds Teaching Hospitals NHS Trust, UK
http://www.controlled-trials.com/ISRCTN16874724
125
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Phase IV: RCT (active), Efficacy Study NCT00879996
Methadone; Buprenorphine/naloxone
Opiate Addiction Rec 60 Adt Sen
Feb-09 Aug-10 State Uni. of New York at Buffalo; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
http://ClinicalTrials.gov/show/NCT00879996
The Effect of Intravenous Lidocaine on Allodynia Single Group Assignment (dose comparison), Efficacy Study NCT00659633
Lidocaine Pain Rec 10 Adt Sen
Dec-08 Jul-10 Uni. of Alabama at Birmingham; American Society of Regional Anesthesia
http://ClinicalTrials.gov/show/NCT00659633
A Safety and Effectiveness Study of Intraspinal MDT2004 for the Treatment of Chronic Pain Phase II: RCT (placebo), Safety/Efficacy Study NCT00414466
Intraspinal MDT2004
Chronic Intractable Pain
Active, NR
144 Adt Sen
Dec-06 Jun-10 MedtronicNeuro http://ClinicalTrials.gov/show/NCT00414466
A Study To Observe The Performance Of A Tablet Form Of PF-04531083 As Evidenced By The Concentration Of PF-04531083 In The Blood With Time Following Oral Administration To Healthy Volunteers. Phase I: Non-randomized, Parallel Assignment, Pharmacokinetics Study NCT01119235
PF-04531083 Chronic Pain Not yet Rec
24 Adt May-10
Jun-10 Pfizer http://ClinicalTrials.gov/show/NCT01119235
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic Phase III: Single Group Assignment, Safety/Efficacy Study NCT00983073
Tapentadol Chronic Pain; OA Rec 180 Adt Sen
Sep-09 Jun-10 Grünenthal GmbH http://ClinicalTrials.gov/show/NCT00983073
126
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability Phase III: Single Group Assignment, Safety/Efficacy Study NCT00982280
Tapentadol Chronic Pain; OA Rec 180 Adt Sen
Sep-09 Jun-10 Grünenthal GmbH http://ClinicalTrials.gov/show/NCT00982280
Effect of Extended-Release Oxymorphone Taking With or Without Food on Cognitive Functioning Phase IV: Randomized, Crossover Assignment, Pharmacodynamics Study NCT00930943
Oxymorphone ER (Opana ER)
Chronic Non-Malignant Pain
Rec 32 Adt May-09
May-10 MedVadis Research Corporation
http://ClinicalTrials.gov/show/NCT00930943
To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications Phase I: Randomized, Parallel Assignemtn, Pharmacokinetics Study NCT01103739
PF-04531083; Simvastatin
Chronic Pain Rec 24 Adt Mar-10 Apr-10 Pfizer http://ClinicalTrials.gov/show/NCT01103739
Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected Phase I: Non-randomized, Parallel Assignment, Efficacy Study NCT01030640
Tanezumab; Placebo
OA Pain; Chronic Low Back Pain; Pain Due to Interstitial Cystitis
Active, NR
28 Adt Jan-10 Apr-10 Pfizer http://ClinicalTrials.gov/show/NCT01030640
The Preemptive Analgetic Potency of Low Dose S-Ketamine Phase III RCT (dose comparison), Safety/Efficacy Study NCT01022840
S-Ketamine; Placebo
Pain Rec 60 Adt Sen
Feb-09 Mar-10 Medical Uni. of Graz
http://ClinicalTrials.gov/show/NCT01022840
127
Efficacy and Safety of Fentanyl Buccal Tablets Compared With Immediate Release Oxycodone for the Management of Breakthrough Pain in Opioid Tolerant Patients With Chronic Pain Phase III: RCT (active), Safety/Efficacy Study NCT00813488
Fentanyl Buccal Tablet; Immediate-Release Oxycodone
Chronic Pain Comp 213 Adt Sen
Dec-08 Jan-10 Cephalon http://ClinicalTrials.gov/show/NCT00813488
Effect of IV Lidocaine Infusions on Pain Single Group Assignment, Efficacy Study NCT00725504
Intravenous lidocaine
Pain Rec 100 Adt Sen
Sep-08 Dec-09 Stanford Uni. http://ClinicalTrials.gov/show/NCT00725504
Effects of opioid analgesics on driving ability of pain patients Non-randomized, Parallel Assignment, Efficacy Study DRKS00000262
Opioid analgesics Pain Comp 60 Adt Nov-09 > Nov-09
Bundesanstalt für Straβenwesen
http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000262
A study to evaluate whether increased codeine levels are seen when both codeine and ketamine are given in small doses to well volunteers. Single Group Assignment, Pharmacokinetics Study ACTRN12610000283077
Ketamine + Codeine
Severe chronic pain
Comp 10 Adt Nov-09 > Nov-09
Flinders University, Australia
http://www.anzctr.org.au/trial_view.aspx?ID=320900
Randomized, Double-Blind Cross-Over Trial Of Buprenorphine and Low-Dose Naloxone Versus Buprenorphine Randomized, Crossover Assignment, Safety/Efficacy Study NCT00679458
Buprenorphine and low-dose naloxone; Buprenorphine alone
Pain, Chronic Comp 12 Adt Sen
Sep-08 Nov-09 University of California, Los Angeles; Reckitt Benckiser Pharmaceuticals, Inc
http://ClinicalTrials.gov/show/NCT00679458
A Verification Study of a Long-term Use of JNS013 in Patients With Chronic Pain Phase III: Single Group Assignment, Safety/Efficacy Study NCT00736957
JNS013 Pain Comp 190 Adt Sen
Apr-08 Oct-09 Janssen Pharmaceutical K.K.
http://ClinicalTrials.gov/show/NCT00736957
128
AZD2066 Cocktail Study Phase I Single Group Assignment, Bio-availability Study NCT00930306
AZD2066; Caffeine; Tolbutamide; Omeprazole Tablet, 20 mg; Midazolam Tablet, 7.5 mg
Chronic Pain Comp 15 Adt Jun-09 Sep-09 AstraZeneca http://ClinicalTrials.gov/show/NCT00930306
Sublingual Buprenorphine for Chronic Pain Phase II: Single Group Assignment, Efficacy Study NCT00612287
Buprenorphine Chronic Pain Not yet Rec
40 Adt Sen
Apr-09 Aug-09 National Institute on Drug Abuse (NIDA); Beth Israel Medical Center
http://ClinicalTrials.gov/show/NCT00612287
A Multiple Dose Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04457845 in Healthy Volunteers Phase I: Randomized, Parallel Assignment, Safety Study NCT00836082
PF-04457845, FAAH inhibitor
Acute Pain; Chronic Pain
Comp 41 Adt Feb-09 Jul-09 Pfizer http://ClinicalTrials.gov/show/NCT00836082
An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain Phase III: Single Group Assignment, Safety/Efficacy Study NCT00487435
CG5503 Pain; OA; Low Back Pain
Comp 1166 Adt Sen
Feb-07 Jun-09 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00487435
Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-Malignant Pain Phase IV: RCT (placebo), Efficacy Study NCT00547885
Dihydrocodeine Pain Rec 60 Adt Sen
Oct-07 ? May-09
Norwegian Uni. of Science and Technology
http://ClinicalTrials.gov/show/NCT00547885
A Double-Blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic OA Pain Phase III: RCT (placebo), Safety/Efficacy Study NCT00631319
OROS Hydromorphone
Chronic Pain Active, NR
400 Adt Sen
Feb-08 Apr-09 Neuromed Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00631319
129
Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain Phase III: RCT (active) NCT00463047
Fentanyl Buccal Tablets; Immediate-Release Oxycodone
Chronic Pain Comp 324 Adt Sen
Jun-07 Feb-09 Cephalon http://ClinicalTrials.gov/show/NCT00463047
A Confirmatory Study of JNS013 in Patients With Chronic Pain Phase III: Randomized, Parallel Assignment, Efficacy Study NCT00736853
Tramadol Hydrochloride + Acetaminophen; Tramadol Hydrochloride + Acetaminophen
Pain Comp 321 Adt Sen
May-08
Jan-09 Janssen Pharmaceutical K.K.
http://ClinicalTrials.gov/show/NCT00736853
Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza Phase IV: Single Group Assignment, Safety/Efficacy Study NCT00640042
Morphine sulfate extended release capsules
Pain Comp 1570 Adt Sen
Mar-08 Dec-08 King Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00640042
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1386 Phase I: Randomized, Parallel Assignment, Safety Study NCT00690079
AZD1386; Placebo Chronic Pain Comp 69 Adt Sen
Feb-08 Nov-08 AstraZeneca http://ClinicalTrials.gov/show/NCT00690079
Buprenorphine as a Treatment in Opiate Dependent Pain Patients Phase IV: RCT (active), Efficacy Study NCT00552578
Buprenorphine/ Naloxone
Opiate Addiction; Refractory Pain
Term 12 Adt Sen
Oct-07 Oct-08 State Uni. of New York at Buffalo
http://ClinicalTrials.gov/show/NCT00552578
Double-Blind Follow-on Safety Study of HZT-501 in Subjects Who Have Completed Participation in HZ-CA-301 or HZ-CA-303 Phase III: RCT (active), Safety Study NCT00613106
Ibuprofen/ Famotidine; ibuprofen
OA; RA; Chronic Low Back Pain; Chronic Regional Pain Syndrome; Chronic Soft Tissue Pain
Comp 300 Adt Sen
Sep-07 Oct-08 Horizon Therapeutics, Inc.
http://ClinicalTrials.gov/show/NCT00613106
130
AZD1386 Japanese Multiple Ascending Dosing Study Phase I: Randomized, Parallel Assignment, Safety Study|Primary Purpose: Treatment NCT00736658
AZD1386; Placebo Chronic Pain Comp 32 Adt Sen
Jun-08 Sep-08 AstraZeneca http://ClinicalTrials.gov/show/NCT00736658
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation) Single Group Assignment NCT00580294
Oxymorphone IV Pain Comp 12 Adt Sen
Nov-07 Aug-08 Mount Sinai School of Medicine; Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00580294
Study of D-Methadone in Patients With Chronic Pain Phase I/II: Randomized, Crossover Assignment, Safety/Efficacy Study NCT00588640
D-Methadone; Placebo
Pain including pain associated with
10
Comp 64 Adt Sen
Oct-04 Jul-08 Memorial Sloan-Kettering Cancer Center
http://ClinicalTrials.gov/show/NCT00588640
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain Phase III: Randomized, Parallel Assignment, Safety Study NCT00361504
Tapentadol (CG5503) PR; Oxycodone CR;
OA, Hip; OA, Knee; Lower Back Pain; Pain
Comp 1122 Adt Sen
Oct-06 Jul-08 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Grünenthal GmbH
http://ClinicalTrials.gov/show/NCT00361504
Open Label, Safety Study of EN3270 in Patients With Moderate to Severe Non-Malignant, Chronic Pain Phase II: RCT (dose comparison), Safety Study NCT00485225
Transdermal patch (EN3270)
Chronic, Non Malignant Pain
Comp 77 Adt Jun-07 Jul-08 Endo Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00485225
Efficacy of Matrifen in Patients Older Than 18 Years With Severe, Chronic Pain Observational: Prospective, Case-only Study NCT00556270
Matrifen Severe, Chronic Pain
Comp 3000 Adt Sen
Nov-07 May-08 Nycomed http://ClinicalTrials.gov/show/NCT00556270
10 Bladder Cancer; Breast Cancer; CNS Cancer; Colon Cancer; Esophageal Cancer; Pancreatic Cancer; Prostate Cancer; Uterine Cancer; Head and Neck Cancer; Eye Cancer; Otorhinolaryngologic Neoplasms
131
Paracetamol and Glutathion Phase I: Single Group Assignment, Pharmacodynamics Study NCT01116596
Paracetamol Chronic Pain; Elderly
Comp 18 Sen Feb-07 May-08 Uni. Hospital, Clermont-Ferrand
http://ClinicalTrials.gov/show/NCT01116596
Other including CAM
Stepped Care to Optimize Pain Care Effectiveness Phase III: Randomized, Efficacy Study NCT00926588
Stepped Care to Optimize Pain Care Effectiveness
Pain Rec 250 Adt Oct-09 Sep-13 Department of Veterans Affairs
http://ClinicalTrials.gov/show/NCT00926588
Collaborative care: integrated antidepressant and psychotherapeutic treatment of concomitant pain and depressive disorder in primary care. RCT (active) NTR1089
Combined care (integrated antidepressant + psycho-therapeutic care)
Pain; Depression Active 219 N/K Sep-07 Feb-13 Trimbos-institute http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1089
Evaluating the Effect of Acupuncture on Pain Relief Using Quantitative Sensory Testing (QST) RCT (placebo), Efficacy Study NCT01094782
Acupuncture; Sham Acupuncture; Neither
Pain Rec 150 Adt Jan-10 Dec-11 Massachusetts General Hospital; National Institutes of Health (NIH)
http://ClinicalTrials.gov/show/NCT01094782
Study of practice pharmacist-led management of long-term pain RCT ISRCTN06131530
Pharmacist review; Pharmacist prescribing; Standard GP care
Chronic Pain Active 232 Adt Sen
Jan-10 Nov-10 University of Aberdeen
http://www.controlled-trials.com/ISRCTN06131530
Integrative Medicine Consultation for Patients With Pain or Fatigue Randomized, Parallel Assignment NCT01058265
Integrative; Standard
Pain; Fatigue Rec 50 Adt Sen
Oct-09 Oct-10 Mayo Clinic http://ClinicalTrials.gov/show/NCT01058265
The Application of Performance Improvement Principles to the Patient Throughput Process in an Adult Outpatient Pain Treatment Clinic Observational: Prospective, Case-only Study NCT00888420
Performance Improvement Measures
Chronic Pain Rec 1200 Adt Sen
Feb-08 Jul-10 Uni. of Alabama at Birmingham
http://ClinicalTrials.gov/show/NCT00888420
132
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients Retrospective NCT01052155
Urine Drug Testing Chronic Pain Invite 1000 Adt Sen
Feb-10 Jun-10 Pain Management Center of Paducah
http://ClinicalTrials.gov/show/NCT01052155
Effect of electroacupuncture on opioid consumption by patients with chronic pain RCT (placebo), Efficacy Study ACTRN12609000676213
Electro-acupuncture
Chronic pain Comp 315 Adt Sen
Jul-09 > Oct-09
National Ageing Research Institute; Caulfield Pain Management and Research Centre; Royal Melbourne Hospital
http://www.anzctr.org.au/trial_view.aspx?ID=308008
Chronic Pain Care Network Single Group Assignment NCT00909493
Network Access Chronic Pain Active, NR
20 Adt Sen
Jun-08 May-09 Capital District Health Authority, Canada; Canadian Anesthesiologists' Society
http://ClinicalTrials.gov/show/NCT00909493
Acceptability of an Acupuncture Intervention in Painful Elderly Single Group Assignment NCT01043692
Acupuncture Chronic Pain Comp 60 Adt Sen
Oct-07 Dec-08 Assistance Publique - Hôpitaux de Paris; Fondation de France
http://ClinicalTrials.gov/show/NCT01043692
Is triage an effective way of initiating early intervention for patients with a chronic musuloskeletal condition on a hospital waiting list? RCT (active), Efficacy Study ACTRN12608000316303
Physiotherapy intervention; Waiting list
Chronic MSK pain
Comp 75 Child Adt Sen
Jun-08 > Jun-08
University of Canberra
http://www.anzctr.org.au/trial_view.aspx?ID=82652
Miscellaneous observational studies
Evaluation of Pain Location, Pain Quality and Pain Patterns in Subjects With Chronic Pain Prospective, Cross-sectional Study NCT00284245
Pain; Chronic Disease
Rec 10000
Adt Sen
Jun-04 ? Taylor MicroTechnology
http://ClinicalTrials.gov/show/NCT00284245
Observatory on Elderly Patients “Les S.AGES" Prospective, Cohort Study NCT01065909
Diabetes Mellitus, Type 2; Chronic Pain; Atrial Fibrillation
Rec 5800 Adt Sen
Apr-09 Oct-13 Sanofi-Aventis http://ClinicalTrials.gov/show/NCT01065909
133
Endogenous pain control mechanisms in patients with chronic arthritic pain UKCRN ID 4786
Chronic arthritic pain
Active 240 N/K N/K Aug-11 Hope Hospital, Manchester
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4786
Pain Responses in Patients on Long-Term Opioid Therapy for Chronic Pain Cross-sectional, Case-Control NCT00656942
Chronic Pain Rec 164 Adt Jul-06 Dec-10 Massachusetts General Hospital
http://ClinicalTrials.gov/show/NCT00656942
Use of Driving Tests to Evaluate Patient Performance on Oral Opioids Phase III: Cross-sectional, Case-Control NCT00659035
Chronic Pain Rec 450 Adt Sen
Apr-08 Dec-10 Rush Uni. Medical Center
http://ClinicalTrials.gov/show/NCT00659035
Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine Prospective, Cohort Study NCT00740233
Gastro-intestinal Diseases; Chronic Pain; Stress; Anxiety; Depression
Rec 1000 Adt Jun-08 Dec-10 Uni. of California, Los Angeles; National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT00740233
Preventing pain from interfering with later life: an action oriented qualitative study UKCRN ID 7916
Chronic pain Active 60 N/K N/K Oct-10 Keele University http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=7916
Somaethesia sensation and the perception of pain in rheumatic disease UKCRN ID 6276
Chronic pain; MSK conditions
Comp 174 N/K N/K Aug-10 Bath Royal National Hospital for Rheumatic Disease
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6276
Susceptibility to Chronic Post-Traumatic Extremity Pain Prospective, Case Control Study NCT00672711
Chronic Pain Rec 250 Adt Sen
Apr-08 Jul-10 William Beaumont Hospitals; Beaumont Foundation of America; Oakland Uni.
http://ClinicalTrials.gov/show/NCT00672711
A Prevalence Study of Chronic Widespread Pain (CWP) Among Patients With Rheumatoid Arthritis (RA) and Control Population in Tallinn and Harjumaa County Cross-sectional, Case-Control NCT00721318
Chronic Widespread Pain
Active, NR
6000 Child Adt Sen
May-08
May-10 Estonian Society for Rheumatology
http://ClinicalTrials.gov/show/NCT00721318
134
The Prevalence of Metabolic Syndrome in Patients Suffering From Chronic Pain Prospective, Cohort Study NCT00885261
Pain and Metabolic Syndrome
Rec 100 Adt Sen
May-09
Apr-10 Tel-Aviv Sourasky Medical Center
http://ClinicalTrials.gov/show/NCT00885261
Evaluation of Assessments of Motor Performance, Physical Impairments and Functional Abilities Prospective NCT00747955
Healthy Not yet Rec
500 Child Adt Sen
Aug-08 ? Apr-10
National Institutes of Health Clinical Center (CC)
http://ClinicalTrials.gov/show/NCT00747955
Association Between Hypermobility and Chronic Musculoskeletal Pain Cross-sectional, Case-only NCT01032863
Hypermobility, Joint; Arthralgia; Myofascial Pain Syndromes; Fibromyalgia; Pain Disorder
Comp 112 Adt Dec-09 Mar-10 Amrita Institute of Medical Sciences & Research Center
http://ClinicalTrials.gov/show/NCT01032863
Blood Sample Donations to Study the Role of Genes in Pain NCT00341367
Pain Comp 320 Child Adt Sen
Dec-02 Mar-10 National Institute on Alcohol Abuse and Alcoholism (NIAAA)
http://ClinicalTrials.gov/show/NCT00341367
Pain Study to See if Ultram ER Will Provide Relief to Subjects Whose Pain is Not Well Controlled by Narcotics Prospective, Case-Control Study NCT00505531
Chronic Pain Active, NR
93 Adt Jun-07 Dec-09 Massachusetts General Hospital; Ortho-McNeil, Inc.
http://ClinicalTrials.gov/show/NCT00505531
How chronic pain affects posture and movement: can motion capture technology enable us to separate the autonomic component of pain from communicative intent and other affective states? UKCRN ID 6456
Chronic Pain Active 50 N/K N/K Aug-09 University College London
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6456
Efficacy of Matrifen in Patients Older Than 18 Years With Severe, Chronic Pain Including Quality of Life Questionnaire Prospective, Case-only Study NCT00699335
Severe, Chronic Pain
Comp 7000 Adt Sen
Jun-08 May-09 Nycomed http://ClinicalTrials.gov/show/NCT00699335
135
Exploring justice issues in chronic pain: sufferer and partner perspectives Intervention? UKCRN ID 4547
Chronic pain Comp 130 N/K N/K Mar-09 Caledonian University Glasgow
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4547
Augmented Cerebral Pain Processing in Chronic, Unexplained Pain: a fMRI Study Cross-sectional NCT00463177
Pain Comp 24 Adt Sen
Mar-07 Jun-08 UMC Utrecht; K.F. Hein Stichting; Fonds Psychische Gezondheid
http://ClinicalTrials.gov/show/NCT00463177
A11: PAIN
Title Phases: study design (control) NCT ID
Interventions Conditions Recruit n Age Grp
Start Date
End Date
Sponsors URL
Behavioural, education & exercise including physiotherapy
The Effects of Well-being Interventions on Affect, Attention, Sleep, Social Stress and Pain Regulation Randomized, Factorial Assignment NCT01057368
Day of intensive meditation practice; Mindfulness Based Stress Reduction (MBSR); Health Enhancement Program (HEP)
Health; Mental Health
Rec 150 Adt Nov-09 Sep-12 University of Wisconsin, Madison; National Center for Complementary and Alternative Medicine (NCCAM)
http://ClinicalTrials.gov/show/NCT01057368
Improvement of a Physically Active Lifestyle RCT (active), Efficacy Study NCT00979719
Interactive, computerized expert system (tailors treatment individual needs); interactive computerized standard program (proven to be effective); answer questions only
Pain; Osteoarthritis; Rheumatoid Arthritis; Heart Diseases; Diabetes Mellitus, Type 2; Behavior; Motivation
Rec 1000 Adt Sen
Oct-09 Mar-12 Freie Universitat Berlin; Deutsche Rentenversiche-rung Bund (DRV; German Retirement Insurance)
http://ClinicalTrials.gov/show/NCT00979719
136
Long Term and Clinical Impact of the Lifestyle Management for Arthritis Programme (LMAP) for People with Inflammatory Arthritis Cohort Study UKCRN ID 4572
Lifestyle Management for Arthritis Programme; information-based programme
Inflammatory arthritis
Active 293 Adt Sen
N/K Feb-11 University of Salford, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4572
Help Arthritis With Exercise in West Virginia Phase III: RCT (placebo), Safety/Efficacy Study NCT00526201
12-weeks EnhanceFitness; Control
Arthritis Active, NR
375 Adt Sen
May-08
Dec-10 Centers for Disease Control and Prevention; West Virginia University
http://ClinicalTrials.gov/show/NCT00526201
Effect of Patient Education in Rheumatic Diseases Randomized, Parallel Assignment, Efficacy Study NCT00623922
Patient education with individual nurse consultations
Polyarthritis Active, NR
140 Adt Sen
Feb-08 Feb-10 Norwegian University of Science and Technology; The Research Council of Norway
http://ClinicalTrials.gov/show/NCT00623922
Evaluation of Walk With Ease in Arthritis Phase III: Parallel Assignment (placebo), Safety/Efficacy Study NCT00526435
Walk with Ease - Group; Walk with Ease - Self; Control
Arthritis Not yet Rec
657 Adt Sen
Oct-07 Oct-09 Centers for Disease Control and Prevention; University of North Carolina
http://ClinicalTrials.gov/show/NCT00526435
Pain and Stress Management for People With Rheumatoid Arthritis Phase II: RCT (active), Efficacy Study NCT00088764
Coping skills training; Written emotional disclosure; Arthritis education; Health behavior writing
Rheumatoid Arthritis
Active, NR
280 Adt Sen
Feb-05 Jun-09 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00088764
Coping Skills Training for Early Rheumatoid Arthritis RCT (active), Efficacy Study NCT00056394
Comprehensive Coping Skills Training; Arthritis Education Sessions; Standard Care
Rheumatoid Arthritis
Comp 225 Adt Sen
Feb-03 Apr-09 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00056394
Exercise Adherence Among Older Adults With Osteoarthritis RCT (active), Efficacy Study NCT00421681
Fit and Strong! Exercise Program
Osteoarthritis Active, NR
600 Adt Sen
Oct-03 Sep-08 National Institute on Aging (NIA)
http://ClinicalTrials.gov/show/NCT00421681
137
RAHelp.Org: An Online Self Management Program for Adults With Rheumatoid Arthritis RCT (placebo), Efficacy Study NCT00283855
Online self-management program
Rheumatoid Arthritis
Comp 200 Adt Sen
Oct-03 Sep-08 University of Missouri-Columbia; U.S. Department of Education
http://ClinicalTrials.gov/show/NCT00283855
Device
Applications of Realtime Functional Magnetic Resonance Imaging (fMRI ) Single Group Assignment, Efficacy Study NCT01111617
Real-time fMRI feedback
Pain Not yet Rec
400 Adt May-10
Feb-12 Stanford University http://ClinicalTrials.gov/show/NCT01111617
The Effect of Alternative Keyboards on Discomfort and Typing Kinematics RCT (active), Safety/Efficacy Study NCT00801983
Alternative Keyboard
Pain Not yet Rec
70 Adt Jan-09 Mar-11 University of Pittsburgh; National Institute for Occupational Safety and Health (NIOSH/CDC)
http://ClinicalTrials.gov/show/NCT00801983
Study to Evaluate ATP-induced Pain and ATP-induced Dermal Vasodilation by Iontophoresis Phase I: RCT (placebo), Efficacy Study NCT00917696
Iontophoresis and Laser Doppler with ATP; Iontophoresis and Laser Doppler with Saline
Osteoarthritis Pain
Rec 24 Adt
M-only
Oct-09 Jun-10 Merck http://ClinicalTrials.gov/show/NCT00917696
Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception RCT (placebo) NCT01030133
Transcranial Magnetic Stimulation
Pain Rec 100 Adt Sen
Oct-09 Feb-10 Medical University of South Carolina
http://ClinicalTrials.gov/show/NCT01030133
Pain Monitoring Using Plurality of Non-invasive Physiological Measurement Single Group Assignment NCT00914173
Scanlaf Circulator and water bath; Medoc TSA 2000
Pain Comp 100 Adt Nov-08 Oct-09 Medasense Biometrics Ltd
http://ClinicalTrials.gov/show/NCT00914173
Effect of Electroacupuncture on Pain Threshold Phase I: Randomized, Parallel Assignment, Efficacy Study NCT00802165
Electro-acupuncture; Sham electro-acupuncture
Pain Rec 40 Child Adt Sen
Dec-08 Apr-09 Logan College of Chiropractic
http://ClinicalTrials.gov/show/NCT00802165
138
Far Infrared Radiation Treatment for Osteoarthritis Phase I: Single Group Assignment NCT00573352
Far Infrared Radiation
Osteoarthritis Active, NR
2 Child Adt Sen
Sep-06 Dec-08 GAAD Medical Research Institute Inc.
http://ClinicalTrials.gov/show/NCT00573352
Management of Acute Pain in the Emergency Department Prospective, Cohort Study NCT00470652
Computer-assisted decision support
Pain Comp 631 Child Adt Sen
May-07
Sep-08 Centre Hospitalier Universitaire Vaudois; Societe Française de Medecine d'urgence
http://ClinicalTrials.gov/show/NCT00470652
Dietry Supplement
Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis Phase IV: Randomized, Parallel Assignment, Efficacy Study NCT01073982
Dietary Supplement: tart cultivar Montmorency cherry juice
Pain; Inflammation
Not yet Rec
20 Adt Sen
Feb-10 Aug-10 Oregon Health and Science University; Cherry Research Committee
http://ClinicalTrials.gov/show/NCT01073982
Effectiveness of Glucosamine + Chondroitin in Osteoarthrosis Phase III: RCT (active), Safety/Efficacy Study NCT00860873
EMS Chondroitin Sulfate + Glucosamine Sulfate (Oral powder); EMS Chondroitin Sulfate 1200mg + Glucosamine Sulfate 1500mg (hard capsules); Zodiac Chondroitin Sulfate 1200mg + Glucosamine Sulfate 1500mg (Oral powder); Zodiac Chondroitin Sulfate 1200mg + Glucosamine Sulfate 1500mg (hard capsules)
Osteoarthrosis Not yet Rec
280 Adt Sen
May-09
May-10 L.A.L Clinica Pesquisa e Desenvolvimento Ltda.
http://ClinicalTrials.gov/show/NCT00860873
139
Marine Oils and Arthritis Randomized, Parallel Assignment NCT00805116
Whale blubber oil; Cod liver oil
Rheumatoid Arthritis
Term 80 Adt Sen
Dec-08 Oct-09 National Institute of Nutrition and Seafood Research, Norway
http://ClinicalTrials.gov/show/NCT00805116
Drugs including biologics
Subjective Analgesic Effects of Naloxone and Virtual Reality RCT (placebo), Efficacy Study NCT01105871
Naloxone; Placebo Pain Not yet Rec
50 Adt Aug-10 Jun-14 University of Washington
http://ClinicalTrials.gov/show/NCT01105871
Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Phase IV: Randomized, Parallel Assignment, Safety Study NCT00346216
Celecoxib; Ibuprofen; Naproxen
Arthritis, Rheumatoid; Osteoarthritis; Pain
Rec 20000 Adt Sen
Oct-06 Feb-13 Pfizer; The Cleveland Clinic
http://ClinicalTrials.gov/show/NCT00346216
An Efficacy and Safety Study of Intravenous Golimumab in Patients With Active Rheumatoid Arthritis (RA) Despite Treatment With Methotrexate, Non Steroidal Pain Medications and/or Corticosteroids Phase III: Randomized, Cross-over Assignment, Safety/Efficacy Study NCT00973479
Golimumab; Placebo
Arthritis, Rheumatoid
Rec 564 Adt Sen
N/K Dec-12 Centocor, Inc.; Schering-Plough
http://ClinicalTrials.gov/show/NCT00973479
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain Phase II: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00973141
JNJ-42160443; Placebo
Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain; Arthralgia; Joint Pain
Active, NR
420 Adt Sen
N/K Sep-12 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
http://ClinicalTrials.gov/show/NCT00973141
Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers Phase III: Randomized, Crossover Assignment, Pharmacokinetics/ Dynamics Study NCT01011036
Clobazam; Clonazepam; Tolterodine
Pain Rec 16 Adt
M-only
Dec-09 Nov-11 University Hospital Inselspital, Berne
http://ClinicalTrials.gov/show/NCT01011036
140
Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Phase IV: Randomized, Crossover Assignment, Efficacy Study NCT01067430
Etoricoxib; Diclofenac
Rheumatoid Arthritis
Not yet Rec
20 Adt Sen
Apr-10 Apr-11 Northumbria Healthcare NHS Foundation Trust
http://ClinicalTrials.gov/show/NCT01067430
Role of Methadone As Co-Opioid Analgesic Phase II: RCT (active), Safety/Efficacy Study NCT00558870
Morphine; Methadone
Pain Rec 60 Adt Sen
Nov-07 Feb-11 M.D. Anderson Cancer Center
http://ClinicalTrials.gov/show/NCT00558870
The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers Single Group Assignment (dose comparison), Efficacy Study NCT00657358
Lidocaine Pain Rec 10 Adt Sen
Apr-08 Dec-10 University of Alabama at Birmingham; American Society of Regional Anesthesia
http://ClinicalTrials.gov/show/NCT00657358
The effect of ketamine and methadon on healthy volunteers with special focus on painscore, sedation, ventilatory depression and change of pupil diameter. RCT (placebo) NTR2039
Ketamine; Methadone intravenous
Analgesia N/K 48 Adt Jan-10 Sep-10 Leiden University Medical Centre
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2039
Evaluation of Propranolol's Effect on Pain and Inflammation. Randomized, Crossover Assignment, Efficacy Study NCT01094574
Propranolol Pain Measurement
Rec 10 Child Adt Sen
Jan-10 Aug-10 Stanford University http://ClinicalTrials.gov/show/NCT01094574
Safety, Tolerability and Efficacy Study With a Fixed-Dose Combination (FDC) Ketoprofen Plus Omeprazole Phase III: Single Group Assignment, Safety/Efficacy Study NCT00971581
FDC Ketoprofen + Omeprazole
Pain Rec 50 Adt Sen
Aug-09 May-10 Sanofi-Aventis http://ClinicalTrials.gov/show/NCT00971581
141
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model Phase I: Randomized, Crossover Assignment, Pharmacodynamics Study NCT01006304
JNJ-39439335, Placebo
Pain Rec 12 Adt
M-only
Jun-09 May-10 Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
http://ClinicalTrials.gov/show/NCT01006304
Effect of Spinal Ketorolac After Acute Opioid Exposure Phase II: Randomized, Parallel Assignment, Efficacy Study NCT00693160
Ketorolac; Placebo; Remifentanil
Healthy Rec 50 Adt Dec-07 Apr-10 Wake Forest University; National Institute of General Medical Sciences (NIGMS)
http://ClinicalTrials.gov/show/NCT00693160
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training RCT (placebo) NCT01083901
Acetaminophen; Ibuprofen; Behavioral: high intensity progressive resistance exercise training; placebo
Sarcopenia; Osteoporosis; Aging
Active, NR
32 Adt Sen
M-
only
N/K ? Mar-10
University of Colorado, Denver
http://ClinicalTrials.gov/show/NCT01083901
Effect of dronabinol on actual driving, simulated driving and the Standardized Field Sobriety Test. RCT (placebo) NTR1903
Dronabinol Pain N/K 24 Adt N/K Mar-10 University Maastricht (UM)
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1903
Efficacy and Safety of Salonsip Compared to Sabiá Plaster Phase III: RCT (active), Safety/Efficacy Study NCT00970658
Salonsip plaster; Sabia plaster
Contusions; Sprains; Myalgia; Pain; Tendonitis
Not yet Rec
70 Child Adt Sen
Dec-09 Feb-10 Hisamitsu Farmaceutica do Brasil Ltda
http://ClinicalTrials.gov/show/NCT00970658
Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain Phase III: RCT (placebo) NCT00647127
Buprenorphine; Fentanyl; Placebo
Pain Rec 20 Adt
M-only
Feb-08 Jan-10 University of Aarhus
http://ClinicalTrials.gov/show/NCT00647127
142
Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production Phase IV: Non-Randomized, Crossover Assignment, Pharmacodynamics Study NCT00921505
Ibuprofen; Paracetamol (acetaminophen) 1000 mg; Paracetamol + ibuprofen
Pain Comp 7 Adt May-09
Jan-10 Ullevaal University Hospital; University of Oslo
http://ClinicalTrials.gov/show/NCT00921505
Paracetamol as Antipyretic and Analgesic Medication Phase IV: Single Group Assignment, Safety/Efficacy Study NCT01070732
Paracetamol Fever; Analgesia Comp 100 Adt Sen
Jan-10 Jan-10 University of Athens
http://ClinicalTrials.gov/show/NCT01070732
Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis Phase III: RCT (active), Safety Study NCT00092742
MK0663, etoricoxib; Diclofenac sodium
Rheumatoid Arthritis; Pain relief
Comp 4000 Adt Sen
Feb-03 ? Jan-10
Merck http://ClinicalTrials.gov/show/NCT00092742
Study of Epicutaneously Applied Ketoprofen Transfersome® Gel With or Without Combination With Oral Celecoxib for the Treatment of Muscle Pain Induced by Eccentric Exercise Phase I: RCT (placebo), Safety/Efficacy Study NCT01020279
Celecoxib, Ketoprofen; Ketoprofen
Musculoskeletal Pain
Comp 80 Adt Oct-09 Dec-09 X-pert Med GmbH http://ClinicalTrials.gov/show/NCT01020279
Study to Assess Safety, Tolerability and Pharmacokinetics After Single Dose of AZD2516 to Japanese Healthy Subjects Phase I: Randomized, Parallel Assignment, Safety Study NCT00972049
AZD2516; Placebo Healthy Comp 40 Adt Sen
Sep-09 Dec-09 AstraZeneca http://ClinicalTrials.gov/show/NCT00972049
To Investigate The Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-04531083 In Healthy Male Subjects Phase I: Prospective, Cohort Study NCT00992316
PF-04531083 Pain Comp 80 Adt
M-only
Aug-09 Dec-09 Pfizer http://ClinicalTrials.gov/show/NCT00992316
143
Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects Phase I: RCT (placebo), Pharmacodynamics Study NCT00962663
ICA-105665; ibuprofen; Placebo
Nociceptive Pain; Hyperalgesia
Rec 24 Adt
M-only
Aug-09 Nov-09 Icagen http://ClinicalTrials.gov/show/NCT00962663
Protocolized vs Discretionary Use of Opioids in Acute Pain Phase III: RCT (active), Safety/Efficacy Study NCT00825370
Hydromorphone; IV opioid
Pain Rec 350 Adt Oct-08 Oct-09 Montefiore Medical Center
http://ClinicalTrials.gov/show/NCT00825370
Comparison Study of a New Combination of 2 Marketed Medications (Esomeprazole and Naprosyn) Versus Naprosyn Alone Phase I: Randomized, Crossover Assignment, Bio-availability Study NCT00992381
PN400; Naprosyn Healthy Comp 24 Adt Sep-09 Oct-09 AstraZeneca; POZEN
http://ClinicalTrials.gov/show/NCT00992381
A Safety and Effectiveness Pilot Study of PRF-108 in Healthy Volunteers Phase I/II: RCT (active), Safety/Efficacy Study NCT00883194
PRF-108; Placebo; Ropivacaine
Pain Not yet Rec
15 Adt Jul-09 Sep-09 PainReform LTD http://ClinicalTrials.gov/show/NCT00883194
A Study Comparing Norspan Patch and Oral Tramadol Phase IV: RCT (active), Safety/Efficacy Study NCT01019265
Buprenorphine 5mg, 10mg, 20mg vs Tramadol 100mg
Osteoarthritis Comp 170 Adt Sen
Mar-08 May-09 Mundipharma Pte Ltd; Mundipharma YH (Korea) is the Sponsor; C&R Reaserch Inc. is the CRO
http://ClinicalTrials.gov/show/NCT01019265
Dose-ranging Trial of OPC-249 Powder Inhalation in Patients With Pain Due to Osteoporosis Phase II: RCT (dose comparison), Safety/Efficacy Study NCT00504426
OPC-249 Pain Due to Osteoporosis
Comp 90 Adt Sen
F-
only
Jul-07 May-09 Otsuka Pharmaceutical Co., Ltd.
http://ClinicalTrials.gov/show/NCT00504426
144
Relative Bioavailability and Food Effect Study Phase I: Randomized, Crossover Assignment, Pharmacokinetics Study NCT00827515
PH797804 Pain Wtdwn 16 Adt Feb-09 May-09 Pfizer http://ClinicalTrials.gov/show/NCT00827515
Intrathecal Ketorolac in Patients With Intrathecal Morphine Dose Escalation Phase II: RCT (placebo), Efficacy Study NCT00349401
Ketorolac; Morphine
Pain Wtdwn 30 Adt Sen
Dec-06 ? May-09
Wake Forest University
http://ClinicalTrials.gov/show/NCT00349401
Single Dose Pharmacokinetics of Egalet® Hydrocodone Phase I: RCT (active), Pharmacokinetics Study NCT00802087
Hydrocodone; Hydrocodone & Acetaminophen combination
Pain Comp 28 Adt Nov-08 Apr-09 Egalet a/s http://ClinicalTrials.gov/show/NCT00802087
Civamide Patch Safety, Tolerability and PK Study Phase I: RCT (placebo), Safety Study NCT00758433
Zucapsaicin; Placebo patch
Healthy Volunteers
Comp 39 Adt Sep-08 Apr-09 Winston Laboratories
http://ClinicalTrials.gov/show/NCT00758433
First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Ascending Doses of GSK1482160. Phase I: Randomized, Parallel Assignment, Safety Study NCT00849134
GSK1482160 or placebo
Pain Rec 32 Adt Nov-08 Mar-09 GlaxoSmithKline http://ClinicalTrials.gov/show/NCT00849134
Patient-Reported Effectiveness and Safety of Arcoxia in Osteoarthritis (OA) Phase IV: Single Group Assignment, Safety/Efficacy Study NCT00757627
Etoricoxib Pain, OA Comp 500 Adt Sen
Dec-07 Feb-09 Merck http://ClinicalTrials.gov/show/NCT00757627
Effects of a Single Dose of Egalet® Morphine Combined With a Single Dose of Alcohol in Healthy Moderate Drinkers Phase I: RCT (placebo), Pharmacokinetics Study NCT00802308
Morphine sulphate Pain Comp 24 Adt Dec-08 Feb-09 Egalet a/s http://ClinicalTrials.gov/show/NCT00802308
145
Single Dose Pharmacokinetics of Egalet® Oxycodone Phase I: RCT (active), Pharmacokinetics Study NCT00801788
Oxycodone hydrochloride
Pain Comp 16 Adt Sep-08 Feb-09 Egalet a/s http://ClinicalTrials.gov/show/NCT00801788
A Study to Evaluate the Clinical Benefits of Tramadol/Acetaminophen (Ultracet) Versus Diclofenac in the Treatment of Pain in Patients With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Phase IV: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00766402
Tramadol /acetaminophen
Ankylosing Spondylitis; Pain
Term 4 Adt Sen
Sep-08 Feb-09 Johnson & Johnson Taiwan Ltd
http://ClinicalTrials.gov/show/NCT00766402
Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2066 in Young and Elderly Healthy Subjects Phase I: Randomized, Parallel Assignment, Safety Study NCT00684502
AZD2066; Placebo Pain Comp 110 Adt Sen
Jan-08 Dec-08 AstraZeneca http://ClinicalTrials.gov/show/NCT00684502
A Study To Investigate The Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-03864086 In Healthy Male Subjects Phase I: Randomized, Crossover Assignment, Pharmacokinetics/ Dynamics Study NCT00747058
PF-3864086; Placebo
Pain Comp 28 Adt
M-only
Aug-08 Dec-08 Pfizer http://ClinicalTrials.gov/show/NCT00747058
A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers Phase I: RCT (placebo) NCT00912262
Capsaicin Topical Liquid
Pain Comp 36 Adt Jun-08 Nov-08 NeurogesX http://ClinicalTrials.gov/show/NCT00912262
Safety and Efficacy of Intravenous Acetaminophen in Adult Inpatients Phase III: RCT (active), Safety/Efficacy Study NCT00598559
IV Acetaminophen Acute Pain; Fever Comp 175 Adt Sen
Jan-08 Nov-08 Cadence Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00598559
146
Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers Phase I: RCT (placebo), Pharmacodynamics Study NCT00750048
Naloxone and paracetamol
Pain Comp 12 Adt
M-only
Sep-08 Nov-08 University Hospital, Clermont-Ferrand
http://ClinicalTrials.gov/show/NCT00750048
Naproxen Sodium Extended-Release Actual Use Study Phase III: Single Group Assignment (dose comparison), Safety/Efficacy Study NCT00751400
Naproxen Sodium ER (BAYH6689)
Pain Comp 466 Child Adt Sen
Jul-08 Nov-08 Bayer; Pegus Research, Inc.
http://ClinicalTrials.gov/show/NCT00751400
Naproxen Sodium ER Pharmacokinetic Study Phase I: Randomized, Crossover Assignment, Bio-availability Study NCT00818415
Naproxen sodium ER (BAYH6689); Commercial Naproxen (Aleve, BAYH6689)
Pain Comp 32 Adt Nov-08 Nov-08 Bayer http://ClinicalTrials.gov/show/NCT00818415
Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab Phase IV: Non-randomized, Parallel Assignment, Safety/Efficacy Study NCT00510536
Acetaminophen; NSAID
Arthritis; Arthralgia
Comp 50 Adt Sen
Jul-07 Oct-08 Probity Medical Research
http://ClinicalTrials.gov/show/NCT00510536
Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers Phase I: Randomized, Crossover Assignment, Pharmacodynamics Study NCT01119222
Gabapentin; Diphenhydramine; Morphine; Placebo
Healthy Comp 19 Adt
M-only
Jul-08 Oct-08 Pfizer http://ClinicalTrials.gov/show/NCT01119222
Protocolized vs Nonprotocolized Treatment of Adult ED Patients With Acute Severe Pain Phase III: Randomized, Parallel Assignment, Safety/Efficacy Study NCT00627367
Hydromorphone; Nonprotocolized
Acute Pain Active, NR
224 Adt Oct-07 Oct-08 Montefiore Medical Center
http://ClinicalTrials.gov/show/NCT00627367
147
Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Subjects With Rheumatoid Arthritis Phase II: Randomized, Cross-over Assignment, Safety/Efficacy Study NCT00626275
ADL5859; naproxen; Placebo; Lactose monohydrate, NF
Rheumatoid Arthritis
Comp 60 Adt Sen
Oct-07 Sep-08 Adolor Corporation http://ClinicalTrials.gov/show/NCT00626275
Safety and Speed of Onset of a Fixed Dose of Intravenous Hydromorphone in the Treatment of Adult Patients Presenting to the Emergency Department With Acute Severe Pain Phase IV: Non-randomized, Parallel Assignment, Safety/Efficacy Study NCT01006850
Hydromorphone Acute Pain Comp 300 Adt Sep-08 Montefiore Medical Center
http://ClinicalTrials.gov/show/NCT01006850
Characterization of the Analgesic Effects of Oral THC and Smoked Marijuana in Non-Treatment Seeking Marijuana Smokers Phase II: Single Group Assignment, Efficacy Study NCT00743119
Oral THC; Marijuana
Pain; Mood Rec 48 Adt
F-only
Jun-08 ? Aug-08
New York State Psychiatric Institute; Research Foundation for Mental Hygiene; National Institute on Drug Abuse
http://ClinicalTrials.gov/show/NCT00743119
Study to Investigate Safety, Tolerability and Pharmacokinetics of a Single Ascending Dose of AZD1704 Phase I: Randomized, Parallel Assignment, Safety Study NCT00692042
AZD1704 Pain Comp 80 Adt Mar-08 Jun-08 AstraZeneca http://ClinicalTrials.gov/show/NCT00692042
Other including CAM therapies
Nurse-led Clinic for Patients With Rheumatic Diseases and Biological Treatment RCT (active) NCT01071447
Nurse-led clinic vs rheumatologist-led clinic
Rheumatic Diseases
Rec 100 Child Adt Sen
Oct-09 Oct-12 Spenshult Hospital; The Swedish Rheumatism Association; County Council of Halland, Sweden
http://ClinicalTrials.gov/show/NCT01071447
148
Bringing Acute and Wellness Care to Underserved Populations Using Traditional Chinese Medicine Single Group Assignment, Efficacy Study NCT01059487
Traditional Chinese Medicine
Pain Management; Traditional Chinese Medicine
Not yet Rec
Adt Sen
Sep-10 Aug-12 Chicago College of Oriental Medicine|Agency for Healthcare Research and Quality (AHRQ)|QualityMetric Incorporated|Inspire Tech Group
http://ClinicalTrials.gov/show/NCT01059487
Using Diffuse Noxious Inhibitory Control (DNIC) to Predict Acupuncture Therapy Outcome: A Pilot Study Single Group Assignment, Efficacy Study NCT01088867
Acupuncture Pain Rec 10 Adt Mar-10 Jan-11 University of Washington; Bastyr University
http://ClinicalTrials.gov/show/NCT01088867
The effect of using copper heelers in alleviating joint and musculoskeletal aches and pains RCT (placebo) ISRCTN42466047
Copper heelers; Placebo heeler
Musculoskeletal pain and aches
Comp 200 Adt Sen
Mar-10 Mar-10 University of Wolverhampton Corporate Services Ltd (UK)
http://www.controlled-trials.com/ISRCTN42466047
Does Auricular Acupuncture Improve Tolerance to Electromyography (EMG) Testing? Phase I: RCT (active), Efficacy Study NCT01017211
Auricular acupuncture
Pain Rec 36 Adt Sep-09 Jun-10 Kessler Foundation http://ClinicalTrials.gov/show/NCT01017211
Improving the provision of pain treatment for nursing home residents through consistent pain assessment - implementation of an algorithm for pain assessment (NRS - VRS - BESD) in nursing homes RCT (active) DRKS00000327
Nurse-training on pain with implementation of algorithm; Nurse-training on pain only
Pain; Older people
N/K 350 Sen Oct-09 > Dec-09
Akademisches Krankenhaus der Universität Ulm
http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000327
Effectiveness of early part-time sick leave in musculoskeletal disorders RCT ISRCTN30911719
Part-time sick leave; full-time sick leave
Musculoskeletal disorders
Comp 600 Adt Jan-08 Jun-09 Finnish Institute of Occupational Health
http://www.controlled-trials.com/ISRCTN30911719
149
Miscellaneous observational studies
Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica Prospective, Case-Control StudyProspective NCT00847236
Polymyalgia Rheumatica; Rheumatoid Arthritis; Rheumatic Disease
Rec 150 Adt Sen
Jan-09 Mar-11 Lahey Clinic http://ClinicalTrials.gov/show/NCT00847236
A survey of GPs views on the prognosis of osteoarthritis - The prognosis of joint pain in the older adult : GPs views on discussing and estimating prognosis Cross-sectional, Cohort Study UKCRN ID 7722
Joint pain; OA Active 500 Adt Sen
N/K Dec-10 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=7722
Preventing pain from interfering with later life: an action oriented qualitative study UKCRN ID 7916
Pain Active 60 N/K N/K Oct-10 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=7916
Cognitive Testing for the Pain Quality Assessment Scale (PQAS) Prospective, Cross-Sectional, Case-Control Study NCT00715598
Pain; Spinal Cord Injuries; Multiple Sclerosis; Diabetes Complications
Enrolling by
invitation
225 Adt Sen
Jun-08 Aug-10 University of Washington; Merck
http://ClinicalTrials.gov/show/NCT00715598
MRI Study of Musculoskeletal Function NCT00051857
Healthy Rec 500 Child Adt
Jan-03 ? Jun-10
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
http://ClinicalTrials.gov/show/NCT00051857
Natural History of Rheumatic Diseases in Minority Communities NCT00024479
Rheumatic Disease
Rec N/K Adt Sen
Sep-01 ? Mar-10
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
http://ClinicalTrials.gov/show/NCT00024479
Distraction from pain in Fibromyalgia, Arthritis and healthy volunteers Observational UKCRN ID 4779
Fibromyalgia; Pain; Arthritis
Active 48 N/K N/K Dec-09 N/K http://public.ukcrn.org.uk/Search/ StudyDetail.aspx?StudyID=4779
150
Acute Pain Episodes in Patients Under Opioid Maintenance Therapy : Clinical Management and Long Term Effects Prospective, Cohort Study NCT00738036
Acute Pain Comp 150 Adt Sen
Apr-08 Nov-09 University Hospital, Toulouse; French Health Products Safety Agency
http://ClinicalTrials.gov/show/NCT00738036
Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases NCT00069342
Rheumatic Diseases
Comp 140 Adt Sen
Sep-03 ? Nov-09
National Institutes of Health Clinical Center (CC)
http://ClinicalTrials.gov/show/NCT00069342
Additional Positron Emission Tomography (PET) Scan of Brain in Patients Undergoing PET Scan for Diseases Unrelated to Brain Prospective, Cohort Study NCT00729092
Pain Active, NR
100 Adt Sen
May-08
Oct-09 Rush University Medical Center
http://ClinicalTrials.gov/show/NCT00729092
Elaboration of a patient derived score to measure osteoarthritis impact of diseas based on a patient's perception of pain and functional disability an OARSI-OMERACT initiative UKCRN ID 6482
OA; Pain; Disability
Comp 200 N/K N/K Jul-09 Chapel Allerton Hospital, Leeds, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=6482
Investigating the Impact of Mode of Administration on Item Response Cross-Sectional NCT00783991
Chronic Obstructive Pulmonary Disease; Depression; Rheumatoid Arthritis
Not yet Rec
800 Adt Sen
Apr-09 May-09 National Institutes of Health (NIH); QualityMetrics; Stony Brook University; NorthShore University HealthSystem Research Institute; Stanford University
http://ClinicalTrials.gov/show/NCT00783991
PASCOE-Agil HOM-Injektopas in the Treatment of Rheumatic Disorders Prospective, Cohort Study NCT00922428
Rheumatic Disorders; Arthralgia; Myalgia; Lumbago
Comp 1389 Adt Sen
Jan-09 May-09 Pascoe Pharmazeutische Praeparate GmbH
http://ClinicalTrials.gov/show/NCT00922428
The prognosis of musculoskeletal pain in primary care 2 UKCRN ID 5968
Musculoskeletal pain
Comp 328 Adt Sen
N/K Apr-09 Keele University, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=5968
151
The Role of Sustained Attention in Regulating Pain UKCRN ID 4780
Musculoskeletal pain
Susp 36 N/K N/K Dec-08 Hope Hospital, Manchester, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4780
The Expectancy of Pain in Fibromyalgia, Osteoarthritis and Healthy Volunteers UKCRN ID 4784
Pain; OA; Fibromyalgia; Healthy
Comp 48 N/K N/K Dec-08 Hope Hospital, Manchester, UK
http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=4784
Assessing the Impact of MOVALIS in Osteoarthritis and Rheumatoid Arthritis Patients on Health Related Quality of Life Prospective, Cohort Study NCT00619177
Osteoarthritis; Arthritis, Rheumatoid
Comp 3569 Adt Sen
Mar-07 May-08 Boehringer Ingelheim Pharmaceuticals
http://ClinicalTrials.gov/show/NCT00619177
Observational Study on the Patients With Pain Medications Prospective, Cohort Study NCT00771212
Pain Comp 2636 Adt Sen
May-08 Johnson & Johnson Taiwan Ltd
http://ClinicalTrials.gov/show/NCT00771212