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HIV Vaccines: where are we, where

are we going, and how can we getthere faster?

16 July 2010

Alan Bernstein, O.C., Ph.D.Executive Director,

Global HIV Vaccine Enterprise

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Adapted from UNAIDS, December 2009

Estimated Number of Adults and ChildrenNewly Infected with HIV, 2008

Western &Central Europe

30 00030 000[23 000[23 000 35 000]35 000]

Middle East & North Africa35 00035 000[24 000[24 000 46 000]46 000]

Sub-Saharan Africa1.9 million1.9 million

[1.6[1.6 2.2 million]2.2 million]

Eastern Europe& Central Asia

110 000110 000[100 000[100 000 130 000]130 000]

South & South-East Asia280 000280 000

[240 000[240 000 320 000]320 000]

Oceania39003900

[2900[2900 5100]5100]

North America55 000

[36 000 61 000]

Latin America170 000170 000

[150 000[150 000 200 000]200 000]

East Asia75 00075 000

[58 000[58 000 88 000]88 000]Caribbean20 000

[16 000 24 000]

Total: 2.7 million (2.4 3.0 million)

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An Unsustainable Economic Situation

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HIVPreventionModalities

Vaccine

PrEP

Partnerreduction

Circumcision

Drug/alcoholtreatment

Test andtreat

Microbicides

Condoms

Education

Prevention Approaches and Biomedical Interventions

Adapted from A. Fauci, NIH, 2009

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Effective in high-riskpopulations

Protection againstdiversity of HIV

strains

Durable, safe and

effective

Globally

accessible

GLOBALLYEFFECTIVE HIVVACCINE

Adapted from M. Robb, MHRP, 2010

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How an HIV VaccineMight Work

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Timeline Between Disease Identification and VaccineDevelopment

1900

whooping cough

polio

measles

hepatitis B

Streptococcal meningitis

1980

typhoid

chickenpox

rotavirus

HPV

HIV

cytomegalovirus

tuberculosis

malaria

yellow

fever

diphtheria

tetanus

hep. A

hepatitis C

Haemophilus influenza B

mumps

rubella

influenza

1920 1940 1960 2000

tick encephalitis

jap. encephalitis

Vaccine available

Partially-effective vaccine

No vaccine

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Fundamental

research

New vaccine

strategies

Product development and

animal testing

Clinical researchPhase 1 and II trials

Efficacy trials

How do we Develop Vaccines?

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Hope for an HIV Vaccine

RV144 Modified Intention-to-Treat

Analysis

Source: Rerks-Ngarm et al. Vaccination with ALVAC and AIDSVAX to Prevent HIV-I

Infection in Thailand. N Engl Med2009; 361.

First proof of concept: a

vaccine is possible

Need to understand how

vaccine reduced risk of HIV

acquisition

Important implications for

future HIV vaccine designand testing

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An Important Moment in HIV Vaccine Research

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EMBARGOED UNTIL 11:15 a.m. CST Sunday, 18 July

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The 2010 Plan: The Framework For A New Era of HIV VaccineResearch

Developed by the Enterprise Council involving the

Enterprise Science Committee and five Working Groups

Input of more than 400 researchers, policy-makers,

funders and advocates worldwide An agreement of partners to align their independent

strategies to maximize opportunities for cooperation in

HIV vaccine research

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v

Transforming the Global HIV Vaccine Research Effort

New minds and new

ideas

Unified clinical trials

agenda

Rapid data sharing

Broaden and increase funding

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v

AIDS Vaccine

Asian Network

Global HIV Vaccine Enterprise:Promoting Scientific Collaboration

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Upcoming Enterprise 2010 Plan Activities

AIDS 2010, Vienna (18 23 July)1. Satellite Session: The Search for an HIVVaccine: Where are we, where are we

going, and how can we get there faster?

11:15 13:15, Mini Room 6

2. Press Conference: Entering the Next Phase in HIV Vaccine Research, the Future

Course of the Field

Monday, 19 July 12:00 13:00, Press Room 1

3. Vaccine Session: HIV Vaccines Quo Vadis?

Tuesday, 20 July 14:30 16:00, Session Room 3

4. Enterprise Booth

Section E, booth 476

AIDS Vaccine 2010, Atlanta (28 Sept. 1 Oct.)

1. Plenary Session: Launch of the Global HIVVaccine Enterprise 2010 Plan

Wednesday, 29 September 14:30 - 16:00