Histone modification map | Human1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 M P 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50S E T A P A A P A A P A P A E K T P V K K K A R K S A G A A K R K A S G P P V S E L I T K A V A A S

51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100K E R S G V S L A A L K K A L A A A G Y D V E K N N S R I K L G L K S L V S K G T L V Q T K G T G A

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 P 146 147 148 149 150S G S F K L N K K A A S G E A K P K A K K A G A A K A K K P A G A A K K P K K A T G A A T P K K S A

151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 P 172 173 174 175 176 177 178 179 180 181 182 183 184 185 P 187 188 189 190 191 192 193 194 195 196 197 198 199 200K K T P K K A K K P A A A A G A K K A K S P K K A K A A K P K K A P K S P A K A K A V K P K A A K P

201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218K T A K P K A A K P K K A A A K K K

P 2 3 4 A 6 7 8 A 10 11 12 A 14 A 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 A 37 38 39 40 41 42 43 44 45 46 47 48 49 50S G - - R G K Q G G K A R A K A K S R S S R A G L Q F P V G R V H R L L R K G N Y A E - R V G A G A P V YS G - - R G K T G G K A R A K A K S R S S R A G L Q F P V G R V H R L L R K G H Y A E - R V G A G A P V YA G G K A G K D S G K A K T K A V S R S Q R A G L Q F P V G R I H R H L K S R T T S H G R V G A T A A V Y

P R R R R R R G S S G A G G R G R T C S R T V R A E L S F S V S Q V E R S L R E G H Y A Q - R L S R T A P V YS S - - R G - - - G K K K S T K T S R S A K A G V I F P V G R M L R Y I K K G H P K Y - R I G V G A P V Y

M

51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 M 100M A A V L E Y L T A E I L E L A G N A A R D N K K T R I I P R H L Q L A I R N D E E L N K L L G K VL A A V L E Y L T A E I L E L A G N A A R D N K K T R I I P R H L Q L A I R N D E E L N K L L G G VS A A I L E Y L T A E V L E L A G N A S K D L K V K R I T P R H L Q L A I R G D E E L D S L I - K AL A A V I E Y L T A K V L E L A G N E A Q N S G E R N I T P L L L D M V V H N D R L L S T L F N T TM A A V L E Y L T A E I L E L A G N A A R D N K K G R V T P R H I L L A V A N D E E L N Q L L K G V

U f*101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 M 119 P 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 P 137 138 P 140 141 142T I A Q G G V L P N I Q A V L L P K K T E S H H K A K G KT I A Q G G V L P N I Q A V L L P K K T S A T V G P K A P S G G K K A T Q A S Q E YT I A G G G V I P H I H K S L I G K K - - G Q Q K T VT I S Q - - V A P G E DT I A S G G V L P N I H P E L L A K K R G S K G K L E A I I T P P P A K K A K S P S (140 - 235 G G K E 240 - 370) N

M M

1 2 3 4 5 6 7 8 9 10 11 12 13 P 15 16 17 18 19 20 21 22 M 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 M 44 45 46 47 48 49 50P E P A K S A P A P K K G S K K A V T K A Q K K D G K K R K R S R K E S Y S V Y V Y K V L K Q V H P

A A A A A

51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100D T G I S S K A M G I M N S F V N D I F E R I A G E A S R L A H Y N K R S T I T S R E I Q T A V R L

A

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 U 121 122 123 124 125L L P G E L A K H A V S E G T K A V T K Y T S S K

A A A

CIT CIT CIT CITor or or or

1 M P M 5 6 7 M M P P 12 13 14 15 16 M 18 19 20 21 22 M 24 25 M A P 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50A R T K Q T A R K S T G G K A P R K Q L A T K A A R K S A P A T G G V K K P H R Y R P G T V A L R EA R T K Q T A R K S T G G K A P R K Q L A T K A A R K S A P S T G G V K K P H R Y R P G T V A L R E

A A A M P

51 52 53 54 55 M 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 M 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100I R R Y Q K S T E L L I R K L P F Q R L V R E I A Q D F K T D L R F Q S S A V M A L Q E A C E A Y LI R R Y Q K S T E L L I R K L P F Q R L V R E I A Q D F K T D L R F Q S A A I G A L Q E A S E A Y L

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135V G L F E D T N L C A I H A K R V T I M P K D I Q L A R R I R G E R AV G L F E D T N L C A I H A K R V T I M P K D I Q L A R R I R G E R A

P 2 M 4 5 6 7 8 9 10 11 M 13 14 15 16 17 18 19 M 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 P 48 49 50S G R G K G G K G L G K G G A K R H R K V L R D N I Q G I T K P A I R R L A R R G G V K R I S G L I

A A A A A

51 52 53 54 55 56 57 58 M 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 M 93 94 95 96 97 98 99 100Y E E T R G V L K V F L E N V I R D A V T Y T E H A K R K T V T A M D V V Y A L K R Q G R T L Y G F

A A A

101 102G G

1 2 3 4 5 6 P 8 M 10 11 12 13 14 15 16 P 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50M G P R R R S R K P E A P R R R S P S P T P T P G P S R R G P S L G A S S H Q H S R R R Q G W L K E

A

51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100I R K L Q K S T H L L I R K L P F S R L A R E I C V K F T R G V D F N W Q A Q A L L A L Q E A A E A

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140F L V H L F E D A Y L L T L H A G R V T L F P K D V Q L A R R I R G L E E G L G

H1.4 (P10412)

H1.0 (P07305)H1.1 (Q02539)H1.2 (P16403)H1.3 (P16402)H1.5 (P16401)H1.x (P92522)

H2A (Q6FI13)H2A.X (P16104)H2A.Z (P0C0S5)

H2A.BbD (P98176)MacroH2A.1(O75367)

H2A (Q6FI13)H2A.X (P16104) H2A.Z (P0C0S5)

H2A.BbD (P98176)MacroH2A.1(O75367)

H2A (Q6FI13)H2A.X (P16104) H2A.Z (P0C0S5)

H2A.BbD (P98176)MacroH2A.1(O75367)

H2B (P62807)

H3.1 (P68431)H3.3 (P84243)

H3.1 (P68431)H3.3 (P84243)

H3.1 (P68431)H3.3 (P84243)

H4 (P62805)

CENP-A (P49450)

d* e*

Acetylated Biotinylated Citrullinated Methylation

Methylated + Acetylated Phosphorylated Ubiquitination Non-identical amino acids

Also referred to in the literature as | a* : S122 | b* : T126 | c* : S129 | d* : K26 | e* : S27 | f* : T119

A CIT M

M

A P URED

RESIDUES

Key:

www.abcam.com