Packaging Technology

High-shear mixer granulator systemsMixing, Granulating, Drying

2 | High-shear mixer granulator systems

Shortening the time between product development and market launch and raising efficiency in production while maintaining maximum quality are decisive factors for our customers. The development of the Hüttlin high shear mixer granulator responds to precisely these demands. Gentlewing, SmartFlow and UltraClean have become synonyms for innovative technology for the benefit of customers. Gentlewing is at the core of all Hüttlin units – available in an identical design with bottom-drive or top-drive technology.

SmartFlowZ-shape of Gentlewing

Bottom Drive Top Drive

Superior mixing and granulationThanks to the Hüttlin Gentlewing impeller, wall caking and incomplete emptying are things of the past. The impeller shape matches the contour of the mixing container and its angled impeller plate ensures a forced mixing

Use the technological lead

High-shear mixer granulator technology

of the product. The precise manufacturing of the Hüttlin high-shear mixer granulator ensures a defined granulation gap along the entire length of the impeller plate, so that a considerably larger surface is used for granulation.

High-shear mixer granulator systems | 3

Form follows functionWith the HTG (Hüttlin Top-Drive Granulator) and HBG (Hüttlin Bottom-Drive Granulator), Hüttlin has a high-shear mixer granulator to meet every requirement. Gentlewing with all of its benefits is available for use in either version. The Hüttlin high-shear mixer granulator with bottom drive is the best

Principle of the Gentlewing impeller

Granulation gap

choice for simple granulation applications in combination with a fluid bed dryer. The top-drive version satisfies the highest of demands. A SinglePot application using UltraClean, SmartFlow, vaccuum drying with solvent recovery system can be extended with a high containment design module.

4 | High-shear mixer granulator systems

HBG 600▶ Bottom Drive ▶ Inline operation▶ UltraClean – optional

HBG Hüttlin bottom drive High-shear mixer granulator

The innovative classicHüttlin has set another milestone with its shaft seal design. Thanks to the intelligent design and continuous flushed seal, it is no longer necessary to lift or remove the impeller for cleaning. The combination of double lip seal and wiper, flush seal, is designed as a cartridge and has the same mounting dimensions as the optional mechanical

seal. Consequently it can be easily replaced. All of the GMP requirements and pharmaceutical environment standards are met. For easy cleaning all utility connections are located in the base frame of the machine. The lifting mechanism of the container lid was also developed with this in mind. The lid is raised vertically to improve house keeping in the process area.

Lifting mechanism

High-shear mixer Fluid bed

High-shear mixer granulator systems | 5

HTG 600 opened ▶ Top Drive ▶ SinglePot▶ Inline operation▶ UltraClean

HTG 600 with wet mill

HTG Hüttlin top drive High-shear mixer granulator

Innovation and GMP requirements combinedThe flexibility of a stand-alone unit as a SinglePot or in combination with the proven fluid bed technology ensures granulation and drying processes with maximum efficiency.

The HTG high-shear mixer granulators with top-drive technology differ from those with bottom-drive technology

in that the seals of the Gentlewing and chopper do not come into contact with the product. This significantly reduces wear and tear on the seal and the danger of contaminating the product. HTG is characterized by features such as lifting columns for the product container, the extreme ease with which cleanliness can be checked, ultra-fast emptying times and minimum effort in changing products.

Mixing, Granulating, Drying

SinglePot

High-shear mixer Fluid bed

6 | High-shear mixer granulator systems

Heated product container

Heated impeller shaft Heated lid SmartFlow,

360° strip gas feeding Discharge valve Gentlewing Chopper Temperature

measurement Cleaning nozzles Filter Vacuum pump Condensation unit Video camera

SinglePot: Consistent implementation of the benefits of top-drive technology

The Gentlewing along with the SmartFlow continuous strip gas feeding system replaces expensive, high-maintenance accessories such as tilting options or microwave technology with comparable drying times. The wall installation enables true separation of the GMP and technical areas. All drives and supply lines can

be accessed via the technical area. The logical consequence is to upgrade this unit with the UltraClean concept, split valves and additional options from the Hüttlin product range to create a genuine high-end containment unit.

The SinglePot version of the Hüttlin high-shear mixer granulator combines all of the benefits of the top-drive concept with the specific features SmartFlow, heating jacket, product temperature regulation and vacuum drying with solvent recovery. This concept meets the highest requirements with regard to process times, product quality and handling.

High-shear mixer granulator systems | 7

From left to right: SmartFlow, metal filter, discharge valve

GMP-compliant design

There are things that do not compromise. The Hüttlin high-shear mixer combines a modular structure with implementation of GMP requirements. The modular structure offers maximum flexibility in terms of adapting the unit to the specific customer requirements. Consequent

implementation of the highest hygienic requirements translates into a significant increase in validation, cleaning and production efficiency. When compared with conventional high-shear mixer granulators these are key benefits.

Gentlewing

▶ Maximum mixing quality with minimum mechanical stress on the product

▶ Minimum wall caking due to very close clearances between the product vessel and Gentlewing

▶ Excellent discharge due to Z-design of the Gentlewing impeller

▶ Effective drying without tilting or microwave technology

SmartFlow▶ Highly efficient gas distribution over 360° for considerably higher drying homogeneity

▶ Shorter drying times due to continuous, effective strip gas feeding

Discharge valve▶ The discharge valve design enables uninterrupted discharge, as the discharge velocity is not controlled by means of the valve opening, but by extremely low impeller speed

UltraClean▶ The first CIP concept, which significantly reduces cleaning times and ensures highest cleaning quality

8 | High-shear mixer granulator systems

The variety in requirements on modern control systems means that it must be possible to adjust them flexibly. Hüttlin’s control systems were developed based on this premise. Their modular structure can be adapted very easily, from control of an individual machine to entire production lines and integration into ME-systems.

Based on a Siemens or Allan Bradley PLC, the control system was consistently developed according to GAMP guidelines and is extended to include a PC above a certain scope. Provicon fulfills all requirements of the FDA 21 CFR part 11.

PAT IntegrationProcess monitoring is one of the most important measures for meeting and reproducing the required quality.

Device control and process monitoring

In addition to monitoring conventional indicators such as temperature, torque, pressure and flow rate for liquid binder and strip gas, Hüttlin provides monitoring of product humidity and particle size distribution. A NIR (Near Infrared) sensor can be integrated for inline monitoring of the product quality, residual humidity, mixing quality and particle size distribution.

High-shear mixer granulator systems | 9

The cleaning requirements for high-shear mixer granulators from Hüttlin can adapt to the customer’s process requirements. From WIP (Washing in Place) to the CIP (Cleaning in Place) solution, the common denominator for all of the cleaning concepts is efficiency.

Cleaning concept

Cleaning – WIP and CIP

Cleaning nozzle

M

Filter

Vacuum pump

High-shear mixer

Pneumatic �lling

A 1

A 2E

B

C

DM

MA 1-2B CD EF

Cold water

Hot waterDI water

F

Detergent

To Fluid bed

10 | High-shear mixer granulator systems

L

H

W

H

L

W

HTGHBG

Technical data subject to alterations *Depending on discharge container respectively discharge unit

Technical Data (Standard unit)

300 400 600 800 1 200 1 800HBG

Total volume (litres) 300 400 600 800 1 200 1 800

Power (kW) 27 31 39 49 68 88

Length L (up to wall; mm) 1 800 1 845 1 925 2 120 2 600 2 650

Width W (mm) 1 400 1 460 1 560 1 560 2 160 2 200

Height H (mm)* 3   400 3 800 4 400 4 400 5 500 5 600

300 400 600 800 1 200 1 800HTG

Total volume (litres) 300 400 600 800 1 200 1 800

Power (kW) 27 31 39 46 68 88

Length L (mm) 2 100 2 120 2 250 2 600 3 500 3 700

Width W (mm) 1 120 1 150 1 270 1 270 1 480 1 800

Height H (mm)* 3 100 3 200 3 500 3 600 4 050 4 200

High-shear mixer granulator systems | 11

Discharge valve HBG 600

Product overview / dimensions High-shear mixer granulator/dryer

HBG – Bottom Drive HTG – Top DriveStandard systems HBG 300 HTG 300

HBG 400 HTG 400

HBG 600 HTG 600

HBG 800 HTG 800

HBG 1 200 HTG 1 200

HBG 1 800 HTG 1 800

UltraClean HBG 300UltraClean HTG 300UltraClean

HBG 400UltraClean HTG 400UltraClean

HBG 600UltraClean HTG 600UltraClean

HBG 800UltraClean HTG 800UltraClean

HBG 1200UltraClean HTG 1 200UltraClean

HBG 1800UltraClean HTG 1 800UltraClean

SinglePot SinglePot 300 SinglePot 300UltraClean

SinglePot 400 SinglePot 400UltraClean

SinglePot 600 SinglePot 600UltraClean

SinglePot 800 SinglePot 800UltraClean

SinglePot 1 200 SinglePot 1 200UltraClean

SinglePot 1 800 SinglePot 1 800UltraClean

Hüttlin GmbHA Bosch Packaging Technology Company

Hohe-Flum-Straße 42 79650 Schopfheim GermanyPhone +49 7622 6884-0Fax +49 7622 6884-111www.boschpackaging.com info.packaging-scm@bosch.com

PAD

H |

04.1

4 | 1

00 %

chl

orin

e fr

ee p

aper

| ©

All

righ

ts r

eser

ved