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Inpharma 1516 - 3 Dec 2005 High-dose dexamethasone increases soluble P- selectin and von Willebrand factor (vWF) levels in healthy men, according to researchers from Austria and the UK. Their crossover study involved nine healthy male volunteers who each received IV dexamethasone 0.04 mg/kg and 1 mg/kg (high dose), and placebo, twice daily for 2 days each. There was a 6-day washout period between phases. The researchers found that levels of vWF were significantly increased from baseline at 24 and 48 hours following the administration of high-dose dexamethasone. Plasma levels of sP-selectin only showed significant increases from baseline 48 hours after the administration of high-dose dexamethasone. The researchers suggest that the probable mechanism for the increase in vWF levels was dexamethasone- induced up-regulation of vWF-mRNA. Jilma B, et al. High dose dexamethasone increases circulating P-selectin and von Willebrand factor levels in healthy men. Thrombosis and Haemostasis 94: 797-801, No. 4, Oct 2005 801023537 1 Inpharma 3 Dec 2005 No. 1516 1173-8324/10/1516-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

High-dose dexamethasone increases P-selectin, vWF levels

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Inpharma 1516 - 3 Dec 2005

■ High-dose dexamethasone increases soluble P-selectin and von Willebrand factor (vWF) levels inhealthy men, according to researchers from Austriaand the UK. Their crossover study involved ninehealthy male volunteers who each received IVdexamethasone 0.04 mg/kg and 1 mg/kg (high dose),and placebo, twice daily for 2 days each. There was a6-day washout period between phases. Theresearchers found that levels of vWF were significantlyincreased from baseline at 24 and 48 hours followingthe administration of high-dose dexamethasone.Plasma levels of sP-selectin only showed significantincreases from baseline 48 hours after theadministration of high-dose dexamethasone. Theresearchers suggest that the probable mechanism forthe increase in vWF levels was dexamethasone-induced up-regulation of vWF-mRNA.Jilma B, et al. High dose dexamethasone increases circulating P-selectin andvon Willebrand factor levels in healthy men. Thrombosis and Haemostasis 94:797-801, No. 4, Oct 2005 801023537

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Inpharma 3 Dec 2005 No. 15161173-8324/10/1516-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved