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Hepatitis web study Source: Reddy KR, et al. Lancet Infect Dis. 2015;15: Simeprevir vs Telaprevir with Peginterferon + Ribavirin in GT1 ATTAIN: Study Design HCV GT-1 Treatment Experienced Week Simeprevir Peginterferon + Ribavirin Telaprevir Peginterferon + Ribavirin Drug Dosing Simeprevir: 150 mg once daily Telaprevir: 750 mg three times daily Peginterferon alfa-2a (PEG): 180 mcg/week Ribavirin (RBV) weight-based (in 2 divided doses): 1000 mg if < 75kg or 1200 mg/day if ≥ 75kg SVR12 N = 379 N = 384

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