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Hematopoiesis Simplified: Part 1 Erythropoiesis
Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 1 Erythropoiesis
Objectives are to:• Identify the developmental cells of
erythropoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow
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Blood vessel
Bone marrow
19761
Bloodin vessel
Peripheral blood
ErythrocytesReticulocytes
21
Erythrocytes
Reticulocytes
Orthochromatophilicerythroblasts
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
No nucleus and red cytoplasm
No nucleus and blue - grey cytoplasm
Dark, small, spherical nucleusblue – grey cytoplasm
Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm
Fractured, spherical nucleus andthin rim of dark blue cytoplasm
Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm
Erythropoiesis
McGraw-Hill Companies
Orthochromatophilic erythroblasts
Erythrocytes
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
Reticulocytes
Erythropoiesis
Erythropoiesis
Erythrocytes
Orthochromatophilic erythroblasts
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Polychromatophilic erythroblasts
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Basophilic erythroblast
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Proerythroblasts
Reticulocytes
ErythrocytesOrthochromatophilic erythroblastsErythropoiesis
Early orthochromatophilic erythroblasts
Late polychromatophilic erythroblasts
Polychromatophilic erythroblasts Early polychromatophilic erythroblasts
Basophilic erythroblasts Proerythroblasts
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Polychromatophilic erythroblast
Orthochromatophilicerythroblasts
Basophilic erythroblast
Proerythroblast
Late polychromatophilic erythroblast
Eosinophil orbasophil
RBCs
platelets
Reticulocyte
Erythrocytes
Bone marrow
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Reticulocyteenteringblood vessel
Blood vessel
The End of Hematopoiesis Simplified: Part 1 Erythropoiesis
• Granulopoiesis is next
Hematopoiesis Simplified: Part 2 Granulopoiesis
Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 2 Granulopoiesis
Objectives are to:• Identify the developmental cells of granulopoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow32583
Bone marrow19761
Blood
Blood
`Bone marrow
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Developing granulocytes
21
Peripheral blood
Neutrophilicmetamyelocytes
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic band or stab cells
Lobulated, dark nucleus, mature grey cytoplasm with small granules
Horse-shoe shaped, darkening nucleus, grey mature cytoplasm
Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent
Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules
Large, oval, non-indented nucleus,large amount of sky blue cytoplasm with non-specific granules
Granulopoiesis
Neutrophilicband cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
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Neutrophilic myelocytes
Neutrophilic metamyelocyte
Neutrophil
Eosinophil orbasophil
Platelets
Neutrophilic metamyelocytes
Neutrophilicband cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
Neutrophilic metamyelocytes
Neutrophilicband cellsLymphocytes Neutrophilic
myelocytes
Lymphocytes
Neutrophilic band cell
Unknown nuclei Promyelocyte
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Neutrophilicband cells
Neutrophilic band cells
Neutrophils
Granulopoiesis
Early neutrophilicmetamyelocytes
Neutrophilicmetamyelocytes
Neutrophilic myelocytes
Late promyelocytes Promyelocyte
Neutrophilic metamyelocytes
Proerythroblast
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Orthochromatophilicerythroblasts
Orthochromatophilicerythroblasts
Unknown nuclei
Eosinophils or basophils
Neutrophilicband cells
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White blood cell entering a blood vessel
Bone marrow
Blood vessel
Blood vessel
The End of Hematopoiesis Simplified: Part 2 Granulopoiesis
