Heart Failure Patophysiologic & Clinical Aspect Arie
Bachtiar Dwitaryo Cardiology Division Dr Kariadi Hospital
Semarang
Heart FailurePatophysiologic & Clinical Aspect
Arie Bachtiar DwitaryoCardiology Division Dr Kariadi
HospitalSemarang
DefinitionCHF is a complex clinical syndrome caharacterized by
dysfunction of the left-right or both ventricles and changes in
neurohumoral regulationThis syndrome consist of :Exercise
intoleranceDisrythmiaLV-RV DysfunctionFluid Retention : Pretibial
Edema, Ascites, Pulmonary Edema
Definition of Heart FailureHeart failure is the
pathophysiological state in which the heart is unable to pump blood
at a rate commensurate with the requirements of the metabolizing
tissues or can do so only from an elevated filling pressure.Heart
failure is a complex clinical syndrome that can result from any
structural or functional cardiac disorder that impairs the ability
of ventricle to fill with or eject blood.
Mechanism of deathSudden death 40%Worsening CHF 40%Other
20%Further damageExcessive wall stressNeurohormonal
activationMyocardial ischemiaProgressionAnnual mortality
