Tn.rirnn, Vol. 26. No . 12, p. 1229, 1988 .

0041-0IOI~RR 53 .00+,00Printed in Grcat Britain.

i~ 19RR Pcr~tamon Press plc

REVIEWS

HOCKWIN, O. (Ed.) Drug-Induced Ocular Side Effects and Ocular Toxicology, Concepts in Toxicology, Vol. 4,423 pp . Basel: Karger (1987) .

IN HISvolume papers are assembled, which were presented at the 5th International Symposium on Drug-InducedOcular Side Effects and Ocular Toxicology in Bonn in May 1986 .The mission of the symposium and this book is to stimulate an interchange among academicians, clinicians

and drug manufacturers by presenting numerous advances in ocular toxicology. As an introduction to thissubject national and international recommendations and legal aspects concerning drug affairs are presented.The main part is concerned with clinical observations and experimental studies on drug-induced ocular side

effects and ocular toxicity. Drug kinetics and pharmacodynamics of often used ocular drugs are extensivelydiscussed. New methods for testing ocular toxicity and results of pilot studies are presented.The speciality of the lens as a target organ for toxic side effects and the increasing importance of cell culture

as an in vitro model for toxicity studies is pointed out in two separate chapters.This book makes a good survey of actual focal research points in ocular toxicology . Besides the high factual

content the book has also an impressive appearance due to numerous excellent ûgures and the high quality ofthe print. It would, however, be a pity if the price of this costly volume scares away many interested people andlimits the desirable distribution.

KltcucHl, H., TAKAMURA, T., Lstnl, M., ICHIHARA, T., ICew~uxe, Y. and S~wel, Y. (1987) Study on theeffectiveness of the yamakagashi (Rbabdophis tigrinus) antivenom. The Snake 19, 95 .

`PURIFIED' and freeze-dried anti-yamakagashi (Rirabdophis tigrinus) rabbit antivenom was used in the treatmentof two bites by the species . The results indicated that the hemorrhagic diathesis and prolonged bleeding timeimproved dramatically following the intravenous administration of one vial (10 ml) of the antivenom.

SHAYNE, C. G. (Ed.) Product Safety Evaluation Handbook, Drug and Chemical Toxicology Series, no . 6. NewYork : Marcel Dekker, 1988 .

ALL THOSE who are concerned with safety testing ofchemical products know that such tests have to be carefullyplanned, wnducted and analysed . This practical guide presents details of the procedures involved, beginningwith the formulation of the correct questions to be asked. Data on the conduct of studies, includingexperimental details and even notes on alternative experiments using fewer animals, are available in eachchapter. Of special interest is the chapter on `Available toxicology information sources and their use', outliningalso those aiteria that are helpful in conducting meaningful literature searches.

In conclusion, this book represents a practical guide for all the professionals who are in charge of ensuring thebiological safety of products.

ANDELMAN, J. B. and LTNDERHILL, D. W. (Eds) Health Effectsfrom Hazardous Waste Sites. Chelsea, MI : Lewis,1987 .

THIS Hoox provides a useful orientation on the nature, risks, methodologies and limitations in assessing possiblehuman health exposures and risks from hazardous waste sites . Besides the introducing chapter entitled'Evaluating health effects at hazardous waste sites : a review of the state-of-the-art, with recommendations forfuture research', all remaining chapters are based on presentations held at the Fourth Annual Symposium onEnvironmental Epidemiology in Pittsburgh in May 1983 . Thus, there is but one question left which we oftenencounter with congress proceedings : how did the state-of-the-art develop between the congress on which thepapers are based and the date when the book became available?

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K. GAUNERT

F. E. RUSSELL

J. ME~It

J. ME~t