HARVARD MEDICAL SCHOOL/HARVARD SCHOOL OF DENTAL … · The Cause, Course, and Cure of Nonalcoholic Fatty Liver Disease 2009 Session Chair Research Forum, AASLD Annual Meeting, Boston,

HARVARD MEDICAL SCHOOL/HARVARD SCHOOL OF DENTAL MEDICINE

CURRICULUM VITAE

Date Prepared: January 20, 2017

Name: Gyorgy Baffy, MD, PhD

Office Address: VA Boston Healthcare System, 150 S Huntington Ave, Rm A6-46, Boston, MA

02130

Home Address: 221 Reservoir Rd, Chestnut Hill, MA 02467

Work Phone: 857-364-4327

Work Email: [email protected]

Work FAX: 857-364-4179

Place of Birth: Miskolc, Hungary

Education

1980 MD

(Summa cum laude)

Medicine University of Debrecen Medical School,

Debrecen, Hungary

1994 PhD Medicine Hungarian Academy of Sciences, Budapest,

Hungary

Postdoctoral Training

9/80-12/85 Resident Internal Medicine University of Debrecen

1/86-4/88 Fellow Gastroenterology University of Debrecen

5/90-8/93 Research Fellow Biochemistry University of Pennsylvania, Philadelphia, PA

7/95-6/96 Fellow Gastroenterology University of Michigan, Ann Arbor, MI

7/96-6/98 Resident Internal Medicine St. Luke’s Medical Center, Cleveland, OH

7/98-6/01 Fellow Gastroenterology Brigham & Women’s Hospital, Boston, MA

7/98-6/01 Clinical Fellow Medicine Harvard Medical School, Boston, MA

Faculty Academic Appointments

9/85-5/92 Lecturer Medicine University of Debrecen

5/92-6/97 Assistant Professor Medicine University of Debrecen

7/01-9/07 Assistant Professor Medicine Brown Medical School, Providence, RI

10/07-4/08 Lecturer Medicine Harvard Medical School

5/08-10/14 Assistant Professor Medicine Harvard Medical School

7/10-5/16 Assistant Professor

(adjunct)

Medicine Boston University School of Medicine,

Boston, MA

9/10- Professor (honorary) Medicine University of Debrecen

7/12- Clinical Professor

Medicine Massachusetts College of Pharmacy and

Health Sciences, Boston, MA

10/14- Associate Professor Medicine Harvard Medical School

5/16- Associate Professor

(adjunct)

Medicine Boston University School of Medicine,

Boston, MA

mailto:[email protected]

2

Appointments at Hospitals/Affiliated Institutions

Past

5/88-6/97

Staff Physician Gastroenterology Department of Medicine I,

University of Debrecen

7/98-9/07 Staff Physician Ambulatory Care VA Boston Healthcare System, Boston, MA

7/01-9/07 Staff Physician Gastroenterology Rhode Island Hospital, Providence, RI

1/06-9/07 Staff Physician Gastroenterology Providence VA Medical Center, Providence, RI

Current 10/07- Staff Physician Gastroenterology VA Boston Healthcare System

4/08- Visiting Associate

Physician

Gastroenterology Brigham and Women’s Hospital

Other Professional Positions

1988 Clinical Visiting

Fellow

Gastroenterology Department of Gastroenterology,

Ruhr University, Bochum, Germany

2003-2007 Associate Member Pathobiology

Graduate Group

Brown University, Providence, RI

Major Administrative Leadership Positions

Local

2006-2007 Program Director Pathobiology Graduate Program, BIO285, Brown University

Introduction to Faculty Research

2006-2007 Co-Director Gastroenterology Section, Providence VA Medical Center

2007- Section Chief Gastroenterology Section, VA Boston Healthcare System

2016 Co-Director Workshop, HMS Academy Writing for Scholarship Interest Group

Barriers to Publication

Regional

2009 Course Director CME Postgraduate Course, VA Boston Healthcare System

Dysphagia: Evaluation and Management


Obesity and Nonalcoholic Fatty Liver Disease


Hepatocellular Carcinoma: Current Diagnosis and Management


Principles and Practice of New Imaging Techniques in

Gastroenterology

3

2011, 2012,

2013, 2014

Course Director CME Postgraduate Course, VA Boston Healthcare System

Update in GI and Hepatology for the Primary Care Provider

2014- Co-Chair Hepatitis C Management Improvement Project

Veterans Integrated Service Network 1 (VISN1), Bedford, MA


Diagnosis and Management of Digestive Diseases: A Primary Care

Perspective

2016 Co-Director VISN1 GI Summit

Challenges and Oportunities in Digestive Care and Research

National

2003 Course Director Workshop, HMAA Annual Meeting, Sarasota, FL

Hepatitis C

2004 Course Director Clinical Symposium, HMAA Annual Meeting, Sarasota, FL

Obesity and Colon Cancer

2007 Session Chair Research Forum, American Association for the Study of Liver

Diseases (AASLD) Annual Meeting, Boston, MA

Steatohepatitis: Experimental

2008 Organizer and

Program Director

Research Symposium, Digestive Disease Week, San Diego, CA

Inflammation and Adiposity in Gastrointestinal and Liver Disease

2008 Session Chair Research Forum, AASLD Annual Meeting, San Francisco, CA

Nonalcoholic Steatohepatitis: Experimental

2009 Organizer and

Program Director

Focused Study Group, AASLD Annual Meeting, Boston, MA

Cellular Targets of Lipotoxicity in Nonalcoholic Fatty Liver Disease


The Cause, Course, and Cure of Nonalcoholic Fatty Liver Disease

2009 Session Chair Research Forum, AASLD Annual Meeting, Boston, MA

Steatohepatitis: Experimental

2010 Program

Co-Director

Focused Study Group, AASLD Annual Meeting, Boston, MA

Genetics and Environment in the Progression of Nonalcoholic Fatty

Liver Disease


Hepatocellular Cancer: New Ways to Fight an Old Enemy

2010 Session Chair Research Forum, AASLD Annual Meeting, Boston, MA

Steatohepatitis: From Bench to Bedside

2012 Co-Moderator Research Symposium, Digestive Disease Week, San Diego, CA

Inflammation and Lipotoxicity in Nonalcoholic Steatohepatitis

4

Committee Service

Local

1975-1980 University Council University of Debrecen

Member

1980 Admissions

Committee


Member

2003-2005 PhD Thesis

Committee

Brown Medical School

Member

Advisor for Julia Xu, PhD, Thesis Title: Insulin Signaling in CNS Neurons and

Mechanisms of Insulin Signaling Regulation

2006-2007

Operative and

Invasive Procedures

Committee

Providence VA Medical Center

Member

2007- Fellowship

Committee

Division of Gastroenterology, Hepatology, and Endoscopy,

Brigham and Women’s Hospital

Member

2009- Fellowship

Admission

Committee



Member

2010-2013 Standing Committee Department of Continuing Education, Harvard Medical School

Member

2013- Committee on

Proposal Review

Department of Continuing Education, Harvard Medical School

Member

2014- Fellowship Education

Committee



Member

2014- Program Evaluation

Committee



Member

2014-2018 The Academy Academy Center for Teaching & Learning, Harvard Medical

School

Member

Regional

2010 PhD Thesis

Committee


Member

Outside Reader for Orkonthuya Tsedensodnom, PhD, Thesis Title: Identification and

Characterization of T Cell Factor-4 (Tcf-4) Isoforms of Wnt Signaling in Hepatocellular

Carcinoma (HCC)

Professional Societies

1995- American Society for Gastrointestinal Endoscopy (ASGE)

1995- Member

5

1996- American Gastroenterological Association (AGA)

1996- Member

2007-2009 Chair, Abstract Review Committee (Obesity: Basic: Regulation of

Food Intake, Satiety, Animal Models, Preclinical Trials)

2009- Fellow (AGAF)

2012- Member, AGA Academy of Educators

1997- AASLD

1997- Member

2006- Member and Chair, Abstract Review Committee (Steatohepatitis:

Experimental; Alcohol: Clinical and Experimental)

2007-2012 Member, Steatohepatitis Special Interest Group Steering Committee

2008-2010 Member, Basic Research Committee

2010- Member, Federal Agencies Liaison Committee

2014-

2017-2019

Fellow (FAASLD)

Member, Annual Meeting Education Committee

1997- American College of Physicians (ACP)

1997- Member

2014- Fellow (FACP)

1998- Massachusetts Medical Society

1998- Member

1999- HMAA

1999- Member

2003- Member, Annual Meeting Scientific Committee

2006-2010 Member, Board of Directors

2012-2014 President

2002- European Association for the Study of the Liver (EASL)

2002- Member

2010- Hungarian Society of Gastroenterology

2010- Honorary Member

2016- American College of Gastroenterology (ACG)

2016- Fellow (FACG)

Grant Review Activities

2004- NIDDK Special Emphasis Group ZDK1 GRB-N

2004, 2007, 2008, 2010, 2012, 2013

National Institutes of Health

(NIH)

Ad hoc member

6

2009 NIDDK Special Emphasis Group ZRG1 DKUS-A (58)

2009

NIH

Ad hoc member

2009 Burroughs-Wellcome Trust Intermediate Fellowship

Award

2009

Wellcome Trust

Ad hoc reviewer

2012 Hospital Clinical Research Program - PHRC 2012

2012

French National Cancer Institute

Ad hoc reviewer

2015,

2016

Fulbright Visiting Scholarship Program J William Fulbright Foreign

Scholarship Board

Ad hoc reviewer

Editorial Activities

Ad hoc Reviewer

Advances in Clinical Chemistry

Alcoholism: Clinical & Experimental Research

Alimentary Pharmacology and Therapeutics

American Journal of Gastroenterology

American Journal of Physiology/Gastrointestinal and Liver Physiology

Apoptosis

Biochemical Journal

Biochimica et Biophysica Acta – Molecular Cell Research

Bioscience Reports

BMJ Open Gastroenterology

Cancer

Cancer Research

Carcinogenesis

Cellular and Molecular Life Sciences

Chemistry & Biology

Digestive Diseases and Sciences

Expert Reviews in Gastroenterology & Hepatology

FASEB Journal

FEBS Letters

Gastroenterology

Hepatology

International Journal of Molecular Sciences

Journal of Biological Chemistry

Journal of Cellular Biochemistry

Journal of Clinical Gastroenterology

Journal of Gastrointestinal Cancer

Journal of Hepatology

Journal of Pediatric Gastroenterology and Nutrition

Lancet Gastroenterology and Hepatology

Lancet Oncology

Liver International

Metabolism: Clinical and Experimental

Molecular Cancer Therapeutics

7

Nature Medicine

New England Journal of Medicine

Pediatrics

PLoS One

World Journal of Gastroenterology

World Journal of Hepatology

Other Editorial Roles

2009-2012 Member, Editorial Board The Scientific World Journal

2009-2015 Member, Editorial Board World Journal of Gastrointestinal

Pathophysiology

2012-2015 Member, Editorial Board Clinical Gastroenterology and Hepatology

2012- Member, Editorial Board Journal of Clinical and Translational

Hepatology

2013 Topic Editor

Mechanisms of Oncogenesis in Fatty Liver

Disease

Frontiers in Oncology

2013 Lead Guest Editor

Special Issue: Nonalcoholic Fatty Liver

Disease

Gastroenterology Research and Practice

2013- Member, Editorial Board Journal of Hepatocellular Carcinoma

2014- Senior Editor Cancer Research Frontiers

Honors and Prizes

1980 Valedictorian University of Debrecen

School of Medicine

Academic

1990 Young Investigator

Scholarship (OMGE)

World Organization of

Gastroenterology,

Sydney, Australia

Research

1994 Rolf Madaus Prize Madaus Liver Foundation,

Cologne, Germany

Research

2004 Med Habil University of Debrecen

School of Medicine

Academic

2010 Géza Hetényi Award Hungarian Society of

Gastroenterology

Academic

2010 Brigham Leadership Program

(Cohort III)

Harvard Business School

(HBS), Boston, MA 2014 Fulbright US Scholar

Award

J William Fulbright Foreign

Scholarship Board

Academic/Teaching

2017 Pro Optimo Merito in

Gastroenterologia

Hungarian Society of

Gastroenterology

Academic

Report of Funded and Unfunded Projects

Funding Information

8

Past

1991-1996 Studies on Ca2+

signaling of rat hepatocytes with chronic alcoholic injury

NIH Fogarty International Center / F05TW004545

Role: PI

The main goal of this project was to characterize the role intracellular calcium in the

signal transduction pathways of EGF, HGF, and other growth factors in hepatocytes.

1993-1996 Growth factor Ca2+

signaling in alcoholic liver disease

NIH Fogarty International Center / R03TW000247

Role: Co-PI

The main goal of this grant was to fund a collaborative effort between the University of

Pennsylvania and University of Debrecen on hepatocellular calcium signaling

pathways.

1996-1999 Regulation and signaling of hepatocellular apoptosis

OTKA (Hungarian Scientific Research Fund)

Role: PI

The main goal of this grant was to explore the role of intracellular calcium partitioning

and signaling pathways in hepatocellular apoptosis.

2001-2006 Uncoupling protein-2 in the pathogenesis of steatohepatitis

NIDDK / K08DK061890

Role: PI

The main goal of this study was to characterize the biological role of UCP2 and identify

mechanisms by which it contributes to the development and progression of NAFLD.

2002-2006 Centers for Biomedical Research Excellence (COBRE) Theme A: Fetal proteins &

phenotypes in cancer: UCP2 expression in colon cancer

National Center for Research Resources (NCRR) / P20RR017695

Role: Project PI

The main goal of this project was to investigate the link between UCP2 and colon

cancer in transformed cell lines and in experimental paradigms including high-fat

feeding and azoxymethane-induced chemical carcinogenesis in UCP2 knockout mice.

2009-2013 Neoplastic yield of colonoscopy in the VA health care system

Veterans Affairs Office of Research and Development (VA-ORD) / I01HX000221

(PI: Thomas Imperiale)

Role: Co-Investigator

The main goal of this project was to measure how frequently and in whom colonoscopy

discovers cancer and significant pre-cancerous polyps by using refined data extraction

tools to analyze the electronic medical record from 18 VA medical centers.

9

2013-2014 VX11-950-116 An Open-Label, Phase 4 Study of Telaprevir, Peginterferon Alfa-2a

(Pegasys®), and Ribavirin (Copegus®) in Treatment-Experienced Black/African

American and Non-Black/African American Subjects With Genotype 1 Chronic

Hepatitis C Who Have Not Achieved a Sustained Viral Response With a Prior Course of

Interferon-Based Therapy (Sponsored by Vertex Pharmaceuticals, Inc.)

Study Director: Medical Monitor (Vertex Pharmaceuticals, Inc.)


The goal of this study was to evaluate the efficacy of telaprevir in combination with

Peginterferon alfa-2a (Peg-IFN) and Ribavirin (RBV) in treatment-experienced

Black/African American and non-Black/African American subjects with genotype 1

chronic hepatitis C.

2015-2016 Multicenter Study to Evaluate the Safety and Efficacy of Ombitasvir/ Paritaprevir/

Ritonavir and Dasabuvir with or without Ribavirin (RBV) in US Veterans with

Genotype 1 Chronic Hepatitis C Virus (HCV) Infection (TOPAZ-VA).

Role: Local Site Investigator

The goal of this study is to evaluate the safety and efficacy of ombitasvir/ paritaprevir/

ritonavir and dasabuvir with or without ribavirin in treatment-experienced US veterans

with genotype 1 chronic hepatitis C.

Current

2013- CSP #577 – Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality

From Colorectal Cancer (CONFIRM) (PI: Jason Dominitz and Douglas Robertson)

Role: Local Site Investigator

The main goal of this study is to perform a large, simple, multicenter, randomized,

parallel group trial directly comparing screening colonoscopy with annual fecal

immunochemistry test (FIT) screening in average risk individuals and determine whether

colonoscopy is superior to FIT in the prevention of colorectal cancer mortality measured

over 10 years.

2016- Optical spectroscopy in the management of colorectal neoplasia (PI: Satish K. Singh)


The main goal of this project is to determine the utility of various optical methods in

finding spectral biomarkers associated with field carcinogenesis in the colon and rectum

Current Unfunded Projects

2011- Nonalcoholic fatty liver disease in US veterans

Role: PI

The purpose of this study is to determine the prevalence of fatty liver among US veterans

and use biochemical and imaging biomarkers of increased risk for advanced liver disease.

2011- Hepatocellular cancer in nonalcoholic fatty liver disease

Role: PI

The main goal of this project is to analyze the contribution of nonalcoholic fatty liver

disease to the changing prevalence of HCC among US Veterans.

10

2011- Prediction of hepatocellular carcinoma by cytometric analysis

Role: PI

The main goal of this project is to identify preneoplastic changes in chronic hepatitis C

with known outcome of HCC and determine the utility of tissue-based cytometry

techniques in this analysis

Report of Local Teaching and Training

Teaching of Students in Courses

University of Debrecen, Hungary

1980-1990 Internal Medicine

3rd

to 5th

year medical students


One 2-hr seminar per week for 25 weeks

1982-1985 Introduction to Medicine

1st to 2

nd year nursing students

József Madzsar Nursing School, Debrecen,

Hungary

One 2-hr seminar per week for 25 weeks

1984-1995 Internal Medicine

3rd

to 5th



Two 2-hr lectures per week for 25 weeks

2012 Gastroenterology / Internal Medicine

4th

to 5th



Single 2-hr seminar

Brown University / Medical School

2001-2006 Gastroenterology /BIOMED351

3rd


Two 2-hr sessions per year

2002-2006 Introduction to Faculty Research / BIO285

1st year Pathobiology Program PhD students

One 3-hr session per year

2006-2007 Abdominal Physical Exam / BIOMED362

2nd


Two 3-hr sessions per year

University of Rhode Island

2002-2007 Pharmacotherapy

2nd

year pharmacy students

College of Pharmacy, Kingston, RI

One 2-hr lecture per year

Harvard Medical School

2003 Advanced Biomedical Sciences / PA514.0

3rd


Single 2-hr lecture

2008- Gastrointestinal Pathophysiology / HST-120

3rd


Three 2-hr sessions per year

2011 Patient-Doctor II Objective Structured

Clinical Examination (OSCE)

2nd


Single 4-hr session of teaching/evaluation

2014, 2015,

2016

Physiology and biochemistry of the liver

Gastrointestinal Pathophysiology / HST-120

3rd


Single 2-hr lecture

11

Formal Teaching of Residents, Clinical Fellows and Research Fellows

2002-2007 Abnormal liver function tests

1st to 3

rd year medicine residents

Rhode Island Hospital

One hour lecture per year

2005 Carcinoid tumors

1st to 3

rd year GI fellows


Single one hour lecture

2005-2007 Colorectal cancer screening

1st to 3

rd year GI fellows



2006 Nutrition and colorectal cancer

1st to 3

rd year GI fellows



2007 Mitochondria and cancer

1st to 3

rd year GI fellows



2008-2009 Chronic hepatitis B

1st to 3


VA Boston Healthcare System


2010- Nonalcoholic fatty liver disease

1st to 3




Clinical Supervisory and Training Responsibilities

2001-2007 Gastroenterology inpatient consult attending


Eight weeks per year

2001-2007 Gastrointestinal endoscopy preceptor for 1st

to 3rd

year gastroenterology fellows


Two days per month

2005-2007 Gastrointestinal endoscopy preceptor for 1st

to 3rd

year gastroenterology fellows of



Two days per week

2005-2007 Outpatient clinic preceptor for 1st to 4

th year

gastroenterology fellows of Rhode Island

Hospital


One day per week

2007- Gastrointestinal endoscopy preceptor for 1st

to 4th

year gastroenterology fellows of

Brigham and Women’s Hospital and Boston

Medical Center


One day per week

2007- Outpatient clinic preceptor for 1st to 4

th year

gastroenterology fellows of Brigham and

Women’s Hospital and Boston Medical

Center


One 4-hr session per week

12

2009- Gastroenterology preceptor for graduate

students in the physician assistant program

Massachusetts College of Pharmacy and

Health Sciences

One 4-hr session per week for 1 month/year

2012- Outpatient clinic preceptor for 1st to 3

rd year

gastroenterology fellows of Beth Israel

Deaconess Medical Center



Laboratory and Other Research Supervisory and Training Responsibilities

1976-1980 Graduate Laboratory Instructor

Department of Hygiene & Epidemiology,



2001-2007 Supervisor of post-doctoral research fellows

Liver Research Center, Brown Medical

School

Daily mentorship for 3 years

2005-2007 Supervisor of undergraduate students

Liver Research Center, Brown Medical

School

Daily mentorship for 2 years

Formally Supervised Trainees and Faculty

2002-2003 Horimoto Masayoshi, MD, PhD

Assistant Professor, Osaka University, Japan

First-authored 2 manuscripts

2002-2004 Peter Fülöp, MD, PhD

Assistant Professor, University of Debrecen

First-authored 2 manuscripts, co-authored 4 manuscripts, defended PhD thesis

2002-2007 Zoltán Derdák, MD

Research Assistant Professor, Brown Medical School

First-authored 4 manuscripts, promoted to faculty as Research Assistant Professor

2003-2004 Nola Monti, CRNA

North Providence, RI

Gained training in basic laboratory techniques including small animal experiments

2003-2005 Eric Berthiaume, MD

Clinical Assistant Professor, Brown Medical School

Gained training in molecular biology and presented poster at Digestive Disease Week

2004-2007 Anthony Sheets

Pre-doctoral MD-PhD Fellow, Tufts Medical School, Boston, MA

First-authored a manuscript

2005 Akshay Shah, MD

GI Practitioner, Peoria, AZ

Gained training in molecular biology and study design

13

Formal Teaching of Peers (CME and Other Continuing Education Courses)

Those presentations below sponsored by outside entities are so noted and the sponsor is identified.

2006 Grant writing workshop


Panelist

Providence, RI

2006 The emerging obesity and fatty liver epidemic

Update in Gastroenterology and Hepatology,

Rhode Island Hospital CME Course

Single lecture

Providence, RI

2005-2007 Nicholas Mark

Pulmonary Critical Care Fellow, University of Washington, Seattle, WA

Co-authored 2 manuscripts

2006-2007 Andrea Kassai, MD, PhD

Assistant Professor of Medicine, UMass Medical Center, Worcester, MA

Defended PhD thesis

2009-2010 Walter Chan, MD

Staff Gastroenterologist, Brigham and Women’s Hospital and Assistant Professor in

Medicine, Harvard Medical School

Supervised subspecialty continuity clinic and endoscopy training during GI fellowship

2009-2010 Marvin Ryou, MD

Staff Gastroenterologist, Brigham and Women’s Hospital, and Instructor in Medicine,



2010-2013 Michal Tomczak, MD

Staff Gastroenterologist, Brigham and Women’s Hospital, and Instructor in Medicine,



2011-2013 Raffi Karagozian, MD

Advanced Liver Fellow, Columbia College of Physicians and Surgeons, New York, NY

Mentoring clinical research in the field of NAFLD and hepatocellular cancer

2013-2014 Wasif Abidi, MD

Fellow in Gastroenterology, Brigham and Women’s Hospital

Supervising subspecialty continuity clinic and endoscopy training during GI fellowship

2014-2015 Saikiran Kilaru, MD

Resident in Medicine, Beth Israel Deaconess Medical Center

Mentoring clinical research in the field of early biomarkers of hepatocellular carcinoma

2014-2015 Edward Barnes, MD


Supervising subspecialty continuity clinic during GI fellowship

2015- Navin Kumar, MD


Supervising subspecialty continuity clinic and clinical innovation research project during GI

fellowship

2016- Taha Qazi, MD


Supervising subspecialty continuity clinic and endoscopy training during GI fellowship

14

2006 Complications and management of cirrhosis

Update in Gastroenterology and Hepatology,

Rhode Island Hospital CME Course

Single lecture

Providence, RI

2010, 2013,

2015

Nonalcoholic fatty liver disease

Brigham and Women’s Hospital/Harvard Medical School

GI Board Review Course

Single lecture

Boston, MA

(Sponsored by CMEinfo)

2010 Chronic hepatitis B

Intramural academic seminar


Single lecture

Boston, MA

2012 How to write and publish a scientific paper?

HMAA Summer Conference

Workshop Director

Balatonfüred, Hungary

2013 Colorectal cancer screening: Act in evolution

22nd

Educational Symposium of Spinal Cord Injury

Service, VA Boston Healthcare System

Single lecture

Boston, MA

2015 Alcoholic liver disease

Brigham and Women’s Hospital/Harvard Medical School

GI Board Review Course

Single lecture

Boston, MA

(Sponsored by CMEinfo)

Local Invited Presentations

No presentations below were sponsored by outside entities.

2000 Uncoupling protein-2 in the pathogenesis of steatohepatitis


Research seminar

2002 Nonalcoholic fatty liver disease

Department of Medicine, Rhode Island Hospital

Grand rounds

2002 UCP2 in the liver: Up and down, in and out

Liver Research Center, Rhode Island Hospital

Research seminar

2003 Uncoupling protein-2 and cancer bioenergetics

COBRE Cancer Center, Rhode Island Hospital

Single lecture

2004 Adaptation of tumor cells to oxidative stress


Single lecture

2005 Uncoupling protein-2 fitting the grand design: Evidence for

its role in cancer


Research seminar

2005 Origins of oxidative stress in obesity


Research seminar

2006 Uncoupling protein-2 and p53: Friends or foes?


Research seminar

2007 VA initiatives in colon cancer screening

Department of Medicine, Providence VA Medical Center

Grand rounds

2007 UCP2 in cancer: A case for chemoresistance


Research seminar

2007 UCP2 and the p53 response in cancer cells


Research seminar

15


Department of Medicine, VA Boston Healthcare System

Grand rounds

2008 Uncoupling protein-2: What is in a name?


Research seminar

2008 The Warburg effect


Research seminar

2009 The liver in obesity: Outcomes for a not quite innocent

bystander

Research Day, VA Boston Healthcare System

Research seminar

2009 Lipid-mediated mechanisms in NAFLD progression

Center for Engineering in Medicine and Surgical Services,

Massachusetts General Hospital

Research seminar

2009 Current concepts in the pathogenesis of NAFLD

Department of Pathology and Laboratory Medicine, VA

Boston Healthcare System

Grand rounds




Clinical seminar

2010 Mitochondrial UCP2: Promises and problems


Research seminar

2011 Colorectal cancer screening: Current status and future

expectations

Spinal Cord Injury Service, VA Boston Healthcare System

Grand rounds




Clinical seminar



Grand rounds

2015 Chronic hepatitis C: Pacing change


Grand rounds

2016 Innovation and turf wars in digestive surgery:

A medical perspective

Department of Surgery, VA Boston Healthcare System

Grand rounds

2016 Drug-induced liver injury



Clinical seminar

2016 Nonalcoholic fatty liver disease: Current status and

emerging trends

Department of Medicine, VA Boston Healthcare System

Grand Rounds

Report of Regional, National and International Invited Teaching and

Presentations Invited Presentations and Courses

Those presentations below sponsored by outside entities are so noted and the sponsor is identified.

Regional

16

2006 Cholestasis

Providence, RI

Clinical seminar

(Sponsored by Axcan

Pharma)

2006 Mitochondria and cancer: Evolutionary milestones

HMAA New England Chapter, Concord, MA

Research seminar

2006 Mitochondrial uncoupling and hypoxia-inducible factor in

cancer

Biocurrent Laboratory Seminar Series, Marine Biological

Laboratories, Woods Hole, MA

Research seminar

2006 Role of UCP2 in immune cell functions

University of Massachusetts, Worcester, MA

Research seminar

2009 NAFLD: Pathomechanism and progression

CME Course: Obesity and nonalcoholic fatty liver disease


Single lecture

2010 Pathophysiology of hepatocellular cancer

CME Course: Hepatocellular carcinoma


Single lecture

2011 Abnormal liver function tests: What is your plan?

CME Course: Update in Gastroenterology for the Primary

Care Provider


Single lecture

2011 Nonalcoholic fatty liver disease: Where are we and what is

ahead?

Boston Area NAFLD Research Group, Boston, MA

Research seminar


CME Course: Update in Hepatology for the Primary Care

Provider


Single lecture

2013 Current trends in the management of chronic hepatitis C


Care Provider


Single lecture

2013 Approach to the patient with fatty liver disease


Care Provider


Single lecture

2013, 2014 Current trends in the management of chronic hepatitis B


Care Provider


Single lecture

2014 Fatty liver disease: Spectrum, outcomes, comorbidities


Care Provider


Single lecture

17

2015 Hepatocellular carcinoma

CME Course: Diagnosis and Management of Digestive

Diseases: A Primary Care Perspective


Single lecture

2016 Screening and management of hepatocellular carcinoma

Challenges and Opportunities in Quality Improvement for

Digestive Care and Research

VISN1 New England GI Summit, Boston

Single lecture

National

2006 New treatment options for hepatitis B and C

American College of Physicians CME Program

Single lecture

Warwick, RI

2006 Abnormal liver function tests

American College of Physicians CME Program

Single lecture

Warwick, RI

2002 Insulin resistance and non-alcoholic fatty liver disease

HMAA Annual Meeting, Sarasota, FL

Plenary talk

2006 Mitochondrial bioenergetics in cancer


Plenary talk

2007 Colon cancer screening: Shifting strategies


Plenary talk

2008 UCP2 at the crossroads of energy metabolism,

inflammation and tumorigenesis

Digestive Disease Week, San Diego, CA

Single lecture

2008 Update on non-alcoholic fatty liver disease


Plenary talk

2009 Lipotoxicity in NAFLD: Liver targets and mechanisms


Plenary talk

2009 Role of Kupffer cells in steatohepatitis

Focused Study Group, AASLD Annual Meeting, San

Francisco, CA

Panelist

2010 Epidemiology and the burden of hepatocellular cancer


Plenary talk

2011 Colorectal cancer prevention and the future of

colonoscopy


Plenary talk

2012 Allostasis and personalized risk prediction in chronic

disease – Hans Selye Memorial Symposium,


Plenary talk

2013 Stress, chaos, and complexity: A new framework of

physiological adaptation – Symposium on Network

Biology and Network Medicine


Plenary talk


Nationwide VA Video Conference (SCAN-ECHO)

Veterans Health Administration

Single lecture

18

International

2005 Oxidative stress and cancer: Are uncoupling proteins on

the right or wrong side?

15th

Annual Meeting, Hungarian Free Radical Society,

Debrecen, Hungary

Plenary talk

2006 The biological functions of UCP2


Habilitation lecture

2002 NAFLD: Epidemic of the new millennium


Grand rounds

2003 Cirrhosis and its complications


Clinical seminar

2003 Neuroendocrine tumors


Clinical seminar

2004 The dual role of free radicals in tumor formation

ROS as signaling molecules and mediators of inflammation

(International Symposium), Providence, RI

Plenary talk

2008 Mitochondria and cancer: Prospects for novel therapeutic

targets

8th

International Conference of International Institute for

Anticancer Research, Kos, Greece

Single lecture

2008 Smoking and the digestive system

Anti-tobacco conference, Budapest, Hungary

Plenary talk

2010 NAFLD: 21st century perspectives

Hungarian Society of Gastroenterology, Annual Meeting,

Tihany, Hungary

State-of-the-art lecture

2011 Health care reform in the United States

Kazincbarcika Teaching Hospital, Hungary

Seminar

2012 The changing landscape of hepatocellular carcinoma

PhD Postgraduate Program in Epidemiology and Clinical

Epidemiology, University of Debrecen


2013 Nonalcoholic fatty liver disease: Societal impacts

20th

Annual Meeting of the Scientific Medical Student

Association, University of Medicine and Pharmacy of

Târgu Mures, Târgu Mures, Romania


2013 Physician career socialization in the US and Hungary

HMAA Summer Conference, Balatonfüred, Hungary

Panelist

2013 Collaboration and exchange through ethnic medical

organizations: An enduring mission

1st Central and Eastern European Regional Meeting of the

Association of Academic Health Centers International,

Budapest, Hungary

Plenary talk

2014 New perspectives and paradigm changes in hepatology

14th

GI Postgraduate Course, Semmelweis University,

Budapest, Hungary

Plenary talk

2014 Colorectal cancer screening: Lessons and perspectives

21st Annual Meeting of the Scientific Medical Student


19

Report of Clinical Activities and Innovations

Current Licensure and Certification

1985 Certified in Internal Medicine, Hungarian Board of Internal Medicine, Budapest,

Hungary

1989 Certified in Gastroenterology, Hungarian Board of Internal Medicine, Budapest, Hungary

1992 Indefinitely valid ECFMG Certificate

1999- Massachusetts Medical License

1998-2008 Certified in Internal Medicine, American Board of Internal Medicine

2000-2010 Certified in Gastroenterology, American Board of Internal Medicine

2010-2020 Recertified in Gastroenterology, American Board of Internal Medicine

Association, University of Medicine and Pharmacy of

Târgu Mures, Târgu Mures, Romania

2014 Comprehensive review of obesity and associated disorders

Fulbright US Teaching Scholar at the Medical and Health

Sciences Center of the University of Debrecen

Fifteen 2-hour seminars

(Full semester course)

2014 Chaos in adaptation: Understanding complex disease

Life Sciences Center Seminar Series, University of

Debrecen

Research seminar

2014 Colorectal cancer screening: Quo vadis?


Grand rounds

2014 Appetite regulation and weight control: An update

10th

Postgraduate Course in Endocrinology

Semmelweis University



University of Szeged, Hungary

Clinical seminar

2014 Physiological adaptation: A dynamic network view

University of Pécs, Hungary

Grand rounds

2015 Alcoholic liver disease: New developments

15th

GI Postgraduate Course, Semmelweis University

Plenary talk

2016 Pharmacotherapy in nonalcoholic fatty liver disease:

Advances and promises

16th

GI Postgraduate Course, Semmelweis University

Plenary talk

2017 Advances in the treatment of nonalcoholic fatty liver

disease

Hungarian Society of Gastroenterology, Annual Meeting,

Siófok, Hungary


20

Practice Activities

1980-1990

Ambulatory care

General medicine

Department of Medicine I


Two 4-hr sessions per week

1988-1990 Inpatient Attending Department of Medicine I


Eight months per year

1988-1990 Gastrointestinal

endoscopy



Four 4-hr sessions per week


endoscopy



Five 4-hr sessions per week

2001-2005 Hepatology outpatient

clinic

Division of Gastroenterology




endoscopy




2005-2007 Hepatology outpatient

clinic





endoscopy

Department of Medicine


Three 6-hr sessions per week

2007- Gastrointestinal

endoscopy

Section of Gastroenterology



2007- Gastroenterology

outpatient clinic




2007- Inpatient consult

attending



Six-to-ten weeks per year

Clinical Innovation

Implement electronic

documentation of GI procedures


(2008)

Spearheaded and directed the introduction of CP (Clinical

Procedures), a software package integrated with the comprehensive

VA electronic patient record system, to improve documentation of

scheduling, informed consent, reporting, and coding/billing for all

GI procedures.

Enhance efficiency of colorectal

cancer screening efforts


(2009)

Promoted innovative assignments to improve veterans compliance

with nationwide VA mandates, such as use of patient navigators

and “concierge” service to guide patients through bowel

preparation and colonoscopy

Incentives to improve adherence

with colonoscopy appointment


(2010)

Developed a program to evaluate how small financial incentives

such as cafeteria vouchers affect high no-show/cancellation rates

for colonoscopy scheduled in the outpatient endoscopy practice

21

Promote liver wellness and raise

awareness of NAFLD


(2010)

Supported by multiple funding from the VA Public Health

Strategic Health Care Group, initiated a program to improve and

preserve liver health with a focus on obesity-related fatty liver

disease that includes lifestyle guidance for veterans by using

professional society-issued educational brochures and a dedicated

liver clinic Specialty care collaborative in

hepatology among US veterans


(2012)

In response to a nationwide systems redesign VA initiative,

developed a 4P program to enhance liver wellness among US

veterans: preventive (emphasize the importance of lifestyle),

predictive (standardize evaluation of liver health and HCC

surveillance), personalized (assess individual risk of liver disease

progression), and participatory (involve liver patients in their own

care through telemedicine and online resources).

Smartphone app to assist US

Veterans with colonoscopy

preparations

(2016)

Supervised a clinical innovation project to develop a smartphone

app designed to assist US Veterans scheduled for screening

colonoscopy and improve bowel prep quality and adherence

resulting in improved endoscopy workflow and success rates at the

VA Boston Healthcare System.

Report of Education of Patients and Service to the Community No presentations below were sponsored by outside entities

Activities

1984-1990 Update in nutrition and dietetics

Two to three 1-hr lectures per year given to lay community at various venues in the city

of Debrecen, Hungary

2009 Colorectal cancer screening in the United States

Single 90-min seminar given to lay community at an urban outpatient healthcare center

in Budapest, Hungary

2010 Nonalcoholic fatty liver disease: How important is the diagnosis?

Single 90-min seminar given to lay community at an urban outpatient healthcare center

in Budapest, Hungary

2012 Nonalcoholic fatty liver: Anatomy of an ordinary disease

Science Club, Hungarian Society of Massachusetts

Single 2-hour seminar given to the lay community in Boston, MA

2016 Studying at Harvard University: Opportunities and choices

Harvard Club of Hungary: Back to Your School

Single 1-hour seminar at the Földes High School, Miskolc, Hungary

Educational Material for Patients and the Lay Community

No educational materials below were sponsored by outside entities

1984-1990 Seminars in Dietetics,

5 vols.

Patient education pamphlets Author

22

1988 Hyperlipoproteinemias:

Diagnosis and

Management

Patient education pamphlet Author and Editor

Report of Scholarship

Peer-Reviewed Publications in Print or Other Media

Research Investigations

1. Boján F, Baffy G, Fényi A. Studies on the carcinogenic effects of urethane. IV. Mechanism of lung

tumor inducing effect of urethane. Magy Onkol 1979; 23: 263-1.

2. Baffy G, Varga Z, Fóris G, Leövey A. Disturbed calcium-related processes of hepatocytes and

neutrophils in human alcoholic liver disease. Clin Biochem 1990; 23: 241-5.

3. Sápy P, Baffy G, Garami Z, Országh I. A long-term follow-up study of decompression type

operations in chronic pancreatitis. Magy Seb 1990; 43: 202-7.

4. Sápy P, Bakó G, Baffy G, Olvasztó S, Balázs G. A comparative study on Whipple-type and

pylorus-preserving pancreatoduodenectomies in chronic pancreatitis. Magy Seb 1990; 43: 286-93.

5. Baffy G, Sápy P, Olvasztó S. Pylorus-preserving pancreatoduodenectomy with

pancreatogastrostomy: clinical and endoscopic findings after a modified procedure. Magy Belorv

Arch 1990; 43: 88-95.

6. Reed JC, Talwar HS, Cuddy M, Baffy G, Williamson J, Rapp UR, Fisher GJ. Mitochondrial

protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp Cell Res 1991;

195: 277-83.

7. Yang L, Baffy G, Rhee SG, Manning D, Hansen CA, Williamson JR. Pertussis toxin-sensitive Gi

involvement in epidermal growth factor-induced signal transduction in rat hepatocytes. J Biol

Chem 1991; 266: 22451-8.

8. Baffy G, Yang L, Michalopoulos GK, Williamson JR. Hepatocyte growth factor induces calcium

mobilization and inositol phosphate formation in rat hepatocytes. J Cell Physiol 1992; 153: 332-9.

9. Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, Williamson JR. Epidermal growth factor-

mediated signaling of Gi-protein to activation of phospholipases in rat-cultured hepatocytes. J Biol

Chem 1993; 268: 3739-46.

10. Baffy G, Miyashita T, Williamson JR, Reed JC. Apoptosis induced by withdrawal of interleukin-

3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of

intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J Biol Chem 1993;

268: 6511-9.

23

11. Baffy G, Yang L, Wolf BA, Williamson JR. G protein specificity in signaling pathways that

mobilize calcium in the insulin-secreting -TC3 cells. Diabetes 1993; 42: 1878-82.

12. Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin

receptor in Chinese hamster lung fibroblasts. J Biol Chem 1994; 269: 8483-7.

13. Baffy G, Sharma K, Shi W, Ziyadeh FN, Williamson JR. Growth arrest of a murine mesangial

cell line by transforming growth factor 1 is associated with inhibition of mitogen-induced Ca2+

mobilization. Biochem Biophys Res Commun 1995; 210: 378-83.

14. Baffy G, Boyle JM. Association of Zollinger-Ellison syndrome with pancreatitis. Dig Dis Sci

2000; 45: 1531-4.

15. Jacobson BC, Strate L, Baffy G, Huang L, Mutinga M, Banks PA. The nature of after-hours

telephone medical practice by gastroenterology fellows. Am J Gastroenterol 2001; 96: 570-3.

16. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O,

Kim Y, Zheng XX, Wheeler M, Shulman GI, Chan C, Lowell BB. Uncoupling protein-2

negatively regulates insulin secretion and is a major link between obesity, -cell dysfunction and

type 2 diabetes. Cell 2001; 105: 745-55.

17. Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity-related fatty liver is unchanged in mice

deficient for mitochondrial uncoupling protein-2. Hepatology 2002; 35: 753-61.

18. Horimoto M, Fülöp P, Derdák Z, Wands JR, Baffy G. Uncoupling protein-2 deficiency promotes

oxidant stress and delays liver regeneration in mice. Hepatology 2004; 39: 386-92.

19. Horimoto M, Resnick MB, Konkin TA, Routhier J, Wands JR, Baffy G. Expression of uncoupling

protein-2 in human colon cancer. Clin Cancer Res 2004; 10: 6203-7.

20. Derdák Z, Fülöp P, Sabo E, Tavares R, Berthiaume EP, Resnick MB, Paragh G, Wands JR, Baffy

G. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-

B activation and oxidative stress. Carcinogenesis 2006; 27: 956-61.

21. *Fülöp P, *Derdák Z, Sheets A, Sabo E, Berthiaume E, Resnick M, Wands JR, Paragh G, Baffy G.

(*Equal contribution) Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals

importance of cell-specific UCP2 expression. Hepatology 2006; 44: 592-601.

22. Sheets AR, Fulop P, Derdak Z, Kassai A, Sabo E, Mark NM, Paragh G, Wands JR, Baffy G.

Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol

Gastrointest Liver Physiol 2008; 294: G1017-24.

23. Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling

protein-2 promotes chemoresistance in cancer cells. Cancer Res 2008; 68: 2813-9.

24

24. Tarnoki AD, Tarnoki DL, Bata

P, Littvay

L, Osztovits

J, Jermendy

G, Karlinger

K, Lannert

A,

Preda I, Kiss

RG, Molnar

AA, Garami

Z, Baffy

G, Berczi

V. Heritability of nonalcoholic fatty liver

disease and association with abnormal vascular parameters: A twin study. Liver Int 2012; 32:

1287-93.

25. Sun X, Han L, Seth P, Bian S, Linglin L, Csizmadia E, Junger WG, Schmelzle M, Usheva A,

Tapper E, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and

abnormal cellular metabolism promote development of hepatocellular carcinoma in Cd39/Entpd1

null mice. Hepatology 2013, 57: 205-16.

26. Tarnoki AD, Tarnoki DL, Bogl L, Medda E, Fagnani C, Nisticò L, Stazi M, Brescianini S,

Lucatelli P, Boatta E, Zini C, Fanelli F, Baracchini C, Meneghetti C, Osztovits J, Jermendy G,

Kiss R, Préda I, Karlinger K, Lannert A, Molnár A, Littvay L, Garami Z, Bérczi V, Pucci G, Baffy

G, Schillaci G, Pietiläinen K. Association of body mass index with arterial stiffness and blood

pressure components: a twin study. Atherosclerosis 2013, 229: 388-95.

27. Karagozian R, Baker E, Houranieh A, Leavitt D, Baffy G. Risk profile of hepatocellular

carcinoma reveals dichotomy among US veterans. J Gastrointest Cancer 2013, 44: 318-24.

28. Tarnoki AD, Tarnoki DL, Medda

E, Cotichini

R, Stazi

MA, Fagnani

C, Nisticò

L, Lucatelli

P,

Boatta E, Zini

C, Fanelli

F, Baracchini

C, Meneghetti

G, Schillaci

G, Osztovits

J, Jermendy

G, Kiss

RG, Préda I, Karlinger

K, Lannert

A, Metneki J, Molnar

AA, Garami

Z, Halasz

I, Berczi

V, Baffy

G. Bioelectrical impedance analysis of body composition in an international twin cohort. Obes Res

Clin Pract 2014, 8: e91-7.

29. Imler TD, Morea J, Kahi C, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy

G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A,

Smalley W, Imperiale TF. Multi-center colonoscopy quality measurement utilizing natural

language processing. Am J Gastroenterol 2015, 110: 543-52.

30. Tarnoki AD, Tarnoki DL, Littvay L, Garami Z, Molnar

AA, Berczi

V, Karlinger

K, Baffy

G.

Environmental factors responsible for variability of hepatic vein flow: a Doppler assessment in

healthy twins. Chin J Med 2016, 59: 33-8.

31. Rodriguez-Diaz E, Baffy G, Singh SK. Probe-based confocal laser endomicroscopy quantitative

morphometric markers associated with portal hypertension in duodenal mucosa. Liver Int, 2016,

36:223-31.

32. Karagozian R, Bhardwaj G, Wakefield D, Baffy G. Obesity paradox in advanced liver disease:

Obesity is associated with lower mortality in hospitalized patients with cirrhosis. Liver Int, 2016

36:1450-6.

Other Peer-Reviewed Publications

All publications in this section were peer-reviewed.

1. Baffy G, Várhelyi I, Halász I. Giant ovarian dermoid cyst mimicking bowel perforation. Orv Hetil

1988; 129: 1001-2.

25

2. Yang L, Baffy G, Rhee SG, Williamson JR. Epidermal growth factor-mediated signal transduction

in rat hepatocytes. In: Ross EM, Wirtz KWA, eds. Biological Signal Transduction. NATO ASI

Series, Vol. H 52. Berlin-Heidelberg: Springer-Verlag, 1991; pp. 511-25.

3. Baffy G. Apoptosis and the control of liver growth. Magy Belorv Arch 1994; 47: 309-16.

4. Baffy G, Strate LL, Krinsky, ML. The black esophagus. Image of the month. Gastroenterology

2000; 118: 252.

5. Várvölgyi C, Balogh Z, Bodnár Z, Eke E, Baffy G. Small-unit colonoscopy and quality assurance

(Letter). Endoscopy 2000; 32: 504.

6. Baffy G. Acute liver disease. In: Leppert PC and Peipert J., eds. Primary Care for Women, 2nd ed.

Philadelphia: Lippincott William & Wilkins, 2004; pp. 426-33.

7. Baffy G. Uncoupling protein-2 and non-alcoholic fatty liver disease. Front Biosci 2005; 10: 2082-

96.

8. Hyatt P, Resnick MB, Habr F, Baffy G. Image of the month: Brunner’s gland hamartoma. Clin

Gastroenterol Hepatol 2006; 4: A26.

9. Derdak Z, Garcia TA, Baffy G. Detection of uncoupling protein-2 as a mitochondrial modulator of

apoptosis. Methods Mol Biol 2009; 559: 205-17.

10. Baffy, G. Kupffer cells in nonalcoholic fatty liver disease: The emerging view. J Hepatol 2009;

51: 212-23.

11. Okpara N, Aswad B, Baffy G. Eosinophilic colitis. World J Gastroenterol 2009; 15: 2975-9.

12. Baffy G, Tarnoki A, Tarnoki D, Baffy N. Colorectal cancer screening: Lessons from the American

experience. Magy Radiol, 2009; 83: 164-73.

13. Baffy G. Uncoupling protein-2 and cancer. Mitochondrion 2010; 10: 243-52.

14. Baffy G. Negative outcomes for intraoperative blood transfusion in patients with advanced

cirrhosis: Post hoc ergo propter hoc? (Letter). Clin Gastroenterol Hepatol 2010; 8: 996.

15. Baffy G, Derdak Z, Robson, SC. Mitochondrial recoupling: A novel therapeutic strategy in

cancer? Br J Cancer 2011; 105: 469-74.

16. Baffy G. Hepatocellular carcinoma in type 2 diabetes: More than meets the eye (Editorial). Am J

Gastroenterol 2012; 107: 53-5.

17. Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in nonalcoholic fatty liver disease:

An emerging menace. J Hepatol 2012; 56: 1384-91.

26

18. Baffy G. Allostasis in nonalcoholic fatty liver disease: Implications for risk assessment. Dig Dis

Sci 2013, 58: 302-8.

19. Tarnoki AD, Tarnoki, DL, Baffy G. Heritability of nonalcoholic fatty liver disease: Evidence and

implications. In: Leon V. Berhardt, ed. Metabolic Disorders: Clinical Aspects, Potential

Complications and Dietary Management. Hauppauge, New York: Nova Science Publishers, 2013;

pp. 237-248.

20. Tarnoki AD, Tarnoki DL, Karlinger K, Berczi V, Baffy G. Nonalcoholic fatty liver disease:

Implications for the radiologist. Magy Radiol 2013, 4: 1-9.

21. Baffy G. Hepatocellular carcinoma in nonalcoholic fatty liver disease: Epidemiology,

pathogenesis, and prevention. J Clin Translat Hepatol 2013, 1: 131-7.

22. Baffy G. The impact of network medicine in gastroenterology and hepatology. Clin Gastroenterol

Hepatol 2013, 11: 1240-4.

23. Karagozian R, Derdak Z, Baffy G. Obesity-associated mechanisms of hepatocarcinogenesis.

Metabolism 2014, 63: 607-17.

24. Baffy G, Loscalzo J. Complexity and network dynamics in physiological adaptation: An integrated

view. Physiol Behav 2014, 131: 49-56.

25. Tarnoki AD, Tarnoki DL, Baffy

G. Response to the letter entitled ‘Bioimpedance analysis—The

shortcomings’ (Letter). Obes Res Clin Pract 2014, 8: e511-2.

26. Baffy G, Derdak Z. Obesity and hepatocellular carcinoma: Anatomy of a relationship. Magy

Belorv Arch 2014, 67: 5-16.

27. Kilaru S, Baffy G. Metformin and hepatocellular carcinoma. J Symptoms Signs 2015, 4:15-24.

28. Baffy G. Decoding multifocal hepatocellular carcinoma: An opportune pursuit (Editorial). J

Hepatobil Surg Nutr 2015, 4: 206-10.

29. Baffy G, Krisko T. Alcoholic liver disease. In: Greenberger NJ, Blumberg RS, and Burakoff R,

eds. Current Diagnosis & Treatment. Gastroenterology, Hepatology, & Endoscopy. 3rd ed. New

York: McGraw Hill, 2015. pp. 528-35.

30. Baffy G. The human microbiota and digestive cancer. Magy Belorv Arch 2015, 63: 46-55.

31. Krisko T, Baffy G. Alcoholic liver disease. In: Burakoff R, editor. Scientific American

Gastroenterology, Hepatology, and Endoscopy. Hamilton (ON): Decker Intellectual Properties;

September 2015. doi: 10.2310/7900.5450 (September 10, 2015).

32. Baffy G. MicroRNAs in nonalcoholic fatty liver disease. J Clin Med 2015, 4:1977-88.

27

33. Baffy G. Novel strategies in the pharmacotherapy of nonalcoholic fatty liver disease. Centr Eur J

Gastroenterol Hepatol, 2016, 2:54-60.

34. Baffy G. Hepatocellular carcinoma in nonalcoholic fatty liver disease. In: Abel T and Lengyel G,

eds. Nonalcoholic fatty liver disease. Bentham Science Publishers, 2017, in press.

35. Baffy G. General adaptation syndrome. In: Zeigler-Hill V and Shackelford TK, eds. Encyclopedia

of Personality and Individual Differences, Berlin-Heidelberg: Springer-Verlag, 2017, in press.

36. Baffy G. Mitochondrial uncoupling in cancer cells: Liabilities and opportunities. Biochim Biophys

Acta, 2017, http://dx.doi.org/10.1016/j.bbabio.2017.01.005.

37. Baffy G, Fisichella PM. Gastrointestinal surgery and endoscopy: Trends in competition and

collaboration, Clin Gastroenterol Hepatol, 2017, in revision.

Professional Educational Materials or Reports, in print or other media

1. Baffy G. Basic diagnostics in upper panendoscopy (Videotape, 36 min), University Medical School

of Debrecen, Debrecen, Hungary, 1989.

2. Baffy G. Teaching medicine abroad: A Fulbright experience. Harvard Insight, 2015; 5 (9).

3. Baffy G. Alma mater revisited: Teaching medicine as a Fulbright scholar. Harvard Medical Student

Review, 2015; 3: 40-4.

Theses

1. Baffy G. Growth factors in liver regeneration: studies on the intracellular calcium signaling and

homeostasis (PhD Thesis). University of Pennsylvania, Philadelphia, and Hungarian Academy of

Sciences, Budapest, Hungary, 1995; 113 pp.

2. Baffy G. Biology and pathobiology of mitochondrial uncoupling protein-2 (Doctor of Academy

Dissertation). Hungarian Academy of Sciences, Budapest, Hungary, 2012; 79 pp.

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

1. Baffy G, Varga Z, Fóris G, Leövey A. Disturbed calcium-related processes of hepatocytes and

neutrophils in human alcoholic liver disease. World Congresses of Gastroenterology, Sydney,

Australia, 1990 (2nd

Prize of Young Investigator Award).

2. Fülöp P, Resnick M, Wands JR, Baffy G. UCP2 affects fasting-induced steatosis and metabolic

parameters in lean and obese mice. Hepatology 2002; 36: 486A (AASLD President’s Choice

Poster)

28

3. Baffy G, Fülöp P, Derdak Z, Wands JR, Horimoto M. Modulation of oxidant production and cell

cycle activity by uncoupling protein-2 in regenerating mouse liver. 12th

Falk Liver Week, Freiburg,

Germany, 2003 (3rd

Best Poster Prize).

4. Monti NA, Fülöp P, Resnick M, Wands JR, Baffy G. Uncoupling protein-2 modulates crypt cell

apoptosis rate in the colon of mice fed with high-fat diet. Gastroenterology 2003; 124 (4 Suppl 1):

A261 (Poster of Distinction)

5. Fülöp P, Resnick M, Wands JR, Baffy G. Fas-mediated liver injury in ob/ob mice is attenuated in

the absence of uncoupling protein-2. Gastroenterology 2003; 124 (4 Suppl 1): A757 (Poster of

Distinction)

6. Sheets A, Derdák Z, Sabo E, Fülöp P, Wands JR, Baffy G. Fasting-induced changes in hepatic lipid

metabolism are blunted in UCP2 deficiency and point to a novel physiological role. Hepatology

2006; 44 (4 Suppl 1): 482A (Presidential Poster of Distinction)

7. Rodriguez-Diaz E, Baffy G, Pedrosa MC, Singh SK. Microvascular assessment of portal

hypertension using probe-based confocal laser endomicroscopy. Hepatology 2011; 54 (4 Suppl):

950A.

8. Karagozian R, Baker E, Baffy G. Hepatocellular carcinoma among US veterans: Recent trends and

implications. Digestive Disease Week, San Diego, CA, 2012, Su2046.

9. Rodriguez-Diaz E, Baffy G, Pedrosa MC, Taunk P, Dai S-C, Singh SK. Assessment of portal

hypertensive enteropathy (PHE) using probe-based confocal laser endomicroscopy (pCLE).

Digestive Disease Week, San Diego, CA, 2012, Sa1840.

10. Shao B, Wakefield D, Baffy G, Karagozian R: Obesity Paradox: Obesity is associated with lower

risk of inpatient mortality in patients with cirrhosis, Nationwide Inpatient Sample, Hepatology

2015; 62: 1( Suppl): 927A.

11. Dominitz J, Robertson D, on behalf of CONFIRM Investigators. Impact of mailing time and

season on fecal immunochemical test (FIT) positivity. Digestive Disease Week, San Diego, CA,

2016.

Narrative Report

I earned my MD degree at the University of Debrecen in Hungary, where I then completed specialty

training in internal medicine and gastroenterology (GI). I earned my PhD for the research I conducted

as a Fogarty Fellow at the University of Pennsylvania. After additional training in US medicine and

gastroenterology, I joined the faculty of Brown Medical School and Rhode Island Hospital. In 2007, I

was appointed chief of gastroenterology at the VA Boston Healthcare System (VABHS), where my

current professional efforts primarily include clinical service, administrative, and leadership activities,

with the remaining time devoted to teaching and research.

29

Area of Excellence: Clinical Expertise and Innovation. Patient care is an essential and rewarding

part of my work. Since 2007, I have been active clinically at the VA in GI endoscopy and the GI

outpatient clinic, and as an inpatient consult attending. I have also introduced clinical innovations

involving the electronic medical record, patient navigators to improve compliance, incentives to

decrease the colonoscopy cancellation rate, and lifestyle guidance to preserve liver health. My clinical

and procedural skills benefit from the initial 10 years of academic practice that I did in Hungary.

In the past 25 years, I have focused on various aspects of fatty liver disease. As an NIH Fogarty

fellow, I analyzed calcium-mediated growth factor signaling in liver cells. As a GI fellow, I studied the

role of uncoupling protein-2 (UCP2) in fatty liver at HMS and expanded this work to bioenergetics

and metabolic reprogramming in digestive cancers at Brown. My current work includes various

projects aimed at nonalcoholic fatty liver disease (NAFLD), a prevalent condition that may predict

morbidities with profound societal implications. We study the risk of hepatocellular carcinoma in

veterans. We utilize concepts of network medicine to predict disease trajectories in NAFLD and to

improve cost effectiveness of cancer surveillance. Using an international twin cohort, we study

heritability of NAFLD and associated cardiovascular disease. I have written several reviews and

concept papers, and organized regional and national symposia and workshops on issues of the

pathophysiology and clinical management of fatty liver. My goal is to establish a center of

excellence for obesity-associated liver diseases at VABHS.

Teaching and Education: I have taught medical students, residents, and GI fellows from the

beginning of my academic career and continue to do so at HMS and VA-affiliated GI training

programs. I have also mentored several postdoctoral fellows, undergraduates, and PhD candidates now

successful in their own research careers. I have organized many local, regional, and national CME

events. Since 2009, I have been the program director of a highly successful postgraduate series at

VABHS on a variety of major topics in gastroenterology and hepatology, providing an important

educational opportunity for the Veterans Integrated Service Network 1 in New England. As the

recipient of a Fulbright US Scholar Fellowship, I recently worked at the University of Debrecen

School of Medicine in Hungary. This program was sponsored by the US Department of State Bureau

of Educational and Cultural Affairs and allowed me to teach an accredited course on obesity and

associated disorders. The course consisted of 15 two-hour seminars in the English language program

over a total of 8 weeks during the first semester of the 2014/15 academic year.

Significant Supporting Activities: Investigation: Dual NIH funding supported my research at

Brown, where my group made fundamental observations on the pathobiology of mitochondrial

uncoupling proteins in hepatocytes and cancer cells. I serve as the local site investigator for the

extensive VA Cooperative Studies Program (CSP 577 - CONFIRM) on the impact of colonoscopy vs.

fecal immunochemical testing on colorectal cancer mortality. My additional investigations currently

focus on early biomarkers of hepatocellular carcinoma at VABHS, BWH, and Beth Israel Deaconess

Medical Center.

Administrative and Institutional Service: I have been a member of various committees in the HMS

Department of Continuing Education and completed a 1-year leadership program at HBS. The unique

academic environment of my current position as section chief provides me with major opportunities to

advance the cause of digestive disease care and prevention.

Documents

HARVARD MEDICAL SCHOOL/HARVARD SCHOOL OF DENTAL … · The Cause, Course, and Cure of Nonalcoholic Fatty Liver Disease 2009 Session Chair Research Forum, AASLD Annual Meeting, Boston,