Hangover HellHangover Hell

By: By: Names of Team Names of Team

MembersMembers

Introduction Introduction

Chemistry of a hangoverChemistry of a hangover Ways to prevent a hangoverWays to prevent a hangover What you should do when you What you should do when you

come across a much hated come across a much hated hangoverhangover

Alcohol is a Organic Alcohol is a Organic CompoundCompound

Ethyl alcohol (ethanol) Ethyl alcohol (ethanol) CHCH33CHCH22OHOH Alcohol found in beveragesAlcohol found in beverages Main method for production is Main method for production is

fermentationfermentation Miscible in water (homogeneous mixture)Miscible in water (homogeneous mixture) Low molecular weight (easy to cross Low molecular weight (easy to cross

blood-brain membrane)blood-brain membrane)

Alcohol in the BodyAlcohol in the Body

Approx. 20% is absorbed in stomachApprox. 20% is absorbed in stomach Approx. 80% in small intestineApprox. 80% in small intestine Absorbed into bloodstreamAbsorbed into bloodstream Gastric emptying is most important factor Gastric emptying is most important factor

of absorption rateof absorption rate Food, no matter what kind, affects this Food, no matter what kind, affects this

raterate Also strenuous physical activityAlso strenuous physical activity

Alcohol is CatalyzedAlcohol is Catalyzed

Alcohol reaches bloodstream where it is Alcohol reaches bloodstream where it is catalyzed.catalyzed.

CHCH33CHCH22OH + NADOH + NAD++ CH CH33CHO + NADH + HCHO + NADH + H++

Product is AcetaldehydeProduct is Acetaldehyde Toxic, Causes liver damage, creates nausea, and Toxic, Causes liver damage, creates nausea, and

dilates bloodvessels in head to create headachedilates bloodvessels in head to create headache

Finally Oxidized to Acetic AcidFinally Oxidized to Acetic Acid Normal to humansNormal to humans

Variety of Factors also Variety of Factors also ContributeContribute

Alcohol is diuretic (makes you Alcohol is diuretic (makes you urinate) which causes dehydrationurinate) which causes dehydration

Metabolic byproductsMetabolic byproducts Various other organic molecules in Various other organic molecules in

drinksdrinks Some drinks also contain methanolSome drinks also contain methanol

MethanolMethanol

Found in fruit based beverages such as wine Found in fruit based beverages such as wine and brandyand brandy

Catalyzed to Formaldehyde rather than Catalyzed to Formaldehyde rather than AcetaldehydeAcetaldehyde

Then converted to Formic AcidThen converted to Formic Acid FormaldehydeFormaldehyde

Excessive amounts cause deathExcessive amounts cause death May lead to blindnessMay lead to blindness Causes much worse hangoverCauses much worse hangover

Ways to Prevent The Hated Ways to Prevent The Hated HangoverHangover 1. Don’t mix different types of 1. Don’t mix different types of

drinks. drinks. 2. If possible, drink “clear” 2. If possible, drink “clear”

alcohols. alcohols. 3. Ladies, don’t try to be a hero and 3. Ladies, don’t try to be a hero and

compete with the guys. compete with the guys. 4. Dark colored alcohols have small 4. Dark colored alcohols have small

quantities of other toxic substances quantities of other toxic substances or congeners that are created or congeners that are created during the fermentation process. during the fermentation process.

5. Drink plenty of water. 5. Drink plenty of water.

What Do You Do When You What Do You Do When You Have A Hangover?Have A Hangover? 1. Don’t try to drink more.1. Don’t try to drink more. 2. Again, this can’t be stressed 2. Again, this can’t be stressed

enough……drink plenty of water or enough……drink plenty of water or other fluids but avoid orange or other fluids but avoid orange or grapefruit juice.grapefruit juice.

3. Eat light, nutritious foods for most 3. Eat light, nutritious foods for most of the day after and stay away from of the day after and stay away from greasy, fatty foods. greasy, fatty foods.

4. Avoid the sauna to relieve a 4. Avoid the sauna to relieve a hangover. hangover.

What to do……continuedWhat to do……continued

5. A drug called Liv52, an herbal 5. A drug called Liv52, an herbal remedy (Himalaya Drug Co., India) has remedy (Himalaya Drug Co., India) has been demonstrated to decrease the been demonstrated to decrease the symptoms of a hangover. symptoms of a hangover.

6. Over the counter medications like 6. Over the counter medications like aspirin and ibuprofen are frequently aspirin and ibuprofen are frequently used by hangover sufferers. used by hangover sufferers.

7. Just lay low for the day.7. Just lay low for the day.

Bibliography PageBibliography Page

Boggen, Bill. Alcohol Chemistry. 2003. Kennesaw State Boggen, Bill. Alcohol Chemistry. 2003. Kennesaw State University. University. 28 Mar. 2005 <http://chemcases.com>. 28 Mar. 2005 <http://chemcases.com>.

Karpman, Benjamin. The Hangover. Springfield: Karpman, Benjamin. The Hangover. Springfield: Charles C Thomas, Charles C Thomas, 1957. 7-526. 1957. 7-526.

Minocha, Anil. Alcohol Hangover. 1999. 28 Mar. 2005 Minocha, Anil. Alcohol Hangover. 1999. 28 Mar. 2005 <http://diagnosishealth.com>. <http://diagnosishealth.com>.

Questions or Comments?Questions or Comments?