Herbal Extract Company of Australia The See full monograph for referencing, available at: www.herbalextracts.com.au Version: aug16/01 Pau d'arco (Handroanthus spp.) Clinical Summary Traditional and Empirical Use The inner bark of pau d’arco has been used as a cure-all by the native Americans of Brazil, northern Argentina, Paraguay, Bolivia and Peru for thousands of years.Traditionally it is ingested as a decoction with indications, that may pre-date the Incas (13th Century), as an analgesic, anti-inflammatory, astringent, antineoplastic and diuretic for treating inflammatory diseases, lupus, cancer, diabetes, prostatitis, blood coagulation, fungal, bacterial and viral infections including syphilis, candidiasis, malaria, fevers, trypanosomiasis (the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus Trypanosoma), and gastrointestinal problems including constipation and peptic ulcers. Constituents The major active constituents are 16 quinones, containing both naphthoquinones and anthraquinones. It is considered very rare to have both these groups of quinones occurring in the same plant and the synergy between them may account for several of the remarkable properties of pau d’arco. Other constituents include tabebuin, lapachenole, quercetin, o- and p- hydroxybenzoic acids, benzaldehyde derivatives, cyclopentene dialdehyde, flavonoids, iridoid glycosides, lignan glycosides, isocoumarin glycosides, phenylethanoid glycosides and phenolic glycosides. Actions Antitumour, antioxidant, antimicrobial, antiviral, anti-parasitic, anti-inflammatory, anticoagulant, anti-platelet; analgesic; anti- proliferative, anti-depressant, anti-obesity. Indications • Adjunct for Cancer • Inflammatory diseases including lupus, psoriasis, cardiovascular disease • Infections, candidiasis, trichomonas vaginalis, herpes simplex virus, influenza, helicobacter pylori • Parasitic diseases such as schistosomiasis • Cervicitis and cervico-vaginitis • Oedema Toxicity No evidence of toxicity in humans despite the widespread use of the crude herb. Use in Pregnancy Contraindicated. Contraindications and cautions Caution should be used in patients with blood disorders, those who are having surgery, taking anticoagulant or antiplatelet medications or supplements, due theoretically to an increased risk of bleeding. Avoid with known allergy/hypersensitivity to pau d'arco, its constituents, or members of the Bignoniaceae family. Drug interactions Avoid in those who are taking anticoagulant, or antiplatelet medications or supplements, as pau d'arco may theoretically increase the risk of bleeding. The potential for preparations of pau d’arco to interact with other medicines administered concurrently, particularly those with similar or opposing effects, should be considered. Administration and dosage Liquid extract 1:1 45% alcohol: 10 to 20mL weekly

(Handroanthus spp.) Clinical Summary · 2017-06-05 · • Cervicitis and cervico-vaginitis • Oedema Toxicity No evidence of toxicity in humans despite the widespread use of the

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Page 1: (Handroanthus spp.) Clinical Summary · 2017-06-05 · • Cervicitis and cervico-vaginitis • Oedema Toxicity No evidence of toxicity in humans despite the widespread use of the

Herbal ExtractCompany of Australia

TheSee full monograph for referencing, available at:www.herbalextracts.com.auVersion: aug16/01

Pau d'arco(Handroanthus spp.)

Clinical SummaryTraditional and Empirical UseThe inner bark of pau d’arco has been used as a cure-all by the native Americans of Brazil, northern Argentina, Paraguay, Bolivia and Peru for thousands of years.Traditionally it is ingested as a decoction with indications, that may pre-date the Incas (13th Century), as an analgesic, anti-infl ammatory, astringent, antineoplastic and diuretic for treating infl ammatory diseases, lupus, cancer, diabetes, prostatitis, blood coagulation, fungal, bacterial and viral infections including syphilis, candidiasis, malaria, fevers, trypanosomiasis (the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus Trypanosoma), and gastrointestinal problems including constipation and peptic ulcers.

ConstituentsThe major active constituents are 16 quinones, containing both naphthoquinones and anthraquinones. It is considered very rare to have both these groups of quinones occurring in the same plant and the synergy between them may account for several of the remarkable properties of pau d’arco. Other constituents include tabebuin, lapachenole, quercetin, o- and p- hydroxybenzoic acids, benzaldehyde derivatives, cyclopentene dialdehyde, fl avonoids, iridoid glycosides, lignan glycosides, isocoumarin glycosides, phenylethanoid glycosides and phenolic glycosides.

ActionsAntitumour, antioxidant, antimicrobial, antiviral, anti-parasitic, anti-infl ammatory, anticoagulant, anti-platelet; analgesic; anti-proliferative, anti-depressant, anti-obesity.

Indications• Adjunct for Cancer• Infl ammatory diseases including lupus, psoriasis, cardiovascular disease• Infections, candidiasis, trichomonas vaginalis, herpes simplex virus, infl uenza, helicobacter pylori• Parasitic diseases such as schistosomiasis• Cervicitis and cervico-vaginitis• Oedema

ToxicityNo evidence of toxicity in humans despite the widespread use of the crude herb.

Use in PregnancyContraindicated.

Contraindications and cautionsCaution should be used in patients with blood disorders, those who are having surgery, taking anticoagulant or antiplatelet medications or supplements, due theoretically to an increased risk of bleeding. Avoid with known allergy/hypersensitivity to pau d'arco, its constituents, or members of the Bignoniaceae family.

Drug interactionsAvoid in those who are taking anticoagulant, or antiplatelet medications or supplements, as pau d'arco may theoretically increase the risk of bleeding. The potential for preparations of pau d’arco to interact with other medicines administered concurrently, particularly those with similar or opposing eff ects, should be considered.

Administration and dosageLiquid extract 1:1 45% alcohol: 10 to 20mL weekly