REINITA ARLIN S.KED030.08.202

FAKULTAS KEDOKTERAN UNIVERSITAS TRISAKTI

Kepaniteraan Klinik Departemen Ilmu Kesehatan AnakRSUD Kota Bekasi

Etiologi

• Coxsackievirus A5, A7, A9, A10, A16, B1, B2, B3, B5, echovirus, enterovirus 71, etc.

• Un-enveloped, 7400 nukleotida.11,12

Coxsackievirus

Group Group IV (+)ssRNA

Famili Pikornaviridae

Genus Enterovirus (non polio)

Species Human enterovirus A, B

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8 th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62Morag A, Pearay LO. Enterovirus. In : Behrman RE, Kliegman, Arvin, editors. Nelson Textbook of Pediatrics. Vol.2. Terjemahan Oleh : Wahab AS. Jakarta: EGC; 2000. p. 1077-78Mancini AJ, Ayelet SA. Other Viral Diseases. In: Bolognia JL et al, editors. Dermatology. 3rd Ed. Edinburgh: Elsevier Saunders; 2012. p. 1345-48http://en.wikipedia.org/wiki/Coxsackievirus

Patogenesis

Thomas J. Hand-foot-and-mouth disease – An Overview. e-Journal of the Indian Society of Teledermatolog. 2009; 3 (4) : p. 1-4

Manifestasi Klinis

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8 th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62Habif TP. Clinical Dermatology 5th Ed. Edinburg: Mosby; 2009

Manifestasi Klinis

Vesikel “football-shaped” pada telapak kaki penderita HFMD5Vesikel pada telapak tangan pasien HFMD13

Ulserasi pada lidah yang merupakan salah satu lesi oral HFMD5

Vesikel dan eritem pada lidah pasien HFMD5

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8 th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62Starling JC. Virus Infection. In: Burn T et al, editors. Rook’s Textbook of Dermatology. 8th Ed. Massachusetts: Blackwell Publishing; 2010. p. 25.72-3

Pemeriksaan Penunjang

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8 th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62Thomas J. Hand-foot-and-mouth disease – An Overview. e-Journal of the Indian Society of Teledermatolog. 2009; 3 (4) : p. 1-4Wolff K, Richard AJ. Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology. 6 th Ed. New York: The McGraw Hills, Inc.; 2009. p. 803-4Sarma N. Hand, foot, and mouth disease: Current scenario and Indian Perspective. Indian J Dermatol Venereol Leprol 2013; 79: 165-75

Pemeriksaan Penunjang

A). Positive immunostaining of EV71 antigens in neuron and neuronal process. Original magnification, X158. B). Positive immunostaining of EV71 antigens in necrotic area. Original magnification, X158. C). An array of picornavirus particles in a neuron (electron micrograph).

Diagnosis Banding

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62

Komplikasi

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62

Tatalaksana

Pencegahan

Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8 th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62Centers for Disease Control and Prevention. Hand, Foot, and Mouth Disease : Prevention and Treatment. Available from: http://www.cdc.gov

Prognosis

Ooi, MH et al. Clinical Features, Diagnosis, and Management of Enterovirus 71. Lancet Neurology 2010; 9: 1097-1105Ahmed AM et al. Viral Disease. In: Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine. 8th Ed. New York: The McGraw Hills, Inc.; 2012. p. 2360-62