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Hanahan & Weinberg:
The hallmarks of cancer. Cell 100:57-70, 2000
ONCOGENE ACTIVATION
ONCOGENE ACTIVATION
TUMOR SUPPRESSOR INACTIVATION
p53
TUMOR SUPPRESSOR INACTIVATION
Locus 9p21
TUMOR SUPPRESSOR INACTIVATION
Protein-protein interactions
TUMOR SUPPRESSOR INACTIVATION
Cellula normale
Cellula tumorale
PTEN
INIBITORI DI mTOR
effetti lievi
attività PI3K/Akt/mTOR
attività PI3K/Akt/mTORPTEN
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 1 Examples of oncogene addiction: studies in mice
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 2 Examples of oncogene addiction: studies in human cancer cell lines
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 3 Clinical evidence of oncogene addiction
Cellula normale
Cellula tumorale
Rb
Rb
attività E2F
espressione gene A
espressione gene B
espressione gene topoisomerasi II
espressione gene C
VELENI DELLA TOPO II
SOPRAVVIVENZA
blocco attività E2F
% B inhibition % B inhibition
INIBIT GENE EXPRESSION
INIBIT PROTEIN FUNCTION
AS-ODN siRNA mAbs Small molecule inhibitors