H1N1 Vaccine Deployment and Vaccination update

H1N1 Pandemic Vaccine Deployment and Vaccination update 2 |

Outline

  Donor Commitments

  Vaccine Prequalification

  Country Preparedness

  Vaccine Deliveries

  Vaccine utilization and coverage

  Some lessons learned

H1N1 Pandemic Vaccine Deployment and Vaccination update 3 |

Vaccine Deliveries, by Donor

Norway, 1% Belgium, 2% CSL, 2% Switzerland,

2%

Italy, 3%

UK, 4%

Australia, 5%

Sanofi Pasteur, 14%

France, 15% USA, 21%

GSK, 31%

H1N1 Pandemic Vaccine Deployment and Vaccination update 4 |

Donor Commitments: Finances

0

10

20

30

40

50

60

70

USD

, mill

ions

Pledged Committed

H1N1 Pandemic Vaccine Deployment and Vaccination update 5 |

Donor Commitments: Vaccines

0

50

100

150

200

250

Mill

ions

of d

oses

Pledged Committed  Note:    Not  all  commi,ed  vaccine  became  immediately  available  for  delivery    

H1N1 Pandemic Vaccine Deployment and Vaccination update 6 |

Vaccine Prequalification

30/09/2005 30/10/2005 30/11/2005 30/12/2005 30/01/2006 01/03/2006 01/04/2006 01/05/2006 01/06/2006 01/07/2006 01/08/2006 31/08/2006 01/10/2006

0   1   2   3   4   5   6   7   8   9   10   11  Cumula&ve  number  of  vaccines  

Pandemic  Influenza  A  (H1N1)  vaccines  prequalified  by  WHO  

PrequalificaBon  date   Submission  date  

October  2010  September  2010  

August  2010  July  2010  June  2010  May  2010  April  2010  

March  2010  February  2010  January  2010  

December  2009  November  2009  October  2009  

 

H1N1 Pandemic Vaccine Deployment and Vaccination update 7 |

Recipient Country Preparation: Summary

0

5

10

15

20

25

30

35

40

Number of countries fulfilling pre-supply requirements

Letter of Intent Letter Agreement National Deployment Plan

07  Jan.  2010:    First  vaccine  delivery  

H1N1 Pandemic Vaccine Deployment and Vaccination update 8 |

Vaccine Deliveries, monthly

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

0

5

10

15

20

25

Vacc

ine

dose

s

Num

ber o

f del

iver

ies

Deliveries Volume delivered

15  April  2010:  Icelandic  volcano  disrupts  shipment  

H1N1 Pandemic Vaccine Deployment and Vaccination update 9 |

H1N1 Pandemic Vaccine Deployment and Vaccination update 10 |

H1N1 Vaccine Utilization and Coverage by Region

  Overall vaccination coverage in entire population in countries received vaccine from WHO: 6%

  Overall vaccination coverage in entire population at global level (exclude data from EUR countries under VENICE survey): 12 %

•  Planned target population group as defined by country which is not necessary represent actual target population in the country

•  ** Only data from 6 WHO eligible countries

Vaccine Coverage Vaccine Utilization

Region by general population by H1N1 target population*

Average Range Average Range Average Range

4% 0.4 - 11% 65% 4-110% 61% 2-100% AFRO

24% 0.1- 48% 94% 1-115% 64% 10 -100% AMRO

0.6% 0 -8% 6% 0-47% 15% 0 – 82% EMRO

4% 0.01 -19% n/a n/a 57% 0.2% - 95% EURO**

7% 3 - 7% 72% 25 - 74% 73% 25 - 77% SEARO

8% 0.4 - 87% 64% 39 -100% 53% 6-100% WPRO

H1N1 Pandemic Vaccine Deployment and Vaccination update 11 |

% Vaccine Coverage by H1N1 target group population and entire population in African Region (n = 21)

0 10 20 30 40 50 60 70 80 90 100

MauritiusMauritania

Sierra LeoneEquatorial Guinea

South AfricaMadagasgar

SeychellesLesotho

CongoCameroon

Sao Tome PrincipéKenya

ZimbabweNamibiaEthiopia

NigerGambiaGuineaLiberia

Central AfricanTogo

Source: H1N1 Pandemic Vaccine Deployment and Vaccination survey and termination reports

%

Mean: coverage by H1N1 target population : 65% Mean: coverage by entire population : 4%

Vaccination coverage rate per H1N1 target population Vaccination coverage rate per entire population

H1N1 Pandemic Vaccine Deployment and Vaccination update 12 |

%Vaccine Coverage by H1N1 target group population and entire population in American Region (n = 30)

0 10 20 30 40 50 60 70 80 90 100

BelizeGrenada

BahamasBarbadosBermuda

USATrinidad and Tobago

TurksPeru

UruguayMontserrat

PanamaCosta Rica

MexicoBrazil

EcaudorColombiaArgentina

SurinameNicaragua

GuyanaHonduras

ChileBolivia

ParaguayCuba

GuatemalaEl Salvador

Source: H1N1 Pandemic Vaccine Deployment and Vaccination survey and regional report

%

Mean: coverage by H1N1 target population= 94%

Mean: coverage by entire population = 24%

Vaccination coverage by H1N1 target group population Vaccination coverage rate per entire country population

H1N1 Pandemic Vaccine Deployment and Vaccination update 13 |

%Vaccine Coverage by H1N1 target group population and entire population in Eastern Mediterranean Region (n = 18)

Coverage is 0.0% for Pakistan, Somalia and Sudan

H1N1 Pandemic Vaccine Deployment and Vaccination update 14 |

%Vaccine Utilization and Coverage by entire population in European

Region (n = 6: only countries receiving vaccine from WHO)

0 10 20 30 40 50 60 70 80 90 100

Kosovo

Georgia

Azerbaijan

Tajikistan

Moldova

Armenia

Source: H1N1 Pandemic Vaccine Deployment and Vaccination survey and regional report

%

Vaccination coverage by entire population

Mean: Vaccine utilization = 57% Mean: coverage by entire population = 4%

Utilization rate: countries received WHO donated vaccine

H1N1 Pandemic Vaccine Deployment and Vaccination update 15 |

%Vaccine Coverage by H1N1 target group population and

entire population in South East Asia Region (n = 7)

0 10 20 30 40 50 60 70 80 90 100

Thailand

Bhutan

Maldives

Timor Leste

Sri Lanka

DPRK

Bangladesh

Source: H1N1 Pandemic Vaccine Deployment and Vaccination survey, and regional vaccination report

%

Vaccination coverage by H1N1 target group population

Vaccination coverage by entire population

Mean: coverage by entire population = 6%

H1N1 Pandemic Vaccine Deployment and Vaccination update 16 |

%Vaccine Coverage by H1N1 target group population and entire population in Western Pacific Region (n=26)

0 10 20 30 40 50 60 70 80 90 100

New ZealandNew Caledonia

MalaysiaChinaPalauJapan

Brunei DarussalumMarshall IslandsRepublic Korea

PhilippinesNiue

Papau New GuineaLao PDR

TuvaluSolomon Islands

MongoliaCook Islands

TongaCambodia

TokelauFiji

NauruSamoaKiribati

Vanautu

Source: WPRO H1N1 Pandemic Vaccine Deployment and Vaccination Monthly Update: February 2011, Country H1N1 vaccination termination reports

%

Mean: coverage by H1N1 target population= 64% Mean: coverage by entire population = 8%

Vaccination coverage by H1N1 target group population Vaccination coverage by entire population

H1N1 Pandemic Vaccine Deployment and Vaccination update 17 |

% H1N1 Vaccination Uptake by H1N1 Target Group*

Children Persons with

underlying Conditions

Pregnant women Health care workers Region

% Uptake* Country %Uptake* Country %Uptake* Country % Uptake* Country

96% 11/17 66% 14/17 48% 17/17 84% 17/17 AFRO

n/a n/a 119% 18/23 67% 23/23 100% 23/23 AMRO

2% 4/6 21% 5/6 7% 4/6 52% 6/6 EMRO

61% 1/6 67% 3/6 42% 4/6 62% 6/6 EURO**

42% 5/6 73% 6/6 86% 6/6 95% 6/6 SEARO

89% 5/9 85% 8/9 63% 9/9 86% 9/9 WPRO

• * Uptake = doses administered in each target group per planned H1N1 target group population which may not be actual target population

• **Data from countries receiving donated vaccine from WHO

H1N1 Pandemic Vaccine Deployment and Vaccination update 18 |

Main Operational Lessons Learned

 Country plans must be tailored to specific contextual issues.

 Maintaining global and country communication channels is critical.

 Countries suggested more emphasis on social mobilization and communication.

 Global operational readiness and training needed as well as country readiness.

H1N1 vaccination – public announcement in Tonga

H1N1 Pandemic Vaccine Deployment and Vaccination update 19 |

Main Operational Lessons Learned

  Legal framework of agreements should be maintained.

  A harmonized regulatory process across recipient countries could be useful.

 Cold chain capacity, global and country, may not be sufficient for future emergencies.

  Bundling of ancillary equipment remains crucial.

H1N1 vaccination – vaccine off load in Abuja, Nigeria

H1N1 Pandemic Vaccine Deployment and Vaccination update 20 |

THANK YOU