Guidelines to Prevent Guidelines to Prevent Central Line-Associated Central Line-Associated Blood Stream InfectionsBlood Stream Infections

Why do I need to Why do I need to complete this orientation?complete this orientation?

• Problem – Vascular access device-associated infections increase

morbidity, mortality, hospital length of stay, and costs. – Education of health care workers decreases healthcare-

associated infections.

• Intervention– Mandatory course to achieve standardization of infection

control practices during central vascular access device (C-VAD) insertion.

Why do I need to Why do I need to complete this orientation? (cont.)complete this orientation? (cont.)

*Sherertz, et al. Ann Intern Med. 2000;132(8):641-648

• Outcome– Education in another center achieved a 28 percent

relative reduction in central line infections and saved $800,000. *

– Since implementing this orientation, that center’s central line-associated related blood stream infection (CLABSI) rates have decreased below the national average.

Statistics for CLABSIsStatistics for CLABSIs

• 90 percent of all blood stream infections are associated with C-VADs.

• 400,000 CLABSIs occur each year in the United States.

• CLABSIs are —

– Associated with increased morbidity

– Associated with mortality rates of 10 percent to 20 percent

– Associated with prolonged hospitalization (mean of 7 days)

and increase in medical costs >$28,000

National Nosocomial Infection National Nosocomial Infection Surveillance RatesSurveillance Rates

• In 2003, National Nosocomial Infection Surveillance from the Centers for Disease Control & Prevention reported the number of CLABSIs per 1,000 catheter days based on nationwide intensive care unit (ICU) surveillance.

• Table 1 compares ICUs from one academic medical center to national benchmark CLABSI rates.

CLABSI Rates CLABSI Rates per 1,000 Catheter Daysper 1,000 Catheter Days

 

NHSN 90th Percentile

NHSN 50th Percentile

Pre-VAD Training

Post-VAD Training

SICU 9.1 5.3 6.7 0.6

PICU 11.9 7.7 5.5 5.4

CVICU 4.9 2.8 7.6 2.7

MICU 9.8 6.1 7.8 3.3

CCU 7.9 4.6 5.0 1.2

NCCU 8.3 4.9 6.6 3.7

OncICU 9.3 4.7 N/A 1.6

Risk Factors for CLABSIRisk Factors for CLABSI

• Site of insertion — Subclavian vein poses less risk than internal jugular or femoral vein.*

• Multiple lumen catheters —– Increased tissue trauma predisposes to CLABSI– More manipulation and contamination of multiple ports/hubs

• Total parenteral nutrition and/or lipids

• Low nurse to patient ratio

*Merrer, et al. JAMA. 2001;286:700-7

Risk Factors for CLABSIs Risk Factors for CLABSIs (cont.)(cont.)

• Infection elsewhere (remote, i.e., urinary tract infection or wound) — secondary source

• Colonization of catheter with organisms

• IV catheterization longer than 72 hours

• Inexperience of personnel inserting the C-VAD

• Use of stopcocks

Process of Process of Catheter-Related Infections Catheter-Related Infections

Five Evidence-Based Steps to Five Evidence-Based Steps to Prevent CLABSIPrevent CLABSI

1. Use appropriate hand hygiene.2. Use chlorhexidine for skin preparation.3. Use full-barrier precautions during central

venous catheter insertion.4. Avoid using the femoral vein for catheters in

adult patients.5. Remove unnecessary catheters.

Hand HygieneHand Hygiene

Wash hands with soap and water or use a waterless hand sanitizer —

– Before and after invasive procedures

– Between patients

– After removing gloves

– Before eating

– After using the bathroom

– If contamination is suspected

Hand Hygiene Works!Hand Hygiene Works!

Year Author SettingComparison

GroupResults

1982 Maki ICU (U.S.) Crossover ↓ Nosocomial Infection

1984 Massanari ICU (U.S.) Crossover ↓ Nosocomial Infection

2000 PittetTeaching Hospital,

SwitzerlandObservational

↓ Nosocomial Infection↓ MRSA Rates

Waterless Hand Hygiene StepsWaterless Hand Hygiene Steps

• Coat all surfaces of your hands thoroughly with waterless hand sanitizer, including palms, in between fingers, under fingernails, backs of hands, and around wrists.

• Rub your hands briskly until they feel comfortably dry.

• It takes about 15 seconds, and no water or towels are needed.

Hand Washing StepsHand Washing Steps

1. Wet hands.2. Obtain soap.3. Lather for 10 to 15

seconds.4. Rinse hands.5. Turn off faucet handles

with paper towel.

C-VAD Site SelectionC-VAD Site Selection

• Use the subclavian site unless medically contraindicated (e.g., patient has an anatomic deformity, coagulopathy, or has renal disease that may require dialysis).

C-VAD Site Selection:C-VAD Site Selection:Special ConsiderationsSpecial Considerations

• For patients on hemodialysis, the National Kidney Foundation’s 2000 guidelines recommended against the use of the subclavian vein for any VAD unless use of the internal jugular vein is absolutely contraindicated. This is due to the risk of subclavian vein stenosis.

• If the internal jugular vein is chosen, use the right side to reduce the risk of noninfectious complications.

C-VAD Line Selection C-VAD Line Selection

• Use a single lumen C-VAD, unless multiple lumens are absolutely necessary.

• Consider a tunneled or implanted C-VAD for

patients requiring long-term access (>30 days) or a PICC or cuffed C-VAD for patients requiring therapy for >1 week.

• Evaluate the need for C-VAD daily.– Remove it when not needed or change to a single lumen

C-VAD when possible.

Aseptic Technique: GoalsAseptic Technique: Goals

• Remove transient organisms and soil from the skin.

• Reduce the number of resident microbial flora and inhibit their rebound growth.

• Create a sterile working surface that acts as a barrier between the insertion site and any possible source of contamination.

Aseptic TechniqueAseptic Technique

• Prepare skin with antiseptic/detergentchlorhexidine 2 percent in 70 percent isopropyl alcohol.

• Pinch the wings on the “ChloraPrep” applicator to pop the ampule. Hold the applicator down to allow the solution to saturate the pad. Press the sponge against skin and apply chlorhexidine solution using a back-and-forth friction scrub for at least 30 seconds. Do not wipe or blot.

• Allow the antiseptic solution time to dry completely before puncturing the site. This may take 2 minutes.

Evidence Supporting Chlorhexidine Evidence Supporting Chlorhexidine Use: Skin Prep−Meta AnalysisUse: Skin Prep−Meta Analysis

Pooled RR for BSI

Ann Intern Med. 2002;136:792-801

Maximal Barriers Required Maximal Barriers Required for C-VAD Insertionfor C-VAD Insertion

• Use face mask, cap, and sterile gloves.

• Wear a sterile gown with neck snaps and wrap-around ties properly secured.

• Instruct anyone assisting you to wear the same barriers.

• Cover the patient entirely with a large sterile drape.

Maximal Barrier Precautions Maximal Barrier Precautions Decrease CLABSI InfectionsDecrease CLABSI Infections

Author Design Catheter TypeOR for

Infection Without MBR

Mermel/1990Prospective,

cross-sectionalSwan-Ganz 2.2 (p<0.03)

Raad/1994Prospective, randomized

Central 6.3 (p<0.03)

• OR = odds ratio• MBR = maximal barrier precautions. Inserter washes hands and

wears mask, cap, sterile gown, and sterile gloves. Patient’s head and body are covered with a large, sterile drape.

Caveats: Catheter InsertionCaveats: Catheter Insertion

• IV antimicrobial prophylaxis does not reduce CLABSI.*

• Insertion of C-VADs through open techniques/cut down increases the risk of CLABSI.

• Adequate room is needed to perform the procedure without risk of contamination.

*Ranson. J Hosp Infect. 1990;15(1):95-102.

Post Insertion: C-VAD CarePost Insertion: C-VAD Care

• Antimicrobial ointments do not reduce the incidence of CLABSI.

• A sterile dressing should be applied to the insertion site before the sterile barriers are removed.

• Transparent dressings are preferred to allow visualization of the site. However, if the insertion site is oozing, apply a gauze dressing instead of a transparent dressing.

• When the C-VAD dressing becomes damp, loosened, or soiled or after lifting the dressing to inspect the site, replace the dressing.

Replacing C-VADsReplacing C-VADs• Lines should be removed as soon as possible.

• Routine C-VAD guidewire exchange or site rotation is not recommended.*

• Guidewire exchange is acceptable for replacing a malfunctioning catheter or downsizing a pulmonary artery catheter to a central venous catheter.

• Patients who clearly have a CLABSI should not undergo a guidewire exchange.

• Selected patients with suspected blood stream infections and limited venous access may have their catheter exchanged over a guidewire and the catheter tip should be cultured. Before handling the new catheter, switch to a new set of sterile gloves.

*Eyer, et al. Crit Care Med. 1990;18(10):1073-9 .

Suspected C-VAD InfectionsSuspected C-VAD Infections

• Remove the C-VAD in a patient with proven CLABSI (i.e., blood culture positive for a recognized pathogen with no identified secondary source).

• If a blood stream infection is only suspected, the C-VAD is not known to be the source, or the C-VAD cannot be removed, clinical judgment is necessary. Extensive, evidence-based guidelines exist for the diagnosis and treatment of catheter-related infections.*

*Mermel, et al. Clin Infect Dis. 2001;32(9):1249-72.

• Draw two sets of blood cultures from a patient with new episode of suspected C-VAD infection, preferably both sets peripherally.

• It is not always necessary to remove the C-VAD in a mildly ill patient with unexplained fever.

• If the catheter is the suspected source of the infection, it can be changed over a wire and cultured. If the catheter culture grows 15 colony forming units of organisms, remove it and place at a different site.

• Tailor antimicrobial therapy to the individual patient based on severity of illness, suspected pathogen, and presence of complicating factors.

Suspected C-VAD Infections Suspected C-VAD Infections (cont.)(cont.)

C-VAD Line Cultures: C-VAD Line Cultures: IndicationsIndications

• The utility of catheter cultures is controversial; nonetheless, proper technique is imperative to evaluate the data.

• The catheter tip may be submitted for semiquantitative culture if there is clinical suspicion of CLABSI.

• Routinely removed catheters should not be sent for culture.

C-VAD Line Cultures: MethodC-VAD Line Cultures: Method

• Remove all dressings and cap off all hubs/ports then paint the site with antiseptic solution and include within the sterile field.

• Remove C-VAD en bloc. Under no circumstance should catheters be cut prior to removal.

• Remove the catheter aseptically, avoiding contact with the patient’s skin and catheter tray.

• Use sterile scissors (not the scalpel used to cut the C-VAD sutures) to cut a 5 cm segment, including the tip, and place it in a culture container.

• A catheter culture yield of 15 colony forming unit, accompanied by signs and/or symptoms of infection is consistent with a catheter-related infection.

• Do not give antibiotics based on a positive catheter culture only. Evaluate the clinical picture.

C-VAD Line Cultures: C-VAD Line Cultures: InterpretationInterpretation

Blood CulturesBlood Cultures

• Patients with a new episode of suspected catheter-related infection should have two sets of peripheral blood samples drawn for culture.

• In rare instances where access for peripheral blood draws is limited, one set may be drawn from the line and one set may be drawn percutaneously.

Peripheral Blood Cultures: Peripheral Blood Cultures: MethodMethod

• Don sterile gloves and observe standard precautions.

• Apply chlorhexidine 2 percent in 70 percent isopropyl alcohol (ChloraPrep Frepp) using a back-and-forth friction rub for at least 30 seconds over a 5 cm area.

• Allow the solution time to dry completely before puncturing the skin.

• Do not touch the venipuncture site after skin prep except with sterile gloves.

• Insert the needle into the vein and withdraw 20 cc of blood (adults).

• Distribute the blood evenly between two culture bottles (10 cc per bottle), taking care not to inject air into the anaerobic bottle.

• Always send a second set of blood cultures from a separate venipuncture site.

Arterial Line: Site Selection Arterial Line: Site Selection

• Radial artery is the preferred site.

• Dorsalis pedis is an alternative site.

• Femoral sites have higher infection rates and risk of thrombosis.

• Brachial/maxillary sites are a last resort because of the lack of collateral circulation.

Arterial Lines: Aseptic Arterial Lines: Aseptic TechniqueTechnique

• As with C-VADs, always:

– Clean your hands with soap and water or waterless hand cleaner.

– Maintain standard precautions.

– Perform thorough skin preparation.

– Use barrier protection.

Arterial Lines: BarriersArterial Lines: Barriers

• For radial or dorsalis pedis sites, create a generous sterile working surface using sterile drapes. Wear sterile gloves and a mask with face shield.

• Femoral or axillary arterial catheters may increase the risk of infection and require maximum barriers as with C-VADs, including mask, sterile gloves, sterile gown, and large sterile drape.

Special ThanksSpecial Thanks

Sean Berenholtz, M.D.

Roy Brower, M.D.

Raphe Consunji, M.D.

Sara Cosgrove, M.D.

Pamela Lipsett, M.D.

Trish Perl, M.D.

Peter Pronovost, M.D.

Lisa Cooper, R.N.