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H PP G S 96 L
96-well filter plates (2, 6, 20, or 50 µL)
H PP G S 96 L
Miniaturized prepacked columns (50, 200, and 600 µL)
H PP G S 96 L
Bottles of chromatography resins
H PP G S 96 L
Prepacked columns (1 and 5 mL)
H PP G S 96 L
Prepacked columns (4.7 mL with 10 cm bed height)
H PP G S 96 L
Single-use membranes
Single-use, prepacked columns ≥ 1 L
Product name PreDictor plates
PreDictor RoboColumn™ units
Bulk pack HiTrap™ columns HiScreen™ columns
ReadyToProcess adsorbers
ReadyToProcess columns
Application High-throughput screening
High-throughput process development
Batch purification and self-packing
Process development, screening
Method optimization
Process development, clinical manufacturing
Clinical manufacturing
Format guide – For ordering information, visit gelifesciences.com
Guide to modern BioProcess™ chromatography resins
gelifesciences.comGE, the GE Monogram, ÄKTA, BioProcess, Capto, HiTrap, HiScale, HiScreen, MabSelect, MabSelect SuRe, MabSelect Xtra, PreDictor, and ReadyToProcess are trademarks of General Electric Company.RoboColumn is a trademark of Repligen GmbH. All other third-party trademarks are the property of their respective owners. © 2016–2018 General Electric Company. GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, SwedenFor local office contact information, visit gelifesciences.com/contact.KA5602281118PO 29231394 AB
Capto Core 700
Capto Core 400
LambdaFabSelect
MabSelect SuRe™ LX
MabSelect SuRe pcc
Fragment containing
kappa light chain
Fragment containing
lambda light chain
A�nity for metal ions
Albumin/ NAD+
enzymes
Cation exchanger
For plasma proteins
Batch processes
Continuous processes
MabSelect Xtra™
MabSelect™
High titers
Low to medium titers
First choice
Limited number of
cycles
Long lifetime/
easy cleaning
Capto Heparin
VIISelect
VIIISelect
IXSelect
Capto Chelating
Capto Blue
Antithrombin III
Factor IX
Blood coagulation
factors
Capture
Capto S
ReadyToProcess™ Adsorber S*
Capto Q
Capto DEAE
PreDictor™ AIEX Screening
Capto S ImpAct
Capto SP ImpRes
Capto Q ImpRes
Capto Q ImpRes
Capto Q
Capto SP ImpRes
Capto S ImpAct
Capto S
ReadyToProcess Adsorber Q*
ReadyToProcess Adsorber S*
ReadyToProcess Adsorber Q*
Anion exchanger
Cation exchanger
Capto Q XP
Intermediate puri�cation
PolishingAnion exchanger
Screen di�erent
IEX resins
Bind/elute mode
Flow-through mode
Weak ion exchanger(when selectivityis unsatisfactory
with Capto Q)
Strongion exchanger
Intermediate puri�cation.
Screen di�erent
HIC resins
Capture
Polishing.Screen
di�erent HIC resins
Intermediate puri�cation
Polishing
Capto Butyl
Capto Butyl ImpRes
Capto Butyl
Capto Phenyl
Capto Phenyl
Capto Phenyl ImpRes
Capto Butyl ImpRes
ReadyToProcess Adsorber Phen*
Capto Phenyl ImpRes
Capto PlasmidSelect
Capto Octyl
PreDictor HIC Screening Low Hydrophobicity
PreDictor Screening High Hydrophobicity
PreDictor Capto HIC Screening
Optimal HIC resin for target protein is
known
Optimal HIC resin for target protein is
known
Bind/elute mode
Flow- through
mode
Capture
Bind/elutemode
Flow- through
mode
Screen di�erent
MM resins
Capto MMC
Capto adhere ImpRes
Capto adhere
Capto adhere ImpRes
Capto MMC ImpRes
Capto MMC ImpRes
Capto MMC
CaptureCapto AVB
KappaSelect
PreDictor Capto AIEX Polishing Screening
PreDictor Capto CIEX Polishing Screening
PreDictor CIEX Screening
IEX selection kit
Capto Core 700
Capto Core 400
MabSelect™ PrismA
MabSelect SuRe
First choice for optimal produc-tivity, cleaning,
and sanitization in continuous and batch processes
For good performance and
assurance
Highselectivity
at broadpH/saltwindow
Capto™ L
Second choice
High-resolution polishingof mAbs
Highselectivity
at broadpH/saltwindow
For largemolecules/
viruses
For largemolecules/
viruses
Forsupercoiled
plasmid DNA†
Postprotein A
puri�cationof mAbs
High-resolutionpolishingof mAbs
For largemolecules/
viruses
Largemolecules
Largemolecules
mAbseparation
mAbseparation
Largemolecules
Highselectivity
at broadpH/saltwindow
Highselectivity
at broadpH/saltwindow
Optimal MM* resin for target protein is
known
Screen di�erent
MM resins
PreDictor Capto AIEX Polishing Screening
PreDictor Capto CIEX Polishing Screening
PreDictor Capto AIEX Polishing Screening
PreDictor Capto CIEX Polishing Screening
Screen di�erent
IEX resins
Cation exchanger
Forrecombinant
proteins
PreDictor Capto AIEX Polishing Screening
PreDictor Capto CIEX Polishing Screening
Largemolecules
For adeno- associated
viruses
For monoclonal antibodies
and Fc fusion proteins
For antibody fragments
Bind/elute mode
Flow-through mode
Screen di�erent
IEX resins
Screen di�erent
HIC resins
Anion exchanger
ACA�nity
chromatographyA�nity
chromatography
IEXIon exchange
chromatography
HICHydrophobic
interactionchromatography
MMMultimodal
chromatography
Save time with integrated design of experiments (DoE)
NOTE! Additional selection of resins are available for most applications.Size exclusion chromatography resins are not covered in this guide to modern resins. For availability please refer to gelifesciences.com/bioprocess
60
5040
30
20
10
pH
11.0
10.8
10.6
10.4
10.2
10.0
RSD = 14.5
20 30 40 50 60NaCl in wash (mM)
Optimize your methods efficiently using the DoE tool integrated into ÄKTA™ avant chromatography system. This feature allows you to plan and automatically run an experimental series that maximizes the amount of information obtained from a minimum number of experiments.
Capture: isolate, concentrate, and stabilize Intermediate: remove bulk impurities Polishing: achieve final high-level purity
* Available in formats from 80 µL to 5 L† Thiophilic aromatic adsorption