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Great new Krebs cycle (Citric Acid cycle) movie…. http:// www.youtube.com/watch?v =A1DjTM1qnPM. fig 16-13. Krebs cycle features and functions …. fig 16-13. O. CH 3 -C. O -. O. O. CH 3 -C. CH 3 -C. it’s all about acetate…. acetate. acetyl group. acetyl coenzyme A or acetyl-CoA. - PowerPoint PPT Presentation
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Lecture 7 Slides
Great new Krebs cycle (Citric Acid cycle) movie…
fig 16-13
http://www.youtube.com/watch?v=A1DjTM1qnPM
Krebs cyclefeatures andfunctions…
fig 16-13
CH3-CO
O-
CH3-CO
acetate
acetyl group
S-CoA
AcCoA
acetyl coenzyme Aor
acetyl-CoA
CH3-CO
it’s all about acetate…
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fig16-1
all roads lead to acetyl-CoA…
fig16-1
electrons from acetyl groups
fig16-1
energy from electrons
fig16-3
This is HS-CoA, or CoA-SH, CoA, or coenzyme A
fig16-3
This is HS-CoA, or CoA-SH, CoA, or coenzyme A
CoA-SH, or HS-CoA, or CoA
fig16-2
where the acetyl groups come from
pyruvate dehydrogenase: PDH
fig 14-13
Thiamine pyrophosphate (TPP): an activated carbon
fig 14-13
TPP as a carbanionnucleophile in pyruvate metabolism
fig16-4
The “business end” of PDH
Lipoic acid cofactor of PDH E2
fig16-5
The PDH complex approx. 4.5 x 106 MW
fig16-5
The PDH complex
fig16-6 (old)
The PDH catalyticcycle
oxidation of pyruvate
Several reactions, one basic location
fig16-6
Please read and LEARN
“The Name Game”
fig16-7
The:Krebs cyclecitric acid cycleTCA cycle
fig 16-8
Citrate synthase and its substrates…
pg 622
Getting fresh carbons into the act
why it’s called the citric acid cycle
pg 622
making citrate asymmetric
remember this for later…
fig16-10
an iron-sulfer cluster in aconitase
pg 624 (less fancy picture)
electrons!
NADH is the main carrier ofKrebs cycle-derived electrons
pg 625
more electrons!
note CoA-SH has re-entered the picture
pg 626
direct production of a high energy phosphate
but not ATP…instead it’s GTP
pg 626
direct production of a high energy phosphate
but not ATP…instead it’s GTP
pg 628
electrons to FAD instead of NAD+
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The business end of FAD or FMN
isoalloxazinering
pg 628
electrons to FAD instead of NAD+
pg 628
a sensible inhibitor of succinate dehydrogenase
INHIBITOR
old pg 612
Hydration of fumarate
pg 628
Hydration of fumarate
pg 628
high specificity exemplified by substrates and productsof fumarase
substrate
product
not asubstrate
pg 628
high specificity exemplified by substrates and productsof fumarase
not aproduct
substrate
product
pg 628
the final electron removal
Krebs cyclefeatures andfunctions…
fig 16-13
