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GRAVE’S DISEASE
By: Trevor Brighton
QUICK OVERVIEW
Grave’s disease is a thyroid gland disorder which
causes the accelerated production of the thyroid
hormones known as Thyroxine and Triiodothyronine.
This condition is called hyperthyroidism which can
and will affect the normal functions of the hormones.
It’s most common symptoms are, eye irritation and
swelling, dryness of skin, insomnia, goiters,
hyperactivity and over all abnormal mental behavior.
NORMAL THYROID ACTIVITY
The pituitary gland releases Thyroid
stimulating hormones(or TSH for short)
which go on to attach themselves to a
Thyroid cell receptor which signals the
cell to begin producing the 2 thyroid
borne hormones(Thyroxine and
Triiodothyronine). This production is
regulated and once the right amount
NORMAL THYROID ACTIVITY CONT’D.
of the hormones are made, some of it
goes back to the pituitary gland as a
negative feedback signal. Once that
happens the gland shuts off the Thyroid
stimulating hormones.
NORMAL THYROID ACTIVITY ANIMATION
GRAVE’S DISEASE AFFECTED THYROID ACTIVITY
Thyroid activity with Grave’s Disease doesn’t
even involve the pituitary gland, an auto-
antibody attaches itself to the receptor of the
thyroid cell and triggers the cell to begin
producing the hormones only now since there
is no system of negative feedback the
production is unregulated and thus leads to a
huge excess of the hormones which is again
known as hyperthyroidism.
GRAVE’S DISEASE AFFECTED THYROID ACTIVITY ANIMATION