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Graft Rejection 1990-2008
James Heaf
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Patient Survival
90-94 95-99 00-04 >2004
0,0 0,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0
Time
0,85
0,86
0,87
0,88
0,89
0,90
0,91
0,92
0,93
0,94
0,95
0,96
0,97
0,98
0,99
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Graft Survival
90-94 95-99 00-04 >2004
0 1 2 3 4 5 6 7 8
Time
0,50
0,55
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Combined Patient and Graft Survival
90-94 95-99 00-04 >2004
0,0 0,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0 4,5 5,0
Time (years)
0,50
0,55
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Combined Survival after One Year
90-94 95-99 00-04 >2004
1 2 3 4 5 6
Time
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Donor Type & Graft Loss
Prognosis
Donor Type & Death
Prognosis
Donor Height & Graft Survival
<170 170-180 >180
0 1 2 3 4 5 6 7 8
Time
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
cm
p<0.06
Censored for DeathNS
Donor Relation, Rejection & Graft Loss
Rejection Graft Loss
Donor AgeRejection Graft Loss
Donor Age & Rejection
Donor Age and Delayed Graft Function
<40 40-50 >50
0 5 10 15 20 25 30
Time (Days)
0,05
0,10
0,15
0,20
0,25
0,30
0,35
0,40
Pro
po
rtio
n w
itho
ut
Fu
nct
ion
Age(years)
Rejection Number and Banff Grade
Rejection & Cohort
90-94 95-99 00-04 >2004
0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00
Time
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Re
ject
ion
-fre
e S
urv
iva
l
Graft Survival after 1st Rejection & Cohort
90-94 95-99 00-04 >2004
0 1 2 3 4 5 6
Time
0,35
0,40
0,45
0,50
0,55
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Graft Survival after Rejection
4 3 2 1 0
0 1 2 3 4 5
Survival Time (Years)
0,4
0,5
0,6
0,7
0,8
0,9
1,0
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
RejectionNumber
Censored for Death
Rejection Frequency & Cohort
% 90-94 95-99 00-04 04-07
3 mth 28 26 23 14
1 yr 33 31 29 20
2 yr 35 33 31 22
Time to 1st Rejection & Graft Loss
<1 week 1-52 weeks >1 year
0 1 2 3 4 5 6
Time (years)
0,1
0,2
0,3
0,4
0,5
0,6
0,7
0,8
0,9
1,0
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Delayed Graft Function & Cohort
90-94 95-99 00-04 >2004
0 5 10 15 20 25 30
Time (Days)
0,05
0,10
0,15
0,20
0,25
0,30
0,35
0,40
0,45
0,50
Pro
po
rtio
n w
itho
ut
Fu
nct
ion
Delayed Graft Function & Donor Type
Delayed Graft FunctionRejection Graft Loss
Prognosis
Delayed Graft Function and Banff Grade
Delayed Graft Function andSurvival after First Rejection
no yes
0 2 4 6 8
Time (years)
0,40
0,45
0,50
0,55
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Gra
ft S
urv
iva
l
Censored for DeathP<0.001
AB Mismatch Number
DR Mismatch Number
Immunisation, Rejection & Graft Loss
Banff Grade & Rejection Number
Banff Grade & Graft SurvivalAll Rejections
Borderline 1 2 3
0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00
Time (years)
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Cu
mu
lativ
e P
rop
ort
ion
Su
rviv
ing
Chronic Rejection, Rejection Number & Graft Loss
Banff Grade & Cohort
Rejection and Transplant Center Transplants after 2000 Only
Rigshospital Herlev Odense Skejby
0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00
Time
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
1,05
Rej
ectio
n-fr
ee S
urvi
val
NotSignificant
Recipient Age & Rejection
<20 20-40 40-60 >60
0 1 2 3 4 5 6 7 8
Time (years)
0,60
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Re
ject
ion
-fre
e S
urv
iva
l
Pretransplant ESRD and Rejection
Preemptive <5 years >5 years
0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00
Time (years)
0,65
0,70
0,75
0,80
0,85
0,90
0,95
1,00
Re
ject
ion
-fre
e S
urv
iva
l
Risk Factors for Rejection
*
*
*
**
***
***
* p<0.05; **p<0.01; ***p<0.001
Risk Factors for Graft Loss
****
***
***
***
***
* p<0.05; **p<0.01; ***p<0.001
****
*
Risk Factors for Graft Loss + Death
****
***
*
***
*
* p<0.05; **p<0.01; ***p<0.001
*
***
Risk Factors for Death
***
***
* p<0.05; **p<0.01; ***p<0.001
***
