· GOPAVAK is a monovalent vaccine against salmonellosis of pigeons. It contains formalin inactivated cultures of immunogenic bacterial strain Salmonella typhimurium var. Copenhagen,

4VADEMECUM

VADEMECUMCONTENTS

BIOLOGICAL PREPARATIONS .............................................................................................................. BACTERIAL VACCINES Gopavak ............................................................................................................................................................................... Poliovin ................................................................................................................................................................................. Ery-lip ....................................................................................................................................................................................VIRUS VACCINES Lasovak ................................................................................................................................................................................ Broned-ol ............................................................................................................................................................................. Kilapin ................................................................................................................................................................................... Morbivak .............................................................................................................................................................................. Pest-ol ...................................................................................................................................................................................CHEMOPHARMACEUTICAL PREPARATIONS ....................................................................ANTIBIOTICS Gentamicin sol ................................................................................................................................................................. Hemutin 2% ....................................................................................................................................................................... Hemutin CTC ..................................................................................................................................................................... Hemutin – S ....................................................................................................................................................................... Neomicin 70 ...................................................................................................................................................................... Neomicin 245 ................................................................................................................................................................... Oksitetraciklin LA ........................................................................................................................................................... Streptomicin sulfat ........................................................................................................................................................ Tilozin 200 .......................................................................................................................................................................... SULPHONAMIDES Sulfamidin ........................................................................................................................................................................... Hemosul – P ...................................................................................................................................................................... Hemosul – S ......................................................................................................................................................................CHEMOTHERAPEUTICS Enrocin 10% ...................................................................................................................................................................... Enrocin - P .......................................................................................................................................................................... Enrocin – S 5% ................................................................................................................................................................. Enrocin – S 10% .............................................................................................................................................................. Flumekvin ............................................................................................................................................................................ANTIHELMINTHICS Helmizol – S ....................................................................................................................................................................... Ivermektin – P ................................................................................................................................................................... Ivermektin – S ................................................................................................................................................................... ECTO-ANTIPARASITICS Ektanon ................................................................................................................................................................................ ANALGOANTIPYRETICS Novpiron ...............................................................................................................................................................................ANALEPTICS Coffeinum cum natrii benzoate ...............................................................................................................................

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ANTIANEMICS Parafer ...........................................................................................................................................................................................VITAMINS Vitamin AD3E-S ........................................................................................................................................................................ Vitamin C .....................................................................................................................................................................................VITAMINS WITH MINERALS Promtselen ..................................................................................................................................................................................PREPARATIONS AGAINST KETOSIS Ketal ................................................................................................................................................................................................NUTRITIVES Glucosum ....................................................................................................................................................................................OTHER HEMOPHARMACEUTICALS Calcium borogluconicum ....................................................................................................................................................DIETARY SUPPLEMENTS ..................................................................................................................................... Subovitol AD3E ......................................................................................................................................................................... Neosaningest ............................................................................................................................................................................. Živimicin tov ............................................................................................................................................................................... Amivit ............................................................................................................................................................................................. Vitamin C ..................................................................................................................................................................................... Laksantiv ......................................................................................................................................................................................

DERMOCOSMETIC PRODUCTS ............................................................................................................... Flogo mast .................................................................................................................................................................................. Zinc- vitaminska mast ........................................................................................................................................................... Ihtiol- kamfor mast .................................................................................................................................................................. NOTES ...........................................................................................................................................................................................

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VADEMECUM

BIOLOGICAL PREPARATIONS

7VADEMECUM

ATCVet: QI01EB**

COMPOSITION: 1 ml of vaccine contains: Active ingredients: Formalin-inactivatedbacterial culture Salmonella typhimurium var. Copenhagen at least 40 a.u./ml of serum

TARGET SPECIES: Pigeons.

INDICATIONS: Active immunization of healthy pigeons against infection caused by Salmonella typhimurium var.Copenhagen.

DOSAGE: Vaccine is used in pigeons in a dose which is: For small and middle sized pigeons: 1 mlFor heavy breed pigeons: 1.5 mlVaccination is performed twice, at least 14 days apart.

ADMINISTRATION: Vaccine is subcutaneously administered in the neck area.

CONTRAINDICATIONS: Vaccine is contraindicated in very young pigeons (younger than 4 weeks), carriers, in sick,cachectic animals, and those invaded by parasites, as well as in animals during egg production cycle and layingeggs. Do not apply the vaccine directly before transport.

ADVERSE REACTIONS: Just sometimes it may cause short-time sadness and/or loss of appetite in the treatedanimals. Transient swelling, allergies, or anaphylactic reactions may occur at the vaccine injection point.

WITHDRAWAL PERIOD: Meat of the treated pigeons is not for human consumption 3 weeks upon vaccination.

STORAGE CONDITIONS: Keep away from children. Keep at temperatures from +2°C up to +8°C in originalpackaging. Do not freeze the vaccine.

EXPIRY DATE: 1 year.Expiry date after opening: Vaccine is to be administered shortly after openingDo not use the medicine after the date indicated on the packaging.

PACKAGING: 50 ml glass vial in a cardboard box.

GOPAVAK®Vaccine with inactivated bacterial culture Salmonella typhimurium var. CopenhagenSolution for injection. For animal use

BACTERIAL VACCINES

NOTE: Shake the vaccine vial each time before administration. Immunity in pigeons is formed after 14 days after vaccination, and after revaccination it can last up to one year. Vaccination of young pigeons can be performed only after they are fully feathered. After performed vaccination, pigeons should not be let out to fly for at least the following 60 days. Vaccination may be performed only in winter months, i.e in the period of reproductive cessation. Sick and infected pigeons are not to be vaccinated and such individual pigeons should be humanely destroyed, and the lofts and landing boards should be disinfected thereupon. Antimicrobial medicines are not to be used at least 5 days prior and 5 days after the vaccination of pigeons. If the use of antimicrobial medicines is necessary, revaccina-tion must be performed. In case of allergic reactions or anaphylactic reactions, adrenalin, and if necessary, antihista-mines and glucocorticoids, should be immediately applied.

EFFECTS: GOPAVAK is a monovalent vaccine against salmonellosis of pigeons. It contains formalin inactivated cultures of immunogenic bacterial strain Salmonellatyphimurium var. Copenhagen, which stimulates creation of specific antibodies againstthis pathogen. Immunity in pigeons is formed after 14 days, and after revaccination itcan last up to one year.

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8VADEMECUM

POLIOVIN®Vaccine containing inactivated bacteria Cl. perfringens type A, C i D, Cl. novyi tip B, Cl.septicum, F. necrophorum, Staph. aureus i A. pyogenesFor animal use

ATCVet: QI04AG**

COMPOSITION: 1 dose (2 ml) of vaccine contains Active ingredients:Inactivated bacterial cultures:Cl. perfringens tip A i alfa toksoid ≥ 2,5 i.j. alfa antitoksin*Cl. perfringens tip C i beta toksoid ≥ 10 i.j. beta antitoksin*Cl. perfringens tip D i epsilon toksoid ≥ 5 i.j. epsilon antitoksin*Cl. novyi tip B i toksoid ≥ 3,5 i.j. antitoksin*Cl. septicum i toksoid ≥ 2,5 i.j. antitoksin*Fusobacterium necrophorum ≥ 40 Ag.j.*Staphylococcus aureus ≥ 0,5 A.h.j*Arcanobacterium pyogenes ≥ 80 Ag.j.*Adjuvant: Aluminium-hydroxide 5,0 mg - 8,4 mgExcipients:Tiomersal (preservative) 0,1 mg - 0,2 mgFormaldehyde, residual (inactivator) maximum 3,2 mg*antibody titer in ml of rabbit serum

TARGET SPECIES: Sheep, lambs (over 3 months of age), goats, and kid goats (over 3 months of age).

DOSAGE: Vaccine dose is 2 ml, regardless of age, body mass, or breed..

WITHHOLDING PERIOD: No limitations. STORAGE CONDITIONS: Keep away from children. Keep the vaccine at temperatures from +2°C up to +8°C inoriginal packaging, to protect it from light. Do not freeze.EXPIRY DATE: 2 years. PACKAGING: 100 ml vial (50 doses).

BACTERIAL VACCINES

EFFECTS: POLIOVIN stimulates the formation of active immunity in sheep and goats against lamb dysentery (necrotic enterotoxaemia caused by Cl. perfringens type A), enterotoxaemia caused by Cl. perfringens types D and C, malignant edema (Cl. septicum), bradzota (necrotic hepatitis caused by Cl. novyi type B), and infectious lameness (Fusobacterium necrophorum and Corynebacterium pyogenes). Sheep and lambs also acquire resistance against clostridial metritis caused by Cl. septicum and gangrenous mastitis (Staphylococcus pyogenes).

INDICATIONS: Active immunization of sheep and goats against infections caused by Clostridium perfringens types A, C, and D, Clostridium septicum, Clostridium novyi type B, Fusobacterium nechrophorus, Staphylococcus aureus, and Arcanobacterium pyogenes. Antibody titer reaches the highest level at least 14 days after revaccination. Accord-ing to the field test data, immunity lasts at least for one year.

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, and animals infected/infested by parasites. Vaccine should not be administered before transport, decision to use this vaccine before or after adminis-tering other veterinary medicines must be made on a case by case basis.

ADVERSE REACTIONS: Common adverse effect is a small (<10 cm) swelling at the injection point, which will pass in several days after vaccination, with no adverse effects.

NOTE: In animals for slaughtering, apply the vaccine at some alternative point, thus possible swelling or change in tissue color would cause the least economic damage due to throwing away. Shake the vial containing the vaccine before use. Use dry and sterile needles and injectors. Do not use the needle used to administer the vaccine to an animal for taking the vaccine from the vial.

ADMINISTRATION: Vaccine is administered precisely subcutaneously into the knee wrinkles, neck area or at the chest behind the blades, respecting the principle of asepsis and antisepsis (injection should be applied at the point where the skin is dry and clean, to avoid possible infections).At the first vaccination, sheep should be vaccinated twice, with a 21-day interval. At revaccination, a year after the first vaccination, a one-time dose should be administered..

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9VADEMECUM

ERY-LIP®Vaccine containing inactivated bacteria Erysipelotrix rhusiopathiaeFor animal use

ATCVet: QI09AB03

EFFECTS: It stimulates the formation of active immunity against the pathogens oferysipelas in pigs.

TARGET SPECIES: Pigs.

INDICATIONS: Active immunization of pigs against erysipelas.

DOSAGE: Dose of the vaccine contains 2 ml.

WITHDRAWAL PERIOD: No limitations.

STORAGE CONDITIONS: In original packaging, at temperatures from +2 ºC to 8ºC, protected from light. Keep away from children.

EXPIRY DATE: 2 years.

PACKAGING: 100 ml vial in a cardboard box.

BACTERIAL VACCINES

COMPOSITION: 1 dose (2 ml) of the vaccine contains inactivated bacteria Erysipelotrixrhusiopathiae (strain VZS-L 624), minimum 10exp8 CFU

ADMINISTRATION: Vaccine is to be administered subcutaneously (behind the ear), one time only. All healthy animals older than 3 months of age are to be vaccinated. Depending on the epizootiological situation, vaccination may be administered on animals younger than 3 months of age, i.e. at the earliest to piglets of 3 weeks of age. Revaccina-tion is obligatory in 6 to 8 weeks after the first vaccination for animals vaccinated when younger than 3 months of age. Pregnant sows are to be vaccinated in the first third of the gestation period, and revaccinated 5 to 6 weeks after parturition.

NOTE: Before application it is necessary to implement aseptic and antiseptic measures and disinfect the skin at the injection point. Immediately before and during vaccination, vial with vaccine should be occasionally well shaken. Use only sterile equipment for vaccination. Immunity of the treated animals is formed 14 days after vaccination, it is fully developed after the 21st day, and lasts for 7 to 8 months. In case of accidental self-injection of the vaccine, immedi-ately seek medical help and show the packaging or the instructions for use to the doctor. The doctor must immediately perform incision and rinse the injection point, especially if a finger, pads of the fingers, or tendons are affected.

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, animals infected by parasites, and heavily pregnant sows. Also, the vaccine should not be applied 4 weeks before and after applying glucocorticoids or hyperimmune serum.

ADVERSE REACTIONS: Just sometimes, at the injection point in vaccinated animals, swelling may occur (which spontaneously resolves), along with (or without) slight body temperature increase and short term inappetence.

For this method of vaccine administration, first remove the cap and pipette from the plastic vial containing the solvent, and then open the vaccine glass vial, with 25 or 50 doses. Then put the opening of the glass vial to the opening of the plastic one, gently shake until the vaccine is dissolved. Then separate the vials, so that the dissolved vaccine remains in the plastic vial, on which the pipette is mounted. Vaccines with 1000 and 2000 doses are dissolved using a needle and a syringe.Such dissolved vaccine is administered oculonasally to chickens in a dose, i.e. quantity of 0.1 ml, i.e. 2 drops. After closing the beak and one nostril with the finger, one drop should be put in the second nostril, and the other drop in the eye.

NOTE: Dissolved vaccine should be used as soon as possible (within no more than 3 hours) and protect from direct sun exposure. During oculonasal vaccination, take care not to touch the chicken eye and nostrils with the dropper. When applying aerosol vaccination of broiler chickens, always consult the specialist service.Inadequate vaccine application, above all through dispersion, may cause the increased percentage of adverse effects in treated animals.

ADVERSE REACTIONS: Just sometimes when applying the vaccine through dispersion (using an aerosol appara-tus), mild and transient breathing disorder may occur, especially in young chickens. If you notice a serious or any other adverse effect not mentioned in these instructions, please immediately notify the authorized veterinarian.

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, and animals infected by parasites. Do not administer the vaccine directly before transport.

For this method of vaccine administration, first remove the cap and pipette from the plastic vial containing the solvent, and then open the vaccine glass vial, with 25 or 50 doses. Then put the opening of the glass vial to the opening of the plastic one, gently shake until the vaccine is dissolved. Then separate the vials, so that the dissolved vaccine remains in the plastic vial, on which the pipette is mounted. Vaccines with 1000 and 2000 doses are dissolved using a needle and a syringe.Such dissolved vaccine is administered oculonasally to chickens in a dose, i.e. quantity of 0.1 ml, i.e. 2 drops. After closing the beak and one nostril with the finger, one drop should be put in the second nostril, and the other drop in the eye.

NOTE: Dissolved vaccine should be used as soon as possible (within no more than 3 hours) and protect from direct sun exposure. During oculonasal vaccination, take care not to touch the chicken eye and nostrils with the dropper. When applying aerosol vaccination of broiler chickens, always consult the specialist service.Inadequate vaccine application, above all through dispersion, may cause the increased percentage of adverse effects in treated animals.

ADVERSE REACTIONS: Just sometimes when applying the vaccine through dispersion (using an aerosol appara-tus), mild and transient breathing disorder may occur, especially in young chickens. If you notice a serious or any other adverse effect not mentioned in these instructions, please immediately notify the authorized veterinarian.

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, and animals infected by parasites. Do not administer the vaccine directly before transport.

10VADEMECUM

BACTERIAL VACCINESLASOVAK®Vaccine containing live virus of the Newcastle disease, La Sota strain and suspension solvent for injection for animal use

ATCVet: QI01AD06

COMPOSITION: 1 dose of vaccine contains:Active substance: Live attenuated virus of the Newcastle disease, La Sota 106- 107 EID50

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TARGET SPECIES: Chickens and turkey poults.

INDICATIONS: Active chickens and turkey poults immunization against the Newcastle disease.

DOSAGE: Oculonasal application: 0.1 ml, i.e. two dropsApplication using the dispersion method: Dissolve 1000 doses of the vaccine in 250 ml of distilled water.

ADMINISTRATION:Oculonasal use:

Dispersion method (aerosol):

EFFECTS: LASOVAK stimulates the development of active immune response of poultry to the Newcastle disease virus. Active component in the vaccine composition is the Newcastle disease virus, La Sota strain, which stimulates creation of specific antibodies in vaccinated animals.

This method of vaccine administration is mostly used in older chickens (second and third vaccination), due to weaker adverse effects in these animals. However, due to the advantage of quick immunity formation and saving time, very young chickens can be vaccinated in this way, in cases when the infection already broke out on the farm, or if there is a threat of the immediate danger of bringing in the virus.For this kind of vaccination, dissolve 1000 doses of the vaccine in 250 ml of distilled water. The size of particles for aerosol-ization should be 100 – 120 microns. The dissolved vaccine (using an aerosol apparatus) is dispersed at the height of 50 cm to 1 m above the ground, in a completely enclosed hen house. After performed dispersion (i.e. vaccination), animals should not be disturbed in an enclosed hen house for half an hour.Time of vaccination depends on epizootiological situation and origin of the chickens, i.e. the immune state in chickens and turkey poults. In chickens and turkey poults from immune mothers, the first vaccination is performed at the age of 8 to 12 days, and the other at the age of 2.5 to 3 months, due to the presence of maternal antibodies in their blood, which may suppress immunity development. If it is required by the epizootiological situation, vaccination may be performed in the first days of life, but then the revaccination is to be performed at the end of the third and at the beginning of the fourth week. At the age of 3 months, chickens for breeding are to be vaccinated for the third time. Vaccine may also be used for active immunization of adult poultry, but the vaccination must be repeated every 3 months due to shorter immune intervals. Time of vaccination and revaccination in large agglomerations should be determined based on the flock’s immunity status. During vaccination and until immunity has fully developed, certain measures should be taken to prevent infection from being introduced into the breeding stock.

Air temperature from 20°C to 22°C, as well as relative humidity in the facility from 60 to 70%, make optimal conditions for performing aerosol vaccination. Equipment and water used for vaccine dissolution and preparation, when applied through dispersion, must be clean, with no detergents, disinfectants, chlorine, and metal salts.

Air temperature from 20°C to 22°C, as well as relative humidity in the facility from 60 to 70%, make optimal conditions for performing aerosol vaccination. Equipment and water used for vaccine dissolution and preparation, when applied through dispersion, must be clean, with no detergents, disinfectants, chlorine, and metal salts.

11VADEMECUM

WITHHOLDING PERIOD: Zero (0) days.STORAGE CONDITIONS: Keep away from children.Lyophilisate: Keep at temperatures up to 2 °C in original packaging, protected from light.Do not freeze.Solvent (if kept separated from lyophilisate): Keep at temperatures up to +25°C in original packaging. Do not freeze.LYOPHILISATE EXPIRY DATE: 1 year. SOLVENT EXPIRY DATE: 36 months. Expiry date after reconstitution: 3 hours at the temperature up to 25°C, protected from light.

PACKAGING:Box with 1 vial of lyophilisate (25 doses) and 1 vial of solvent (2.5 ml).Box with 1 vial of lyophilisate (50 doses) and 1 vial of solvent (5 ml).Box with 5 vials of lyophilisate (5x1000 doses) + box with 5 vials of solvent (5x100 ml) Box with 5 vials of lyophilisate (5x2000 doses) + box with 10 vials of solvent (10x100 ml)

VIRUS VACCINESLASOVAK®Vaccine containing live virus of the Newcastle disease, La Sota strain Lyophilisate for suspensionFor animal use

ADMINISTRATION: Preparation is administered subcutaneously (s.c.) in the neck or intramuscularly (i.m.) in the chest musculature. Poultry is vaccinated at the age of 16 – 18 weeks, i.e. prior to laying. Before applying BroNED-ol vaccine, chicken must be vaccinated with live vaccines of infectious bronchitis and Newcastle disease. The period between application of the live vaccine and booster vaccination with BroNED-ol vaccine must not be shorter than 2 weeks. The best booster effect is achieved 6 weeks after application of the live vaccine.

ADMINISTRATION: Preparation is administered subcutaneously (s.c.) in the neck or intramuscularly (i.m.) in the chest musculature. Poultry is vaccinated at the age of 16 – 18 weeks, i.e. prior to laying. Before applying BroNED-ol vaccine, chicken must be vaccinated with live vaccines of infectious bronchitis and Newcastle disease. The period between application of the live vaccine and booster vaccination with BroNED-ol vaccine must not be shorter than 2 weeks. The best booster effect is achieved 6 weeks after application of the live vaccine.

12VADEMECUM

VIRUS VACCINESBRONED-OL®Vaccine containing inactivated virus of the Newcastle disease (La Sota strain) Virus of infectious bronchitis (H52 strain), inactivated virus of the egg drop syndrome (BC14 strain)

ATCVet: QI01AA13

COMPOSITION: 1 dose (1 ml) of vaccine containsActive substance:Inactivated virus of the Newcastle disease (La Sota strain), minimum 6x102 HU/doseVirus of infectious bronchitis (H52 strain), minimum 5x102 HU/doseInactivated virus of the egg drop syndrome (BC14 strain), minimum 6x102 HU/dose

TARGET SPECIES: Poultry.

INDICATIONS: Active immunization of future consumable and parent flocks of egg laying hens against the eggdrop syndrome, infectious bronchitis, and Newcastle disease.

DOSAGE: Preparation is administered in a dose of 1 ml.

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CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic poultry, and poultry infected by parasites.Do not administer the vaccine directly before transport.

ADVERSE REACTIONS: In rare cases, at the injection point in vaccinated poultry, a few weeks after administeringthe injection, a tissue reaction may occur (swelling and redness), which spontaneously resolves.


STORAGE CONDITIONS: Keep at temperatures from +2°C to +8°C, protected from light.Keep away from children.

EXPIRY DATE: 1 year.Expiry date after reconstitution: 24 hours.Do not use the medicine after the date indicated on the packaging.


Vaccine containing the inactivated virus of the Newcastle disease (La Sota strain), virus of infectious bronchitis (H52 strain), and virus of the egg drop syndrome (BC14 strain)

EFFECTS: It stimulates the formation of active immunity in poultry against virus of the egg drop syndrome (EDS, 76), infectious bronchitis, and Newcastle disease. The vaccine stimulates the organism in the vaccinated poultry to create specific antibodies against the effects of the pathogen virus, while oil adjuvant in the vaccine composition increases the effects of antibodies and provides a long-term immunity.

NOTE: Before use, the vaccine should be heated to the room temperature, i.e. it should be kept at room temperature for 24 hours. Immediately before and during vaccination, vial with vaccine should be occasionally well shaken. After opening a vial, vaccine should be administered within the following 24 hours. Use only sterile equipment for vaccina-tion.

EFFECTS: In pigs, KILAPIN stimulates the formation of active immunity against classical swine fever caused by the RNA virus from the Pestivirus strain of the Flaviviridae family. In healthy pigs, immunity is developed not later than 14 days after injecting KILAPIN vaccine. In animals vaccinated when they were over 3 months old, the immunity lasts for at least 6 months after vaccination. Piglets vaccinated when they were 40 to 50 days old must be revaccinated when they are three months old, that is 4 weeks after the first vaccine application.

EFFECTS: In pigs, KILAPIN stimulates the formation of active immunity against classical swine fever caused by the RNA virus from the Pestivirus strain of the Flaviviridae family. In healthy pigs, immunity is developed not later than 14 days after injecting KILAPIN vaccine. In animals vaccinated when they were over 3 months old, the immunity lasts for at least 6 months after vaccination. Piglets vaccinated when they were 40 to 50 days old must be revaccinated when they are three months old, that is 4 weeks after the first vaccine application.

13VADEMECUM

VIRUS VACCINESKILAPIN®

ATCVet: QI09AD04

Live attenuated lapinized classical swine fever virus (China strain) minimum 100 PD50

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INDICATIONS: Active immunization against classical swine fever.Vaccination is performed in accordance with the prescribed Animal Health Protection Measures Program.

DOSAGE: The vaccine is administered intramuscularly in a 1 ml dose, regardless of the age of the pig.


EXPIRY DATE: 1 year Expiry date after reconstitution: use immediately. Do not use after the date indicated on the packaging.

PACKAGING:Lyophilisate: Glass vial with 10 doses of the vaccine and glass vial with 20 dosesSecondary packaging: Cardboard box with 5x10 doses of the vaccine and cardboard box with 5x20 doses of thevaccine.Solvent: Polypropylene vial with 10 ml of solvent and polypropylene vial with 20 ml of solvent.Secondary packaging: Cardboard box with 5x10 ml of solvent and cardboard box with 5x20 ml of solvent.

Vaccine containing live virus of classicalswine fever (China strain) Lyophilisate and suspension solvent for injection. For animal use

COMPOSITION: One dose (1 ml) of the vaccine containsactive ingredients:

ADMINISTRATION: After reconstitution in an appropriate amount of the enclosed solvent (1 dose is reconstituted in 1 ml of solvent), the vaccine is only administered intramuscularly, namely in the inside of the thigh for younger animals, and in the neck musculature for adult animals

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, and animals infected by parasites. Also, the vaccine should not be applied 4 weeks before and after applying glucocorticoids. If the piglets come from immunized sows, they should not be vaccinated before they are 6 to 8 weeks old due to possible interference with maternal antibodies.

NOTE: Only healthy animals are to be vaccinated. After vaccinating, keep the pigs in isolation for at least 14 days to prevent possible contact with animals infected with the classical swine fever virus.The vaccine application (injection) point must not be disinfected with alcohol or any other disinfectant.

STORAGE CONDITIONS: Lyophilisate: Keep at temperatures from +2°C to +8°C, protected from light. Do not freeze. Solvent: Packaged separately from the vaccine, the solvent can be stored at temperatures up to 25°C in original packaging.

ADVERSE REACTIONS: A slight swelling (<1 cm) and redness may sometimes occur at the injection point, which will pass spontaneously and without treatment within several days. Short-term hyperthermia may sometimes occur in vaccinated animals within a week after vaccinating. The vaccine contains heterologous proteins of rabbits and horses. Allergic reaction is possible after reapplying the vaccine.If you notice a serious or any other adverse effect not mentioned in these instructions, immediately notify the authorized veterinarian or veterinary institution thereof.

14VADEMECUM

VIRUS VACCINESMORBIVAK®

ATCVet: QI09AD01

COMPOSITION: Vaccine contains attenuated virus strainof Aujeszky’s disease (Bartha strain) minimum1x10exp3TCID /dose.50

EFFECTS: Causing active immune response in healthypigs and piglets against Aujeszky’s disease.


INDICATIONS: Active immunization of healthy pigs and piglets againstAujeszky’s disease.

DOSAGE:

ADMINISTRATION: Vaccine is administered subcutaneously (s.c.) in the inside of the thigh area.

NOTE: Dissolve the vaccine before use, shake gently, and apply using only a sterile syringe and needle.


STORAGE CONDITIONS: In original packaging, at temperatures from +2°C to +8°C, protected from light.Keep away from children.

EXPIRY DATE: 1 year.

PACKAGING: Cardboard box (5 vials x 20 doses of the vaccine) and a cardboard box (5 vials x 20 ml of solvent).

Vaccine containing live attenuated virus of Aujeszky’s disease (Bartha strain)For animal use

After dissolution, the quantity of the vaccine to be applied is 1 ml.Piglets originating from immunized mothers shall be vaccinated seven days before weaning, and piglets originating from non-immunized mothers shall be vaccinated when they are at least 14 days old. All piglets shall be revaccinated when they are three to four weeks old. The immunity is developed within 14 days and after revaccination, animal protection lasts one year.

CONTRAINDICATIONS: The vaccine must not be used in sick, cachectic, reconvalescent animals, nor to animals infected by parasites. Also, the vaccine is not to be used in animals exposed to stress (labeling and transport). The vaccine shall not be used for the immunization of other animal species against Aujeszky's disease.

ADVERSE REACTIONS: Transient local hyperthermia and swelling may sometimes occur at the injection point in vaccinated animals. In case of severe allergic reactions after the vaccination, animals are to be treated with adrena-line and antihistamines (intramuscularly).

NOTE: Before use, the vaccine should be heated to the room temperature, i.e. it should be kept at room temperature for 24 hours. Immediately before and during vaccination, vial with vaccine should be occasionally well shaken. After opening a vial, the vaccine should be administered within the following 24 hours.Use only sterile equipment for vaccination. Three months before administering PEST-ol , hens should be vaccinated with attenuated vaccine against atypical fever.

NOTE: Before use, the vaccine should be heated to the room temperature, i.e. it should be kept at room temperature for 24 hours. Immediately before and during vaccination, vial with vaccine should be occasionally well shaken. After opening a vial, the vaccine should be administered within the following 24 hours.Use only sterile equipment for vaccination. Three months before administering PEST-ol , hens should be vaccinated with attenuated vaccine against atypical fever.

15VADEMECUM

VIRUS VACCINESPEST-OL®

ATCVet: QI01AA02

COMPOSITION: In 0.5 ml, vaccine contains: Active substance:Inactivated virus of the Newcastle disease, La Sota strain: HI titer ≥4 log 2

TARGET SPECIES: Egg laying hens immediately prior to laying.

INDICATIONS: Active immunization against the Newcastle disease (atypical avian influenza).Immunity occurrence period is 2 to 3 weeks. Immunity lasts until the end of the production cycle.

DOSAGE: Vaccine should be administrated in a dose of 0.5 ml.

ADMINISTRATION: The vaccine is administered intramuscularly (i.m.) in the chest musculature.

CONTRAINDICATIONS: The vaccine is not to be used in sick, cachectic animals, nor in animals infectedby parasites. Do not apply the vaccine directly before transport.

ADVERSE REACTIONS: Swelling may sometimes occur at the injection point in vaccinated animals,which spontaneously resolves by itself.

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STORAGE CONDITIONS: In original packaging, at temperatures from +2ºC to +8°C, protected from light.Keep away from children.

EXPIRY DATE: 1 year. The vaccine is to be administered shortly after the first opening.

PACKAGING: 50 ml vial.

Inactivated oil vaccine against atypical avian influenza. Emulsion for injection.For animal use.

EFFECTS: Vaccine is used for active immunization of egg laying hens immediately prior to laying, to prevent occurrence of atypical avian influenza caused by pathogenic Newcastle virus. Vaccine contains Newcastle disease virus multiplied on chicken embryos, inactivated with formaldehyde and suspended in oil adjuvant.

CHEMOPHARMACEUTICAL

PREPARATIONS

17VADEMECUM

ANTIBIOTICSGENTAMICIN SOL.Solution for injection for animal use Antibiotic

ATCVet: QJ01GB03

COMPOSITION: 1 ml of solution for injection contains: Active substance:Gentamicin (in the form of gentamicin-sulfate) 80 mg

TARGET SPECIES: Cattle, pigs, and dogs.

DOSAGE: To be used intramuscularly

EFFECTS: Gentamicin is from a group of aminoglycoside antibiotics, so it has an especially efficient effect on microorganisms which multiply rapidly. It is obtained from Micromonospora purpurea and other similar microorganisms. It consist of three similar compounds with antibacterial features, called gentamicin C1, gentamicin C2, and gentamicin C3.Gentamicin is a bactericidal antibiotic, and each of its abovementioned parts has almost identical level of antibacterial effect. Since gentamicin does not have effect only on gram-negative, but also on gram-positive bacteria, it is considered that gentamicin belongs to wide-spectrum antibiotics.Gentamicin binds to the 30 S subunit of the bacterial cell ribosome and thereby inhibits protein synthesis. In that, it affects large number of codes than other aminoglycoside antibiotics.It is effective against Pseudomonas aeruginosa, Proteus spp., Escherichia coli, Klebsiella spp., Aerobacter spp., Staphylococcus spp. , Streptococcus spp., etc.

INDICATIONS: Treatment of bacterial infections caused by microorganisms susceptible to gentamicin, after perform-ing an antibiogram: infection of gastrointestinal, respiratory, and urinary tract, infection of the skin and soft tissues.

– For large animals (cattle and pigs) 2.5 ml/100 kg of body mass, i.e. 1 ml per 40 kg of body mass, every 12 hours.– For dogs, the first day of treatment 0.5 ml/10 kg of body mass twice daily, and for the other treatment days 0.25 ml per 10 kg of body mass once daily.Do not administer more than 20 ml of the medicine in case of large animals and 10 ml in case of small animals at the same injection point. Treatment lasts for 3 – 5 days.

CONTRAINDICATIONS: The medicine is not to be used in animals hypersensitive to gentamicin. Further on, gentamicin is not to be used in animals with ear diseases, liver and kidney diseases, during the gestation period, and newborn animals. The medicine is not to be used in animals receiving other ototoxic medicines.The medicine is not to be used in rabbits. Do not use in lactating animals.

ADVERSE REACTIONS: In case of subcutaneous (s.c.) medicine application, a pain may occur, while in case of other ways of administration there are no local reactions. Long-term application, as well as larger doses of gentamicin may cause damages of kidneys, hearing, or balance.Allergic reaction to gentamicin and other aminoglycoside antibiotics might occur, as well as damage of the inner ear. Gentamicin may cause neuromuscular weakness, nausea, and increase in transaminase and alkaline phosphatase. Gentamicin has a depressive effect on the heart rate.If you notice serious, or any adverse effect not mentioned herein, please notify the authorized veterinarian thereof.

NOTE: In animals with decreased renal function due to illness or old age, frequency of dosage, and not the dose quantity, i.e. medicine quantity, should be reduced, which depends on the level of the damage of organ functions. Gentamicin is excreted by simple glomerular filtration, so the frequency of dosage must be determined based on the estimate of creatinine clearance rate or urea in the blood, and based on that, the frequency of medicine administra-tion should be decreased. Proper determination of hearing, vestibular, and kidney function is particularly needed in animals with additional risk factors: reduced liver function, reduced hearing function, bacteremia, and fever may cause the risk of the occurrence of ototoxicity.

ADMINISTRATION: Medicine is administrated intramuscularly twice a day, 12 hours apart (mornings – evenings) in a dose of 2 mg of gentamicin per 1 kg of body mass in case of all animals (i.e. 4 mg of gentamicin per kg of body mass per day).

Packaging: Inner packaging: a dark glass vial (type II), with 100 ml of solution for injection, sealed with a rubber stopper, and an aluminum cap. Outer packaging: cardboard folding box with 1 vial of 100 ml of solution for injection and Instruction for the medicine..

Packaging: Inner packaging: a dark glass vial (type II), with 100 ml of solution for injection, sealed with a rubber stopper, and an aluminum cap. Outer packaging: cardboard folding box with 1 vial of 100 ml of solution for injection and Instruction for the medicine..

18VADEMECUM

ANTIBIOTICSGENTAMICIN SOL.Solution for injection for animal useAntibiotic

STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.

EXPIRY DATE: 3 years Expiry date after opening: 28 days at the temperature of 25°C.

Precautions are recommended in cases of significant animal obesity. Special attention should be paid in cases of illnesses with muscle weakness. With possible allergic reactions, treatment should be terminated, and animals should be given the adrenaline, and antihistamines and glucocorticoids later.

WITHDRAWAL PERIOD: The meat of treated animals is not for human consumption during treatment, as well as 72 days upon the last medicine administration. The milk of treated animals is not used for human consumption.

Pigs: For treating enzootic bronchopneumonia and dysentery, tiamulin is used in a treatment dose of 5 - 10 mg/kg of body mass, during 7 to 10 days. In cases of severe manifestations of illness, preparation HEMUTIN 2% premix is applied in the quantity of 1 kg per 100 kg of feed, or 10 kg per 1 t of feed, during 7 to 10 successive days. In cases of mild manifestations of illness, preparation is used in half of the dose, i.e. quantity, that is 0.5 kg of HEMUTIN 2% should be applied per 100 kg of feed, or 5 kg per 1 ton of feed, during 7 to 10 successive days. In case of recidive of illness, tiamulin should be applied parenterally.Poultry: For treatment of mycoplasmal and bacterial respiratory infections, tiamulin is used in a treatment dose of 25 mg/kg of body mass. Preparation HEMUTIN 2% is used in the quantity of 25 kg per 1 ton of feed, during 5 successive days.

CONTRAINDICATIONS: The medicine is not to be used in conjunction with monensin, narasin, and salinomycin, neither 7 days before nor after treating animals with listed medicines. Not to be used in pregnant sows (during the early gestation period - the first four weeks after mating), lactating sows, breeding boars, nor egg laying hens.

ADVERSE REACTIONS: Allergic reactions may occur, manifested by acute skin inflammation, i.e. skin redness, swelling, and intensive itching may occur, as well as edema and rectal mucous membrane redness in pigs. Possible inappetence in pigs and poultry.

NOTE: Tiamulin must not be mixed with feed with iodophorm kokcidiostatics, such are: monensin, narasin, maduramy-cin, lasalocid, etc. Even after 2 days after the consumption of this feed, the symptoms of poisoning occur in pigs: anorexia, sleepiness, paraplegia, and coma, and in poultry: inappetence, body mass loss, and myocardial damage. Mortality usually occurs after 5 to 10 days from the occurrence of symptoms of poisoning.

Pigs: For treating enzootic bronchopneumonia and dysentery, tiamulin is used in a treatment dose of 5 - 10 mg/kg of body mass, during 7 to 10 days. In cases of severe manifestations of illness, preparation HEMUTIN 2% premix is applied in the quantity of 1 kg per 100 kg of feed, or 10 kg per 1 t of feed, during 7 to 10 successive days. In cases of mild manifestations of illness, preparation is used in half of the dose, i.e. quantity, that is 0.5 kg of HEMUTIN 2% should be applied per 100 kg of feed, or 5 kg per 1 ton of feed, during 7 to 10 successive days. In case of recidive of illness, tiamulin should be applied parenterally.Poultry: For treatment of mycoplasmal and bacterial respiratory infections, tiamulin is used in a treatment dose of 25 mg/kg of body mass. Preparation HEMUTIN 2% is used in the quantity of 25 kg per 1 ton of feed, during 5 successive days.

CONTRAINDICATIONS: The medicine is not to be used in conjunction with monensin, narasin, and salinomycin, neither 7 days before nor after treating animals with listed medicines. Not to be used in pregnant sows (during the early gestation period - the first four weeks after mating), lactating sows, breeding boars, nor egg laying hens.

ADVERSE REACTIONS: Allergic reactions may occur, manifested by acute skin inflammation, i.e. skin redness, swelling, and intensive itching may occur, as well as edema and rectal mucous membrane redness in pigs. Possible inappetence in pigs and poultry.

NOTE: Tiamulin must not be mixed with feed with iodophorm kokcidiostatics, such are: monensin, narasin, maduramy-cin, lasalocid, etc. Even after 2 days after the consumption of this feed, the symptoms of poisoning occur in pigs: anorexia, sleepiness, paraplegia, and coma, and in poultry: inappetence, body mass loss, and myocardial damage. Mortality usually occurs after 5 to 10 days from the occurrence of symptoms of poisoning.

19VADEMECUM

ANTIBIOTICIHEMUTIN® 2%Premiks za mediciniranu hranuza primenu na životinjamaAntibiotik

ATCVet: QJ01XQ01

COMPOSITION: 1 g of premix for medicated feed contains:Tiamulin hydrogen fumarate 20 mg

TARGET SPECIES: Pigs and poultry.INDICATIONS:

DOSAGE:

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ADMINISTRATION: The medicine is used mixed with feed.When mixing the medicine into feed, take care the medicine is evenly mixed.

WITHDRAWAL PERIOD: Not to be administered to egg laying hens.Pigs: Meat, intestines and other edible tissues: 5 daysPoultry: Meat, intestines and other edible tissues: 3 days

STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging.Keep away from children.

EXPIRY DATE: 2 years.Expiry date after first opening: 3 months, at temperatures up to +25°C.Expiry date after mixing with feed: 3 months, at temperatures of up to +25°C.Do not use the medicine after the date indicated on the packaging.

PACKAGING: 25 kg three-layer paper bag.

EFFECTS: Tiamulin is half-synthetic bacteriostatic antibiotic, with a powerful antibacterial effect on Brachyspira (Serpulina) hyodysenteriae, Mycoplasma, Leptospira, numerous gram-positive and some gram-negative bacteria.

Pigs: Bloody diarrhea treatment (Brachyspira (Serpulina) hyodysenteriae) and other intestine infections caused by microorganisms susceptible to tiamulin, including: Intestinal spirochetosis (Brachyspira (Serpulina) pilosicoli), and ileitis (Lawsonia intracellularis). Respiratory diseases treatment: Enzootic pneumonia (Mycoplasma hyopneumoniae) and other infections in pigs caused by microorganisms susceptible to tiamulin. Poultry: Respiratory diseases treatment in poultry caused by mycoplasma (CRD) and secondary infections caused by microorganisms susceptible to tiamulin.

20VADEMECUM

ANTIBIOTICSHEMUTIN® CTC

ATCVet: QJ01RA90

COMPOSITION: 1g of premix contains: Tiamulin hydrogen fumarate 33.3 mgChlortetracycline (in the form of hydrochloride) 100 mg


DOSAGE: Piglets up to 8 weeks of age: 2 kg of premix per 1 ton of feed, that is 200 g of premix per 100 kg of feed.Piglets older than 8 weeks of age: 3 kg of premix per 1 ton of feed, that is 300 g of premix per 100 kg of feed.In severe infections that last longer:Piglets up to 8 weeks of age: 3 kg of premix per 1 ton of feed, that is 300 g of premix per 100 kg of feed.Piglets older than 8 weeks of age: 4.5 kg of premix per 1 ton of feed, that is 450 g of premix per 100 kg of feed.

ADMINISTRATION: HEMUTIN CTC is used mixed with feed, for 7 to 10 days. When mixing the medicine into feed,take care the medicine is evenly mixed.

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WITHDRAWAL PERIOD: For the pig meat, 10 days after the last use of the medicine.

STORAGE CONDITIONS: Keep at temperatures up to 25°C in original packaging. Keep away from children.

EXPIRY DATE: 2 years.Expiry date after opening: use immediately. Expiry date after mixing with feed: use immediately. Do not use the medicine after the date indicated on the packaging.

PACKAGING: 1 kg bag (in a cardboard box) and a 25 kg bag.

Premix for medicated feed for animal use Antibiotic

EFFECTS: Tiamulin is a half-synthetic antibiotic, with a positive effect on Brachyspira (Serpulina) hyodysenteriae, Mycoplasma spp., Leptospira spp., numerous gram-positive and some gram-nega-tive bacteria.Chlortetracycline is a large spectrum antibiotic, with bacteriostatic effects, but in larger concentra-tions, and it has bactericidal effects in case of sensitive microorganisms. It is active against gram-positive and gram-negative bacteria (E. coli, Bacillus spp., Brucella spp., Clostridium spp., Corynebacterium spp., Haemophilus sp., Klebsiella sp., Pasteurella spp., Salmonella spp., Shigella spp., Staphylococcus spp. , Streptococcus spp., Vibrio spp., Leptospira spp.), coccidia, mycoplas-mas, moraxella, and rickettsia.

INDICATIONS: Treatment of infections in pigs caused by microorganisms susceptible to tiamulin and chlortetracycline, such as: Respiratory tract infections: enzootic pneumonia (Mycoplasma pneumoniae) and other diseases caused by mycoplasma, pleuropneumonia (Actinobacillus pleuropneumoniae), atrophic rhinitis (Bordetella bronchiseptica, Pasteurella multocida), and secondary bacterial pneumonia. Gastrointestinal tract infections: dysentery (Brachyspira (Serpulina) hyodysenteriae with Campylobacter (Vibrio) coli, Fusobacterium necrophorum, Bacteroides spp., Clostridium perfringens), colibacillosis, necrotic enteritis (Clostridium perfringens of type C) coupled with Salmonella cholerae suis, secondary bacterial infection after transmissible gastroenteritis (TGE). Genitourinary system infections: cystitis, nephritis, metritis, MMA syndrome in sows.

CONTRAINDICATIONS: Not to be used in animals hypersensitive to tetracyclines. Not to be used in animals with liver diseases and kidney failure.The medicine is not to be used in conjunction with monensin, narasin, and salinomycin, neither 7 days before nor after treating animals with listed medicines.Not to be used in pigs during early gestation – the first 4 weeks after mating, nor in breeding boars.

ADVERSE REACTIONS: In rare cases, erythema, pruritus, and other signs of hypersensitivity, as well as diarrhea and vomiting may occur. In such cases, the treatment should be discontinued. In young animals, chlortetracycline may cause discolouration of teeth.

NOTE: Tiamulin is incompatible with monensin, narasin, and salinomycin, therefore it is not to be used at the same time, neither 7 days before nor after the use of these medicines.

NOTE: Tiamulin is incompatible with monensin, narasin, maduramycin, and salinomycin, therefore it is not to be used at the same time, neither 7 days before nor after the use of these medicines. HEMUTIN -S is compatible with lasalocid and semduramicin.

NOTE: Tiamulin is incompatible with monensin, narasin, maduramycin, and salinomycin, therefore it is not to be used at the same time, neither 7 days before nor after the use of these medicines. HEMUTIN -S is compatible with lasalocid and semduramicin.

21VADEMECUM

ANTIBIOTICSHEMUTIN®-SSolution for injectionfor animal useAntibiotic

ATCVet: QJ01XQ01

COMPOSITION: 1 ml of solution for injection contains:Tiamulin 200 mg


DOSAGE: Treatment of bloody diarrhea: 0.5 ml/10 kg of body mass, one time only.Treatment of mycoplasmal pneumonia: 0.50 – 0.75 ml/10 kg of body mass/day, for 3 to 5 days. Treatment of mycoplasmal polyserositis, and polyarthritis: 0.75 ml/10 kg of body mass/day, for 3 days.

CONTRAINDICATIONS: Not to be used in sows in the last month of gestation. Not to be used in breeding boars.

ADVERSE REACTIONS: After administration of the preparation, erythema or mild swelling may sometimes occur at the injection point.

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WITHDRAWAL PERIOD: The meat of treated pigs is not for human consumption during the treatment, aswell as 28 days after the last medicine application.


EXPIRY DATE: 2 years. Expiry date after opening: 28 days.Do not use the medicine after the date indicated on the packaging.

PACKAGING: 50 ml or 100 ml glass vial in a cardboard box.

EFFECTS: Tiamulin is a semisynthetic, macrolide antibiotic which acts against gram-positive and some gram-negative microorganisms, particularly against Brachyspira hyodysenteri-ae and Mycoplasma spp.

INDICATIONS: The treatment of bloody diarrhea, mycoplas-mal pneumonia, mycoplasmal polyserositis and polyarthritis.

ADMINISTRATION: The medicine is to be administered by deep intramuscular injection (i.m.).The maximum volume of the preparation applied at one point is 5 ml. If the required volume of the medicineexceeds 5 ml, it should be divided in half and applied at different injection points. When applying the medicine,use dry sterile needle and syringe

22VADEMECUM

ANTIBIOTICSNEOMICIN 70Premix for medicated feed for animal use Antibiotic

ATCVet: QA07AA01

COMPOSITION: 1 g of premix contains:Neomycin (in the form of neomycin sulfate) 70 mg

TARGET SPECIES: Pigs, foals, calves, lambs, kid goats, and poultry.

DOSAGE: Neomycin sulfate dose is:for calves, foals, lambs, and kid goats 10 – 20 mg/kg of body massfor pigs 10 – 15 mg/kg of body massfor poultry 10 – 30 mg/kg of body massTo be used in all animals in the amount of: 3 – 3.5 kg/t of feed or 3 – 3.5 g/kg of feed.

WITHDRAWAL PERIOD: For meat and edible tissues of pigs, calves, lambs, foals, kid goats: 10 days.For broiler chickens meat: 5 days. Not to be used in egg laying hens.


EXPIRY DATE: 3 years.Expiry date after opening: 3 months, at temperatures up to +25°CExpiry date after mixing with feed: 3 months, at temperatures up to +25°CDo not use the medicine after the date indicated on the package.

PACKAGING: 1 kg bag in carton box.

EFFECTS: Neomycin is an aminoglycoside antibiotic with a spectrum of activity which primarily includes gram-negative aerobic microorganisms, including enterobacteria - E.Coli, Salmonella spp., Shigella spp., Enterobacter aerogenes, as well as numerous strains of Pseudomonas aeruginosa.

INDICATIONS: Treatment of acute and subacute, primary and secondary infections of the gastrointestinal tract in the target species caused by susceptible microorgan-isms (mainly by gram-negative aerobic microorganisms: E. coli, Salmonella spp, Shigella spp, Enterobacter aerogenes, Pseudomonas aeruginosa).

ADMINISTRATION: The preparation is to be used mixed with feed. It is to be used daily for 5 to 7 days.If after 2 – 3 days of treatment the condition does not improve, the therapy must be changed. Due to the possibledevelopment of resistance, the medicine should not be given in doses smaller than recommended, nor the duration of therapy should be shortened.CONTRAINDICATIONS: Not to be used in dehydrated animals, animals with constipation and impaired renal function.Not to be used in animals with known hypersensitivity to aminoglycoside antibiotics.

ADVERSE REACTIONS: Very rarely, after administering higher doses than recommended, or when applying for a prolonged period of time, neomycin may cause nephrotoxicity, diarrhea accompanied by malabsorption, as well as fungal superinfection. In sensitive animals, allergic reactions are possible.

NOTE: Simultaneous administration of neomycin with penicillin V leads to malabsorption of penicillin.Also, in the presence of neomycin, the resorption of digitalis preparations (digoxin in particular) and vitamin K from the digestive tract decreases. The simultaneous use with Henle's loop diuretics (furosemide, ethacrynic acid) or osmotic diuretics (mannitol, urea) may lead to potentiation of ototoxic effect of neomycin and other aminoglyco-sides.Simultaneous administration of neomycin with other nephrotoxic medicines may lead to an increase of nephrotoxic effect of neomycin. Resorption of methotrexate can be reduced by peroral administration of neomycin. In case of allergic reactions, antihistamines and, if necessary, glucocorticoids should be immediately applied.

23VADEMECUM

ANTIBIOTICSNEOMICIN 245Oral powderfor animal use Antibiotic

ATCVet: QA07AA01

COMPOSITION: 1g of powder contains:Neomycin (in the form of neomycin sulfate) 245 mg

TARGET SPECIES: Pigs, calves, foals, lambs, kid goats, and poultry.

WITHDRAWAL PERIOD: Meat, intestines, and other edible tissues: pigs, calves, lambs, foals, and kid goats: 10 days broiler chickens: 5 daysNot to be used in egg laying hens.

STORAGE CONDITIONS: Keep at temperatures up to +25°C, in original packaging. Keep away from children.

EXPIRY DATE: 3 years.Expiry date after first opening: 3 months, at temperatures up to +25°C.Expiry date after diluting in drinking water: 24 hours, at temperatures up to +25°C. Do not use the medicine after the date indicated on the packaging.

PACKAGING: 100 g bag.

EFFECTS: Neomycin is an aminoglycoside antibiotic with a spectrum of activity which primarily includes gram-negative aerobic microorganisms, including enterobacteria – E.Coli, Salmonella spp., Shigella spp., Enterobacter aerogenes, as well as numerous strains of Pseudomonas aeruginosa.

INDICATIONS: Treatment of acute and subacute, primary and secondary infections of the gastrointestinal tract in the target species caused by susceptible microorgan-isms (mainly by gram-negative aerobic microorganisms: E. coli, Salmonella spp, Shigella spp, Enterobacter aerogenes, Pseudomonas aeruginosa).

DOSAGE: Neomycin sulfate dose is:For calves, foals, lambs, and kid goats 10 – 20 mg/kg of body massFor pigs 10 – 15 mg/kg of body massFor poultry 10 – 30 mg/kg of body massTo be used in all animals in the amount of 5 g per 10 liters of water, or 0.5 g per 1 liter of water.

ADMINISTRATION: The preparation is used mixed with drinking water. It is to be used daily for 5 to 7 days. It is necessary to prepare fresh solution every day.If after 2 – 3 days of treatment the condition does not improve, the therapy must be changed.Due to the possible development of resistance, the medicine should not be given in doses smaller than recommended, nor should the duration of therapy be shortened.

CONTRAINDICATIONS: Not to be used in dehydrated animals, animals with constipation and impaired renal function.Not to be used in animals with known hypersensitivity to aminoglycoside antibiotics.

ADVERSE REACTIONS: Very rarely, after administering higher doses than recommended, or when applying for a prolonged period of time, neomycin may cause nephrotoxicity, diarrhea accompanied by malabsorption, as well as fungal superinfection. In sensitive animals, allergic reactions are possible.

NOTE: Simultaneous administration of neomycin with penicillin V leads to malabsorption of penicillin. Also, in the presence of neomycin the resorption of digitalis preparations (digoxin in particular) and vitamin K from the digestive tract decreases. The simultaneous use with Henle's loop diuretics (furosemide, ethacrynic acid) or osmotic diuretics (mannitol, urea) may lead to potentiation of ototoxic effect of neomycin and other aminoglycosides.

24VADEMECUM

ANTIBIOTICSOKSITETRACIKLIN LASolution for injectionfor animal useAntibiotic

ATCVet: QJ01AA06

COMPOSITION: 1 ml of solution for injection contains: Oxytetracycline (in the form of dihydrate) 200 mg

TARGET SPECIES: Cattle, pigs, and sheep.

ADMINISTRATION: The medicine is to be administered by deep intramuscular injection (i.m.).


EXPIRY DATE: 4 years. Expiry date after opening: 28 days.Opening date should be marked on the label of the vial.Do not use the medicine after the date indicated on the packaging.


EFFECTS: Oxytetracycline is a tetracycline antibiotic of a large spectrum of application, isolated from a culture of Streptomyces rimosus. It has bacteriostatic effect, and at higher doses, bactericidal effect. The oxytetracycline mechanism of action is based on binding to the 30s ribosomal subunit and interfering with bacterial RNA, i.e. on the inhibition of bacterial protein synthesis. By blocking the binding of aminoacyl-tRNA to ribosomes, it hinders the incorporation of amino acids into polypeptide chains, that is the bacterial proteins synthesis. Only a small part of oxytetracycline binds irreversibly, therefore it is considered to be reversibly bound to oxytetracycline responsible for the antibacterial effect. Oxytetracycline is effective against numerous gram-positive and gram-negative bacteria(Escherichia coli, Streptococcus spp., Staphylococcus spp., Salmonella spp., Leptospira spp., Shigella spp., Brucella spp., Pasteurella spp., Clostridium spp., Erysipelothrix spp, Listeria spp., Moraxella bovis, Fusobacterium necrophorum, Actinobacillus spp., etc.), mycoplasma, chlamydia, rickettsia, and some protozoa. Oxytetracycline is not active against Proteus spp, Pseudomonas spp., Serratia spp., M. hyopneumoniae, and M. bovis.

INDICATIONS: The treatment of cattle, pigs, and sheep diseases, caused by microorganisms susceptible to oxytetracy-cline: bronchopneumonia, gastroenteritis, septicemia, metritis, mastitis (general therapy), puerperal infections, securing surgical procedures.

DOSAGE: The medicine dose for all animals is 1 ml/10 kg of body mass, one time only, and in severe cases the dose may be repeated after 3 to 4 days.

CONTRAINDICATIONS: Not to be used in animals hypersensitive to oxytetracycline and other tetracyclines. Not to be used in early gestation, in the last trimester of gestation, as well as very young animals not older than three weeks. Not to be used in animals with impaired liver function and kidney failure.

NOTE: Not to be administered intravenously!At one injection point, it should not be applied more than: 20 ml to cattle, 10 ml pigs, and 5 ml to sheep. If the dose is to be repeated, it should be administered at another injection point.

WITHDRAWAL PERIOD: The meat of the treated animals is not for human consumption during the treatment and 21 days after the last medicine application. The medicine is not to be used in animals whose milk is used for human consumption.

ADVERSE REACTIONS: Vomiting and transient diarrhea.At the injection point a slight swelling may appear, which spontaneously resolves without intervention within several days. Tetracyclines administered in a higher dose than a therapeutic dose may have a nephrotoxic effect. This effect was also observed in long-acting tetracyclines.Tetracyclines have antianabolic effect and may cause azotemia which may deteriorate by additional application of glucocorticoids. This medicine may also cause metabolic acidosis and electrolyte imbalance. Prolonged application of tetracycline causes liver damage. In young animals, deposits in bones and discolouration of teeth may occur.

25VADEMECUM

ANTIBIOTICSSTREPTOMICIN SULFATOral powderfor animal use Antibiotic

ATCVet: QA07AA04COMPOSITION: 1 g of oral powder contains:Streptomicin sulfate 1 g

TARGET SPECIES: Foals, calves, pigs, piglets, poultry.

EFFECTS: Streptomycin is an aminoglycoside antibiotic that is effective against most gram-negative and some gram-positive microorganisms.Streptomycin sulfate binds to the 30 S subunit of the bacterial cell ribosome and thereby inhibits protein synthesis and interferes with proper transcription of the genetic code. The wrong amino acid is built into the protein molecule and the emerging protein becomesdysfunctional. In addition, streptomycin prevents the incorporation of amino acids into the cytoplasmic membrane which in this manner loses the selective barrier properties.Particularly susceptible to streptomycin are: Pasteurella spp., Brucella spp., Haemophilus spp., Salmonella spp., Shigella spp., Klebsiella spp., and Mycobacterium tuberculosis, and is also effective against Corynebacterium spp., E. coli, Staphylococcus spp., Vibrio spp., and some Mycoplasma. Applied perorally, streptomycin passes unchanged through acidic environment of the stomach and effects the pathogenic intestinal flora.

ADMINISTRATION: The medicine is to be administered perorally in drinking water, milk, or milk substitute. Calves are treated orally only in the period until the establishment of rumen function. If necessary (severe infections), antibacterial medicines can be administerd to animals parenterally, as well. In case of allergic reactions, adrenalin, and if necessary, antihistamines, and glucocorticoids should be immediately applied.Not to be used in egg laying hens. When applying the medicine in poultry, dissolve the recommended amount of medicine in a small amount of a drinking water first and then in the remaining intended amount. This procedure should be repeated every time before application.

INDICATIONS: The medicine is intended for treatment of numerous gastrointestinal tract infections (colibacillosis, pasteurellosis, salmonellosis, vibrionic dysentery, different types of enteritis) and other infections caused by microorgan-isms susceptible to streptomycin in foals, calves, pigs, piglets, and poultry.

WITHDRAWAL PERIOD: The meat and edible organs of treated animals is not for human consumption during treatment, as well as 10 days upon the last medicine administration. The medicine is not to be used in egg laying hens.

ADVERSE REACTIONS: Only in some cases, primarily after the application over a longer period of time and in higher doses, after peroral application, Streptomycin may have harmful effect to the eighth cranial nerve and cause hearing impairment and balance disorder, as well as possible kidney damage and hypersensitivity reactions. The occurrence of diarrhea is possible, which resolves spontaneously.

CONTRAINDICATIONS: The application of preparation is contraindicated in animals that simultaneously receive other potentially ototoxic agents, general anesthetics, muscle relaxants, diuretics, then in case of myasthenia gravis, an extreme kidney damage, as well as in hypersensitive animals. The medicine is not to be administered simultaneously with tetracyclines, sulfonamides, macrolide antibiotics, and lincosamides.

NOTE: If the improvement of the health status of infected animals is not visible after 2 to 3 days from the start of the medicine administration, it is to be replaced by more efficient antibacterial medicine, according to a previously proven causal agent susceptibility. Reduced medicine efficacy is usually due to the presence of resistant strains of pathogenic microorganisms. This preparation may cause sensibility of the skin and mucous membranes, therefore usual precautions and protective measures must be taken during application. Fresh solution should be made daily, and the remaining amount of dissolved medicine should be disposed of safely.

DOSAGE: The medicine is applicable in the following doses:Calves and foals: 5 g of the medicine (1 scoop)/ 100 kg of body mass, 2x daily (every 12 hours),Pigs and piglets: 1 g of the medicine per 50 kg of body mass, 2x daily (every 12 hours),Poultry: 1 g of the medicine per 3 l of water or 5 g (1 scoop) per 15 l of water.The treatment is conducted during 3 to 5 successive days.

26VADEMECUM

ANTIBIOTICSSTREPTOMICIN SULFATOral powderfor animal use Antibiotic


EXPIRY DATE: 2 years. Expiry date 1 year after opening. Expiry date after reconstitution in drinking water 24h at thetemperature up to +25°C.

PACKAGING: 5 g Al bag and 1 kg PVC bag in a cardboard box.

EFFECTS: Tylosin has effect on some gram-positive bacteria, mycoplasma, as well as on some gram-negative bacteria. It is effective against Brucella sp., Diplococcus sp., Naisseria sp., Staphylococcus sp., Leptospira sp., Streptococcus sp., Shigella spp, and Vibrio spp. It also has effect on Haemophilus gallinarum, Haemophilus pertussis, erysipelotrix in turkey, spirochetes, Moraxella bovis, Pasteurella multocida, Fusobacterium necrophorum, Bracyspira hyodisenterae, Bacillus spp, Corynebacterium spp., Clostridium spp., as well as on Chlamydia species. However, in cattle, standard doses do not reach the concentration of tylosin that is effective against pasteurella. Tylosin suspectible are Borrelia anserina, mycoplasma species, rickettsias and some coccidia species.

EFFECTS: Tylosin has effect on some gram-positive bacteria, mycoplasma, as well as on some gram-negative bacteria. It is effective against Brucella sp., Diplococcus sp., Naisseria sp., Staphylococcus sp., Leptospira sp., Streptococcus sp., Shigella spp, and Vibrio spp. It also has effect on Haemophilus gallinarum, Haemophilus pertussis, erysipelotrix in turkey, spirochetes, Moraxella bovis, Pasteurella multocida, Fusobacterium necrophorum, Bracyspira hyodisenterae, Bacillus spp, Corynebacterium spp., Clostridium spp., as well as on Chlamydia species. However, in cattle, standard doses do not reach the concentration of tylosin that is effective against pasteurella. Tylosin suspectible are Borrelia anserina, mycoplasma species, rickettsias and some coccidia species.

27VADEMECUM

ATCVet: QJ01FA90

TARGET SPECIES: Cattle, pigs, sheep, dogs

ADMINISTRATION: The medicine is administered intramuscularly (i.m.). The medicine is to be applied once a day,and the therapy lasts 3 to 5 days.

STORAGE CONDITIONS: Keep at temperatures up to +25°C, in original packaging. Keep away from children. EXPIRY DATE: 2 years. Expiry date 28 days after opening. Do not use the medicine after the date indicated on thepackage.PACKAGING: 100 ml glass vial in a cardboard box.

ANTIBIOTICSTILOZIN 200Solution for injectionfor animal use Antibiotic

COMPOSITION: 1 ml of solution for injection contains:Active substance Tylosin 200 mg(in the form of a tylosin tartrate) 220 mg

Antimicrobial effects of tylosin is based on the inhibition of protein synthesis in bacterial cells. The medicine binds to the 50 S ribosomal subunit, which prevents binding of aminoacyl-tRNA and peptidyl-tRNA to ribosomes. Tylosin has a similar spectrum of activity as erythromycin, and in the case of Staphylococcus aureus, a cross-resistance occurs as well. When it comes to Brachyspira hyodysenteriae and Mycoplasma, Tylosin shows significantly stronger effect on these microorgan-isms than erythromycin.

INDICATIONS: The treatment of respiratory, gastrointestinal, and other infections caused by organisms susceptible to tylosin (enzootic bronchopneumonia, atrophic rhinitis, tonsillitis, tracheobronchitis, swine dysentery, nonspecific enteritis, mastitis) in cattle, sheep, pigs, and dogs.

CONTRAINDICATIONS: The medicine is not to be used in animals hypersensitive to tylosin. Not to be used in horses and small herbivores (rabbit, guinea pig, hamster, gerbil) in which it can cause fatal diarrhea. Diarrhea in horses, and sometimes death of adult horses, can be caused by intensive reproduction of anaerobe Cl. difficile in the intestine.

WITHDRAWAL PERIOD: Meat and intestines of treated cattle, sheep, and pigs are not for human consumption during the treatment and 28 days after the last medicine application.The milk of treated cows is not for human consumption during the treatment and 7 days after the last medicine application. The medicine is not to be used in sheep whose milk is used for human consumption.

ADVERSE REACTIONS: Pain, local reaction, or transient swelling may appear at the injection point, which spontaneouslyresolve within several days. In pigs, a rectal mucous membrane edema with slight protrusion may occur. Erythema and pruritus are rare. These occurrences are transient as well. In treated dogs and cats, anorexia, vomiting and diarrhea may occur. In horses, any method of tylosin administration (oral or intramuscular) may lead to severe, and even life-threatening diarrhea. In cattle, oral method of medicine administration can lead to severe diarrhea.NOTE: In cases of allergic reaction, treatment should be terminated immediately, and animals should be given the adrenaline, and later, if necessary, antihistamines and glucocorticoids. Do not administer more than 10 ml of medicine to cattle, i.e. not more than 5 ml to sheep and pigs, at the same injection point.

DOSAGE: The medicine is to be administered intramuscularly in the daily dose, or in the following medicine quantity, as specified for:cattle: 5 – 10 mg/kg of body mass or 2.5 – 5 ml of injection solution/100kg of body mass calves: 5 – 10 mg/kg of body mass or 1.25 – 2.5 ml of injection solution/50 kg of body mass pigs: 5 – 10 mg/kg of body mass or 1.25 – 2.5 ml of injection solution/50 kg of body mass piglets: 5 – 10 mg/kg of body mass or 0.25 – 0.5 ml of injection solution/10 kg of body masssheep: 10 mg/kg of body mass or 1 ml of injection solution/20 kg of body massdogs: 10 mg/kg of body mass or 0.5 ml of injection solution/10 kg of body mass

For treatment of pigeons, it is used in doses of 12.5 ml of SULFAMIDIN per 1 liter of drinking water. It is recommended to double the concentration of the medicine on the first day of treatment. Therapy is conducted during 3 to 5 successive days.The dose of the medicine should be adjusted to the current water consumption so that each bird receives the recommended dose. Treatment of coccidiosis should be conducted according to the 3-2-3 pattern, which means 3 days of therapy, 2 days without therapy, and the therapy is then repeated for another 3 days.

ADVERSE REACTIONS: Sulfonamides and thus sulfadimidine applied in therapeutic doses and the prescribed time period (up to 7 days) do not cause adverse effects. Hypersensitivity reactions may occur, but very rarely.In poultry, especially in young poultry, when sulfadimidine is introduced into the therapy through drinking water, reduced consumption of food or water can occur, with a consequential reduction in growth.Use of sulfadimidine in poultry during the first weeks of life can cause reduction of T3 levels in plasma and increase of LH level, which results in increase of testicles and faster puberty in male chickens.Nephrotoxic effect occurs when large doses are used over a longer period of time.The hemorrhagic syndrome is a manifestation of toxicity of sulfonamides and occurs when higher doses are used (but can also occur with therapeutic doses). Apart from blood dyscrasia, bone marrow depression and thrombocytopenia, sulfonamides can also have a depressing influence on the lymphatic system and immune function in birds.

CONTRAINDICATIONS: Allergies to sulfonamides, kidney and liver damage, anemia. The preparation is not to be adminis-tered to egg laying hens.

NOTE: Fresh solution of the medicine should be made daily. During treatment, prevent animals from drinking unmedicated water. In case of an infection, it is necessary to treat the entire breeding stock in which the infection occurred since it is impossible to determine which animals are incubated.

EFFECTS: SULFAMIDIN is an antimicrobial medicine from the group of sulfonamides. It has an effect on a number of gram-positive and gram-negative bacteria and certain protozoa, such as coccidia (especially second-generation schizonts). Sulfonamides have a mainly bacteriostatic effect and impede the process of biosynthesis of folic acid in the bacterial cell as competitive antagonists to para-aminobenzoic acid (PABA). By replacing PABA molecules and preventing synthesis of folic acid which is necessary for DNA synthesis, sulfonamides prevent the multiplication of the bacterial cell.

INDICATIONS: Treatment of infections caused by organisms susceptible to sulfadimidine (chicken coccidiosis, infectious coryza in poultry, chicken white diarrhoea and fowl typhoid, contagious enteritis in pigeons (paratyphoid)).DOSAGE: The medicine is administered orally, by adding it into drinking water.Sulfamidin is used in doses of 50 to 200 mg/kg of body mass. The medicine is administered in doses of 6.25 to 12.5 ml per 1 liter of drinking water.For treatment of pigeons, it is used in doses of 12.5 ml of SULFAMIDIN per 1 liter of drinking water. It is recommended to double the concentration of the medicine on the first day of treatment. Therapy is conducted during 3 to 5 successive days.The dose of the medicine should be adjusted to the current water consumption so that each bird receives the recommended dose. Treatment of coccidiosis should be conducted according to the 3-2-3 pattern, which means 3 days of therapy, 2 days without therapy, and the therapy is then repeated for another 3 days.

ADVERSE REACTIONS: Sulfonamides and thus sulfadimidine applied in therapeutic doses and the prescribed time period (up to 7 days) do not cause adverse effects. Hypersensitivity reactions may occur, but very rarely.In poultry, especially in young poultry, when sulfadimidine is introduced into the therapy through drinking water, reduced consumption of food or water can occur, with a consequential reduction in growth.Use of sulfadimidine in poultry during the first weeks of life can cause reduction of T3 levels in plasma and increase of LH level, which results in increase of testicles and faster puberty in male chickens.Nephrotoxic effect occurs when large doses are used over a longer period of time.The hemorrhagic syndrome is a manifestation of toxicity of sulfonamides and occurs when higher doses are used (but can also occur with therapeutic doses). Apart from blood dyscrasia, bone marrow depression and thrombocytopenia, sulfonamides can also have a depressing influence on the lymphatic system and immune function in birds.

CONTRAINDICATIONS: Allergies to sulfonamides, kidney and liver damage, anemia. The preparation is not to be adminis-tered to egg laying hens.

NOTE: Fresh solution of the medicine should be made daily. During treatment, prevent animals from drinking unmedicated water. In case of an infection, it is necessary to treat the entire breeding stock in which the infection occurred since it is impossible to determine which animals are incubated.

EFFECTS: SULFAMIDIN is an antimicrobial medicine from the group of sulfonamides. It has an effect on a number of gram-positive and gram-negative bacteria and certain protozoa, such as coccidia (especially second-generation schizonts). Sulfonamides have a mainly bacteriostatic effect and impede the process of biosynthesis of folic acid in the bacterial cell as competitive antagonists to para-aminobenzoic acid (PABA). By replacing PABA molecules and preventing synthesis of folic acid which is necessary for DNA synthesis, sulfonamides prevent the multiplication of the bacterial cell.

INDICATIONS: Treatment of infections caused by organisms susceptible to sulfadimidine (chicken coccidiosis, infectious coryza in poultry, chicken white diarrhoea and fowl typhoid, contagious enteritis in pigeons (paratyphoid)).DOSAGE: The medicine is administered orally, by adding it into drinking water.Sulfamidin is used in doses of 50 to 200 mg/kg of body mass. The medicine is administered in doses of 6.25 to 12.5 ml per 1 liter of drinking water.

28VADEMECUM

SULPHONAMIDESSULFAMIDIN®

Oral solutionfor animal use Sulfonamide

ATCVET: QJ01EQ03COMPOSITION: 1 ml of solution contains:Sulfadimidine sodium 160 mg

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ADMINISTRATION: In drinking water. Fresh solution of the medicine should be made daily.

WITHDRAWAL PERIOD: Meat, intestines and other edible tissues of broilers 14 days.The medicine is not to be used in egg laying hens.


EXPIRY DATE: 3 years. Expiry date after first opening 28 days, at temperatures up to +25°C. Expiry date afterdiluting in drinking water is 24 hours, at temperatures up to +25°C.Do not use the medicine after the date indicated on the packaging.

PACKAGING: Cardboard box containing a 100 ml white vial and a 1000 ml white bottle.

TARGET SPECIES: Broilers, breeders, parent flocks, pigeons.

EFFECTS: HEMOSUL P is a combination of bacteriostatic antiinfective medicine sulfamethoxazole (sulfonamide chemotherapeutic agent) and trimethoprim (diaminopyrimidine derivative). Each component alone acts bacteriostatically, while together they act synergistically, i.e. bactericidally, and often against microorganisms resistant to one or each of the components separately. Synergistic antibacterial effects of HEMOSUL P components are achieved by blocking two different stages in the biosynthesis of tetrahydrofolic acid in microorganisms. HEMOSUL P has a wide spectrum of activity on a

EFFECTS: HEMOSUL P is a combination of bacteriostatic antiinfective medicine sulfamethoxazole (sulfonamide chemotherapeutic agent) and trimethoprim (diaminopyrimidine derivative). Each component alone acts bacteriostatically, while together they act synergistically, i.e. bactericidally, and often against microorganisms resistant to one or each of the components separately. Synergistic antibacterial effects of HEMOSUL P components are achieved by blocking two different stages in the biosynthesis of tetrahydrofolic acid in microorganisms. HEMOSUL P has a wide spectrum of activity on a

29VADEMECUM

SULFONAMIDESHEMOSUL®-POral powderfor animal use Sulfonamide

ATCVet: QJ01EW11

COMPOSITION: 1 g of oral powder contains:Sulfamethoxazole 100 mgTrimethoprim 20 mg

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TARGET SPECIES: Calves and pigs.

INDICATIONS: HEMOSUL P is indicated in cases of infections caused by microorganisms susceptible to acombination of sulfamethoxazole and trimethoprim.

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ADMINISTRATION: The medicine is to be administered perorally, mixed with feed.

WITHDRAWAL PERIOD: Pigs, meat, and intestines: 10 daysCalves, meat, and intestines: 14 days


EXPIRY DATE: 3 years. Expiry date after opening and mixing with water/feed: 3 months. Do not use the medicine after the date indicated on the packaging.

PACKAGING: 100 g bag, 1 kg bag (in a cardboard box).

number of gram-positive and gram-negative bacteria, chlamydia, and protozoa. Particularly susceptible are gram-positive aerobic bacteria (Staphylococcus aureus, Streptococcus sp., Actinomyces sp., Corynebacterium sp., E.rhusopatthie, L. monocytogenes), gram-negative aerobic bacteria (Actinobacillus sp., Bordetella sp., Brucella sp., Enterobacteriaceae, as well as E. coli, Klebsiella sp., Proteus sp., Haemophilus sp., Pasteurella sp.), anaerobes (Actinomyces sp., Bacteroides sp., Fusobacterium sp.), Chlamydia sp., and protozoa (Toxoplasma).

DOSAGE: The total daily dose (quantity) of a medicine for all animal species amounts to 10 g of powder per 40 kg of body mass. The daily dose should be divided and given half a dose in the morning and half in the evening (every 12 hours). The treatment lasts 4 to 5 days, and maximum 7 days.

CONTRAINDICATIONS: Contraindicated is the use of this product in animals with impaired liver, kidney, and hematopoietic organs function, as well as in animals hypersensitive to sulfonamides and/or trimethoprim.

ADVERSE REACTIONS: Continuous administration of the preparation can cause kidney damage, liver necrosis, hepatitis, vomiting, diarrhea, emaciation, anorexia, photosensitization, pruritus, hemolytic anemia, thrombocytopenia, and allergic reactions.

NOTE: During the treatment, the animals should be provided with a sufficient amount of drinking water. Medicated feed should be prepared in a quantity which the animal can eat in one meal. The medicine should be administered based on the antibiogram results. In order to properly dose the medicine, the animal body mass should be determined as accurately as possible.

EFFECTS: HEMOSUL S is a combination of bacteriostatic antiinfective medicine sulfamethoxazole (sulfonamide chemotherapeutic agent) and trimethoprim (diaminopy-rimidine derivative). Each component alone acts bacteriostatically, while together they act synergistically, i.e. bactericidally, and often against microorganisms resistant to one or each of the components separately. Synergistic antibacterial effects of HEMOSUL S components are achieved by blocking two different stages in the biosynthesis of tetrahydrofolic acid in microorganisms. HEMOSUL S has a wide spectrum of activity on a number of gram-positive and gram-negative bacteria, chlamydia, and protozoa. Particularly susceptible are gram-positive aerobic bacteria (Staphylococcus aureus, Streptococcus sp., Actinomyces sp., Corynebacterium sp., E.rhusopatthie, L. monocyto-genes), gramnegative aerobic bacteria (Actinobacillus sp., Bordetella sp., Brucella sp.,

EFFECTS: HEMOSUL S is a combination of bacteriostatic antiinfective medicine sulfamethoxazole (sulfonamide chemotherapeutic agent) and trimethoprim (diaminopy-rimidine derivative). Each component alone acts bacteriostatically, while together they act synergistically, i.e. bactericidally, and often against microorganisms resistant to one or each of the components separately. Synergistic antibacterial effects of HEMOSUL Scomponents are achieved by blocking two different stages in the biosynthesis of tetrahydrofolic acid in microorganisms. HEMOSUL S has a wide spectrum of activity on a number of gram-positive and gram-negative bacteria, chlamydia, and protozoa. Particularly susceptible are gram-positive aerobic bacteria (Staphylococcus aureus, Streptococcus sp., Actinomyces sp., Corynebacterium sp., E.rhusopatthie, L. monocyto-genes), gramnegative aerobic bacteria (Actinobacillus sp., Bordetella sp., Brucella sp.,

30VADEMECUM

SULFONAMIDESHEMOSUL®-SSolution for injectionfor animal use Sulfonamide

ATCVet: QJ01EW11

COMPOSITION: 1 ml of solution for injection contains:Trimethoprim 40 mgSulfamethoxazole 200 mg

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TARGET SPECIES: Pigs

WITHDRAWAL PERIOD: Meat and pigs intestines: 28 days.

STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging, protected from light.Keep away from children.

EXPIRY DATE: 3 years. Expiry date after opening: 28 days. Do not use the medicine after the date indicated on the packaging.

PACKAGING: 100 ml vial in a cardboard box.

Enterobacteriaceae, as well as E. coli, Klebsiella sp., Proteus sp., Haemophilus sp., Pasteurella sp.) anaerobes (Actinomy-ces sp., Bacteroides sp., Fusobacterium sp.), Chlamydia sp., and protozoa (Toxoplasma).

INDICATIONS: Treatment of infections caused by microorganisms susceptible to the combination of trimethoprim and sulfamethoxazoleDOSAGE: The medicine is to be administered in a dose of 1 ml/10 – 15 kg of body mass, one time only.One-time application may be sufficient in uncomplicated conditions, but in more severe conditions it is necessary to apply the medicine once a day for several days, until two days after the withdrawal of symptoms, up to 5 days.

CONTRAINDICATIONS: Contraindicated is the use of this product in animals with impaired liver or kidney function, in oliguria and anuria, as well as in animals with impaired function of hematopoietic organs.Not to be used in animals with known hypersensitivity to sulfonamides and/or trimethoprim.

ADMINISTRATION: To be used intramuscularly (i.m)Not more than 10 ml of medicine should be applied at one point. The volume larger than anticipated should be divided and applied at multiple injection points.

NOTE: The medicine is not to be used in conjunction with para-aminobenzoic acid (PABA) and its derivatives (procaine, and other local anesthetics), as well as with B-complex vitamins (nicotinamide, folic acid, and choline) as they have an antagonistic effect on sulfonamides.

31VADEMECUM

CHEMOTHERAPEUTICAGENTSENROCIN® 10%

Oral solutionfor animal use Anti-infective agent

ATCVet: QJ01MA90

COMPOSITION: 1 ml of oral solution contains:Enrofloxacin 100 mg

TARGET SPECIES: Broiler chickens and fattening turkeys.

DOSAGE: The therapeutic dose of enrofloxacin is 10 mg/kg of body mass.

CONTRAINDICATIONS: Not to be used in animals with known sensitivity to enrofloxacin. Not to be used in egg laying hens.

WITHDRAWAL PERIOD: Meat of the treated poultry cannot be used for human consumption during thetreatment and 8 days after the last medicine application.

STORAGE CONDITIONS: Keep at temperatures up to +25°C, protected from light. Keep away from children.

EXPIRY DATE: 2 years. Expiry date is 28 days after the first opening. Expiry date after diluting is 24 hours.

PACKAGING: 10 ml vial in a cardboard box. 1000 ml bottle.

EFFECTS: Enrofloxacin is a chemotherapeutic agent from the wide spectrum of fluorinated quinolones group, which is active against bacteria of the genus Brucella, Bordetella, Escherichia coli, Campylobacter, Klebsiella, Corynebacterium, Listeria, Pasteurella, Proteus, Pseudomonas, Salmonella, Staphylococcus, Streptococcus, Mycoplasma, Actinobacillus, as well as all other types of microorganisms. In general, it shows stronger effect against gram-negative microorganisms.Enrofloxacin achieves bactericidal effect by inhibiting enzyme activity – DNA gyrase. Enrofloxacin and similar compounds cause rupture of cell membrane, loss of peripheral cytoplasm, deformation of cytoplasmic reticulum, and proteolysis.

INDICATIONS: Therapy of primary and secondary bacterial and mycoplasmal infections of respiratory and gastrointestinal tract in broiler chickens and fattening turkeys: CRD, coli infections, pasteurellosis, salmonellosis, staphylococcosis, infectious coryza (Haemophilus), hepatitis caused by Campylobacter spp., etc.

ADMINISTRATION: The medicine is administered perorally in the amount of 50 ml/100 l of drinking water. Therapy is conducted during 3 to 5 successive days.In case of salmonellosis, pasteurellosis, and therapy of chronical disesases, the therapy should be prolonged to at least 5 to 10 days. Enrofloxacin should always be administered in a prescribed dose (10 mg/kg). Fresh solution should be made daily. During the therapy, the poultry should not receive drinking water and should only receive water with the medicine. If the water containing the medicine was not used for 24 hours, new solution should be prepared.

ADVERSE REACTIONS: Possible damages of cartilage, if the preparation is used in chickens and poults during their intense growth and at high outdoor temperatures, when the intake of medicated water (and thus of enrofloxacin) is increased. A prolonged therapy with an increased dosage regime may cause diarrhea. Allergic reactions and photosensiti-zation reactions may occur.

ADMINISTRATION: The medicine is used mixed with feed. Mixing of the medicine with poultry’s feed should be recalcu-lated relative to the prescribed dose of enrofloxacin (10 mg/kg of body mass/day), or ENROCIN P (0.2 g/kg of body mass/day): Number of birds x average body mass in 1 kg x 0.2 = total required quantity of ENROCIN P (g)/day.

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DOSAGE: Recommended dose of enrofloxacin for pigs and calves is 2.5 – 5 mg/kg of body mass per day, and for poultry and turkey 10 mg/kg of body mass per day. The treatment is to be applied for 3 to 5 days.Pigs: 2.5 – 5 mg/kg of body mass per day (5 – 10 g of ENROCIN P per 100 kg of body mass), during 3 to 5 days. In case of salmonellosis and severe infections with complications, it is recommended to apply the dose of 5 mg/kg of body mass/day, during 5 days.Calves: 2.5 – 5 mg/kg of body mass per day (5 – 10 g of ENROCIN P per 100 kg of body mass), during 3 to 5 days. In case of salmonellosis and respiratory infections with complications, it is recommended to apply the dose of 5 mg/kg of body mass/day, during 5 days.Poultry and turkeys: 10 mg/kg of body mass, during 3 – 5 days; 5 days in case of mixed infections and chronical course of the disease.ADMINISTRATION: The medicine is used mixed with feed. Mixing of the medicine with poultry’s feed should be recalcu-lated relative to the prescribed dose of enrofloxacin (10 mg/kg of body mass/day), or ENROCIN P (0.2 g/kg of body mass/day): Number of birds x average body mass in 1 kg x 0.2 = total required quantity of ENROCIN P (g)/day.

®ENROCIN P®ENROCIN P

DOSAGE: Recommended dose of enrofloxacin for pigs and calves is 2.5 – 5 mg/kg of body mass per day, and for poultry and turkey 10 mg/kg of body mass per day. The treatment is to be applied for 3 to 5 days.Pigs: 2.5 – 5 mg/kg of body mass per day (5 – 10 g of ENROCIN P per 100 kg of body mass), during 3 to 5 days. In case of salmonellosis and severe infections with complications, it is recommended to apply the dose of 5 mg/kg of body mass/day, during 5 days.Calves: 2.5 – 5 mg/kg of body mass per day (5 – 10 g of ENROCIN P per 100 kg of body mass), during 3 to 5 days. In case of salmonellosis and respiratory infections with complications, it is recommended to apply the dose of 5 mg/kg of body mass/day, during 5 days.Poultry and turkeys: 10 mg/kg of body mass, during 3 – 5 days; 5 days in case of mixed infections and chronical course of the disease.

32VADEMECUM

ENROCIN®-POral powderfor animal use Anti-infective agent

ATCVet: QJ01MA90COMPOSITION: 1 g of oral powder contains:Enrofloxacin 50 mg

TARGET SPECIES: Pigs, calves, broiler chickens, and fattening turkeys.

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CHEMOTHERAPEUTICAGENTS

EFFECTS: Enrofloxacin is a wide-spectrum chemotherapeutic agent from the group of fluorinated quinolones, which has effect on numerous gram-positive and gram-negative microorganisms, as well as Mycoplasma spp. In general, enrofloxacin shows stronger effect against gram-negative microorganisms. Enrofloxacin achieves bactericidal effect by inhibiting enzyme activity – DNA gyrase, which is necessary to maintain DNA helical structure and its replication in bacteria cells. After the inhibition of DNA gyrase, functional disorders and cell death occur. Enrofloxacin and similar compounds cause rupture of cell membrane, peripheral loss of cytoplasm, deformation of cytoplasmic reticulum, and proteolysis. Fluoroquinolones are also active during the stationary phase of bacterial development, by changing permeability of the bacteria cell wall.

INDICATIONS: Pigs: Treatment of respiratory and gastrointestinal diseases caused by bacteria and mycoplasma sensitive to enrofloxacin (pasteurellosis, mycoplasmosis, bacterial bronchopneumonia, colibacillosis, colisepticemia, salmonellosis) and multifactorial diseases (atrophic rhinitis, enzootic pneumonia, MMA syndrome).Calves: Treatment of respiratory and gastrointestinal diseases caused by bacteria and mycoplasmasensitive to enrofloxacin (pasteurellosis, bacterial bronchopneumonia, mycoplasmosis colibacillosis) where the clinical experience and, whenever possible, the susceptibility test confirm that enrofloxacin is the medicine of choice. Broiler chickens and fattening turkeys: Treatment of infections of respiratory and gastrointestinal tracts caused by bacteria and mycoplasma sensitive to enrofloxacin (CRD, coli infections, pasteurellosis, salmonellosis, infectious coryza).

CONTRAINDICATIONS: Not to be used for prophylactic purposes. Not to be used in animals with known sensitivity to enrofloxacin. Not to be used in adult ruminants or other animal species for which the medicine is not recommended. Not to be used in egg laying hens or 14 days prior to laying. Not to be used in pregnant sows.ADVERSE REACTIONS: Fluorinated quinolones can cause arthropathy and possibly lameness in young animals (during the period of intensive growth), which occurs due to damage of the articular cartilage. Allergic reactions and photosensitiza-tion reactions may occur.NOTE: The use of enrofloxacin in combination with chloramphenicol, thiamphenicol and fluorphenicol, macrolide antibiotics and tetracyclines is not recommended due to antagonistic effect. Resorption can be reduced in cases when used simulta-neously with substances containing magnesium and/or aluminum. WITHDRAWAL PERIOD: Calves (meat and intestines): 11 daysPigs (meat and intestines): 10 daysPoultry and turkeys (meat and intestines): 5 daysThe medicine is not to be used in egg laying hens or 2 weeks prior to laying.STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.


EXPIRY DATE: Expiry date: 2 yearsExpiry date after the first opening: 7 days, at temperatures up to +25°CExpiry date after mixing with feed: 7 days, at temperatures up to +25°CExpiry date after mixing with a small quantity of feed (usage with calves): use immediately.

33VADEMECUM

CHEMOTHERAPEUTICAGENTSENROCIN®-S 5%

ATCVet: QJ01MA90COMPOSITION: 1 ml of solution for injection contains:Enrofloxacin 50 mg

TARGET SPECIES: Cattle, sheep, goats, pigs, dogs, and cats.

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Solution for injectionfor animal use Anti-infective agent

EFFECTS: Enrofloxacin is a wide-spectrum chemotherapeutic from the fluorinated quinolo-nes group, which is active against the majority of gram-negative bacteria and a large number of gram-positive bacteria (Brucella, Bordetella, Escherichia coli, Campylobacter, Klebsiella, Corynebacterium, Listeria, Pasteurella, Proteus, Pseudomonas, Salmonella, Staphylococcus, Streptococcus, Mycoplasma, Actinobacillus, as well as other types of microorganisms.) Enrofloxacin achieves bactericidal effect by inhibiting enzyme activity – DNA gyrase. After the inhibition of DNA gyrase, functional disorders and cell death occur. Resistance of bacteria to fluoroquinolones may occur as the result of chromosome mutations with consequent changes in activities of DNA gyrase, or as a result of permeabili-ty decrease for quinolones. Cross-resistance with other quinolones may occur.

INDICATIONS: Therapy of various primary and secondary infections of gastrointestinal, respiratory and genitourinary tract, skin and puerperal infections in cattle, sheep, goats, pigs, dogs, and cats.Cattle: coli diarrhea, coli septicaemia, pasteurellosis, salmonellosis, staphylococcosis, mycoplasmosis and secondary bacterial infections as a complication of viral infections.Sheep and goats: pasteurellosis, clostridiosis, gangrenous and acute mastitis, salmonellosis, mycoplasmosis, contagious footrot (with previous treatment of hoofs), etc.Pigs: coli diarrhea, coli septicaemia, pasteurellosis, salmonellosis, enzootic and bacterial bronchopneumonia, MMA syndrome, atrophic rhinitis.Dogs and cats: bacterial infections of respiratory, digestive and genitourinary tract, and skin; wound infections, inflammation of external auditory canal.

ADMINISTRATION: The medicine is administered subcutaneously (cattle, sheep, goats, dogs, and cats) and intramuscularly (pigs).

STORAGE CONDITIONS: Keep at temperatures up to +25°C, protected from light. Keep away from children.EXPIRY DATE: 2 years. Use immediately after the first opening.PACKAGING: 100 ml glass vial in a cardboard box.

CONTRAINDICATIONS: Not to be used in animals with known sensitivity to enrofloxacin. The medicine is not to be used in puppies of small and medium dog breeds up to 8 months of age, and 12 or 18 months (depending on the breed) for dogs of large breeds.ADVERSE REACTIONS: Local reactions at the point of medicine application are possible (mild tissue irritation), especial-ly when the medicine is administered in a larger quantity at a single injection point.After administering the medicine, gastrointestinal disorders (vomiting and diarrhea), skin rash, as well as animal uneasiness, may occur. Fluorinated quinolones can cause arthropathy and possibly lameness in young animals, which occurs due to damage of the articular cartilage.Also, photosensitivity is possible if treated animals are exposed to the effects of sunlight.NOTE: If animals are simultaneously treated with theophylline and enrofloxacin, convulsions may occur.The use of enrofloxacin in combination with chloramphenicol (dogs and cats), thiamphenicol and fluorphenicol, macrolide antibiotics, and tetracyclines is not recommended due to antagonistic effect. Treated animals are not to be exposed to sunlight because of adverse effects.WITHDRAWAL PERIOD:Cattle: Meat, organs, and other edible tissues: 14 daysMilk: 7 daysPigs: Meat, organs, and other edible tissues: 10 daysSheep and goats: Meat, organs, and other edible tissues: 14 daysMilk: The medicine is not to be used in lactating sheep and goats whose milk is used for human consumption.

DOSAGE: Cattle and pigs: The usual therapeutic dose of enrofloxacin is 2.5 mg per 1 kg of body mass or 1 ml of ENROCIN - S 10% per 40 kg of body mass. The medicine is administered once within 24 hours, over 3 to 5 days. In severe cases, the enrofloxacin dose can be increased up to 5 mg/kg of body mass, i.e. 1 ml of medicine per 20 kg of body mass.ADMINISTRATION: The medicine is administered subcutaneously (s.c.) and intramuscularly (i.m.) on usual places, while the medicine is administered intramuscularly to piglets in the middle of the cervical musculature.In case the medicine quantity exceeds 10 ml for calves and cattle, 5 ml for pigs, and 2.5 ml for piglets, it is necessary to apply the medicine on several places.

ADVERSE REACTIONS: Local reactions at the point of medicine application are possible, especially when the medicine is administered in a larger quantity at one injection point. After administering the medicine, gastrointestinal disorders (vomiting and diarrhea), skin rash, as well as animal uneasiness, may occur. Fluorinated quinolones can cause arthropathy and possibly lameness in young animals, which occurs due to damage of the articular cartilage. Also, photosensitivity is possible if treated animals are exposed to the effects of sunlight.

NOTE: If animals are simultaneously treated with theophylline and enrofloxacin, convulsions may occur. The use of enrofloxacin in combination with thiamphenicol and fluorphenicol, macrolide antibiotics and tetracyclines is not recommended due to antagonistic effect. Treated animals are not to be exposed to sunlight because of adverse effects.

WITHDRAWAL PERIOD:Cattle: Meat, organs, and other edible tissues: 14 daysMilk: 7 daysPigs: Meat, organs, and other edible tissues: 10 days

DOSAGE: Cattle and pigs: The usual therapeutic dose of enrofloxacin is 2.5 mg per 1 kg of body mass or 1 ml of ENROCIN - S 10% per 40 kg of body mass. The medicine is administered once within 24 hours, over 3 to 5 days. In severe cases, the enrofloxacin dose can be increased up to 5 mg/kg of body mass, i.e. 1 ml of medicine per 20 kg of body mass.ADMINISTRATION: The medicine is administered subcutaneously (s.c.) and intramuscularly (i.m.) on usual places, while the medicine is administered intramuscularly to piglets in the middle of the cervical musculature.In case the medicine quantity exceeds 10 ml for calves and cattle, 5 ml for pigs, and 2.5 ml for piglets, it is necessary to apply the medicine on several places.

ADVERSE REACTIONS: Local reactions at the point of medicine application are possible, especially when the medicine is administered in a larger quantity at one injection point. After administering the medicine, gastrointestinal disorders (vomiting and diarrhea), skin rash, as well as animal uneasiness, may occur. Fluorinated quinolones can cause arthropathy and possibly lameness in young animals, which occurs due to damage of the articular cartilage. Also, photosensitivity is possible if treated animals are exposed to the effects of sunlight.

NOTE: If animals are simultaneously treated with theophylline and enrofloxacin, convulsions may occur. The use of enrofloxacin in combination with thiamphenicol and fluorphenicol, macrolide antibiotics and tetracyclines is not recommended due to antagonistic effect. Treated animals are not to be exposed to sunlight because of adverse effects.

WITHDRAWAL PERIOD:Cattle: Meat, organs, and other edible tissues: 14 daysMilk: 7 daysPigs: Meat, organs, and other edible tissues: 10 days

34VADEMECUM

CHEMOTHERAPEUTICAGENTSENROCIN®-S 10%

ATCVet: QJ01MA90COMPOSITION: 1 ml of solution for injection contains:Enrofloxacin 100 mg

TARGET SPECIES: Cattle and pigs.

®

CONTRAINDICATIONS: Not to be used in animals with known sensitivity to enrofloxacin.


EXPIRY DATE: 2 years. Expiry date after the first opening: use immediately.


Solution for injectionfor animal use Anti-infective agent

EFFECTS: Enrofloxacin is a wide-spectrum chemotherapeutic from the fluorinated quinolones group, which is active against the majority of gram-negative bacteria and a large number of gram-positive bacteria (Brucella, Bordetella, Escherichia coli, Campylo-bacter, Klebsiella, Corynebacterium, Listeria, Pasteurella, Proteus, Pseudomonas, Salmonella, Staphylococcus, Streptococcus, Mycoplasma, Actinobacillus, as well as other types of microorganisms.) Enrofloxacin achieves bactericidal effect by inhibiting enzyme activity – DNA gyrase, which is necessary to maintain DNA helical structure and its replication in bacteria cells. After the inhibition of DNA gyrase, functional disorders and cell death occur. Fluoroquinolones are also active during the stationary phase of bacterial development, by changing permeability of the bacteria cell wall. Resistance of bacteria to fluoroquinolones may occur as the result of chromosome mutations with consequent changes in activities of DNA gyrase, or as a result of permeability decrease for quinolones. Occurrence of the “plasmid-type resistance” is extremely rare. Cross-re-sistance with other quinolones may occur.

INDICATIONS: Therapy of various primary and secondary infections of gastrointestinal, respiratory and other infections in cattle and pigs.Cattle: coli diarrhea, coli septicaemia, pasteurellosis, salmonellosis, staphylococcosis, mycoplasmosis and secondary bacterial infections as a complication of viral infections.Pigs: coli diarrhea, coli septicaemia, pasteurellosis, salmonellosis, enzootic and bacterial bronchopneumonia, MMA syndrome, atrophic rhinitis.

35VADEMECUM

FLUMEKVIN

ATCVet: QJ01MB07

COMPOSITION: 1 g of oral powder contains:Flumequine 100 mg

TARGET SPECIES: Calves, lambs, pigs, poultry (chickens), and fish.

ADMINISTRATION: The medicine is administered by adding it to feed or drinking water/milk.

Oral powderfor animal use Anti-infective agent


EFFECTS: Flumequine is an antimicrobial substance from the group of fluoroquinolones which primarily has effect on gram-negative bacteria so it is used for treatment of gastrointestinal, genitourinary and respiratory diseases. Under in vitro conditions, the following bacteria are sensitive to flumequine: Salmonella spp., Escherichia coli, Pasteurella spp., Proteus spp., Haemophilus spp. It also has effects on Yersinia pseudotuberculosis, Edwardsiella, Aerobacter, Pseudomonas, Vibrio, Cytophaga, Klebsiella, and Enterobacter species, as well as on certain gram-positive bacteria Staphylococcus spp. and Diplococcus spp. Bactericidal effect of flumequine is based on the inhibition of the DNA gyrase enzymes (topoisomerases), necessary for the replication and transcription of the bacterial DNA.

INDICATIONS: Calves, lambs and pigs – treatment of bacterial infections of digestive, respiratory (salmonellosis, colibacil-losis, and pasteurellosis) and genitourinary tract caused by microorganisms susceptible to flumequine.Poultry (chickens) – treatment of bacterial infections of digestive, respiratory (salmonellosis, colibacillosis and pasteurello-sis), and genitourinary tract caused by microorganisms susceptible to flumequine.Fish – treatment of septicemia (furunculosis, yersiniosis, vibriosis), chronical and secondary infections caused by bacteria susceptible to flumequine.

ADVERSE REACTIONS: After administering the medicine, gastrointestinal disorders may occur (transient diarrhea; nausea and vomiting in pigs), skin rash, and overexcitability of the CNS. In young animals, damage of the articular cartilage, arthropathy, and lameness may occur. Photosensitivity is also possible if treated animals are exposed to the effects of sunlight. If you notice a serious or any other adverse effect not mentioned in these instructions, please immediately notify the authorized veterinarian.NOTE: Treated animals are not to receive drinking water for 2 or 3 hours before administering the medicine in water or milk. Animals should consume the dissolved solution immediately. During the treatment period, animals must not drink water other than the medicated one. Medicated water should be made in thoroughly cleaned vessels, without leftover detergent. When mixing the medicine into feed, take care the medicine is evenly mixed.The medicine should be mixed first into a smaller quantity of feed, and then gradually mixed into the total required quantity of feed. The medicine for use in fish is prepared by first mixing pellets and the measured required quantity of the medicine, and then gradually adding edible or fish oil (for the purpose of better medicine binding) with constant mixing (approximate-ly 1 l of oil for 50 kg of pellets). Mixing is finished when all the pellets become darker and reach a uniform color. The usage of this medicine should be limited to cases in which the cause manifested resistance to other antibiotics and when bacterial confirmation of the diagnosis and cause sensitivity test justify its application.

CONTRAINDICATIONS: Not to be used in egg laying hens. Not to be used in animals with known sensitivity to flumequine.

DOSAGE: Calves and lambs: 1.8 – 2.2 g/15 kg of body mass (equivalent to 12 – 15 mg of flumequine/kg of body mass/day). The first half of the dose should be administered in the morning, and another one after 12 hours, in the evening. Treatment lasts for 5 days.Pigs: 1.5 – 2.0 g/10 kg of body mass (equivalent to 15 – 20 mg/kg of active substance/day).The first half of the dose should be administered in the morning, and another one after 12 hours, in the evening. Treatment lasts for 3 – 5 days.Poultry: Recommended dose of flumequine is 12 mg/kg of body mass/day for 3 to 5 days.Fish: Recommended dose of flumequine is 12 – 20 mg/kg of body mass/day for 5 days, i.e. 12 – 20 g/100 kg of fish. The upper recommended dose limit is indicated in chronic cases. For adult animals, the total daily dose of medicine is divided into 3 meals (it is administered in intervals of 4 – 6 hours), while for juvenile categories all daily meals must contain the medicine. The treatment lasts for 5 days, and in cases of chronic infections and at lower water temperatures, it can last longer.

36VADEMECUM

STORAGE CONDITIONS: Keep away from children. Keep at temperatures up to +25°C in original packaging.

FLUMEKVINOral powderfor animal use Anti-infective agent


WITHDRAWAL PERIOD: Poultry meat: 3 days. Pig (piglet), calves and lambs meat: 6 days. Fish meat: 80°D (degree day). Withholding period expressed in days depends on the temperature of water. At the water temperature of 5°C, the withhold-ing period is 16 days, and at the temperature of 20°C, it is only 4 days from the last medicine application.The medicine is not to be used in egg laying hens nor 4 weeks prior to laying.

EXPIRY DATE: 2 years. Expiry date after the first opening: 3 months, at temperatures up to 25°C.Expiry date after diluting in drinking water: 24 hours, at temperatures up to 25°C. Expiry date after diluting in milk: use immediately. Expiry date after mixing with feed: use immediately.Do not use the medicine after the date indicated on the packaging.

PACKAGING: 1x100 g: Triplex foil bag (polyester/aluminum foil/polyethylene) with 100 g of powder.1x1 kg: Inner packaging: polyethylene bag with 1 kg of powder. Outer packaging: cardboard folding box with a bag of 1 kg of powder and Instructions for the medicine.

ADVERSE REACTIONS: Swelling may occur at the injection point. The most frequently recorded adverse effects of levamisole in cattle are: frothy nasal discharge, hypersalivation, excitedness or tremor, licking, and head jolting. In sheep, levamisole may cause transient excitedness. In pigs, levamisole may cause increased salivation or emergence of forthy nasal discharge. In pigs infected by pulmonary nematodes, coughing or vomiting may occur. These adverse effects are of transient character and mainly occur after administering a greater dose of medicine than recommended.

NOTE: Since the preparation has no ovicide effect, immediately after administering the medicine, animals’ excrement should be safely removed or the herd/flock must be relocated to a “non-infested” pasture. If a hypersensitive reaction appears, the treatment should be suspended, followed by administration of adrenaline, and, when required, antihistamines and glucocorticoids.

EFFECTS: Levamisole Hydrochloride is an anthelmintic with a wide spectrum of anti-nematode activity. It is efficient in treating adult and larval forms of parasites in respiratory and gastrointestinal animal tract. In cattle and sheep, efficiency of levamisole exceeds 98% against adult gastrointestinal strongyles: Bunostomum, Chabertia ovina, Cooperia, Haemonchus, Nematodirus, Oesophagostomum, Ostertagia, Strongyloides, Trychostrongylus, and against pulmonary parasites: Protostrongylus rufescens and Dictyocaulus species. Gastrointestinal parasites are eliminated mostly within the first 24 hours, and pulmonary parasites within the first 12 hours, after administering levamisole.

ADVERSE REACTIONS: Swelling may occur at the injection point. The most frequently recorded adverse effects of levamisole in cattle are: frothy nasal discharge, hypersalivation, excitedness or tremor, licking, and head jolting. In sheep, levamisole may cause transient excitedness. In pigs, levamisole may cause increased salivation or emergence of forthy nasal discharge. In pigs infected by pulmonary nematodes, coughing or vomiting may occur. These adverse effects are of transient character and mainly occur after administering a greater dose of medicine than recommended.

NOTE: Since the preparation has no ovicide effect, immediately after administering the medicine, animals’ excrement should be safely removed or the herd/flock must be relocated to a “non-infested” pasture. If a hypersensitive reaction appears, the treatment should be suspended, followed by administration of adrenaline, and, when required, antihistamines and glucocorticoids.

EFFECTS: Levamisole Hydrochloride is an anthelmintic with a wide spectrum of anti-nematode activity. It is efficient in treating adult and larval forms of parasites in respiratory and gastrointestinal animal tract. In cattle and sheep, efficiency of levamisole exceeds 98% against adult gastrointestinal strongyles: Bunostomum, Chabertia ovina, Cooperia, Haemonchus, Nematodirus, Oesophagostomum, Ostertagia, Strongyloides, Trychostrongylus, and against pulmonary parasites: Protostrongylus rufescens and Dictyocaulus species. Gastrointestinal parasites are eliminated mostly within the first 24 hours, and pulmonary parasites within the first 12 hours, after administering levamisole.

37VADEMECUM

ANTHELMINTICSHELMIZOL®-S

ATCVet: QP52AE01

COMPOSITION: 1 ml of solution for injection contains:Levamisole Hydrochloride 75 mg

TARGET SPECIES: Cattle, sheep, and pigs.

DOSAGE: The preparation is to be administered in the following dose or quantity, as specified for:Cattle: 10 ml/100 kg of body mass (equivalent to 7.5 mg/kg of body mass of levamisole)Sheep: 1 ml/10 kg of body mass (equivalent to 7.5 mg/kg of body mass of levamisole)Pigs: 1 ml/10 kg of body mass or 10 ml/100 ml per 1 kg of body mass (equivalent to 7.5 mg/kg of body mass oflevamisole)

WITHDRAWAL PERIOD: Meat and edible tissues: 28 days. The medicine is not to be used in cows andsheep whose milk is used for human consumption.STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children. EXPIRY DATE: Expiry date: 3 years. Expiry date after the first opening: 28 days, at temperatures up to +25°C. Do not use the medicine after the date indicated on the packaging.


Solution for injectionfor animal use Anthelmintic

INDICATIONS: In cattle and sheep: gastrointestinal nematodes: Haemonchus spp., Trychostrongylus spp., Oesophagosto-mum spp., Nematodirus spp., Bunostomum spp., Chabertia ovina, Strongyloides papillosus, Cooperia spp. Pulmonary nematodes: Dictyocaulus spp.In pigs: Ascaris suum and “Larva migrans”, Strongyloides ransomi, Trichuris suis, Oesophagostomum spp., Hyostrongylus rubidus, and Metastrongylus spp.The preparation has effect on both adult and larval forms of parasites.

ADMINISTRATION: The medicine is administered subcutaneously (s.c.) to cattle and sheep, and intramuscularly (i.m.) to pigs. In case of applying a greater quantity of medicine, due to possible local reaction, maximum 20 ml in cattle, 10 ml in pigs, and 5 ml in sheep should be applied at a single injection point.CONTRAINDICATIONS: The medicine is not to be used in animals hypersensitive to levamisole. Also, the preparation is not to be applied neither simultaneously nor 14 days before or after administering organophosphorous, carbamic compounds or compounds similar to nicotine (in effect), such as: diethylcarbamazine citrate, pyrantel, and morantel. The application of the preparation in cachectic and exhausted animals, animals under stress (due to vaccination or castration), and in animals with severe renal and liver injury is not recommended. The preparation is contraindicated in lactating cows and sheep, whose milk is used for human consumption.

CONTRAINDICATIONS: Not to be used in animal species for which it is not indicated, because it may cause serious disorders, even death. Not to be used in animals with known hypersensitivity to ivermectin.ADVERSE REACTIONS: No adverse effects in target animals have been identified after peroral application.

ADMINISTRATION: The medicine is used mixed with feed. After mixing the medicine in the feed, it is administered to pigs in the growing phase (body mass up to and above 40 kg), as the only meal constantly for seven days, while it is administered to adult pigs in the quantity of 1 kg of prepared mixture /100 kg of body mass per day.In order to achieve full control of parasite infections, it may be necessary to repeat the treatment using this medicine after 21 days following the initial treatment termination.Pregnant sows should be treated for 14 to 21 days before farrowing, in order to reduce the possibility of piglet infection.For successful treatment, the medicine must be thoroughly mixed into the feed for better homogenization, so that each animal receives an appropriate medicine dose. Therefore, it is best to mix the medicine into a smaller amount of feed first, and then into the intended total amount of feed.

INDICATIONS: Treatment and control of parasite infections caused by the following endoparasites and ectoparasites: Gastrointestinal nematodes (adult and the 4th stadium of larva): Ascaris suum, Hyostrongylus rubidus, Oesophagostomum spp., Strongyloides ransomi (adult and somatic larva shapes). Pulmonary nematodes (adult): Metastrongylus spp. Lice: Haematopinus suis. Mange mites: Sarcoptes scabiei var. suis.DOSAGE: Peroral treatment dose per day for pigs is: 0.5 g of medicine per 10 kg of body mass.The treatment lasts for 7 successive days.Pigs weighing up to 40 kg: 1 kg/1 ton of feed, i.e. 100 g/100 kg of feed.Pigs weighing above 40 kg: 1.2 kg/1 ton of feed, i.e. 120 g/100 kg of feed.Sows and boars, adult pigs: 5 kg/1 ton of feed, i.e. 500 g/100 kg of feed

EFFECTS: Ivermectin is an antiparasitic agent, synthetic derivative of abamectin, and it belongs to the group of macrocyclic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high affinity, they bind to glutamate-gat-ed chloride channels in invertebrate nerve and muscle cells. This leads to increased permea-bility of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Ivermectin has effect against adult and larva shapes (4th stadium) of nematodes and arthropods. Safety of this group of compounds is based on the fact that mammals do not have glutamate-gated chloride channels, that macrocyclic lactones have low affinity for other ligand-gated ionic channels, and on the fact that they do not penetrate the blood-brain barrier of mammals, except in some dog species.

CONTRAINDICATIONS: Not to be used in animal species for which it is not indicated, because it may cause serious disorders, even death. Not to be used in animals with known hypersensitivity to ivermectin.ADVERSE REACTIONS: No adverse effects in target animals have been identified after peroral application.

ADMINISTRATION: The medicine is used mixed with feed. After mixing the medicine in the feed, it is administered to pigs in the growing phase (body mass up to and above 40 kg), as the only meal constantly for seven days, while it is administered to adult pigs in the quantity of 1 kg of prepared mixture /100 kg of body mass per day.In order to achieve full control of parasite infections, it may be necessary to repeat the treatment using this medicine after 21 days following the initial treatment termination.Pregnant sows should be treated for 14 to 21 days before farrowing, in order to reduce the possibility of piglet infection.For successful treatment, the medicine must be thoroughly mixed into the feed for better homogenization, so that each animal receives an appropriate medicine dose. Therefore, it is best to mix the medicine into a smaller amount of feed first, and then into the intended total amount of feed.

INDICATIONS: Treatment and control of parasite infections caused by the following endoparasites and ectoparasites: Gastrointestinal nematodes (adult and the 4th stadium of larva): Ascaris suum, Hyostrongylus rubidus, Oesophagostomum spp., Strongyloides ransomi (adult and somatic larva shapes). Pulmonary nematodes (adult): Metastrongylus spp. Lice: Haematopinus suis. Mange mites: Sarcoptes scabiei var. suis.DOSAGE: Peroral treatment dose per day for pigs is: 0.5 g of medicine per 10 kg of body mass.The treatment lasts for 7 successive days.Pigs weighing up to 40 kg: 1 kg/1 ton of feed, i.e. 100 g/100 kg of feed.Pigs weighing above 40 kg: 1.2 kg/1 ton of feed, i.e. 120 g/100 kg of feed.Sows and boars, adult pigs: 5 kg/1 ton of feed, i.e. 500 g/100 kg of feed

EFFECTS: Ivermectin is an antiparasitic agent, synthetic derivative of abamectin, and it belongs to the group of macrocyclic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high affinity, they bind to glutamate-gated chloride channels in invertebrate nerve and muscle cells. This leads to increased permeability of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Ivermectin has effect against adult and larva shapes (4th stadium) of nematodes and arthropods. Safety of this group of compounds is based on the fact that mammals do not have glutamate-gated chloride channels, that macrocyclic lactones have low affinity for other ligand-gated ionic channels, and on the fact that they do not penetrate the blood-brain barrier of mammals, except in some dog species.

38VADEMECUM

ANTHELMINTICSIVERMEKTIN-P

ATCVet: QP54AA01COMPOSITION: 1 g of premix for medicated feed contains:Ivermectin 2 mg


WITHDRAWAL PERIOD: Pigs (meat and intestines): 12 days.STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.EXPIRY DATE: Expiry date: 2 yearsExpiry date after the first opening: 7 days, at temperatures up to +25°C.Use immediately after mixing with feed. Do not use the medicine after the date indicated on the packagingPACKAGING: 100 g bag and 1 kg bag (in a cardboard box).

Premix for medicated feed for animal use Anthelmintic

Ivermectin is an antiparasitic agent, synthetic derivative of abamectin, and it belongs to the group of macrocyclic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high affinity, they bind to glutamate-gat-ed chloride channels in invertebrate nerve and muscle cells. This leads to increased permea-bility of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Ivermectin has effect against adult and larva shapes (4th stadium) of nematodes and arthropods. Safety of this group of compounds is based on the fact that mammals do not have glutamate-gated chloride channels, that macrocyclic lactones have low affinity for other ligand-gated ionic channels, and

NOTE: Contact between treated pigs and infected animals, contaminated objects or land may cause reinfection. Contact between treated and untreated animals should be prevented for at least 7 days following the treatment completion. For the purpose of preventing development of resistance which may lead to decrease in efficiency or lack of treatment efficiency, the following should be avoided:– Too frequent and repeated use of anthelmintics from the same group over a longer period of time– Sub-dosage, which may happen due to wrong estimate of body mass, wrong manner of medicine administration or usage of an uncalibrated doser.Clinical cases of doubt regarding development of resistance to anthelmintics should be confirmed by appropriate tests (e.g. the Fecal Egg Count Reduction Test). If the results indicate the development of resistance to a certain anthelmintic, an anthelmintic of a different class, that is, with a different mechanism of effect, should be used in the treatment.

INDICATIONS: Treatment of parasitic diseases caused by gastrointestinal and pulmonary nematodes, as well as skin parasites.Cattle: Gastrointestinal nematodes (adult and the 4th stadium of larva): Haemonchus placei, Bunostomum phlebotomum,Oesophagostomum radiatum, Trichostrongylus axei, Nematodirus spp., Osertagia spp., Cooperia spp.; Pulmonary nematodes (adult and the 4th stadium of larva): Dictyocaulus viviparus; Other helminths: Parafilaria bovicola; Lice: Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus; Mange mites: Sarcoptes scabiei var. bovis, Psoropt-es equi var. bovis, Chorioptes bovis var. Bovis; Ticks: Boophilus microplus, B. decoloratus, Ornithodorus savigny; Botfly: Hypoderma bovis, Hypoderma lineatum; Flies: Chrysomia bezzianaSheep: Gastrointestinal nematodes (adult and the 4th stadium of larva): Haemonchus contortus, Chabertia ovina, Osterta-gia spp., Trichostrongylus spp. (adult), Nematodirus spp., Oesophagostomum spp. (adult), Trichuris ovis (adult); Pulmonary nematodes: Dictyocaulus filaria, Protostrongylus rufescens; Mange mites: Sarcoptes scabiei var. ovis, Psoroptes equi var. Ovis; Botfly: Oestrus ovis (all larva shapes)Pigs: Gastrointestinal nematodes (adult and the 4th stadium of larva): Ascaris suum, Hyostrongylus rubidus,Oesophagostomum spp., Strongyloides ransomi (adult and somatic larva shapes); Pulmonary nematodes: (adult): Metastrongylus spp.; Lice: Haematopinus suis; Mange mites: Sarcoptes scabiei var. suis

EFFECTS: Ivermectin is an antiparasitic agent, synthetic derivative of abamectin, and it belongs to the group of macrocy-clic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high affinity, they bind to glutamate-gated chloride channels in invertebrate nerve and muscle cells. This leads to increased permeability of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Compounds of this group are also agonists for GABA receptors.

INDICATIONS: Treatment of parasitic diseases caused by gastrointestinal and pulmonary nematodes, as well as skin parasites.Cattle: Gastrointestinal nematodes (adult and the 4th stadium of larva): Haemonchus placei, Bunostomum phlebotomum,Oesophagostomum radiatum, Trichostrongylus axei, Nematodirus spp., Osertagia spp., Cooperia spp.; Pulmonary nematodes (adult and the 4th stadium of larva): Dictyocaulus viviparus; Other helminths: Parafilaria bovicola; Lice: Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus; Mange mites: Sarcoptes scabiei var. bovis, Psoropt-es equi var. bovis, Chorioptes bovis var. Bovis; Ticks: Boophilus microplus, B. decoloratus, Ornithodorus savigny; Botfly: Hypoderma bovis, Hypoderma lineatum; Flies: Chrysomia bezzianaSheep: Gastrointestinal nematodes (adult and the 4th stadium of larva): Haemonchus contortus, Chabertia ovina, Osterta-gia spp., Trichostrongylus spp. (adult), Nematodirus spp., Oesophagostomum spp. (adult), Trichuris ovis (adult); Pulmonary nematodes: Dictyocaulus filaria, Protostrongylus rufescens; Mange mites: Sarcoptes scabiei var. ovis, Psoroptes equi var. Ovis; Botfly: Oestrus ovis (all larva shapes)Pigs: Gastrointestinal nematodes (adult and the 4th stadium of larva): Ascaris suum, Hyostrongylus rubidus,Oesophagostomum spp., Strongyloides ransomi (adult and somatic larva shapes); Pulmonary nematodes: (adult): Metastrongylus spp.; Lice: Haematopinus suis; Mange mites: Sarcoptes scabiei var. suis

EFFECTS: Ivermectin is an antiparasitic agent, synthetic derivative of abamectin, and it belongs to the group of macrocy-clic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high affinity, they bind to glutamate-gated chloride channels in invertebrate nerve and muscle cells. This leads to increased permeability of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Compounds of this group are also agonists for GABA receptors.

39VADEMECUM

ANTHELMINTICSIVERMEKTIN-S

ATCVet: QP54AA01

COMPOSITION: 1 ml of solution for injection contains: Ivermectin 10 mg

TARGET SPECIES: Cattle, sheep, and pigs.

DOSAGE: The medicine is administered in the following quantities, i.e. doses: Cattle: 1 ml of medicine per 50 kg of body mass (0.2 mg of ivermectin per 1 kg of body mass).Sheep: 0.5 ml of medicine per 25 kg of body mass (0.2 mg of ivermectin per 1 kg of body mass). Pigs: 1 ml of medicine per 33 kg of body mass (0.3 mg of ivermectin per 1 kg of body mass).

Solution for injectionfor animal use Anthelmintic

Ivermectin is an antiparasitic agent, synthetic

clic lactones. Compounds of this class have unified effect on endoparasites and ectoparasites. Selectively and with high

invertebrate nerve and muscle cells. This leads to increased permeability of the cell membrane to chloride ions with accompanying hyperpolarization of nerve and muscle cells, which results in paralysis and death of the parasite. Compounds

ADMINISTRATION: The medicine is administered subcutaneously (s.c.) one time only, preferably into the wrinkled skin on the neck, in front of or behind cattle’s shoulder blade, or subcutaneously into the neck of sheep and pigs.Cattle: Maximum 10 ml of medicine should be applied at one injection point.Sheep: During the treatment of sheep mange, the medicine should be administered twice, with a 7-day interval. Contact between treated and untreated animals should be prevented for at least 7 days following the treatment completion.CONTRAINDICATIONS: Not to be used in animal species for which it is not indicated, because it may cause serious disorders, even death. Not to be used in animals with known hypersensitivity to ivermectin.The medicine is not to be administered intravenously or intramuscularly.ADVERSE REACTIONS: Subcutaneous application may sometimes be followed by a painful reaction in sheep, and also by swelling in cattle. These reactions disappear spontaneously.

They increase the release of GABA and binding to GABAergic receptors in synaptosomes of the nerve system, which leads to activation of receptor ionic channels in the neuron’s cell membrane, hyperpolarization of the neuron’s cell membrane, and inhibition of neurotransmission, i.e. paralysis. Ivermectin has effect against adult and larva shapes (4th stadium) of nematodes and arthropods. Safety of this group of compounds is based on the fact that mammals do not have glutamate-gated chloride channels, that macrocyclic lactones have low affinity for other ligand-gated ionic channels, and on the fact that they do not penetrate the blood-brain barrier of mammals, except in some dog species.

NOTE: Not to be used in lactating cows whose milk is used for human consumption, nor in cows and heifers in the gestation period at least 60 days before calving.Not to be used in lactating sheep whose milk is used for human consumption, nor in sheep in the gestation period at least 60 days before lambing.Pigs: Besides regular dehelminthization, it is recommended to administer this preparation to boars twice a year, to sows one or two weeks before farrowing, and to gilts one or two weeks before mating and farrowing. Newly-arrived animals should be treated and isolated for 7 – 10 days before mixing with other animals. All fatlings should be treated before accommodating them into the facilities for fattening. Piglets in the postnatal period may be especially sensitive to the effects of ivermectin.WITHDRAWAL PERIOD: Cattle (meat and intestines): 49 daysSheep (meat and intestines): 42 daysPigs (meat and intestines): 28 daysSheep and cattle (milk): Not to be used in lactating sheep and cattle whose milk is used for human consumption. Not to be used in gestating sheep, cows and heifers at least 60 days before lambing or calving

NOTE: Not to be used in lactating cows whose milk is used for human consumption, nor in cows and heifers in the gestation period at least 60 days before calving.Not to be used in lactating sheep whose milk is used for human consumption, nor in sheep in the gestation period at least 60 days before lambing.Pigs: Besides regular dehelminthization, it is recommended to administer this preparation to boars twice a year, to sows one or two weeks before farrowing, and to gilts one or two weeks before mating and farrowing. Newly-arrived animals should be treated and isolated for 7 – 10 days before mixing with other animals. All fatlings should be treated before accommodating them into the facilities for fattening. Piglets in the postnatal period may be especially sensitive to the effects of ivermectin.WITHDRAWAL PERIOD: Cattle (meat and intestines): 49 daysSheep (meat and intestines): 42 daysPigs (meat and intestines): 28 daysSheep and cattle (milk): Not to be used in lactating sheep and cattle whose milk is used for human consumption. Not to be used in gestating sheep, cows and heifers at least 60 days before lambing or calving

40VADEMECUM

STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.EXPIRY DATE: 2 years. Expiry date after opening: use immediately.PACKAGING: 30 ml glass vial in a cardboard box. 100 ml glass vial in a cardboard box.

ANTHELMINTICSIVERMEKTIN-SSolution for injectionfor animal use Anthelmintic

NOTE: Adhere to the determined precaution measures when using the medicine. The prepared dilution of the medicine should be used on the same day. Do not exceed the prescribed medicine concentration. Animals treated with this medicine are not to be given any other medicine from this group of organophosphates, nor levamisole for at least two weeks. The medicine is not to be used in animals in gestation. It is not to be used in lactating sheep whose milk is used for human consumption. The person administering the preparation must wear protective clothing (waterproof coat, apron), footwear (rubber boots), gloves (PVC, rubber), and goggles. Wear a protective mask while administering the preparation. After use, wash the protective footwear and clothing thoroughly. Do not eat, drink, nor smoke during animal treatment.After administering the medicine, wash your hands with running water. In case of accidental contamination of skin or eyes with the concentrate, wash immediately with running water. After accidental poisoning, seek medical help and bring the label of the preparation with you. Symptoms of poisoning in people are headache, weakness, disorientation, blurred vision, increased salivation and sweating, stomach convulsions, diarrhea, miosis, and increased secretion of bronchial glands. Symptoms usually appear within 24 h from diazinon exposure..

CONTRAINDICATIONS: The preparation is not to be used in calves younger than 8 weeks, +lambs and kid goats younger than 6 weeks, and piglets younger than 4 weeks. Puppies younger than 12 weeks also must not be treated. It is not to be used in sick, weak and exhausted animals, as well as in animal species for which the medicine is not recommended. Not to be used in thirsty animals.

ADMINISTRATION: It is to be used externally by bathing, sprinkling or washing as water emulsion. Since animals, when bathing in pools, always carry out on their bodies a certain volume of the solution (up to 10%), the solution should be added and intensified by pouring 35 ml of preparation per each 10 ml of water that is added. Animals must be provided with water before each treatment! Sheep should spend one minute in the bath with two divings as mandatory. Sprinkling is administered by a sprinkler. The whole animal should be sprinkled, until it becomes wet. The required quantity for one animal is 1 – 5 l of the emulsion, depending on the animal size. The frequency of treatment application depends on the parasite type, life cycle and climate factors. Ticks are suppressed twice in a 20-day interval. Treatment against lice should be repeated after 17 days. Mange is suppressed within minimum three treatments in a 10-day interval. In addition, it is required to treat cleaned barns, pens and accessories using the emulsion with the concentration of 100 ml of preparation per 1 l of water

EFFECTS: Diazinon is an organophosphorous ecto-antiparasitic which is efficient against various types of ectoparasites and insects. It is efficient (98 – 100%) against fleas, lice, mange mites, ticks, and flies in domestic animals, dogs and cats. In horses and cattle, it is efficient against lice (Anoplura, Mallophaga) and mange mites (Sarcoptes, Psoroptres, Chorioptes) and larva shapes (22 – 26 days), Ripicephalus sanguineus. In small ruminants, diazinon is efficient against all types of mange mites (Sarcoptes, Psoroptres, Chorioptes), ticks (Ixodidae), lice (Anoplura). In pigs, diazinon is efficient against mange mites (Sarcopt-es) and lice (Anoplura), in dogs against ticks (Ripicephalus sanguineus) Dermacentor variabilis and Amblyomma americanus, mange mites (Sarcoptes, Notoedres, Otodectes), and fleas. As well as other organophosphates, diazinon inhibits the activity of acetylcholin-esterase and cholinesterase in an organism.

NOTE: Adhere to the determined precaution measures when using the medicine. The prepared dilution of the medicine should be used on the same day. Do not exceed the prescribed medicine concentration. Animals treated with this medicine are not to be given any other medicine from this group of organophosphates, nor levamisole for at least two weeks. The medicine is not to be used in animals in gestation. It is not to be used in lactating sheep whose milk is used for human consumption. The person administering the preparation must wear protective clothing (waterproof coat, apron), footwear (rubber boots), gloves (PVC, rubber), and goggles. Wear a protective mask while administering the preparation. After use, wash the protective footwear and clothing thoroughly. Do not eat, drink, nor smoke during animal treatment.After administering the medicine, wash your hands with running water. In case of accidental contamination of skin or eyes with the concentrate, wash immediately with running water. After accidental poisoning, seek medical help and bring the label of the preparation with you. Symptoms of poisoning in people are headache, weakness, disorientation, blurred vision, increased salivation and sweating, stomach convulsions, diarrhea, miosis, and increased secretion of bronchial glands.Symptoms usually appear within 24 h from diazinon exposure..

CONTRAINDICATIONS: The preparation is not to be used in calves younger than 8 weeks, +lambs and kid goats younger than 6 weeks, and piglets younger than 4 weeks. Puppies younger than 12 weeks also must not be treated. It is not to be used in sick, weak and exhausted animals, as well as in animal species for which the medicine is not recommended. Not to be used in thirsty animals.

ADMINISTRATION: It is to be used externally by bathing, sprinkling or washing as water emulsion. Since animals, when bathing in pools, always carry out on their bodies a certain volume of the solution (up to 10%), the solution should be added and intensified by pouring 35 ml of preparation per each 10 ml of water that is added. Animals must be provided with water before each treatment! Sheep should spend one minute in the bath with two divings as mandatory. Sprinkling is administered by a sprinkler. The whole animal should be sprinkled, until it becomes wet. The required quantity for one animal is 1 – 5 l of the emulsion, depending on the animal size. The frequency of treatment application depends on the parasite type, life cycle and climate factors. Ticks are suppressed twice in a 20-day interval. Treatment against lice should be repeated after 17 days. Mange is suppressed within minimum three treatments in a 10-day interval. In addition, it is required to treat cleaned barns, pens and accessories using the emulsion with the concentration of 100 ml of preparation per 1 l of water

EFFECTS: Diazinon is an organophosphorous ecto-antiparasitic which is efficient against various types of ectoparasites and insects. It is efficient (98 – 100%) against fleas, lice, mange mites, ticks, and flies in domestic animals, dogs and cats. In horses and cattle, it is efficient against lice (Anoplura, Mallophaga) and mange mites (Sarcoptes, Psoroptres, Chorioptes) and larva shapes (22 – 26 days), Ripicephalus sanguineus. In small ruminants, diazinon is efficient against all types of mange mites (Sarcoptes, Psoroptres, Chorioptes), ticks (Ixodidae), lice (Anoplura). In pigs, diazinon is efficient against mange mites (Sarcopt-es) and lice (Anoplura), in dogs against ticks (Ripicephalus sanguineus) Dermacentor variabilis and Amblyomma americanus, mange mites (Sarcoptes, Notoedres, Otodectes), and fleas. As well as other organophosphates, diazinon inhibits the activity of acetylcholin-esterase and cholinesterase in an organism.

41VADEMECUM

ECTO-ANTIPARASITICSEKTANON®

ATCVet: QP53AF03

COMPOSITION: 1 ml of the solution for external use contains:Diazinon 250 mg

TARGET SPECIES: Horses, cattle, sheep, goats, pigs, and dogs.

DOSAGE: The preparation is to be used in the following concentrations:Cattle, horses, and dogs: 1:400 (i.e. 2.5 ml/l of water)Goats and pigs: 1:1000 (i.e. 1 ml/l of water)Sheep: 1:1000 (i.e. 100 ml/100 l of water) 20 days after shearing.

Concentrate for bath emulsionfor animal use Ecto-antiparasitic

INDICATIONS: The preparation is intended for destruction of numerous ectoparasites which live as parasites in domestic animals. In horses and cattle: ticks (lxodidae), mange mites (Sarcoptes, Psoroptes, Chorioptes), lice (Anoplura, Malloplura, Mallopphaga), and flies (Brachycera). Sheep and goats: mange mites (Sarcoptes, Psoroptes, Chorioptes), ticks (Ixodidae), lice (Anoplura). Pigs: lice (Anoplura) and mange mites (Sarcoptes). Dogs: ticks (Ixodidae), fleas (Ctenocephalides canis), and mange (Sarcoptes, Notoedres, Otodectes).

ADVERSE REACTIONS: Diazinon may cause hypersalivation, skeletal muscle tremor, labored breathing,hypersensitivity to external stimuli, coordination disorder, and diarrhea.

42VADEMECUM

ECTO-ANTIPARASITICSEKTANON®

Concentrate for bath emulsionfor animal use Ecto-antiparasitic

If poisoning symptoms are severe, the poisoned person should be placed in the National Poison Control Center (Military Medical Academy).WITHDRAWAL PERIOD: The meat of treated animals is not for human consumption 35 days upon treatment. The milk of treated animals is not used for human consumption.

STORAGE CONDITIONS: Keep at temperatures up to +25°C, protected from light. Keep away from children.

EXPIRY DATE: 3 years. The medicine is to be used immediately after the first opening. The prepared dilution of the medicine should be used on the same day. Do not use the medicine after the date indicated on the packaging.

PACKAGING: 100 ml PET vial. 1 l PET vial.

INDICATIONS: The application of NOVPIRON is indicated in the following cases: The medicine is used for alleviation and elimination of pain and spasms, such as horse colic, gastrointestinal meteorism (gas colic), colic caused by tonic intestinal spasm, in small intestine obstipation, esophageal obstruction, horses’ lumbago, extremely painful wounds and injuries. The medicine is used in acute inflammatory processes of the locomotory apparatus (arthritis, bursitis, tendonitis, and myositis). The medicine is used for reduction of pain during examination of animals, that is, diagnostic painful procedures.

ADMINISTRATION: The medicine is to be administered by intramuscular or intravenous injection. In horses, slow intravenous application of the pre-tempered medicine is recommended, whereas in cattle, foals, and dogs the intramuscular and intravenous application is recommended. At one injection point, the maximum amount of medicine that can be administered (intramuscularly) to cattle is 10 ml, to foals 5 ml, and to dogs 1 – 2 ml of medicine. In severe colicky pain, intravenous or combined application of the medicine is recommended. Due to insufficiently known incompatibilities, metamizole is not to be mixed in the same syringe with other medicines.

DOSAGE: Medicine quantity for intravenous and intramuscular application:Horses, cattle: 10 – 20 ml per animal Foals (by weight): 5 – 10 ml per animal Dogs: 0.25 ml for 4.5 kg of body massThe recommended dose is to be administered once a day, but in severe cases can be repeated after 8 hours. The treatment is to be repeated for 5 days.

EFFECTS: Metamizole sodium has an analgetic, antipyretic, and spasmolytic effect which is especially expressed in the smooth musculature of the gastrointestinal tract, in both large and small animals. However, it seems that metamizole sodium has no effect on enhanced spontaneous intestinal motility nor on the spasms caused by nervous stimulation, cholinergic medicines, ganglion-stimulating medicines, histamine, or morphine.In contrast to this, metamizole sodium eliminates intestinal spasm caused by bradykinin.

INDICATIONS: The application of NOVPIRON is indicated in the following cases: The medicine is used for alleviation and elimination of pain and spasms, such as horse colic, gastrointestinal meteorism (gas colic), colic caused by tonic intestinal spasm, in small intestine obstipation, esophageal obstruction, horses’ lumbago, extremely painful wounds and injuries. The medicine is used in acute inflammatory processes of the locomotory apparatus (arthritis, bursitis, tendonitis, and myositis). The medicine is used for reduction of pain during examination of animals, that is, diagnostic painful procedures.

ADMINISTRATION: The medicine is to be administered by intramuscular or intravenous injection. In horses, slow intravenous application of the pre-tempered medicine is recommended, whereas in cattle, foals, and dogs the intramuscular and intravenous application is recommended. At one injection point, the maximum amount of medicine that can be administered (intramuscularly) to cattle is 10 ml, to foals 5 ml, and to dogs 1 – 2 ml of medicine. In severe colicky pain, intravenous or combined application of the medicine is recommended. Due to insufficiently known incompatibilities, metamizole is not to be mixed in the same syringe with other medicines.

DOSAGE: Medicine quantity for intravenous and intramuscular application:Horses, cattle: 10 – 20 ml per animal Foals (by weight): 5 – 10 ml per animalDogs: 0.25 ml for 4.5 kg of body massThe recommended dose is to be administered once a day, but in severe cases can be repeated after 8 hours. The treatment is to be repeated for 5 days.

EFFECTS: Metamizole sodium has an analgetic, antipyretic, and spasmolytic effect which is especially expressed in the smooth musculature of the gastrointestinal tract, in both large and small animals. However, it seems that metamizole sodium has no effect on enhanced spontaneous intestinal motility nor on the spasms caused by nervous stimulation, cholinergic medicines, ganglion-stimulating medicines, histamine, or morphine.In contrast to this, metamizole sodium eliminates intestinal spasm caused by bradykinin.

43VADEMECUM

ANALGOANTIPYRETICSNOVPIRON®

ATCVet: QN02BB02COMPOSITION: 1 ml of solution for injection contains:Metamizole sodium 500 mg

TARGET SPECIES: Horses, cattle, foals, dogs.

®

PACKAGING: Glass vial with 50 ml of solution for injection.

Solution for injection,for animal useAnalgoantipyretic

Like other non-steroidal anti-inflammatory medicines, metamizole sodium also acts by inhibiting the cyclooxygenase enzyme and biosynthesis of prostaglandin E2, which is responsible for the increased production of heat, and thus lowers increased body temperature. Antispasmodic effect probably occurs by blocking the effects of bradykinin.

CONTRAINDICATIONS: The medicine is not to be used in animals with diseased kidneys, liver, heart, and changed blood count. It is not to be used in case of gastroenteritis, in case of bleeding regardless of the cause, in case of dehydrated and exhausted animals. It is not to be used in racehorses at least 5 days before a race. The medicine is not to be used in animals with diagnosed ulcers on the mucous membrane of the stomach and intestines, in animals hypersensitive to this medicine, nor immediately before and after surgical intervention. The medicine is not to be used in puppies younger than 6 weeks, nor horses intended for human consumption.ADVERSE REACTIONS: Prolonged use of metamizole causes agranulocytosis, leukopenia, ulcerative gastroenteritis, vomiting, bleeding, renal and liver dysfunction. Painful reaction and swelling may occur after intramuscular application of the medicine.

WITHDRAWAL PERIOD: Cattle (meat, intestines, and other edible tissues): 12 days. Cattle (milk): 50 days. The medicine is not to be used in horses intended for human consumption.STORAGE CONDITIONS: Keep the medicine at temperatures up to +25°C in original packaging for the purposes of protection from light.Keep away from children.EXPIRY DATE: 3 years. Expiry date after first opening: 28 days, storing at temperatures up to +25°C.Do not use the medicine after the date indicated on the packaging.

NOTE: The medicine is not to be used in racehorses at least 5 days before a race. Avoid using in dehydrated, hypovolemic, and hypotensive animals to prevent possible nephrotoxic effects. Rapid intravenous application leads to hypertension and uncoordinated movements, therefore slow application is required. If the medicine is administered paravenously, tissue irritation may occur, which can lead to necrosis. The medicine is not to be administered simultaneously, nor in the course of 24 hours, with any non-steroidal, anti-inflammatory medicine, and glucocorticoids. It is not to be used with aminoglyco-side antibiotics and other potential nephrotoxic medicines. Overdose of the preparation causes convulsions and ataxia resulting from the stimulation of the CNS.

Caffeine stimulates the central nervous system (CNS). Higher doses of caffeine cause a stronger central stimulation, manifesting restlessness, tremor and hyperesthesia. Very large doses can cause generalized convulsions. Caffeine stimulates respiratory, vasomotor, and vagal center in the medulla oblongata. Caffeine has a stimulating effect on the cardiovascular system. This effect is primarily manifested as positive inotropic and positive chronotropic effect. Under the influence of caffeine, the heart rate and cardiac output increase. Applied in high enough doses, caffeine causes the relaxation of smooth muscles of all blood vessels, except blood vessels of the brain in which it causes constriction. Caffeine, as well as other methylxanthines, reduces blood viscosity, and may, under certain conditions, remedy the state of the circulatory system. High doses of caffeine cause distinct sinus tachycardia with occasional appearance of extrasystoles. Moderate and therapeutic doses of caffeine do not cause these rhythm disorders. Caffeine increases the working capacity of skeletal muscles.

INDICATIONS: The application of COFFEINUM CUM NATRII BENZOATE is indicated in the following cases: Collapse caused by infectious diseases, fatigue and stress. Depression of respiratory center (breathing) including the one which occurs after the application of the depressor of the central nervous system (CNS) (general anesthetics, barbiturates, and opiate analgetics). Neonatal depression of respiration (asphyxia), exhaustion and weakness during the illness of animals.DOSAGE:Horses, cattle: 2 – 3 ml/100 kg of body massCalves, foals, sheep, pigs, dogs, cats: 0.2 – 0.25 ml/10 kg of body mass.The application is performed where required, and the dose can be repeated during the day (1.5 to 2 hours after the first application).ADMINISTRATION: The medicine is administered by subcutaneous, intramuscular, or intravenous injection. The applica-tion is performed where required, and the dose can be repeated during the day (1.5 to 2 hours after the first application).CONTRAINDICATIONS: Hypertension, arrhythmia, paralysis of peripheral blood vessels, and motor overexcitability. The application of caffeine is contraindicated in racehorses at least 10 days before a race because it is a doping agent.

NOTE: The medicine is not to be used in racehorses at least 10 days before a race. At the point of subcutaneous applica-tion, a transient swelling and pain may occur, so the preliminary dilution of the medicine with water for injections in the ratio 1:4 is recommended. The medicine should not be used in infusions or injections together with chlorpromazine, promazine, promethazine, sympathomimetics, and tetracyclines. Caffeine is a synergist with the preparations of digitalis, β-adrenergic stimulators and calcium preparations, so it should be cautiously applied with these medicines. In horses with a dark hair coat color (bay horse, black horse), the hair coat may sometimes fade at the subcutaneous application point.

ADVERSE REACTIONS: Tremor, vomiting, convulsions, hypotension, extrasystoles, arrhythmia, and polyuria.

Caffeine stimulates the central nervous system (CNS). Higher doses of caffeine cause a stronger central stimulation, manifesting restlessness, tremor and hyperesthesia. Very large doses can cause generalized convulsions. Caffeine stimulates respiratory, vasomotor, and vagal center in the medulla oblongata. Caffeine has a stimulating effect on the cardiovascular system. This effect is primarily manifested as positive inotropic and positive chronotropic effect. Under the influence of caffeine, the heart rate and cardiac output increase. Applied in high enough doses, caffeine causes the relaxation of smooth muscles of all blood vessels, except blood vessels of the brain in which it causes constriction. Caffeine, as well as other methylxanthines, reduces blood viscosity, and may, under certain conditions, remedy the state of the circulatory system. High doses of caffeine cause distinct sinus tachycardia with occasional appearance of extrasystoles. Moderate and therapeutic doses of caffeine do not cause these rhythm disorders. Caffeine increases the working capacity of skeletal muscles.

INDICATIONS: The application of COFFEINUM CUM NATRII BENZOATE is indicated in the following cases: Collapse caused by infectious diseases, fatigue and stress. Depression of respiratory center (breathing) including the one which occurs after the application of the depressor of the central nervous system (CNS) (general anesthetics, barbiturates, and opiate analgetics). Neonatal depression of respiration (asphyxia), exhaustion and weakness during the illness of animals.DOSAGE:Horses, cattle: 2 – 3 ml/100 kg of body massCalves, foals, sheep, pigs, dogs, cats: 0.2 – 0.25 ml/10 kg of body mass.The application is performed where required, and the dose can be repeated during the day (1.5 to 2 hours after the first application).ADMINISTRATION: The medicine is administered by subcutaneous, intramuscular, or intravenous injection. The applica-tion is performed where required, and the dose can be repeated during the day (1.5 to 2 hours after the first application).CONTRAINDICATIONS: Hypertension, arrhythmia, paralysis of peripheral blood vessels, and motor overexcitability. The application of caffeine is contraindicated in racehorses at least 10 days before a race because it is a doping agent.

NOTE: The medicine is not to be used in racehorses at least 10 days before a race. At the point of subcutaneous applica-tion, a transient swelling and pain may occur, so the preliminary dilution of the medicine with water for injections in the ratio 1:4 is recommended. The medicine should not be used in infusions or injections together with chlorpromazine, promazine, promethazine, sympathomimetics, and tetracyclines. Caffeine is a synergist with the preparations of digitalis, β-adrenergicstimulators and calcium preparations, so it should be cautiously applied with these medicines. In horses with a dark hair coat color (bay horse, black horse), the hair coat may sometimes fade at the subcutaneous application point.

ADVERSE REACTIONS: Tremor, vomiting, convulsions, hypotension, extrasystoles, arrhythmia, and polyuria.

44VADEMECUM

ANALEPTICSCOFFEINUM CUM NATRII BENZOATE

ATCVet: QN06BC01COMPOSITION: 1 ml of solution for injection contains:Caffeine 250 mg

WITHDRAWAL PERIOD: No limitations.STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.EXPIRY DATE: 3 years. Use immediately after the first opening.Do not use the medicine after the date indicated on the packaging. PACKAGING: Box with 5 10 ml vials. 50 ml glass vial in a cardboard box.

Solution for injectionfor animal use Analgoantipyretic

EFFECTS: At least five factors have a significant role in the caffeine effect mechanism: Caffeine inhibits phosphodiesterase, thereby increasing the concen-tration of cyclic adenosine monophosphate (cAMP) in the target organs. Caffeine has a direct effect on the concentration of calcium in the cell. It causes hyperpolar-ization of the cell membrane and thus indirectly affects the effects of intracellular calcium. Separation of calcium increase in the cell from contractile elements in muscles blocks adenosine receptors. Like other methylxanthine derivatives (theophylline, theobromine), caffeine loosens smooth musculature (especially bronchioles), stimulates the central nervous system, stimulates the heart muscle, and affects the kidneys by increasing the amount of urine output.

TARGET SPECIES: Horses, foals, cattle, calves, sheep, pigs, dogs, and cats.

WITHDRAWAL PERIOD: No limitations. In cases of emergency slaughter, the tissue from the injection point is to be rejected.

STORAGE CONDITIONS: Keep in original packaging at temperatures up to +25°C. Keep away from children.

DOSAGE: PARAFER is applied one time only in a dose of 2 ml per animal (equivalent to 200 mg of Fe-dextran).

is a colloid, aqueous solution of iron dextran intended for routine prevention of microcytic hypochromic anemia in piglets. Iron dextran provides efficient and significant increase in the hemoglobin level. Also, injectable preparations of iron dextran have a positive effect on the synthesis and red blood cell count. Apart from preventing sideropenic anemia from occurring, iron dextran has a positive effect on growth improvement, as well as increase in vitality and resistance of young piglets.

WITHDRAWAL PERIOD: No limitations. In cases of emergency slaughter, the tissue from the injection point is to be rejected.

STORAGE CONDITIONS: Keep in original packaging at temperatures up to +25°C. Keep away from children.

DOSAGE: PARAFER is applied one time only in a dose of 2 ml per animal (equivalent to 200 mg of Fe-dextran).

is a colloid, aqueous solution of iron dextran intended for routine prevention of microcytic hypochromic anemia in piglets. Iron dextran provides efficient and significant increase in the hemoglobin level. Also, injectable preparations of iron dextran have a positive effect on the synthesis and red blood cell count. Apart from preventing sideropenic anemia from occurring, iron dextran has a positive effect on growth improvement, as well as increase in vitality and resistance of young piglets.

45VADEMECUM

ATCVet: QB03AC90

COMPOSITION: 1 ml of injection solution contains:Trivalent iron (Fe3) 100 mg (in the form of a complex with dextran)

®

TARGET SPECIES: Piglets.®

®

®

EXPIRY DATE: 2 years. Expiry date after opening: use immediately.

PACKAGING: 50 ml glass vial in a cardboard box. 100 ml glass vial in a cardboard box.

ANTIANEMICSPARAFER®

Solution for injectionfor animal use Antianemics

EFFECTS: Iron is vital for the organism of animals and humans. It is an integral part of myoglobin and hemoglobin, necessary for the transport and use of oxygen. Iron is also a componentof important enzymes in the organism. PARAFER , solution for injection

INDICATIONS: PARAFER is intended for prevention and treatment of microcytic hypochromic (sideropenic) anemia in piglets.

CONTRAINDICATIONS: The medicine is not to be used in piglets from sows deficient in vitamin E and/or selenium due to possible sudden deaths (anaphylactic reaction).ADVERSE REACTIONS: Sometimes, in treated animals, particularly in overdoses, local inflammation with limfadenitis, hemolysis and walk disorder may appear, and appearance of an anaphylactic reaction is also not excluded, which occurs within minutes after application or in 3 to 12 hours. Transient change in tissue color may occur at the point of medicine application.NOTE: To avoid sudden death of piglets, it is recommended to initially treat 1 or 2 piglets from a litter, and after a short while the rest of the breeding stock. Not to be used in animals with known hypersensitivity to iron dextran. In case of allergic reactions, adrenalin, and if necessary, antihistamines and glucocorticoids should be immediately administered. The application of the medicine in fatlings is not recommended, but if necessary, the puncture point should be on the neck muscles just behind the ear. When applying the medicine, use sterile needle and syringe. It is not allowed to mix Parafer with other preparations in the same syringe.

ADMINISTRATION: The medicine is administered deep intramuscularly (i.m.) on the inside of the thigh, to piglets aged 2 – 3 days.

DOSAGE: The preparation is administered intramuscularly or perorally to poultry, mixed with drinking water. Animal species (mammals) Medicine quantity in ml/kg of body masscattle, horses 3 – 5 ml/100 kg of body masscalves, foals, sheep, goats, pigs 5 ml/50 kg of body masspiglets, lambs, kid goats 3 ml/25 kg of body massdogs, cats 0.5 ml/5 kg of body massAnimal species (poultry) Medicine quantity in drinking waterchickens – 100 animals of body mass ≈ 1 kg 10 ml ducklings, turkey poults – 100 animals of body mass ≈ 1 kg 20 ml egg laying hens – 100 animals 20 – 30 mlducks – 100 animals 30 – 40 mlturkeys – 100 animals 70 – 80 mlRecommended dosage refers to one-time treatment which can be repeated every 2 to 3 months.If vitamins are given as a supportive therapy, it can be repeated in weekly intervals until full recovery

DOSAGE: The preparation is administered intramuscularly or perorally to poultry, mixed with drinking water. Animal species (mammals) Medicine quantity in ml/kg of body masscattle, horses 3 – 5 ml/100 kg of body masscalves, foals, sheep, goats, pigs 5 ml/50 kg of body masspiglets, lambs, kid goats 3 ml/25 kg of body massdogs, cats 0.5 ml/5 kg of body massAnimal species (poultry) Medicine quantity in drinking waterchickens – 100 animals of body mass ≈ 1 kg 10 ml ducklings, turkey poults – 100 animals of body mass ≈ 1 kg 20 ml egg laying hens – 100 animals 20 – 30 mlducks – 100 animals 30 – 40 mlturkeys – 100 animals 70 – 80 mlRecommended dosage refers to one-time treatment which can be repeated every 2 to 3 months.If vitamins are given as a supportive therapy, it can be repeated in weekly intervals until full recovery

46VADEMECUM

VITAMINSVITAMIN AD3E-S

ATCVet: QA11JA**

COMPOSITION: 1 ml of solution for injection contains:Retinol palmitate 50,000 IUCholecalciferol 25,000 IU Tocopherol acetate 20 mg

TARGET SPECIES: Horses, cattle, sheep, goats, pigs, dogs, cats, chickens, ducks, turkeys.

CONTRAINDICATIONS: Not known.

Solution for injectionfor animal use Vitamins

EFFECTS: Vitamin A has a positive effect on proper forming of the skeletal system of young animals, on proper spermatogenesis, gestation, and embryonic development. It is necessary for all types of epithelium (skin and mucous membranes), it is an integral part of vision pigments rhodopsin and iodopsin, and a co-factor in various biochemical reactions. Vitamin D3 regulates the calcium and phosphorus metabolism, and in that way influences proper skeletal and egg shell development. It improves the calcium and phosphorus intestinal resorption, as well as the mobilization of these two ions from the bones in order to preserve the homeostasis of these elements in blood and bodily fluids.It also participates in the magnesium metabolism. Vitamin E is a specific antioxidant which prevents oxidation and prolongs the biological half-life of semi-saturated fatty acids which are important for the stability of cell membranes. It is necessary for normal functioning of the endocrine glands, especially hypophysis, adrenal glands, and gonads. It helps the immunolog-ical mechanisms and strengthens the resistance to bacterial and viral infections.

ADMINISTRATION: The preparation is administered parenterally (intramuscularly) and perorally to poultry, mixed with drinking water. The medicine is to be administered with half of the daily drinking water requirement, and a fresh solution should be prepared immediately before the administration. In case the dose exceeds 10 ml for cattle and horses and 5 ml for pigs, sheep and goats, the medicine must be administered at two points.

ADVERSE REACTIONS: After intramuscular application, a local, transient reaction (swelling, pain) may occur at the puncture point, and in some cases, an anaphylactic reaction is possible. Very rarely, and only after prolonged administration of higher doses, adverse effects may occur, which are primarily the consequence of hypervitaminosis caused by vitamin A and vitamin D (anorexia, nausea, vomiting, enteritis, diarrhea, cachexia, gingival swelling and bleeding, heart arrhythmia, bone fracturing).NOTE: In case of a hypersensitivity reaction, antihistamines and corticosteroids are to be administered. Retinol reduces the anti-inflammatory effect of glucocorticoids. Barbiturates shorten the biological half-life of cholecalciferol. Tocopherol is a distinct synergist with selenium.

INDICATIONS: It is to be used in animals with high production results, animals in gestation, animals in the lactation stage, and young animals in the rapid growth period.It is to be used during stressful states too, and as a supportive therapy with various diseases. It is also indicated in both hypovitaminosis and avitaminosis, degenerative myopathy, liver dystrophy, rachitis, osteomalacia, tetany, keratitis, nyctalo-pia, sterility in females, and during the convalescence phase.

47VADEMECUM

WITHDRAWAL PERIOD: Meat: 28 days.Milk can be used for human consumption without restriction.

STORAGE CONDITIONS: Keep at temperatures up to 25°C in original packaging, protected from light.Keep away from children.


VITAMINSVITAMIN AD3E-SSolution for injectionfor animal use Vitamins

EXPIRY DATE: 1 year, storing at temperatures up to +25°C. Expiry date is 28 days after first opening, at temperatures up to +25°C. Expiry date after diluting in drinking water is 24 hours, at temperatures up to +25°C.Do not use the medicine after the date indicated on the packaging.

ADVERSE REACTIONS: A local, transient irritant reaction accompanied by pain and swelling may occur after intramuscu-lar or subcutaneous application. Rapid intravenous application may cause collapse.

ADMINISTRATION: Intramuscularly (i.m.), subcutaneously (s.c. ), or slowly intravenously (i.v.). In horses and cattle, the medicine is to be administered deep intramuscularly, subcutaneously, or slowly intravenously. When administering intramuscularly and subcutaneously, not more than 10 ml of medicine should be applied at one point. Before application it is necessary to implement aseptic and antiseptic measures, that is, to disinfect the point where the medicine will be applied.

DOSAGE: To be administered once a day in doses of 10 – 20 ml to horses and cattle; 5 – 10 ml to pigs; and 1 – 5 ml to dogs. The treatment lasts for a number of days, depending on the veterinarian’s estimate.

INDICATIONS: Hypovitaminosis and avitaminosis C (scurvy), bleeding diathesis of different etiology, supportive therapy in the treatment of infectious and contagious diseases, convalescence, poisoning (with bacterial toxins, alimentary) , iatrogen-ic poisoning (with arsenic compounds, sulfonamides, barbiturates, etc.), functional sterility caused by avitaminosis C, treatment of stress, primary and secondary anemia

The basic functional property of ascorbic acid is related to its redox potential, which is why it is a necessary co-factor in numerous metabolically important hydroxylation reactions, e.g. biosynthesis of collagen. It also participates in metabolism of carbohydrates (gluconeogene-sis), fat and proteins, tyrosine, microsomal metabolism of medicines, synthesis of epinephrine

ADVERSE REACTIONS: A local, transient irritant reaction accompanied by pain and swelling may occur after intramuscu-lar or subcutaneous application. Rapid intravenous application may cause collapse.

ADMINISTRATION: Intramuscularly (i.m.), subcutaneously (s.c. ), or slowly intravenously (i.v.). In horses and cattle, the medicine is to be administered deep intramuscularly, subcutaneously, or slowly intravenously. When administering intramuscularly and subcutaneously, not more than 10 ml of medicine should be applied at one point. Before application it is necessary to implement aseptic and antiseptic measures, that is, to disinfect the point where the medicine will be applied.

DOSAGE: To be administered once a day in doses of 10 – 20 ml to horses and cattle; 5 – 10 ml to pigs; and 1 – 5 ml to dogs. The treatment lasts for a number of days, depending on the veterinarian’s estimate.

INDICATIONS: Hypovitaminosis and avitaminosis C (scurvy), bleeding diathesis of different etiology, supportive therapy in the treatment of infectious and contagious diseases, convalescence, poisoning (with bacterial toxins, alimentary) , iatrogen-ic poisoning (with arsenic compounds, sulfonamides, barbiturates, etc.), functional sterility caused by avitaminosis C, treatment of stress, primary and secondary anemia

The basic functional property of ascorbic acid is related to its redox potential, which is why it is a necessary co-factor in numerous metabolically important hydroxylation reactions, e.g. biosynthesis of collagen. It also participates in metabolism of carbohydrates (gluconeogene-sis), fat and proteins, tyrosine, microsomal metabolism of medicines, synthesis of epinephrine

48VADEMECUM

VITAMINSVITAMIN CSolution for injectionfor animal use Vitamins

ATCVet: QA11GA01

COMPOSITION: 1 ml of solution for injection contains:Ascorbic acid 100 mg

TARGET SPECIES: Horses, cattle, pigs, dogs.

CONTRAINDICATIONS: Hypersensitivity to some of the medicine ingredients, as well as acidosis.



EXPIRY DATE: 2 years. Expiry date is 28 days after opening, at temperatures up to +25°C. Do not use the medicine after the date indicated on the packaging.


and anti-inflammatory steroids, metabolism of folic acid, and functions of leukocytes. Ascorbic acid maintains the normal state of intercellular substance, allows normal healing of wounds, detoxification of the body, stimulates defensive functions of the organism, formation of the bone matrix, elasticity of the capillary walls, and stress regulation (corticosterone synthesis).

DOSAGE: It is administered to horses and cattle in doses of 3 to 5 ml per 100 kg of body mass; to calves, foals, sheep,goats, and pigs in doses of 5 ml per 50 kg of body mass; to piglets, lambs, and kid goats in doses of 3 ml of medicine per 25 kg of body mass; to newborn lambs and kid goats in doses of 1 to 2 ml; to dogs, cats, and rabbits in doses of 0.5 ml per 5 kg of body mass. Chickens (100 animals of body mass about 1 kg) are administered 10 ml of medicine in drinking water; ducklings, turkey poults, goslings (100 animals of body mass about 1 kg) are administered 20 ml of medicine; laying hens (100 animals) are administered 20 to 30 ml of medicine; ducks (100 animals) are administered 30 to 40 ml of medicine; geese (100 animals) are administered 50 ml of medicine; and turkeys (100 animals) are administered 70 to 80 ml of medicine. For treatment purposes, the medicine can be administered in intervals of one week, and for prophylactic purposes once in two months.

DOSAGE: It is administered to horses and cattle in doses of 3 to 5 ml per 100 kg of body mass; to calves, foals, sheep,goats, and pigs in doses of 5 ml per 50 kg of body mass; to piglets, lambs, and kid goats in doses of 3 ml of medicine per 25 kg of body mass; to newborn lambs and kid goats in doses of 1 to 2 ml; to dogs, cats, and rabbits in doses of 0.5 ml per 5 kg of body mass. Chickens (100 animals of body mass about 1 kg) are administered 10 ml of medicine in drinking water; ducklings, turkey poults, goslings (100 animals of body mass about 1 kg) are administered 20 ml of medicine; laying hens (100 animals) are administered 20 to 30 ml of medicine; ducks (100 animals) are administered 30 to 40 ml of medicine; geese (100 animals) are administered 50 ml of medicine; and turkeys (100 animals) are administered 70 to 80 ml of medicine. For treatment purposes, the medicine can be administered in intervals of one week, and for prophylactic purposes once in two months.

49VADEMECUM

VITAMINS WITH MINERALSPROMTSELEN®

ATCVet: QA11AA04COMPOSITION: 1 ml of solution for injection contains: Vitamin A-palmitate 50,000 IUCholecalciferol 25,000 IU RRR-alpha-tocopheryl acetate 20 mgSodium selenite, pentahydrate 0.5 mg

TARGET SPECIES: Horses, cattle, sheep, goats, pigs, dogs, cats, chickens, ducks, geese, and turkeys.

WITHDRAWAL PERIOD: Meat: 28 days. The milk of treated animals can be used for human consumptionwithout restriction. STORAGE CONDITIONS: Keep away from children. Keep at temperatures up to +25°C, protected from light andmoisture.EXPIRY DATE: Expiry date: 1 year. The medicine is to be used immediately after the first opening.Do not use the medicine after the date indicated on the packaging.PACKAGING: 100 ml glass vial in a cardboard box.

Solution for injectionfor animal use Vitamins with minerals

absorption from the digestive tract, increases their concentration in the blood, mobilizes calcium from bones, and provides the return resorption of calcium from kidneys. Tocopheryl acetate exhibits antioxidant effect in the organism and prevents autoxidation of unsaturated fatty acids thereby removing the possibility of formation of toxic peroxides. In this way it protects the stability of carotene and retinol, protects the integrity of the cell, especially its membrane, which is expressed in muscles, bone marrow, nervous system, blood vessels, adipose tissue, and glands with internal secretion. The biological role of selenium is the incorporation into the cysteine, the amino acid from the glutathione peroxidase enzyme, which, with the help of glutathione, reduces the organic hydroperoxides, thereby protecting the cell membrane lipids, proteins and nucleic acids from oxidation. Selenium is a component of heme oxygenase. The oxidative effect of selenium is therefore identical to the effect of tocopherol acetate, but it is much more effective in the presence of this vitamin.

INDICATIONS: Prevention and treatment of hypovitaminosis and avitaminosis, lack of selenium, breeding diseases in young animals (rickets, degenerative myopathy, muscular dystrophy, osteomalacia, keratitis, bleeding diathesis, encephalo-malacia, growth retardation), disorders in reproduction (reduced fertility, sterility), and to increase immunity against infectious diseases and stress.

ADMINISTRATION: By subcutaneous or intramuscular injection, and in poultry in drinking water, twice with a 14-day interval. When administered in the prescribed doses, the medicine meets the needs of vitamins and selenium during 2 – 3 months. The medicine is not to be administered intravenously. Application at multiple points is recommended when administering high doses of this preparation. Therefore, the quantity of medicine greater than 10 ml for large animals (horses, cattle) and 5 ml for small ones should be divided and applied at two injection points.CONTRAINDICATIONS: The preparation can be used in cows and sheep during lactation because according to the most recent resources a withholding period is not needed for milk. The preparation is not to be used in animals hypersensitive to components from the preparation, especially in cattle. The medicine is also not to be used in egg laying hens.ADVERSE REACTIONS: Local irritation (swelling) sometimes occurs at the injection point (subcutaneous and intramus-cular application), which spontaneously disappears after a few days.NOTE: Before application it is necessary to implement aseptic and antiseptic measures and disinfect the skin at the medicine injection point. The vial should be shaken before use

EFFECTS: Retinol is a regulator of metabolic processes of protein conversion, especially in epithelial cells, where it manages the synthesis of mucoproteins and glycoproteins, which is especially reflected in the epithelium of the conjunctiva, eye, lacrimal glands, respiratory, digestive and urogenital organs, which has a positive effect on the epithelial defense mechanisms during infections. Retinol participates in the synthesis of thyroid hormones, adrenal gland and sex hormones, thus promoting growth, and together with opsin protein makes rhodopsin, the visual purple. Cholecalciferol plays an important role in the regulation of transport of calcium and phosphor to the organism and promotes their

NOTE: In order to achieve a more complete treatment effect with the proposed Ketal preparation, intravenous applicationof glucose is also recommended. Handle this medicine cautiously in order to avoid accidental contact with skin or eyes. In case of contact of the medicine with skin or eyes, rinse with plenty of water.

Copper sulfate pentahydrate (CuSO4 •5H2O) – Copper is an essential component in animal systems. It is necessary for hemoglobin production in mammals and birds. Copper is an integral part of numerous enzymes involved in oxidative processes such as tyrosinase, dopamine hydroxylase, monoamine oxidase, lactase, ascorbic acid oxidase, phenol oxidase, uricase, and cytochrome oxidase.Cobalt sulfate heptahydrate (CoSO4) Addition of cobalt into the selected KETAL formulation enables accelerated synthesis of vitamin B12 which, as “protectivum hepatis”, acts by stimulating regeneration of liver cells, slows down the accumulation of fatty substances and performs detoxification of harmful substances.Manganese sulfate monohydrate (MnSO4 H2O) – Manganese is very important for growth, skeletal development, and reproduction. It is primarily involved in the metabolism of carbohydrates and lipids, and the utilization of glucose.

NOTE: In order to achieve a more complete treatment effect with the proposed Ketal preparation, intravenous applicationof glucose is also recommended. Handle this medicine cautiously in order to avoid accidental contact with skin or eyes. In case of contact of the medicine with skin or eyes, rinse with plenty of water.

Copper sulfate pentahydrate (CuSO4 •5H2O) – Copper is an essential component in animal systems. It is necessary for hemoglobin production in mammals and birds. Copper is an integral part of numerous enzymes involved in oxidative processes such as tyrosinase, dopamine hydroxylase, monoamine oxidase, lactase, ascorbic acid oxidase, phenol oxidase, uricase, and cytochrome oxidase.Cobalt sulfate heptahydrate (CoSO4) Addition of cobalt into the selected KETAL formulation enables accelerated synthesis of vitamin B12 which, as “protectivum hepatis”, acts by stimulating regeneration of liver cells, slows down the accumulation of fatty substances and performs detoxification of harmful substances.Manganese sulfate monohydrate (MnSO4 H2O) – Manganese is very important for growth, skeletal development, and reproduction. It is primarily involved in the metabolism of carbohydrates and lipids, and the utilization of glucose.

50VADEMECUM

Oral solutionfor animal use Anti-ketosis medicine

PREPARATIONS AGAINST KETOSISKETAL

ATCvet: QA16QA** COMPOSITION: 1 ml of oral solution contains:Propylene glycol 830 mgDL-Methionine 18 mgCobalt(II) sulfate, heptahydrate 0.1 mgManganese(II) sulfate, monohydrate 0.2 mgCopper(II) sulfate, pentahydrate 0.15 mg

TARGET SPECIES: Cattle.

ADMINISTRATION: Application by adding into drinking water.CONTRAINDICATIONS: Not known. ADVERSE REACTIONS: Not known.

WITHDRAWAL PERIOD: No limitations. STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Do not keep in a refrigeratorand do not freeze. Keep away from children.EXPIRY DATE: 3 years. Expiry date after first opening: 28 days, at temperatures up to +25°C.Expiry date after diluting in drinking water: 24 hours, at temperatures up to +25°C. Do not use the medicine after the date indicated on the packaging.PACKAGING: 1000 ml plastic bottle.

EFFECTS: The effect of KETAL is based on the glycogenoplastic effect of propylene glycol, which normalizes glycogen reserves in liver and glucose concentration in the body. After the peroral application, propylene glycol is reabsorbed directly from the rumen and reduces ketogen-esis. Conversion of propylene glycol into glucose occurs through conversion to pyruvate, with the consequent production of oxaloacetate via pyruvate carboxylase, that is, in the same way as the metabolism of propionate which is produced in the kidney under the effect of bacterial enzymes from food carbohydrates. Propylene glycol is a substitute for glycogenoplastic substance (propio-nate) which restores a negative energy balance. Other substances in the KETAL formulation complement the effect of energy substituents. Methionine has a function primarily as a methyl donor for biological transmethylation and for the synthesis of organic sulfur compounds. Its effect is manifested especially in cases where the required amounts of methionine are not ingested into the organism with feed. Methionine is a precursor to other amino acids which contain sulfur (cystin) and some hormones,especially insulin. It helps the synthesis of hemoglobin, regulates the functioning of thyroid gland and accelerates the healing of wounds.

INDICATIONS: Treatment of subclinical and clinical ketosis. Improvement of general condition immediately before parturition, as well as in the period after calving in highly productive dairy cows.DOSAGE: The daily dose is 300 – 500 ml per animal. The daily dose can be mixed with the total daily amount of water and put at the disposal of animals to drink at will, or divided and given to animals twice (during the morning and evening feeding). The treatment is repeated twice during 4 to 5 days.

EFFECTS: Glucose is physiological sugar and serves as an energy source in the organism. It has a positive effect on physiological functions of all organs, especially the central nervous system (CNS), vegetative nervous system, heart, and other organs with high activity. Glucose is used as a source of carbohydrates in parenteral nutrition and in the treatment of various metabolic disorders accompanied by hypoglycemia.Hypertonic glucose solutions allow the withdrawal of fluid from the tissue (transudates, exudates) thereby eliminating edema, and may therefore have anti-inflammatory effect. Glucose reduces the catabolism of fat and protein and nitrogen loss, thus preventing the formation of acidosis and ketosis. Intravenous infusion of glucose eliminates hypoglycemia and edema. An increase of glycogen in the liver does not occur after an intravenous injection of glucose. It has a positive effect in poisoning caused by various compounds, ensuring greater supply of cells with energy.

EFFECTS: Glucose is physiological sugar and serves as an energy source in the organism. It has a positive effect on physiological functions of all organs, especially the central nervous system (CNS), vegetative nervous system, heart, and other organs with high activity. Glucose is used as a source of carbohydrates in parenteral nutrition and in the treatment of various metabolic disorders accompanied by hypoglycemia.Hypertonic glucose solutions allow the withdrawal of fluid from the tissue (transudates, exudates) thereby eliminating edema, and may therefore have anti-inflammatory effect. Glucose reduces the catabolism of fat and protein and nitrogen loss, thus preventing the formation of acidosis and ketosis. Intravenous infusion of glucose eliminates hypoglycemia and edema. An increase of glycogen in the liver does not occur after an intravenous injection of glucose. It has a positive effect in poisoning caused by various compounds, ensuring greater supply of cells with energy.

51VADEMECUM

Solution for infusionfor animal use Nutritives

NUTRITIVESGLUCOSUM

ATCvet: QB05BA03 COMPOSITION: 1 ml of solution for infusion contains:Glucose monohydrate 500 mg

TARGET SPECIES: Horses, cattle, pigs, sheep, dogs, cats.

DOSAGE:The medicine is to be applied in the following doses:

ADMINISTRATION: Hypertonic glucose solutions: intravenous use only. Isotonic 5% glucose solutions: intravenous and subcutaneous use.

WITHDRAWAL PERIOD: Zero (0) days. STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.EXPIRY DATE: 3 years. Expiry date after opening: use immediately. Do not use the medicine after the dateindicated on the packaging.PACKAGING: 100 ml glass vial in a cardboard box. 500 ml plastic bottle.

Glucose 50% solution 5% solutioncattle and horses: 100-250 ml 500-2000 ml pigs: 30-100 ml 50-400 mlsheep: 50-100 ml 50-400 mldogs and cats: 10-50 ml 50-400 ml

INDICATIONS: The treatment of primary and secondary hypoglycaemia and parenteral feeding regimen in cattle, horses, pigs, sheep, dogs, and cats; treatment of ketosis (acetonaemia) in cattle; as adjunctive therapy for pregnancy toxemia in sheep. It can be used for temporary relief of cerebral edema and hypoglycemic coma symptoms, and as supportive therapy for poisoning, inflammatory and edematous processes.

CONTRAINDICATIONS: Hyperglycemia, diabetic coma, chronic nephritis, intracranial and intraspinal bleeding. Hypertonic glucose solution is not to be administered subcutaneously because it causes local irritation (swelling and pain).ADVERSE REACTIONS: Intravenous application of glucose solutions, especially of hyperosmolar solutions which have a low pH, may cause local reaction in the form of pain, irritation of veins and thrombophlebitis, as well as necrosis of the tissue in case of extravasation. Application of glucose solution may cause fluid and electrolyte imbalance, hyperglycemia, hypoka-lemia, hypophosphatemia, and hypomagnesaemia. The result of a rapid intravenous infusion of the preparation and/or preparation overdose may be hyperglycemia with consequent glycosuria, osmotic diuresis and dehydration.NOTE: 5% solution is prepared by adding one part of 50% glucose into nine parts of water for injection, that is, Ringer's or saline solution. Before the administration, the preparation temperature must be matched to the animal’s body temperature. If necessary, the treatment can be repeated, but if possible another vein should be used. Glucosum 50% as a hyperosmolar solution may be administered only by slow intravenous infusion dropwise (not more than 3 ml/min). Rapid intravenous application of glucose solution may lead to the development of hyperglycemia, glycosuria and osmotic diuresis. 5% glucose solution should not be applied faster than 10 ml/kg/h. If a greater quantity of the solution is to be administered subcutane-ously, the total quantity should be applied at more points.

ADVERSE REACTIONS: Intensive local reaction at the point of medicine administration after subcutaneous administration of calcium salts. Rapid administration of the medicine causes increased sweating and hyperemia. Rapid intravenous administration can lead to ventricular fibrillation or heart block, which can be neutralized by atropine.NOTE: Due to the possible occurence of local edema (especially in dogs) which spontaneously resolves in a couple of days, it is advisable to apply the subcutaneous injections (especially larger amounts of the medicine) at several points. Also, due to the possible occurrence of ventricular fibrillation or heart block, intravenous injections should be injected slowly. In case of arrhythmias and bradycardia, the administration of the medicine should be suspended and atropine should be adminis-tered. The most significant manifestation is the synergism between calcium ions and digitalis glycosides, so calcium salts should not be given to digitalized patients as they can cause cardiac arrest. Calcium ion changes vasoactive properties of atropine, pilocarpine, and other substances. The preparations intended for intravenous administration are to be tempered just before application.

CONTRAINDICATIONS: The medicine is not used in animals that are simultaneously treated or are under influence of cardiotonic glycosides. Do not use with caffeine, aminophylline, and thiazide diuretics. The preparation is not used in hypovolemic conditions and kidney damages. Not to be administered intramuscularly.

INDICATIONS: Tetany (grass tetany, transport tetany), tetanic convulsions in calves suffering from acute rhinitis, puerperal pathology (paresis, hemoglobinuria, paraplegia), allergic conditions, inflammatory exudative conditions, reduction of blood coagulation ability, bleedings, some intoxications (carbon tetrachloride, oxalic acid, etc.).

ADVERSE REACTIONS: Intensive local reaction at the point of medicine administration after subcutaneous administration of calcium salts. Rapid administration of the medicine causes increased sweating and hyperemia. Rapid intravenous administration can lead to ventricular fibrillation or heart block, which can be neutralized by atropine.NOTE: Due to the possible occurence of local edema (especially in dogs) which spontaneously resolves in a couple of days, it is advisable to apply the subcutaneous injections (especially larger amounts of the medicine) at several points. Also, due to the possible occurrence of ventricular fibrillation or heart block, intravenous injections should be injected slowly. In case of arrhythmias and bradycardia, the administration of the medicine should be suspended and atropine should be adminis-tered. The most significant manifestation is the synergism between calcium ions and digitalis glycosides, so calcium salts should not be given to digitalized patients as they can cause cardiac arrest. Calcium ion changes vasoactive properties of atropine, pilocarpine, and other substances. The preparations intended for intravenous administration are to be tempered just before application.

CONTRAINDICATIONS: The medicine is not used in animals that are simultaneously treated or are under influence of cardiotonic glycosides. Do not use with caffeine, aminophylline, and thiazide diuretics. The preparation is not used in hypovolemic conditions and kidney damages. Not to be administered intramuscularly.

INDICATIONS: Tetany (grass tetany, transport tetany), tetanic convulsions in calves suffering from acute rhinitis, puerperal pathology (paresis, hemoglobinuria, paraplegia), allergic conditions, inflammatory exudative conditions, reduction of blood coagulation ability, bleedings, some intoxications (carbon tetrachloride, oxalic acid, etc.).

52VADEMECUM

ATCVet: QA12AA**

COMPOSITION: 1 ml of solution for injection contains:Calcium borogluconate 200 mg (corresponds to 16.6 mg/ml of calcium)

TARGET SPECIES: Horses, cattle, sheep, goats, pigs, dogs.

DOSAGE: The medicine is administered intravenously or subcutaneously in the following dosesCattle and horses 100 – 250 mlSheep and goats 25 – 50 mlPigs weighing over 100 kg 50 – 100 mlPigs weighing less than 100 kg 10 – 50 mlDogs 5 – 20 mlThe treatment can be repeated up to three times, at intervals of not shorter than 12 to 24 hours.

ADMINISTRATION: parenterally slowly (i.v.) and subcutaneously (s.c.).


STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging. Keep away from children.EXPIRY DATE: 2 years. Expiry date after first opening 28 days, at temperatures up to +25 °C.Do not use the medicine after the date indicated on the packaging.

PACKAGING: 100 ml glass vial in a cardboard box. 500 ml glass vial in a cardboard box.

Solution for injectionfor animal use Electrolyte solution

OTHER HEMOPHARMACEUTICALSCALCIUM BOROGLUCONICUM

EFFECTS: CALCIUM BOROGLUCONICUM contains calcium borogluconate as an active substance, which, as a source of calcium, has a number of important roles in the organism. Calcium is mainly involved in maintaining the stability of hydroxyapa-tite of bones. In addition, calcium has a significant role in muscle contraction, actively affects the central nervous system (CNS), it is involved in maintaining the permeability of the membrane, reduces the permeability of blood vessels, tones the heart muscle, and is essential for the normal heart function, it is necessary for blood coagulation, and activates the reticuloendothelial system and enhances phagocytic activity of leukocytes. Calcium is administered parenterally when it is necessary to remediate urgent hypocalcaemic conditions. Quite often in such cases, intravenous and subcutaneous applications of calcium salts solutions are combined. Calcium borogluconate is administered in case of bleeding in order to improve blood coagulation.Calcium borogluconate can be used in case of circulatory shock. In allergic manifestations (with increased capillary permea-bility), calcium borogluconate may be administered parenterally in usual doses.

VADEMECUM

DIETARYSUPPLEMENTS

54VADEMECUM

(Vitamin supplement for animals)Manufactured according to productionspecification

DIETARY SUPPLEMENTSSUBOVIT-OL® AD3E

COMPOSITION: 1 ml of solution contains:

• Vitamin A 50 000 IU• Vitamin D3 25 000 IU• Vitamin E 20 mg

TARGET SPECIES: Broilers, egg laying hens, turkeys, ducks, pigeons, pigs, cattle, horses, sheep, goats, dogs,and rabbits.

ADMINISTRATION AND DOSAGE:The preparation is administered perorally in drinking water for 3 to 5 days in the following daily amounts:

• For broilers that are up to 4 weeks of age: 5 ml per per 10 L of drinking water• For broilers that are over 4 weeks of age: 3 ml per per 10 L of drinking water• Egg laying hens: 2 ml per per 10 L of drinking water• Turkeys and ducks: 4 ml per per 10 L of drinking water• Pigeons: 2 ml per per 10 L of drinking water• Pigs, cattle, and horses: 20 ml per per 100 L of drinking water• Sheep, goats, and dogs: 2 ml per per 10 L of drinking water• Rabbits: 2 ml per per 10 L of drinking water

(1 ml = 20 drops of the solution)

NOTE: Fresh solution should be made daily.



PACKAGING: 20 ml glass vial in a cardboard box. 1000 ml plastic bottle.

EFFECTS: Vitamin A is needed for normal structure and functioning of epithelial cells, for growth (especially of bones), reproduction and embryonic development, as well as to maintain the stability of cell membrane. It participates in a number of biochemical processes and it is an integral part of visual pigments. Vitamin A increases resistance to many diseases. It prevents occurrence of degenerative and pathological changes in the nervous system, eyes, and reproductive organs.Vitamin D3 regulates the calcium and phosphorus metabolism, and thus influences proper skeletal, dental and egg shell development. It prevents the occurrence of tetany, rickets, osteomalacia, bone, and joint deformities. It is also involved in magnesium metabolism.Vitamin E prevents oxidation and extends the biological half-life of polyunsaturated fatty acids, speeds up resorption and improves the utilization of retinol, stabilizes the cell membranes and thus influences the metabolism of protein, carbohydrates, fats, minerals and water. Apart from that, it is necessary for normal functioning of the endocrine glands, especially hypophysis, adrenal glands, and gonads.It has a positive effect on the development of the fetus. It helps the immunological mechanisms and strengthens the resistance to bacterial and viral infections. It prevents muscular dystrophy.The needs for these vitamins are especially present in animals with high production results, in young animals, in gestation and lactation, during various illnesses, as well as during convalescence and stressful states. The preparation intended for increase of immunity, better feed utilization, faster gain in weight, reduction of losses in chickens, better egg laying capacity and reduction of stress in poultry due to vaccination, change of facility, transport, and bad weather conditions.

EFFECTS: NEOSANINGEST preparation is used as a dietary supplement for ruminants and its ingredients support the development of bacterial flora in the rumen of ruminants, helps regulate the pH value of the recticulorumen contents, and participates in the metabolism of microorganisms through trace elements, all of which enables better digestion in the recticulorumen of ruminants.

EFFECTS: NEOSANINGEST preparation is used as a dietary supplement for ruminants and its ingredients support the development of bacterial flora in the rumen of ruminants, helps regulate the pH value of the recticulorumen contents, and participates in the metabolism of microorganisms through trace elements, all of which enables better digestion in the recticulorumen of ruminants.

55VADEMECUM

(Dietary supplement for ruminants)Manufactured according to productionspecification

DIETARY SUPPLEMENTSNEOSANINGEST®

COMPOSITION: 1 g of powder contains:

• Calcium carbonate 240 mg• Calcium oxide 20 mg• Cobalt sulfate 20 μg• Copper sulfate 500 μg• Zinc sulfate 50 μg• Manganese sulfate 500 μg• Iron sulfate 500 μg• Gentian root (powdered) 20 mg• Medium up to 1 g

®

TARGET SPECIES: Cattle, sheep, goats.

• Cattle: 200 - 500 g (depending on case severity)• Calves: 100 - 250 g• Sheep and goats: 125 g

STORAGE CONDITIONS: Keep at temperatures up to +25oC in original packaging. Keep away from children.



ADMINISTRATION AND DOSAGE: Perorally (p.o.) in drinking water.The preparation is applied by pouring the contents of one bag into 1 to 2 liters of water, stirring it thoroughly, and adminis-tering it to the animal using a bottle or a probe. Use of a probe is recommended when administering the preparation to sheep.The preparation is administered perorally in the following daily amounts:

EFFECTS: Vitamins are necessary for growth and regulation of metabolism in the body. They stimulate general resistance to infectious, parasitic and breeding diseases, as well as to stressful situations.They also have a certain value as supportive therapy and with reconvalescents. The composition of ŽIVIMICIN Fattening Powder includes microelements (copper, iron, zinc, and manganese) which take part in microorganism metabolism as biocatalysts and thus help develop the microflora needed for proper digestion. The preparation is intended for increase of immunity, better feed utilization, faster gain in weight, reduction of losses in chickens and reduction of stress in poultry due to vaccination, change of facility, transport, and bad weather conditions. It is also used in cases of hypovitaminosis and avitaminosis, and as supportive therapy in case of diseases of different etiology, for the purpose of increasing vitality and resistance.

ADMINISTRATION AND DOSAGE: The preparation is administered p.o. in drinking water or mixed with feed.The recommended dosage applies to a single treatment. If vitamins are given as supportive therapy, administration in the specified doses can be repeated in weekly intervals.The dose for 100 chickens is 10 to 20 g of the preparation mixed with feed or drinking water; for 100 goslings or turkey poults the dose is 50 g of the preparation mixed with feed or drinking water.

EFFECTS:EFFECTS: Vitamins are necessary for growth and regulation of metabolism in the body. They stimulate general Vitamins are necessary for growth and regulation of metabolism in the body. They stimulate general resistance to infectious, parasitic and breeding diseases, as well as to stressful situations.They also have a certain resistance to infectious, parasitic and breeding diseases, as well as to stressful situations.They also have a certain value as supportive therapy and with reconvalescents. The composition of value as supportive therapy and with reconvalescents. The composition of ŽIVIMICINŽIVIMICIN Fattening PowderFattening Powder includes includes microelements (copper, iron, zinc, and manganese) which take part in microorganism metabolism as biocatalysts and microelements (copper, iron, zinc, and manganese) which take part in microorganism metabolism as biocatalysts and thus help develop the microflora needed for proper digestion. The preparation is intended for increase of immunity, thus help develop the microflora needed for proper digestion. The preparation is intended for increase of immunity, better feed utilization, faster gain in weight, reduction of losses in chickens and reduction of stress in poultry due to better feed utilization, faster gain in weight, reduction of losses in chickens and reduction of stress in poultry due to vaccination, change of facility, transport, and bad weather conditions. It is also used in cases of hypovitaminosis and vaccination, change of facility, transport, and bad weather conditions. It is also used in cases of hypovitaminosis and avitaminosis, and as supportive therapy in case of diseases of different etiology, for the purpose of increasing vitality avitaminosis, and as supportive therapy in case of diseases of different etiology, for the purpose of increasing vitality and resistance.and resistance.

ADMINISTRATION AND DOSAGE: AND DOSAGE: The preparation is administered p.o. in drinking water or mixed with feed. The preparation is administered p.o. in drinking water or mixed with feed.The recommended dosage applies to a single treatment. If vitamins are given as supportive therapy, administration in The recommended dosage applies to a single treatment. If vitamins are given as supportive therapy, administration in the specified doses can be repeated in weekly intervals.the specified doses can be repeated in weekly intervals.The dose for 100 chickens is 10 to 20 g of the preparation mixed with feed or drinking water; for 100 goslings or turkey The dose for 100 chickens is 10 to 20 g of the preparation mixed with feed or drinking water; for 100 goslings or turkey poults the dose is 50 g of the preparation mixed with feed or drinking water.poults the dose is 50 g of the preparation mixed with feed or drinking water.

56VADEMECUM

Vitamin-mineral feed supplement for broilers)Manufactured according to production specification

DIETARY SUPPLEMENTSŽIVIMICINFATTENING POWDER

®


• Retinol palmitate (vit. A) 3000 IU• Cholecalciferol (vit. D3) 300 IU• Tocopherol (vit. E) • Riboflavin (vit. B2

1 mg (1 IU) 3 mg

• Cyanocobalamin (vit. B12) 2 μg• Menadione (vit. K3) 1 mg• Nicotinamide (vit. B3) 13 mg• Pyridoxine Hydrochloride (vit. B6) 1 mg• Pantothenic acid 5 mg• Ascorbic acid (vit. C) 50 mg• Copper sulfate pentahydrate 500 μg• Iron sulfate heptahydrate 500 μg• Zinc sulfate heptahydrate 50 μg• Manganese sulfate monohydrate 500 μg• Medium up ot 1 g

®

TARGET SPECIES: Broiler chickens



PACKAGING: Bags containing 20 g of powder.

ADMINISTRATION AND DOSAGE:For chickens: Dissolve 5 g of Amivit in 1 l of drinking water and administer during the first 7 days of life; later on if necessary or periodically 20 g of Amivit per 4 l of drinking water in intervals of 3 to 5 days.For adult animals and egg laying hens: Dissolve 5 g of Amivit in 2 l of drinking water or dissolve 20 g in 8 l of water.Administer periodically from 5 to 10 days.

EFFECTS: Metabolic changes such as reduced feed intake, weight loss or decline in egg yield occur due to lack of vitamins and amino acids in the body. Amivit is a preparation intended for increase of immunity, better feed utilization, faster gain in weight, reduction of losses in chickens, better egg yield and reduction of stress in poultry due to vaccination, transport, bad weather conditions.

ADMINISTRATION AND DOSAGE:For chickens: Dissolve 5 g of Amivit in 1 l of drinking water and administer during the first 7 days of life; later on if necessary or periodically 20 g of Amivit per 4 l of drinking water in intervals of 3 to 5 days.For adult animals and egg laying hens: Dissolve 5 g of Amivit in 2 l of drinking water or dissolve 20 g in 8 l of water.Administer periodically from 5 to 10 days.

EFFECTS: Metabolic changes such as reduced feed intake, weight loss or decline in egg yield occur due to lack of vitamins and amino acids in the body. Amivit is a preparation intended for increase of immunity, better feed utilization, faster gain in weight, reduction of losses in chickens, better egg yield and reduction of stress in poultry due to vaccination, transport, bad weather conditions.

57VADEMECUM


Vitamin A 600 IUVitamin D3 400 IUVitamin E 400 µgVitamin B1 720 µgVitamin B2 1.40 mgVitamin B3 (Nicotinamide) 14 mgVitamin B5 4 mgVitamin B6 1.40 mgVitamin B12 0.4 µgVitamin K3 200 µgFolic acid 22 µgVitamin H (Biotin) 60 µgAscorbic acid (Vitamin C) 300 µgL-Treonin 150 mgL-Tryptophan 32 mgDL-Methionine 100 mgL-Lysine 170 mg

TARGET SPECIES: Broiler chickens, egg laying hens.

STORAGE CONDITIONS: Keep at temperatures up to +25°C in original packaging.


PACKAGING: 20 g bag, 100 g bag, 1 kg bag.

(Amino acid - vitamin preparation for poultry)Manufactured according toproduction specification

DIETARY SUPPLEMENTSAMIVIT

58VADEMECUM

(Vitamin feed supplement for animals)Manufactured according to productionspecification

DIETARY SUPPLEMENTSVITAMIN C

COMPOSITION: 1 g of powder contains: Vitamin C 100 mg

TARGET SPECIES: Horses, cattle, pigs, poultry, pigeons, and rabbits.

STORAGE CONDITIONS: Keep at temperatures up to +25°C, protected from moisture and light.Keep away from children.


PACKAGING: 20 g bag, 1 kg bag, and 25 kg bag.

EFFECTS: Vitamin C is the strongest antioxidant among vitamins. It has an important role in creation of intracellular substance in the animal organism, serves as a stabilizer of adrenal hormones, participates in carbohydrates metabolism, has an impact on nitrogen metabolism, especially creatinine, stimulates creation of antibodies, reduces blood coagulation, inactivates certain toxins and reduces the toxicity of certain medicines in the body. Lack of this vitamin is manifested in the form of gingivitis, stomatitis, loosening of teeth, hemorrhages in the skin, mucous membranes, internal organs, muscles, muscle weakness, fatigue, tendency to infections, poor wound healing, sterility, etc.It is recommended in case of stress, major physical effort, infectious diseases, gestation, lactation, and other physical conditions that increase the need for this vitamin.

ADMINISTRATION AND DOSAGE:Vitamin C is administered perorally after being dissolved in drinking water,during 3 to 5 days.Pigs: 5 g dissolved in 10 liters of drinking waterPoultry and turkeys: 10 – 20 g dissolved in 10 liters of drinking water Egg laying hens: 20 – 30 g dissolved in 10 liters of drinking water Pigeons and rabbits: 10 – 20 g dissolved in 10 liters of drinking water Horses and cattle: 10 – 20 g per animal

ADMINISTRATION AND DOSAGE:Horses: 1 g per kg of body weight dissolved in 4 liters of lukewarm water (administered through a nasal probe).Cattle: 250 – 500 g dissolved in 5 – 8 liters of lukewarm water, administered perorally through a feeding bottle.Sheep and goats: 2 – 5 tablespoons dissolved in ¼ liters of water, administered through a feeding bottle.Pigs: 25 – 125 g mixed with feed.Dogs: 5 – 25 g of dissolved medicine administered perorally.Cats: 2 – 5 g of dissolved preparation administered perorally.

EFFECTS: Magnesium sulfate administered perorally as a concentrated solution acts as an osmotic laxative by changing the osmotic pressure in the digestive tract. Neither magnesium nor the sulphate ion are resorbed from the digestive tract, but they osmotically retain a big quantity of water in the intestines, which results in increase of volume of intestinal contents, a reflex increase of intestinal peristalsis and thus to bowel movements.

ADMINISTRATION AND DOSAGE:Horses: 1 g per kg of body weight dissolved in 4 liters of lukewarm water (administered through a nasal probe).Cattle: 250 – 500 g dissolved in 5 – 8 liters of lukewarm water, administered perorally through a feeding bottle.Sheep and goats: 2 – 5 tablespoons dissolved in ¼ liters of water, administered through a feeding bottle.Pigs: 25 – 125 g mixed with feed.Dogs: 5 – 25 g of dissolved medicine administered perorally.Cats: 2 – 5 g of dissolved preparation administered perorally.

EFFECTS: Magnesium sulfate administered perorally as a concentrated solution acts as an osmotic laxative by changing the osmotic pressure in the digestive tract. Neither magnesium nor the sulphate ion are resorbed from the digestive tract, but they osmotically retain a big quantity of water in the intestines, which results in increase of volume of intestinal contents, a reflex increase of intestinal peristalsis and thus to bowel movements.

59VADEMECUM

(Dietary supplement for animals)Manufactured according toproduction specification

DIETARY SUPPLEMENTSLAKSANTIV

COMPOSITION: 1g of powder contains Mg SO4 x 7 H2OMagnesium sulfate heptahydrate) 1000 mg

TARGET SPECIES: Horses, cattle, sheep, goats, pigs, dogs, and cats.

NOTE: Do not give to dehydrated animals or in case of renal dysfunction.


EXPIRY DATE: 2 years. To be used immediately after opening.


VADEMECUM

DERMOCOSMETIC PRODUCTS

Vitamin E acetate (Tocopherolis acetas) is the best known antioxidant that protects cell membranes from the damaging effects of freeradicals, increases moisture of the surface layer of the skin and its capacity to bind water.Lavender essential oil (Lavandulae aetheroleum) contains linalyl acetate, linalool, tannins, flavonoids, and phytosterols. It has an antiseptic and anti-inflammatory effect in skin diseases and inflammations. It speeds up healing of wounds and burns.Boric acid (Acidum boricum) is an efficient antiseptic which prevents secondary bacterial infection. It has an anti-inflamma-tory effect – decreases inflammation, soothes the skin, and relieves itching.

NOTE: Keep away from children!After direct contact of the ointment with the hands, wash the hands thoroughly.Avoid contact with eyes. If the ointment comes into contact with eyes, wash your eyes with lukewarm water and lukewarm camomile tea.

When to apply FLOGO ointment?Because of its composition and action, FLOGO ointment is fast and efficient in relieving all inflammatory skin and cutaneous mucous membrane conditions – therefore, our product is one of the top products for external use.It is used for reducing inflammation of eczematous skin, boils, acne and spots, ingrown hairs and nails, abrasions, itching caused by hemorrhoid inflammation, swellings, burns, frostbite, insect bites, surface bedsores, etc.How to apply FLOGO ointment?The ointment is only applied externally onto clean and disinfected skin! Do not apply the ointment to deep open wounds!Opening the tube and applying the ointment: for your safety, the ointment in the metal tube is sealed. Remove the cap from the tube, turn it upside down and use its pin to open the tube. Do this steadily without applying too much pressure to the body of the tube, so you are able to fully control how the ointment is squeezed out. Then gently apply the desired amount of ointment directly to the skin and/or mucous membrane in a thick layer (do not rub in) 2 to 3 times a day. Repeat the procedure until the skin and/or mucous membrane condition is improved.

Enzymatic Complex in a buffer solution (FLOGO Natural Enzymatic Complex).The natural enzyme complex causes a non-specific immune reaction at the point of administration. This intensifies immune response of the cell, which triggers the mechanism for production of defensive substances which fight the causes of infection and thus consequently reduce and prevent the further development of changes on the skin and mucous membranes. They have an anti-inflammatory effect, relieve unpleasant symptoms caused by pathological skin and mucous membrane changes, stimulate regeneration of damaged tissue, and accelerate wound healing.

Vitamin E acetate (Tocopherolis acetas) is the best known antioxidant that protects cell membranes from the damaging effects of freeradicals, increases moisture of the surface layer of the skin and its capacity to bind water.Lavender essential oil (Lavandulae aetheroleum) contains linalyl acetate, linalool, tannins, flavonoids, and phytosterols. It has an antiseptic and anti-inflammatory effect in skin diseases and inflammations. It speeds up healing of wounds and burns.Boric acid (Acidum boricum) is an efficient antiseptic which prevents secondary bacterial infection. It has an anti-inflamma-tory effect – decreases inflammation, soothes the skin, and relieves itching.

NOTE: Keep away from children!After direct contact of the ointment with the hands, wash the hands thoroughly.Avoid contact with eyes. If the ointment comes into contact with eyes, wash your eyes with lukewarm water and lukewarm camomile tea.

When to apply FLOGO ointment?Because of its composition and action, FLOGO ointment is fast and efficient in relieving all inflammatory skin and cutaneous mucous membrane conditions – therefore, our product is one of the top products for external use.It is used for reducing inflammation of eczematous skin, boils, acne and spots, ingrown hairs and nails, abrasions, itching caused by hemorrhoid inflammation, swellings, burns, frostbite, insect bites, surface bedsores, etc.How to apply FLOGO ointment?The ointment is only applied externally onto clean and disinfected skin! Do not apply the ointment to deep open wounds!Opening the tube and applying the ointment: for your safety, the ointment in the metal tube is sealed. Remove the cap from the tube, turn it upside down and use its pin to open the tube. Do this steadily without applying too much pressure to the body of the tube, so you are able to fully control how the ointment is squeezed out. Then gently apply the desired amount of ointment directly to the skin and/or mucous membrane in a thick layer (do not rub in) 2 to 3 times a day. Repeat the procedure until the skin and/or mucous membrane condition is improved.

Enzymatic Complex in a buffer solution (FLOGO Natural Enzymatic Complex).The natural enzyme complex causes a non-specific immune reaction at the point of administration. This intensifies immune response of the cell, which triggers the mechanism for production of defensive substances which fight the causes of infection and thus consequently reduce and prevent the further development of changes on the skin and mucous membranes. They have an anti-inflammatory effect, relieve unpleasant symptoms caused by pathological skin and mucous membrane changes, stimulate regeneration of damaged tissue, and accelerate wound healing.

61VADEMECUM

Relieves the symptoms of skin andmucous membrane inflammation

DERMOCOSMETIC PRODUCTS

FLOGO OINTMENT

Paraben-free formula, with no artificial colors or perfumes – with a herbal fragrance and 100% lavender essential oilCharacteristics of FLOGO ointment• ntiseptic, anti-inflammatory• regenerative, protective, emollient emulsifying ointment• nutritive and contains vitamins Essential ingredients of FLOGO ointment• Enzyme complex in buffer solution (FLOGO Natural Enzymatic Complex)• Calendula oil (Calendulae oleum) • Almond oil (Amygdalae oleum)• Vitamin E acetate (Tocopherolis acetas)• Lavender essential oil (Lavandulae aetheroleum)• Boric acid (Acidum boricum)

Expiry date of FLOGO ointment?Two years from the date of manufacture. Batch number and expiry date can be seen on the packaging. How to store FLOGO ointment? At temperatures up to +25°C. What does the original packaging of FLOGO ointment look like?Metal tube containing 50 g of ointment in a cardboard box.Who produces FLOGO ointment and takes care of you?Veterinarski zavod Subotica a.d. in cooperation with Lilifarm d.o.o, Belgrade

Calendula oil (Calendulae oleum) is a natural emollient with complex composition, which among other things contains carotene and other carotenoids, flavonoids, glycosides, triterpene alcohols, sterols, and tannins. It has an intense antiphlogis-tic and disinfectant effect on the skin and mucous membranes in cases of cuts, infected wounds, burns, boilsAlmond oil (Amygdalae oleum) is a traditional natural emollient. It contains oleic and linoleic acid – essential unsaturated fatty acids needed for metabolism, tone, nutrition, and skin protection. Hydrates the skin, increases its elasticity and freshness.

Evening primrose oil (Oenothera biennis oleum) was traditionally used by Indians of South America to heal skin illnesses and wounds. It is mentioned in the 17th century English literature as THE KING’S CURE-ALL. It has been an ingredient in preparations for treating eczema and dry skin since the 1930s. Evening primrose oil contains, among other things, 75% of linoleic and 9% of gamma-linoleic acid, so this oil is considered to be the richest source of essential fatty acids (also known as vitamin F).Fish oil (Jecoris oleum), natural emollient, contains a high percentage of mono- and polyunsaturated essential fatty acids – omega-3, the most important of which are DHA and EPA, which reduces the production of sebum and demonstrates a strong anti-inflammatory effect. It is a natural source of essential vitamins A and D3 necessary for accelerated metabolism, epithelialization, and skin regeneration. Improves the condition of dry, rough skin and stimulates its hydration.Vitamin E acetate (Tocopherolis acetas) is the best known antioxidant that protects cell membranes from the damaging effects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.Zinc oxide (Zinci oxydum) is an efficient adsorbent and astringent, therefore it has a significant role in healing and epitheli-alization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.Titanium dioxide (Titanii dioxydum) is a natural pearlescent pigment which creates a protective film on the skin surface and accelerates epithelialization. Together with zinc oxide, it forms the most popular physical UV filter and protects the skin from harmful effect of the sun and other burns.Bergamot essential oil (Bergamotte aetheroleum) contains limonene, linalilacetate, linalool, and γ-terpinene. It has an antiseptic and stimulative effect. It relieves the symptoms of inflamed acne, eczema, psoriasis, herpes, insect bites, and muscle pains.When to apply Zinc-vitamin ointment?In every home it is a "first-aid ointment" for external use! It helps with: relieving the symptoms of acne and sensitive skin, in case of bedsores, burns, abrasions, skin redness, rashes, itching, and also after intensive sunbathing.

NOTE: Keep away from children!After direct contact of the ointment with the hands, wash the hands thoroughly. The ointment may stain clothes!Avoid direct contact of the ointment with eyes! If the ointment comes into contact with eyes, wash your eyes with lukewarm water and lukewarm camomile tea. If the redness persists for a longer period of time, consult a doctor.Expiry date of Zinc-vitamin ointment?Two years from the date of manufacture. Batch number and expiry date can be seen on the packaging.How to store Zinc-vitamin ointment?At temperatures up to +25°C.

How to apply Zinc-vitamin ointment?The ointment is only applied externally onto clean and disinfected skin! Do not apply the ointment to open wounds! Opening the tube and applying the ointment: for your safety, the ointment in the metal tube is sealed. Remove the cap from the tube, turn it upside down and use its pin to open the tube. Do this steadily without applying too much pressure to the body of the tube because the content of the tube may suddenly come out. Then gently squeeze out the desired amount of ointment and apply it directly to the affected area. Rub the ointment evenly by gentle movement of the fingertips.

Evening primrose oil (Oenothera biennis oleum) was traditionally used by Indians of South America to heal skin illnesses and wounds. It is mentioned in the 17th century English literature as THE KING’S CURE-ALL. It has been an ingredient in preparations for treating eczema and dry skin since the 1930s. Evening primrose oil contains, among other things, 75% of linoleic and 9% of gamma-linoleic acid, so this oil is considered to be the richest source of essential fatty acids (also known as vitamin F).Fish oil as vitamin F).Fish oil as vitamin F).

(Jecoris oleum), natural emollient, contains a high percentage of mono- and polyunsaturated essential fatty acids as vitamin F).

(Jecoris oleum), natural emollient, contains a high percentage of mono- and polyunsaturated essential fatty acids as vitamin F).

– omega-3, the most important of which are DHA and EPA, which reduces the production of sebum and demonstrates a strong anti-inflammatory effect. It is a natural source of essential vitamins A and D3 necessary for accelerated metabolism, epithelialization, and skin regeneration. Improves the condition of dry, rough skin and stimulates its hydration.Vitamin E acetate (Tocopherolis acetas) is the best known antioxidant that protects cell membranes from the damaging effects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.Zinc oxideeffects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.Zinc oxideeffects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.

(Zinci oxydum) is an efficient adsorbent and astringent, therefore it has a significant role in healing and epithelieffects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.

(Zinci oxydum) is an efficient adsorbent and astringent, therefore it has a significant role in healing and epithelieffects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.

-alization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.Titanium dioxidealization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.Titanium dioxidealization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.

(Titanii dioxydum) is a natural pearlescent pigment which creates a protective film on the skin surface alization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.

(Titanii dioxydum) is a natural pearlescent pigment which creates a protective film on the skin surface alization processes of damaged skin. It quickly eliminates redness, reduces skin irritation, and efficiently soothes the skin.

and accelerates epithelialization. Together with zinc oxide, it forms the most popular physical UV filter and protects the skin from harmful effect of the sun and other burns.Bergamot essential oil (Bergamotte aetheroleum) contains limonene, linalilacetate, linalool, and γ-terpinene. It has an antiseptic and stimulative effect. It relieves the symptoms of inflamed acne, eczema, psoriasis, herpes, insect bites, and muscle pains.When to apply Zinc-vitamin ointment?In every home it is a "first-aid ointment" for external use! It helps with: relieving the symptoms of acne and sensitive skin, in case of bedsores, burns, abrasions, skin redness, rashes, itching, and also after intensive sunbathing.

NOTE: Keep away from children!After direct contact of the ointment with the hands, wash the hands thoroughly. The ointment may stain clothes!Avoid direct contact of the ointment with eyes! If the ointment comes into contact with eyes, wash your eyes with lukewarm water and lukewarm camomile tea. If the redness persists for a longer period of time, consult a doctor.Expiry date of Zinc-vitamin ointment?Two years from the date of manufacture. Batch number and expiry date can be seen on the packaging.How to store Zinc-vitamin ointment?At temperatures up to +25°C.

How to apply Zinc-vitamin ointment?The ointment is only applied externally onto clean and disinfected skin! Do not apply the ointment to open wounds! Opening the tube and applying the ointment: for your safety, the ointment in the metal tube is sealed. Remove the cap from the tube, turn it upside down and use its pin to open the tube. Do this steadily without applying too much pressure to the body of the tube because the content of the tube may suddenly come out. Then gently squeeze out the desired amount of ointment and apply it directly to the affected area. Rub the ointment evenly by gentle movement of the fingertips.

62VADEMECUM

Accelerates epithelialization,drying, and healing of wounds Regenerates the skin

DERMOCOSMETIC PRODUCTSZINC-VITAMIN OINTMENT

Paraben-free formula, with no artificial colors or perfumes – with the natural fragrance of 100% Bergamot essential oil Characteristics of Zinc-vitamin ointment• regenerative • adsorbent-astringent • nutritive, emollient, and protective

• accelerates granulation Essential ingredients of Zinc-vitamin ointment• Evening primrose oil (Oenothera biennis oleum)• Fish oil (Jecoris oleum)• Vitamin E acetate (Tocopherolis acetas)• Zinc oxide (Zinci Oxydum)• Titanium dioxide (Titanii Dioxydum)• Bergamot essential oil (Bergamotte aetheroleum)

What does the original packaging of Zinc-vitamin ointment look like?Metal tube containing 50 g of ointment in a cardboard box.Who produces Zinc-vitamin ointment and takes care of you?Veterinarski zavod Subotica a.d. in cooperation with Lilifarm d.o.o, Belgrade

• relieves the symptoms of skin and mucous membrane inflammation processes

63VADEMECUM

Improves circulation and skin regenerationParaben-free formula, with no artificial colors, or perfumes – with the original fragrance and color of camphor and ichthyolCharacteristics of IHTIOL-KAMFOR ointment• rubefacient, antiseptic• regenerative, protective and emollient • nutritive and contains vitaminsEssential ingredients of IHTIOL-KAMFOR ointment• Ichtyol (Ammonii sulfogyrodalas)• Fish oil (Jecoris oleum)• Camphor (Camphora)• Hypericum oil (Hyperici oleum)• Vitamin E acetate (Tocopherolis acetas)

Expiry date of IHTIOL-KAMFOR ointment?Two years from the date of manufacture. Batch number and expiry date can be seen on the packaging.How to store IHTIOL-KAMFOR ointment?At temperatures up to +25°C.What does the original packaging of IHTIOL-KAMFOR ointment look like?Metal tube containing 50 g of ointment in a cardboard box.Who produces IHTIOL-KAMFOR ointment and takes care of you?Veterinarski zavod Subotica a.d in cooperation with Lilifarm d.o.o, Belgrade

Relieves the symptoms of inflammationof tendons, joints, and soft tissue

DERMOCOSMETIC PRODUCTSIHTIOL-KAMFOR OINTMENT

Ichthyol (Ammonii sulfogyrodalas) has been traditionally known for almost 100 years, it is a natural source of organical-ly-bound sulfur (high overall concentration of sulfur) with anti-inflammatory, antibacterial, antimycotic, and antiseborrheic effect.

Camphor (Camphora) is the best-known rubefacient which improves circulation and is used as an irritant for rubbing in for pains and swelling (in case of rheumatic pains, myalgia, neuralgia). It is extremely efficient for improving the circulation of acned and seborrheic skin.Hypericum oil (Hyperici oleum) is traditionally known as an antiseptic and an astringent that people have been using for years in treating burns, cuts, and in healing wounds. It has a complex composition and contains, among other things, polyphenols, flavonoids, catechin tannins, antibiotic substances. It soothes pain and is recommended in case of muscle injuries, tissue contusions, boils, and swelling. The emollient oil stimulates tissue regeneration and accelerates the skin metabolism.Vitamin E acetate (Tocopherolis acetas) is the best known antioxidant that protects cell membranes from the damaging effects of free radicals, increases moisture of the surface layer of the skin and its capacity to bind water.

When to apply IHTIOL-KAMFOR ointment?Because of its composition and action, IHTIOL-KAMFOR ointment is fast in relieving inflammatory and painful conditions of the tissue, joints, soft tissues, boils, seborrhea, eczema, and psoriasis.How to apply IHTIOL-KAMFOR ointment?The ointment is only applied externally onto clean and disinfected skin! Do not apply the ointment to damaged skin and open wounds.Opening the tube and applying the ointment: for your safety, the ointment in the metal tube is sealed. Remove the cap from the tube, turn it upside down and use its pin to open the tube. Squeeze out the ointment steadily, without applying too much pressure to the body of the tube. Then gently apply the appropriate amount of ointment and rub it in properly. Repeat until there is visible improvement of the condition. You can cover the treated area with gauze or bandage.NOTE: Keep away from children!After direct contact of the ointment with the hands, wash the hands thoroughly. The ointment can stain clothes!Avoid direct contact of the ointment with the eyes! If the ointment comes into contact with eyes, wash your eyes with lukewarm water and lukewarm camomile tea. If the redness persists for a longer period of time, consult a doctor.

Fish oil (Jecoris oleum), natural emollient, contains a high percentage of mono- and polyunsaturated essential fatty acids –omega-3, most important of which are DHA and EPA, which reduces the production of sebum and demonstrates a strong anti-inflammatory effect. It is a natural source of essential vitamins A and D3 necessary for accelerated metabolism, epitheliali-zation, and skin regeneration. Improves the condition of dry, rough skin and stimulates its hydration.

64VADEMECUM

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65VADEMECUM

NOTES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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66VADEMECUM

NOTES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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VETERINARSKI ZAVOD SUBOTICA A.D.Beogradski put 12324106 Subotica, SerbiaPhone: +381 (24) 624 100,Fax: +381 (24) 567 736,[email protected]: www.vetzavodsubotica.rs

Documents

· GOPAVAK is a monovalent vaccine against salmonellosis of pigeons. It contains formalin inactivated cultures of immunogenic bacterial strain Salmonella typhimurium var. Copenhagen,