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With the growing demand for information about comparative effectiveness and questions about the quality of research that will support future health care decision-making, a group of researchers led by Quintiles and the National Pharmaceutical Council have developed and tested a checklist to evaluate the quality and usefulness of observational research studies. The Good ReseArch for Comparative Effectiveness (GRACE) checklist was published as part of a peer-reviewed study, "The GRACE Checklist for Rating the Quality of Observational Studies of Comparative Effectiveness: A Tale of Hope and Caution," that was published in the March 2014 issue of Journal of Managed Care & Specialty Pharmacy.We've summarized the research in this handy infographic.
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ASSESSING OBSERVATIONAL STUDIESObservational studies follow patients over time and can evaluate the of interventions on health outcomes
STRENGTHS OF OBSERVATIONAL STUDIES
DIVERSE POPULATIO
NS
Pro
vi
de information about
PATIENT-CENTERED OUTCO
ME
S
Impr
ove understanding of
REAL WORLD SETTIN
GS
Tell
us
how treatments work in
- TIMELY RESULTS
Can
be
conducted more quickly for
There is growing demand for comparative ectiveness research (CER) and how interventions work in the real world. Yet there is debate about whether and when observational studies are good enough to support decision-making.
LIMITATIONS OF OBSERVATIONAL STUDIES
Many factors drive
TREATMENT DECISIO
NS
Rea
l-world patients can have
CO
MPLEX CLINICAL CONDIT
ION
S
Som
e studies must address
UNBALANCED GROUPS, DIFFERENTIAL FOLLOW-U
P
AND MISSING DATA
A HELPFUL TOOLWhen done correctly, observational studies can provide meaningful information; when done poorly, misinterpretations are possible. The Good ReseArch for Comparative (GRACE) Checklist was developed as a guide to assess the quality of observational studies and to help ensure that the information used is credible and reliable.
GRACE CHECKLIST*
*This is an abridged version of questions in the GRACE checklist.For more information, check out the March 2014 Journal of Managed Care Pharmacy.
DATA METHODS
Source: Dreyer NA, Velentgas P, Westrich K, Dubois RW. The GRACE Checklist for Rating the Quality of Observational Studies of Comparative J Manag Care Pharm. 2014;20(3):1-12.