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NR1. NR2. allosteric modulators site 1. site 2 ?. N-terminal domains (NTDs). Zn 2+ (NR2A>>NR2B) ifenprodil (NR2B). site 3 ?. agonist -binding domains (ABDs). competitive agonists and antagonists. glycine (or D-serine). glutamate. site 4 ?. pore blockers. pore domains. 4. - PowerPoint PPT Presentation
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glutamateglycine(or D-serine)
NR2
Zn2+ (NR2A>>NR2B)ifenprodil (NR2B)
NR1
N-terminaldomains
(NTDs)
agonist-bindingdomains
(ABDs)
poredomains
C-terminaldomains
allostericmodulatorssite 1
competitive agonistsand antagonists
3
2
14
poreblockers
site 3 ?
site 4 ?
site 2 ?
2
413
