Document GFAR-MTM-02–16

Global Partnership Programme:

Trypanosomosis Control

G F A RF M R AF G I A

LOBAL ORUM ON GRICULTURAL ESEARCHORUM ONDIAL DE LA ECHERCHE GRICOLEORO LOBAL DE NVESTIGACION GROPECUARIA

Global Partnership Programme

Global PartnershipProgramme

Genetic Resource Managementand Biotechnology

TrypanosomosisControl

GFAR

Global Partnership Programme

TITLEA Global Initiative to exploit biotechnology and animalgenetic resources for the improvement of livestockproductivity through control of trypanosomosis.

DURATION5 years

OBJECTIVESIncrease productivity through integratedcontrol of trypanosomes

Improved food security

Poverty alleviation

JUSTIFICATIONTrypanosomosis is a major constraint to livestockproductivity in Africa, Asia and Latin America.Economic losses are estimated at $ 4 billion annually inAfrica and 300,000 new cases of human sleepingsickness each year.

Global Partnership Programme

HISTORY of GLOBAL INITIATIVE (1/2)November 1999 : CIRAD-EMVT proposed a GlobalInitiative on Tryps

January 2000 : joint meeting CIRAD-ILRI in France.Participants : PAAT, ICTPV

OIE NTTATGFAR secretariatIRD, University of Montpellier

Discussion and preparation of Proposal.

December 1999 : discussions with ILRI

March 2000 : Proposal sent to every institution,scientist working on tryps in

Africa (PAAT)Asia (ILRI)Latin America (Trytplink)

April 2000 : more than 50 positive answers

May 2000 : Presentation of the Global Proposal toGFAR at Dresden by Dr Adama TRAORE (CORAF).Very positive welcome.

October 2000 : framework for proposals by GFARSecretariat

Global Partnership Programme

HISTORY of GLOBAL INITIATIVE (2/2)

2001 : Stand-byWhat to do ? How ?

January 2002 : Questionnaire to partnersCurrent status of research activities* Current projects* Future projects

May 2002 : Presentation of proposal to EFARD

PAAT meeting at ILRI (Kenya) with African partners +representatives from Latin America and Asiato build a Project.

Next step : meeting with donors …

March 2002 : Analysis of questionnaires

FUTURE of GLOBAL INITIATIVE

Global Partnership Programme

ACTIVITIES

Strategic research using modern tools ofbiotechnology and genetics.1

Develop novel vaccines :anti-diseaseanti-parasite

2 Develop sustainable decision-supporttools for integrated control

Better use of chemotherapy (cost/benefit)

3 Capacity building

Develop and apply affordable, specific & rapiddiagnotic tests

Better use of trypanotolerant animals

Develop decision support tools based on riskassesment

Improve the control of parasites in livestockand human populations

Global Partnership Programme

MAIN INNOVATIONS

Link the experience and research agendas ofscientists & institutions from Africa, Asia andLatin America.

Integrate research on the parasites ofeconomical importance :

Trypanosoma congolense : livestock / Africa

Integrate research products on diagnostic,epidemiology, chemotherapy, immunology,vaccines and resistant animals...

Improve human welfare with most advancedtools of biotechnology and basic researchoutputs.

T. evansi : livestock / Africa / Asia / AmericaT. brucei : livestock / man /Africa

T. vivax : livestock / Africa / America

Global Partnership Programme

PAAT / GFAR

PAAT : Programme Against African Trypanosomosis

Proposed by FAO to :

“promote and facilitate integrated and effectivecontrol of trypanosomosis”

within the overall goal of a “sustainable increase ofincome, food security and human welfare intrypanosomosis affected areas of Africa”.

But limited available resources

GFAR : Global Forum on Agricultural Research

Provide support required to initiate, strengthenand sustain essential research activities atnational and regional levels.

.PAAT as a basis for an extended global initiative indeveloping countries of South America and Asia

.GFAR as providing research support to PAAT

Global Partnership Programme

RESULTS & IMPACT

A community of research institutions, privatesector, national and international agencies.

Main expected results :

Strategic research / biomedical research forsolutions including diagnostic tests, vaccinesand improved use of animal genetics

Birth / death rate in endemic areasProposed impact assessment methodology :

Farming as a more sustainable, economicallyviable and environmentally friendly activity.

Voluntary disposal of surplus stockAge / sex distribution of animals / herdsNumber and type of plough animals usedQuantity of trypanocides soldEpidemiological surveysGlobal increase of animal production

Global Partnership Programme

1-3 leaders

Steering Committee with rotation of members

Flexible organization : new partners to enterat any time

Small and lean Executive Secretariat :

GUIDING PRINCIPLES

FOR MANAGING GPP

Information and Communication betweenpartners and outsidePriority setting : research priorities

Donor relations : common rule = cost-sharing

Public awareness : cost / benefits

Monitoring of activities

Valorisation and wide dissemination of results

Global Partnership Programme

PARTNERS

N.B.: Category: NARS, ARI, IARC, NGO, FO, PS, Donor

Lead Stakeholder Name of contact personCategory Corporate Name

IARC CIRDES Marc DesquesnesIARC ITC Kwaku AgyemangIARC OCEAC Gerard CunyNARS Brazil Claudio MadrugaNARS Bolivia NARS South Africa Theresa CoetzerNARS MaliNARS PhilippinesNARS Malaysia Dr.Chandrawathani PanchadcharamNARS EthiopiaNARS Nigeria - NITR NARS KETRI Joseph Mathu NdunguNARS LHRI Uganda William Olaho-MukaniNARS Univ. Nigeria Denis OnahNARS Univ. Simon Bolivar Pedro AsoNARS Inst. Oswaldo Cruz Alberto DavilaNARS CORPOICA Efrain BenavidesNARS Univ. In India Veer SinghNARS Fac. Mymensingh Motahar Hussain MondalNARS NIAH – Thailand Darunee TuntasuvanNARS NIVR – Vietnam Le Ngoc MyNARS Vet. Lab.., RD Congo Leopold K. Mulumba-MARI Univ. Changchun Zhang XichenARI Univ. Murdoch Simon ReidARI Univ. Manchester Keith GullARI Univ. Libre Bruxelles Etienne PaysARI Free Univ. Bruxelles Patrick De BaetselierARI IMT Antwerp Stanny GeertsARI Univ. Massachusetts Samuel BlackARI Univ. Liege Charles MichauxINT ORG ICIPE Rajinder, SainiINT ORG OIE NTTAT Group Louis TouratierINT ORG PAAT Peter HolmesINT ORG ISCTRC Solomon Haile MariamINT ORG WHO (EC)INT ORG FAO/AIEA U. FeldmannINT ORG FAO Raffaele Mattioli

Global Partnership Programme

CONCLUSION.

These new tools will be associated toexisting methods :

Produce new diagnostics

Need for new tools to alleviatetrypanosomes-induced constraints to :

Disseminate resistant animals

Chemotherapy

Vectors control

The proposed Forum will create a synergybetween different groups involved in basicand applied research.

Produce novel vaccines