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�è �Why GISRS?
• GISRS is a unique worldwide network able to rapidly identify and respond to influenza outbreaks including those with pandemic potential.
• Influenza viruses, both seasonal and zoonotic, con-stantly evolve and change.
• Influenza surveillance and virus monitoring are key to timely detect and mitigate influenza outbreaks through vaccination and antiviral therapy.
�è �GISRS: a unique network built over
60 years
Established in 1952, GISRS currently comprises:• 142 National Influenza Centers• 6 WHO Collaborating Centers• 4 WHO Essential Regulatory
Laboratories• 13 WHO H5 Reference
Laboratories
Technical and scientific resource for WHO public health policy making
è �Mission of GISRS
• Surveillance and monitoring of seasonal and emerging influenza viruses;
• Recommendations in areas including laboratory diag-nostics, vaccines and antiviral susceptibility;
• Risk assessment for seasonal and pandemic influ-enza; and
• Detection and response to influenza outbreaks.
Global Influenza Surveillance and Response System (GISRS)
WHO�GISRS�as of 28 November 2014
National Influenza CentreWHO Collaborating Centre for Reference and Research on Influenza WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory 0 1,750 3,500875 KilometersNot applicable
National Influenza CentreWHO Collaborating Centre for Reference and Research on InfluenzaWHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza
National Influenza CentreWHO Collaborating Centre for Reference and Research on Influenza WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory 0 1,750 3,500875 KilometersNot applicable
National Influenza CentreWHO Collaborating Centre for Reference and Research on Influenza WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory 0 1,750 3,500875 KilometersNot applicable
WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory
National Influenza CentreWHO Collaborating Centre for Reference and Research on Influenza WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory 0 1,750 3,500875 KilometersNot applicable
National Influenza CentreWHO Collaborating Centre for Reference and Research on Influenza WHO Collaborating Centre for the Surveillance, Epidemiology and Control of Influenza WHO Collaborating Centre for Studies on the Ecology of Influenza in AnimalsWHO Essential Regulatory LaboratoryWHO H5 Reference Laboratory 0 1,750 3,500875 KilometersNot applicable
The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concern-ing the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement.
Data source: GISRS, WHO
© World Health Organization 2015. All rights reserved.
1. Global surveillance and monitoring of influenza
2. Scientific evidence for policies
3. Global mechanism for emerging viruses
4. Information sharing and networking
So that… circulation and evolution of influenza viruses infecting humans are timely detected, monitored and assessed.
So that… real-time information is disseminated to public and collaboration among partners is strengthened.
So that… countries are provided with effective recommendations and are ready to respond to epidemics and pandemics.
So that… the world is adequately prepared for emerging threats and potential pandemics are mitigated.
�è �4 strategic axes Major achievements
• WHO External Quality Assessment Project for detecting influenza viruses by PCR.
• Updated inventory of candidate vaccine viruses and potency reagents for seasonal and zoonotic influenza.
• Real-time surveillance information sharing by GISRS through FluNet (www.who.int/flunet).
• Fortnightly web update on ‘global influenza activity’. • Web-based collaboration platform for GISRS laboratories.
• Timely scientific information, analysis and risk assessment. • WHO recommendations on the composition of seasonal in-
fluenza virus vaccines bi-annually and on the timely develop-ment of vaccines for zoonotic influenza viruses.
• Real-time virus monitoring by GISRS laboratories. • Timely virus sharing to allow characterization of the viruses
and development of control measures.• Guidance on laboratory methodology including Polymerase
Chain Reaction (PCR) for virus detection. • Advice on methodologies for GISRS surveillance including
antiviral susceptibility.
WHO contacts
Dr Sylvie BriandDirectorTel: + 41 22 791 2372Email: [email protected]
Dr Wenqing ZhangCoordinator a.i.Global Influenza Programme and PIP Framework Tel: + 41 22 791 4282Email: [email protected]
Data source: FluNet ( www.who.int/flunet ), GISRSGenerated on 09/12/2014 13:30:50 UTC
Global�circulation�of�influenza�viruses�(2008�-�2014)Number of specimens positive for influenza by subtype
The department of Pandemic and Epidemic Diseases (PED) develops strategies, initiatives, and mechanisms to address priority emerging and re-emerging epidemic diseases, including outbreaks, thereby reducing their impact on affected populations and limiting their international spread.
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More information is available on the WHO website:http://www.who.int/influenza/gisrs_laboratory/en/
