Give your gum disease the full treatment.

At the root of gum disease is infection caused by bacteria. And like many infections, gum disease can be tl~eated with an antibiotic. Unlike antibiotics that are swallowed, ARESTIN® is a powder that your dental professional

places directly into the Infected areas-or pockets-in your gums when you receive scaling and root planing (SRP).

ARESTIN® powder contains 100,000 t iny mlcrospheres, invisible to the eye.These microspheres contain the antibiotic drug minocycline, which is released over time into the infected pocket. This means ARESTIN ® keeps fighting disease-causing bactena aftel- you've left the dentist's chaJt~

Information enclosed.

Gum disease creates pockets between the teeth and gums.

Gum disease can cause your gums to bleed or become infected, swollen, or tendel~ As a result, the Infected gum starts to separate from the tooth.

Infected Tooth/Gum Periodontal Pocket

The gap between the gum and the tooth is known as a pocket that can become deeper over t ime. And thi s may I-aise your nsk of permanent damage.

Where do your pockets fallon this chart?

"1 mm 2. mm :1 nlm 4 rnm 5mm 6mm 7mm 8mm Smm+

• . ­yU l )

SAFE ZONE WARNING ACT NOW HIGHEST RISK OF TOOTH LOSS

\~------------------------------------------~)

A pocket of 4 mm or more in depth may mean you have an infection.

ARESTIN" (mmocy:lne hydl-ochlonde) Mluosphe·-es. I mg is Indicated as an adjl. '1c to scaling and

root planing (SRP) procedllres for l-eCUCIon of pOcket dep h in pa-ien - wi h adult periOdontitis.

ARESTIN" may De used as part of a periodontal program which Includes "ood oral hygiene and SRP

ARESTI ~ cont Ins mlnocyc line. a te~r cycline derivative .and therefore should not be used in ch ildren

and pregnant 0 1' nUl-sing women. The use of drugs of the tet,'acycJine class dunng tooth development

'lay cause permanent discolol-atio" of he t eeth. Ti'e n'ost common treatment--emel'gent adverse

eve ',~s wer-e leadache (9.0%), Infecti (7.6%). flu syndrome (5 0%), and Daln (43%). These occulTed

a a slmllal- rate to SRP and SRP + Dlacebo.

ARESTIN® contains minocycline, a tetracyc line derivative, and therefore should not be

used in chi ldren and in pregnant or nursing women.

ARESTlN®+ SRP is nearly 3 times more likely to result in successful treatment than SRP a/one.

Scaling and root planing can I-emove much of the plaque below your gUI line, w here bacteria produce the toxins that irritate your gums and cause infections. But SRP alone IS often not enough to finish the job.

A dding ARESTIN® helps kil l the bacteria that SRP can't reach.

ARESTIN® is shown to:

• Significantly reduce the size of pockets, compared with SRP alone • Kil l the bacteria most commonly associated with periodontal disease • Reduce bleeding on probing of the gums

ARESTlN® and SRP work together.

I Your dental professional w ill • remove plaque and tartar using SRP

2. ARESTIN® microspheres are painlessly added to infected pockets using a special plastic applicator.

3. Antibiotics are re leased over time, helping to keep bacteria from returning w hile your gums heal.

Are~#'4#;rt~.~l Kill the bacteria that cause gum ~U•• ~ \.~

disease. Choose ARESTIN®. minocycli ne Hel 1mg MICROSPHERES

~IOp 'Ighi Tap left

Bottom nght Bottom left

Your dentist will mark your infected pockets on this tooth diagram.

Ask wh ich areas YOUI- dentist recommends treating w ith A RESTIN@

Notes:

Your Next Appointment:

Date / /

Time

After your ARESTlN!i treatment:

o Wait at least 10 days before uSing fl oss, t oothpi cks, 0 1- ot her devices designed t o clean between teeth in treated areas

o Don't touch t reat ed areas for I week

o Avo id eating hard, crunchy, or sticky foods for I week

o Begin flossing again on _____________

Follow up w ith your dentist and your dental hygienist by keeping your scheduled appointments. Start and maintain a good oral care routine.