A Breakthrough Treatment for Gingivitis Gingival Disease Over 50 percent of American adults have significant periodontal disease.* "Gingivitis is the most common form of oral inflammatory disease followed by periodontitis. It is characterized by bleeding, swollen, and painful gums. It is a combined infectious and inflammatory process that has local destructive effects and can affect the overall health of the body. Fetal health, osteoporosis, cardiac health, arthritis, respiratory infections and diabetes, among others, have all been associated with oral inflammation. This systemic impact establishes oral inflammatory diseases as a major public health issue. Treating inflammation may not only help manage periodontal diseases but may also help with the management of other chronic inflammatory conditions."** Why We Need PeriActive TM Gingivitis is a chronic problem and current therapy that treats only the behavior is insufficient. Izun has developed a COMPLETE approach to managing Gingivitis. PeriActive™ reduces plaque and actually soothes gums! * (NIH Publication No. 02-1142; 2007) ** American Academy of Periodontology 2009 Indications Sensitive, irritated gums Gums that bleed easily during brushing or flossing Bad breath A change in the color of the gums from healthy pink to inflamed red Dosage Rinse with half a capful (15 ML) 2x per day Pharmacology Strong dual action: Anti-plaque Protects and strengthens inflamed gums Regulatory Status EU: Medical Device Class I (93/42/EEC)

Gingival DiseaseGingival Disease Over 50 percent of American adults have significant periodontal disease.* "Gingivitis is the most common form of oral inflammatory disease followed

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A Breakthrough Treatment for Gingivitis

Gingival DiseaseOver 50 percent of American adults have significant periodontal disease.*

"Gingivitis is the most common form of oral inflammatory disease followed by periodontitis. It is characterized by bleeding, swollen, and painful gums. It is a combined infectious and inflammatory process that has local destructive effects and can affect the overall health of the body. Fetal health, osteoporosis, cardiac health, arthritis, respiratory infections and diabetes, among others, have all been associated with oral inflammation. This systemic impact establishes oral inflammatory diseases as a major public health issue. Treating inflammation may not only help manage periodontal diseases but may also help with the management of other chronic inflammatory conditions."**

Why We Need PeriActiveTM

Gingivitis is a chronic problem and current therapy that treats only the behavior is insufficient. Izun has developed a COMPLETE approach to managing Gingivitis. PeriActive™ reduces plaque and actually soothes gums!

* (NIH Publication No. 02-1142; 2007)

** American Academy of Periodontology 2009

Indications Sensitive, irritated gums

Gums that bleed easily during brushing or flossing

Bad breath

A change in the color of the gums from healthy pink to inflamed red

DosageRinse with half a capful (15 ML) 2x per day

PharmacologyStrong dual action:

Anti-plaque Protects and strengthens inflamed gums

Regulatory StatusEU: Medical Device Class I (93/42/EEC)

Page 2: Gingival DiseaseGingival Disease Over 50 percent of American adults have significant periodontal disease.* "Gingivitis is the most common form of oral inflammatory disease followed

Breakthrough anti-inflammatory mouth rinse for Gingivitis

Unique dual action - reduces bacterial plaque and protects and relieves inflamed gums

More effective than other leading brands in the prevention of Gingivitis*

Significant decrease in gingival inflammation as measured by Gingival Index (GI)**

Significant decrease in bacterial plaque as measured by the Plaque Index (PI)***

Alcohol-free

Pleasant tasting

Prevents bad breath

Adjunctive to current dental care

Does not stain teeth

Promotes natural healing

Izun Oral Care | One Rockefeller Plaza 11th floor, New York, N.Y. 10020 | Tel (877) 210 2621, www.izunoralcare.com

Efficacy of treatmentGingival Index**

0 CPC EO PeriActiveTM

% P

reve

ntio

n of

ing

iviti

s -

Efficacy of treatmentPlaque Index***

-10 CPC EO PeriActiveTM

% P

reve

ntio

n of

acte

rial P

laq

ue -

* Samuels N, Grbic JT, Saffer AJ, Wexler ID, Williams RC. Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Compend Contin Educ Dent. 2012 Mar;33(3):204-6, 208-11

PeriActiveTM

A Breakthrough Treatment for

Gingivitis

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2015