Stable Biocatalysis for Chemical Synthesis

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The rmoCa t® E s t e r a s e s - the leader in chiral resolution of esters, enantioselective transesterification and asymmetric synthesis of alcohols:

Hydrolysis and Transesterification

(±) -IVCO2R2

ThermoCat· H20

ThermoCat· R3OH

R1 -CO2R2 + Rr -C0 2 H

Ri -CO2R3 + Rr-C0 2 Rj

Esterification

ThermoCat· (±) - R r O H -

A c O ^ *

R/-OH

Ri*-OAc

T h e r m o C a t ® D e h y d r o g e n a s e s - ThermoGen's newest oxidoreductases are useful for transformations such as stereoselective reduction of ketones, diketones, or racemic aldehydes and resolution of racemic alcohols:

The rmoCa t® b i o c a t a l y s t s a re y o u r f a s t e s t r o u t e t o s e l e c t i v e t r a n s f o r m a t i o n s . These newly discovered biocatalysts - developed with ThermoGen's unique technology - are s tab le at both room and e leva ted temperatures. They are specifically formulated for efficient biocatalysis R&D and large-scale process implementation to help you easily solve your toughest catalysis challenges. Available in bulk or convenient multienzyme screening kits, ThermoCat® biocatalysts are:

• H igh ly Enant iose lec t ive

• Ex t reme ly Durab le

• Ideal for Chira l T rans fo rmat ions

Contact ThermoGen for more information on our super io r b ioca ta l ys ts , QuickScreen™ Kits, custom screening se rv i ces , and innova t i ve e n z y m e engineering services.

ThermoCat· HO H

R ^ R * R * . C H O R ^ ^ R 2

ThermoCat·

R3 ^CH2OH

R2

R1,R2 =alkyl,aryl

HO

R 1 ^ R 2

ThermoCat· HQ

RX R2

Ο

R2

Q u i c k S c r e e n ™ K i t s - A rapid screening system to determine which ThermoCat· biocatalyst is best in your application.

• QuickScreen™ Kit for Ester Hydrolysis

• QuickScreen™ Kit for Ester Synthesis in Organic Solvents

C u s t o m B i o c a t a l y s t S c r e e n i n g a n d D e v e l o p m e n t S e r v i c e s - A cost effective alternative to help you develop biocatalysis processes. Our experience in developing biotransformations can help you meet your development goals.

(Λ Thermos* à

ση 2225 W. Harr ison, Chicago, IL 60612

phone: (312)226-6500 fax: (312)226-9686

www: http://www.thermogen.com

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