Gesellschaft für Virologie und DVV der Viruskrankheiten · DVV 28th Annual Meeting of the Society for Virology Gesellschaft für Virologie und Deutsche Vereinigung zur Bekämpfung

DVV

28th Annual Meeting ofthe Society for VirologyGesellschaft für Virologie

und

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten

14–17 March 2018 Würzburg • GermanyUniversität Würzburg

© Congress-Tourismus-Wirtschaft Würzburg l Fotograf A. Bestle

© 88649465 l JiSign l Fotolia.com

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Table of ConTenTs

Welcome notes Conference chair .................................................................................................. 4 President of the Society for Virology ................................................................... 5 President of the Julius-Maximilians-Universität .................................................. 6

Organisation and imprint .................................................................................................. 7

Societies and meetings ..................................................................................................... 8

Keynote speakers, awards, poster prize committee and chair persons .......................... 9

Programme overviews ...................................................................................................... 10

Scientific programme Wednesday, 14 March ......................................................................................... 14 Thursday, 15 March ............................................................................................. 22 Friday, 16 March .................................................................................................. 30 Saturday, 17 March .............................................................................................. 40

Poster sessions Poster floor plan .................................................................................................. 44 Poster session overview ...................................................................................... 45 Poster session 1 ................................................................................................... 46 Poster session 2 ................................................................................................... 69 Poster session 3 ................................................................................................... 90

Sponsors ............................................................................................................................ 108

Industrial exhibition .......................................................................................................... 110

Floor plan .......................................................................................................................... 111

Media cooperations and scientific sponsors .................................................................... 112

General information ......................................................................................................... 113

Social programme ............................................................................................................. 115

Index of invited speakers, abstract authors and chair persons ........................................ 116

Upcoming conferences and meetings .............................................................................. 130

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WELCOME NOTE • CONFERENCE CHAIR

Dear colleagues,

It is with great pleasure to welcome you to the 28th Annual Meeting of the Society for Virology from 14–17 March 2018 at the Julius-Maximilians-Universität in Wurzburg.

As usual, the meeting covers a broad spectrum of virological topics in plenary sessions, work-shops and poster presentations. A particular focus of this meeting will be on new technological developments for basic research and clinical virology. A major aim of the meeting is to provide a platform for young scientists to present their work and ideas. Therefore, we welcome young researchers to join us and encourage all senior virologists to promote their mentees’ attendance.

The Institute of Virology and Immunology in Wurzburg, founded almost 50 years ago, has a long-standing history of interdisciplinary research in virology, cell biology and immunology. Following the establishment of the Research Center for Infectious Diseases in 1993, research in this field has been boosted by two recent exciting developments. In spring 2017, a new Helmholtz-Institute for RNA-based Infection Research (HIRI) was founded in Wurzburg, located at the heart of the new biomedical campus. In addition, new Max-Planck Research Groups in Systems Immunology will become operational in 2018. Together, these will start recruiting leading scientists and cutting-edge technologies for infection research to Wurzburg within the next few years.

We are convinced that we will have a very successful and stimulating 28th Annual Meeting of the Society for Virology in the beautiful city of Wurzburg. The organising committee is pleased to welcome you all in Wurzburg!

Best regards

Lars DölkenConference Chair

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WELCOME NOTE • PRESIDENT OF THE SOCIETY FOR VIROLOGY

Dear colleagues,

On behalf of all members of our board I warmly welcome you to the 28th Annual Meeting of the ”Gesellschaft fur Virologie” (GfV) in Wurzburg held together with the “Deutsche Vereini-gung zur Bekämpfung der Viruskrankheiten” (DVV).

The meeting covers all areas of virology from basic research to medical and veterinary virol-ogy, a large field of high scientific, epidemiological, medical and also social impact. In addition, virology is of course a cross-sectional discipline contributing to interdisciplinary research in many ways. The broadly based program of the 28th meeting highlights this unique character of virology at its best.

While the Annual Meeting is the undisputed summit of our society’s activities, the GfV is also very active throughout the year concerning many tasks. All achievements deserve credit, but only few can be appreciated at this point, e. g. the exciting meetings of our GfV study groups (“Arbeitskreise”) or the works of our expert panels (“Kommissionen”). However, since virol-ogy in Austria, Germany and Switzerland is facing new challenges the GfV is currently shaping new initiatives. These could include for instance a program to better train and attract young virologists or an improved curriculum upgrading PhDs to medical virologists competent in diagnostics and clinical virology. All GfV members are invited to discuss these important issues at the general assembly on Thursday, March 15, at 7 p.m.

By tradition, we shall award the Loeffler-Frosch-Prize this year to PhD Benedikt Kaufer, Free University of Berlin, and we will honor Prof. Dr. med. Otto A. Haller, former chair of virology at the University of Freiburg, who will receive the Loeffler-Frosch-Medal. Last but not least the joint prize for the best dissertation donated by the DZIF (Deutsches Zentrum fur Infektions-forschung) and the GfV will be presented on Thursday, March 15 during the plenary session.

I am convinced that we will have a very successful, challenging and scientifically stimulat-ing meeting. I want to thank our internationally renowned keynote speakers and deeply feel the need to give my special thanks to Prof. Dr. Lars Dölken as a Conference Chair, the local organizing committee, the scientific chair persons and the many volunteers for the work and responsibilities they have taken on to prepare and to perform this year’s highlight in virology.

Hartmut HengelPresident of the GfV

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WELCOME NOTE • PRESIDENT OF THE JULIUS-MAXIMILIANS-UNIVERSITÄT

Ladies and Gentlemen, dear Guests,

Julius-Maximilians-Universität (JMU) Wurzburg was originally founded in 1402 with the four traditional faculties of theology, law, medicine and philosophy. Today, the University of Wurz-burg has about 29,000 students in 10 faculties with a wide range of both traditional and mod-ern subjects.

Medicine is one of the major fields of JMU. This is emphasised by the fact that three eminent scientists and alumni of the University of Wurzburg have received the Nobel Prize for Medicine.

Our university has a long tradition in the field of virology and immunology, and many exciting developments in infection research can currently be observed at JMU.

Experiences with epidemics like Ebola, SARS and very recently with the Zika virus in Central and South America have vividly shown the importance of virology in the prevention, contain-ment and therapy of virus infections. The successful long-term control of such viral agents is only possible in strong national and international collaboration. Especially the interdisciplinary exchange as well as the involvement and advancement of young scientists are particularly well-suited to establish a basis for innovative research to develop new preventive and therapeutic approaches.

The Annual Meeting of the Society for Virology – which brings together over 1,000 virologists in Wurzburg this year – contributes significantly to the progress of scientific research in this field.

I wish all participants an interesting and stimulating meeting with many insights into new re-search perspectives, a lively and fruitful exchange with colleagues and international scientists, and a pleasant stay in Wurzburg. I hope you also find time to enjoy some marvelous spots of our beautiful city.

Alfred ForchelPresident

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ORGANISATION AND IMPRINT

VenueJulius-Maximilians-Universität WurzburgHörsaal-Gebäude Z6Am Hubland97074 Wurzburg (DE)

Organiser Gesellschaft fur Virologie e. V.(GfV, Society for Virology)www.g-f-v.org

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V. (DVV, German Association for the Control of Virus Diseases)www.dvv-ev.de

Organising committeeProf. Dr. Lars DölkenProf. Dr. Sibylle Schneider-SchauliesProf. Dr. Jürgen Schneider-SchauliesInstitute for Virology and ImmunobiologyVersbacher Straße 797078 Wurzburg (DE)

Conference organisationConventus Congressmanagement & Marketing GmbHMarlen Schiller/Ann-Kathrin SchulteCarl-Pulfrich-Straße 107745 Jena (DE)Phone +49 3641 31 16-358/-363Fax +49 3641 31 [email protected]

Design/LayoutLayout krea.tif-studio UG (haftungsbeschränkt)Print Siblog • Gesellschaft fur Dialogmarketing, Fulfillment & Lettershop mbHCirculation 1,000Editorial deadline 23 February 2018

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SOCIETIES AND MEETINGS

Executive committee of the Society for Virology (GfV, Gesellschaft für Virologie)President Hartmut Hengel (Freiburg/DE)Secretary Sigrun Smola (Homburg a. d. S./DE)Treasurer Klaus Überla (Erlangen/DE)Vice presidents Ralf Bartenschlager (Heidelberg/DE) Beate Sodeik (Hanover/DE)

Former presidents Thomas Mertens (Ulm/DE) Nikolaus Muller-Lantzsch (Homburg a. d. S./DE) Hans-Dieter Klenk (Marburg/DE) Otto Haller (Freiburg/DE) Bernhard Fleckenstein (Erlangen/DE)

Advisory board Stephan Becker (Marburg/DE) Wolfram Brune (Hamburg/DE) Ulf Dittmer (Essen/DE) Christian Drosten (Berlin/DE) Urs Greber (Zurich/CH) Klaus Osterrieder (Berlin/DE) Thomas Pietschmann (Hanover/DE) Elisabeth Puchhammer-Stöckl (Vienna/AT) Sibylle Schneider-Schaulies (Wurzburg/DE) Veronika von Messling (Langen/DE)

For more information and for membership application, please visit our website www.g-f-v.org.

Executive committee of the German Association for the Control of Virus Diseases(DVV, Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.)President Helmut Fickenscher (Kiel/DE)Vice president Heinz Zeichhardt (Berlin/DE)Secretary Ute Helling (Kiel/DE)Treasurer Barbara Gärtner (Homburg/DE)

Meetings of the Society for VirologyGfV Board Meeting Wednesday, 14 March 2018, 09.00–11.30(Vorstands- und Beiratssitzung) Hotel Melchior Park, Am Galgenberg 49

GfV General Assembly Thursday, 15 March 2018, 19.00–20.00(Mitgliederversammlung) Lecture Hall 1

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KEYNOTE SPEAKERS, AWARDS, POSTER PRIzE COMMITTEE AND CHAIR PERSONS

Keynote speakersA. Ablasser (Lausanne/CH)P. Bieniasz (New York, NY/US)B. Brugger (Heidelberg/DE)A. Davison (Glasgow/GB)N. Fischer (Hamburg/DE)K. Fruh (Portland, OR/US)G. Gabriel (Hamburg/DE)G. Gerold (Hanover/DE)K. Grunewald (Hamburg/DE)P. Lehner (Cambridge/GB)M. Obermeier (Berlin/DE)Y.-Z. Zhang (Beijing/CN)

AwardsLoeffler-Frosch-AwardB. Kaufer (Berlin/DE)

Loeffler-Frosch-MedalO. Haller (Freiburg/DE)

Poster prize committeeJ. Bodem (Wurzburg/DE)C. Goffinet (Hanover/DE)A. Halenius (Freiburg/DE)C. Scheller (Wurzburg/DE)J. von Einem (Ulm/DE)

Chair personsO. Adams (Dusseldorf/DE)E. Avota (Wurzburg/DE)R. Bartenschlager (Heidelberg/DE)M. Beer (Greifswald – Isle of Riems/DE)A. Berger (Frankfurt a. M./DE)S. Boulant (Heidelberg/DE)M. Brinkmann (Braunschweig/DE)L. Dölken (Wurzburg/DE)J. F. Drexler (Berlin/DE)A. Ehrhardt (Witten/DE)A. Ensser (Erlangen/DE)F. Erhard (Wurzburg/DE)T. Gerlach (Marburg/DE)

G. Gerold (Hanover/DE)C. Goffinet (Hanover/DE)T. Gramberg (Erlangen/DE)A. Grundhoff (Hamburg/DE)A. Hahn (Göttingen/DE)A. Halenius (Freiburg/DE)T. Harder (Greifswald – Isle of Riems/DE)A. Heim (Hanover/DE)H. Hengel (Freiburg/DE)E. Herker (Hamburg/DE)S. Junglen (Berlin/DE)B. Kaufer (Berlin/DE)O. Keppler (Munich/DE)F. Kirchhoff (Ulm/DE)F. Kreppel (Witten/DE)A. Krumbholz (Kiel/DE)N. Lemmermann (Mainz/DE)K. Le-Trilling (Essen/DE)P.-Y. Lozach (Heidelberg/DE)M. Marz (Jena/DE)M. Muhlebach (Langen/DE)S. Niendorf (Berlin/DE)A. Pichlmair (Martinsried/DE)C. Prifert (Wurzburg/DE)A. Ruggieri (Heidelberg/DE)D. Sauter (Ulm/DE)M. Schelhaas (Munster/DE)S. Schneider-Schaulies (Wurzburg/DE)S. Schreiner (Munich/DE)S. Stanelle-Bertram (Hamburg/DE)E. Steinmann (Hanover/DE)S. Stertz (Zurich/CH)K. Stiasny (Vienna/AT)T. Strecker (Marburg/DE)K. Sutter (Essen/DE)M. Tenbusch (Erlangen/DE)C. Uetrecht (Hamburg/DE)V. von Messling (Langen/DE)A. Volz (Munich/DE)J. von Einem (Ulm/DE)B. Walch-Ruckheim (Homburg/DE)

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PROGRAMME OVERVIEW • WEDNESDAY, 14 MARCH

Track I – The virus Track II – The host Track III – The clinical view

Lecture hall 1 Lecture hall 2 Lecture hall 312.30–13.00Opening ceremony

13.00–14.30

14.30–15.15

19.00–21.30

Virus receptors and entry / Innate immunity 1+2 / Diagnostic methods and toolsViral replication strategies 1+2 / Evolution of viruses – viruses in evolutionEmerging viruses and zoonosis

Workshop 3Diagnostic methods and tools

Coffee break within the industrial exhibition

Workshop 4Viral replication strategies 1 (DNA virus)

Workshop 5Innate immunity 2

Workshop 6Evolution of viruses – viruses in evolution

17.30–19.00

Poster session 1

Get‐Together within the industrial exhibition

Plenary session 1Structural and functional virology


Workshop 1Virus receptors and entry

Workshop 2Innate immunity 1

15.15–16.45

16.45–17.30

19.00–21.30

S. 14

S. 14

S. 15 S. 16 S. 17

S. 18 S. 19 S. 20

S. 46

S. 115

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Lecture hall 1 Lecture hall 2 Lecture hall 3

10.45–12.15

17.30–18.45

19.00–20.00

Laudationes and presentations for the Loeffler Frosch Award and Medal

GfV General Assembly

Adaptive immunity 1+2 / Viral pathogenesis and persistence / Virus vectors and gene therapyBioinformatics in virology / Intracellular transport and traffickingStructure, assembly and egress / Viral transformation and oncogenesisAntiviral therapy and resistance / Novel experimental systems and tools in virology

15.30–17.30Poster session 2

Workshop 10Viral pathogenesis and persistence

Workshop 11Adaptive immunity 2

Workshop 12Viral vectors and gene therapy

15.30–17.30Coffee break within the industrial exhibition


Plenary session 2 Systems virology

12.15–14.00Lunch break within the industrial exhibition

14.00–15.30

08.30–10.00Workshop 7Viral replication strategies 2 (RNA virus)

Workshop 8Adaptive immunity 1

Workshop 9Emerging viruses and zoonosis

10.00–10.45S. 22 S. 22 S. 23

S. 24

S. 25 S. 26 S. 27

S. 69

S. 28

S. 28

PROGRAMME OVERVIEW • THURSDAY, 15 MARCH

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PROGRAMME OVERVIEW • FRIDAY, 16 MARCH


Lecture hall 1 Lecture hall 2 Lecture hall 3

10.15–11.45

15.15–16.30

Poster Session 3Host cell factors and viral modulation 1+2 / Vaccines / Epidemiology and public healthClinical virology

Social evening

Plenary session 4 Promoting young scientists

Workshop 19Bioinformatics in virology

Workshop 20Intracellular transport and trafficking

Workshop 21Epidemiology and public health

18.00–19.30

16.30–18.00

20.00–01.00

Workshop 14Viral transformation and oncogenesis

Workshop 13Structure, assembly and egress

13.15–14.45


11.45–13.15Lunch break within the industrial exhibition

Workshop 15Antiviral therapy and resistance

Plenary session 3Virus immunology and restriction

Workshop 16Novel experimental systems and tools in virology

Workshop 17Host cell factors and viral modulation 1

08.30–10.00

Workshop 18Vaccines


S. 30 S. 31 S. 32

S. 33

S. 33 S. 34 S. 35

S. 36

S. 36 S. 37 S. 38

S. 90

S. 115

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PROGRAMME OVERVIEW • SATURDAY, 17 MARCH

Track I – The virus Track II – The host

Lecture hall 1 Lecture hall 2

10.45–12.15

12.15–12.45

Workshop 22Host cell factors and viral modulation 2 (RNA viruses)

Workshop 23Clinical virology

Plenary session 5Next‐Generation Sequencing in clinical virology

Poster prizes and farewell

09.00–10.30


S. 40 S. 41

S. 42

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SCIENTIFIC PROGRAMME • WEDNESDAY, 14 MARCH

12.30–13.00 Opening ceremonyRoom Lecture hall 1

Musical interlude “TICO TICO” Duo Dixie Heartbreakers

Welcome note by the president of the Society for Virology H. Hengel (Freiburg/DE)

Welcome note by the conference chair L. Dölken (Wurzburg/DE)

Welcome note by the president of the Julius-Maximilians-Universität A. Forchel (Wurzburg/DE)

Musical interlude “Cantina Band” Duo Dixie Heartbreakers

13.00–14.30 Plenary session 1 – Structural and functional virologyRoom Lecture hall 1Chairs S. Schneider-Schaulies (Wurzburg/DE), R. Bartenschlager (Heidelberg/DE)

13.00 Integrated structural cell biology of virus-host interactionsIL 01 K. Grunewald (Hamburg/DE)

13.30 Tools to study roles of lipids in virus-host interactionsIL 02 B. Brugger (Heidelberg/DE)

14.00 Protein complexes as virus entry ports – lessons learned from Hepatitis CIL 03 virus G. Gerold (Hanover/DE)

14.30–15.15 Coffee break within the industrial exhibition

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15.15–16.45 Workshop 1 – Viral receptors and entryRoom Lecture hall 1Chairs T. Gerlach (Marburg/DE), K. Stiasny (Vienna/AT)

15.15 Cryo-electron microscopy structures of MERS-CoV and SARS-CoV spikeOP 01 glycoproteins reveal the dynamic receptor binding domains Y. Shi (Beijing/CN)

15.30 CRISPR-forward screening approach identified host cell factors required OP 02 for bat influenza A-like virus (bat IAV) cell entry T. Thamamongood (Freiburg/DE), U. Karakus (Zurich/CH), K. Ciminski R. Wei (Freiburg/DE), G. Zimmer (Mittelhäusern/CH) M. Beer (Greifswald – Isle of Riems/DE), A. Garcia-Sastre (New York, NY/US) S. Stertz (Zurich/CH), M. Schwemmle (Freiburg/DE)

15.45 The rhesus monkey Rhadino virus interacts through glycoprotein H withOP 03 plexin domain-containing protein 2, a novel cellular receptor A. Großkopf (Göttingen/DE), A. Ensser (Erlangen/DE) S. Schlagowski (Göttingen/DE), R. Desrosiers (Miami, FL/US) A. Hahn (Göttingen/DE)

16.00 Interactions of the “stem element” in the Flavi virus fusion protein are OP 04 essential for post-fusion structure formation I. Medits (Vienna/AT), A. Rouvinski, M.-C. Vaney, F. Rey (Paris/FR) F. X. Heinz, K. Stiasny (Vienna/AT)

16.15 Measles virus infected dendritic cell migration in a 3D in vitro human OP 05 airway test system S. Derakhshani, M. Steinke, S. Schneider-Schaulies (Wurzburg/DE)

16.30 ADAM17 is required for formation of the HPV16 entry platformOP 06 S. Mikuličić, F. Boukhallouk, E. Wustenhagen (Mainz/DE), J. Finke Y. Homsi (Bonn/DE), K. Reiß (Kiel/DE), T. Lang (Bonn/DE) L. Florin (Mainz/DE)

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15.15–16.45 Workshop 2 – Innate immunity 1Room Lecture hall 2Chairs M. M. Brinkmann (Braunschweig/DE), V. T. K. Le-Trilling (Essen/DE)

15.15 GBP2 and GBP5 reduce HIV-1 virion infectivity by targeting the cellularOP 07 protease furin E. Reith, D. Hotter, F. Zech, F. Kirchhoff, D. Sauter (Ulm/DE)

15.30 Membranous fingerprinting of HIV-1 infected primary CD4+ T cells revealsOP 08 virus-mediated dysregulation of a putative NK cell receptor S. Dehn (Tubingen/DE), H. Koppensteiner, S. Bolduan (Munich/DE) M. C. Codrea, K. Boldt (Tubingen/DE), C. Russo, T. Bauer (Munich/DE) M. Ueffing, S. Nahnsen (Tubingen/DE), R. Draenert (Munich/DE) M. Schindler (Tubingen, Munich/DE)

15.45 SAMHD1 inhibits endogenous retroelements in a phosphodependentOP 09 manner A. Herrmann, S. Wittmann (Erlangen/DE), C. Shepard B. Kim (Atlanta, GA/US), D. Thomas, N. Ferreirós (Frankfurt a. M./DE) T. Gramberg (Erlangen/DE)

16.00 The chromatin remodeling factor SPOC1 restricts human Cytomegalo virusOP 10 (HCMV) by recruitment of the co-repressor protein KAP-1 to the viral immediate early promoter A. Reichel (Erlangen/DE), M. Scherer (Ulm/DE), A.-C. Stilp, N. Reuter S. Lukassen (Erlangen/DE), S. Schreiner (Munich/DE) A. Winterpacht (Erlangen/DE), T. Stamminger (Ulm/DE)

16.15 Bivalent role of PML isoforms during HAdV productive infectionOP 11 J. Mai, M. Stubbe, P. Groitl, S. Schreiner (Munich/DE)

16.30 Deciphering of the human interferon-regulated proteome by massOP 12 spectrometry-based quantitative analysis reveals extent and dynamics of protein induction and repression D. A. Megger, J. Philipp (Bochum/DE), V. T. K. Le-Trilling (Essen/DE) B. Sitek (Bochum/DE), M. Trilling (Essen/DE)

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15.15–16.45 Workshop 3 – Diagnostic methods and toolsRoom Lecture hall 3Chairs S. Niendorf (Berlin/DE), C. Prifert (Wurzburg/DE)

15.15 Sensitive and specific detection of Crimean Congo Hemorrhagic Fever OP 13 Virus (CCHFV) – specific IgM and IgG antibodies in human sera using Recombinant CCHFV nucleoprotein as antigen in µ-capture and IgG immune complex (IC) ELISA tests P. Emmerich (Hamburg, Rostock/DE), A. Mika, R. von Possel, A. Rackow Y. Liu, H. Schmitz, S. Gunther (Hamburg/DE), K. Sherifi, B. Halili, X. Jakupi L. Berisha, S. Ahmeti (Prishtina/KZ), C. Deschermeier (Hamburg/DE)

15.30 Development of two novel highly specific and sensitive ZIKV immuneOP 14 complex binding IgM and IgG ELISA C. Ehmen (Hamburg/DE), R. Medialdea (Liverpool/GB), D. Brown, A. Bispo P. Sequeira, R. Nogueira (Rio de Janeiro/BR), J. Schmidt-Chanasit A. Rackow, A.-M. Mallmann, J. Sievertsen, C. Deschermeier A. Mika (Hamburg/DE)

15.45 Towards a syndrome-based multiplex test for the specific diagnosis ofOP 15 Flavi virus infection E. Mora-Cárdenas, S. Rizzo, D. Sblattero, A. Marcello (Trieste/IT)

16.00 Clinical validation of a novel ELISpot-based in vitro diagnostic assay toOP 16 monitor CMV-specific cell-mediated immunity in immunocompromised transplant recipients B. Banas (Regensburg/DE), E. Wagner (Mainz/DE), D. Steubl (Munich/DE) D. Teschner (Mainz/DE), L. Renders (Munich/DE), D. Chittka M. Banas (Regensburg/DE), T. Wekerle (Vienna/AT) M. Koch (Hamburg-Eppendorf/DE), O. Witzke, M. Lindemann (Essen/DE) A. Muehlfeld (Aachen/DE), C. Sommerer (Heidelberg/DE) A. Habicht (Munich/DE), C. Hugo (Dresden/DE), T. Huenig (Wurzburg/DE) C. Wolschke, D. Janson (Hamburg-Eppendorf/DE), K. Schaefer-Eckart J. Gaertner (Nurnberg/DE), S. Mielke, M. Schreder (Wurzburg/DE) G. Kobbe, M. Kondakci (Dusseldorf/DE), S. Klein, D. Heidenreich S. Kreil (Mannheim/DE), I. Hilgendorf, M. von Lilienfeld-Toal (Jena/DE) M. Verbeek, S. Grass (Munich/DE), M. Ditschkowski, T. Gromke (Essen/DE) T. Schmidt, A. Rascle, S. Barabas (Regensburg/DE) B. Kraemer (Mannheim/DE), L. Deml, R. Wagner (Regensburg/DE) B. Krueger (Mannheim/DE), D. Wolff (Regensburg/DE)

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16.15 FluType – Development of a peptide based finetyping platform forOP 17 influenza A viruses S. Sänger (Berlin/DE), H. Memczak, M. Hovestädt, B. Ay, F. Bier (Potsdam/DE) T. Wolff (Berlin/DE)

16.30 A TCID50 assay to determine the serum infectivity of Hepatitis delta virusOP 18 containing serum – an in vitro assay to define infectious units and test for resistance K. Schöneweis, M. Bock, F. Lempp (Heidelberg/DE), B. Bremer (Hanover/DE) A. Alexandrov (Bad Homburg/DE), H. Wedemeyer (Hanover/DE) S. Urban (Heidelberg/DE)


17.30–19.00 Workshop 4 – Viral replication strategies 1 (DNA virus)Room Lecture hall 1Chairs B. Kaufer (Berlin/DE), S. Schreiner (Munich/DE)

17.30 Comprehensive reannotation of the HSV-1 transcriptome and translatomeOP 19 A. Whisnant, T. Hennig, C. Jurges, S. Riegler, C. Ector, F. Erhard L. Dölken (Wurzburg/DE)

17.45 Glucosamine modulates HBV replication through inhibiting mTOR OP 20 signaling and blocking autophagic degradation Y. Lin, X. Wang, T. Kemper, S. Liu, M. Lu (Essen/DE)

18.00 Covalent SUMO attachment to HAdV E2A by host-cell cascades is beneficialOP 21 for productive virus replication M. Stubbe, J. Mai, H. C. Stubbe (Munich/DE) J. Berscheminski (Hamburg/DE), M. Karimi, S. Hofmann, E. Weber K. Hadian (Munich/DE), R. T. Hay (Dundee/GB), P. Groitl (Munich/DE) T. Dobner (Hamburg/DE), S. Schreiner (Munich/DE)

18.15 Cyclin H associates with both CDK7 and viral CDK ortholog pUL97 in aOP 22 functionally important manner and underlies specific modifications in Cytomegalo virus-infected cells L. Keller, M. Steingruber (Erlangen/DE), S. Ferre, Y. Couté (Grenoble/FR) H. Sticht, F. Hahn, M. Marschall (Erlangen/DE)

18.30 Exchange of MCMV-M32 with HCMV-pUL32 is not sufficient to confer cellOP 23 cycle dependency to MCMV Q. V. Phan, B. Vetter, C. Hagemeier, L. Wiebusch (Berlin/DE)

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18.30 Exchange of MCMV-M32 with HCMV-pUL32 is not sufficient to confer cellOP 23 cycle dependency to MCMV Q. V. Phan, B. Vetter, C. Hagemeier, L. Wiebusch (Berlin/DE)

18.45 The mouse Cytomegalo virus-encoded interferon antagonist pM27 OP 24 interacts with the viral tegument protein pM32 M. Eilbrecht, V. T. K. Le-Trilling, S. Borkowsky (Essen/DE) D. A. Megger (Bochum/DE), M. Hasenberg (Essen/DE), Z. Ruzsics H. Hengel (Freiburg/DE), M. Trilling (Essen/DE)

17.30–19.00 Workshop 5 – Innate immunity 2Room Lecture hall 2Chairs D. Sauter (Ulm/DE), T. Gramberg (Erlangen/DE)

17.30 Induction and suppression of antiviral RNAi immunity by human virusOP 25 Q. Yang, X. Zhou (Hubei/CN)

17.45 Whole genome CRISPR/Cas9-KO Screen reveals PKR as the key player inOP 26 rabies virus cytotoxicity A. Ghanem, M. F. Eizinger, A. Hennrich, V. Pfaffinger K.-K. Conzelmann (Munich/DE)

18.00 Sandfly fever Sicilian virus virulence factor NSs specifically targets IRF3 toOP 27 inhibit type I interferon induction J. D. Wuerth (Giessen/DE), M. Habjan (Martinsried/DE) A. Pichlmair (Munich/DE), G. Superti-Furga (Vienna/AT) F. Weber (Giessen/DE)

18.15 Antiviral inflammasome responses visualised with a novel virus-encodedOP 28 biosensor M. H. Christensen, F. I. Schmidt (Bonn/DE)

18.30 The multifaceted m152 protein selectively modulates STING-dependentOP 29 signaling to enhance MCMV replication M. Stempel, B. Chan (Braunschweig/DE), V. J. Lisnić (Rijeka/HR) J. Hartung, N. Fullbrunn (Braunschweig/DE), S. R. Paludan (Aarhus/DK) S. Jonjić (Rijeka/HR), N. Lemmermann (Mainz/DE) M. M. Brinkmann (Braunschweig/DE)

18.45 Spindle-E acts antiviral against Alpha viruses in mosquito cellsOP 30 M. Varjak, I. Dietrich, S. Vattipally, B. E. Till (Glasgow/GB), A. Merits (Tartu/EE) A. Kohl (Glasgow/GB), E. Schnettler (Glasgow/GB; Hamburg/DE)

20


17.30–19.00 Workshop 6 – Evolution of viruses – viruses in evolutionRoom Lecture hall 3Chairs S. Stanelle-Bertram (Hamburg/DE), T. Harder (Greifswald – Isle of Riems/DE)

17.30 Evolution of attachment glycoprotein (G) gene in human respiratoryOP 31 syncytial virus from children with bronchiolitis in Beijing 2006–2016 T. Zhang, J. Deng, Y. Qian, R. Zhu, Y. Sun, F. Wang, R. Tian, L. Zhao (Beijing/CN)

17.45 Bruges virus, a novel Hanta virus of the European mole, is involved inOP 32 frequent Nova virus coinfections L. Laenen, V. Vergote, L. E. Kafetzopoulou, T. Wawina Bokalinga (Leuven/BE) D. Vassou (Heraklion/GR), J. A. Cook (Albuquerque, NM/US) J.-P. Hugot (Paris/FR), W. Deboutte (Leuven/BE), P. T. Witkowski P. Köppen-Rung, D. H. Kruger (Berlin/DE), M. Lickova (Bratislava/SK) A. Stang (Bochum/DE), L. Strieskova, T. Szemes (Bratislava/SK), J. Markowski J. Hejduk (Lodz/PL), D. Kafetzopoulos (Heraklion/GR) M. Van Ranst (Leuven/BE), R. Yanagihara (Honolulu, HI/US) B. Klempa (Berlin/DE; Bratislava/SK), P. Maes (Leuven/BE)

18.00 Story of arboviral lifecycle – acquisition mechanism from hosts to OP 33 mosquitoes G. Cheng (Beijing/CN)

18.15 The impact of NS segment reassortment on growth kinetics and OP 34 pathogenicity of the 2009 pandemic H1N1 influenza A virus A. Mostafa (Giessen/DE; Dokki, Cairo/EG), H. Petersen (Hanover/DE) M. A. Tantawy (Hanover/DE; Cairo/EG) A. A. Iqbal (Hanover, Braunschweig/DE) D. Hoffmann (Greifswald – Isle of Riems/DE), A. Tallam (Hanover/DE) B. Selvakumar (Giessen/DE), F. Pessler (Hanover, Braunschweig/DE) M. Beer (Greifswald – Isle of Riems/DE), S. Rautenschlein (Hanover/DE) S. Pleschka (Giessen/DE)

21


18.30 A novel Hepatitis B virus species discovered in capuchin monkeys sheds OP 35 new light on the evolution of primate Hepadna viruses A. Rasche (Berlin, Bonn/DE) B. F. de Carvalho Dominguez Souza (Bonn/DE; Salvador/BR) A. König (Giessen/DE), I. de Oliveira Carneiro (Salvador/BR) N. Stephan (Giessen/DE), V. M. Corman (Berlin, Bonn/DE) P. L. Roppert, N. Goldmann, S. F. Muller (Giessen/DE), C. Völker (Bonn/DE) A. J. Souza de Souza, M. Soares Gomes-Gouvêa (São Paulo/BR) A. Moreira-Soto (Bonn, Berlin/DE), A. Stöcker (Salvador/BR) M. Nassal (Freiburg/DE), C. R. Franke (Salvador/BR) J. R. Rebello PInho (São Paulo/BR), M. d. C. Pereira Soares (Belem/BR) J. Geyer (Giessen/DE), P. Lemey (Leuven/BE), C. Drosten (Berlin, Bonn/DE) E. Martins Netto (Salvador/BR), D. Glebe (Giessen/DE) J. F. Drexler (Berlin, Bonn/DE)

18.45 Recombination, degradation and remobilisation of endogenous OP 36 retroviruses during the earliest stages of a germ line invasion U. Löber (Berlin/DE), M. Hobbs (Sydney/AU), G. McKewen (Berlin/DE) K. Tsangaras (Nicosia/CY), K. Jones (St. Lucia/AU) D. Alquezar-Planas (Sydney/AU), Y. Ishida (Urbana, IL/US) J. Mayer (Homburg/DE), J. Meers (St. Lucia/AU), A. Dayaram C. Quadenau (Berlin/DE), W. Chen (Berlin/DE; Shenzhen/CN) R. Johnson (Sydney/AU), P. Timms (Sippy Downs/AU) P. Young (St. Lucia/AU), A. Roca (Urbana, IL/US) A. Greenwood (Berlin/DE)

19.00–21.30 Poster session 1Room 1, 3+4, 5, 6+7, 10+11, 13 Diagnostic methods and tools, Emerging viruses and zoonosis, Evolution of viruses – viruses in evolution, Innate immunity 1+2

(Please refer to page 46 for the poster floor plan and the poster session overview.)

19.00–21.30 Get-Together within the industrial exhibition (please refer to page 115)

22

SCIENTIFIC PROGRAMME • THURSDAY, 15 MARCH

08.30–10.00 Workshop 7 – Viral replication strategies 2 (RNA virus)Room Lecture hall 1Chairs A. Pichlmair (Martinsried/DE), T. Strecker (Marburg/DE)

08.30 Insights into the cap-snatching mechanism of Arena- and Bunya virusesOP 37 Y. Fernandez Garcia, M. Rosenthal, S. Gunther, S. Reindl (Hamburg/DE)

08.45 Structural and functional insights into the bovine Hepaci virus internalOP 38 ribosome entry site A. L. Baron, P. Becher, C. Bächlein (Hanover/DE), A. Schöniger (Leipzig/DE)

09.00 Rearrangement of a viral riboswitch by the cellular RNA-binding proteinOP 39 complex NF90-NF45 enables the initiation of RNA replication of Hepatitis C virus T. Schmidt, S. Friedrich, R. P. Golbik, S.-E. Behrens (Halle a. d. S./DE)

09.15 Characterisation of a conserved RNA pseudoknot in a putative molecularOP 40 switch domain of the 3’-UTR of Alphacorona viruses R. Madhugiri, N. Karl, N. Goldmann (Giessen/DE), M. Marz (Jena/DE) J. Ziebuhr (Giessen/DE)

09.30 Use of highly multiplexed single-molecule magnetic tweezers to OP 41 characterise drug incorporation by Polio virus RNA-dependent RNA polymerases D. Dulin (Erlangen/DE)

09.45 Experimental determination of the BVDV NS2 membrane topologyOP 42 N. Tautz, T. Walther, J. Fellenberg (Lubeck/DE)

08.30–10.00 Workshop 8 – Adaptive immunity 1Room Lecture hall 2Chairs C. Goffinet (Hanover/DE), M. Muhlebach (Langen/DE)

08.30 Hepatitis B virus escapes non-canonical CD8 T cell effector functionOP 43 S. Kurz, K. Steiger, U. Protzer, P. Knolle, D. Wohlleber (Munich/DE)

08.45 Structural dynamics of Flavi virus particles influences antibody OP 44 interactions and virus neutralisation G. Tsouchnikas, D. Haslwanter, K. Stiasny, F. X. Heinz (Vienna/AT)

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09.00 Role of adjuvants in immune response dynamics after influenza OP 45 vaccination C. Parra-Rojas (Frankfurt a. M./DE), V. von Messling (Langen/DE) E. A. Hernandez-Vargas (Frankfurt a. M./DE)

09.15 IFN-λ acts as mucosal adjuvant strongly promoting TSLP-mediated IgG1OP 46 and IgA antibody responses L. Ye, D. Schnepf, J. Becker, K. Ebert, Y. Tanriver (Freiburg/DE) V. Bernasconi (Gothenburg/SE), H. H. Gad, R. Hartmann (Aarhus/DK) N. Lycke (Gothenburg/SE), P. Stäheli (Freiburg/DE)

09.30 VSV-GP as vaccine vector for RSVOP 47 S. Wilmschen, S. Schneider (Innsbruck/AT), L. Bayer, T. Grunwald (Leipzig/DE) D. von Laer, J. Kimpel (Innsbruck/AT)

09.45 Targeting HIV’s reservoir – cytolytic CD4 T cells with follicular homingOP 48 properties in chronic HIV infection E. Richter (Essen/DE), J. Eberhard (Hamburg/DE), M. Korencak B. Schultz, S. Esser (Essen/DE), J. Schulze zur Wiesch (Hamburg/DE) H. Streeck (Essen/DE; Rockville, MD/US)

08.30–10.00 Workshop 9 – Emerging viruses and zoonosisRoom Lecture hall 3Chairs M. Beer (Greifswald – Isle of Riems/DE), S. Junglen (Berlin/DE)

08.30 APOBEC3H protein forms a barrier for cross-species transmission of SIVs ofOP 49 chimpanzee to humans Z. Zhang, Q. Gu (Dusseldorf/DE), M. d. M. Montero (Barcelona/ES) I. Bravo (Montpellier/FR), T. M. Bonet (Barcelona/ES), D. Häussinger C. Munk (Dusseldorf/DE)

08.45 Rift valley fever virus virulence factor NSs disrupts the nuclear pore complexOP 50 S. Lau (Giessen/DE), M. Habjan (Martinsried, Munich/DE) G. Superti-Furga (Vienna/AT), A. Pichlmair (Martinsried, Munich/DE) F. Weber (Giessen/DE)

09.00 Water – a potential vector for Herpes virusOP 51 A. Dayaram, M. Franz, A. Schattschneider, A. Damiani, S. Bischofberger S. Soilemetzidou, P. Seeber (Berlin/DE) C. Walzer (Vienna/AT; New York NY/US), N. Osterrieder A. Greenwood (Berlin/DE)

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09.15 A genome-wide siRNA screen identifies a druggable host pathway asOP 52 essential for the life cycle of Ebola virus S. Martin (Bethesda, MD/US), A. Chiramel (Hamilton, MT/US) M. L. Schmidt (Greifswald – Isle of Riems/DE), Y.-C. Chen N. Whitt (Bethesda, MD/US), A. Watt, E. Dunham, K. Shifflett S. Traeger (Hamilton, MT/US), A. Leske (Greifswald – Isle of Riems/DE) E. Buehler (Bethesda, MD/US), C. Martellaro (Hamilton, MT/US) J. Brandt, L. Wendt (Greifswald – Isle of Riems/DE) S. Best (Hamilton, MT/US), J. Stech, S. Finke A. Römer-Oberdörfer (Greifswald – Isle of Riems/DE) A. Groseth (Hamilton, MT/US; Greifswald – Isle of Riems/DE) H. Feldmann (Hamilton, MT/US) T. Hoenen (Greifswald – Isle of Riems/DE; Hamilton, MT/US) 09.30 M1 mRNA splicing influences Influenza A virus host specificityOP 53 B. Bogdanow, K. Eichelbaum, A. Sadewasser, G. Heins, I. Husic, K. Paki X. Wang, J. Hou, B. Vetter, W. Chen, L. Wiebusch, T. Wolff M. Selbach (Berlin/DE)

09.45 Assessment of the zoonotic potential of the bat influenza A-like virusOP 54 HL18NL11 K. Ciminski, W. Ran (Freiburg/DE), M. Gorka (Greifswald – Isle of Riems/DE) E. Hassan (Freiburg/DE), A. Pohlmann D. Hoffmann (Greifswald – Isle of Riems/DE), W. Ma (Manhattan, NY/US) T. Schountz (Fort Collins, CO/US), M. Beer (Greifswald – Isle of Riems/DE) M. Schwemmle (Freiburg/DE)


10.45–12.15 Plenary session 2 – Systems virologyRoom Lecture hall 1Chairs L. Dölken (Wurzburg/DE), A. Grundhoff (Hamburg/DE)

10.45 Genetic and proteomic approaches to viral evasionIL 04 P. Lehner (Cambridge/GB)

11.15 Diversity and evolution of RNA virusIL 05 Y.-Z. Zhang (Beijing/CN)

11.45 Innate immune DNA sensing in health and diseaseIL 06 A. Ablasser (Lausanne/CH)

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© 50697270 l sebileiste/72696972 l Artalis-Kartographie/69654140 l Michael l Fotolia.com

DZIF ACADEMY2018

6th TRANSLATIONAL DZIF-SCHOOL7–9 NOVEMBER 2018 LÜBECK ATLANTIC HOTEL

www.dzif-autumn-school.de

12.15–12.25 Award ceremony of the PhD prize

12.15–14.00 Lunch break within the industrial exhibition

14.00–15.30 Workshop 10 – Viral pathogenesis and persistenceRoom Lecture hall 1Chairs N. Lemmermann (Mainz/DE), K. Sutter (Essen/DE)

14.00 Kaposi’s sarcoma-associated Herpes virus – towards better understandingOP 55 of its latency and pathogenesis K. Lan (Hubei/CN)

14.15 Kaposi’s sarcoma-associated Herpes virus vIRF2 protein utilises an IFNOP 56 dependent pathway to regulate viral latency S. Koch, M. Damas, E. Hage, A. Dhingra J. Ruckert (Braunschweig, Hanover/DE), A. Gallo, W. Brune (Hamburg/DE) W. Tegge, S.-K. Hotop (Braunschweig/DE) T. Schulz (Hanover, Braunschweig/DE)

26


14.30 Human macrophages escape inhibition of major histocompatibilityOP 57 complex-dependent antigen presentation by Cytomegalo virus and drive proliferation and activation of memory CD4 and CD8 T cells G. Frascaroli (Hamburg, Ulm/DE), C. Bayer (Ulm/DE), S. Varani (Bologna/IT) C. Setz, J. van der Merwe (Ulm/DE), W. Brune (Hamburg/DE) T. Mertens (Ulm/DE)

14.45 Retrovirus seeding into the B cell follicle reservoir in the absence of OP 58 CD8+ T cell pressure S. Windmann, C. Hrycak, N. Bongard, L. Otto, J. Bezgovsek W. Bayer (Essen/DE)

15.00 The role of infection and depletion of lymphocyte subsets in the OP 59 pathogenesis of measles-induced immune suppression B. M. Laksono, R. de Vries, J. Verburgh, E. Visser, A. de Jong P. Fraaij (Rotterdam/NL), W. Ruijs (Bilthoven/NL), A. Osterhaus M. Koopmans, M. van Zelm, R. de Swart (Rotterdam/NL)

15.15 Interaction of the merkel cell Polyoma virus LT-Antigen with host cellOP 60 chromatin J. Theiss, M. Czech-Sioli, M. Spohn, A. Grundhoff, N. Fischer (Hamburg/DE)

14.00–15.30 Workshop 11 – Adaptive immunity 2Room Lecture hall 2Chairs A. Halenius (Freiburg/DE), A. Volz (Munich/DE)

14.00 Impact of Hepatitis B virus sequence diversity on CD8+ T cell responseOP 61 T. Schwarz (Dusseldorf/DE), H. Kefalakes, F. Heinemann (Essen/DE) A. Kraft (Hanover/DE), A. Walker, V. Keitel-Anselmino (Dusseldorf/DE) D. Hoffmann (Essen/DE), J. Timm (Dusseldorf/DE)

14.15 Combination therapy with anti-PD-L1 antibody and depletion of OP 62 regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology M. Drabczyk-Pluta, E. Pastille, N. Honke, T. Werner, A. M. Westendorf K. Lang, U. Dittmer, G. Zelinskyy (Essen/DE)

14.30 Structural basis for Orthobunya virus neutralisationOP 63 J. Hellert (Paris/FR), A. Aebischer, K. Wernike (Greifswald – Isle of Riems/DE) P. Guardado-Calvo (Paris/FR) , M. Beer (Greifswald – Isle of Riems/DE) F. A. Rey (Paris/FR)

27


14.45 Functional and immunogenic characterisation of diverse HCV glycoproteinOP 64 E2 variants in vitro and in vivo T. Khera, P. Behrendt, D. Bankwitz, R. Brown, D. Todt M. Doepke (Hanover/DE), A. G. Khan (New Jersey, NJ/US) K. Schulze (Braunschweig/DE), J. Law, M. Logan, D. Hockman J. A. Ji-Xhin (Edmonton/CA), L. Dold (Cologne/DE), U. Spengler (Bonn/DE) A. V. Borbolla (Hanover/DE), A. W. Tarr (Hanover/DE; Nottingham/GB) E. Steinmann, M. Manns (Hanover/DE), F. Klein (Cologne/DE) C. A. Guzman (Braunschweig/DE), J. Marcotrigiano (New Jersey, NJ/US) M. Houghton (Edmonton/CA), T. Pietschmann (Hanover/DE)

15.00 Induction of neutralising and Fc-receptor activating antibody responses OP 65 against influenza virus hemagglutinin by immunisation with Adeno-associated virus (AAV)-vectors D. Demminger, S. Norley, T. Wolff (Berlin/DE)

15.15 An ex vivo functional co-culture assay for dynamic characterisation of OP 66 cytolytic immune responses against virus infected human cells B. Kasmapour, T. Kubsch, L. Cicin-Sain (Braunschweig/DE)

14.00–15.30 Workshop 12 – Viral vectors and gene therapyRoom Lecture hall 3Chairs A. Ehrhardt, F. Kreppel (Witten/DE)

14.00 Multiplex CRISPR/Cas9 gene editing of Duchenne Muscular Dystrophy OP 67 causing mutations restores dystrophin production in immortalised dystrophic myoblasts after gene delivery with a single gene deleted adenoviral vector E. Ehrke-Schulz (Witten/DE), V. Mouly (Paris/FR), R. Kley (Bochum/DE) A. Ehrhardt (Witten/DE)

14.15 Targeting HIV in astrocytes by AAV-mediated delivery of CRISPR/Cas9OP 68 R. Brack-Werner, C. Kunze (Unterschleissheim/DE), K. Börner E. Kienle (Heidelberg/DE), T. Orschmann, M. Schneider, A. Bauer M. Radivojkov-Blagojevic, M. Drukker, S. Desbordes (Unterschleissheim/DE) D. Grimm (Heidelberg/DE)

14.30 Competition between adenoviral CD8+ T cell epitopes with OP 69 transgene-derived epitopes abrogates transgene-specific CD8+ T cell responses in Adeno virus-based immunisation C. Hrycak, D. Schöne, S. Windmann (Essen/DE), D. Lapuente (Bochum/DE) U. Dittmer (Essen/DE), M. Tenbusch (Bochum/DE), W. Bayer (Essen/DE)

28


14.45 Oncolytic influenza virus infection restores immunocompetence of lung OP 70 tumor-associated alveolar macrophages D. Masemann (Munster/DE), K. Koether (Laupheim, Munster/DE) M. Kuhlencord, G. Varga, J. Roth (Munster/DE), B. D. Lichty (Hamilton/CA) U. R. Rapp (Bad Nauheim/DE), V. Wixler, S. Ludwig (Munster/DE)

15.00 Effective interaction of measles virus-derived oncolytic vaccines with OP 71 antigen-presenting cells A. Vestweber, C. Nurnberger, B. Bodmer, S. Hutzler M. Mühlebach (Langen/DE)

15.15 Tumor microenvironment modulation in recurrent glioblastoma patients OP 72 treated with oncolytic H-1 Parvo virus A. Angelova, M. Barf (Heidelberg/DE), K. Geletneky (Darmstadt/DE) A. Unterberg, J. Rommelaere (Heidelberg/DE)


15.30–17.30 Poster session 2Rooms 1+2, 4+5, 9–14 Adaptive immunity 1+2, Antiviral therapy and resistance Bioinformatics in virology, Intracellular transport and trafficking (Please refer to page 69 to take a look at the poster floor plan and the poster session overview.)

17.30–18.45 Laudationes and presentations for the Loeffler-Frosch-Award and MedalRoom Lecture hall 1

19.00–20.00 GfV General AssemblyRoom Lecture hall 1

Medical and Scientific Publishers

S. Karger AGMedical and Scientific PublishersCH–4009 Basel (Switzerland)[email protected]: +41 61 306 12 34www.karger.com KI

1811

40

Karger Journals in the field

Original Papers

105 Protection of Mice by a �-Based Therapeutic Vaccine against Cancer Associated with Human Papillomavirus Type 16Ghaemi, A. (Gorgan/Tehran); Soleimanjahi, H.; Gill, P.; Hassan, Z.M.; Razeghi, S.; Fazeli, M.; Razavinikoo, S.M.H. (Tehran)

113 Characterization of a Late Gene, ORF134, from Bombyx mori NucleopolyhedrovirusLin, F. (Zhenjiang/Zhejiang); Chen, K.; Xia, H.; Yao, Q.; Gao, L.; Chen, H. (Zhenjiang)

122 High Conservation of Hepatitis B Virus Surface Genes during Maternal Vertical Transmission despite Active and Passive VaccinationSu, H.-X.; Zhang, Y.-H.; Zhang, Z.-G.; Li, D.; Zhang, J.-X.; Men, K.; Zhang, L.; Long, Y.; Xu, D.-Z.; Yan, Y.-P. (Xi’an)

131 Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern ChinaCui, Y.; Wang, Y.; Liu, X.; Chao, Y.; Xing, X. (Qingdao); Zhao, C. (Pittsburgh, Pa.); Liu, C.; Luo, B. (Qingdao)

139 Evidence of Hepatitis E Virus Exposure among Seronegative Healthy Residents of an Endemic AreaHusain, M.M.; Srivastava, R. (Lucknow); Akondy, R. (Atlanta, Ga.); Aggarwal, R. (Lucknow); Jameel, S. (New Delhi); Naik, S. (Lucknow)

156 Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type 2 Capsid ProteinGuo, L.; Lu, Y.; Huang, L.; Wei, Y.; Liu, C. (Harbin)

164 Epidemiological and Clinical Features of 308 Hospitalized Patients with Novel 2009 Influenza A (H1N1) Virus Infection in China during the First Pandemic WaveZhang, G. (Wuhan/Shenzhen); Xia, Z.; Liu, Y. (Shenzhen); Li, X. (Beijing); Tan, X. (Guangzhou); Tian, Y.; Liang, L. (Beijing); Nie, G. (Shenzhen); Zhou, B. (Wuhan/Shenzhen)

Short Communications

146 HPV-58 Molecular Variants Exhibit Different Transcriptional ActivityRaiol, T.; de Amorim, R.M.S. (Brasília); Galante, P. (São Paulo); Martins, C.R.F. (Brasília); Villa, L.L.; Sichero, L. (São Paulo)

151 Epidemiology and Seroprevalence of Human Immunodeficiency Virus Type 2Kashyap, B.; Gautam, H.; Bhalla, P. (New Delhi)

Case Report

144 The First Crimean-Congo Hemorrhagic Fever Case in the Winter Season from TurkeyKöksal, I.; Yilmaz, G.; Iskender, S.; Arslan, M.; Yavuz, I.; Aksoy, F. (Trabzon); Vatansever, Z. (Kars)

Su, H.-X.; Zhang, Y.-H.; Zhang, Z.-G.; Li, D.; Zhang, J.-X.; Men, K.; Zhang, L.; Long, Y.; Xu, D.-Z.; Yan, Y.-P. (Xi’an)

Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in

Cui, Y.; Wang, Y.; Liu, X.; Chao, Y.; Xing, X. (Qingdao); Zhao, C. (Pittsburgh, Pa.); Liu, C.; Luo, B. (Qingdao)

Evidence of Hepatitis E Virus Exposure among Seronegative Healthy Residents of an Endemic AreaHusain, M.M.; Srivastava, R. (Lucknow); Akondy, R. (Atlanta, Ga.); Aggarwal, R. (Lucknow); Jameel, S.

Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type

Guo, L.; Lu, Y.; Huang, L.; Wei, Y.; Liu, C. (Harbin)

Immunodeficiency Virus Type 2

The forum for innovative research in virologyEditor-in-ChiefJ.-C. Manuguerra, Pariswww.karger.com/int

Reflecting the integration of basic and applied microbiologyEditor-in-ChiefM.H. Saier, Jr., La Jolla, CAwww.karger.com/mmb

An international forum on all aspects of antimicrobial and antitumor chemotherapyEditor-in-ChiefG. Minotti, Romewww.karger.com/che

29

GENERAL INFORMATION

Medical and Scientific Publishers

S. Karger AGMedical and Scientific PublishersCH–4009 Basel (Switzerland)[email protected]: +41 61 306 12 34www.karger.com KI

1811

40

Karger Journals in the field

Original Papers

105 Protection of Mice by a �-Based Therapeutic Vaccine against Cancer Associated with Human Papillomavirus Type 16Ghaemi, A. (Gorgan/Tehran); Soleimanjahi, H.; Gill, P.; Hassan, Z.M.; Razeghi, S.; Fazeli, M.; Razavinikoo, S.M.H. (Tehran)

113 Characterization of a Late Gene, ORF134, from Bombyx mori NucleopolyhedrovirusLin, F. (Zhenjiang/Zhejiang); Chen, K.; Xia, H.; Yao, Q.; Gao, L.; Chen, H. (Zhenjiang)

122 High Conservation of Hepatitis B Virus Surface Genes during Maternal Vertical Transmission despite Active and Passive VaccinationSu, H.-X.; Zhang, Y.-H.; Zhang, Z.-G.; Li, D.; Zhang, J.-X.; Men, K.; Zhang, L.; Long, Y.; Xu, D.-Z.; Yan, Y.-P. (Xi’an)

131 Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern ChinaCui, Y.; Wang, Y.; Liu, X.; Chao, Y.; Xing, X. (Qingdao); Zhao, C. (Pittsburgh, Pa.); Liu, C.; Luo, B. (Qingdao)

139 Evidence of Hepatitis E Virus Exposure among Seronegative Healthy Residents of an Endemic AreaHusain, M.M.; Srivastava, R. (Lucknow); Akondy, R. (Atlanta, Ga.); Aggarwal, R. (Lucknow); Jameel, S. (New Delhi); Naik, S. (Lucknow)

156 Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type 2 Capsid ProteinGuo, L.; Lu, Y.; Huang, L.; Wei, Y.; Liu, C. (Harbin)

164 Epidemiological and Clinical Features of 308 Hospitalized Patients with Novel 2009 Influenza A (H1N1) Virus Infection in China during the First Pandemic WaveZhang, G. (Wuhan/Shenzhen); Xia, Z.; Liu, Y. (Shenzhen); Li, X. (Beijing); Tan, X. (Guangzhou); Tian, Y.; Liang, L. (Beijing); Nie, G. (Shenzhen); Zhou, B. (Wuhan/Shenzhen)

Short Communications

146 HPV-58 Molecular Variants Exhibit Different Transcriptional ActivityRaiol, T.; de Amorim, R.M.S. (Brasília); Galante, P. (São Paulo); Martins, C.R.F. (Brasília); Villa, L.L.; Sichero, L. (São Paulo)

151 Epidemiology and Seroprevalence of Human Immunodeficiency Virus Type 2Kashyap, B.; Gautam, H.; Bhalla, P. (New Delhi)

Case Report

144 The First Crimean-Congo Hemorrhagic Fever Case in the Winter Season from TurkeyKöksal, I.; Yilmaz, G.; Iskender, S.; Arslan, M.; Yavuz, I.; Aksoy, F. (Trabzon); Vatansever, Z. (Kars)

Su, H.-X.; Zhang, Y.-H.; Zhang, Z.-G.; Li, D.; Zhang, J.-X.; Men, K.; Zhang, L.; Long, Y.; Xu, D.-Z.; Yan, Y.-P. (Xi’an)

Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in

Cui, Y.; Wang, Y.; Liu, X.; Chao, Y.; Xing, X. (Qingdao); Zhao, C. (Pittsburgh, Pa.); Liu, C.; Luo, B. (Qingdao)

Evidence of Hepatitis E Virus Exposure among Seronegative Healthy Residents of an Endemic AreaHusain, M.M.; Srivastava, R. (Lucknow); Akondy, R. (Atlanta, Ga.); Aggarwal, R. (Lucknow); Jameel, S.

Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type

Guo, L.; Lu, Y.; Huang, L.; Wei, Y.; Liu, C. (Harbin)

Immunodeficiency Virus Type 2

The forum for innovative research in virologyEditor-in-ChiefJ.-C. Manuguerra, Pariswww.karger.com/int

Reflecting the integration of basic and applied microbiologyEditor-in-ChiefM.H. Saier, Jr., La Jolla, CAwww.karger.com/mmb

An international forum on all aspects of antimicrobial and antitumor chemotherapyEditor-in-ChiefG. Minotti, Romewww.karger.com/che

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SCIENTIFIC PROGRAMME • FRIDAY, 16 MARCH

08.30–10.00 Workshop 13 – Structure, assembly and egressRoom Lecture hall 1Chairs C. Uetrecht (Hamburg/DE), J. von Einem (Ulm/DE)

08.30 Crystallographic and cryo-EM structures of the merkel cell Polyoma virus OP 73 capsid B. Blaum, N. Bayer (Tubingen/DE), A. Möller (Frankfurt a. M./DE) T. Stehle (Tubingen/DE)

08.45 Noro virus-like VP1 particles exhibit isolate-dependent stability profilesOP 74 R. Pogan, C. Schneider, R. Reimer (Hamburg/DE) G. Hansman (Heidelberg/DE), C. Uetrecht (Hamburg, Schenefeld/DE)

09.00 Functional domains in the Herpes virus nuclear egress complexOP 75 B. Klupp, T. Hellberg, S. Rönfeldt, K. Franzke T. C. Mettenleiter (Greifswald – Isle of Riems/DE)

09.15 Inner tegument proteins of Herpes simplex virus are sufficient for OP 76 intracellular capsid motility in neurons but not for axonal targeting A. Buch, O. Muller, L. Ivanova, K. Döhner, D. Bialy (Hanover/DE) J. B. Bosse (Hamburg/DE), A. Pohlmann, A. Binz, M. Hegemann C.-H. Nagel (Hanover/DE), M. Koltzenburg (London/GB), A. Viejo-Borbolla B. Rosenhahn, R. Bauerfeind, B. Sodeik (Hanover/DE)

09.30 The influenza A virus nucleoprotein interprets the vRNA packaging signal OP 77 to coordinate genome packaging into virions H. Bolte (Freiburg/DE), M. Rosu (Rotterdam/NL) L. Kolesnikova (Marburg/DE), M. Schwemmle (Freiburg/DE)

09.45 Unique features of a HBV preS1 deletion mutant in viral assembly, release OP 78 and carcinogenesis B. Jiang (Langen/DE), L. Kuhnhenn (Langen, Frankfurt a. M./DE) R. Martarise (Langen/DE), K.-H. Peiffer (Langen, Frankfurt a. M./DE) E. Hildt (Langen/DE)

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08.30–10.00 Workshop 14 – Viral transformation and oncogenesisRoom Lecture hall 2Chairs A. Hahn (Göttingen/DE), B. Walch-Ruckheim (Homburg/DE)

08.30 The Myb-related transcription factor MYPOP is a new restriction factor for OP 79 high-risk HPV types E. Wüstenhagen, F. Boukhallouk, I. Negwer, K. Rajalingam (Mainz/DE) F. Stubenrauch (Tubingen/DE), L. Florin (Mainz/DE)

08.45 Integration of BK Polyoma virus in micropapillary urothelial carcinoma:OP 80 A role for pathogenesis? A. Knöll, S. Bertz, R. Stöhr, M. Buettner-Herold (Erlangen/DE) E. Compérat (Paris/FR), N. Gaisa (Aachen/DE), A. Karl D. Horst (Munich/DE), B. Wullich, A. Hartmann, A. Ensser (Erlangen/DE)

09.00 UV and cutaneous Papilloma virus infection cooperate in non-melanoma OP 81 skin cancer development D. Hasche, S. Stephan, I. Braspenning-Wesch, J. Mikulec, M. Niebler H.-J. Gröne, C. Flechtenmacher (Heidelberg/DE), B. Akgul (Cologne/DE) S. E. Vinzón, F. Rösl (Heidelberg/DE)

09.15 The unique structure of the EBV LMP1-TRAF6 complex is critical for viral OP 82 cell transformation and serves as target for inhibitory molecules F. Giehler (Munich/DE), D. Weidl (Erlangen/DE), M. Ostertag (Munich/DE) T. Sommermann (Berlin/DE), K. Sterz (Munich/DE) B. Biesinger (Erlangen/DE), J. Kirchmair (Hamburg/DE) G. Popowicz (Munich/DE), A. Kieser (Munich/DE)

09.30 A novel positive feedback loop between the HTLV-1 Tax oncoprotein and OP 83 NF-κB activity in T-cells S. Millen, L. Wolf, T. Göttlicher, S. Schmitt, B. Fleckenstein A. K. Thoma-Kress (Erlangen/DE)

09.45 Expansion and impact of Th17 cells in persistent HPV infection and OP 84 cervical cancer progression B. Walch-Ruckheim, R. Stroeder, L. Theobald, Y.-J. Kim, R. M. Bohle I. Juhasz-Böss, E.-F. Solomayer, S. Smola (Homburg a. d. S./DE)

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08.30–10.00 Workshop 15 – Antiviral therapy and resistanceRoom Lecture hall 3Chairs A. Krumbholz (Kiel/DE), E. Steinmann (Hanover/DE)

08.30 Inhibition of viral E6/E7 oncogene expression and induction of senescenceOP 85 in HPV-positive cancer cells J. Braun, A. Herrmann, F. Hoppe-Seyler, K. Hoppe-Seyler (Heidelberg/DE)

08.45 The small compound inhibitor K22 displays broad antiviral activity against OP 86 different members of the Flaviviridae family and offers potential as pan-viral inhibitor S. Pfänder, O. García-Nicolás, P. v’Kovski, N. J. Vielle (Bern, Mittelhäusern/CH) R. Zust (Spiez/CH), H. Stalder, J. Portmann (Bern, Mittelhäusern/CH) G. Vieyres (Hanover/DE), M. Schweizer A. Summerfield (Bern, Mittelhäusern/CH), O. Engler (Spiez/CH) T. Pietschmann (Hanover/DE), M. A. Alves, V. Thiel (Bern, Mittelhäusern/CH)

09.00 High-content screening identifies agonists for retinoic acid receptor (RAR) OP 87 as specific HBV inhibitors L. Nußbaum, S. Nkongolo, F. Lempp (Heidelberg/DE) H. Wodrich (Bordeaux/FR), S. Urban, Y. Ni (Heidelberg/DE)

09.15 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) inhibits entry of OP 88 various enveloped viruses by interfering with viral membrane fusion S. Moeschler, S. Locher, G. Zimmer (Mittelhäusern, Bern/CH)

09.30 Inhibition of the PLCγ1 recruitment to the Kaposi’s sarcoma-associated OP 89 Herpes virus K15 protein as a novel approach to interfere with early viral lytic gene expression and pathogenesis? N. Samarina, B. Abere, J. Ruckert, G. Beauclair, S. Koch, A. Viejo-Borbolla T. Krey, T. Schulz (Hanover, Braunschweig/DE)

09.45 Effectivity of novel antiviral therapy against human Herpes Simplex Virus OP 90 (HSV) in an infection lethal challenge mouse model N. Lindner, J. Krause, J. Holm (Leipzig/DE), G. Kleymann (Bad-Salzuflen/DE) T. Grunwald (Leipzig/DE)


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10.15–11.45 Plenary session 3 – Virus immunology and restrictionRoom Lecture hall 1Chairs H. Hengel (Freiburg/DE), F. Kirchhoff (Ulm/DE)

10.15 Immune programming by CMV vectorsIL 07 K. Fruh (Portland, ME/US)

10.45 RNA turnover and DNA synthesis as targets for antiviral defenseIL 08 P. Bieniasz (New York, NY/US)

11.15 Respiratory gateway into the nucleus challenged by influenza A virusesIL 09 G. Gabriel (Hamburg/DE)

11.45–13.15 Lunch break within the industrial exhibition

13.15–14.45 Workshop 16 – Novel experimental systems and tools in virologyRoom Lecture hall 1Chairs E. Avota (Wurzburg/DE), S. Boulant (Heidelberg/DE)

13.15 Surface immobilisation of viruses elucidates early events in OP 91 clathrin-mediated endocytosis M. Fratini, T. Wiegard, C. Funaya (Heidelberg/DE), Z. Jiang (Mannheim/DE) P. Shah, J. Spatz, E. A. Cavalcanti-Adam, S. Boulant (Heidelberg/DE)

13.30 Embryonic Stem Cell (ESC)-derived neuron cultures for studying Rabies OP 92 virus transsynaptic transmission M. F. Eizinger, C. Scordel, K.-K. Conzelmann (Munich/DE)

2019 II Joint MeetingGerman Society for Immunology (DGfl)Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

10–13 September 2019 l munich

© davis l fotolia.com

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13.45 Tissue-like 3D environments to study modes of HIV-1 spreadOP 93 A. Imle, N. Schnellbächer, P. Kumberger, J. Fehr, P. Carillo-Bustamante J. Ales, C. Ritter, W. J. Godinez, K. Rohr, F. Hamprecht, F. Graw, U. Schwarz O. Fackler (Heidelberg/DE)

14.00 A novel three-dimensional cell culture method enhances antiviral drug OP 94 screening in primary human cells R. Koban, M. Neumann, A. Daugs, O. Bloch, A. Nitsche (Berlin/DE) S. Langhammer (Burgwedel/DE), H. Ellerbrok (Berlin/DE)

14.15 Dissecting the cellular pathways activated by Herpes Simplex Virus OP 95 infection using single-cell RNA sequencing E. Wyler, V. Franke (Berlin/DE), J. Menegatti (Homburg/DE), C. Kocks A. Boltengagen, N. Rajewsky, A. Akalin (Berlin/DE) F. Grässer (Homburg/DE), M. Landthaler (Berlin/DE)

14.30 Identification of highly effective small RNAs for antiviral plant protectionOP 96 J. Schuck, S. Gago-Zachert, M. Knoblich, T. Gursinsky S.-E. Behrens (Halle a. d. S./DE)

13.15–14.45 Workshop 17 – Host cell factors and viral modulation 1Room Lecture hall 2Chairs G. Gerold (Hanover/DE), P.-Y. Lozach (Heidelberg/DE)

13.15 Interaction between the LINE1 retrotransposon and the Hepatitis C virusOP 97 A. Schöbel (Hamburg/DE), G. G. Schumann (Langen/DE) E. Herker (Hamburg/DE)

13.30 Transport through the nuclear pore complex is a rate-limiting step of OP 98 HIV-1 replication in macrophages and is promoted by CPSF6 D. Bejarano, K. Peng, V. Laketa, K. Börner, L. Jost, B. Glass, M. Lusic B. Muller, H.-G. Kräusslich (Heidelberg/DE)

13.45 Tripartite motif containing 28 (TRIM28) is a PKR-dependent negative OP 99 regulator of the innate immune response in influenza A virus infected cells T. Krischuns, C. Nordhoff (Munster/DE), J. Willemsen M. Binder (Heidelberg/DE), S. Ludwig, L. Brunotte (Munster/DE)

14.00 Infection-induced activation of the unfolded protein response relieves OP 100 XBP1u-mediated repression of viral gene expression and replication F. Hinte (Hamburg/DE), E. van Anken (Milan/IT), B. Tirosh (Jerusalem/IL) W. Brune (Hamburg/DE)

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14.15 The Herpes Simplex Virus-1 (HSV-1) pUL56 mediates degradation of GOPC OP 101 to alter protein presentation at the plasma membrane T. Soh, J. Muenzner, C. Davies, V. Connor, M. Weekes, S. Graham C. Crump (Cambridge/GB)

14.30 A GXXXA motif in the transmembrane domain of the Ebola virus OP 102 glycoprotein is required for tetherin antagonism M. Gonzalez Hernandez, M. Hoffmann, C. Brinkmann (Göttingen/DE) J. Nehls (Tubingen, Munich/DE), M. Winkler (Göttingen/DE) M. Schindler (Munich, Tubingen/DE), S. Pöhlmann (Göttingen/DE)

13.15–14.45 Workshop 18 – VaccinesRoom Lecture hall 3Chairs M. Tenbusch (Erlangen/DE), V. v. Messling (Langen/DE)

13.15 Pre-existing yellow fever immunity impairs and modulates the antibody OP 103 response to tick-borne encephalitis vaccination V. Bradt, J. Jarmer, G. Tsouchnikas, I. Medits, S. Malafa (Vienna/AT) U. Karrer (Zurich, Winterthur/CH), K. Stiasny, F. X. Heinz (Vienna/AT)

13.30 Sialidase-inhibiting antibody titers correlate with protection from OP 104 heterologous Influenza virus strains of the same neuraminidase subtype L. Walz, S.-K. Kays (Langen/DE), G. Zimmer (Mittelhäusern/CH) V. von Messling (Langen/DE)

13.45 Non-human Papilloma viruses for gene delivery in vitro and in vivoOP 105 L. Bayer, J. Gumpel (Leipzig/DE), C. Buck (Bethesda, MD/US) M. Muller (Heidelberg/DE), T. Grunwald (Leipzig/DE)

14.00 Induction of mucosal CD8 T cell response by an MCMV based vaccine OP 106 vector and their protective capacity against influenza challenge X. Zheng, L. Cicin-Šain (Braunschweig/DE)

14.15 Harnessing T-helper cell responses induced by licensed vaccines for HIVOP 107 vaccine development H. Elsayed (Erlangen/DE; Dokki, Giza/EG), G. Nabi (Bochum/DE) W. J. Mckinstry (Parkville, Victoria/AU), F. K. Stevenson (Southampton/GB) A. M. Salazar (Washington, DC/US) , M. Tenbusch, V. Temchura K. Überla (Erlangen/DE)

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14.30 Generation of potential live vaccines against Koi herpes virus infection by OP 108 deletion of nonessential viral genes L. Schröder, S. Klafack, S. Bergmann (Greifswald – Isle of Riems/DE) P.-Y. Lee (Taichung/TW), T. C. Mettenleiter W. Fuchs (Greifswald – Isle of Riems/DE)


15.15–16.30 Plenary session 4 – Promoting young scientistsRoom Lecture hall 1

15.15–15.45 Presentations from GfV Working Groups

15.15 Cell biology of virus infectionsIL 10 G. Gerold (Hanover/DE), P.-Y. Lozach (Heidelberg/DE)

15.21 Immunobiology of virus infectionsIL 11 C. Goffinet (Hanover/DE), M. Muhlebach (Langen/DE)

15.27 Viral vectors and gene therapyIL 12 F. Kreppel, A. Ehrhardt (Witten/DE)

15.33 Clinical virologyIL 13 A. Berger (Frankfurt a. M./DE), A. Heim (Hanover/DE)

15.39 Opportunities in clinical virology for biologistsIL 14 H. Fickenscher (Kiel/DE)

15.45 Applying successfully for DFG funding – plenary discussionIL 15 H.-G. Kräusslich (Heidelberg/DE), P. Stäheli (Freiburg/DE)

16.30–18.00 Workshop 19 – Bioinformatics in virologyRoom Lecture hall 1Chairs F. Erhard (Wurzburg/DE), M. Marz (Jena/DE)

16.30 DisCVR – rapid viral diagnosis from high-throughput sequencing dataOP 109 J. Hughes, A. Davison, M. Palmarini, M. Maabar (Glasgow/GB)

16.45 ViMiFi – de novo prediction of viral mircoRNAsOP 110 K. Lamkiewicz, M. Marz (Jena/DE)

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17.00 Cellular proteomic analysis of porcine circovirus type 2 and classical swine OP 111 fever virus coinfection in porcine kidney-15 cells using isobaric tags for relative and absolute quantitation-coupled LC-MS/MS N. Zhou (Zhejiang/CN), S. Wang (Nanjing/CN) J. Zhou (Nanjing, Zhejiang/CN), J. Gu (Nanjing/CN)

17.15 3D spatially resolved models of the intracellular dynamics of the Hepatitis OP 112 C genome replication cycle M. M. Knodel, A. Nägel (Frankfurt a. M./DE) P. Targett-Adams (Huddinge/SE), J. McLauchlan (Glasgow/GB) E. Herrmann, G. Wittum (Frankfurt a. M./DE)

17.30 MHC-I broadly presents – sORF derived peptidesOP 113 F. Erhard (Wurzburg/DE), A. Halenius, C. Zimmermann (Freiburg/DE) A. L’Hernault (Cambridge/GB), D. Kowalewski (Tubingen/DE) M. Weekes (Cambridge/GB), S. Stevanovic (Tubingen/DE) R. Zimmer (Munich/DE), L. Dölken (Wurzburg/DE)

17.45 Viral host prediction with deep learningOP 114 F. Mock, A. Viehweger, M. Marz (Jena/DE)

16.30–18.00 Workshop 20 – Intracellular transport and traffickingRoom Lecture hall 2Chairs E. Herker (Hamburg/DE), M. Schelhaas (Munster/DE)

16.30 New insights into trafficking of Marburg virus glycoprotein employing OP 115 image analysis S. Halwe, S. Becker, O. Dolnik (Marburg/DE)

16.45 Quantitating the transfer of the HTLV-1 p8 protein between T-cells by OP 116 flow cytometry N. Donhauser, S. Heym, A. K. Thoma-Kress (Erlangen/DE)

17.00 The role of cellular tetraspanins in HCV particle trafficking and egressOP 117 M. Bunz (Tubingen/DE), J. Nehls, M. Schindler (Tubingen, Munich/DE)

17.15 Amber suppression mediated genetic code expansion as a novel tool for OP 118 labelling and live-cell imaging of HBV core protein B. Zehnder, G. Estrada Girona, E. A. Lemke, S. Urban (Heidelberg/DE)

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17.30 Anterograde transport of fi eld RABV G protein is highly regulated in OP 119 primary neuronal cells V. te Kamp (Greifswald – Isle of Riems/DE), T. Nolden (Innsbruck/AT) S. Nemitz, S. Finke (Greifswald – Isle of Riems/DE)

17.45 Axonal tracing of fl uorescence-labeled Varicella-zoster virus proteins in OP 120 antero- and retrograde infecti on of embryonic rat dorsal root ganglia H. Taher, T. Spieckermann (Kiel/DE) S. Nemitz (Greifswald – Isle of Riems /DE), G. Maschkowitz H. Fickenscher (Kiel/DE)

16.30–18.00 Workshop 21 – Epidemiology and public healthRoom Lecture hall 3Chairs A. Heim (Hanover/DE), J. F. Drexler (Berlin/DE)

16.30 Low Zika virus seroprevalence among pregnant women in North-Central OP 121 Nigeria in 2016 P. Mathé (Freiburg/DE), D. Egah, N. Shehu (Jos/NG) E. Obishakin (Vom-Jos/NG), S. David, V. Pam, O. Ojogba, C. Yilgwan S. Gomerep (Jos/NG), J. Fuchs (Freiburg/DE), I. Abok, K. Onyedibe E. Olugbo, S. Isa (Jos/NG), S. Machunga-Mambula (Abuja/NG) C. Att ah (Keffi /NG), S. Oguche (Jos/NG), M. Panning (Freiburg/DE)

16.45 Zika virus infecti on in human placental ti ssue explants is enhanced in the OP 122 presence of Dengue virus anti bodies K. Hermanns (Berlin/DE), C. Göhner (Jena, Bonn/DE), A. Kopp (Berlin/DE) A. Schmidt (Jena/DE), W. Merz (Bonn/DE), U. Markert (Jena/DE) C. Drosten, S. Junglen (Berlin/DE)

17.00 Molecular surveillance reveals a recent outbreak of HIV-1 subtype C OP 123 infecti ons among people who inject drugs (PWID) in Munich, Germany K. Hanke, A. Hauser, A. Hofmann, B. Gunsenheimer-Bartmeyer, V. Bremer N. Bannert (Berlin/DE)

17.15 Infl uenza C virus in children with respiratory infecti ons – data from the OP 124 inati onal infl uenza surveillance system in Germany, 2012–2014 A. Fritsch, B. Schweiger, B. Biere (Berlin/DE)

17.30 Can we predict the spati al origin of Hanta virus infecti ons in humans using OP 125 sequences derived from a generic screening PCR? S. Weiss, B. Auste, D. H. Kruger, J. Hofmann (Berlin/DE)

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17.45 The impact and longevity of measles-associated immune suppression:OP 126 A populati on based matched cohort study K. Gadroen, C. Dodd, G. Masclee, M. de Ridder, D. Weibel (Rott erdam/NL) M. Mina (Boston, MA/US), B. Grenfell (Princeton, NJ/US) M. Sturkenboom, D. van de Vijver, R. de Swart (Rott erdam/NL)

18.00–19.30 Poster session 3Room 2+3, 5, 7–9, 11–12 Clinical virology, Epidemiology and public health, Host cell factors and viral modulati on 1+2, Vaccines

(Please refer to page 90 to take a look at the poster fl oor plan and the poster session overview.) 20.00–01.00 Social eveningRoom Mensa (please refer to page 115)

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SCIENTIFIC PROGRAMME • SATURDAY, 17 MARCH

09.00–10.30 Workshop 22 – Host cell factors and viral modulation 2Room Lecture hall 1Chairs A. Ruggieri (Heidelberg/DE), S. Stertz (Zurich/CH)

09.00 Viral epitranscriptomicsOP 127 B. Cullen (Durham, NC/US)

09.15 Global transcriptome analyses reveal extensive suppression of antiviral OP 128 immune responses by the HIV-1 accessory protein Vpu S. Langer (Ulm/DE; La Jolla, CA/US), C. Hammer (Lausanne/CH) K. Hopfensperger, L. Klein, D. Hotter (Ulm/DE), P. de Jesus, L. Pache S. Chanda (La Jolla, CA/US), J. Fellay (Lausanne/CH), F. Kirchhoff D. Sauter (Ulm/DE)

09.30 Rapid polycomb recruitment is not a universal feature of latently OP 129 replicating gammaherpesvirus genomes T. Gunther (Hamburg/DE), S. Ohno (Munich/DE), L. Burkhardt J. Fröhlich (Hamburg/DE), H. Adler (Munich/DE), A. Grundhoff (Hamburg/DE)

09.45 The vGPCR pUS27 of HCMV induces the expression of chemoattractant OP 130 cytokines and is restrained by PDZ proteins regulating epithelial polarity T. Frank, I. Niemann, A. Reichel (Erlangen/DE), M. Scherer (Ulm/DE) S. Mahmoudian, B. Krenz, J. Hofmann, B. Biesinger, H. Sticht (Erlangen/DE) T. Stamminger (Ulm/DE)

10.00 CD302 as a novel restriction factor for Hepatitis C virusOP 131 B. Tegtmeyer, R. Brown (Hanover/DE), C. Lauber (Dresden/DE) F. Vondran, T. Pietschmann (Hanover/DE)

10.15 Apobec3A is a novel restriction factor antagonising efficient HAdV OP 132 replication C. Weiß, D. Stadler, U. Protzer, S. Schreiner (Munich/DE)

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09.00–10.30 Workshop 23 – Clinical virologyRoom Lecture hall 2Chairs O. Adams (Dusseldorf/DE), A. Berger (Frankfurt a. M./DE)

09.00 Interim results of a multicenter, open-label phase 2b clinical trial to assessOP 133 the safety and efficacy of Mycrludex B in combination with tenofovir in patients with HBV/HDV coinfection H. Wedemeyer (Hanover/DE), P. Bogomolov (Moscow/RU) A. Blank (Heidelberg/DE), B. Bremer (Hanover/DE) N. Voronkova (Moscow/RU), K. Schöneweis (Heidelberg/DE), R. Raupach P. Lehmann, M. Darnedde (Hanover/DE), A. Pathil J. Burhenne (Heidelberg/DE), M. Haag, M. Schwab (Tubingen, Stuttgart/DE) W. E. Haefeli (Heidelberg/DE), A. Alexandrov (Burgwedel/DE) S. Urban (Heidelberg/DE)

09.15 Hepatitis C virus screening project of patients on current anti-HCV OP 134 therapy E. Knops (Cologne/DE), P. Kalaghatgi (Saarbrucken/DE) E. Heger (Cologne/DE), V. Keitel-Anselmino (Dusseldorf/DE) T. Goeser (Cologne/DE), N. Schubel (Osnabruck/DE) T. von Hahn (Hanover/DE), N. Qurishi, K. Römer, S. Scholten (Cologne/DE) M. Däumer (Kaiserslautern/DE), M. Obermeier (Berlin/DE) N. Lubke (Dusseldorf/DE), R. Kaiser, S. Sierra (Cologne/DE)

09.30 Role of BK-Polyoma virus (BKV) and Torque teno virus (TTV) in liver OP 135 transplant recipients with renal impairment A. Herrmann (Essen/DE), L. Sandmann (Hanover/DE) O. Adams (Dusseldorf/DE), M. Widera, S. Westhaus (Essen/DE), R. Kaiser V. di Cristanziano (Cologne/DE), J. Timm (Dusseldorf/DE), M. Manns T. von Hahn (Hanover/DE), S. Ciesek (Essen/DE)

09.45 Thirty cases of Entero virus-D68 associated acute flaccid myelitis in EuropeOP 136 2016 – a case series and epidemiological overview B. Niesters, J. Helfferich, M. Knoester, R. Poelman, O. Brouwer C. Van Leer-Buter (Groningen/NL)

10.00 Impact of pharmacokinetics on the efficiency of CMV-specific hyperimmuneOP 137 globulin treatment in early CMV-primary infection during pregnancy K. Hamprecht, K.-O. Kagan, M. Schampera, G. Jahn (Tubingen/DE)

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10.15 Consequences of MMR vaccination gaps in young adults – measles OP 138 infections in pregnancy and in the newborn S. W. Aberle, E. M. Geringer, D. Schmid, B. Volc-Platzer (Vienna/AT) E. Hattinger-Jurgenssen (Salzburg/AT), T. Popow-Kraupp H. Holzmann (Vienna/AT)

10.45–12.15 Plenary session 5 – Next-generation sequencing in clinical virologyRoom Lecture hall 1Chairs O. T. Keppler (Munich/DE), A. Ensser (Erlangen/DE)

10.45 Application of NGS for HIV and HCV in clinical routineIL 16 M. Obermeier (Berlin/DE)

11.15 Clinical metagenomics – It is more than “just” identifying novel virusesIL 17 N. Fischer (Hamburg/DE)

11.45 Evolution of human Cytomegalo virus in vivoIL 18 A. Davison (Glasgow/GB)

12.15–12.45 Poster prizes and farewellRoom Lecture hall 1

DIE ALINITY-FAMILIE IST JETZT KOMPLETT!

CHOOSE TRANSFORMATION

Klinische Chemie • Immunoassay • Hämatologie Blutspenderscreening • Molekulardiagnostik Point of Care • Professionelle Dienstleistungen

2018AM-DE-001v1

4th GERMAN PHARM-TOX SUMMIT

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SAVE THE DATE

85th Annual Meeti ng of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and 21st Annual Meeti ng of the Associati on of Clinical Pharmacology (VKliPha) with contributi on of the AGAH

SCANGPTS-KONGRESS.DE

25–28 FEBRUARY STUTTGART l 2019

43

GENERAL INFORMATION

DIE ALINITY-FAMILIE IST JETZT KOMPLETT!

CHOOSE TRANSFORMATION

Klinische Chemie • Immunoassay • Hämatologie Blutspenderscreening • Molekulardiagnostik Point of Care • Professionelle Dienstleistungen

2018AM-DE-001v1

44

POSTER FLOOR PLAN

Entrance

Entrance

First Floor

Second Floor

Posterpresentations

First Floor

Posterpresentations

Ground Floor

Lecture Halls

6

7

8

9 10 11 12

13

14

3

4

5

2 1

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POSTER SESSION OVERVIEW

Posters will be displayed during the whole duration of the conference. The following topics will be included in the respective sessions:

Poster session 1Wednesday, 14 March • 19.00–21.30

Topics Numbers RoomDiagnostic methods and tools P 01 – P 26 1Emerging viruses and zoonosis P 27 – P 64 3+4Evolution of viruses – viruses in evolution P 66 – P 72, P 451 5Innate immunity 1+2 P 73 – P 117 6+7Virus receptors and entry P 118 – P 139 10+11Viral replication strategies 1+2 P 140 – P 155 13

Poster session 2Thursday, 15 March • 15.30–17.30

Topics Numbers RoomAdaptive immunity 1+2 P 156 – P 173 1+2Antiviral therapy and resistance P 174 – P 209 4+5Bioinformatics in virology P 210 – P 219 9Intracellular transport and trafficking P 220 – P 228 11Novel experimental systems and tools in virology P 229 – P 250 12Structure, assembly and egress P 251 – P 266 13Viral pathogenesis and persistence P 267 – P 298 14Viral transformation and oncogenesis P 299 – P 303 10Virus vectors and gene therapy P 304 – P 312 10

Poster session 3Friday, 16 March • 18.00–19.30

Topics Numbers RoomClinical virology P 313 – P 339 2+3Epidemiology and public health P 342 – P 352 5Host cell factors and viral modulation 1+2 P 353 – P 421 7–9Vaccines P 422 – P 449 11+12

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POSTER SESSION 1

Diagnostic methods and tools

P 01A new quantitative PCR assay for automated determination of the human Cytomegalo virus load in EDTA plasma and urineM. Weizenegger, N. Hefner, U. Eigner (Heidelberg/DE)

P 02Human Cytomegalo virus multiple strain infections, genotype distribution and antiviral resistance in hematopoietic stem cell transplantation recipients analysed by next-generation sequencingA. Dhingra (Hanover, Braunschweig/DE), N. Suárez (Glasgow/GB), P. Varanasi, J. ZischkeA. Heim, E. M. Weissinger, T. F. Schulz (Hanover, Braunschweig/DE)A. J. Davison (Glasgow/GB), P. Kay-Fedorov, T. Ganzenmuller (Hanover, Braunschweig/DE)

P 03Functional impairment of CMV-reactive cellular immunity during pregnancyE. Reuschel, S. Barabas, F. Zeman, H. Bendfeldt, A. Rascle, L. DemlB. Seelbach-Goebel (Regensburg/DE)

P 04Technical and clinical validation of a novel, highly sensitive IFN-γ ELISpot assay to monitor CMV-specific cell-mediated immunity in immunocompromised patientsL. Deml, S. Barabas, T. Spindler, R. Kiener, T. Lugner, J. Batzilla, M. Schemmerer, J. KoestlerH. Bendfeldt, A. Rascle, C. Boeger (Regensburg/DE), B. Krueger, B. Kraemer (Mannheim/DE)R. Wagner, B. Banas (Regensburg/DE)

P 05Comprehensive validation of the gene xpert HIV-1 viral load assay prior to system changeoverM. Daeumer, L. Graf, B. Christmann, B. Thiele (Kaiserslautern/DE)J. Becker (Frankfurt a. M./DE)

P 06Comparison of primary and laboratory-adapted Dengue viruses as antigen sources for diagnostic immunoassaysM. Thaler, S. Malafa, J. Aberle, S. Aberle, F. X. Heinz, K. Stiasny (Vienna/AT)

P07zika virus envelope-specific antibodies – production and characterisationS. Akhras, F. Elgner, T. Holzhauser, E. Hildt (Langen/DE)

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P 08Reduced specificity of Erns antibody ELISAs for samples from piglets with MDAs inducedby vaccination of sows with CSF marker vaccine CP7_E2alfD. Meyer (Hanover/DE), W. Loeffen (Lelystad/NL), A. Postel (Hanover/DE)S. Fritsche (Leipzig/DE), P. Becher (Hanover/DE)

P 09The CMV ELISpot assay is superior to the QuantiFERON-CMV assay in predicting protection from CMV reactivation in kidney transplant recipientsS. Gliga, J. Korth, A. Krawczyk, B. Wilde, P. A. Horn, O. Witzke, M. LindemannM. Fiedler (Essen/DE)

P 10Anti-Hepatitis C virus (HCV) IgG avidity assay to distinguish between recent and longstanding infections using dried serum or plasma spotsA. Eshetu, D. Schmidt, K. Meixenberger (Berlin/DE), S. Ross (Essen/DE), M. ObermeierR. Ehret, C.-T. Bock, B. Bartmeyer, V. Bremer, N. Bannert, A. Hauser (Berlin/DE)

P 11A middleware solution to enable connectivity and enhance the workflow management for emergency department patient careB. Niesters, T. Eckmeyer (Groningen/NL), J. Poodt (Bladel/NL)

P 12Protein carbamoylation increases the restimulation of HCMV-pp65-specific T cellsR. Kiener, T. Brunner, S. Barabas, L. Deml, B. Asbach, R. Wagner (Regensburg/DE)

P 13A colorimetric assay for the simultaneously fast detection of Herpes Simplex Virus and itsacyclovir susceptibilityC. Conzelmann, F. Kruger, A. Schubert, D. Michel, J. Munch (Ulm/DE)

P 14A pan-genotypic Hepatitis C virus NS5A amplification method for reliable genotyping andresistance testingA. Walker, K. S. Ennker, A. Graupner, N. Lubke (Dusseldorf/DE), R. Kaiser (Cologne/DE)J. Timm (Dusseldorf/DE)

48

POSTER SESSION 1

P 15Quantification, genotyping, and analysis of resistance-associated substitutions of Hepatitis C virus in dried serum spotB. Wang, A. E. Alemayehu, P. Machnowska, D. Harms, A. Hauser, J. Hofmann, N. BannertC.-T. Bock (Berlin/DE)

P 16Performance of the newly designed Sentosa SQ HCV Genotyping v2.0 assay in HCV genotyping and resistance testing within the PEPSI studyR. Ehret, A. Moritz, S. Breuer, M. Obermeier (Berlin/DE)

P 17Universal sequencing strategies for retroviral vector DNA-IsoformsT. Stellberger, M. Haase, M. Pavlovic, N. Köhler, A. Dinkelmeier, U. BuschA. Baiker (Oberschleißheim/DE)

P 18A novel HRM assay for the simultaneous detection and differentiation of eight Pox virusesof medical and veterinary importanceE. Gelaye (Debre Zeyit/ET)

P 19AlereTM i RSV is a highly sensitive point-of-care test for detection of respiratory syncytialvirus infections in childrenC. Keller, I. Lettermann-Nass, A. Leonhardt, S. Becker (Marburg/DE)

P 20Human polyoma virus JC and BK capsid antibodies as diagnostic markers in patients withprogressive multifocal leucoencephalopathyO. Adams, M. Andrée (Dusseldorf/DE), C. Warnke (Cologne/DE)

P 21Reliable quantification of Hepatitis D virus RNA independent of the genotypeE. Brandenburger, U. Hofmann (Jena/DE), B. Bremer (Hanover/DE), M. DietzschB. Gey (Leipzig/DE), A. Reinhardt (Jena/DE), I. Lachmann (Leipzig/DE)H. Wedemeyer (Hanover/DE)

P 22Fast and direct sample preparation for whole-genome Next Generation Sequencing (NGS)of Hepatitis C virus (HCV)J. Hillung, M. A. Bracho, J. Pons Tamarit, F. González-Candelas (Valencia/ES)

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POSTER SESSION 1

P 23Application of computational tool in personalised medicine of possible prognostic valuefor comorbidities associated with Hepatitis C virus infectionT. Vaz Gago Prata, C. Manchiero, B. Peixoto Dantas, C. Carmo Mazza, A. K. da Silva NunesE. Abdala, F. Mitiko Tengan, M. Cavalheiro Magri (Sao Paulo/BR)

P 24Development of species-independent serological screening assays for the detection and discrimination of antibodies against Henipa virusesA. Balkema-Buschmann, M. Penning, K. Fischer, H. Weingartl, B. Koellner, J. BarrM. H. Groschup (Greifswald – Isle of Riems/DE)

P 25HIV-1 resistance testing – experiences from INSTAND EQA Schemes 2014–2017M. Kammel (Berlin, Dusseldorf/DE), C. Meyer-Weydig (Berlin/DE), O. T. Keppler, J. EberleL. Gurtler (Munich/DE), V. A. J. Kempf, H. F. Rabenau, A. Berger (Frankfurt a. M./DE)K. Überla, K. Korn (Erlangen/DE), F. Klein, R. Kaiser, E. Heger (Cologne/DE)M. Sturmer (Frankfurt a. M./DE), M. Obermeier, M. Schutze, H.-P. Grunert (Berlin/DE)H. Zeichhardt (Berlin, Dusseldorf/DE)

P 26Molecular diagnosis and characterisation of symptomatic, chronic Rota virus infection in a case of an infant with severe combined immunodefiency vaccinated with Rotarix®A. Mas Marques, L. Rosenfeld, G. Klingenberg, S. Niendorf, J. Hofmann, C.-T. BockA. Gratopp, J.-S. Kuhl, J. H. Schulte, H. von Bernuth, S. Voigt (Berlin/DE)

Emerging viruses and zoonosis

P 27The emergent Noro virus variant GII.P17/GII.17 Kawasaki detected in Brazil: Detection and molecular characterisationJ. da Silva Ribeiro de Andrade, T. Machado Fumian, J. P. Gagliardi Leite, M. Assis, G. BelloD. Mir, M. Pereira Miagostovich (Rio de Janeiro/BR)

P 29Adaptation of Avian Influenza A (H9N2) virus from avian to human receptor-binding preferenceM. Wang, Y. Shi, G. F. Gao (Beijing/CN)

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POSTER SESSION 1

P 30Climatic risk influence on MERS-COV vulnerability and case fatality rate in Riyadh, Saudi ArabiaE. Tambo, A. El Dessouky, E. Khater, M. Sowilem (Jeddah/SA)

P 31Experimental risk assessment for Chikungunya virus transmission in EuropeA. Heitmann (Hamburg/DE), S. Jansen (Hamburg, Lubeck, Borstel/DE), R. LuhkenM. Helms (Hamburg/DE), B. Pluskota (Speyer/DE), N. Becker (Heidelberg, Speyer/DE)J. Schmidt-Chanasit (Hamburg, Lubeck, Borstel/DE), E. Tannich (Speyer, Heidelberg/DE)C. Kuhn (Berlin/DE)

P 32Coinfection with severe fever with thrombocytopenia syndrome virus and Orientia Tsutsugamushi in patient, KoreaJ.-H. Kang, J. Huh, K. H. Lee (Jeju/KR)

P 33High seroprevalence of Dengue IgG antibodies indicates that Dengue virus infections are frequent in Central and Eastern SudanA. Adam, T. Schuttoff, S. Reiche, C. Jassoy (Leipzig/DE)

P 34Replicative capacity of emerging viruses in bank vole and common vole cell linesF. Binder, U. Ziegler, F. Stoek, R. Riebe (Greifswald – Isle of Riems/DE)S. Essbauer (Munich/DE), M. Lenk, S. Reiche, R. Ulrich (Greifswald – Isle of Riems/DE)

P 35Presence of porcine Pegi virus in domestic pigs and phylogenetic analysis of Pegi virus strains from different countries in Europe and AsiaJ. Kennedy, C. Baechlein, D. Hoeltig, P. Becher (Hanover/DE)

P 36Effect of pre-existing heterologous Flavi virus immunity on the zika virus antibody responseS. Malafa, J. Aberle, S. Aberle, D. Haslwanter, I. Medits, G. Tsouchnikas (Vienna/AT)P. Cherpillod (Geneva/CH), E. Percivalle (Pavia/IT), S. Wölfel (Munich/DE), F. X. HeinzK. Stiasny (Vienna/AT)

P 37Genetic and clinical characterisation of a novel Bluetongue virus isolated from infected commercial vaccineO. Erster, V. Bumbarov, N. Golender, Y. Khinich (Rishon LeZion/IL)

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POSTER SESSION 1

P 38Hepatitis E virus infections in zoo animalsC. Spahr (Leipzig, Stuttgart/DE), T. Knauf-Witzens (Stuttgart/DE)T. W. Vahlenkamp (Leipzig/DE)R. Ulrich (Greifswald – Isle of Riems, Hamburg, Lubeck, Borstel/DE), R. Johne (Berlin/DE)

P 3910 years network „Rodent-borne pathogens“R. Ulrich (Greifswald – Isle of Riems/DE), J. Jacob (Munster/DE), G. Heckel (Bern/CH)M. Beer (Greifswald – Isle of Riems/DE), S. Essbauer (Munich/DE), M. Pfeffer (Leipzig/DE)

P 40Banana pipistrelle bats (Neoromicia nanus) are a natural host for Hanta viruses in Côte d’IvoireL. Kouadio (Berlin/DE; Bingerville/CI), S. Köndgen, K. Nowak, S. Weiss (Berlin/DE)E. Couacy-Hymann (Bingerville/CI), B. Klempa (Bratislava/SK), P. T. Witkowski, D. H. KrugerS. Calvignac-Spencer, F. H. Leendertz (Berlin/DE)

P 41Nipah virus replication and cytokine induction differs in human airway cultures from theupper and lower respiratory tractM. Elvert, L. Sauerhering, A. Heiner, A. Maisner (Marburg/DE)

P 42Viral infection in camels – implication on human healthO. Laskar (Levy), S. Melamed (Ness Ziona/IL), O. Erster (Beit Dagan/IL), N. ParanS. Weiss (Ness Ziona/IL), I. Khinich, B. Gelman (Beit Dagan/IL), A. Salomoni (Beer Sheba/IL)

P 43Contribution of free-range ducks to the genesis of novel H5 influenza viruses in BangladeshR. Elshesheny (Memphis, TN/US; Cairo/EG), S. Barman (Memphis, TN/US)M. M. Feeroz (Dhaka/BD), R. G. Webster (Memphis, TN/US)

P 44Bafilomycin A1 efficiently inhibits infection by zIKVC. Sabino, S. Brumhard, D. Ploen, K. Himmelsbach, S. Akhras, F. Elgner (Langen/DE)E. Hildt (Langen, Braunschweig/DE)

52

POSTER SESSION 1

P 45Characterisation of synthetically-derived bat Mumps virusN. Kruger (Hanover/DE), C. Sauder (Silver Spring, MD/US), S. Huttl, K. VoigtG. Herrler (Hanover/DE), K. Hardes, T. Steinmetzer (Marburg/DE), C. Rvell (Stockholm/SE)J. F. Drexler, M. Muller, C. Drosten (Berlin/DE), S. Rubin (Silver Spring, MD/US)M. Hoffmann (Göttingen/DE)

P 46Wild boar serves as wild animal reservoir for Atypical Porcine Pesti Virus (APPV)G. N. Cagatay (Hanover/DE), A. Antos (Puławy/PL), D. Meyer, C. Maistrelli, O. KeulingA. Postel, P. Becher (Hanover/DE)

P 47Molecular characterisation of small ruminant Lenti viruses in single-species flocks reveals circulation of novel subtypes in the goat population in PolandJ. Kuzmak, M. Olech (Pulawy/PL), S. Valas (Niort/FR)

P 48Surveillance for middle east respiratory syndrome Corona virus in camels in EgyptM. Shehata, A. Kandeil (Cairo/EG), R. El-Shesheny (Cairo/EG; Memphis, TN/US)A. Mostafa (Giessen/DE; Cairo/EG), G. Kayali (Memphis, TN/US; Baabda/LB), M. Ali (Cairo/EG)

P 49Semen inhibits zika virus infection of cells and tissues from the anogenital regionJ. Müller, M. Harms, F. Kruger, S. Joas, R. Groß, M. Hayn, N. Sandi-Monroy, A. DietzS. Lippold, J. von Einem, A. Schubert, B. Mayer (Ulm/DE), M. Cortese (Heidelberg/DE)K. Jang (San Francisco, CA//US), M. Deniz (Ulm/DE), F. Ebner (Ulm, Dachau/DE)R. Bartenschlager (Heidelberg/DE), J. Schmidt-Chanasit (Heidelberg, Hamburg/DE)N. Roan (San Francisco, CA/US), J. Munch (Ulm/DE)

P 50Detection and genetic characterisation of porcine Kobu virus in Southwestern ChinaY. Deng, S. Wang (Xichang/CN), T. Lin (Brookings, SD/US)

P 51Virulence and adaptation markers in historic and recent European H10Nx viruses in vivoand in vitroA. Dittrich, U. Blohm, F. Winter, A. Salaheldin, M. Gischke, D. Scheibner, J. VeitsT. C. Mettenleiter, E. Abdelwhab (Greifswald – Isle of Riems/DE)

In the face of diagnostic uncertainty, fast and accurate

molecular diagnostics are the right answer. Fight back

against antibiotic resistance with diagnostics � rst.

Join the conversation at www.diagnostics� rst.com

... as the best prescription.

53

POSTER SESSION 1

In the face of diagnostic uncertainty, fast and accurate

molecular diagnostics are the right answer. Fight back

against antibiotic resistance with diagnostics � rst.

Join the conversation at www.diagnostics� rst.com

... as the best prescription.

54

POSTER SESSION 1

P 52Marburg virus VP30 alleviates the unfolded protein response by interacting with the XBP1u protein/XBP1u mRNA complexC. Rohde, S. Becker, V. Krähling (Marburg/DE)

P 53First evidence of Peste des Petits Ruminants Virus (PPRV) infection in gazelles in the Sudan 2016–2017R. Asil (Khartoum-North, Khartoum/SD), N. Osman (Khartoum-North/SD), A. BallalS. Alsarraj, W. Ali, B. Mohamed, S. Mutwakil (Khartoum/SD)

P 55Sequence and phylogenetic analysis of the haemagglutinin and fusion protein sequencesof Peste des Petits Ruminants Virus Kurdistan 2011, a member of PPRV lineage IVN. A. Osman (Khartoum-North/SD; Greifswald – Isle of Riems/DE), J. VeitsG. Keil (Greifswald – Isle of Riems/DE)

P 56Transmission of Porcine Cyto Megalo Virus (PCMV) by xenotransplantation of pig hearts to baboonsU. Fiebig (Berlin/DE), J.-M. Abicht (Berlin, Munich/DE), T. Mayr, M. Längin (Munich/DE)E. Plotzki (Berlin/DE), A. Bähr (Munich, Oberschleißheim/DE), S. GuethoffA. Falkenau (Munich/DE), N. Klymiuk (Oberschleißheim, Munich/DE)E. Wolf (Oberschleißheim/DE), B. Reichart (Munich/DE), T. Shibahara (Tsukuba/JP)J. Denner (Berlin/DE)

P 57Elimination of Porcine Cytomegalo Virus (PCMV) from a herd of donor pigs generated forxenotransplantationA. Bähr (Oberschleißheim, Munich/DE), U. Fiebig (Berlin/DE), B. KesslerS. Egerer (Oberschleißheim/DE), B. Reichart (Munich/DE), E. Wolf (Oberschleißheim/DE)J. Denner (Berlin/DE)

10–14 JUNE 2018AACHEN • GERMANYOLD IMPERIAL CITY IN THE HEART OF EUROPE

15th International Symposium on

DENDRITIC CELLSJOINTLY ORGANIZED BY DUTCH AND GERMAN SCIENTISTS

www.dc-2018.com © davis - Fotolia.com© davis - Fotolia.com© davis - Fotolia.com© davis - Fotolia.com

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POSTER SESSION 1

P 58A novel clade of group A Rota viruses associated with fatal disease in domestic pigeons inGermanyD. Rubbenstroth (Freiburg/DE), H. Bartels (Hanover/DE), E. Peus (Essen/DE), E. SchrammD. Kottmann (Freiburg/DE), N. Fischer (Hamburg/DE), C. McCowan (Bundoora/AU)V. Akimkin (Fellbach/DE), C. Schulze, A. Hlinak (Frankfurt a. d. O./DE), E. GrossmannA. Spadinger (Aulendorf/DE), H. Petersen, S. Rautenschlein, L. Mohr (Hanover/DE)

P 59Diversity of Corona viruses in South African chiroptera revealed by optimised screening assayW. Preiser, N. Cronjé, N. Ithete, T. Suliman (Cape Town/ZA)

P 60Vector competence of German Aedes japonicus japonicus for zika virusS. Jansen, A. Heitmann, R. Luhken, H. Jöst, M. Helms (Hamburg/DE), O. Vapalahti (Helsinki/FI)J. Schmidt-Chanasit, E. Tannich (Hamburg/DE)

P 61Recombinant modified Vaccinia virus ankara delivering g and f antigens of Nipah virusS. Veit, G. Sutter, A. Volz (Munich/DE)

P 62Establishment of serological tests for the detection of zaire Ebola virus in swineK. Fischer (Greifswald – Isle of Riems/DE), J. Jabaty (Teko/SL), R. Suluku (Bo City/SL)A. Groseth, A. Balkema-Buschmann, K. M. Schmidt, M. H. Groschup, T. HoenenS. Diederich (Greifswald – Isle of Riems/DE)

P 63Functional characterisation of polymorphisms in the receptor binding domain of the Middle East respiratory syndrome Corona virus spike glycoproteinH. Kleine-Weber, M. T. Elzayat, M. Hoffmann, S. Pöhlmann (Göttingen/DE)

P 64Protease choice for priming of the Middle East respiratory syndrome Corona virus spikeglycoproteins is cell line dependentH. Kleine-Weber, M. T. Elzayat, S. Gierer, M. Hoffmann, S. Pöhlmann (Göttingen/DE)

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POSTER SESSION 1

Evolution of viruses – viruses in evolution

P 66High virulence of a natural H4N2 avian influenza virus with a polybasic cleavage motif after mutation in the hemagglutinin or reassortment with highly pathogenic H5N1 virusM. Gischke, F. Winter, D. Scheibner, A. Salaheldin, J. Veits, T. C. MettenleiterE. Abdelwhab (Greifswald – Isle of Riems/DE)

P 67Isolation and complete genomic sequence of a novel rhesus macaque foamy virus isolatewith a serotype 1-like envA. Ensser (Erlangen/DE), A. Großkopf, K. Mätz-Rensing, C. Roos, A. Hahn (Göttingen/DE)

P 68Evolution of human Cytomegalo virus due to antiviral drug treatment of a transplant patientN. Suarez (Glasgow/GB), S. Avdic, B. Withers, E. Blyth, D. Gottlieb (Sydney/AU)A. Davison (Glasgow/GB), B. Slobedman (Sydney/AU)

P 69Molecular investigation on feline retroviruses among domestic cats in TurkeyB. T. Koc (Aydın, Ankara/TR), T. Ç. Oguzoglu (Ankara/TR)

P 70Molecular evolution of human adenovirus species C by recombination of the E4 RegionA. Dhingra, T. Ganzenmuller, E. Hage, A. Heim (Hanover/DE)

P 71High abundance and genetic variability of the newly discovered Atypical Porcine Pesti Virus (APPV)A. Postel, D. Meyer, G. N. Cagatay (Hanover/DE), N. Fischer, A. Grundhoff (Hamburg/DE)P. Becher (Hanover/DE)

P 72A risk assessment study to investigate the zoonotic potential of SARS-CoV-related virusespresent in European horseshoe batM. Hoffmann (Göttingen/DE), T. Gutzkow, N. Kruger (Hanover/DE), M. A. MullerJ. F. Drexler (Berlin/DE), S. Pöhlmann (Göttingen/DE), C. Drosten (Berlin/DE)G. Herrler (Hanover/DE)

P 451 Borna disease virus-1 infection and Borna-like DNA-elements in Crocidura leucodonD. Nobach, J. Muller, S. Herzog (Giessen/DE), M. Eickmann (Marburg/DE)C. Herden (Giessen/DE)

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POSTER SESSION 1

Innate Immunity 1+2

P 73Activation and inhibition of PKR by ambisense RNA virusesM. Weber-Gerlach (Giessen, Marburg/DE), S. K. Fehling, S. Wolff (Marburg/DE)U. Felgenhauer, B. Bank-Wolf (Giessen/DE), M. H. Kainulainen, R. Jacob (Marburg/DE)J. Wulle (Marburg, Giessen/DE), S. Becker, T. Strecker (Marburg/DE)F. Weber (Giessen, Marburg/DE)

P 74Complex interplay between CCHFV Ovarian Tumor (OTU) domain and the innate immuneresponseS. Devignot, F. Weber (Giessen/DE)

P 75Hepatitis D virus replication is sensed by MDA5 and induces antiviral IFN-β/λ responses in hepatocytesZ. Zhang, C. Filzmayer, Y. Ni, H. Sultmann, M.-S. Hiet, P. Mutz (Heidelberg/DE)F. W. R. Vondran (Hanover/DE), R. Bartenschlager, S. Urban (Heidelberg/DE)

P 76Interferon response in the context of virulent street Rabies virusL. Zaeck, S. Finke (Greifswald – Isle of Riems/DE)

P 77How innate immunity to HIV is differentially regulated by IFNα subtypesJ. Ickler, U. Dittmer, K. Sutter (Essen/DE)

P 78Restriction and innate sensing of HIV-1 in macrophages – Mx2-mediated inhibition of nuclear entry and development of a transdifferentiated, macrophage-like cell modelS.-M. Schwarz (Frankfurt a. M./DE), Q. Xiao, M. Stern, R. v. Dijk-Blom, M. AlbaneseS. Bauernfried, V. Hornung (Munich/DE), O. T. Keppler (Frankfurt a. M., Munich/DE)

P 79Vitamin D-mediated attenuation of miR-155 in human macrophages exposed to Dengue virus – implications for DENV-induced inflammatory responseJ. Arboleda, G. Fernandez, S. Urcuqui-Inchima (São Paulo/BR)

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POSTER SESSION 1

P 80Establishment of bone marrow-derived dendritic cells from microbats for the study of Ebola virus infectionK. Edenborough, M. Bokelmann, G. Holland (Berlin/DE), E. Couacy-Hymann (Bingerville/CI)M. Laue, A. Kurth (Berlin/DE), J. Prescott (Montana, MT/US)

P 81IFI16 and other PYHIN proteins inhibit lentiviral gene expressionM. Bosso, D. Hotter (Ulm/DE), K. L. Jønsson (Aarhus/DK), M. Mayer, S. EngelhartD. Krnavek (Ulm/DE), M. R. Jakobsen (Aarhus/DK), D. Sauter, F. Kirchhoff (Ulm/DE)

P 82Murine Cytomegalo virus recruits the retromer complex to promote NEMO degradation by autophagyE. Muscolino, R. Brost, M. Rizzato, E. Krause (Hamburg/DE), S. Loroch (Dortmund/DE)V. Juranic Lisnic (Rijeka/HR), W. Brune (Hamburg/DE)

P 83IL-27 strongly induces the antiretroviral restriction factor GBP5L. Koepke, A. Blötz, D. Hotter, E. Reith, D. Sauter, F. Kirchhoff (Ulm/DE)

P 84Murine Cytomegalo virus evades the restriction factor SAMHD1 by inducing its phosphorylationJ. Deutschmann, A. Schneider, S. Wittmann, T. Winkler (Erlangen/DE)L. Wiebusch (Berlin/DE), T. Gramberg (Erlangen/DE)

P 85Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responsesH. Welsch, K. Heine (Heidelberg/DE), C. Urban (Munich/DE), C. Dächert (Heidelberg/DE)A. Pichlmair (Munich/DE), M. Binder (Heidelberg/DE)

P 86Kinetic characterisation of the RIG-I signal transduction pathwayM. Binder, S. Niesik (Heidelberg/DE)

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POSTER SESSION 1

P 87Identification of ifitm family members as hiv-1 restriction factors in a plasmacytoid dendritic cell (pdc) lineP. Schuster, L. Thuringer, F. König, M. Herbst, L. Wunderlich, J. AckermannN. Kauer (Regensburg/DE), M. Narita, M. Takahashi (Niigata/JP), A. RohrhoferB. Schmidt (Regensburg/DE)

P 88MHC-I expression in equine dermal and peripheral blood mononuclear cells in vitro afterinfection with different strains of equine Herpes virus type 1 (EHV-1)A. Golke, J. Cymerys, T. Dzieciatkowski, A. Chmielewska, A. Tucholska, J. BrzezickaA. Słońska, M. W. Banbura (Warsaw/PL)

P 89Functional analyses of primary HIV-1 Vpr alleles and potential Vpr effects on innate immune sensingA. Darius, K. Boldt, M. Ueffing (Tubingen/DE), S. M. Hauck (Munich/DE), K. MeixenbergerN. Bannert (Berlin/DE), M. Schindler (Tubingen/DE)

P 90Exposure of primary human hepatocytes to Hepatitis B Virus (HBV) results in toll-like receptor 2 activationZ. Zhang, M. Trippler, C. Real, M. Werner, T. Kemper, A. Paul, G. Gerken, J. Schlaak, M. LuR. Broering (Essen/DE)

P 91Polarised interferon-mediated immune response against enteric pathogens reveal novelmechanisms of immune tolerance in the human gutM. Stanifer, S. Muenchau, D. Albrecht (Heidelberg/DE), S. Bartfeld (Wurzburg/DE)F. van Kuppeveld (Ultrecht/NL), T. Kanaya (Yokohama/JP), S. Boulant (Heidelberg/DE)

P 92Complement and regulatory T cells – the effect of complement on regulatory T cell responses in the friend retrovirus mouse modelJ. A. Ross (Essen/DE), D. Bichler, Z. Banki, H. Stoiber (Innsbruck/AT), U. Dittmer (Essen/DE)

P 93Entrapment of HCMV genomes in PML nuclear cages as a novel intrinsic host defense mechanismM. Scherer (Ulm/DE), A. Reichel (Erlangen/DE), E.-M. Schilling (Ulm/DE), N. ReuterR. Muller (Erlangen/DE), T. Stamminger (Ulm/DE)

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POSTER SESSION 1

P 94Global effects on host cell signaling by continuous stimulation of innate antiviral responses in persistent viral infectionsC. Urban, A. Pichlmair (Munich/DE)

P 95Eurasian avian-like swine influenza viruses gained increased pandemic potential due to the selection of Mx escape mutations in their nucleoproteinP. P. Petric, D. Dornfeld, E. Hassan (Freiburg/DE), R. Zell (Jena/DE), P. StäheliM. Schwemmle (Freiburg/DE)

P 96A placenta derived fragment of ß-hemoglobin with antibacterial and anti-HSV-2 activityF. Krüger, L. Ständker, J. A. Muller, B. Spellerberg, J. Munch (Ulm/DE)

P 97Hunting for a second function of Vaccinia virus strain western reserve protein B14S. W. Böhm, S. Neidel, H. Ren, G. L. Smith (Cambridge/GB)

P 98Human intestinal epithelial cells release antiviral factors that inhibit HIV infection of macrophagesL. Guo, X.-Q. Xu, R.-H. Zhou (Wuhan/CN), X. Wang, J.-L. Li (Philadelphia, PA/US), H. LiuB. Zhang (Wuhan/CN), W.-Z. Ho (Philadelphia, PA/US; Wuhan/CN)

P 99The antiviral specificity of human MxA is affected by allelic variationsL. Graf, G. Kochs (Freiburg/DE)

P 100Tyrosine kinase 2 is not required for interferon-λ-mediated signaling and protection against lethal influenza A virus infection in miceD. Schnepf, L. Polcik, A. Ohnemus (Freiburg/DE), H. H. Gad, R. Hartmann (Aarhus/DK)B. Strobl (Vienna/AT), P. Stäheli (Freiburg/DE)

P 101Exploitation of PKR as a selector for the identification of immunostimulating influenzavirus RNAs useful for antiviral therapyM. Budt, C. Mache, M. Zickler, A. Beling, T. Wolff (Berlin/DE)

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P 102Variants of the immunodominant HCV NS5B2841 epitope presented by HLA-B*27:05 impact the function of KIR3DL1+ NK cellsT. Senff (Dusseldorf/DE), K. Skibbe (Essen/DE), A. Walker (Dusseldorf/DE)N. Scherbaum (Essen/DE), R. Thimme, C. Neumann-Heafelin (Freiburg/DE)S. I. Khakoo (Southampton/GB), J. Timm (Dusseldorf/DE)

P 103Fruit bat tetherin (BST-2, CD317) inhibits spread of highly pathogenic viruses in bat cellsM. Hoffmann, I. Nehlmeier, C. Brinkmann (Göttingen/DE), V. KrählingL. Behner (Marburg/DE), A.-S. Moldenhauer (Göttingen/DE), N. Kruger (Hanover/DE)J. Nehls (Munich, Tubingen/DE), M. Schindler (Tubingen, Munich/DE), A. MaisnerS. Becker (Marburg/DE), S. Pöhlmann (Göttingen/DE)

P 104Virus induced SMARCA2-cleavage by caspases disables the expression of a subset of IFN-stimulated genesA. Dudek, H. Bolte, C. Kontchou, M. Schwemmle (Freiburg/DE)

P 105Mode of action of the RIG-I like receptor LGP2 in the interferon response triggered by viral infectionsN. Gillich, S. Bender, A. Reuter, M. Binder, R. Bartenschlager (Heidelberg/DE)

P 106Toward a characterisation of the type I interferon system of bat cellA. Schön, F. Weber (Giessen/DE)

P 107SUMOylation in the regulation of host antiviral innate immunityC. Patzina, S. Harms, F. Golebiowski (Zurich/CH), M. H. Tatham, R. T. Hay (Dundee/GB)B. G. Hale (Zurich/CH)

P 108Identification of the interferon-inducible C19orf66 as a novel host restriction factor against Hepatitis C virus replicationV. Kinast, A. Kusuma, D. Todt, R. Brown (Hanover/DE)A. Plociennikowska (Heidelberg/DE), M. Engelmann, M. Friesland, A. CarpentierF. W. R. Vondran (Hanover/DE), M. H. Heim (Basel/CH), R. Bartenschlager (Heidelberg/DE)T. Pietschmann, E. Steinmann (Hanover/DE)

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P 109Functionality of the cGAS-Mediated DNA sensing pathway in virus-infected T-CellsC. Elsner, A. Ponnurangam (Hanover/DE), T. Zillinger (Bonn/DE), A. Ducroux, J. KazmierskiK. Döhner, P. Tegtmeyer, S. Xu, A. Malassa, U. Kalinke, B. Sodeik (Hanover/DE)W. Barchet (Bonn/DE), C. Goffinet (Hanover/DE)

P 110Viral infection dynamics of the Culex Y virus and the immune response elicited in insect cellsM. Leggewie (Hamburg/DE), K. Franzke (Greifswald – Isle of Riems/DE), S. JansenA. Heitmann, E. Tannich, E. Schnettler (Hamburg/DE), S. C. Becker (Hanover/DE)

P 111Comparative functional studies on the pestiviral erns proteinS. Koethe, P. König, I. Reimann, M. Beer (Greifswald – Isle of Riems/DE)

P 112Inhibition and tropism of Chikungunya virus infectionS. Franz, J. Bruning, S. Dapa, G. Gerold, T. Pietschmann (Hanover/DE)R. Geffers (Braunschweig/DE), G. Simmons (San Francisco, CA/US), C. Goffinet (Hanover/DE)

P 113Enhanced and conserved anti-interferon activity of multiple Lagos bat virus phosphoproteins in Eidolon helvum bat cells as compared to human cellsJ. Papies, A. Sieberg (Berlin/DE), S. Hauka, D. Ritz (Bonn/DE), D. Niemeyer, D. MuthC. Drosten, M. Muller (Berlin/DE)

P 114The impact of toll-like receptor 9 polymorphisms on Hepatitis B virus clearanceH. Chihab (El Jadida, Casablanca/MA), I. Zaidane (Casablanca/MA), A. El HabaziM. Chair (El Jadida/MA), P. Pineau (Paris/FR), I. Chemin (Lyon/FR), S. EzzikouriS. Benjelloun (Casablanca/MA)

P 115SAMHD1-dependent sensing and restriction of HIV-1 in miceA. Herrmann (Erlangen/DE), R. Behrendt (Dresden/DE), S. Wittmann (Erlangen/DE)A. Roers (Dresden/DE), T. Gramberg (Erlangen/DE)

P 116Crystallization and structural characterisation of the immunomodulatory MCMV proteinM35V. Goncalves Magalhaes, S. Schmelz, J. van den Heuvel, K. Bussow, W. BlankenfeldtM. Brinkmann (Braunschweig/DE)

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P 117Divergent cytokine expression in human monocytes infected with modified Vaccinia virusAnkara (MVA) deficient for dsRNA binding protein E3 expressionM. H. Lehmann, L. E. Torres-Domínguez, C. Brandmuller, G. Sutter (Munich/DE) Virus receptors and entry

P 118Structures of Thogoto virus fusogenic glycoproteins provide clues for virus evolutionR. Peng, S. Zhang, Y. Cui, Y. Shi, G. F. Gao, J. Qi (Beijing/CN)

P 119Functional role of N-linked glycosylation sites in the Pseudorabiesvirus glycoprotein gHM. Vallbracht, B. G. Klupp, T. C. Mettenleiter, W. Fuchs (Greifswald – Isle of Riems/DE)

P 120Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2B. Barbeau (Montreal/CA; Berlin/DE), C. Toudic, X. Elisseeff (Montreal/CA)A. Vargas (Saint-Hyacinthe/CA), Y. Xiao, E. Rassart, J. Lafond (Montreal/CA)N. Bannert (Berlin/DE), S. Sato (Quebec/CA)

P 121HLA-DRB1*15:01 confers susceptibility to EBV infection to B cells – a novel link betweengenetic and environmental risk factors for Multiple SclerosisJ. Menegatti, D. Schub (Homburg/DE), K. Ruprecht (Berlin/DE), F. Grässer (Homburg/DE)

P 122The effect of CEACAM1 on the cell entry of various virusesT. L. Meister, S. Westhaus, B. Singer, V. Khairnar, K. Lang, S. Ciesek (Essen/DE)

P 123Interaction between interferon-induced transmembrane proteins and gamma 2-herpesvirusesC. D’Costa, S. Schlagowski, S. Pöhlmann, A. Großkopf, A. Hahn (Göttingen/DE)

P 124The N-linked glycan in the hemagglutinin affected receptor binding avidity and replication efficiency of the 1968 pandemic influenza viruses J. West, J. Beicht, J. Röder, J. Jansen, J. Baumann, J. Doedt, N. Mounogou KouassiT. Matrosovich, H.-D. Klenk, M. Matrosovich (Marburg/DE)

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AnnuAl ConferenCe 2018of the Association for General and Applied Microbiology

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P 125The disulfide bonds within the antigenic loop and surrounding amino acids are structurally important for the local conformation of the HBV envelope proteinB. S. Möhl, F. Chen, A. Chakraborty, L. Zhao, L. Wolff, U. Protzer (Munich/DE)

P 126Inhibitory effect of soluble platelet-derived growth factor receptor alpha for cell-free human Cytomegalo virus infection with distinct gO genotype mutant strainsI. Goerzer, J. Kalser, I. Kunz (Vienna/AT), B. Adler (Munich/DE)E. Puchhammer-Stöckl (Vienna/AT)

P 127HCoV-OC43, CrCoV and BCoV – attachment and entryA. Szczepanski, K. Owczarek, K. Pyrc (Cracow/PL)

P 128Towards specific glycosaminoglycan structures for HPV binding and infectionL. Soria-Martinez (Munster, Tubingen/DE), S. Bauer, M. GieslerL. Hartmann (Dusseldorf, Tubingen/DE), M. Schelhaas (Munster, Tubingen/DE)

P 129Priming of the HCoV-OC43 S protein – consequences for the fusionK. Owczarek (Kraków/PL), S. Zeglen, J. Wojarski (Zabrze/PL), K. Pyrc (Kraków/PL)

P 130The role of BK Polyoma virus (BKPyV) minor capsid proteins, Vp2 and Vp3, in viral entryS. Henriksen, E. M. Lorentzen (Tromsø/NO), D. McIlroy (Nantes/FR)C. H. Rinaldo (Tromsø/NO)

P 131Native mass spectrometry demonstrates the function of carbohydrates in Noro virus infection pathwaysJ. Lockhauserbäumer, H. Yan (Hamburg/DE), l. Mallagaray, H. Wegener, T. PetersS. Taube (Lubeck/DE), C. Uetrecht (Hamburg, Schenefeld/DE)

P 132A systematic screen to investigate receptor usage of the complete spectrum of human Adeno virusesK. Mese, W. Zhang, J. Gao, O. Bunz, S.-O. Grebe, A. Ehrhardt (Witten/DE)

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© Manfred Rohde l HZI Braunschweig

Conference President Prof. Dr. Dieter Jahn I Technische Universität Braunschweig

sAVe THe DATe

© Instantly l Fotolia.com

P 133Inhibition of HIV-1 infection by HPgV-1 derived peptides is dependent on HPgV-1 genotype and HIV-1 coreceptor tropismT. Rugamer (Regensburg/DE), R. Hoffmann (Erlangen/DE), A. RohrhoferF. Audebert (Regensburg/DE), K. Korn (Erlangen/DE), P. SchusterB. Salzberger (Regensburg/DE), J. Eichler (Erlangen/DE), B. Schmidt (Regensburg/DE)

P 134The cytoplasmic domain of Kumasi virus G protein determines species-specific fusogenicityK. Voigt (Hanover/DE), M. Hoffmann (Göttingen/DE), M. A. Muller, J. F. DrexlerC. Drosten (Berlin/DE), G. Herrler, N. Kruger (Hanover/DE)

P 135Establishment of primary cell cultures from a microbat and study of their host cell factorsfor Filo virus entryM. Bokelmann, K. Edenborough (Berlin/DE), E. Couacy-Hymann (Bingerville/CI)A. Kurth (Berlin/DE)

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P 136Dual-regulatory role of the Morbilli virus attachment protein head-to-stalk linker modulein membrane fusion triggeringM. Herren, N. Shrestha, M. Wyss, P. Plattet (Bern/CH)

P 137Distribution of decay-accelerating factor defines coxsackievirus B3 infectionpattern in induced pluripotent stem cell coloniesJ. Böhnke, N. C. Bilz (Leipzig/DE), S. Pinkert (Berlin/DE), M. StaniferS. Boulant (Heidelberg/DE), M. Jung (Halle a. d. S./DE), U. G. Liebert, C. Claus (Leipzig/DE)

P 138A human in vitro model to study adenoviral receptors and virus-cell interactionsR. L. Tsoukas, E. Ehrke-Schulz, M. Schiwon, J. Gao, K. Mese, W. ZhangA. Ehrhardt (Witten/DE)

P 139Murine Noro virus binding to fucosylated blood group antigen enhancesinfection in vitro and in vivoH. Wegener, l. Mallagaray, A. Domnick, M. Lingemann, M. Klinger (Lubeck/DE), H. TurulaC. E. Wobus (Ann Arbor, MI/US), T. Peters, S. Taube (Lubeck/DE)

Viral replication strategies 1+2

P 140Nuclease and DNA binding domains of human Cytomegalo virus terminase subunit pUL89J. Theiß (Berlin/DE), M. W. Sung (College Station, TX/US)A. Holzenburg (Brownsville, Edinburg, Harlingen, TX/US), E. Bogner (Berlin/DE)

P 141Regulation of foamy virus PolL. Schmidt, J. Bodem (Wurzburg/DE)

P 142Primary murine astrocytes – a novel cell model for investigating mechanisms of Herpes virus infectionA. Sozanska, J. Cymerys, J. Brzezicka, P. Baska, A. Golke, T. DzieciatkowskiM. W. Banbura (Warsaw/PL)

Qual i tätskontrol le für die molekulare Diagnost ikQual i ty Control for Molecular Diagnost ics

Blutübertragbare Viren MultiparameterdiagnostikZentrales Nervensystem Respiratorische ErkrankungenKongenitale Infektionen Wirkstoffresistenz Tropenkrankheiten / “Emerging Diseases“ Serologie Sexuell übertragbare Infektionen Tx-assoziierte ErkrankungenGastrointestinale Erkrankungen TypisierungImmunschwäche-assoziierte Erkrankungen

SERO

MPP

QCMD – Ihr Partner in der Qualitätssicherung der molekularen Diagnostik

www.qcmd.org

QCMD Head Office Todd Campus, West of Scotland

Science Park, Glasgow, Scotland, UK

Tel: +44 (0) 141 945 6474 Fax: +44 (0) 141 945 5795

67

POSTER SESSION 1

P 143Divergent preS sequences in virion associated Hepatitis B virus genomes and HBV surfaceantigen containing particles from HBV e antigen negative patientsK.-H. Peiffer, L. Kuhnhenn (Frankfurt a. M., Langen/DE), B. Jiang (Langen/DE), J. VermehrenV. Knop, S. Zeuzem (Frankfurt a. M./DE), C. Sarrazin (Frankfurt a. M., Wiesbaden/DE)E. Hildt (Langen/DE)

P 144Tegument-derived VP1-2 deubiquitinating activity facilitates the onset of lytic HSV-1 infection in interferon type I treated cellsT. Hennig, J. Mohnke, I. Stark (Wurzburg/DE), P. O’Hare (London/GB), L. Dölken (Wurzburg/DE)

P 145Evaluation of the effect of Staufen-1 on the retroviral particles productionS. Mostafa (Cairo/EG), O. Hohn, N. Bannert (Berlin/DE)

P 146Structure dependent processing of SARS Corona virus polyproteinB. Krichel, S. Falke (Hamburg/DE), R. Hilgenfeld, L. Redecke (Lubeck/DE)C. Uetrecht (Hamburg/DE)

Qual i tätskontrol le für die molekulare Diagnost ikQual i ty Control for Molecular Diagnost ics

Blutübertragbare Viren MultiparameterdiagnostikZentrales Nervensystem Respiratorische ErkrankungenKongenitale Infektionen Wirkstoffresistenz Tropenkrankheiten / “Emerging Diseases“ Serologie Sexuell übertragbare Infektionen Tx-assoziierte ErkrankungenGastrointestinale Erkrankungen TypisierungImmunschwäche-assoziierte Erkrankungen

SERO

MPP

QCMD – Ihr Partner in der Qualitätssicherung der molekularen Diagnostik

www.qcmd.org

QCMD Head Office Todd Campus, West of Scotland

Science Park, Glasgow, Scotland, UK

Tel: +44 (0) 141 945 6474 Fax: +44 (0) 141 945 5795

68

POSTER SESSION 1

P 147Dengue virus protease controls host-translation by cleavage of eIF4G3D. Gertzmann, C. Brosi, U. Fischer, J. Bodem (Wurzburg/DE)

P 148Recombinantly produced virus clones of all 8 different Hepatitis delta genotypes are fullyinfectious in vitro and allow studies of inter-genotypic differencesC. C. Decker, S. Urban, F. Lempp (Heidelberg/DE)

P 149Tolerance of HIV’s late gene expression toward stepwise codon adaptationT. Schuster, B. Asbach, R. Wagner (Regensburg/DE)

P 150Modeling the complete Hepatitis C virus life cycle – from challenges to chancesC. Dächert (Heidelberg/DE), D. Schweinoch (Greifswald – Isle of Riems/DE)A. Pandey (Basel/CH), L. Kaderali (Greifswald – Isle of Riems/DE), M. Binder (Heidelberg/DE)

P 151Single nucleotide polymorphisms in SEC14L2 affect HCV RNA replication of natural occuring isolates in vitroR. Costa, D. Todt, F. Belinchon (Hanover/DE), C. Schenk (Heidelberg/DE)S. Ross (Essen/DE), M. Manns, E. Steinmann (Hanover/DE), V. Lohmann (Heidelberg/DE)T. von Hahn (Hanover/DE), S. Ciesek (Essen/DE)

P 152Human and bat-derived Mumps virus N, P and L proteins are able to interact for efficientreplication activityS. Huttl, N. Kruger (Hanover/DE), M. Hoffmann (Göttingen/DE)

P 153Maintenance of Corona virus genome integrityN. Ebert, V. Thiel (Bern/CH)

P 154Translation of the major capsid protein in the early life cycle of feline Calici virusC. Luttermann (Greifswald – Isle of Riems/DE), C. Urban (Tubingen/DE)

P 155Assessing the importance of influenza neuraminidase in viral replicationB. Loïc, L. Samira (Mittelhäusern/CH), D. Ronald (Bern/CH), Z. Gert (Mittelhäusern/CH)

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Adaptive immunity 1+2

P 156CD137 agonist therapy promotes friend virus – induced tumor cell rejection in chronicallyinfected miceA. Malyshkina, U. Dittmer (Essen/DE)

P 157The p24 family protein TMED10/Tmp21/p24δ1 anchors a viral protein in the endoplasmicreticulum that abolishes MHC class I surface expressionV. R. Ramnarayan, L. Janssen, Z. Hein, N. Lis, S. Ghanwat, S. Springer (Bremen/DE)

P 158Imaging of cytotoxic antiviral immunity while considering the 3R-principle of animal researchL. Otto, G. Zelinskyy, M. Schuster, U. Dittmer, M. Gunzer (Essen/DE)

P 159Modulation of retrovirus-specific CD4+ T cell responses by IFNα subtypesR.-L. Kaiserling, J. Dickow, U. Dittmer, K. Sutter (Essen/DE)

P 160Increased regulatory T cell frequencies after inhibition of the acid sphingomyelinase in vitro and in vivoF. Dennstädt, C. Hollmann, T. Wiese, S. Stonawski, C. Wurst, A. Menke, N. BeyersdorfJ. Schneider-Schaulies (Wurzburg/DE)

P 161Establishment of an Adeno virus dissemination assay to measure protectiv e T-cell responsesA. Keib (Tubingen/DE), Y.-F. Mei (Umea/SE), L. Cicin-Sain (Braunschweig/DE), G. JahnK. Dennehy (Tubingen/DE)

P 162Endemic paramyxoviruses induce T-cells that cross-protect against zoonotic Nipah virus infectionR. de Vries, A. de Jong, R. J. Verburgh (Rotterdam/NL), L. Sauerhering (Marburg/DE)R. S. van Binnendijk (Bilthoven/NL), M. de Graaf, G. Rimmelzwaan (Rotterdam/NL)A. Osterhaus (Hanover/DE), A. Maisner (Marburg/DE), M. P. KoopmansR. de Swart (Rotterdam/NL)

P 163HTSeq analyses of B cell receptor repertoiresS. Kitanovski, M. Saeedghalati, F. Farahpour, R. Kuppers, D. Hoffmann (Essen/DE)

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POSTER SESSION 2

P 164Identification of BK and JC Polyoma virus derived CD8+ T cell epitopesC. Menne, T. Senff, O. Adams, J. Timm (Dusseldorf/DE)

P 165NKG2Cpos NK cells associated with CMV infection inhibit expansion of activated virus-specific CD8 T cellsC. Thöns, E. Bäcker, T. Senff, W. Moskorz, A. Zimmermann, M. Urberg, P. LangJ. Timm (Dusseldorf/DE)

P 166Comparative immunological responses of Lassa fever in human and a small animal modelD. M. Wozniak, L. Oestereich (Hamburg, Lubeck, Borstel, Riems/DE)J. R. Port (Hamburg/DE), E. Pallasch, S. Bockholt (Hamburg, Lubeck, Borstel, Riems/DE)S. Krasemann, C. Muñoz-Fontela, S. Gunther (Hamburg/DE)

P 167Fcγ receptor type I (CD64)-mediated abrogation of the capacity of dendritic cells to activate specific CD8 T cells by IgG-opsonized Friend virus (FV)Z. Banki, R. Werner, D. Bichler, V. Oberhauser (Innsbruck/AT), S. Verbeek (Leiden/NL)U. Dittmer (Essen/DE), H. Stoiber (Innsbruck/AT)

P 168Interleukin-1β expression in the lung – impact on tissue inflammation and formation of tissue-resident memoryD. Lapuente (Erlangen, Bochum/DE), M. Storcksdieck genannt Bonsmann, A. MaaskeV. Stab, V. Heinecke, K. Watzstedt, R. Heß (Bochum/DE), A. M. WestendorfW. Bayer (Essen/DE), C. Ehrhardt (Munster/DE), M. Tenbusch (Erlangen, Bochum/DE)

P 169Large scale screening of HCMV-seropositive blood donors indicates that HCMV effectivelyescapes from antibodies by cell-associated spreadJ. Falk, M. Winkelmann, K. Laib Sampaio, C. Sinzger, R. Lotfi (Ulm/DE)A. Krawczyk (Essen/DE), H. Schrezenmeier (Ulm/DE)

P 170A conformational scaffold presenting epitopes of the Hepatitis C virus E2 Ig-like domain as a tool to probe the humoral immune response in HCV-infected patientsL. Ströh (Hanover/DE), A. Patel (Glasgow/GB), T. Krey (Hanover/DE)

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POSTER SESSION 2

P 171Protein structure shapes immunodominance of human CD4 T cell responses to zika virusM. Koblischke, K. Stiasny, S. Aberle, S. Malafa, J. Schwaiger, M. Kundi, F. X. HeinzJ. Aberle (Vienna/AT)

P 172HIV neutralising antibodies induced by native-like envelope trimers incorporated into a rhabdoviral vector vaccineC. A. Bresk, T. Hofer, S. Wilmschen, M. Krismer, A. Beierfuß (Innsbruck/AT), G. EffantinW. Weissenhorn (Grenoble/FR), M. J. Hogan, A. P. O. Jordan (Pennsylvania, PA/US)D. C. Montefiori, H.-X. Liao (Durham, NC/US), J. E. Schmitz (Aachen/DE)B. F. Haynes (Durham, NC/US), D. von Laer, J. Kimpel (Innsbruck/AT)

P 173Vaccination with a live attenuated Cytomegalo virus mutant lacking an interferon antagonist raises strong humoral immune responses and prevents subsequent challengeinfectionsA. Jagnjic (Essen/DE), I. Brizic (Rijeka/HR), K. Wohlgemuth (Essen/DE), K. HoffmannH. Hengel (Freiburg/DE), S. Jonjic (Rijeka/HR), V. T. K. Le-Trilling, M. Trilling (Essen/DE)

Antiviral therapy and resistance

P 174Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139 have no influence on treatment outcome or its detection by diagnostic assaysH. Mijocevic, H. Karimzadeh, J. Seebach (Munich/DE), M. Al-Mahtab (Dhaka/BD)M. Bazinet, A. Vaillant (Montreal/CA), M. Roggendorf (Munich/DE)

P 175Monitoring for emergence and spread of antiviral resistant influenza virusesS. Duwe, J. Milde, M. Wedde, A. Heider, B. Schweiger (Berlin/DE)

P 176Towards the development of an alternative, locked nucleic acid-based antiretroviral therapyF. Hillebrand, P. Ostermann, D. Degrandi (Dusseldorf/DE), S. Erkelenz (Cologne/DE)M. Widera (Essen/DE), K. Pfeffer, H. Schaal (Dusseldorf/DE)

P 177Analysis of drug resistance associated mutations in splicing regulatory elements affectingHIV-1 replication capacityL. Müller, W. Moskorz, N. Lubke, H. Schaal (Dusseldorf/DE)

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POSTER SESSION 2

P 178A new antiviral approach – broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against Corona- and Picorna virusesC. Müller (Giessen/DE), F. Schulte, K. Lange-Grunweller (Marburg/DE), R. MadhugiriS. Pleschka, J. Ziebuhr (Giessen/DE), R. K. Hartmann, A. Grunweller (Marburg/DE)

P 179Lifecycle modelling systems indicate a role of inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor for efficient New World arenavirus RNA synthesisE. Dunham (Hamilton, MT/US), A. Leske (Greifswald – Isle of Riems/DE), K. ShifflettA. Watt, H. Feldmann (Hamilton, MT/US)T. Hoenen (Greifswald – Isle of Riems/DE; Hamilton, MT/US)A. Groseth (Hamilton, MT/US; Greifswald – Isle of Riems/DE)

P 180High throughput reporter screen to identify inhibitors of clinically relevant human Polyoma virus infectionsE. Kraus (Hamburg, Borstel, Lubeck, Riems/DE), J. Ruckert (Hanover/DE)G. Beauclair, T. Schulz (Hanover, Braunschweig/DE), A. GrundhoffN. Fischer (Hamburg, Borstel, Lubeck, Riems, Hamburg/DE)

P 181Potent inhibition of zika virus replication by silvestrolF. Elgner, C. Sabino, D. Ploen (Langen/DE), A. Grunweller (Marburg/DE)E. Hildt (Langen, Braunschweig/DE)

P 182Inhibition of Hepatitis E virus spread by the natural compound silvestrolM. Glitscher, K. Himmelsbach (Langen/DE), R. Johne (Berlin/DE)A. Grunweller (Marburg/DE), E. Hildt (Langen/DE)

P 183Novel reporter gene induction/expression assay for the identification of compounds interfering with Herpes Simplex Virus type 1 (HSV-1) membrane fusionW. Hafezi, D. Ulrich, M.-L. Romberg, A. Hofemeister (Munster/DE)A.-M. Eis-Hubinger (Bonn/DE), A. Hensel, J. Kuhn (Munster/DE)

P 184Multivalent sialylated polyglycerol derivates inhibit influenza virus propagationM. Stadtmüller, D. Lauster, S. Bhatia, C. Böttcher, A. Herrmann, R. Haag, T. Wolff (Berlin/DE)

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POSTER SESSION 2

P 185A high-throughput screening system for antivirals targeting the human Cytomegalo virus alkaline nucleaseT. Potgieter (Hamburg/DE), J. Ruckert (Hanover/DE), A. Caceres-Nuñez, E. OstermannW. Brune (Hamburg/DE)

P 186The natural compound silvestrol inhibits Hepatitis E Virus (HEV) replication in vitro and in vivoN. Moeller, D. Todt, D. Praditya, V. Kinast, M. Friesland, M. Engelmann (Hanover/DE)L. Verhoye, I. M. Sayed (Ghent/BE), P. Behrendt (Hanover/DE),V. L. Dao Thi (New York, NY/US), P. Meuleman (Ghent/BE), E. Steinmann (Hanover/DE)

P 187Artesunate-derived monomeric, dimeric and trimeric experimental drugs – their unique mechanistic basis and pronounced antiherpesviral activityF. Hahn, T. Fröhlich, T. Frank (Erlangen/DE), L. D. Bertzbach (Berlin/DE), S. Kohrt (Erlangen/DE)B. B. Kaufer (Berlin/DE), T. Stamminger, S. B. Tsogoeva, M. Marschall (Erlangen/DE)

P 189Several immunosupressive drugs inhibit zika virus replicationS. Westhaus, G. Homa (Essen/DE), S. Pfänder (Bern/CH), A. Clarin, S. Ciesek (Essen/DE)

P 190Impact of type I interferon-α (IFN-α) subtypes on zika virus infectionS. Westhaus, G. Homa (Essen/DE), S. Pfänder (Bern/CH), V. Tharmapalan, K. SutterS. Ciesek (Essen/DE)

P 191Inhibitory effect of Crocodylus siamensis liver extract on Influenza A virus replicationT. Meemark (Khon Kaen/TH), A. Mostafa, S. Pleschka, S. Daduang (Khon Kaen/TH; Giessen/DE)

P 192The aminosterol squalamine and derivates – new potential antiviral therapyM. Lovera-Leroux, S. Philippot, M. Trombini (Nancy/FR), J.-M. Brunel (Marseille/FR)M. Varbanov (Nancy/FR)

P 193Genistein inhibits African swine fever virus infection by interfering with DNA synthesisE. Arabyan, H. Zakaryan (Erevan/AM)

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P 194Identification and characterisation of small molecule compounds with activity against Cytomegalo virusS. Nahrevanian, M. Messerle, L. Steinbruck, J. Ruckert (Hanover/DE)

P 195Study of micro RNA-21 expression and detection of transforming growth factor beta amongchronic Hepatitis C patients with response to treatmentA. Gaballah, E. Zaghloul, H. Moustafa (Alexandria/EG), A. Ghazy (Kafr Elsheikh/EG)E. Rashwan (Alexandria, Kafr Elsheikh/EG)

P 19625(OH)-vitamin D3 (Cholecalciferol) inhibits Hepatitis B virus replication in differentiatedHepaRG cells and primary human hepatocytesK. Singethan (Munich/DE), W. Dammermann (Hamburg, Brandenburg/DE), M. FeuerherdM. Kächele (Munich/DE), C. Kuhne, J. Schulze zur Wiesch (Hamburg/DE)U. Protzer (Munich/DE), S. Luth (Hamburg, Brandenburg/DE)

P 197Detection of resistance associated variants to directly acting antiviral agents among chronic Hepatitis C treatment-naive egyptian patientsA. Gaballah, M. Shawky, D. Metwally, A. Elsheredy, O. Kader (Alexandria/EG)

P 198Metabolic conversion of CI-1040 turns an antiviral-acting cellular MEK-inhibitor into an antibacterial compoundC. Bruchhagen (Munster/DE), K. Ohlsen (Wurzburg/DE), S. Niemann, S. LudwigC. Ehrhardt (Munster/DE)

P 199Cationic block copolymers as potent inhibitors of HSV-1 infectionM. Pachota, K. Klysik, A. Synowiec, K. Pyrc, K. Szczubialka, M. Nowakowska (Kraków/PL)

P 200Novel influenza virus inhibitors from the bark of Burkea africanaC. Mair (Jena/DE; Vienna/AT), U. Grienke (Vienna/AT), A. Wilhelm (Bloemfontein/ZA)E. Urban, M. Zehl, J. Rollinger (Vienna/AT), M. Schmidtke (Jena/DE)

P 201Derivatives of platelet-derived growth factor receptor alpha inhibit human Cytomegalo virus (HCMV) efficiently but show reduced binding to their natural ligandsC. Stegmann (Ulm/DE), I. Grimm, P. Lischka (Wuppertal/DE), C. Sinzger (Ulm/DE)

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P 202Effect of cold atmospheric plasma (CAP) on human Adeno virusesO. Bunz, K. Mese, W. Zhang, A. Piwowarczyk, A. Ehrhardt (Witten/DE)

P 203Optimisation of treatment strategies in chronic Hepatitis C virus infection through in vitro testing of DAAsT. Bartsch (Essen/DE), J. Dietz (Frankfurt a. M./DE), R. Costa (Hanover/DE), S. Ross (Essen/DE)M. Manns, T. von Hahn (Hanover/DE), C. Sarrazin (Frankfurt a. M./DE), S. Ciesek (Essen/DE)

P 204New compounds targeting ORF57-mediated enhancement of KSHV gene expressionC. Vogt, E. Naimo, G. Beauclair, J. Ruckert, T. Schulz, J. Bohne (Hanover/DE)

P 205Peptides of the platelet-derived growth factor receptor alpha inhibit cell-associated spread of human Cytomegalo virus (HCMV)K. Laib Sampaio, D. Stöhr (Ulm/DE), R. J. Stanton (Cardiff/GB), C. Sinzger (Ulm/DE)

P 206Mode of action analysis of PDGFR-alpha-derived peptides for inhibition of cell-free and cell-associated spread of human Cytomegalo virus (HCMV)D. Fischer, K. Laib Sampaio, C. Paal, D. Stöhr (Ulm/DE), R. J. Stanton (Cardiff/GB)C. Sinzger (Ulm/DE)

P 207Labyrinthopeptin A1 and A2 efficiently inhibit cell entry of human respiratory syncytial virus in vitro and reduce viral load in vivoS. Blockus, S. Haid, S. M. Wiechert, M. Wetzke (Hanover/DE)H. Prochnow (Braunschweig/DE), R. Dijkman (Bern/CH), B. Wiegmann (Hanover/DE)M.-A. Rameix-Welti (Boulogne-Billancourt/FR), J.-F. Eléouët (Jouy-en-Josas/FR)P. Duprex (Boston, MA/US), V. Thiel (Bern/CH), G. Hansen (Hanover/DE)M. Brönstrup (Braunschweig/DE), T. Pietschmann (Hanover/DE)

P 208Evidence that the antiviral activity of influenza A virus defective interfering particles (DIP)depends on the length of defective genomic segmentsP. Arora, S. Gärtner, N. Bdeir (Göttingen/DE), M. Schwemmle (Freiburg/DE)U. Reichl (Magdeburg/DE), M. Winkler, S. Pöhlmann (Göttingen/DE)

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P 209Discovery of a novel Hepatitis C virus assembly inhibitor targeting p7 discloses new facetsof the p7 structure and functionS. Joecks (Hanover/DE), S. You (North Carolina, NC/US), R. Weller (Hanover/DE), R. HazeC. Richards (North Carolina, NC/US), S. Walther (Hanover/DE), E. BurroughsJ. Keicher (North Carolina, NC/US), E. Steinmann (Hanover/DE)R. Hamatake (North Carolina, NC/US), O. Kalinina (Saarbrucken/DE)T. Pietschmann (Hanover/DE)

Bioinformatics in virology

P 210PCAGO – an interactive web service to analyze RNA-Seq data with principal component analysisR. Gerst, M. Marz, M. Hölzer (Jena/DE)

P 211Design of genus-specific probes and primers for detection and identification of viral DNA in environmental samples using next-generation sequencingK. Khafizov, A. Ayginin, A. Matsvai, E. Pimkina, M. Safonova, V. DedkovG. Shipulin (Moscow/RU)

P 212Temporal dynamics of the lung and plasma viromes in lung transplant recipientsM. Segura-Wang, I. Görzer, P. Jaksch, E. Puchhammer-Stöckl (Vienna/AT)

P 213Nanopore sequencing of human Cytomegalo virus – an evaluation of error rate, de novo assembly, consensus calling, and separation of strains in mixed infectionsR. Orton, A. Da Silva Filipe, A. Davison, Q. Gu, J. Hughes, B. Lau, K. Li, M. Maabar, S. ModhaS. Vattipally (Glasgow/GB)

P 214vRNAsite – Prediction and evaluation of vRNA-vRNA interaction sites between influenzaA vRNAsD. Desirò (Jena/DE), H. Bolte (Freiburg/DE), M. Schwemmle (Jena, Freiburg/DE)M. Marz (Jena/DE)

P 215Multiplex PCR method for robust nanopore sequencing of plum pox other RNA virusesA. Viehweger, C. Diezel, M. Marz (Jena/DE)

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P 216LOCATION – Identifying long range compensatory mutations in viral long read dataK. Lamkiewicz, M. Marz (Jena/DE)

P 217Viral full genome sequencing and haplotype reconstructionS. Krautwurst, M. Marz (Jena/DE)

P 218Prospects of sequencing technologies in the development of phagotherapyM. Alexyuk, P. Alexyuk, A. Turmagambetova, A. Bogoyavlenskiy, V. Berezin (Almaty/KZ)

P 219The transcriptomic landscape of Herpes virus infectionC. Jürges, L. Dölken, F. Erhard (Wurzburg/DE)

Intracellular transport and trafficking

P 220mCMV immunoevasin gp40 downregulates cellular stress marker RAE-1γN. Lis, S. Ghanwat, V. R. Ramnarayan, S. Springer (Bremen/DE)

P 221Glycoprotein 3 of porcine reproductive and respiratory syndrome virus exhibits an unusual hairpin-like membrane topologyM. Zhang, M. Veit (Berlin/DE)

P 222HPV16 induces fusion of autophagy adaptor p62/sequestosome-1 with PML-nuclear bodies to enable infectionL. Florin, L. A. Fast, L. Schweiger, F. Boukhallouk, S. Tenzer, A. Clement (Mainz/DE)

P 223Nuclear trafficking of Nipah virus matrix protein is essential for assembly and efficient virus propagationM. Ringel, A. Heiner, L. Behner, L. Sauerhering, A. Maisner (Marburg/DE)

P 224Relevance of exosomes for the Hepatitis E VirusK. Himmelsbach, M. Glitscher, A. Pellegrino (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

78

POSTER SESSION 2

P 225Expression of recombinant, tagged GP2/3/4 trimer and E protein from equine arteritis virus in mammalian cellsA. Matczuk, M. Ugorski (Wroclaw/PL)

P 226The stress granule protein Staufen-1 interacts with the HERV-K(HML-2) rec protein to assist viral RNA transportA. Block, K. Hanke, O. Hohn, H. Hofmann, N. Bannert (Berlin/DE)

P 227Investigating the possibility of active human Cytomegalo virus capsid transport in the nucleoplasmF. Flomm (Hamburg/DE), E.-M. Borst (Hanover/DE), T. Gunther, R. ReimerC. Schneider (Hamburg/DE), M. Messerle (Hanover/DE), A. Grundhoff (Hamburg/DE)K. Grunewald (Hamburg/DE; Oxford/GB), J. B. Bosse (Hamburg/DE)

P 228Specific Importin alphas are required for different steps of the Herpes Simplex Virus life cycleK. Döhner, A. Ramos-Nascimento, D. Bialy, F. Anderson, A. Buch (Hanover/DE)F. Rother (Berlin-Buch, Lubeck/DE), A. Binz (Hanover/DE), R. J. Lebbink (Utrecht/NL)R. C. Hoeben (Leiden/NL), E. Hartmann (Lubeck/DE), M. Bader (Berlin-Buch, Lubeck/DE)R. Bauerfeind, B. Sodeik (Hanover/DE)

Novel experimental systems and tools in virology

P 229CRISPR/Cas9 in Herpesvirology – viral genome localisation and genome wide screeningfor the identification of antiviral cellular restriction factorsF. Full, D. Jungnickl, N. Teufert, B. Scholz, A. Ensser (Erlangen/DE)

P 230Inhibition of african swine fever virus replication in cell culture mediated by CRISPR/Cas9A. Hübner (Greifswald – Isle of Riems/DE), B. Petersen (Neustadt/DE), T. Kabuuka, G. KeilT. C. Mettenleiter, W. Fuchs (Greifswald – Isle of Riems/DE)

P 231Strategy for efficient generation of numerous full-length cDNA clones of classical swine fever virus derived directly from infected pigsC. Johnston (Kalvehave/DK), U. Fahnøe (Copenhagen/DK), G. J. BelshamT. Bruun Rasmussen (Kalvehave/DK)

79

POSTER SESSION 2

P 232In vitro stimulation of dendritic cells by berberis vulgaris as new treatment protocol for HCVM. Aziz, D. Ghareeb, S. Eweda (Alexandria/EG)

P 233CRISPR/Cas9-mediated inhibition of pseudorabies virus replication in cell cultureW. Fuchs (Greifswald – Isle of Riems/DE), B. Petersen (Neustadt/DE), G. Keil, A. HubnerT. C. Mettenleiter (Greifswald – Isle of Riems/DE)

P 234EBV-associated gastric carcinoma (EBVaGC) – establishment of a novel EBV infection model using 3D human gastric organoidsN. Wallaschek, C. Niklas, M. Pompaiah, S. Kircher, L. Floßbach, A. Rosenwald, A. WiegeringC.-T. Germer (Wurzburg/DE), C. Shannon-Lowe (Birmingham/GB)S. Bartfeld (Wurzburg/DE)

P 235Development and characterisation of an HCV/HEV co-infection modelD. Todt, K. Resner, N. Moeller, M. Friesland (Hanover/DE), P. BehrendtH. Wedemeyer (Hanover, Braunschweig/DE), E. Steinmann (Hanover/DE)

P 236Generation of optimised reverse genetics systems for wild-type strains of human respiratory syncytial virusA. Habierski, A. Schadenhofer (Hanover/DE), T. GanzenmullerT. Schulz (Hanover, Braunschweig/DE), A. Osterhaus, M. Ludlow (Hanover/DE)

P 237Expanding the donor pool – decontamination of HCV RNA Positive Kidneys with Methylene BlueF. Helfritz, V. Wanders, D. Bojkova, N. Kuklisnki, S. Westhaus, U. Rauen (Essen/DE)V. Kinast (Hanover, Essen/DE), E. Steinmann (Hanover/DE), T. Minor, A. Paul (Essen/DE)P. Meuleman (Ghent/BE), S. Ciesek (Essen/DE)

P 238High density peptide microarrays – an essential tool for comprehensive biomarker discovery and virus epitope mappingB. Meyer (Heidelberg/DE), V. Corman, C. Drosten (Berlin/DE), V. Stadler (Heidelberg/DE)

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POSTER SESSION 2

P 239Development of a multiplex focus reduction neutralisation assay for measles and mumpsA. Comvalius, S. Yuksel (Rotterdam/NL), R. van Binnendijk (Bilthoven/NL)P. Duprex (Boston, MA/US), R. de Swart (Rotterdam/NL)

P 240Evaluation and development of efficient virus particles concentration method and its application for the detection of human Corona viruses isolated from cell culture systemsS. Philippot, M. Varbanov (Nancy/FR)

P 241Establish differentiated airway epithelium models from harbor seals to study the courseof infection by viral pathogensD.-L. Shin, N.-H. Wu, A. Reckendorf, F. Meng, U. Siebert, P. Valentin-WeigandG. Herrler (Hanover/DE)

P 242Neuraminidase inhibitors – Is it time to call it a day?C. Parra-Rojas, V. K. Nguyen, G. Hernández-Mejía, E. A. Hernandez-Vargas (Frankfurt a. M./DE)

P 243Blocking serum amine oxidases and using serum-free medium decrease the cytotoxic activity of semenM. Harms, N. Sandi-Monroy, J. Munch (Ulm/DE)

P 245Generation and phenotypic characterisation of novel cloning systems for human Adenovirus types D26, D48 and B35C. Weiß, S. Hofmann, P. Groitl, S. Schreiner (Munich/DE)

P 246Reporter gene expression in the genome of Middle East Respiratory Syndrome Corona virus based on a novel reverse genetics system utilising red-mediated recombination cloningD. Muth (Berlin/DE), B. Meyer (Bonn/DE), D. Niemeyer, S. Schroeder, N. OsterriederM. A. Muller, C. Drosten (Berlin/DE)

P 247Vesicular Stomatitis virus as a surface functionalisation of layer-by-layer microcarriers forimproved drug deliveryK. Scheffler, C. Claus (Leipzig/DE), M. Stanifer, S. Boulant (Heidelberg/DE)U. Reibetanz (Leipzig/DE)

81

POSTER SESSION 2

P 248Isolation and characterisation of novel rat and mouse Papilloma virusesJ. Dichgans, A. Ehrhardt, E. Ehrke-Schulz (Witten/DE)R. Ulrich (Greifswald – Isle of Riems/DE), S. Essbauer (Munich/DE)

P 249BAC cloning, genome sequencing, ribosome profiling, and annotation of human Cytomegalo virus AD169 variants differing in the preservation of the ULb´ regionV. T. K. Le-Trilling, T. Becker (Essen/DE), N. Stern-Ginossar (Rehovot/IL), S. Voigt (Berlin/DE)H. Hengel (Freiburg/DE), M. Trilling (Essen/DE)

P 250Novel approaches to identify cytosolic host proteins interacting with the capsids of Herpes virusesA. Hickford Martinez (Hanover/DE), T. Greco (New Jersey, NJ/US), M. Serrero, F. AndersonD. Kieneke, A. Binz, U. Prank, R. Bauerfeind (Hanover/DE), I. Cristea (New Jersey, NJ/US)B. Sodeik (Hanover/DE)

Structure, assembly and egress

P 251Mapping of disulfide bridges in the Hepatitis B virus small envelope protein SN. Gerstenberg, F. Zörndlein, S. Suffner, V. Bruß (Munich/DE)

P 252Identification, characterisation, and purification of functional domains of the Hepatitis Bvirus HBx proteinM. Leuthold, B. Qu, S. Urban (Heidelberg/DE)

P 253LINCing cellular proteins to nuclear egress of Herpes virusesJ. E. Hölper, B. G. Klupp, K. Franzke, T. C. Mettenleiter (Greifswald – Isle of Riems/DE)

P 254The Cytomegalo virus core NEC protein pUL50 possesses basic functional importance both in vitro and in vivoE. Sonntag (Erlangen/DE), E.-M. Borst (Hanover/DE), S. Häge, P. Tannig, L. SeylerC. Wangen (Erlangen/DE), M. Messerle (Hanover/DE), T. Bäuerle, M. Marschall (Erlangen/DE)

P 255Comparative analysis of core NEC proteins produced by α-, β- and γ-Herpes virusesS. Häge, E. Sonntag, J. Milbradt, Y. Muller, M. Marschall (Erlangen/DE)

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P 256The HTLV-1-induced extracellular matrix protein COL4A2 is critical for virus processing and releaseS. Millen, C. Gross, M. Mann, K. Überla, A. K. Thoma-Kress (Erlangen/DE)

P 257Recapitulation of the complete HDV replication cycle in a novel hepatoma cell line allowsfor efficient antiviral compound evaluationF. Lempp, F. Schlund, L. Rieble, L. Nußbaum, C. Eck, Y. Ni, S. Urban (Heidelberg/DE)

P 258Production and functional characterisation of Hepatitis delta virus enveloped with the surface proteins of eight Hepatitis B Virus genotypesD. Olszewski, F. Lempp, S. Urban (Heidelberg/DE)

P 259Functional study of the C terminal part of HCV E1 ectodomainR. Moustafa, J. Haddad, L. Linna, M. Lavie, J. Dubuisson (Lille/FR)

P 260On the way to unravel the mystery of HPV L2B. Breiner, C. Simon, T. Iftner (Tubingen/DE)

P 261A conserved homodimeric interface of the Hanta virus Gc glycoprotein directs viral particle assembly, acid-induced spike dissociation and membrane fusionE. Bignon (Santiago/CL), P. Guardado-Calvo, F. Rey (Paris/FR), N. Tischler (Santiago/CL)

P 262Vibrational characteristics of zika virus based on symmetry-constrained elastic network modelB. H. Lee, S. Jo, M.-k. Choi, M. K. Kim (Suwon/KR)

P 263Human Cytomegalo virus secondary envelopment requires complex formation of tegument proteins pUL103 and pUL71A. Dietz, K. Mihajluk, C. Villinger, N. Hensel, J. von Einem (Ulm/DE)

P 264The human immunodeficiency virus assembly domain – a focus on lipidsF. Mucksch, W. Muranyi, V. Laketa, M. Gerl, B. Muller, B. Brugger, C. SchultzH.-G. Kräusslich (Heidelberg/DE)

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POSTER SESSION 2

P 265Role of phosphorylation of M1 tyrosine 132 in late stages of the influenza A virus replication cycleA. Mecate-Zambrano, Y. Börgeling, D. Anhlan, L. Greune, L. Wixler, A. SchmidtS. Ludwig (Munster/DE)

P 266Decoding of protein machineries coordinating Hepatitis C virus assembly and releaseS. Joecks (Hanover/DE), A. Frauenstein (Planegg/DE), J. Bruning, G. Gerold, R. BrownG. Vieyres (Hanover/DE), L. Kaderali (Greifswald – Isle of Riems/DE)F. Meissner (Planegg/DE), T. Pietschmann (Hanover/DE)

Viral pathogenesis and persistence

P 267Transcription of human endogenous Retro virus HERV-K(HML-2) loci in amyotrophic lateral sclerosis and potential implications for expression of HML-2-encoded proteinsJ. Mayer, C. Harz (Homburg/DE), L. Sanchez (Granada/ES), G. Pereira (Baltimore, MD/US)S. R. Heras (Granada/ES), L. W. Ostrow (Baltimore, MD/US), J. RavitsR. Batra (San Diego, CA/US), J. L. García-Pérez (Granada/ES; Edinburgh/GB)J. L. Goodier (Baltimore, MD/US)

P 268The role of inhibitory ligands expressed on infected myeloid cells for the regulation of antiretroviral T cell responsesP. David, M. Drabczyk-Pluta, T. Werner, W. Bayer, U. Dittmer, G. Zelinskyy (Essen/DE)

P 269Milk leukocyte subpopulations and biochemical milk whey analysis during HCMV reactivationK. Lazar, K. Wistuba-Hamprecht, R. Goelz, G. Jahn, G. Pawelec, K. Hamprecht (Tubingen/DE)

P 270Development of small molecule inhibitors targeting TRAF2 protein binding to the LMP1 oncoprotein of Epstein-Barr virusF. Giehler (Munich/DE), K. Schorpp, S. Dornauer, K. Hadian (Munich/DE)J. Kirchmair (Hamburg/DE), A. Kieser (Munich/DE)

84

POSTER SESSION 2

P 271Pathogenicity and virulence determinants of recent German H7N7 viruses in different poultry speciesD. Scheibner, M. Gischke, A. Salaheldin, F. Winter, J. Veits, T. C. MettenleiterE. Abdelwhab (Greifswald – Isle of Riems/DE)

P 272The HIV-1 Antisense Protein (ASP) demonstrates nuclear localisation and modulates CD32a expressionB. Barbeau (Montreal/CA; Berlin/DE), Y. Xiao, Z. Liu, C. Cate, C. TorresillaE. Rassart (Montreal/CA)

P 273The non-structural protein NSs of Rift Valley fever virus – a novel model to study prion-like proteinsP. Léger, K. Richter, M. Stanifer, S. Boulant, F. Melchior, C. Nussbaum-KrammerP.-Y. Lozach (Heidelberg/DE)

P 274Tubulin-dependent delocalisation of cellular Na,K-ATPase during influenza A virus infectionI. Kuznetsova, C. Peteranderl (Giessen/DE), J. Schulze (Berlin/DE), S. Herold (Giessen/DE)T. Wolff (Berlin/DE), S. Pleschka (Giessen/DE)

P 275In vitro coinfection and replication of classical swine fever virus and porcine Circo virus Type 2 in PK15 cellsJ. Li (Nanjing/CN), N. Zhou (Hangzhou/CN), J. Gu (Nanjing/CN)J. Zhou (Nanjing, Hangzhou/CN)

P 276Maternal influenza A virus infection during early gestation causes very low fetal birth weight and delayed postnatal development in a murine pregnancy modelH. Jacobsen, K. Walendy-Gnirss, G. Gabriel (Hamburg/DE)

P 277Isolation and characterisation of human endogenous retroviruses K (HERV-K) from teratocarcinoma-derived cell lines GH and TERAV. Morozov, N. Bannert (Berlin/DE)

85

POSTER SESSION 2

P 278Tropism and spread of canine distemper virus and measles virus in the respiratory tract offerretsR. de Vries, D. Geers, B. M. Laksono (Rotterdam/NL), S. Nambulli (Boston, MA/US)A. Comvalius (Rotterdam/NL), L. J. Renninck (Boston, MA/US), T. Kuiken (Rotterdam/NL)P. Duprex (Boston, MA/US), R. L. de Swart (Rotterdam/NL)

P 279Characterisation of two recombinant human respiratory syncytial virus strains in immortalised cell lines and primary differentiated respiratory epithelial cellsL. Rijsbergen, A. de Jong (Rotterdam/NL), L. Rennick, S. Nambulli (Boston, MA/US)R. de Vries (Rotterdam/NL), P. Duprex (Boston, MA/US), R. de Swart (Rotterdam/NL)

P 280Immunomodulatory genes (ORF2 and UL43) of alphaherpesviruses play significant rolesin virus pathogenesis and transfer from infected PBMC to endothelial cellsP. Selvaraj, W. Azab (Berlin/DE)

P 281Ex vivo Morbilli virus infection of primary carnivore and primate brain tissue culturesD. Tran, B. M. Laksono, R. de Vries, G. Verjans, R. de Swart (Rotterdam/NL)

P 282Single point mutations in a positive-strand RNA virus prevent viral cytopathogenicity in atemperature dependent mannerO. Suckstorff (Hanover/DE), A. Pankraz (Ingelheim/DE), A. Postel, P. Becher (Hanover/DE)

P 283Release of immunomodulatory Ebola virus glycoprotein-containing microvesicles is suppressed by tetherinJ. Nehls (Tubingen, Munich/DE), R. Businger (Tubingen/DE), C. BrinkmannM. Hoffmann (Göttingen/DE), D. Kramer (Tubingen/DE), S. Pöhlmann (Göttingen/DE)M. Schindler (Tubingen/DE)

P 284Visualisation and characterisation of non-cytolytic clearance of LCMV-infected hepatocytes during persistent viral infectionP. Reuther, K. Martin (Basel/CH), D. Merkler (Geneva/CH), D. Pinschewer (Basel/CH)

86

POSTER SESSION 2

P 285Improved production of the secreted immunomodulatory E3/49K protein of species D Adeno viruses by codon optimisation and manipulation of sorting motifsH.-G. Burgert, L. Butler (Freiburg/DE), M. Windheim (Hanover/DE), Z. Ruzsics (Freiburg/DE)

P 286Seminal plasma inhibits human Cytomegalo virus infectionS. Lippold, F. Kruger, M. Harms, J. A. Muller, J. Munch, J. von Einem (Ulm/DE)

P 287Discriminating between alternative mechanisms of influenza virus control in human volunteersV. Ganusov, D. Le (Knoxville, TN/US)

P 288Active human complement reduced the titer of zika viruses via formation of the membrane-attack complexB. Schiela, S. Bernklau, D. Deutschmann (Innsbruck/AT), N. Thielens (Grenoble/FR)R. Wurzner, G. Weiss (Innsbruck/AT), K. Stiasny (Vienna/AT), E. Steinmann (Hanover/DE)H. Stoiber (Innsbruck/AT)

P 289Analysis of immune evasion gene expression during Cytomegalo virus latencyN. Lemmermann, A. Renzaho, M. Grießl, M. J. Reddehase (Mainz/DE)

P 290Modification of the spike gene attenuates highly virulent porcine epidemic Diarrhea virusin pigletsC. Kristen-Burmann (Giessen/DE), P. Rogger (Bern, Mittelhäusern/CH)R. Ehmann (Giessen/DE), J. Rappe (London/GB), H. Stalder (Bern, Mittelhäusern/CH)H. Posthaus, I. Veiga (Bern/CH), N. Ruggli (Bern, Mittelhäusern/CH)M. Ackermann (Zurich/CH), V. Thiel (Bern, Mittelhäusern/CH), G. Tekes (Giessen/DE)

P 291Natural diversity accelerates Morbillivirus reversion to virulenceM. Dörr, K. Pfeffermann, V. von Messling (Langen/DE)

P 292In vivo infection dynamics of Deformed Wing Virus (DWV) in honeybeesB. Lamp, B. Rebel-Bauder, A. Url (Vienna/AT), P. Plevka, K. Skubnik (Brno/CZ), K. BuczolichC. Riedel, D. Fink, S. Mandl, T. Rumenapf, K. Seitz (Vienn/AT)

87

POSTER SESSION 2

P 293Analysis of retroviral immunosuppressive domains expressed on the surface of human cellsD. Ivanusic, H. Pietsch, J. König, J. Denner (Berlin/DE)

P 294PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 productionM. Serrero (Hanover/DE), R. Planès, E. Bahraoui (Toulouse/FR)

P 295Myrcludex B and GLS4 interfere with formation of HBV covalently closed circular DNAB. Qu, B. Zehnder, T. Tu, Y. Ni, S. Urban (Heidelberg/DE)

P 296Restoration of glycoprotein Erns dimerisation via pseudoreversion partially restores virulence of classical swine fever virusA. Klingebeil, A. Tuzakov, G. Meyers (Greifswald – Isle of Riems/DE)

P 297Biodistribution of modified Vaccinia virus Ankara in embryonated chicken eggsA.-T. Lulf-Averhoff, A. Volz, S. Adam-Neumair, G. Sutter, M. C. Langenmayer (Munich/DE)

P 298Humanised mice to study human Adeno virus infection and transformationE. Rodriguez, W. H. Ip, J. Muller-Guhl, C. Muñoz-Fontela, T. Dobner (Hamburg/DE)

Viral transformation and oncogenesis

P 299A human endogenous retrovirus-encoded protease potentially processes numerous cellular proteinsG. Rigogliuso (Homburg/DE), M. L. Biniossek, O. Schilling (Freiburg/DE), E. MeeseJ. Mayer (Homburg/DE)

P 300FOXM1 and CKS1 – novel cellular targets of the HPV oncogenesS. Adrian, K. Hoppe-Seyler, F. Hoppe-Seyler (Heidelberg/DE)

P 301Hepatitis B virus upregulated lncRNA-HUR1 promotes cell proliferation and tumorigenesis by blocking p53 activityX. Ye (Beijing/CN)

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EPIDEMIOLOGIEHYGIENEMASSNAHMENANTIBIOTIKAPROPHYLAXE

13. ULMER SYMPOSIUMKRANKENHAUSINFEKTIONEN

27.–29. MÄRZ 2019©

Pet

er B

erge

r

www.krankenhausinfektionen-ulmer-symposium.de

TagungsleitungProf. Dr. med. Steffen StengerProf. Dr. med. Heike von Baum

P 302A quantitative assay to assess Marek’s disease virus genome integration in vitroL. D. Bertzbach, T. Vychodil, R. L. Previdelli, B. B. Kaufer (Berlin/DE)

P 303Impact of antiviral treatment on the development of HCC in HCV infected patientsD. Bojkova, S. Westhaus, L. Timmer, K. Lang, R. Bröring, S. Heinrichs, F. VondranS. Ciesek (Essen/DE)

Virus vectors and gene therapy

P 304Analysis of surface swab samples from genetic engineering installations for the presence ofHIV-1-based lentiviral and AAV-2 based vectorsA. Dinkelmeier, T. Stellberger, N. Köhler, M. Haase, M. Pavlovic, U. BuschA. Baiker (Oberschleissheim/DE)

P 305Novel Sendai virus vectors delivering HCMV antigens efficiently transduce monocyte-derived dendritic cells and potently restimulate T cell responses ex vivoR. Kiener, M. Fleischmann (Regensburg/DE), M. A. Wiegand (Martinsried/DE), C. SchweglerH. H. Niller, B. Asbach, R. Wagner (Regensburg/DE)

P 306New HCMV vaccine candidates based on an Adeno virus 64 vector exhibit broad cellular tropism and efficiently induce antigen expression in dendritic cellsR. Kiener, M. Fleischmann, C. Schwegler (Regensburg/DE), C. ThirionS. Schrödel (Martinsried/DE), B. Asbach, R. Wagner (Regensburg/DE) P 307Delivery of a multiplexed CRISPR/Cas9 system directed against hepatitis B virus cccDNAutilizing high-capacity adenoviral vectorM. Schiwon, E. Ehrke-Schulz (Witten/DE), A. Oswald (Munich/DE), T. Bergmann (Witten/DE)T. Michler, U. Protzer (Munich/DE), A. Ehrhardt (Witten/DE)

P 308Adenoviral vectors armed with HPV oncogene specific CRISPR/Cas9 for treatment of HPV related cancersE. Ehrke-Schulz, M. Schiwon, A. Ehrhardt (Witten/DE)

89

POSTER SESSION 2

EPIDEMIOLOGIEHYGIENEMASSNAHMENANTIBIOTIKAPROPHYLAXE

13. ULMER SYMPOSIUMKRANKENHAUSINFEKTIONEN

27.–29. MÄRZ 2019

© P

eter

Ber

ger

www.krankenhausinfektionen-ulmer-symposium.de

TagungsleitungProf. Dr. med. Steffen StengerProf. Dr. med. Heike von Baum

P 309Single vector transportation of CRISPR/Cas9 & Donor DNA for homology directed repairof canine hemophilia B reveals higher repair efficiencies than utilising two vectorsJ. Gao, T. Bergmann, M. Schiwon, E. Ehrke-Schulz, W. Zhang, A. Ehrhardt (Witten/DE)

P 310A constructed porcine Tescho virus with deleted highly conserved “RNNQIPQDF”epitope of VP1 has potential to serve as DIVA vectorT. Tsai (Taipei/TW), C.-Y. Chang (New Taipei/TW), F.-I. Wang (Taipei/TW)

P 311Ad 3.0 – high-throughput direct cloning and tagging of Adeno viruses empowers fast access to naturally emerging virusesW. Zhang (Witten/DE), E. Hage (Hanover/DE), A. Ehrhardt (Witten/DE), A. Heim (Hanover/DE)

P 312Immunogenicity and protective capacity of recombinant vaccinia virus MVA delivering influenza A virus M2 protein ectodomain (M2e) antigensA. Volz (Munich/DE), K. Roose (Ghent/BE), A. Freudenstein (Munich/DE)G. Rimmelzwaan (Rotterdam/NL), X. Saelens (Ghent/BE), G. Sutter (Munich/DE)

90

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Clinical virology

P 313Modeling and analysis of the probability and risk factors of HIV-1 low level viremiaM. Widera, D. Habermann, B. Budeus, D. Hoffmann, J. Verheyen, S. Esser (Essen/DE)

P 314Prevalence characteristics of influenza A viruses in children in Beijing during 13 surveillance seasons from 2004–2017F. Wang, Z. Runan, Q. Yuan, D. Jie, Z. Linqing, S. Yu, T. Run (Beijing/CN)

P 315Antigen-specific T-cell immunity against highly-pathogenic viruses in patients and healthypopulationW. J. Liu (Beijing/CN)

P 316HCMV-specific T-cell activation after HIG administration in pregnant women with HCMVprimary infectionM. Schampera, K. O. Kagan (Tubingen/DE), M. Germer (Dreieich/DE), G. JahnK. Hamprecht (Tubingen/DE)

P 317HCMV-specific neutralizing antibodies in amniotic fluid from women with primary HCMV-infectionL. Penka, K. Hamprecht, K. O. Kagan (Tubingen/DE)

P 318Impact of HBV genotype and mutations on HBV DNA and qHBsAg levels in patients withHBeAg-negative chronic HBV infectionL. Kuhnhenn (Frankfurt a. M., Langen/DE), B. Jiang (Langen/DE), J. Vermehren, V. KnopS. Susser, J. Dietz, S. Zeuzem (Frankfurt a. M./DE), C. Sarrazin (Wiesbaden, Frankfurt a. M./DE)E. Hildt (Langen, Giessen, Marburg/DE), K.-H. Peiffer (Frankfurt a. M., Langen/DE)

P 319Clinical outcome and viral genome variability of Hepatitis B Virus induced acute liver failureO. Anastasiou, M. Widera, S. Westhaus, L. Timmer, G. Gerken, A. Canbay, J. VerheyenS. Ciesek (Essen/DE)

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P 320Measles – not only a paediatric diseaseA. Herrmann, H. Guberina, F. Herbstreit, B. Ross, O. Witzke (Essen/DE)A. Mankertz (Berlin/DE), M. Fiedler (Essen/DE)

P 321Rota virus outbreak among adults in a university hospital, Germany, 2017S. Bierbaum, R. Babikir, D. Huzly, W. Ebner (Freiburg/DE), S. Niendorf (Berlin/DE), S. MaassenH. Grundmann, M. Panning (Freiburg/DE)

P 322Dysregulated signaling networks implicated in vascular aging of HIV+ subjectsJ. Thakar (Rochester, NY/US)

P 323Chronic cutaneous granulomas in a child with primary immunodeficiency associated withrubella Vaccine virus persistenceJ. Zimmermann, S. Böhm (Munich/DE), U. G. Liebert, M. Maier (Leipzig/DE), M. FlaigA. Eichinger, M. Albert, F. Hauck (Munich/DE)

P 324Travel-associated neurological disease after yellow fever vaccination terminated in a postmortem diagnosed HSV-1 encephalitisA. Osterman, V. Ruf, A. Giese (Munich/DE), C. Domingo (Berlin/DE), P. Eichhorn, S. ZangeK. Dimitriadis, H.-W. Pfister (Munich/DE), T. Thye, D. Tappe (Hamburg/DE)S. Böhm (Munich/DE)

P 325NKG2C deletion is a risk factor for human Cytomegalo virus-viremia and disease after lung transplantationH. Vietzen, K. Pollak, C. Honsig, P. Jaksch, E. Puchhammer-Stöckl (Vienna/AT)

P 326External quality assessment (EQA) of molecular multi-pathogen detection inviral respiratory infectionsO. Donoso Mantke (Berlin/DE), D. Montgomery, L. Paul (Glasgow/GB)A. Meijer (Bilthoven/NL), A. M. van Loon (Glasgow/GB), B. Niesters (Groningen/NL)

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P 327Whole genome sequencing of fowl Aviadeno virus A – a causative agent of gizzard erosion and ulceration, in adult laying hensA. Matczuk (Wroclaw/PL), J. Niczyporuk (Pulawy/PL), M. Kuczkowski (Wroclaw/PL)G. Wozniakowski (Pulawy/PL), M. Nowak, A. Wieliczko (Wroclaw/PL)

P 328Genetic diversity of the novel human Metapneumo virus A2c sublineage in Germany: occurrence of a 180 nt- and a 111 nt duplication in the G gene since 2014/15 and 2016/17B. Schweiger, B. Biere, J. Reiche (Berlin/DE)

P 329Metabolic shut down of CD4 T cell activity and function induced by antiretroviral therapyM. Korencak, E. Richter, E. Eilers, B. Schlutz, P. Juszczak, S. Esser, H. Streeck (Essen/DE)

P 330Chronic infection with novel GII.P24-GII.24 Noro virus after allogeneic hematopoietic stem cell transplantationC. Pietsch, N. Ennuschat, S. Härtel, U. G. Liebert (Leipzig/DE)

P 331BKV related nephropathy in a stem cell transplanted patient treated with a JAK inhibitorA. Plentz, M. Fante, B. Schmidt, E. Holler, D. Wolff (Regensburg/DE)

P 332Genetic polymorphisms and risk of hepatic steatosis in patients infected with Hepatitis C virusT. Vaz Gago Prata, D. de Souza Rodrigues da Silva, B. Peixoto DantasC. ManchieroC. Carmo Mazza, A. K. da Silva Nunes, E. Abdala, F. Mitiko TenganM. Cavalheiro Magri (Sao Paulo/BR)

P 333Impact of microsomal triglyceride transfer protein (MTTP) gene polymorphisms in lipid and insulin levels in patients chronically infected with Hepatitis C virusT. Vaz Gago Prata, B. Peixoto Dantas, C. Manchiero, C. Carmo Mazza, A. K. da Silva NunesE. Abdala, F. Mitiko Tengan, M. Cavalheiro Magri (Sao Paulo/BR)

93

POSTER SESSION 3

P 334A randomized controlled trial of lithium carbonate in individuals with HIV clade C-associated neurocognitive impairment – a phase IIb proof of principle studyC. Scheller, M. Gleich, N. Knetzger, C. Kronenthaler, K. Senf (Wurzburg/DE), E. DecloedtJ. Joska (Cape Town/ZA), S. Lovestone (Oxford/GB), G. Marteens (Cape Town/ZA)E. Koutsilieri (Wurzburg/DE)

P 335Inverse correlation between HIV viral load and neutralizing activity of plasma against theHIV HXB2 strain in patients with HIV infectionC. Kasang, N. Adil Gholam, R. Branner, L. Hartleb, N. Karguth, N. Knetzger, C. KronenthalerL. Lessel, T. Lukic, E. Lytton, L. Maag, S. Meyer, W. Rindt, C. Schwarz, K. Senf (Wurzburg/DE)S. Kalluvya, C. Majinge, G. Kongola (Mwanza/TZ), B. Weissbrich, D. Hofmann, A. StichH. Klinker, E. Koutsilieri, C. Scheller (Wurzburg/DE)

P 336Full genome characterisation of porcine Circo virus type 3 isolates reveals the existence of two distinct groups of virus strainsR. Fux, C. Söckler, E. K. Link, C. Renken (Munich/DE), R. Krejci (Libourne/FR), G. SutterM. Ritzmann, M. Eddicks (Munich/DE)

P 337Cytokine profiling of HCMV seropositive hematopoietic stem cell transplant recipients toidentify novel predictive biomarkersJ. Zischke, P. Varanasi, E. Mischak-Weissinger, C. Falk, A. Heim, T. F. SchulzT. Ganzenmuller, P. Kay-Fedorov (Hanover, Braunschweig/DE)

P 338Positive dengue IgG results in the Panbio dengue IgG ELISA in healthy travellers vaccinated against yellow fever indicate previous dengue infectionI. Schnabel, S. Schneitler, H. Trawinski, C. Lubbert, C. Jassoy (Leipzig/DE)

P 339Severe course of tick-borne encephalitis without detectable antibodies in three patientsafter rituximab treatmentP. Steininger (Erlangen/DE), C. Aepinus (Weiden/DE), A. Knöll, K. Korn (Erlangen/DE)

94

POSTER SESSION 3

Epidemiology and public health

P 342Epidemiologic aspects of viral diarrhoea among Nigerian childrenA. Efunshile, O. Ezeanosike (Abakaliki/NG), C. Pietsch, B. König, A. RodloffU. G. Liebert (Leipzig/DE)

P 343Molecular basis of the switch from avian to human receptor binding by influenza A virushemagglutinin H4H. Song, J. Qi (Beijing/CN), H. Xiao (Tianjin/CN), Y. Bi, Y. Shi (Beijing/CN)G. F. Gao (Beijing, Tianjin/CN)

P 344Detection and characterisation of Hepatitis-E-virus in urban and rural wastewater samplesS. Beyer, R. Szewzyk, H.-C. Selinka (Berlin/DE)

P 345Detection and typing of human enteric viruses in environmental watersF. Kubek, S. Schwarz, R. Szewzyk, H.-C. Selinka (Berlin/DE)

P 346Human Seoul virus infection in Indonesia imported to GermanyS. Weiss, J. Hofmann (Berlin/DE), M. Kuhns, A. Zinke, H. Heinsberger (Hamburg/DE)D. H. Kruger (Berlin/DE)

P 347The MARPHILI simulation – a scenario-based educational tool to sensitise high school students to infectious disease epidemicsC. Rohde, M. Fligge, S. Halwe, M. Kluver, A. Koehler, M. Ringel, M. Elvert, H. MullerJ. Westmeier, N. Biedenkopf, T. Freitag, B. Lamp, G. Schudt, J. Scholten, M. GollwitzerS. Becker (Marburg/DE)

P 348Year-long detection of Rhino virus on the nostrils of university students in Porto, PortugalA. F. Rodrigues, A. M. Santos, A. M. Ferreira, J. Cabeda (Porto/PT)

95

POSTER SESSION 3

P 349Hepatitis C virus genotype 4 in HIV-co-infected patients in SpainJ. Hillung, M. A. Bracho (Valencia/ES), M. Von Wichman (Donostialdea/ES)V. Asensi (Oviedo/ES), J. Mira (Sevilla/ES), R. Granados (Las Palmas/ES)M. Montes (Madrid/ES), L. Giner (Alicante/ES), C. Martin (Cáceres/ES)A. Rivero-Juarez (Córdoba/ES), F. Arnaiz de las Revillas (Santander/ES)J. Berenguer (Madrid/ES), C. Tural (Badalona/ES), F. Vera (Cartagena/ES)J. Gómez Sirvent (Santa Cruz/ES), J. Oteo (Rioja/ES), A. Aguilera (Santiago de Compostela/ES)J. Navarro (Barcelona/ES), R. Oropesa (Eivissa/ES), J. Moreno (Zaragoza/ES)E. Ortega González, F. González-Candelas (Valencia/ES)

P 350Defining outbreaks in the light of molecular epidemiologyS. Böttcher (Berlin/DE), A. Tröger, A. Riffer (Seelow/DE), S. Diedrich (Berlin/DE)

P 351Analysis of transmission clusters of HIV-1 in the comunidad Valenciana (Spain)J. Á. Patiño-Galindo, M. Torres-Puente, M. A. Bracho, I. Alastrué, A. Juan, D. NavarroM. J. Galindo, D. Ocete, E. Ortega, C. Gimeno (Valencia/ES), J. Belda (Alicante/ES)V. Domínguez, R. Moreno (Castellon/ES), F. González-Candelas (Valencia/ES)

P 352Screening of free-ranging Psittacula parakeet populations in central Europe for avian Borna viruses, Circo viruses and Polyoma virusesS. Kessler (Freiburg/DE), K. Heenemann (Leipzig/DE), T. Krause (Dusseldorf/DE)S. Twietmeyer (Schleiden-Gemund/DE), J. Fuchs (Paris/FR), M. Lierz (Giessen/DE)V. Corman (Berlin/DE), D. Rubbenstroth (Freiburg/DE)

Host cell factors and viral modulation 1+2

P 353Tula Orthohanta virus replication in human endothelial cells and macrophages is limited by an early induction of an antiviral innate immune responseD. Bourquain, C. Bodenstein, S. Schurer, L. Schaade (Berlin/DE)

P 354Mammalian haploid cell screen to identify host factors essential for rift valley fever virusS. Devignot, P. Schmerer (Giessen/DE), A. Leibbrandt, T. R. Burkhard, U. EllingJ. Penninger (Vienna/AT), F. Weber (Giessen/DE)

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POSTER SESSION 3

P 355Hepatitis E virus activates signal transducer and activator of transcription 3 to facilitatevirus replicationW. Wang (Rotterdam/NL), Y. Wang (Beijing/CN), C. Qu (Rotterdam/NL), S. WangJ. Zhao (Beijing/CN), M. Peppelenbosch, Q. Pan (Rotterdam/NL)

P 356Expression of ASFV proteins after infection of mammalian cultured cellsC. Keßler, J. H. Forth, G. Keil, T. C. Mettenleiter, S. BlomeA. Karger (Greifswald – Isle of Riems/DE)

P 357Identification of a conserved interface of HIV-1 and FIV Vifs with Cullin 5Q. Gu, Z. Zhang, C. Gertzen, D. Häussinger, H. Gohlke, C. Munk (Dusseldorf/DE)

P 358Perilipin-2 is critical for efficient lipoprotein and Hepatitis C virus particle productionS. Lassen, C. Gruttner, V. Nguyen-Dinh, E. Herker (Hamburg/DE)

P 359TRAIL induces apoptosis through downregulating DcR1 and DcR2 to sensitize HTNV-infected HUVECs and exhibits anti-HTNV activity in vivoQ.-Z. Chen, F. Luo, N. Li (Wuhan/CN), N. Zhu (Xianning/CN), S. Lu, G.-Y. Wang, C.-J. ZhongM.-R. Wang (Wuhan/CN), Y.-Z. Zhang (Beijing/CN), H.-R. Xiong, W. Hou (Wuhan/CN)

P 360Occludin as a host factor for PEDVA. Volland, B. A. Tews (Greifswald – Isle of Riems/DE)

P 361Single-Domain antibodies as tools to perturb and study RNA VirusesL. Hanke (Stockholm/SE), F. Schmidt (Bonn/DE), H. Ploegh (Boston, MA/US)

P 362Functional analysis of HSV-1 induced transcription read-throughL. Djakovic, L. Dölken (Wurzburg/DE)

P 363PLIN2 is a host factor involved in the alteration of lipid membrane structures and functional HCV particlesV. Nguyen-Dinh, S. Lassen, C. Gruttner, E. Herker (Hamburg/DE)

97

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P 364HIV-1, HIV-2 and SIV evolved independent mechanisms to decrease HLA-C cell surface levelsK. Hopfensperger, F. Kirchhoff, D. Sauter (Ulm/DE)

P 365Mouse Cytomegalo virus takes control of the of host signaling STRIPAK hubM. Dezeljin, I. Kutle (Hanover/DE), B. Bogdanow (Berlin/DE), T. Kubsch (Braunschweig/DE)K. Keyser (Hanover/DE), L. Wiebusch (Berlin/DE), L. Cicin-Šain (Hanover, Braunschweig/DE)M. Messerle (Hanover/DE)

P 366How the cellular protein G3BP promotes old world Alpha virus infectionB. Götte (Stockholm/SE), K. Hellström (Helsinki/FI), N. Kedersha (Boston, MA/US), B. ThaaM. Panas, L. Liu (Stockholm/SE), T. Ahola (Helsinki/FI), G. McInerney (Stockholm/SE)

P 367Preadaptation of SIVsmm may underlie Env-mediated counteraction of human tetherinin endemic and rare groups of HIV-2E. Heusinger, K. Deppe, C. Krapp (Ulm/DE), P. Sette, C. Apetrei (Pittsburgh, PA/US)F. Kirchhoff, D. Sauter (Ulm/DE)

P 368CRISPR-Cas-mediated knock-out of DNAJC14 (Jiv) verifies this chaperone as a pivotal hostfactor for RNA replication of Pesti virusesN. Tautz (Lubeck/DE), A. Postel (Hanover/DE), B. Bruhn (Lubeck/DE), P. Becher (Hanover/DE)O. Isken (Lubeck/DE)

P 369Human Cytomegalo virus inactivates SAMHD1 to promote viral genome replicationR. Businger (Tubingen/DE), J. Milbradt (Erlangen/DE), K. Hamprecht (Tubingen/DE)T. Gramberg (Erlangen/DE), M. Schindler (Tubingen/DE)

P 370Materials of the autophagic machinery localise to human cytomegaloviral assembly compartments and are packaged into virions and dense bodiesC. Zimmermann, S. Krauter, E. Sehn, U. Wolfrum, D. Strand, B. Plachter (Mainz/DE)

P 371The role of DUX4 in herpesviral infectionS. Walter (Erlangen/DE), M. Gack (Chicago, IL/US), A. Ensser, F. Full (Erlangen/DE)

98

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P 372It´s all about phosphorylation – regulatory interaction between the CDK ortholog pUL97of Cytomegalo virus and human cyclinsM. Steingruber, E. Socher, H. Sticht, L. Keller (Erlangen/DE), A. Kraut, S. Ferre, Y. CoutéM. Marschall (Grenoble/FR)

P 373Influence of cell-cell fusion on the unfolded protein response activation by measles virusglycoproteinsL. Zimmermann, L. Behner, J. Huther, C. Rohde, A. Maisner (Marburg/DE)

P 374The cellular nonsense-mediated mRNA decay and its role in HIV-1 infectionL. Walotka, N. Diehl, F. Hillebrand, H. Schaal (Dusseldorf/DE)

P 375Characterising the role of α-taxilin for the Hepatitis B virus entry processC. Spengler, J. Hoffmann (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

P 376TRIM28 deSUMOylation as a potential antiviral response during influenza virus infectionsN. Schmidt, P. Domingues, C. Patzina, F. Golebiowski, B. G. Hale (Zurich/CH)

P 377AP-1 signaling regulates LINE-1 retrotranspositionB. Volkmann, S. Wittmann, B. Biesinger, T. Gramberg (Erlangen/DE)

P 378Functional analysis of the influenza A virus M2 protein interaction with Na,K-ATPase in influenza pneumoniaJ. Schulze (Berlin/DE), C. Peteranderl, I. Kuznetsova, S. Pleschka, S. Herold (Giessen/DE)T. Wolff (Berlin/DE)

P 379Localisation to detergent-resistant membranes and HIV-1 core entry inhibition correlatewith HIV-1 restriction by SERINC5B. Schulte (Essen/DE), A. Selyutina, S. Opp (Bronx, NY/US), A. HerschhornJ. G. Sodroski (Boston, MA/US), M. Pizzato (Trento/IT), F. Diaz-Griffero (Bronx, NY/US)

P 380Analysis of the cellular response to HCMV dense bodiesI. Penner, A. Freiwald, M. Dejung, F. Butter, C. Zimmermann, B. Plachter (Mainz/DE)

99

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P 381Positive regulation of human-type influenza A virus polymerase activity by importin-α7 and ANP32A occurs by differential mechanismsS. Beck, J. Hoffmann, S. Thiele (Hamburg/DE), V. Sohst (Borstel/DE), F. Buck (Hamburg/DE)S. Stanelle-Bertram (Lubeck, Hamburg/DE), G. Gabriel (Hamburg, Lubeck/DE)

P 382Interaction of the cellular prolyl isomerase Pin1 with the cytomegaloviral DNA polymerasecomplexM. Schutz, M. Kießling, H. Sticht, J. Milbradt (Erlangen/DE)

P 383Identification of cellular and viral miRNA targets by BirA-Avi-CLIPB. Anand, F. Erhard, L. Dölken (Wurzburg/DE)

P 384Characterisation of mosquito proteins homologous to the human Flavi virus host factor AUF1A. Meyer, S.-E. Behrens, S. Friedrich (Halle a. d. S./DE)

P 385Mono-ADP-ribosylation as a modulator of Chikungunya virus infectionS. Krieg, C. Preisinger, B. Lippok, B. Luscher, P. Verheugd (Aachen/DE)

P 386The CHIKV nsP3 macrodomain manipulates the innate immune response by regulating intracellular mono-ADP-ribosylationS. Krieg, L. Eckei, M. Butepage, B. Lippok, A. R. Grimm (Aachen/DE), B. Kummerer (Bonn/DE)G. Rossetti (Aachen, Julich/DE), B. Luscher, P. Verheugd (Aachen/DE)

P 387The RNA remodeling activities of the Flavi virus host factor AUF1 are regulated by two RNA recognition motifs and one RGG/RG motifA. Meyer, L. Sänger, T. Schmidt, R. Golbik, S.-E. Behrens, S. Friedrich (Halle a. d. S./DE)

P 388Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous Retrovirus (PERV)H. Al-shehabi, U. Fiebig, J. Denner, N. Bannert, H. Hofmann (Berlin/DE)

100

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P 389Transcriptome analysis of trypsin-like serine proteases in the lower respiratory tract of mice and their putative role in proteolytic activation of influenza virusesA. Harbig, L. Bittel, N. Lange, M. Mernberger, A. Nist, E. Böttcher-Friebertshäuser (Marburg/DE)

P 390Protease specificity of influenza A virus H7N9 hemagglutinin with multibasic cleavage siteK. Hardes, R. Heindl, A. Harbig, A. Keils, T. SteinmetzerE. Böttcher-Friebertshäuser (Marburg/DE)

P 391Uncovering factors involved in human Herpes virus 6 (HHV-6) integration into host telomeresD. Wight, A. Sanyal (Berlin/DE), N. Wallaschek (Wurzburg/DE), C. ZimmermannB. Kaufer (Berlin/DE)

P 392Decoding genotype-phenotype associations with genphenS. Kitanovski, K. Lang, D. Hoffmann (Essen/DE)

P 393Role of TMPRSS2 in proteolytic activation of influenza A virus hemagglutinin with monobasic cleavage site in human airway epithelial cellsH. Limburg, D. Bestle, H. Janga, L. Schulte (Marburg/DE), H. MoultonD. A. Stein (Corvallis, OR/US), E. Friebertshäuser (Marburg/DE)

P 394Characterisation of the hemagglutinin cleaving proteases TMPRSS2 and matriptase as potential targets for influenza treatmentA. Keils (Marburg/DE), V. Magdolen (Munich/DE), E. Böttcher-FriebertshäuserT. Steinmetzer (Marburg/DE)

P 395Identification of host factors involved in KSHV latency establishment using a CRISPR/Cas9screening approachJ. Fröhlich (Hamburg/DE)

P 396RNA processing bodies are reduced in number in alphavirus infected cellsL. Liu, E. Weiss, M. Panas, S. Sellberg, B. Thaa, G. McInerney (Solna/SE)

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P 397Engineering an EGFR-directed IgA2 antibody for improved myeloid effector cell engagementin vivoS. Lohse (Homburg/DE), D. Kolarich (Potsdam/DE), J. Leusen (Utrecht/NL), T. Valerius (Kiel/DE)

P 398Small molecule interactors of SAMHD1 – targeting a restriction factor of HIV infectionP. R. Wratil, S. Schneider (Munich/DE), A. Oder, M. Neuenschwander (Berlin/DE)S. Bauernfried (Munich/DE), J. Cinatl Jr. (Frankfurt a. M./DE), V. Hornung (Munich/DE)J. von Kries (Berlin/DE), O. T. Keppler (Munich/DE)

P 399ABCE1 is an essential paramyxo- and pneumoviridae host factorK. Pfeffermann (Langen/DE), D. E. Anderson (Singapore/SG), S. Y. Kim (Durham, NC/US)B. Sawatsky (Langen/DE), P. Duprex (Boston, MA/US)M. A. Garcia-Blanco (Galveston, TX/US, Durham, NC/US; Singapore/SG)V. von Messling (Singapore/SG; Langen/DE; Laval/CA)

P 400Polycomb repressive complex 1 and 2 contribute to HCMV DNA replication independentof their enzymatic activityA. Svrlanska (Erlangen/DE), T. Stamminger (Ulm/DE), N. Reuter (Erlangen/DE)

P 401Influence of nuclear localisation sites in Hendra virus matrix protein on interaction withANP32B and virus like particle formationM. Günther, S. Finke (Greifswald – Isle of Riems/DE)

P 402A study of factors determining the susceptibility of melanoma cells to infection with Leningrad-16-derived vaccine strain of oncolytic measles virusY. Ammour, O. Ryabaya, T. Nasedkina, V. Zverev (Moscow/RU)

P 403REDD1 and mTORC1 regulate measles virus replication in vero and primary human peripheral blood mononuclear cellsV. Tiwarekar, J. Wohlfahrt, M. Fehrholz, J. Schneider-Schaulies (Wurzburg/DE)

P 404Temporary reprogramming of activation-inert latently infected host cells to trigger efficient HIV-1 reactivationA. Duverger, F. Wagner, M. Zhang, B. Shi, R. Cron, H. Hu, O. Kutsch (Birmingham, AL/US)

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P 405Ca2+ modulatory gene products of mCMV activate mast cellsJ. K. Schmiedeke, A.-K. Hartmann, M. J. Reddehase, M. Stassen, N. Lemmermann (Mainz/DE)

P 406A genome-wide CRISPR screen to identify cellular factors regulating Rev-dependent geneexpression of HIV-1H. Xiao (Erlangen/DE), B. Grewe (Bochum/DE), A. Ensser, A. Beatriz VillelaK. Überla (Erlangen/DE)

P 407Glycoprotein G of HSV-2 facilitates infection of neurons through the neurite endK. Kropp, B. Ritter, S. Luther, S. Srivaratharajan, S. Zhu, A. Dhingra (Hanover/DE)A. Domingo (Madrid/ES), J. Czechowicz, C. Henning-Nagel (Hamburg/DE)B. Sodeik (Hanover/DE), A. Alcami (Madrid/ES), A. Viejo-Borbolla (Hanover/DE)

P 408Avian influenza A virus inhibits activation of human PKR activityC. Mache, M. Budt, T. Wolff (Berlin/DE)

P 409A novel, small linear interaction motif in HCMV-pUL21a is required for destabilisation of APC/C subunitsI. Husic, I. Gruska, B. Vetter, C. Hagemeier, L. Wiebusch (Berlin/DE)

P 410Alternative mRNA polyadenylation modulates influenza A virus induced innate immuneresponseV. Bergant, A. Meiler, P. Hubel (Munich/DE), D. Schnepf (Freiburg/DE)R. Dijkman (Bern/CH), P. Stäheli, G. Kochs (Freiburg/DE), A. Pichlmair (Munich/DE)

P 411The interferon-stimulated gene product oligoadenylate synthetase-like protein enhancesreplication of Kaposi’s sarcoma-associated Herpes virus (KSHV) and interacts with the SHV ORF20 proteinK. A. Bussey, U. Lau (Braunschweig/DE), S. Schumann (Leeds/GB), A. Gallo (Hamburg/DE)L. Osbelt, M. Stempel, C. Arnold, J. Wissing (Braunschweig/DE), H. H. GadR. Hartmann (Aarhus/DK), W. Brune (Hamburg/DE), L. Jänsch (Braunschweig/DE)A. Whitehouse (Leeds/GB), M. M. Brinkmann (Braunschweig/DE)

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P 412Exploring restriction of HIV-1 by endogenous SERINC5 proteinV. Passos (Hanover/DE), T. Zillinger (Bonn/DE), N. Casartelli (Paris/FR), S. XuA. Malassa (Hanover/DE), H. Schilling (Bonn/DE), S. Franz (Hanover/DE)O. Schwartz (Paris/FR), W. Barchet (Bonn/DE), C. Goffinet (Hanover/DE)

P 413Rat Cytomegalo virus γ-chemokine vXCL1 interacts with XCR1+ dendritic cellsJ. C. Madela, A. Bauer, H. Geyer, S. Voigt (Berlin/DE)

P 414Rubella virus infection induces activation of pro-apoptotic NF-κB signalling pathway to ensure viral replication in A549 cellsP. Rennert, H. Geyer, A. Mankertz, N. Friedrich (Berlin/DE)

P 415The genetic polymorphism of the PD-1 molecule among patients with HIV-1 infection andits impact on suceptibility to AIDSB. Hanâ, K. Anass, Z. Imane, B. Meryem, B. Rajaâ, M. E. F. Kamal, E. SayehW. Lahcen (Casablanca/MA)

P 416Investigation of the relevance of processing and secretion of glycoprotein G from herpessimplex virus type 2S. Srivaratharajan, S. A. Krooss, P. Yu, B. Ritter, K. Kropp, J. BohneA. Viejo-Borbolla (Hanover/DE)

P 417HCMV US11 two-headed attack of HLA-A – distinct domains target the HLA-A supertypes A2 and A3C. Zimmermann (Freiburg, Berlin/DE), A. Hildenbrand, M. SchwarzmullerH. Hengel (Freiburg/DE), F. Momburg (Heidelberg/DE), A. Halenius (Freiburg/DE)

P 418SERINC’s antiviral activity and antagonism are highly conservedP. Pereira (Munich/DE; Vairão, Porto/PT; Frankfurt a. M., Munich/DE)J. Abrantes (Vairão/PT), V. Pierini (Heidelberg/DE), M. Pizzato (Trento/IT)P. J. Esteves (Vairão, Porto, Gandra/PT), O. T. Keppler (Munich, Frankfurt a. M./DE)O. Fackler (Heidelberg/DE), H.-M. Baldauf (Munich, Frankfurt a. M./DE)

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P 419Stop-and-go in translational regulation – modeling the oscillating cellular stress responseto Hepatitis C virus infectionP. Klein, S. Kallenberger, H. Roth, J. Ales, Y. Qiang, S. Seitz, O. Oleksiuk, B. Di Ventura, R. EilsK. Rohr, R. Bartenschlager, F. Hamprecht, O. Fackler, A. Ruggieri (Heidelberg/DE)

P 420A CRISPR-Cas9 screen for cellular proteins involved in flavivirus replicationK. Danskog, A. Upadhyay (Umeå/SE), P. Hubel, A. Pichlmair (Martinsried-Munich/DE)A. K. Verby (Umeå/SE)

P 421Galectins and the antiviral immune response to enveloped virusesM. J. Raftery (Berlin/DE), V. Atanov (Moscow/RU), D. H. Kruger, B. Klempa (Berlin/DE)N. Bovin (Moscow/RU), G. Schönrich (Berlin/DE)

Vaccines

P 422Development of a novel poxvirus-based therapeutic cancer vaccine for the treatment of papillomavirus-induced tumorsM. Schneider, R. Amann, T. Feger, A. Yigitliler, J. Xi, H.-G. Rammensee, F. StubenrauchT. Iftner (Tubingen/DE)

P 423Clinical trials of the IMMUNIS-PED-M® in KoreaH.-J. Shin (Taejon/KR)

P 424Therapeutic hepatitis B vaccination followed by CpG-application achieves immune control of persistent HBV infection in murine modelsA. Kosinska, N. Kallin, A. Moeed, J. Hasreiter, J. Su (Munich/DE), M.-L. Michel (Paris/FR)P. Knolle, U. Protzer (Munich/DE)

P 425Development of MERS Corona virus subunit vaccine and optimization of antigen expression using CHO cellsE. Ryu, G. Wi, S. Kim, H. Jang (Yesan/KR)

P 426Results of a safety pooled analysis of an adjuvanted herpes zoster subunit vaccine in more than 14,500 Participants aged 50 Years or olderJ. Hain (Munich/DE)

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P 427Development of a new approach for therapeutic vaccination against chronic HBV infectionT. Zahn, S. Akhras, E. Hildt (Langen/DE)

P 428Double-attenuated influenza a live vaccine in swineS. Mamerow, R. Scheffter, O. Stech, U. Blohm, T. Schwaiger, C. Schröder, R. UlrichJ. Schinköthe, M. Beer, T. C. Mettenleiter, J. Stech (Greifswald – Isle of Riems/DE)

P 429Generation and biochemical characterisation of HIV-1 envelope immunogens with increased stability and affinity to broadly neutralising antibodiesC. Schmalzl, V. Graßmann, H. Hierl, M. Glögl, A. Kliche, B. Asbach, D. PeterhoffR. Wagner (Regensburg/DE)

P 430Development of the Hz/SU zoster subunit vaccine and implications for herpes zoster preventionJ. Hain (Munich/DE), C. Clarke, N. Lecrenier, R. Colindres, L. Oostvogels (Wavre/BE)

P 431A cell line for characterisation, screening and production of well-folded Furin dependentvirus membrane fusion proteins – HIV envelope exampleD. Peterhoff, D. Fiegle, L. Stabenau, B. Zimmer, R. Wagner (Regensburg/DE)

P 432Engineering of HIV-1 clade C envelope trimers with increased stability and optimal antigenic properties as vaccine candidatesA. Hauser, D. Peterhoff, F. Schönfelder, K. Heyn, R. Merkl, I. Ganser (Regensburg/DE)W. Weissenhorn (Grenoble/FR), R. Sanders (Amsterdam/NL), R. Wagner (Regensburg/DE)

P 433Full protection against influenza A in a one shot scheme with yeast subunit vaccinesM. Gebauer, H. Hurlimann, M. Behrens, K. Breunig (Halle a. d. S./DE)T. Wolff (Berlin/DE), S.-E. Behrens (Halle a. d. S./DE)

P 434Recombinant MVA vaccines impair latent murine gammaherpesvirus infectionB. Samreen (Dusseldorf/DE; Stockholm/SE), H. Adler (Berlin, Munich/DE)K. Tischer (Berlin/DE), I. Drexler (Dusseldorf/DE)

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P 435Determining correlates of protection of a MVA-based vaccine against Ebola virus in a mouse modelA. Kupke (Marburg/DE), A. Volz (Munich/DE), E. Dietzel, J. Schmidt, H. Shams-EldinL. Sauerhering, M. Gellhorn Serra (Marburg/DE), C. Herden (Giessen/DE), M. EickmannS. Becker (Marburg/DE), G. Sutter (Munich/DE)

P 437Optimisation of a rescue protocol for the generation of recombinant vesicular stomatitis virus vaccine candidates against Filo virusesJ. Westmeier, S. Becker, O. Dolnik (Marburg/DE)

P 438Broadly neutralising nanobodies from env-immunized drome-daries for prophylactic lactobacillus approaches against hiv-1 HIV-1S. Kalusche, K. Koch (Frankfurt a. M./DE), U. Wernery (Dubai/AE)F. Koch-Nolte (Hamburg/DE), J. Torres, R. Stanfield, I. Wilson, A. Ward (La Jolla, CA/US)H. Marcotte (Stockholm/SE), F. Klein (Cologne/DE), U. Dietrich (Frankfurt a. M./DE)

P 439Windows of opportunity for Ebola virus infection vaccinationV. K. Nguyen, E. A. Hernandez-Vargas (Frankfurt a. M./DE)

P 440Characterisation of multifunctional immune responses induced by a MERS-CoV vaccine based on the recombinant MV vaccine platformB. Bodmer, A. Fiedler, C. Nurnberger, M. Muhlebach (Langen/DE)

P 441Checkpoint inhibitors as adjuvants for viral vaccinesP. Tannig, V. Temchura, D. Lapuente, K. Überla, M. Tenbusch (Erlangen/DE)

P 442Studying HIV-1 Envelope-antibody interactions under close-to-native conditions using MicroScale ThermophoresisB. Zimmer, C. Kuttenberger, T. Fischer, S. Schmidt, V. Grassmann, D. Peterhoff, T. SchubertR. Wagner (Regensburg/DE)

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P 443Vaccination with recombinant modified vaccinia virus Ankara (MVA) protects against parrot Borna virus infection and proventicular dilatation disease in psittacinesI. Rall (Freiburg, Tubingen/DE), C. Herden (Giessen/DE), R. Amann (Tubingen/DE)S. Malberg (Giessen/DE), D. Rubbenstroth (Freiburg/DE)

P 444Vaccination with HBsAg-expressing MCMV vectors raises protective immune responses against the Hepatitis B virus in the hydrodynamic injection mouse modelM. Ruckborn (Essen/DE), H. Huang (Wuhan/CN), V. T. K. Le-Trilling (Essen/DE)J. Liu (Wuhan/CN), M. Trilling (Essen/DE)

P 445Activation of transgenic T and B cells by liposomal vaccines encapsulating heterologous Thelper cell epitopesD. Damm (Erlangen/DE), E. Suleiman, D. Katinger (Klosterneuburg/AT)H. Elsayed (Erlangen/DE), A. Kolenbrander (Bochum/DE), J. Ingale, R. WyattD. Nemazee (La Jolla, CA/US), V. Temchura, K. Überla (Erlangen/DE)

P 446Biodistribution of the vaccine candidate MVA-MERS-S in mice following single dose intramuscular inoculationM. C. Langenmayer, A.-T. Lulf-Averhoff, S. Adam-Neumair, R. Fux, G. SutterA. Volz (Munich/DE)

P 447E3L and F1L gene functions modulate the protective capacity of modified vaccina virus Ankara immunisation in murine model of human smallpoxA. Volz, S. Jany, A. Freudenstein (Munich/DE), M. Lantermann, H. Ludwig (Langen/DE)G. Sutter (Munich/DE)

P 448Characterisation of CD8 T cell responses recognising the MERS Corona virus nucleocapsid protein using MVA vector immunisation in miceS. Veit, S. Jany, G. Sutter, A. Volz (Munich/DE)

P 449Immunisation with DNA vaccines encoding different variants of human respiratory syncytial virus glycoproteinsL. Issmail, T. Grunwald, L. Bayer (Leipzig/DE)

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SPONSORS

We would like to give our sincere thanks to the following sponsors:

Gold sponsorsQIAGEN GmbH (Hilden/DE)

Zymo Research GmbH (Freiburg/DE)

Silver sponsorsAbbott GmbH & Co. KG (Wiesbaden/DE)

Luminex B. V. (MV’s-Hertogenbosch/NL)

Cepheid GmbH (Frankfurt a. M./DE)

Bronze sponsorsINTEGRA Biosciences Deutschland GmbH (Biebertal/DE)

Labotect Labor-Technik-Göttingen GmbH (Rosdorf/DE)

Takara Bio Europe SAS (St-Germain-en-Laye/FR)

Vela Diagnostics Germany GmbH (Hamburg/DE)

Further sponsorsantibodies-online GmbH (Aachen/DE)

CAISTER ACADEMIC PRESS (Poole/GB)

DiaSorin Deutschland GmbH (Dietzenbach/DE)

GeneTex, Inc. (Irvine, CA/US)

genomics-online GmbH (Aachen/DE)

Gilson International BV Germany (Limburg/DE)

QCMD (Berlin/DE)

State at printing.

29th Annual Meeting ofthe Society for VirologyGesellschaft für Virologie e. V.

und

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.

20–23 March 2019 Düsseldorf • Germany

Save the Datewww.virology-meeting.de

© davis l Fotolia.com

109

GENERAL INFORMATION29th Annual Meeting ofthe Society for VirologyGesellschaft für Virologie e. V.

und

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.

20–23 March 2019 Düsseldorf • Germany

Save the Datewww.virology-meeting.de

© davis l Fotolia.com

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INDUSTRIAL EXHIBITION

The following exhibitors are looking forward to welcoming you at their booth:

Company Booth no.

Abbott GmbH & Co. KG (Wiesbaden/DE) 2Advanced Analytical GmbH (Heidelberg/DE) 25altona Diagnostics GmbH (Hamburg/DE) 14Analytik Jena AG (Jena/DE) 27Becton Dickinson GmbH (Heidelberg/DE) 11Bio-Sys GmbH (Karben/DE) 22bioMérieux Deutschland GmbH (Nurtingen/DE) 18BIOMOL GmbH (Hamburg/DE) 10BIOZOL Diagnostics Vertrieb GmbH (Eching/DE) 16Cepheid GmbH (Frankfurt a. M./DE) 3Cyagen Biosciences and VectorBuilder (Neu-Isenburg/DE) 28Dunn Labortechnik GmbH (Asbach/DE) 17Hain Lifescience GmbH (Wiesbaden/DE) 23Hologic Deutschland GmbH (Wiesbaden/DE) 19ibs | tecnomara GmbH (Fernwald/DE) 21INTEGRA Biosciences Deutschland GmbH (Biebertal/DE) 8INSTAND e. V. (Dusseldorf/DE) 15Labotect Labor-Technik-Göttingen GmbH (Rosdorf/DE) 29Li-COR Biosciences GmbH (Bad Homburg/DE) 13Luminex B.V. (MV’s-Hertogenbosch/NL) 4Merck (Darmstadt/DE) 24New England BioLabs GmbH (Frankfurt a. M./DE) 12OLS OMNI Life Science GmbH & Co. KG (Bremen/DE) 26QIAGEN GmbH (Hilden/DE) 5Sarstedt AG & Co. KG (Nuembrecht/DE) 20Siemens Healthcare Diagnostics GmbH (Eschborn/DE) 9Takara Bio Europe SAS (St-Germain-en-Laye/FR) 7Vela Diagnostics Germany GmbH (Hamburg/DE) 6Zymo Research Europe GmbH (Freiburg/DE) 1

State at printing.

http://www.abbott.com/

http://www.altona-diagnostics.com/

http://www.biosys.de/

http://www.biomerieux.com/

https://www.biomol.de/

http://www.biozol.de/

http://www.cepheid.com/

https://www.licor.com/

http://www.neb-online.de/

http://www.zymoresearch.de/

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2

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5

1

4

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8

25

910

11

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14 16

17

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27

22 23 24

26

First floor

Ground floor

Entrance

Entrance

28

29 13

Posters Industrial exhibition Speakers´ ready room

Catering Check-in/Self check-in

15

Lecture hall 2

Lecture hall 3

Lecture hall 1

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FLOOR PLAN

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MEDIA COOPERATIONS AND SCIENTIFIC SPONSORS

We would like to thank the following media partners and scientific sponsors for their great support:

Media cooperationsS. Karger AG (Basel/CH)Intervirology

Springer Nature (Vienna/AT) European Journal of Clinical Microbiology & Infectious DiseasesVirus GenesArchives of Virology

Buro-, Verlags- und Tagungsservice Dagmar Strebel (Karlsruhe/DE)Der Mikrobiologe

TRILLIUM GmbH (Grafrath/DE)Trillium Immunologie Trillium Diagnostik

Shanghai Springer Information Consulting Services Co., Ltd. (Beijing/CN)Virologica Sinica

Scientific sponsorsGesellschaft fur Virologie e. V.(GfV, Society for Virology)

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.(DVV, German Association for the Control of Virus Diseases)

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GENERAL INFORMATION

AbstractsAll abstracts will be provided as a pdf-file on a memory stick. You will receive one at the booth from Cepheid GmbH, booth number 3. The pdf-file will also be available on the website at www.virology-meeting.de.

AwardsAll posters will be rated according to scientific basis and visual appearance. There will be awards for the three best posters.

CateringTea, coffee, refreshments and snacks will be provided during the official programme breaks and poster sessions within the industrial exhibition areas (please refer to page 111).

Education credits and certificationThe certification of the conference for scientists is applied by the “Medical Cham-ber of Bavaria” (Landesärztekammer Bayern) and especially for veterinarians by the “Medical Chamber of Veterinary” (Bundestierärztekammer, Akademie fur tierärztliche Fortbildung). For certification all attendants are required to sign the certification list near the Check-In daily.

Credit points “Medical Chamber of Bavaria”:14 March Category B 3 Points15 March Category B 3 Points16 March Category B 3 Points17 March Category B 3 Points

Credit hours “Medical Chamber of Veterinary”: 14–17 March, 23 hours

Certificate of attendanceCertificates of attendance may be picked up at the certification point near the Check-In.

GTC

General terms and conditionsPlease find all details on our website at www.virology-meeting.de.

InternetA wireless internet access (wifi) is available in the main building. Please use the BayernWLAN, no password is needed.

LanguageThe conference language is English. No simultaneous translation will be provided.

http://www.virology-meeting.de


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GENERAL INFORMATION

Opening hours Wednesday Thursday Friday Saturday

Industrial exhibition 11.30–21.30 10.00–17.30 10.00–19.30 08.30–10.45Poster exhibition 14.30–21.30 08.30–19.30 08.30–19.30 –Check-In 11.00–19.00 07.30–18.30 08.00–18.30 08.30–12.45 Speakers’ ready room 11.00–18.00 07.30–17.30 08.00–17.30 08.30–12.00

Registration fees

from 26 Jan on-siteRegular (GfV-Member) 200 EUR 220 EURRegular (Non-Member) 250 EUR 280 EURDay ticket 120 EUR 130 EURStudent* (GfV-Member) 90 EUR 100 EURStudent* (Non-Member) 150 EUR 170 EUR

Social evening (16 March)Regular 40 EURStudent* 20 EURAccompanying Person 40 EUR* Confirmation of status is required.

Travel within Wurzburg • public transportPublic Transport Ticket in Wurzburg 15,20 EURThe ticket is valid for 4 days (14–17 March) and can be collected on-site at the check-in.

For more information about the public transport in Wurzburg, please refer to the VVM Verkehrsunternehmens-Verbund Mainfranken GmbH via www.vvm-info.de or download the VMM-App in your App store.

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SOCIAL PROGRAMME

Get-Together • Wednesday, 14 MarchThe first evening of the congress has become a nice tradi-tion amidst the setting of the industrial exhibition. Join our Get-Together with some fingerfood and a glass of wine and meet both familiar and new colleagues. At the same time, you can visit the “Poster session 1” and meet the presenting authors at their posters for inspiring discussion.

The Get-Together is included in the registration fee.

Date Wednesday, 14 MarchTime 19.00–21.30Location Julius-Maximilians-Universität Wurzburg

Hörsaal-Gebäude Z6Am Hubland • 97074 Wurzburg (DE)

Social evening • Friday, 16 MarchWe would like to invite you to our social evening, which will be held at the “Mensa“ of the Julius-Maximilians-Universität Wurzburg. Be pleasantly surprised by the outstanding acoustic and visual entertainment highlight of the evening, the par-tyband “Daniel Ligges & Band”, which will certainly set the tone. They perform again to play the best songs from current chart hits and give you a fantastic evening.

Date Friday, 16 MarchTime 20.00–01.00Location Mensasaal Studentenhaus

Am Studentenhaus • 97072 Wurzburg (DE)Fee Regular 40 EUR Student* 20 EUR Accompanying Person 40 EUR * Confirmation of status is required.

© Rawpixel.com l Fotolia.com

© Daniel Ligges & Band

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INDEX OF INVITED SPEAKERS, ABSTRACT AUTHORS AND CHAIR PERSONS

AAlbanese, M. P 78Abdala, E. P 332 P 333, P 23Abdelwhab, E. P 271 P 66, P 51Abere, B. OP 89Aberle, J. P 06, P 36, P 171Aberle, S. P 06, P 36, P 171Aberle, S. W. OP 138Abicht, J.-M. P 56Ablasser, A. IL 06Abok, I. OP 121Abrantes, J. P 418Ackermann, J. P 87Ackermann, M. P 290Adam, A. P 33Adam-Neumair, S. P 446 P 297Adams, O. OP 135 P 164, P 20Adil Gholam, N. P 335Adler, B. P 126Adler, H. P 434, OP 129Adrian, S. P 300Aebischer, A. OP 63Aepinus, C. P 339Aguilera, A. P 349Ahmeti, S. OP 13Ahola, T. P 366Akalin, A. OP 95Akgul, B. OP 81Akhras, S. P 427, P 07, P 44Akimkin, V. P 58Alastrué, I. P 351Albert, M. P 323Albrecht, D. P 91Alcami, A. P 407Alemayehu, A. E. P 15Ales, J. OP 93, P 419Alexandrov, A. OP 133 OP 18Alexyuk, M. P 218Alexyuk, P. P 218Ali, M. P 48Ali, W. P 53Al-Mahtab, M. P 174Alquezar-Planas, D. OP 36Alsarraj, S. P 53Al-Shehabi, H. P 388Alves, M. A. OP 86Amann, R. P 422, P 443Ammour, Y. P 402Anand, B. P 383Anass, K. P 415Anastasiou, O. P 319Anderson, D. E. P 399Anderson, F. P 250, P 228Andrée, M. P 20Angelova, A. OP 72

Anhlan, D. P 265Antos, A. P 46Apetrei, C. P 367Arabyan, E. P 193Arboleda, J. P 79Arnaiz de las Revillas, F. P 349Arnold, C. P 411Arora, P. P 208Asbach, B. P 429, P 149 P 12, P 305, P 306Asensi, V. P 349Asil, R. P 53Assis, M. P 27Atanov, V. P 421Attah, C. OP 121Audebert, F. P 133Auste, B. OP 125Avdic, S. P 68Ay, B. OP 17Ayginin, A. P 211Azab, W. P 280Aziz, M. P 232

BBabikir, R. P 321Bächlein, C. OP 38Bäcker, E. P 165Bader, M. P 228Baechlein, C. P 35Bähr, A. P 56, P 57Bahraoui, E. P 294Baiker, A. P 304, P 17Baldauf, H.-M. P 418Balkema-Buschmann, A. P 24, P 62Ballal, A. P 53Banas, B. P 04, OP 16Banas, M. OP 16Bańbura, M. W. P 142, P 88Banki, Z. P 92, P 167Bankwitz, D. OP 64Bank-Wolf, B. P 73Bannert, N. P 145, P 120 OP 123, P 89, P 388 P 277, P 226, P 10, P 15Barabas, S. P 03 P 04, OP 16, P 12Barbeau, B. P 272, P 120Barchet, W. P 412, P 109Barf, M. OP 72Barman, S. P 43Baron, A. L. OP 38Barr, J. P 24Bartels, H. P 58Bartenschlager, R. P 75 P 49, P 105, P 108, P 419Bartfeld, S. P 234, P 91Bartmeyer, B. P 10

Bartsch, T. P 203Bąska, P. P 142Batra, R. P 267Batzilla, J. P 04Bauer, Ag. P 413Bauer, Am. OP 68Bauer, S. P 128Bauer, T. OP 08Bauerfeind, R. OP 76 P 250, P 228Bäuerle, T. P 254Bauernfried, S. P 398, P 78Baumann, J. P 124Bayer, C. OP 57Bayer, L. OP 47 OP 105, P 449Bayer, N. OP 73Bayer, W. P 268 OP 58, OP 69, P 168Bazinet, M. P 174Bdeir, N. P 208Beatriz Villela, A. P 406Beauclair, G. P 180 OP 89, P 204Becher, P. P 368, P 71, P 35 OP 38, P 08, P 282, P 46Beck, S. P 381Becker, Ja. OP 46Becker, Ju. P 05Becker, N. P 31Becker, S. C. P 110Becker, S. P 73 P 435, OP 115, P 437 P 52, P 347, P 103, P 19Becker, T. P 249Beer, M. OP 63, P 428, OP 34, P 39, OP 54 OP 02, P 111Behner, L. P 223 P 373, P 103Behrendt, P. P 186 P 235, OP 64Behrendt, R. P 115Behrens, M. P 433Behrens, S.-E. P 433 OP 39, OP 96, P 384, P 387Beicht, J. P 124Beierfuß, A. P 172Bejarano, D. OP 98Belda, J. P 351Belinchon, F. P 151Beling, A. P 101Bello, G. P 27Belsham, G. J. P 231Bender, S. P 105Bendfeldt, H. P 03, P 04Benjelloun, S. P 114Berenguer, J. P 349Berezin, V. P 218

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El Dessouky, A. P 30El Habazi, A. P 114Eléouët, J.-F. P 207Elgner, F. P 181, P 07, P 44Elisseeff, X. P 120Ellerbrok, H. OP 94Elling, U. P 354Elsayed, H. OP 107, P 445Elsheredy, A. P 197Elshesheny, R. P 43El-Shesheny, R. P 48Elsner, C. P 109Elvert, M. P 41, P 347Elzayat, M. T. P 63, P 64Emmerich, P. OP 13Engelhart, S. P 81Engelmann, M. P 186 P 108Engler, O. OP 86Ennker, K. S. P 14Ennuschat, N. P 330Ensser, A. OP 80, P 229 P 371, P 67, OP 03, P 406Erhard, F. OP 113 OP 19, P 383, P 219Erkelenz, S. P 176Erster, O. P 37, P 42Eshetu, A. P 10Essbauer, S. P 34 P 39, P 248Esser, S. P 313 OP 48, P 329Esteves, P. J. P 418Estrada Girona, G. OP 118Eweda, S. P 232Ezeanosike, O. P 342Ezzikouri, S. P 114

FFackler, O. OP 93 P 418, P 419Fahnøe, U. P 231Falk, C. P 337Falk, J. P 169Falke, S. P 146Falkenau, A. P 56Fante, M. P 331Farahpour, F. P 163Fast, L. A. P 222Feeroz, M. M. P 43Feger, T. P 422Fehling, S. K. P 73Fehr, J. OP 93Fehrholz, M. P 403Feldmann, H. P 179, OP 52Felgenhauer, U. P 73Fellay, J. OP 128Fellenberg, J. OP 42Fernandez Garcia, Y. OP 37

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IIckler, J. P 77Iftner, T. P 422, P 260Imane, Z. P 415Imle, A. OP 93Ingale, J. P 445Ip, W. H. P 298Iqbal, A. A. OP 34

Isa, S. OP 121Ishida, Y. OP 36Isken, O. P 368Issmail, L. P 449Ithete, N. P 59Ivanova, L. OP 76Ivanusic, D. P 293

JJabaty, J. P 62Jacob, J. P 39Jacob, R. P 73Jacobsen, H. P 276Jagnjic, A. P 173Jahn, G. P 269 P 316, P 161, OP 137Jakobsen, M. R. P 81Jaksch, P. P 212, P 325Jakupi, X. OP 13Jang, H. P 425Jang, K. P 49Janga, H. P 393Jänsch, L. P 411Jansen, J. P 124Jansen, S. P 31, P 60, P 110Janson, D. OP 16Janssen, L. P 157Jany, S. P 447, P 448Jarmer, J. OP 103Jassoy, C. P 33, P 338Jiang, B. P 318 OP 78, P 143Jiang, Z. OP 91Jie, D. P 314Ji-Xhin, J. A. OP 64Jo, S. P 262Joas, S. P 49Joecks, S. P 266, P 209Johne, R. P 182, P 38Johnson, R. OP 36Johnston, C. P 231Jones, J. P 244Jones, K. OP 36Jonjic, S. P 173, OP 29Jønsson, K. L. P 81Jordan, A. P. P 172Joska, J. P 334Jöst, H. P 60Jost, L. OP 98Juan, A. P 351Juelg, B. P 244Juhasz-Böss, I. OP 84Jung, M. P 137Junglen, S. OP 122Jungnickl, D. P 229Juranic Lisnic, V. P 82Jurges, C. OP 19, P 219Juszczak, P. P 329

121


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Keppler, O. T. P 398 P 25, P 418, P 78Kessler, B. P 57

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Knodel, M. M. OP 112Knoester, M. OP 136Knöll, A. OP 80, P 339Knolle, P. OP 43, P 424Knop, V. P 318, P 143Knops, E. OP 134Koban, R. OP 94Kobbe, G. OP 16Koblischke, M. P 171KoÇ, B. T. P 69Koch, K. P 438Koch, M. OP 16Koch, S. OP 56, OP 89Koch-Nolte, F. P 438Kochs, G. P 99, P 410Kocks, C. OP 95Koehler, A. P 347Koellner, B. P 24Koepke, L. P 83Koestler, J. P 04Koethe, S. P 111Koether, K. OP 70Kohl, A. OP 30Köhler, N. P 304, P 17Kohrt, S. P 187Kolarich, D. P 397Kolenbrander, A. P 445Kolesnikova, L. OP 77Koltzenburg, M. OP 76Kondakci, M. OP 16Köndgen, S. P 40Kongola, G. P 335König, A. OP 35König, B. P 342König, F. P 87König, J. P 293König, P. P 111Kontchou, C. P 104Koopmans, M. OP 59 P 162Kopp, A. OP 122Köppen-Rung, P. OP 32Koppensteiner, H. OP 08Korencak, M. OP 48, P 329Korn, K. P 133, P 339, P 25Korth, J. P 09Kosinska, A. P 424Kottmann, D. P 58Kouadio, L. P 40Koutsilieri, E. P 334, P 335Kowalewski, D. OP 113Kraemer, B. P 04, OP 16Kraft, A. OP 61Krähling, V. P 52, P 103Kramer, D. P 283Krapp, C. P 367Krasemann, S. P 166Kraus, E. P 180Krause, E. P 82

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122


LL’Hernault, A. OP 113Lachmann, I. P 21Laenen, L. OP 32

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Manns, M. P 151 OP 135, OP 64, P 203Marcello, A. OP 15Marcotrigiano, J. OP 64Marcotte, H. P 438Markert, U. OP 122Markowski, J. OP 32Marschall, M. P 254 P 255, P 372, OP 22, P 187Martarise, R. OP 78Marteens, G. P 334Martellaro, C. OP 52Martin, C. P 349Martin, K. P 284Martin, S. OP 52Martins Netto, E. OP 35Marz, M. P 210, OP 114 P 214, P 215, OP 110 P 216, P 217, OP 40Mas Marques, A. P 26Maschkowitz, G. OP 120Masclee, G. OP 126Masemann, D. OP 70Matczuk, A. P 225, P 327Mathé, P. OP 121Matrosovich, M. P 124Matrosovich, T. P 124Matsvai, A. P 211Mätz-Rensing, K. P 67Mayer, B. P 49Mayer, J. P 299 P 267, OP 36Mayer, M. P 81Mayr, T. P 56McCowan, C. P 58McIlroy, D. P 130McInerney, G. P 366 P 396McKewen, G. OP 36Mckinstry, W. J. OP 107McLauchlan, J. OP 112Mecate-Zambrano, A. P 265Medialdea, R. OP 14Medits, I. OP 04 OP 103, P 36Meemark, T. P 191Meers, J. OP 36Meese, E. P 299Megger, D. A. OP 12 OP 24Mei, Y.-F. P 161Meijer, A. P 326Meiler, A. P 410Meissner, F. P 266Meister, T. L. P 122Meixenberger, K. P 89, P 10Melamed, S. P 42Melchior, F. P 273

123


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NNabi, G. OP 107Nägel, A. OP 112

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PPaal, C. P 206Pache, L. OP 128Pachota, M. P 199Paki, K. OP 53Pallasch, E. P 166Palmarini, M. OP 109Paludan, S. R. OP 29Pam, V. OP 121Pan, Q. P 355Panas, M. P 366, P 396Pandey, A. P 150Pankraz, A. P 282Panning, M. P 321, OP 121Papies, J. P 113

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Plachter, B. P 370, P 380Planès, R. P 294Plattet, P. P 136Plentz, A. P 331Pleschka, S. P 178, P 378 OP 34, P 274, P 191Plevka, P. P 292Plociennikowska, A. P 108Ploegh, H. P 361Ploen, D. P 181, P 44Plotzki, E. P 56Pluskota, B. P 31Poelman, R. OP 136Pogan, R. OP 74Pohlmann, Anj. OP 76Pohlmann, An. OP 54Pöhlmann, S. P 283 P 123, P 72, P 103 OP 102, P 208, P 63, P 64Polcik, L. P 100Pollak, K. P 325Pompaiah, M. P 234Ponnurangam, A. P 109Pons Tamarit, J. P 22Poodt, J. P 11Popowicz, G. OP 82Popow-Kraupp, T. OP 138Port, J. R. P 166Portmann, J. OP 86Postel, A. P 368 P 71, P 08, P 282, P 46Posthaus, H. P 290Potgieter, T. P 185Praditya, D. P 186Prank, U. P 250Preiser, W. P 59Preisinger, C. P 385Prescott, J. P 80Previdelli, R. L. P 302Prochnow, H. P 207Protzer, U. P 307, OP 43P 424, P 125 P 196, OP 132Puchhammer-Stöckl, E. P 212, P 126, P 325Pyrc, K. P 129, P 127, P 199

QQi, J. P 343, P 118Qian, Y. OP 31Qiang, Y. P 419Bingqian, Q. P 252, P 295Changbo, Q. P 355Quadenau, C. OP 36Qurishi, N. OP 134

RRabenau, H. F. P 25Rackow, A. OP 13, OP 14Radivojkov-Blagojevic, M. OP 68Raftery, M. J. P 421Rajaâ, B. P 415Rajalingam, K. OP 79Rajewsky, N. OP 95Rall, I. P 443Rameix-Welti, M.-A. P 207Rammensee, H.-G. P 422Ramnarayan, V. R. P 157 P 220Ramos-Nascimento, A. P 228Ran, W. OP 54Rapp, U. R. OP 70Rappe, J. P 290Rasche, A. OP 35Rascle, A. P 03, P 04, OP 16Rashwan, E. P 195Rassart, E. P 272, P 120Rauen, U. P 237Raupach, R. OP 133Rautenschlein, S. OP 34 P 58Ravits, J. P 267Real, C. P 90Rebel-Bauder, B. P 292Rebello PInho, J. R. OP 35Reckendorf, A. P 241Reddehase, M. J. P 289 P 405Redecke, L. P 146Reibetanz, U. P 247Reichart, B. P 56, P 57Reiche, J. P 328Reiche, S. P 33, P 34Reichel, A. OP 130 P 93, OP 10Reichl, U. P 208Reimann, I. P 111Reimer, R. OP 74, P 227Reindl, S. OP 37Reinhardt, A. P 21Reiß, K. OP 06Reith, E. OP 07, P 83Ren, H. P 97Renders, L. OP 16Renken, C. P 336

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XXi, J. P 422Xiao, Hai. P 343Xiao, Han. P 406Xiao, Q. P 78Xiao, Y. P 272, P 120Xiong, H.-R. P 359Xu, S. P 412, P 109Xu, X.-Q. P 98

YYan, H. P 131Yanagihara, R. OP 32Yang, Q. OP 25Ye, L. OP 46Ye, X. P 301Yigitliler, A. P 422Yilgwan, C. OP 121

You, S. P 209Young, P. OP 36Yu, P. P 416Yu, S. P 314Yuan, Q. P 314Yuksel, S. P 239

ZZaeck, L. P 76Zaghloul, E. P 195Zahn, T. P 427Zaidane, I. P 114Zakaryan, H. P 193Zange, S. P 324Zech, F. OP 07Zeglen, S. P 129Zehl, M. P 200Zehnder, B. OP 118, P 295Zeichhardt, H. P 25Zelinskyy, G. OP 62 P 268, P 158Zell, R. P 95Zeman, F. P 03Zeng, J. P 244Zeuzem, S. P 318, P 143Zhang, B. P 98Zhang, Ming. P 404Zhang, Minz. P 221Zhang, S. P 118Zhang, T. OP 31Zhang, W. P 309 P 132, P 202, P 311, P 138Zhang, Y.-Z. P 359, IL 05Zhang, Ze. OP 49, P 357Zhang, Zhenf. P 75Zhang, Zhenh. P 90

Zhao, J. P 355Zhao, Lil. P 125Zhao, Lin. OP 31Zheng, X. OP 106Zhong, C.-J. P 359Zhou, J. P 275, OP 111Zhou, N. P 275, OP 111Zhou, R.-H. P 98Zhou, X. OP 25Zhu, N. P 359Zhu, R. OP 31Zhu, S. P 407Zickler, M. P 101Ziebuhr, J. P 178, OP 40Ziegler, U. P 34Zillinger, T. P 412, P 109Zimmer, B. P 431, P 442Zimmer, G. OP 104 OP 02, OP 88Zimmer, R. OP 113Zimmermann, A. P 165Zimmermann, Ch. P 370 P 380Zimmermann, Co. OP 113 P 391, P 417Zimmermann, J. P 323Zimmermann, L. P 373Zinke, A. P 346Zischke, J. P 02, P 337Zörndlein, F. P 251Zust, R. OP 86Zverev, V. P 402

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