Genetics Society of America

1993 Records, Proceedings and Reports

Published as supplementary material in GENETICS, Volume 134

Prepared by The Secretary Shirleen Roeder

Department of Biology Yale University

New Haven, Connecticut

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BOARDS, COMMITTEES AND REPRESENTATIVES FOR 1993

BOARD OF DIRECTORS A. Dale Kaiser, President Bruce S. Baker, Vice President Shirleen Roeder, Secretary Carol S. Newlon, Treasurer John C. Lucchesi, Past President John W. Drake, Editor

GENETICS EDITORIAL BOARD John W. Drake, Editor Sally Lyman Allen Karen Artzt Douglas E. Berg David Botstein John E. Boynton Anthony H. D. Brown Michael Bulmer Benjamin Burr Marian Carlson Deborah Charlesworth Peter Cherbas Joanne Chory Arthur Chovnick Andrew G. Clark Thomas W. Cline Rowland H. Davis Robin E. Denell Norman R. Drinkwater Walter F. Eanes Warren J. Ewens Victoria G. Finnerty Margaret T. Fuller

ADMINISTRATIVE OFFICE Elaine Strass, Executive Director

Karen Artzt Welcome Bender Barry S. Ganetzky Christine Guthrie Barbara J. Meyer Elliot M. Meyerowitz

Roger E. Ganschow G. Brian Golding Maureen R. Hanson Robert K. Herman William G. Hill Alan G. Hinnebusch Nancy A. Jenkins Sue Jinks-Robertson Mark Johnston Elizabeth Jones Cathy C. Laurie Wen-Hsiung Li Michael Lynch Trudy F. C. Mackay Russ Maurer Patricia J. Pukkila Trudi Schupbach William F. Sheridan Michael J. Simmons Montgomery Slatkin Gerald R. Smith Bruce S. Weir Fred Winston

Barbara Abbott, Publications Assistant IASHG Membership Coordinator Sharon Adler, Comptroller Assistant Judy Ashton, Office Coordinator Candis Galkin, Meetings Assistant Gloria Garber, Membership Assistant Karen Gould, Comptroller Margot Kiley, GSA Membership Coordinator Krista Koziol, Publications Manager Anne Marie Langevin, GSA Meetings Manager Marsha Ryan, ASHG Meetings and Exhibit Manager Jane Salomon, ASHG Special Projects Manager

COMMITTEES Executive Bruce S. Baker

A. Dale Kaiser John C. Lucchesi Carol S. Newlon Shirleen Roeder

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Affiliations Contacts

Education

Genetic Stock

Nominating

Office Management

1994 Program

REPRESENTATIVES Council of the International

Genetics Federation

Assembly of Life Sciences, National Research Council

American Type Culture Collection

George B. Witman, Chlamydomonas Representative Peter A. Lefebvre, Chlamydomonas Representative Mariana F. Wolfner, Drosophila Representative Victoria G. Finnerty, Drosophila Representative Timothy Nelson, Maize Representative Edward H. Coe, Jr., Maize Representative John L. Woolford, Jr . , Yeast Representative George F. Sprague, Jr., Yeast Representative

Leland H . Hartwell, Chair Thomas R. Mertens Leslie K. Derr Lynn S. Ripley Diane M. B. Dodd Gerold Schubiger

John L. Haynie Gail M. Simmons

David L. Jameson Barton E. Slatko Charles Laird William Sofer Thomas R. Manney Vinton Thompson

Kathleen A. Matthew, Chair Robert K. Mortimer Barbara J. Bachmann Calvin 0. Qualset Nicholas W. Gillham Charles M. Rick Elizabeth H. Harris Thomas B. Shows Robert K. Herman Ronny C. Woodruff Susan E. Lewis

Rochelle Easton Esposito, Chair Terrence W. Lyttle Martin Chalfie Shirleen Roeder, ex ofJicio Elaine Strass, ex ofjcio

Carol S. Newlon, GSA Treasurer, Chair Bruce S. Baker, GSA Vice President Shirleen Roeder, GSA Secretary W. Allen Hogge, ASHG Treasurer Janet D. Rowley, ASHG President Ann C. M. Smith, ASHG Secretary

Jasper Rine, Chair Bruce S. Baker Jerry Feldman Elliot M . Meyerowitz

John W. Drake Elliot M. Meyerowitz, ex o f i c io John C. Lucchesi, ex osficio

Shirleen Roeder, ex officio

Calvin 0. Qualset

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PAST AND PRESENT OFFICERS OF THE SOCIETY

1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950

1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 I986 1987 1988 1989 1990 1991 1992 1993

President L. (1. Dunn R. A. Emerson Sewall Wright D. F. Jones P. W. Whiting E. M. East L. J. Stadler M. Demerec L. J. Cole Th. Dobzhansky E. W. Lindstrom M. M. Rhoades A. H. Sturtevant B. McClintock G. W. Beadle H. J. Muller I.. H. Snyder 7'. M. Sonneborn Curt Stern

M. R. Irwin J . W. Gowen R. E. Clausen. J. 1'. Patterson P. C . Mangelsdorf R. E. Cleland R. A. Brink C . P. Oliver Karl Sax J. F. Crow B. P. K a u f t n a n n R. D. Owen Jack Schulz S. Emerson M'. L. Russell E. W. Caspari E. B. Lewis H. L. R o m a n

N. H. Giles, Jr. R. P. Wagner R. I). Hotchkiss M. M. Green B. Wallace 0 . Smithies E. S. Kussell D. D. Perkins M. Shaw

M'. K. Baker E. Sears

B. H. Judd H. L. Carson M. L. Pardue R. W . Allard I . Herskowitl D. L. Lirtdsley E. W. Jones G. R. Fink D. L. Hart1 R. L. Metzenberg I>. H. Hartwell J. C. Lucchesi A. D. Kaiser

C. Yanofsky

Editors

D. E. Jones (1 926- 1935)

M . M. Rh~ades ( 1 940-1 946)

G. H. Schu l l ( l9 16- 1925)

L. c. Dunn (1 936- 1939)

Vice-f resident F. D. Richey Sewall Wright D. F. Jones P. W. Whiting I,. J. Stadler L. J . Cole M. Demerec B. McClintock Th. Dobzhansky E. W. Lintlstrorn M . M. Rhoades G. W. Beadle B. P. Kaufmann P. C. Mangelsdorf Karl Sax I*. H. Snyder 1'. M . Sonneborn Curt Steven M. R. Irwin

J. W. Gowen R. E. Clausen W . R. Singleron R. A . Brink R. E. Cleland J. I>. B L I S ~ <:. P. Oliver J. F. Crow J. W. Boyes H. B. Glass R. I). Owen W. L. Russell S. Enterson H. L. Roman E. W. Caspari E. B. Idelcis H. L.. Roman

N. H . Giles. Jr. R. P. Wagner R. D. Hotchkiss M . IM. Green B. Wall;rce 0 . Smithies E. S. R~~sse l l D. D. Perkins M . Shaw E . Sears W. K . Baker B. ti. Judd H. I.. Carson M. I.. Pardue R. W'. Allarti I . Herskowit7 I). L. Lindsley E. W. Jones G . K. Fink 1). 1.. Hart1 R. 1.. Metzenberg 1.. H. H;rrttcell

A . I). Kaiser J. C . 1.ucchesi

B. 5. Baker

(;. \';Inofsky

Secretary-Treasurer P. W. Whiting 1'. M'. Whiting P. W. Whiting M. Demerec M. Demerec M. Dernerec E. W. Lindstrom E. W. Lindstrom E. W. Lindstrom B. P. Kaufnlann B. P. Kaufmann 8. P. Kaufmann 1.. H. Snyder L. H. Snyder L. H. Snyder hl. R. Irwin M. R. Irwin M . K. Irwin W. R. Singleton

Secretary W. R. Singleton W. R. Singleton C. P. Oliver <;. P. Oliver C . P. Oliver H . B. Newcombe t1. B. Newcombe H. B. Newcombe W. L. Russell W. L. Russell W'. L. Russell E. B. Lewis E. B. Lewis E. B. Lewis K. 1'. Wagner R. P. Wagner R. P. Wagner B. Wallace 13. Wallace B. Wallace M . w . Shaw R4. w. Shaw M. W. Shaw B. H. Judd B. H. Judd €3. H. J ~ t d d <;. R. Fink G . K. Fink G . R. Fink D. T. Su;.uki D. ?'. Sumki D. -1. Suzuki 14. W. Lewis H. W. 1.ewis H. W. Lewis A. P. Mahowald A. P. Mahowald A. P. Mahowald 7'. C . Kaufman T. C. Kaufman T. C . Kauf~nan S. Roeder S. Roeder

Treasurer E. W. Caspari E. W. Caspari E. W. Caspari N. H. Giles, Jr. N. H. Giles, Jr. N. H. Giles, Jr. R. D. Owen R. D. Owen R. D. Owen D. Schwartz D. Schwartz D. Schwartz E. Novitski E. Novitski E. Novitski A. H . Sparrow A . H. Sparrow A. ti. Sparrow D. R. Stadler D. R. Stadler D. R. Stadler G. Lefevre G. Lefevre G. Letevre D. Lindsley D. Lindsley D. Lirtdsley U'. Welshons W. Welshons W. Welshons A. Chovnick A. Chovnick A. Chovnick R. E. Esposito R. E. Esposito R. E. Esposito A. C. Spradling A. C. Spradling A. C . Spradling C. S . Newlon C. S. Newlon C . S. Newlon C. S. Newlon

F. W. Casoari I 1 968- 1972) C. Stern (1947-1951) R. A. Brink 8c J , F. Crow (1952-1956) D. R. Stadler (i973-1976j C. P. Oliver 8c W. S. Stone (1957-1962) G. Lefevre (1977-1981) D. D. Perkins ( 1 965-1967) J. W. Drake (1982-1996)

BYLAWS OF THE GENETICS SOCIETY OF AMERICA

(Revised August 25, 1988)

The Genetics Society of America is organized to provide facilities for association and conference among students of genetics, to promote the commu- nication and publication of scientific knowledge, to promote education and research in genetics and to encourage interaction between workers in genetics and those in related sciences.

ARTICLE 1. Membership.-All persons interested in genetics shall be eligible for active membership. Any person who has been an active member of the Society for 20 years and who has retired is eligible for emer- itus membership. Categories of membership shall be established by the Board of Directors.

ARTICLE 2. Officers and Board of Directors.-The officers of the Society shall be a President, a Vice- President who is also President-Elect, a Secretary and a Treasurer. They, together with the immediate Past- President, the Editor of GENETICS and six other mem- bers elected by the Society shall constitute the Board of Directors. Each Board member shall have one vote. The Board shall meet at least once each year. Addi- tional meetings may be called by the President.

Executive Committee: The Executive Committee of the Board of Directors shall consist of the President, Vice-president, Secretary, Treasurer and one of the elected directors selected by the Board at its annual meeting. The Executive Committee shall act by ma- jority vote in matters that require attention between regular Board meetings.

Election and Terms of Office of officers and Board Members: The officers of the Society shall be elected by a simple majority of ballots cast by members of the Society. Each year the Nominating Committee shall submit the names of at least two nominees for each position to be filled, taking into consideration candi- dates suggested to the Secretary or the Nominating Committee. The ballot, mailed to a l l members i n good standing, shall list the nominees and also provide spaces for write-in votes. At the end of the first year of service, the Vice-president shall automatically be- come President and shall serve for one year in that capacity and for one year thereafter as a director. Every third year the ballot shall include nominees for Secretary. The Treasurer shall be elected every third year, but not in the same year as the Secretary.

Members of the Board of Directors who hold no other office shall be elected by the membership. Each year, the Nominating Committee shall submit the

names of at least four nominees, and the two receiving the largest number of votes shall be elected to serve for three years.

Terms of all officers and members of the Board shall begin on January 1 of the year following their election and shall end on December 31 of the year ending their term.

ARTICLE 3 . Meetings.-An annual meeting open to the entire membership of the Society shall be held at a time and place designated by the Board of Directors. During the annual business meeting of the member- ship, which shall be held during the annual meeting, the Board of Directors shall make its annual report IO

the membership, including the results of the election of officers and directors. Special meetings may be called by the Board of Directors. Twenty members shall constitute a quorum for any annual or special business meeting.

The program shall be arranged by the Secretary in accordance with the program rules adopted by the Board of Directors. The Board of Directors may arrange for joint programs with related scientific so- cieties, and for presentation of invited papers.

ARTICLE 4. Dues.-Annual dues for the various classes of members shall be fixed by the Board of Directors. Dues shall include a subscription to GE- NETICS. Graduate students who provide evidence of their status are entitled to active membership at ap- proximately half the regular dues for a period not exceeding five years. Husbands and wives both quali- fying for membership individually may elect a com- bined membership entitling them to a single subscrip- tion to GENETICS while entitling each to be listed as a member and to vote. Emeritus members may elect to continue to receive GENETICS by paying approxi- mately half the regular dues, or they may elect not to receive the Journal and be exempt from paying dues. Payment for all classes of membership shall be due January 1. New members shall be billed for dues from the previous January 1 and shall receive GENETICS for the entire year. Members whose dues are in arrears shall not receive publications or communications of the Society and shall be ineligible to vote. Members in arrears for one year shall be dropped from the rolls. A member who has been dropped for nonpay- ment of dues may be reinstated upon payment of dues for the year in which reinstatement is desired.

ARTICLE 5. Publications.-The Society shall pub-

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lish GENETICS as its official journal. Subscription to GENETICS shall be considered an integral part ofactive membership. T h e subscription rate to nonmembers shall be set by the Board of Directors, and shall not be less than the dues for active members of the Society.

GENETICS shall be a periodical record of investiga- tion into heredity and variation. Publication in the Journal shall be open to members and nonmembers alike. Acceptance shall be decided after editorial re- view solely on merit and suitability.

Editorial Board. An Editorial Board of GENETICS shall be appointed by the Board of Directors. Editorial Board members shall serve three-year terms which may be renewed by the Board of Directors. T h e Editor shall be appointed by the Board of Directors for a term of five years, but such appointment may be extended or terminated at any time by a two-thirds vote of the Board of Directors. T h e Editor shall be consulted about the Editor’s term of appointment, but shall not vote thereon. The Board of Directors and the Editorial Board shall advise the Editor in matters relating to Journal policy and shall, with the Editor, determine editorial policy for the Journal in all re- spects not specified by these Bylaws.

T h e Editor of GENETICS shall carry out policy de- cisions of the Board of Directors and shall be author- ized to act for the Editorial Board in arriving at editorial decisions and in conducting routine business. The Editor shall arrange meetings of the Editorial Board as necessary or upon written request of three members of the Editorial Board. The Editor shall preside over meetings of the Editorial Board and shall cast the deciding vote in case of a tie. The Editor shall, on request, communicate recommendations of the Board of Directors or of Society members to the Editorial Board and shall represent the Editorial Board in dealing with the Board of Directors. T h e Editor shall submit an annual report to the Society regarding the operation of GENETICS. The Editor shall, in cooperation with the Editorial Board and the Board of Directors, take measures necessary to assure an appropriate income from membership dues and subscriptions.

ARTICLE 6. Administrative Office.-An administra- tive office shall be maintained for conducting the business of the Society. It shall attend to such other matters as dictated by the Board of Directors. Super- vision of the administrative office shall be the respon- sibility of the administrative director, who shall imple- ment the policies decided by the Board of Directors. T h e administrative director shall provide staff support to assist the officers of the Society in carrying o u t their responsibilities. The President shall have respon- sibility and ultimate authority for the administrative office and resolution of any conflicts related to it.

ARTICLE 7.-Duties of Of$cers and Board of Direc- tors.-The President shall preside at the meetings of the Society and the Board of Directors. With the advice of the Board of Directors, the President shall appoint such committees and representatives as may be needed. The Vice-president shall preside in the absence of the President. In the event of a vacancy in the office of President, the Vice-president shall be- come President for the remainder of the unexpired term as well as for the subsequent term. In the event of any other vacancy among the officers or directors, the Board shall appoint an active member to serve for the remainder of the year, and the office shall be filled at the next annual election.

The Secretary, in cooperation with the administra- tive office, shall: (1) keep the records of the Society; (2) direct the arrangement of meeting plans in accord- ance with the rules formulated by the Board of Direc- tors and function ex officio on the Program Committee; (3) send to all members the date and place of the annual meeting, a call for papers to be presented at that meeting, and a call for suggestions for nomination for all offices to be filled by election. Not later than one month before the annual meeting, the Secretary shall send all members in good standing a ballot bear- ing the names of nominees for office; (4) T h e Secre- tary shall prepare minutes of the annual meeting and shall present an annual report to the members con- cerning actions of the Board of Directors, activities of the Society and its committees and representatives, and the membership of the Society; and ( 5 ) shall deposit those records of the Society no longer needed for current business in the historical collection of the Library of the American Philosophical Society.

The Treasurer shall: (1) have charge of all funds of the Society and be responsible for their investment; (2) be bonded in an appropriate amount fixed by the President; ( 3 ) send to all members bills for annual dues; and (4) prepare an annual statement to the members of the financial status of the Society, to be audited by a certified public accountant. (5) The Treasurer shall provide the administrative director and the editor of GENETICS with funds sufficient to operate the administrative office and to publish GENETICS.

ARTICLE 8. Committees: Nominating Committee.-A Nominating Committee shall be named each year by the Board of Directors and shall consist of three active Society members who are not members of the Board and who include representatives of different areas of genetics. In addition, the Secretary shall be ex ofJicio a non-voting member of the committee. NO person shall serve as a voting member on the Nominating Committee more than once during any four-year period.

Other Committees: The President shall create and

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appoint members to such other committees as are voting, provided that any proposed amendment, deemed necessary or advisable by the Board of signed by five members, has been submitted in writing Directors. to the Secretary at least three months before the

ARTICLE 9. Amendments.-Amendments to these annual meeting and has been communicated to the Bylaws may be adopted at the annual business meeting members of the Society at least two weeks before the by a two-thirds vote of the members present and annual meeting.

REPORT OF THE TREASURER

The following is the unaudited financial statement for the fiscal year 1992. The audited statement is available from the Administrative Office.

BALANCE SHEET December 3 1,1992

Assets Administrative Office-Checking Cash on Hand Editor’s Office-Checking/Petty Cash Drosophila Savings Account Prepaid Expense Accounts Receivable Due from ASHG Due from Drosophila Community Bulk Mail Deposit Accrued Interest

Total Current Assets

Merrill Lynch Cash Management Account Certificates of Deposit Corporate Bonds Equities Vanguard Mutuals

Total Investments

Furniture and Equipment Less: Accumulated Depreciation

Total Furniture and Equipment

Total Assets

Liabilities and Fund Balances Accounts Payable Accrued Annual Leave Accrued Payroll Deferred - Member Dues and Subscriptions Deferred - Discount Publications Sales Deferred - Nonmember Journal Subscriptions

Total Liabilities

General Fund Fund Balance at January 1, 1992 Excess (Deficit) of Revenue Over Expenses General Fund Balance at December 3 1st

Fund Balance at December 3 1 st Reserve Fund

Total Fund Balances

$ 90,865.48 50.00

7,443.68 6,282.03

107,144.98 53,679.55 12,560.34 7,032.68 1,000.00

14,595.00 $ 300,653.74

$ 19,883.23 720,000.00

19,479.02 53,274.47 10,000.00

022,636.72

$ 85,848.85 (59,616.47)

26,232.38

$ 97,885.54 9,973.32

1 1,403.33 146,195.62 66,099.00 60,840.28

$ 392,397.09

$519,372.36 (1 2,246.6 1)

$ 507,125.75

250,000.00 $ 757,125.75

Total Liabilities and Fund Balances $ 1,149,522.84

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STATEMENT OF REVENUE AND EXPENSES For the Year Ending December 31, 1992

Revenue Membership Journal Sales Discount Publications 1992 Drosophila Conference Chlamydomonas Conference Interest Income-Administrative Office Interest Income-Investments Dividend Income-Investments Gain on Sale of Securities Miscellaneous Income

Total Revenue

Expenses Membership Journal Publishing Discount Publications 1992 Drosophila Conference Chlamydomonas Conference 1992 GSA Annual Meeting Awards Other Expenses Administrative Office

Total Expenses

Excess (Deficit) of Revenue over Expenses

$ 195,047.7 1 615,337.07 146,819.04 117,384.03 95,595.25

4,O 16.92 79,857.34

6,051.65 10,48 1 .70 5,576.37

$ 1,276,167.08

$ 95,584.63 575,107.73 134,03 1.98 105,181.63 99,923.95 12,060.38

1,433.00 72,628.16

192,462.23

1,288,413.69

$ (12,246.61)

CAROL S. NEWLON, Treasurer

PROCEEDINGS OF THE 61ST ANNUAL BUSINESS MEETING

June 18, 1992 Earle Brown Center, University of Minnesota, St. Paul

The meeting was called to order at 7:OO PM by President J. C. Lucchesi.

Editor’s Report (J. W. Drake): J. Drake projected a 17% increase over 1991 in the number of pages printed in the Journal. The number of institutional (nonmem- ber) subscribers is down from 199 1 , but the number of members has increased. Drake feels these trends indi- cate that the profit to the Society for the Journal this year will dip somewhat. Drake feels the Journal is strong enough to raise the price to $240/$250 for 1993, an increase which had been approved in October 199 1. He stated that the editorial board should be expanded.

Secretary’s Report (S. Roeder): The minutes of the October 6, 1991, Business Meeting were approved as published in the June 1992 issue of GENETICS (Vol. 13 1). Approximately one-third of the membership voted in the 1992 election. Effective January 1, 1993, A. D. Kaiser will become president, B. S. Baker will become Vice-president, and C. S. Newlon will begin her second term as Treasurer. B. Meyer and E. Meye- rowitz will serve three-year terms as directors.

At May 31, 1992, GSA had 3,401 paid members (2,568 Regular, 400 Student, 158 Husband/Wife, 21 4 Emeritus and 61 Affiliates) and 382 who did not pay 1992 dues for a total of 3,783. While there has been a net gain of 1,264 members over the last 7 years, it should be noted that the gain over 2-year periods, which takes into account irregularities caused by the Directory publication cycle, has decreased and the num- ber of unpaid (inactive) meinbers who are dropped in March of each year continues to rise. Drosophila re- searchers still comprise the largest organized subgroup component of the membership.

Treasurer’s Report (C. S. Newlon) 1991 Audit: At audit, adjustments were made to change from the cash basis of accounting to the accrual basis. This resulted in an increase in assets of $134,440 and a reduction of the General Fund balance of $277,258. The General Fund revenue of $1,237,476 exceeded expenditures of $1,173,269 by $64,207, the Reserve Fund balance remained at $250,000 and the Larry Sandler Memorial Fund balance ended at $24,515. Therefore, at 12/3 1 /9 1 the fund balances, excluding the Memorial Fund, totaled $766,706. The reason for the change to accrual accounting is as stated in the audit, “This change was made in order to provide a better matching of revenues and expenditures, comply

with generally accepted accounting principles and re- flect financial position and results of operations more consistently with other similar not-for-profit organiza- tions.”

The 1992 Budget: The budgeted net income for the Drosophila and Chlamydomonas conferences together is now at $14,979, but the projected actual for Dro- sophila is $1 1,434 and for Chlamydomonas is -$5,18 1. Together the projected actual is more in the neighbor- hood of a net income of $6,250.

At its February meeting the Board voted to provide $25,000 to the Joint Steering Committee for Public Policy, a congressional education effort which will be undertaken in conjunction with the American Society for Cell Biology, the Biophysical Society and the Amer- ican Society of Biochemistry and Molecular Biology. This amount has been reduced to $19,824 because the Society’s participation did not begin until the end of the first quarter and the first payment was not made until the second quarter.

The resulting net income for the 1992 budget stands at $ 2 , 2 7 3 .

The Society’s Financial Statement f o r the Period Ended 3/3l/YZ: Total assets are $1,412,414.21. There are increases i n liabilities over last year because under the accrual basis of accounting all receipts for member dues and subscriptions, publications and income from Waverly for nonmember subscriptions must be deferred and recognized quarterly according to the budgeted amounts.

Meetings (A. M. tangevin, GSA Meetings Manager): Irwin Rubenstein, Local Arrangements Chairman for the 1992 GSA Annual Meeting at the University of Minnesota in St. Paul, reported that the attendance would be about 200, including 50 local attendees and 30 from the University of Wisconsin. A. Dale Kaiser, 1991 Thomas Hunt Morgan Medal recipient, and Bruce Baker, 1991 GSA Medalist, were scheduled to present talks at the meeting. The Board decided to subsume the 1993 meeting in the XVIIth International Congress of Genetics which will be held August 15-2 1 , 1993, in Birmingham, UK. The next GSA meeting will be held at Asilomar Conference Center in the fall of 1994 under the leadership of Jerry Feldman.

The 1992 Annual Drosophila Research Conference, sponsored by the GSA, was held March 10-1 6 at the Wyndham Franklin Plaza in Philadelphia. There were

1,112 registrants and 660 contributed papers. The meeting wasjudged to be a critical and financial success. The 1993 meeting will be held March 3 l-April 4, 1993, at the Town and Country Hotel in San Diego, California.

GSA also sponsored the 5th International Confer- ence on the Cell and Molecular Biology of Chlamydo- monas. The meeting was held May 26-31, 1992, at the Asilomar Conference Center in Pacific Grove, Califor- nia. The meeting was a success with 182 registrants and 14 1 abstracts submitted. Chlamydomonas will meet again in 1994 under GSA sponsorship and manage-

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ment. In 1994 the GSA will for the first time sponsor the Maize Annual Meeting.

GSA Awards: Lucchesi announced that Maynard Olson was awarded the 1992 GSA Medal for outstand- ing contributions to genetics within the past 15 years, and Edward H. Coe was awarded the 1992 Thomas Hunt Morgan Medal for a lifetime contribution to genetics. The medalists will present papers at the next GSA annual meeting.

The meeting was adjourned at 7:20 PM. Respectfully submitted,

ELAINE STRASS, Executive Director

REPORT OF THE COMMITTEE ON HONORS AND AWARDS

The Society makes two awards annually to honor members who have made outstanding contributions to the science of genetics. The Thomas Hunt Morgan Medal recognizes a lifetime contribution to genetics. The Genetics Society of America Medal recognizes

1993 Thomas Hunt Morgan Award: Ray D. Owen

The award of the Thomas Hunt Morgan Medal to Ray D. Owen is a recognition of his lifelong contribu- tions to genetics, not only as a discoverer of key prin- ciples in immunogenetics, but also as a teacher, as an author of a highly successful textbook on genetics, and through service to organizations such as The Genetics Society of America.

One of Ray Owen’s greatest contributions to the fields of vertebrate genetics and immunogenetics is the discovery of immunological tolerance, through a re- markable genetic analysis of twin cattle in which a circulatory anastomosis allowed reciprocal transplanta- tion of hematopoietic stem cells. He recognized from blood typing that the cattle had no immune response to the foreign antigens introduced from their twins. This discovery has had numerous scientific and practi- cal applications, among them the idea that immune suppression could allow tissue transplantation. In fact, Ray Owen first postulated that immunosuppressive treatments such as x-irradiation might allow incompat- ible transplants, and participated in the experiments in which bone marrow transplants to irradiated recipients were first successfully demonstrated. His later work included studies on human antibodies, blood group antigens, evolution of immune systems (including stud- ies of the genetics of scale transplantation in goldfish and of blood groups in buffalo and Rhesus monkeys), and genetic analysis of the major histocompatibility complex of the mouse. His laboratory identified the Ss locus, which first defined the S region of the mouse H- 2 complex.

As an educator, Kay Owen was co-author of the most widely used genetics textbook of its time: General Ge-

particular outstanding contributions to genetics within the past fifteen years. We are pleased to announce that the 1993 Thomas Hunt Morgan Medal wi l l be awarded to Ray D. Owen, and the 1993 GSA Medal will be awarded to Jonathan R. Beckwith.

netics by Srb and Owen (second edition by Srb, Owen and Edgar). This was probably the primary university genetics text from the publication of the first edition in 1952 until well after the 1965 publication of the second edition.

Ray Owen has held many important administrative positions in his career, among them: president of The Genetics Society of America in 1962, member of the Genetics Study Section of the National Institutes of Health from 1958 to 1961 and its chairman from 1961 to 1963, chairman of the Caltech Biology Division from 1961 to 1968, member of the Immunobiology Study Section of the National Institutes of Health from 1966 to 1967 and its chairman from 1967 to 1970, chair of the Genetics Section of the National Academy of Sci- ences from 1969’ to 1972, scientist-member of the three-person President’s Cancer Panel from 1972 to 1975, and dean of students and vice-president for stu- dent affairs at Caltech from 1975 to 1980. His long- term and renowned dedication to the nurturing of students in the sciences is evidenced by his having chaired the committee that both designed Caltech’s present freshman curriculum, and recommended the admission of women as Caltech undergraduates, which occurred in 1970 from Ray Owen’s work.

He was born on October 30, 191 5, on a dairy farm in Genesee, Wisconsin, and attended Carroll College in Waukesha, Wisconsin, from which he graduated with a B.S. degree in 1937. Kay Owen earned a Ph.D. in genetics from the University of Wisconsin in 194 1 , as a graduate student of L. J. Cole. His postdoctoral research from 1941 to 1943 was in association with the laboratory of M. R. Irwin, also at the University of

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Wisconsin. He then served as assistant professor at the University of Wisconsin, and moved in 1947 to the California Institute of Technology as an associate pro- fessor. He currently serves there as professor of biol- ogy, emeritus.

Ray Owen has been awarded an array of medals and honorary degrees befitting a scientist of his distinction, including the Mendel Medal of the Czechoslovak Acad- emy of Sciences in 1966 on the occasion of the Mendel

centennial. Among his Sc.D. degrees are those from his alma mater, Carroll College and from the University of Wisconsin. He is a member of the Genetics Society of America, the National Academy of Sciences, the American Academy of Arts and Sciences, the American Philosophical Society and many other professional and honorary organizations.

ELLIOT M. MEYEROWITZ

1993 Genetics Society of America Medal: Jonathan R. Beckwith

Jonathan Beckwith has been awarded the 1993 Ge- netics Society of America Medal in recognition of his contributions to the biology of E . coli and to the practice of molecular genetics. He is also honored for his lead- ership in the discussion of genetics and social policy.

Jon did both undergraduate and graduate studies at Harvard. He received his Ph.D. in 1961 for work with Lowell Hager on the biosynthesis of chlorinated com- pounds in fungi. He was most inspired in those days by the emerging fields of molecular genetics, especially by Jim Watson’s descriptions of the lac operon model of Jacob and Monod. Jon arranged a series of short post- docs to learn operon genetics, first with Art Pardee, then with Bill Hayes, Sydney Brenner, and finally Fran- cois Jacob. His efforts focused on mapping components of the lac operon with deletion mutations. He also discovered, with Brenner, ochre mutations and sup- pressors, and helped to define the nature of polarity of nonsense mutations.

Returning to Harvard in 1965, Jon joined the faculty of bacteriology and immunology at the Medical School, and has remained there. He continued a fine-scale dissection of the lac operon, and discovered, among other things, the CAP site used in catabolite repression. In 1969, he and his collaborators reported an elegant purification of the lac2 gene with its promoter and operator. The work predated the use of restriction enzymes; heteroduplex molecules were formed be- tween transducing phanges containing overlapping re- gions of the lac operon. This was the first isolation of a defined DNA segment from a bacterial genome.

Jon is perhaps best known for pioneering the use of gene fusions, and that approach has been a recurring theme in many of his investigations. The first fusions were between the lac and trp operons; they were used to map and analyze the promoter and operator regions of both operons, and the transcription termination sequences. The Beckwith lab was the first to use mobile elements to generate fusions randomly throughout the bacterial chromosome. These were used initially to put P-galactosidase under the control of the araC and malB promoters. These other operons could then be studied with the tools developed for lac. That approach is still widely imitated. Nearly 20 years, later, “traps” for

promoters, enhancers, and exons are being sprinkled through every genome with sufficient genetics, and P- galactosidase is still the flag of convenience.

Since the early 1970’s, Jon has focused the fusion technique on the mechanism of protein secretion. Fu- sions to alkaline phosphatase or maltose transport pro- teins led to the identification of the signal sequence for translocation across a membrane. Subsequent biochem- ical work defined the processing of signal sequences, and genetic studies identified a series of “sec” mutations which were blocked in secretion. An unusually produc- tive dialog developed among the labs working on the genetics, physiology, and biochemistry of secretion in bacteria, yeast, and mammals. This dialog led to a rapid growth and maturation of the field, because the clash of ideas motivated the decisive experiments. Beckwith brought a critical, articulate, and forthright voice to those discussions,

Gene fusions were also used in Jon’s lab to study integral membrane proteins, to define the orientation of trans-membrane domains, and the process of inser- tion of these proteins into the membrane. Fusions to alkaline phosphatase have also been used to study genes used for septum formation and cell division. Screens involving membrane fusion proteins have turned up novel players in protein processing. Proteases were found in the periplasmic space which degrade abnormal proteins, and recently, a periplasmic protein used for disulfide bond formation was discovered. These devel- opments have sparked Jon’s interest in the broader problem of protein folding.

Jon participated in the excitement of the early operon days, but he stayed with bacterial genetics when many of his colleagues switched to “higher” organisms. The loyalty has been rewarded; Jon has continued to dis- cover molecular mechanisms that bacteria share with most forms of life. He has always been an apostle for the culture of genetics. Jon has directed a genetics training grant through three renewals. He has inspired students for many years with his graduate course on prokaryotic genetics; they are impressed not only by Jon’s perspective, but also by the rigor of his analysis.

In addition to his scientific contributions, Jon has long worked to educate the public about the limitations

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of science, and to educate the scientific community about the social consequences of our results. He has focused particularly on the misapplication of genetics in the promotion of eugenics or behavioral determin- ism. He was a longstanding member of the group, Science for the People, and served as its president. He was also recently appointed to the Working Group on Ethical, Legal, and Social Implications of the Human Genome Initiative. This committee has tried to antici- pate the legal and social problems that might arise from

comprehensive genetic screening. For his discoveries in basic biology, for his commit-

ment to teaching the art of genetics, and for his concern for the impact of science on the general well being, Jon Beckwith has earned the gratitude and esteem of the genetics community. The 1993 GSA Medal is a token of that respect.

WELCOME BENDER A. DALE KAISER

Recipients of GSA Honors

Thomas Hunt Morgan Medal 1981 Barbara McClintock, Marcus M. Rhoades 1982 Sewall Wright 1983 Edward B. Lewis 1984 George W. Beadle, R. Alexander Brink 1985 Herschel L. Roman 1986 Seymour Benzer 1987 James F. Crow 1988 Norman H. Giles 1989 Dan L. Lindsley 1990 Charles Yanofsky 1991 Armin Dale Kaiser 1992 Edward H. Coe, Jr. 1993 Ray D. Owen

Genetics Society of America Medal 1981 Beatrice Mintz 1982 Gerald R. Fink 1983 Charles Yanofsky 1984 David S. Hogness 1985 Philip Leder 1986 Gerald M. Rubin 1987 Sydney Brenner 1988 David Botstein, Ira Herskowitz 1989 Allan C. Spradling 1990 Nancy Kleckner 199 1 Bruce S. Baker 1992 Maynard V. Olson 1993 Jonathan R. Beckwith

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REPORT ON THE GENETICS SOCIETY OF CANADA AWARDS

1992 Award of Excellence: Charles R. Scriver

Charles R. Scriver received the 1992 Award of Ex- cellence on the basis of his outstanding contributions to biochemical genetics, the practical application of genetics to human welfare, and the promotion of public awareness through lectures and political action.

Charles Scriver currently holds academic appoint- ments at McGill University in pediatrics and human genetics (biology). He is an associate of the Medical Research Council and director of deBelle Laboratory for Biochemical Genetics at the McGill University-Mon- treal Children's Hospital. He received his B.A. from the McGill University Faculty of Arts in 195 1, and graduated with an M.D. degree from the McGill Fac- ulty of Medicine in 1955. He is a fellow of the Royal College of Physicians and Surgeons, the American Academy of Pediatrics, and the Canadian College of Medical Geneticists. In addition to other scientific and honorary societies, he is a member of the Royal Society of Canada and the Royal Society (London).

He has received numerous honors and awards, in- cluding the William Allan Award (The American So- ciety of Human Genetics), Gairdner International Award (Gairdner Foundation, Canada) the McLaughlin Medal (Royal Society of Canada) and the Order of Canada, and is also a fellow of the American Association for the Advancement of Science.

Charles Scriver has made noteworthy contributions to the understanding of the transport of molecules across membranes by the study of the effects of mutant

1992 Young Scientist Award: Hugh W. Brock

Dr. Hugh W. Brock is an associate professor in the Department of Zoology at the University of British Columbia (UBC). He was awarded the 1992 Young Scientist Award for the development of a strong re- search program examining the function of the Polyho- meotic gene in Drosophila. He obtained a B.Sc. from UBC in 1977 and a D.Phi1. at Oxford in 1981. He did postdoctoral work at the University of Paris and the University of Washington. Hugh Brock has received numerous fellowships from noted organizations and has attracted significant research funding for his program at UBC.

Research in the area of segmentation and the control of determination, featuring the Polycomb group of genes that are important in the regulation of the expression

genes in mouse and in man. He has contributed to the development of methods for treating children with inborn errors of metabolism-practical methods that have prevented mental retardation and growth retar- dation in children with a variety of metabolic disorders. T o his credit as a scientist and a concerned citizen, he has extended his activities from the laboratory and patient to the general population. He was instrumental in developing the Quebec Network of Genetic Medi- cine that now screens virtually all babies born in Quebec for inborn diseases; he helped to develop a food bank with special diets for children otherwise unable to se- cure special diets; he campaigned to have vitamin D put in milk to help eliminate nutritional rickets; he contributed to the development and delivery of a report entitled,"Genetics and Canadian Health Care" through his six years on the Science Council of Canada; and he has worked to develop a population research group to investigate the origin and distribution of genes in the French Canadian population.

Equally impressive are Dr. Scriver's contributions to teaching, from his lectures at McGill and his graduate students to his presentations at meetings and symposia. In the eyes of his colleagues, he is one of those rare persons who is not only skillful in basic research, but also has the perception, motivation, persuasiveness and organizational ability to see that the knowledge derived from basic research is put to use in the service of man.

of the Bithorax Complex, is very topical and quite competitive. Dr. Brock's group has contributed several substantial pieces of information in this interesting re- search area. He cloned and characterized the Polyho- meotic gene in a collaborative effort between his group and another in France. His group has gone on to do extensive development analyses of the function of the protein product of this gene and interacting proteins by means of antibodies. He is expanding his research to include analysis of Additional sex combs gene and its protein product.

Hugh Brock is viewed by his colleagues as an ener- getic investigator with unusually eclectic interests, as reflected in the range of subjects and collaborations presented in his many publications.

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REPORT OF THE EDITOR

During 1992, the number of pages for articles was printed articles reflect submissions over a different and 3,184 and for the Records, Proceedings and Reports was more diffuse interval. Paid circulation increased by 16 for a total of 3,200. Pages for articles increased by 0.2% to 5,083. 12% over 199 1. The number of submitted manuscripts increased by 11.5% to 506 while the number of printed articles increased by 8.8% to 283; note, however, that JOHN W. DRAKE, Editor

REPORT OF THE SECRETARY

The Board of Directors met twice during 1992: in Atlanta, Georgia, February 29 and at the GSA gener- alist meeting at the University of Minnesota at St. Paul, June 18.

At December 31, 1992, GSA had 3,531 paid mem- bers (2,698 Regular, 456 Student, 154 Husband/Wife, 223 Emeritus) and 81 affiliates. 306 (8%) had not paid 1992 dues. At May 1993,245 of the 306 were dropped for nonpayment of 1991 dues. For 1992 there was a net gain of 135 which is slightly better than in recent years.

In the 1992 election Bruce S. Baker was elected Vice President. Barbara Meyer and Elliot Meyerowitz will serve three-year terms as directors replacing Nina V. Fedoroff and H. Robert Horvitz. Carol S. Newlon was re-elected treasurer and will serve through 1995.

The Board decided after discussing the June 1992 generalist meeting in Minnesota to continue holding annual meetings, but voted to subsume the 1993 meet- ing in the XVIIth International Congress of Genetics in Birmingham, England, August 15-2 1. The 1993 GSA Business Meeting will be held at that time. The 1992 meeting was organized by Irwin Rubenstein, Ron- ald Phillips and Burle Gengenbach. Perry Hackett, Robert Herman, Michael Simmons and John Doebley served on the Local Arrangements Committee. This campus meeting was attended by close to 200 persons. There were approximately 90 abstracts. The 1994 meeting will take place in the fall at the Asilomar Conference Center. Jasper Rine will chair the program

committee i n association with Jerry Feldman and oth- ers.

The 1993 Drosophila meeting was held March 3 1- April 4 at the Town and Country Hotel in San Diego, California. As usual the fly meeting was a success with over 1,200 registrants. Gerry Rubin chaired the Pro- gram Committee. The next meeting w i l l be held April 20-24, 1994, at the Sheraton Hotel in Chicago. Vic- toria Finnerty will chair the Program Committee.

The Yeast Genetics and Molecular Biology meeting was held June 8-12, 1993, at the University of Wiscon- sin, Madison. In 1994, this meeting will take place at the University of Washington, Seattle, changing the meeting pattern from odd- to even-numbered years. John Woolford and George Sprague will co-chair the 1993 meeting.

The biennial Chlamydomonas meeting, organized by George B. Witman of the Worcester Foundation for Experimental Biology, was sponsored for the first time by GSA and held May 26-3 1 , 1992, at Asilomar. There were 184 attendees. The second GSA-sponsored Chlamydomonas meeting will be held in 1994.

GSA representatives to the next International Con- gress of Genetics to be held August 1 5 " 1 , 1993, in Birmingham, England, are John C. Lucchesi, John W. Drake and Elliot M. Meyerowitz.

The GSA Board is planning to sponsor more orga- nismic meetings in future years including the 1994 maize meeting.

SHIRLEEN ROEDER, Secretary

REPORT OF THE GENETIC STOCK COMMITTEE

Many stock center curators are struggling with how to best provide access to their datasets. Many options are available, from flat files on diskette to stand-alone applications such as acedb, to interactive network serv- ers such as Gopher+-each with it’s own advantages and disadvantages, and new developments arise at a steady pace. The range of computing knowledge and access to computing expertise among stock center ad- ministrators is very broad. An ongoing forum for dis- cussing options, exchanging information, and asking for help could be extremely useful, and an e-mail discussion group is ideal for this kind of exchange. Our

REPORT ON THE AMERICAN

The Genetics Society of America is one of twenty- two professional scientific organizations represented on the Board of Directors of ATCC. Traditionally, a member of the GSA Genetic Stock Committee is nominated to serve on the ATCC Board. N. W. Gill- ham served as the GSA member on the Board for six years. He now serves as an at-large member, as does Ray Curtiss, who is also a former GSA representative to ATCC. Dr. Gillham made a comprehensive report last year (GENETICS 13 1 : sl5-s16) which outlined the goals and structure of ATCC. I began service on the Board in 1992 as an activity of the GSA Genetic Stock Committee. This report will review a portion of the ATCC activities and highlight some of the issues fac- ing it.

The ATCC Board met on March 25-26, 1993, at its facilities in Rockville, Maryland, and Airlie House, Virginia. It was an occasion to honor the retirement of Robert Stevenson, who served as director of ATCC for more than ten years. A new director has been selected: Raymond Cypess, D.V.M., Ph.D., who left a position as dean of the College of Graduate Health Sciences and vice provost for research, University of Tennessee, Memphis.

ATCC is providing a large service to the scientific community. Its holdings include six collections orga- nized as departments with the following numbers of accessions: Protistology (1 170), Virus (2722), Cell Cul- ture (2738), Molecular Biology (9364), and Mycology (24,766) as of March 1993. Each of the collections is managed by a curator and staff who maintain, regen- erate and prepare cultures for distribution. In addi- tion, each collection has a research function which it carries out to the extent that funds are available. In the past year about 153,000 cultures were distributed and 4207 new cultivars were accessioned. Its annual budget is about $15,000,000 with income generated

committee is sponsoring an unmoderated LISTSERV discussion group for anyone interested in these issues.

Calvin Qualset has organized a small workshop that will be sponsored by the National Science Foundation’s Division of Instrumentation Resources (Dr. Machi Dil- worth, Program Officer) to examine problems related to the long-term welfare of genetic stocks. The goal of the workshop is to help develop a means for ensuring the security of genetic stocks in species that have been extensively and intensively used in genetic research.

KATHLEEN A. MATTHEWS, Chair

TYPE CULTURE COLLECTION from sales of cultures, printed materials, patent dep- ository fees, grants and gifts.

ATCC serves as one of two approved patent depo- sitories in the U.S. for biological materials and now includes more than 11,000 cultures, of which more than 4500 are available for distribution. It holds 86% of the U.S. patent deposits. I t was the first interna- tionally approved depository by the World Intellectual Property Organization under the Budapest Treaty. The Patent Depository accepts, for a fee, microbes, cell lines, or other biological materials. It conducts a viability test and stores the materials for 30 years according to patent policy. I t held its 10th annual Biotechnology Patent Conference in 1992, which has beep very popular with patent attorneys and admin- istrators.

ATCC has recently made large acquisitions of hu- man cDNA clones sequenced in Venter’s NIH pro- gram. This includes 6800 clones; also, 1000 clones were received from Sikela’s program in Colorado. Already these are distributed at a rate of about 45 samples per month.

ATCC is interested in having major participation in biodiversity assessment and ex situ conservation and is ready to participate in multidisciplinary biological assessment programs. It has taxonomic expertise in many microbial groups and is planning to recruit two associate curators to overlap with current scientists who anticipate retirement in a few years.

Publication of catalogs and distribution of them by diskettes continues to be an important activity. In 1992, four were published: Human and Mouse DNA Probes and Libraries, Cell Lines and Hybridomas, Plant Viruses and Antisera, and Bacteria and Phanges. Cell Culture Quality Control Manual was also published.

The staff and Board members noted concern in several areas: (1) The queue of collections nominated for inclusion in ATCC is growing, but the physical

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and personnel capacity is limited to the extent that some collections cannot be accepted. (2) A balance between archival and active collections must be main- tained so that the cultures that are in demand by scientists, and therefore income-generating, can be managed efficiently along with collections for which there is little demand. (3) Integrity of collections must be maintained and ATCC is adopting new methods to diagnose contaminants and mislabelled accessions. For example, PCR technologies were used to show that a small proportion of animal cell lines were re- ceived with a virus contaminant. (4) Questions were raised about whether scientists are being trained with

traditional microbial taxonomic skills and about the future role for DNA-based taxonomy.

The most pressing need for ATCC, however, is to come to a decision about its insufficient laboratory, storage, and manufacturing space. A capital funding drive is underway and several potential relocation sites are being studied. ATCC was invited, but declined, to move to Ames, Iowa. A decision is to be reached in December 1993. This is an important decision for the whole scientific community and the 220 employees of ATCC. The Genetics Society of America is invited to participate in the capital funding drive.

CALVIN 0. QUALSET