Genetic Testing: How does the health system introduce and sustain genetics testing?

•  SUMMARY•  Genetictestingisevolvingquicklyandchoosingtherighttestfortherighttherapiesiscomplexasaresult.

•  Itiscriticalthatstakeholderscontinuetomeetandfindinnovativepathwaysforstoppingwhatisnolongeraddingvalueinthehealthsystemandfreeingupfundingfornewprecisionmedicinepathways,testingandtherapies(recognizingthismedicineiscompetingwithotherhealthsystemneeds).

•  Complexityofgenetictestingandtherapieswillcontinuetoputpressureonhealthsystembudgetsandtrade-offswillbenecessary;changesinstandardsofpracticewillneedtobemodifiedtoensurethetherapyisrespondingtochangesintestcapabilities;

•  CollaborationwithinBC,Canadaandgloballyisneededtodemonstrateclinicalefficacyofprecisionmedicine,achieveimprovedpatientoutcomesandensuresustainablefunding

•  AnumberofagenciesinBCandAlbertaareactivelyengagedinprecisionmedicine;attractingandretainingtalentsuchasgeneticcounsellorsandbioinformaticsisachallenge

•  ACTIONSTEPS•  Continuetoutilizecollaborationopportunitieswithhealthsystemstakeholderswithafocusonimprovingpatientoutcomes

•  PHSAprecisionmedicinestrategydevelopmentandplanningunderway;moretocome

CarolynBell

The Modern Patient •  Ourpatientswanttothanktheamazingscientistsandindustrypartnerswhoareworkingsohardtomakethistypeofcareareality.Withoutbelabouringthepoint,ourpatientsareimportant.Theyhaveavoiceandtheysupportandthankyouallforyourhardworkinmovingscienceforward.

SUMMARY•  Personalizedmedicinehasthepotentialtogreatlyaffectthepatientjourneyinapositiveway•  Patientswithcomplexacuteandchronicdiseasesundergotraumasaroundtheircareeveryday.Invasiveprocedures,dangeroustreatmentsandencounterswiththehealthsystemallhavethepotentialtocauseemotionalandphysicalharm.

ACTIONSTATEMENT•  Includepatientstoriesinfutureresearchandmarketing.Peoplereallyneedtohearthehumansideoftheworkthatyoudo.

•  Ourpatientshavealottoofferintermsofinvolvementinresearchideas,design,marketing.Involvepatientpartnersineveryaspectofcare.ThePatientVoicesNetworkisaBCbasedgroupofpeoplewhohaveencounteredthehealthsystemandwouldliketogivebacktomakehealthcaremoreinlinewithwhatourpatientswantandneed.

AnnemarieKaan

Personalized Medicine & Oncology - Key Points SUMMARY•  Highlystratifiedcancercareistoday’sbestmedicine–needforstratificationwillincrease•  Continuedchallengesofhowtoproveatargetthroughgenomicstreatmentapproachworksinaverysmallcohort(evenasinglepatient)andhowtogetregulatoryandfundingapprovalmaybegreaterthanhowtointerrogatethecancers

ACTIONS•  Patientadvocatesmaybekeytoaligningregulatoryprocessestotodaystreatmentopportunities

•  Thepediatriconcologyworldcouldbeusedasthepioneerforsharingdataacrossboardersandmorepersonalizedapproaches

•  Datasharingandaggregation,bothforindividualpatientsandacrosspopulations,isessentialifwearetofullytakeadvantageoftoday’sopportunities

DavidHuntsman

Data Analytics: An Exciting Frontier! SUMMARY•  Thedigitizationofsocietyismovingaheadwithorwithoutinputfromvarioussectors.Thehealthsectorislaggingothersectors.Healthhasthepotentialtobealeaderorlag–inwhichcaseothersectors/jurisdictionswillsettheprinciplesthatgovernhealthdata

ACTIONSTEPS•  Determiningtheprinciplesrespectingownership,security,access,sharing,leveragingandevencommercializinghealthdataneedstobedoneona‘holistic’basiswhereoldboundariesbetweenprivateandpublic,largeandsmalletcareerased

•  Canadahasthepotentialto‘win’inthedatamanagementandgovernancespaceandsetthestagefortheworld!

SuePaish

Artificial Intelligence & Machine Learning in Health Care SUMMARY•  Rapidgrowthanddevelopmentofpotentialapplicationsacrossoursystem•  Significantpotentialforsystemtransformationalopportunities-butneedalsotobeawareofprivacyandethicalissuesaswell.

NEXTSTEPS•  Industrykeentopartnerandcollaborate•  Ciscoannounced$10minvestmentinCapacitybuildinginwesternCanada•  Sightlines-launchinganewsecuredatatrustplatformthisweek•  Splunk-keentocollaboratewithCanadianHealthcareonrangeofinitiatives

HowardWaldner

Virtual Health: From Good Practices to Adoption

•  SUMMARY•  Virtualhealthhasdemonstrateditsvalueforpatientcentredcare.Whatdoweneedtodonowtoincreaseadoptionandscaleupofvirtualhealth?

• CONSIDERATIONStowardsACTIONSTEPS

•  Movetowardsanonlinehealthrecordsforpatients’access?•  Leveragetechnologiestostrengthenrelationships:healthprofessionals&patients,interprofessionalteammembers

•  Tailorvirtualhealthapproachesandcontenttooptimizeengagementandinvolvementofusersattheircomfortlevelintechnologyuse

•  Encouragesustainabilityofproventechnologies,andinnovationsofnewtechnologiestomeethealthgapsorprovideunprecedentedcarepathways

•  Ensureappropriateandhighqualityvirtualcaremodelstomaximizevalueandcosteffectiveness

KendallHo

Post-Secondary Healthcare Training Educational Requirements for Genomic Medicine in 2020 •  SUMMARY

•  Canadashoulddevelopaneducational“omics”platformthatwillenablemultiplecurriculaforpostsecondaryhealthcareprofessionals,andpatients.

• ACTIONSTEPS• Writeanopinionpiecethatincludestheimportantstepsrequired

•  WorkwitheducationalandindustrypartnersacrossCanada•  UseresourcesthatalreadyexistinothercountriessuchasNIH•  Enablecustomizationofcontenttogroupsofusersincludingpatients•  Enablenewknowledgetoinformtheeducationalprograms•  Explorewheretostartsuchaspharmacogenetics•  Lookatclinicalutilityincludingbioinformatics•  Considerdifferenteducationalstrategiessuchasthoseemployedbyindustry

MartinDawes

Personalized Medicine Through Innovation •  SUMMARY

•  BCisavibranthubforprecisionmedicinesandanascenthubforcompaniesfocusedonmolecularlybasedpreventivemedicine.

• ACTIONSTEPS•  Needtopublicizeoureffortsprovincially,nationallyandinternationally•  Conferencessuchasthisone..,lobbyforpreferentialtreatmentbyprovincialgovernment,federalgovernment…,attractPharmaandbigbiotech….

• Worktoattractventurecapitaltoscaletheseenterprises•  Focusacademiaandfundingbodiestosupporttheseindustriesofthefuture

PieterCullis

How to Deliver Personalized Medicine Today! •  SUMMARY

•  Makethedataaccessibleandeasytouseandputitinthecontrolofthepatient

• ACTIONSTEPS•  StartwithPharmacogenomicsandCancertherapies•  Provideeasytousetoolsforpractitionersandpatients•  Partnerwithcorporationsandinsurancegroups

RobFraser

Decentralizing and Democratizing Genomics with Blockchain

•  SUMMARY•  Blockchainhasthepotentialtohelpusaddresschallengesingenomicdatamanagement(datasilos,dataprivacy,dataownership,datasecurity)

•  Facilitatepatientdrivensystemsorinitiatives•  Activeanddynamicpatientconsent–patientcontroltheirdata•  Potentialbarriers:regulatory,education,userinterface

•  ACTIONSTEPS

•  NeedtocreatecapacityandexpertiseinblockchaininBC•  Advanceacademicprogramsandtrainingsinthefieldofgenomics,blockchain,AIandmachinelearning

•  AttractinternationalcompaniestostartdevelopingbusinessinBC•  Identifyopportunitiesforpatient,cliniciansresearchersinteractionssupportedbyblockchain(BCthePharmacogenomicsprovince!)

CatalinaLopez-Correa

Where do we go now? Ø Stoptakingmyblood!Ø Weneedastrategy!Ø Weneedtocollaborate!==================================================

•  PHSAmandatetobuildonthegenomicsandgeneticstestingframework•  Relationships,collaborations,engagement•  Strengthenconnections:clinical-research-academia

•  Pathwaytoclinicaluse•  Workwithstakeholderstodevelopa“ProvincialClinicalGenomicsTestingStrategy”•  UndertakeaninventoryofcurrentstateofclinicalgenomicstestinginBC•  Developevaluationcriteriafornewandexpandeduseofclinicalgenomicstesting

•  Datadriven,evidencebased,outcomesfocus•  Clinicalvalue,clinicalutility,actionable(ClinicalValueProposition)

•  Businesscase•  Operationalcostsandimpacts•  SystemROI

JimSlater

Panel Session Moderator Genetic Testing in the 21st Century Carolyn Bell

The Modern Patient Annemarie Kaan

Personalized Medicine & Oncology David Huntsman

Data Analytics: An Exciting Frontier Sue Paish

Artificial Intelligence & Machine Learning Howard Waldner

Virtual Health Kendall Ho

Post-Secondary Healthcare Training Martin Dawes

Personalized Medicine Through Innovation Pieter Cullis

How to Deliver Personalized Medicine Today Robert Fraser

Blockchain in Genomics Catalina Lopez-Correa

Where Do We Go Now? Jim Slater