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BME 484/485 Biomedical Engineering Capstone Design I & II 2014-2015
Credits and Contact Hours: 4 Credits (over 2 semesters, 2 credits for each semester)Fall semester schedule: Friday 1-6 pm (with a lecture 2-3 pm; Kelley Hall room 216
Instructor’s Name: Section 1: Prof. Ying Sun, [email protected], 401-874-2515Section 2: Dr. Eugene Chabot, <[email protected]>BME Technician: Tanya Wang <[email protected]>
Textbook: None. Using materials from previous courses (particularly BME 361 Biomeasurement laboratory), documentations on relevant projects, data sheets, relevant journal and conference papers, and Internet resources.
Course Information: Applications of engineering skills; team projects in biomedical areas such asneuroengineering, assistive technology, cardiopulmonary measurements, medical imaging, andmodeling of physiological systems. Two-course sequence. Prerequisites: BME 207 and BME 360.
Generalized and ABET Student OutcomesGeneralized Student Outcomes• To Understand – Describe the design process, performance specifications, functional
requirements and constraints. Define the design problem.• To Question – Evaluate design alternatives.• To Design - Design software and hardware to meet performance specifications, functional
requirements, and constraints.ABET Student Outcomes and Data to be AnalyzedC: Constraints such as economic, environmental, social, political, ethical, health and safety,
manufacturability, and sustainability. Data analysis: design with realistic constraints from the ABET outcome essay.
D: Ability to function on multi-disciplinary teams. Data analysis: multi-disciplinary teamwork from the ABET outcome essay.
J: Knowledge of contemporary issues. Data analysis: relevance to contemporary issues from the ABET outcome essay.
L: Ability to think critically about design alternatives and tradeoffs. Data analysis: design alternatives and tradeoffs from the ABET outcome essay.
Course Assessment Methods1. Project management & design process – 10%2. Mid-year progress report – 20%3. Project prototype – 30%4. Conference paper, grant proposal, & IRB application (if applicable) – 20%5. Final Report and documentation - 20%
Topics CoveredProject Management: • Design Process• Defining the Customer’s Design Problem• Performance Specifications, Functional Requirements• Evaluating Design Alternatives• Design Implementation and Project Timeline• FDA Guidelines, the Design History File• IRB approval for human study• Engineering Ethics and Obligations• Innovation, patent application, entrepreneurship • Presentations professional conferences
BME 484/485 Capstone Design Recommended Projects 2014-2015
1. Transcranial-magnetic Stimulation (TMS) HelmetDr. Brian Silver of RI Hospital wants to build a portable helmet with permanent magnets for rehabilitation of stroke patients. The magnets need to be flipped every, say, 30 minutes, which could be done manually. A meeting with Dr. Silver will take place at Rhode Island Hospital, Providence, om Monday (9/8), 3-4 pm.
2. Heart Rate Monitoring During Physical ExerciseThis is the IEEE Signal Processing Society Challenge: Using Wrist-Type Photoplethysmographic (PPG) Signals to monitor heart rate <http://icassp2015.org/signal-processing-cup-2015/>.
3. Multi-Sensory System For Monitoring Diskinesias in Movement Disorders (Dr. Kunal Mankodiya) This project sims at designing a body-worn multisensory system to detect dynamic symptoms––tremors, dyskinesias, and freezing of gait––associated with movement disorders . The sensors will send the data wirelessly to a close-by computer for signal processing and data analysis. It is also desired to produce symptom severity score which is very important element of clinical interventions. (already taken by Trevor Bernier, Dan Tamayo, Thomas Lennon)
4. SenseO2: Wearable Sensor for Muscle Oxygen Monitoring(Dr. Kunal Mankodiya) This project aims at building optoelectronics to conduct muscle spectroscopy for the measurement of tissue oxygenation. The optoelectronics circuits are made of LEDs and their drivers, photo detectors, trasnimpadence amplifier, bandpass filter, ADC and a micro controller. Students will gain expertise in building state-of-the-art wearable technology benefitting populations with diabetes or other metabolic disorders. For more info, watch the following video: <https://www.youtube.com/watch?v=Du_3Pfxdmx8&list=UUhKe7KXBkFcsgBbBqsJpDBA>.
5. An Electronic Model and Parameter Estimation for Cell Capacitance Exocytosis and endocytosis are important mechanisms for a cell to transport substances in and out.
This is typically done by forming vesicles that carry substances through the cell membrane. When a vesicle cross the cell membrane, the surface area of the cell momentarily increase, which can be observed by monitoring cell capacitance with an electrode. This capacitance change is very small (on the order of 10 femto farads) and very difficult to measure. Dr. Sun has a novel instrument and algorithm to monitor the cell capacitance in a fast and accurate fashion. This project involves the development of a novel analog cell capacitance model, Matlab programming, and/or PIC based instrumentation.
6. Testing of the Universal Clamp with the Neuron EmulatorUniversal Clamp is an innovative neuroscience instrument that has been developed at URI in collaboration with Neuroscience Tools, a St. Louis based company. This instrument uses a state-of-the-art digital signal processor (Analog Device Blackfin BF548) to interact with neurons. A prototype of the Universal Clamp has just been developed. This project involves the testing of the Universal Clamp for current clamping and voltage clamping on a previously developed neuron emulator.
7. EEG Front-end Design for Tripolar Electrodes using Driven Ground(Dr. Eugene Chabot)
8. Balance Board Rehabilitation Device Used for Improved Ankle Proprioception(Dr. Eugene Chabot)
9. Android Based Visual Sensory Substitution Device (Dr. Eugene Chabot) This device relays motion information through touch/auditory sense.
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10. EEG Based SwitchThe project is aimed at using the electroencephalogram (EEG) to operate a switch, which in turn can control assistive technology devices for persons with disabilities. Initially, a Brainwave Headset (NeuroSky Mindwave) will be used.
11. Implementation of AAGILE Using an Android SmartphoneActivity Analyzer with voice-Guidance for Independent Living Environments (AGGILE) is an invention of Prof. Patricia Burbank (URI Nursing) and Prof. Ying Sun. It is a wearable device of with motion sensors and voice record/playback IC to encourage exercise for the older adults. A previous prototype has been built on a PIC processor platform. This project will develop a new prototype of AAGILE based on an Android smartphone.
12. Voice Activated Environmental Control System Using an Android SmartphoneThis is a continuing project aiming at the development of a voice-activated smartphone-based system for controlling the environment via an X10 remote control for persons with disabilities.
13. Wrist Pulse SimulatorThis project is in collaboration with Dr. Mona Boudreaux and Prof. Faye Boudreaux-Bartels. Pulse diagnosis is an important technical for diagnosing various diseases in the traditional Chinese medicine (TCM). Using three fingers to feel the pulses at the wrist, an expert in TCM can detect up to 29 different pulse patterns. This project is aimed at developing a wrist pulse simulator to teach pulse diagnostic techniques.
14. Silicone Head model with Airway BlockagesThis project is aimed at developing a silicone head model with an anatomically correct airway. The focus of this project is to measure the frequency spectra of the breathing (airflow) sounds in relation to blockages at different sites such as the larynx and the back of the tongue where the problem of sleep apnea usually arises.
15. Pressure-Controlled Interface for a StethoscopeAlthough the stethoscope is ubiquitous tool for diagnosis, it has mainly been used as a qualitative tool, not a quantitative one. If you want to use quantitative data such as the frequency spectrum of sounds recorded with a stethoscope, the probe-skin interface could play an important role. The project is aimed at controlling the applied pressure and the pressure inside the stethoscope acoustic chamber such that the recorded frequency spectra can be optimized.
16. EMG Based Controls with Lego MindstormElectromyogram (EMG) can be used to control assistive technology devices. This is an continuing project that develops a PIC based 2-channel EMG systems to interface with a Lego Mindstorm system via a bluetooth link.
