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Gene Chasing with the Hierarchical Clustering Explorer:
Finding Meaningful Clusters in High Dimensional Data
Jinwook Seo and Ben Shneiderman
HCIL
Understanding Clusters
• Cluster Identification – How to identify interesting clusters– Interactive exploration of clustering results
• Understanding Clusters– Expert’s domain knowledge– Intuitive search mechanisms– Overlap of clusters and search results
Time 0 12Hr 1Day 2Day ……………………………. 30Day 40Day
Measure the activities of
12,422 genes
at 27 time points
Mouse Muscle Regeneration
Hierarchical Clustering Explorer• 1400 downloads since April 2002
– www.cs.umd.edu/hcil/hce– 1 commercial license to a biotech company
• Demonstration at HCIL1• Try HCE to analyze your multidimensional data
– 3138 US Counties– Demographic data
Sponsored by Children’s National Medical Center