7/29/2019 Gel Muscular
1/1
KlucelHXF 0.60
134 - Cj. 101, 10FloorhSouth Asia
TO-GEKCMethylSalicylate,15%andMenthol,7%HydroalcoholicClearGelThisgelfeaturesCarbopol*971PNFpolymerwhichimpartsviscosityandclaritytotheformulation.
IngredientName %w/wA 1. MethylSalicylate,USP 15.00
2. Menthol,USP 7.003. Carbopol971PNFPolymer 0.304. Ethanol
15.05. PropyleneGlycol 20.0
B 6. HydroxypropylCellulose7. Ethanol 20.08. PurifiedWater
21.50
C 9. 2-Amino-2-methyl-1propanol(20%solution) 0.4010.
LavenderFragrance 0.20
ProductPropertiesAppearance CleargelpH 6.5Viscosity(cP)**
8,900**BrookfieldRVT@20rpm,Spindle#5,measuredat24hoursStability-
Stableforaminimumof3monthswhenstoredunder
thefollowingICHconditions: Longterm(252C/605%relative humidity)
Accelerated(402C/755%relativehumidity)
KlucelisaregisteredtrademarkofAshland,Inc.Procedure1.
Dissolvementholinthemethylsalicylate.
AddinCarbopol971PNFpolymeranddisperse.
Addethanolandpropylene glycolandmixwell.
Keepthesolutioncoveredduringmixingtopreventsolventevaporation
(PartA).
2. Dispersethehydroxypropyl celluloseinethanolusingahomogenizer.
Addthepurifiedwaterandhomogenizetoobtainaclear,viscoussolution(PartB).
3.Add
Part
B
ingredients
to
Part
A
ingredients
and
mix
thoroughly.
4. Slowlyaddthe20%2-amino-2-methyl-1-propanol
solutionwhilemixing. Addfragranceandmixto
obtainaclear,viscousgel(PartC).
Edition: June1,201PreviousEdition: December19,200
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