Gds K-2Fis Intra-ekstra Uterine

7/24/2019 Gds K-2Fis Intra-ekstra Uterine

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PERUBAHAN LINGKUNGANINTRA EKSTRA UTERUS

TERHADAP FISIOLOGI

SISTEM TUBUH

Department of Physiology, Faculty of MedicineDepartment of Physiology, Faculty of MedicineUniversity of Sumatera Utara, MedanUniversity of Sumatera Utara, Medan

IndonesiaIndonesia


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PROSES E!"#IR"$

%Peru&ahan !in'( Intrauterine !in'( E'strauterine)

*at term+

*at term+O$R"SI uterus

%Fre'uensi-Durasi-Intensitas)

O$R"SI uterus

%Fre'uensi-Durasi-Intensitas)

Sir'ulasi %PO./P0O.) tergangguSir'ulasi%PO./P0O.) terganggu

"sphy1ia %PO. 2 P0O.

)

#eart Rate 3

4561/mnt 476-4861/mnt

&ila O. 466-4.61/mnt

"sphy1ia %PO. 2 P0O.

)

#eart Rate 3

4561/mnt 476-4861/mnt

&ila O. 466-4.61/mnt


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Peru&ahan SIRU!"SI segera setelah !ahir

Rangs( Dingin pd ulit 9 "sphy1ia

Rangs( Dingin pd ulit 9 "sphy1ia

:ayi lahir %normal)

:ayi lahir %normal)

:ayi Menangis

:ayi Menangis

PO. ;6-86 mm#g

Saturasi #&-O.3 86-


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at &irth

potong Um&ilical cord %tali pusat)

ahanan peripher

D( "orta >> D( "rt(Pulmonal

Sir'ulasi Plasenta %-)

"sphy1ia %0O.2 O. )

Menangis

ari' $apas

Paru mengem&ang

ahanan paru

D("orta D( pulmonal

Rangs( Dingin


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D( "orta >> D( "rt(Pulmonal

"liran darah paru

"liran "trium iri

2 "liran "trium anan

e'( "trium iri >>e'( "trium anan

Foramen Ovale ertutup


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:&rp( ?am postpartum:&rp( ?am postpartum

"liran "trium iri 2 "liran "trium anan

"liran darah "orta "rteri Pulmonalis

onstri'si Du'tus "rteriosus%Penutupan Fungsional)

4 - 5 :ulan

Fi&rosis Occluded

Sir'ulasi De@asa


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Circulati! i! F"tu# a!$ N"%&r!


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'

PERU:"#"$ SIRU!"SI

P!"SE$"

?"RI$A"$ U:U#

BE$ i "R i

P"RU

BE$ a "R a

FEUS PERI$""! %6-4 :ln) :"CI %4-5 :ln) De@asa

FO 3 Foramen Ovale

FO

D"

D" 3 Ductus "rteriosus

?"RI$A"$ U:U#

BE$ i "R i

P"RU

BE$ a "R a

D"

P!"SE$"

FO

P!"SE$"

P"RU

?"RI$A"$ U:U#

FO

BE$ i "R i

BE$ a "R a

P"RU

?"RI$A"$ U:U#

D"D"


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ME$"RI $"F"S PER"M" %he First :reath)

Peru&ahan Respirasi Placenta Respirasi paru

:ayi !ahir:ayi !ahir

Rangsang sensori' 3 ulit 2 OtotRangsang sensori' 3 ulit 2 Otot "sidosis Ringan"sidosis Ringan

Pusat PernapasanPusat Pernapasan

ontra'si otot-otot Pernapasanontra'si otot-otot Pernapasan

Bol( Intra hora's 2 e'( Intra hora'sBol( Intra hora's 2 e'( Intra hora's

Udara Masu' 'e ParuUdara Masu' 'e Paru


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REAU!"SI SU#U U:U#REAU!"SI SU#U U:U#

:ayi:ayi I'lim intrauterine %*tropis+)I'lim intrauterine %*tropis+)

I'lim E'strauterineI'lim E'strauterine

SRESSSRESS

Regulasi SuhuRegulasi Suhu

:E!UM S":I!:E!UM S":I!

Suhu u&uhSuhu u&uh

D S":I!D S":I!


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Regulasi Suhu :lm( Sta&il

hermogenesis %#eat Aain) hermolysis %#eat !oss)

a' dpt menggigil %respon

dingin) Sistem syaraf &lm(

Sempurna(

Respon dingin 3

Meta&olisme *&ro@n fat+

rigliserida

Free fatty acid

!uas permu'aan &ayi >>

De@asa

ulit 2 ?ar( Su&cutantipis #igh

0onductance Panas

hilang >>

0airan u&uh

:: %-46=) .- #r

pertama


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1313

FU$ASI !IBER

:ayi &aru lahir Sum&er Energi

A!IOAE$

!IBER, OO, ?"$U$A, dll

A!IOAE$

!IBER, OO, ?"$U$A, dll

:e&erapa am

postpartumA!IOAE$A!IOAE$


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REAU!"SI A!UOS"

Segera setelah lahir AD 6-56mg/466m!

:&rp( am

Ali'ogen

AD G.6mg/466m!

A!UO$EOAE$ESIS

Aangguan/gagal

Agn( Syaraf 2 oma

"pnoe 9 0yanosis

Pem&erianAlu'osa


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ME":O!ISME PROEI$ 2 !EM"

Fetus

Mela@ati *:arrier Placenta+

- Immunoglo&ulin

Mela@ati *:arrier Placenta+

- Immunoglo&ulin

a' Mela@ati *:arrier Placenta+

- Plasma Protein

- !ema'

a' Mela@ati *:arrier Placenta+

- Plasma Protein

- !ema'

Sintesa di #ati 3

"l&umin 2 !ema'

Sintesa di #ati 3

"l&umin 2 !ema'

"'tivasi Met( "s($u'leat 2

sintesa Protein

"'tivasi Met( "s($u'leat 2

sintesa ProteinSegera Setelah

!ahir


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:I!IRU:I$ 2 FU$ASI DEOHIFI"SI

Fungsi E's'resi :iliru&in %#ati) 2

Deto1ifi'asi O&at-o&atan

Fungsi E's'resi :iliru&in %#ati) 2Deto1ifi'asi O&at-o&atan

Physiological?oundice %-;

#ari)

Physiological?oundice %-;

#ari)

:lm( Sempurna:lm( Sempurna


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R"0( A"SROI$ESI$"!IS

*Rute P!"0E$"+ *Rute I$ESI$"!+

Aastric Emptying ime 3 -5 amAastric Emptying ime 3 -5 am

Enym !am&ung 2 #0l, p# 3 G

%pencernaan Susu)

Enym Intestinal, dan Empedu

0UUP

"milase Pan'reas GGG

Enym !am&ung 2 #0l, p# 3 G

%pencernaan Susu)

Enym Intestinal, dan Empedu

0UUP

"milase Pan'reas GGG

MOI!I"

S

MOI!I"

S

SERES

I

SERES

I

":SORPSI":SORPSIJat $utrisi :"I

ecuali !EM"

Jat $utrisi :"I

ecuali !EM"


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PE$A"UR"$

E$DORI$PERUM:U#"$

Foetus Aro@thFoetus Aro@th dipengaruhidipengaruhi 33

**Maternal $ourishment+Maternal $ourishment+

Estrogen 2 ProgesteronEstrogen 2 Progesteron

Fetus Aro@thFetus Aro@th Tdk.dipengaruhiTdk.dipengaruhi

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Aro@th #ormon FoetusAro@th #ormon Foetus

hyro1ine Foetushyro1ine Foetus


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1'

hyroid Aland

I:U

%#CPO#CROIDISM)

!ahir :ayi

%#CPO#CROIDISM)

PEREM:"$A"$"IF segera Stlh !ahir

%respon thd dingin)


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()()

"drenal orte's

orti'osteroid %9)

Respon 'elenar %9)

Pada urinePada urine

eadaan stresseadaan stress

"drenal

Medula

Saat !ahirSaat !ahir

Mempertahan'an

Sir'ulasi Darah Ota'

PO.PO.

"SP#CHI""SP#CHI"

Epinephrin/$EEpinephrin/$E

B"SOO$SRISIB"SOO$SRISI

Respon Meta&oli'

hd DI$AI$


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SISEM SC"R"F

Sist( Syaraf Pusat

Pertum&uhan 3

- mepd rimester II 2 III

%ma's)

*:erat 3 K &erat Ota' De@asa

Sifat Refle's

Fle1ion Refle1,menangis @'t(

!apar, memutar epala, dll(

:u'a mata %respon 0ahaya 2

Suara)

idur &ar&agai posisi


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PERAN HORMON DALAM

PROSES TUMBUH DAN

KEMBANG


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Multiple hormones, including growth hormone (GH),

insulin-like growth factors (IGF-I and -II), insulin, throid

hormones, glucocorticoids, androgens, and estrogenscontri!ute to the growth process in humans"

#mong these, GH and IGF-I ha$e !een implicated as the

ma%or determinants of growth in normal postuterine life"

Howe$er, deficiencies (or e&cesses) of each of the other

hormones can seriousl affect the normal growth of the

musculoskeletal sstem as well as the growth and

maturation of other tissues"


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Pancreas: Insulin

' actions hpoglcemic (lowers !lood

glucose)increases transport of glucose into muscle and fat

cells (*+ does not increase uptake ! !rain,

li$er, or kidne)

inhi!its !reakdown of glcogen and formation of

glucose from amino acids or fatt acids (inhi!its

glcogenolsis and gluconeogenesis)

promotes formation of glcogen (li$er, skeletal

muscles), protein snthesis (muscle), and fat

snthesis and storage (adipose)


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5. Pancreas: Insulin (Control)

' stimulated by:

increased blood glucose increased blood amino acid and

fatty acid levels

parasympathetic impulses

hyperglycemichormones (GHglucagon epinephrine

thyro!ine glucocorticoids)

indirectlyresult in insulin

secretion by increasing blood

glucose levels' inhibited by:

lo" blood glucose and by

somatostatin

sympathetic impulses


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Documents

Gds K-2Fis Intra-ekstra Uterine