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REFERENCE CODE GDHCER038 | PUBLICAT ION DATE SEPTEMBER 2013
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Uveitis - Epidemiology Forecast to 2022 2 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
Executive Summary
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Uveitis is a serious eye condition that often results
in permanent vision damage due to frequent
recurrence even after treatment. It consists of a
group of diseases that present with inflammation of
the uvea, can occur in one or both eyes, and may
also affect the adjacent tissues such as the retina,
optic nerve, and vitreous humor. The global annual
incidence of uveitis is between 17 cases per
100,000 population in Switzerland and 52 cases
per 100,000 population in the US, whereas the
prevalence is between 38 cases per 100,000
population in France and 714 cases per 100,000
population in India (Miserocchi et al., 2013).
This report provides an overview of the risk factors,
comorbidities and the global epidemiological trends
for uveitis in the six major markets (6MM: US,
France, Germany, Italy, Spain, and UK). The report
also includes a 10-year forecast of incident and
prevalent cases of uveitis segmented by age, sex,
primary anatomical location of inflammation
(anterior, intermediate, posterior, panuveitis), and
by etiology (infectious, non-infectious, idiopathic).
Incident cases are further segmented by course of
disease (acute, recurrent, chronic) and by severity
(mild, moderate, severe).
The figures below present forecast incident and
prevalent cases of uveitis in the 6MM.In 2012, the
6MM had 223,559 incident cases of uveitis, 75% of
which (168,264 cases) occurred in the US. Incident
cases in the 6MM are expected to increase slightly
to 245,353 cases by 2022, at the rate of 0.97% per
year. In 2012, the 6MM had 665,778 prevalent
cases of uveitis, which will increase to 730,913
cases in 2022 at the rate of 0.98% per year. The
US also had the largest proportion of prevalent
cases in 2012 (53.69%, 357,483 cases) out of all
markets covered in this analysis. The forecast
further shows anterior uveitis is the most common
form of uveitis and non-infectious uveitis is the
most common etiology among the 6MM.
This forecast provides detailed, granular, and
clinically relevant segmentations of uveitis cases.
The segmentations will allow for improved
understanding of the disease and the ability to
focus on specific subgroups within the disease.
The analysis is further strengthened by the
adherence to the standard clinical reporting
guidelines from the International Uveitis Study
Group (IUSG) and Standardization of Uveitis
Nomenclature (SUN) Working Group. Using
standard guidelines across the 6MM allows for
meaningful comparisons across the markets and
ensures these results will be relevant in reference
to future studies, as the use of the guidelines are
becoming more common in epidemiological
research.
Uveitis - Epidemiology Forecast to 2022 3 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Executive Summary
6MM, Incident Cases of Uveitis, N, 2012 and 2022
8,941
8,482
11,364
11,842
14,666
55,295
168,264
223,559
9,123
9,128
11,962
12,320
14,400
56,933
188,420
245,353
0 50,000 100,000 150,000 200,000 250,000
Italy
Spain
UK
France
Germany
5EU
US
6MM
Incident Cases of Uveitis (N)
Mar
kets
2022
2012
Source: GlobalData; Barisani-Asenbauer et al., 2012; Cimino et al., 2010; Gritz and Wong, 2004; Jakob et al., 2009; Mercanti et al., 2001; Päivönsalo-Hietanen et al., 1997; Pivetti-Pezzi et al., 1996; Smit et al., 1993; Tran et al., 1995; USCB, 2012. Note: 5EU = France, Germany, Italy, Spain, and UK; 6MM = 5EU, US.
6MM, Prevalent Cases of Uveitis, N, 2012 and 2022
44,819
57,888
60,613
61,805
83,170
308,295
357,483
665,778
50,710
62,459
65,351
65,916
84,455
328,891
402,022
730,913
0 200,000 400,000 600,000
Spain
UK
France
Italy
Germany
5EU
US
6MM
Prevalent Cases of Uveitis (N)
Mar
kets
2022
2012
Source: GlobalData; Cooper et al., 2009; Eaton et al., 2007; Gritz and Wong, 2004; Päivönsalo-Hietanen et al., 1997; USCB, 2012; Vadot et al., 1984. 5EU = France, Germany, Italy, Spain, and UK; 6MM = 5EU, US.
Uveitis - Epidemiology Forecast to 2022 4 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Table of Contents
1 Table of Contents
1 Table of Contents .......................................................................................................................... 4
1.1 List of Tables............................................................................................................................ 7
1.2 List of Figures .......................................................................................................................... 8
2 Introduction ................................................................................................................................... 9
2.1 Catalyst .................................................................................................................................... 9
2.2 Related Reports ..................................................................................................................... 10
2.3 Upcoming Reports ................................................................................................................. 10
3 Epidemiology ............................................................................................................................... 11
3.1 Disease Background .............................................................................................................. 11
3.2 Risk Factors and Comorbidities.............................................................................................. 12
3.2.1 Smoking increases risk of uveitis and increases complications ....................................... 12
3.2.2 Juvenile idiopathic arthritis patients need regular ophthalmologic screenings ................. 13
3.2.3 HLA-positive antigens are linked to certain types of uveitis ............................................. 14
3.2.4 Uveitis is associated with various autoimmune, neurological, and infectious diseases .... 14
3.3 Global Trends ........................................................................................................................ 16
3.3.1 US .................................................................................................................................. 18
3.3.2 5EU ................................................................................................................................ 21
3.4 Forecast Methodology ............................................................................................................ 23
3.4.1 Sources Used ................................................................................................................. 26
3.4.2 Sources Not Used........................................................................................................... 31
3.4.3 Forecast Assumptions and Methods, Incident Cases ...................................................... 32
3.4.4 Forecast Assumptions and Methods, Prevalent Cases ................................................... 33
Uveitis - Epidemiology Forecast to 2022 5 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Table of Contents
3.4.5 Forecast Assumptions and Methods, Etiological and Anatomical Distribution ................. 34
3.4.6 Forecast Assumptions and Methods, Course of Disease ................................................ 37
3.4.7 Forecast Assumptions and Methods, Disease Severity .................................................. 38
3.5 Epidemiological Forecast of Uveitis (2012–2022) ................................................................... 38
3.5.1 Incident Cases of Uveitis ................................................................................................ 38
3.5.2 Age-Specific Incident Cases of Uveitis ............................................................................ 40
3.5.3 Sex-Specific Incident Cases ........................................................................................... 42
3.5.4 Age-Standardized Incidence Rates ................................................................................. 43
3.5.5 Incident Cases by Anatomical Location .......................................................................... 44
3.5.6 Incident Cases Segmented by Etiology ........................................................................... 46
3.5.7 Course of Disease of Incident Uveitis Cases .................................................................. 49
3.5.8 Severity of Incident Uveitis Cases ................................................................................... 51
3.5.9 Prevalent Cases of Uveitis .............................................................................................. 52
3.5.10 Age-Specific Prevalent Cases of Uveitis ......................................................................... 54
3.5.11 Sex-Specific Prevalent Cases of Uveitis ......................................................................... 55
3.5.12 Prevalent Cases by Anatomical Location ........................................................................ 57
3.5.13 Prevalent Cases by Etiology ........................................................................................... 58
3.6 Discussion ............................................................................................................................. 60
3.6.1 Epidemiological Forecast Insight .................................................................................... 60
3.6.2 Limitations of the Analysis .............................................................................................. 60
3.6.3 Strengths of the Analysis ................................................................................................ 62
4 Appendix ..................................................................................................................................... 63
4.1 Bibliography ........................................................................................................................... 63
Uveitis - Epidemiology Forecast to 2022 6 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Table of Contents
4.2 About the Authors .................................................................................................................. 68
4.2.1 Epidemiologists .............................................................................................................. 68
4.2.2 Reviewers ....................................................................................................................... 68
4.2.3 Global Director of Epidemiology and Health Policy ......................................................... 70
4.2.4 Global Head of Healthcare .............................................................................................. 70
4.3 About GlobalData ................................................................................................................... 71
4.4 About EpiCast ........................................................................................................................ 71
4.5 Disclaimer .............................................................................................................................. 72
Uveitis - Epidemiology Forecast to 2022 7 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Table of Contents
1.1 List of Tables
Table 1: Diseases Most Frequently Associated with Uveitis ....................................................................... 15
Table 2: Distribution of Uveitis by Anatomical Location in Community and Referral Centers ....................... 21
Table 3: Distribution of Uveitis Cases by Anatomical Location of Inflammation, Europe .............................. 23
Table 4: IUSG/SUN Working Group Classification of Uveitis by Anatomical Location ................................. 24
Table 5: Clinical Classifications of Uveitis .................................................................................................. 24
Table 6: 6MM, Sources of Incidence and Prevalence of Uveitis in the 6MM ............................................... 25
Table 7: Italy, Anatomy Classification Calculation ...................................................................................... 35
Table 8: US, Anatomical Locations of Uveitis for Incident and Prevalent Cases .......................................... 37
Table 9: 6MM, Incident Cases of Uveitis, N (Column %), Select Years 2012–2022..................................... 39
Table 10: 6MM, Age-Specific Incident Cases of Uveitis, N (Row %), 2012 ................................................... 40
Table 11: 6MM, Sex-Specific Incident Cases of Uveitis, N (Row %), 2012.................................................... 42
Table 12: 6MM, Incident Cases of Uveitis by Primary Anatomical Location of Inflammation, N (Row %),
2012 ............................................................................................................................................ 45
Table 13: 6MM, Incident Cases of Uveitis Segmented by Etiology and Age, N (Column %), 2012 ................ 47
Table 14: 6MM, Incident Cases of Uveitis Segmented by Etiology and Anatomical Location, N, 2012 .......... 48
Table 15: 6MM, Incident Cases of Uveitis by Course of Disease, N (Row %), 2012 ...................................... 49
Table 16: 6MM, Incident Cases of Uveitis by Severity of Disease, N, 2012 ................................................... 51
Table 17: 6MM, Prevalent Cases of Uveitis, N (Column %), Select Years, 2012–2022 ................................. 53
Table 18: 6MM, Age-Specific Prevalent Cases of Uveitis, N (Row %), 2012 ................................................. 54
Table 19: 6MM, Sex-Specific Prevalent Cases of Uveitis, N (Row %), 2012 ................................................. 56
Table 20: 6MM, Prevalent Cases of Uveitis by Anatomical Location of Inflammation, N (Row %), 2012 ........ 57
Table 21: 6MM, Prevalent Cases of Uveitis Segmented by Etiology and Age, N (Column %), 2012 .............. 58
Table 22: 6MM, Prevalent Cases of Uveitis Segmented by Etiology and Anatomical Location, 2012 ............ 59
Uveitis - Epidemiology Forecast to 2022 8 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Table of Contents
1.2 List of Figures
Figure 1: US, Age Distribution of Study Populations Compared with the US General Population ................. 19
Figure 2: US, Sex-Ratio of Study Populations Compared with the US General Population ........................... 20
Figure 3: 6MM, Incident Cases of Uveitis, N, 2012–2022 ............................................................................ 39
Figure 4: 6MM, Age-Specific Incident Cases of Uveitis, N, 2012 .................................................................. 41
Figure 5: 6MM, Sex-Specific Incident Cases of Uveitis, N, 2012 .................................................................. 43
Figure 6: 6MM, Age-Standardized Uveitis Incidence, Cases per 100,000 Population, Men and Women,
2012 ............................................................................................................................................ 44
Figure 7: 6MM, Incident Cases of Uveitis by Primary Anatomical Location of Inflammation, N, 2012 ............ 46
Figure 8: 6MM, Incident Cases of Uveitis by Course of Disease, N, 2012 .................................................... 50
Figure 9: 6MM, Incident Cases of Uveitis by Severity of Disease, N, 2012 ................................................... 52
Figure 10: 6MM, Prevalent Cases of Uveitis, N, 2012–2022 .......................................................................... 53
Figure 11: 6MM, Age-Specific Prevalent Cases of Uveitis, N, 2012 ............................................................... 55
Figure 12: 6MM, Sex-Specific Prevalent Cases of Uveitis, N, 2012 ............................................................... 56
Uveitis - Epidemiology Forecast to 2022 9 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Introduction
2 Introduction
2.1 Catalyst
Uveitis is a serious eye condition that often results in permanent vision damage due to frequent
recurrence even after treatment. The global annual incidence of uveitis is between 17 cases per
100,000 population in Switzerland and 52 cases per 100,000 population in the US, whereas the
prevalence is between 38 cases per 100,000 population in France and 714 cases per 100,000
population in India (Miserocchi et al., 2013). Uveitis epidemiology warrants thorough analysis, as
recent studies have found incidence and prevalence rates that are significantly higher than
previously believed, especially in the elderly population.
This report provides an overview of the risk factors, comorbidities, and the global
epidemiological trends for uveitis in the six major markets (6MM: US, France, Germany, Italy,
Spain, and UK). In addition, the report also includes a 10-year forecast of incident and
prevalent cases of uveitis segmented by age, sex, primary anatomical location of inflammation
(anterior, intermediate, posterior, panuveitis), and by etiology (infectious, non-infectious,
idiopathic). Incident cases are further segmented by course of disease (acute, recurrent,
chronic) and by severity (mild, moderate, severe).
GlobalData epidemiologists used standardized clinical guidelines from the International Uveitis
Study Group (IUSG) and the Standardization of Uveitis Nomenclature (SUN) Working Group to
construct the epidemiologic forecast.
GlobalData epidemiologists forecast that the 6MM had 223,559 incident and 665,778 prevalent
cases of uveitis in 2012. The US had significantly higher numbers of incident and prevalent
cases than the European markets.
The forecast shows that anterior uveitis is the most common form of uveitis, and non-infectious
uveitis is the most common etiology among the 6MM.
More population-based epidemiological studies are needed to elucidate the cause of observed
high incidence and prevalence rates. Studies of temporal trends of uveitis in different
populations are also urgently needed.
Uveitis - Epidemiology Forecast to 2022 10 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Introduction
2.2 Related Reports
GlobalData (2013). OpportunityAnalyzer – Uveitis
2.3 Upcoming Reports
GlobalData (2013). EpiCast Report: Breast Cancer Epidemiology Forecast to 2022
Uveitis - Epidemiology Forecast to 2022 71 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Appendix
4.3 About GlobalData
GlobalData is a leading global provider of business intelligence in the Healthcare industry.
GlobalData provides its clients with up-to-date information and analysis on the latest developments
in drug research, disease analysis, and clinical research and development. Our integrated business
intelligence solutions include a range of interactive online databases, analytical tools, reports and
forecasts. Our analysis is supported by a 24/7 client support and analyst team.
GlobalData has offices in New York, Boston, London, India and Singapore.
4.4 About EpiCast
EpiCast is a series of premier epidemiology reports written and developed by Masters
and PhD level epidemiologists.
EpiCast Reports are in-depth, high quality, transparent and market-driven, providing expert
analysis of epidemiological trends and forecasting of patient populations for major markets.
Specifically, the reports identify disease trends over a 10-year forecast period in six to seven major
markets (US, France, Germany, Italy, Spain, UK, Japan). Additional countries, such as Canada,
Brazil, India and China, are covered in these reports if their markets are highly relevant.
Uveitis - Epidemiology Forecast to 2022 72 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form.
UVEITIS - EPIDEMIOLOGY FORECAST TO 2022
Appendix
4.5 Disclaimer
All Rights Reserved.
No part of this publication may be reproduced, stored in a retrieval system or transmitted in any
form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior
permission of the publisher, GlobalData.